2LDX

characterization of the antigenic sites on the refined 3- angstroms resolution structure of mouse testicular lactate dehydrogenase c4

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 146
  • Norm. En. per Res.: -1.6819
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-26.2953	10.1592	180.515	164.3788	116	174	21	16806	0	10	21
A-C	-57.1704	-41.9599	-313.847	-412.9773	248	103	22	25741	6	52	48
A-D	-113.661	28.0786	-159.977	-245.5594	146	134	8	14945	0	50	53
B-C	-102.5317	28.0786	-167.864	-242.3171	146	132	8	14942	0	50	53
B-D	-57.1704	-41.9599	-313.847	-412.9773	248	103	22	25741	6	52	48
C-D	-26.2953	10.1592	180.515	164.3788	116	174	21	16806	0	10	21

Interface residues

• A-B: ALA206A, ALA206B, ALA216A, ALA216B, ARG170A, ARG170B, ARG260A, ARG260B, ARG268A, ARG268B, ASN180A, ASN180B, ASN204A, ASN204B, ASN214A, ASN214B, ASN265A, ASN265B, ASN306A, ASN306B, ASP301A, ASP301B, CYS184A, CYS184B, CYS292A, CYS292B, GLU175A, GLU175B, GLU311A, GLU311B, GLY174A, GLY174B, GLY178A, GLY178B, GLY186A, GLY186B, GLY202A, GLY202B, GLY207A, GLY207B, HIS185A, HIS185B, HIS270A, HIS270B, ILE199A, ILE199B, LEU177A, LEU177B, LEU189A, LEU189B, LEU210A, LEU210B, LEU213A, LEU213B, LEU266A, LEU266B, LEU294A, LEU294B, LYS211A, LYS211B, LYS267A, LYS267B, LYS304A, LYS304B, MET307A, MET307B, PHE169A, PHE169B, PHE302A, PHE302B, PRO181A, PRO181B, PRO215A, PRO215B, PRO271A, PRO271B, PRO291A, PRO291B, SER183A, SER183B, SER201A, SER201B, SER212A, SER212B, SER261A, SER261B, THR182A, THR182B, THR209A, THR209B, THR300A, THR300B, THR308A, THR308B, TRP187A, TRP187B, TRP200A, TRP200B, VAL179A, VAL179B, VAL188A, VAL188B, VAL203A, VAL203B, VAL205A, VAL205B, VAL208A, VAL208B, VAL269A, VAL269B, VAL293A, VAL293B, VAL303A, VAL303B, VAL305A, VAL305B
• A-C: ALA167A, ALA167C, ALA206A, ALA206C, ALA216A, ALA216C, ALA250A, ALA250C, ALA33A, ALA33C, ALA35A, ALA35C, ALA61A, ALA61C, ARG168A, ARG168C, ARG170A, ARG170C, ARG260A, ARG260C, ARG268A, ARG268C, ARG58A, ARG58C, ASN163A, ASN163C, ASN180A, ASN180C, ASN204A, ASN204C, ASN214A, ASN214C, ASP165A, ASP165C, ASP220A, ASP220C, ASP242A, ASP242C, ASP257A, ASP257C, ASP29A, ASP29C, ASP53A, ASP53C, ASP55A, ASP55C, ASP63A, ASP63C, CYS184A, CYS184C, CYS34A, CYS34C, GLN224A, GLN224C, GLN232A, GLN232C, GLN65A, GLN65C, GLN6A, GLN6C, GLN9A, GLN9C, GLU175A, GLU175C, GLU235A, GLU235C, GLU239A, GLU239C, GLU5A, GLU5C, GLU60A, GLU60C, GLY174A, GLY174C, GLY178A, GLY178C, GLY186A, GLY186C, GLY207A, GLY207C, GLY218A, GLY218C, GLY236A, GLY236C, GLY237A, GLY237C, GLY245A, GLY245C, GLY252A, GLY252C, GLY28A, GLY28C, GLY31A, GLY31C, GLY59A, GLY59C, GLY67A, GLY67C, HIS185A, HIS185C, HIS225A, HIS225C, HIS270A, HIS270C, HIS66A, HIS66C, ILE173A, ILE173C, ILE217A, ILE217C, ILE251A, ILE251C, ILE36A, ILE36C, ILE38A, ILE38C, ILE76A, ILE76C, ILE8A, ILE8C, LEU164A, LEU164C, LEU172A, LEU172C, LEU177A, LEU177C, LEU210A, LEU210C, LEU213A, LEU213C, LEU241A, LEU241C, LEU253A, LEU253C, LEU258A, LEU258C, LEU39A, LEU39C, LEU40A, LEU40C, LEU43A, LEU43C, LEU49A, LEU49C, LEU57A, LEU57C, LEU62A, LEU62C, LEU64A, LEU64C, LEU69A, LEU69C, LEU71A, LEU71C, LEU7A, LEU7C, LYS176A, LYS176C, LYS211A, LYS211C, LYS244A, LYS244C, LYS41A, LYS41C, LYS4A, LYS4C, LYS56A, LYS56C, LYS75A, LYS75C, MET243A, MET243C, MET32A, MET32C, PHE169A, PHE169C, PHE70A, PHE70C, PHE78A, PHE78C, PRO181A, PRO181C, PRO215A, PRO215C, PRO74A, PRO74C, SER166A, SER166C, SER183A, SER183C, SER1A, SER1C, SER212A, SER212C, SER248A, SER248C, SER254A, SER254C, SER37A, SER37C, SER68A, SER68C, SER72A, SER72C, THR182A, THR182C, THR219A, THR219C, THR247A, THR247C, THR256A, THR256C, THR2A, THR2C, THR54A, THR54C, THR73A, THR73C, TRP226A, TRP226C, TRP249A, TRP249C, TYR171A, TYR171C, TYR238A, TYR238C, TYR246A, TYR246C, VAL179A, VAL179C, VAL203A, VAL203C, VAL205A, VAL205C, VAL233A, VAL233C, VAL234A, VAL234C, VAL240A, VAL240C, VAL255A, VAL255C, VAL27A, VAL27C, VAL30A, VAL30C, VAL3A, VAL3C
• A-D: ALA44A, ALA44D, ARG156A, ARG156D, ARG19A, ARG19D, ARG260A, ARG260D, ARG268A, ARG268D, ASN10A, ASN10D, ASN265A, ASN265D, ASN306A, ASN306D, ASP15A, ASP15D, ASP301A, ASP301D, ASP45A, ASP45D, CYS20A, CYS20D, CYS292A, CYS292D, GLN6A, GLN6D, GLN9A, GLN9D, GLU14A, GLU14D, GLU296A, GLU296D, GLU46A, GLU46D, GLU5A, GLU5D, GLY155A, GLY155D, GLY278A, GLY278D, GLY295A, GLY295D, GLY298A, GLY298D, GLY42A, GLY42D, HIS280A, HIS280D, ILE158A, ILE158D, ILE262A, ILE262D, ILE290A, ILE290D, ILE299A, ILE299D, ILE8A, ILE8D, LEU11A, LEU11D, LEU17A, LEU17D, LEU263A, LEU263D, LEU266A, LEU266D, LEU275A, LEU275D, LEU294A, LEU294D, LEU43A, LEU43D, LEU71A, LEU71D, LEU7A, LEU7D, LYS131A, LYS131D, LYS16A, LYS16D, LYS264A, LYS264D, LYS267A, LYS267D, LYS277A, LYS277D, LYS304A, LYS304D, LYS41A, LYS41D, LYS4A, LYS4D, LYS75A, LYS75D, LYS89A, LYS89D, PHE279A, PHE279D, PHE287A, PHE287D, PHE302A, PHE302D, PHE70A, PHE70D, PRO13A, PRO13D, PRO153A, PRO153D, PRO291A, PRO291D, PRO74A, PRO74D, SER18A, SER18D, SER261A, SER261D, SER297A, SER297D, SER72A, SER72D, THR274A, THR274D, THR300A, THR300D, THR73A, THR73D, VAL12A, VAL12D, VAL154A, VAL154D, VAL208A, VAL208D, VAL269A, VAL269D, VAL276A, VAL276D, VAL293A, VAL293D, VAL303A, VAL303D, VAL305A, VAL305D, VAL3A, VAL3D
• B-C: ALA44B, ALA44C, ARG156B, ARG156C, ARG19B, ARG19C, ARG260B, ARG260C, ARG268B, ARG268C, ASN10B, ASN10C, ASN265B, ASN265C, ASN306B, ASN306C, ASP15B, ASP15C, ASP301B, ASP301C, ASP45B, ASP45C, CYS20B, CYS20C, CYS292B, CYS292C, GLN6B, GLN6C, GLN9B, GLN9C, GLU14B, GLU14C, GLU296B, GLU296C, GLU46B, GLU46C, GLU5B, GLU5C, GLY155B, GLY155C, GLY278B, GLY278C, GLY295B, GLY295C, GLY298B, GLY298C, GLY42B, GLY42C, HIS280B, HIS280C, ILE158B, ILE158C, ILE262B, ILE262C, ILE290B, ILE290C, ILE299B, ILE299C, ILE8B, ILE8C, LEU11B, LEU11C, LEU17B, LEU17C, LEU263B, LEU263C, LEU266B, LEU266C, LEU275B, LEU275C, LEU294B, LEU294C, LEU43B, LEU43C, LEU71B, LEU71C, LEU7B, LEU7C, LYS131B, LYS131C, LYS16B, LYS16C, LYS264B, LYS264C, LYS267B, LYS267C, LYS277B, LYS277C, LYS304B, LYS304C, LYS41B, LYS41C, LYS4B, LYS4C, LYS75B, LYS75C, LYS89B, LYS89C, PHE279B, PHE279C, PHE287B, PHE287C, PHE302B, PHE302C, PHE70B, PHE70C, PRO13B, PRO13C, PRO153B, PRO153C, PRO291B, PRO291C, PRO74B, PRO74C, SER18B, SER18C, SER261B, SER261C, SER297B, SER297C, SER72B, SER72C, THR274B, THR274C, THR300B, THR300C, THR73B, THR73C, VAL12B, VAL12C, VAL154B, VAL154C, VAL208B, VAL208C, VAL269B, VAL269C, VAL276B, VAL276C, VAL293B, VAL293C, VAL303B, VAL303C, VAL305B, VAL305C, VAL3B, VAL3C
• B-D: ALA167B, ALA167D, ALA206B, ALA206D, ALA216B, ALA216D, ALA250B, ALA250D, ALA33B, ALA33D, ALA35B, ALA35D, ALA61B, ALA61D, ARG168B, ARG168D, ARG170B, ARG170D, ARG260B, ARG260D, ARG268B, ARG268D, ARG58B, ARG58D, ASN163B, ASN163D, ASN180B, ASN180D, ASN204B, ASN204D, ASN214B, ASN214D, ASP165B, ASP165D, ASP220B, ASP220D, ASP242B, ASP242D, ASP257B, ASP257D, ASP29B, ASP29D, ASP53B, ASP53D, ASP55B, ASP55D, ASP63B, ASP63D, CYS184B, CYS184D, CYS34B, CYS34D, GLN224B, GLN224D, GLN232B, GLN232D, GLN65B, GLN65D, GLN6B, GLN6D, GLN9B, GLN9D, GLU175B, GLU175D, GLU235B, GLU235D, GLU239B, GLU239D, GLU5B, GLU5D, GLU60B, GLU60D, GLY174B, GLY174D, GLY178B, GLY178D, GLY186B, GLY186D, GLY207B, GLY207D, GLY218B, GLY218D, GLY236B, GLY236D, GLY237B, GLY237D, GLY245B, GLY245D, GLY252B, GLY252D, GLY28B, GLY28D, GLY31B, GLY31D, GLY59B, GLY59D, GLY67B, GLY67D, HIS185B, HIS185D, HIS225B, HIS225D, HIS270B, HIS270D, HIS66B, HIS66D, ILE173B, ILE173D, ILE217B, ILE217D, ILE251B, ILE251D, ILE36B, ILE36D, ILE38B, ILE38D, ILE76B, ILE76D, ILE8B, ILE8D, LEU164B, LEU164D, LEU172B, LEU172D, LEU177B, LEU177D, LEU210B, LEU210D, LEU213B, LEU213D, LEU241B, LEU241D, LEU253B, LEU253D, LEU258B, LEU258D, LEU39B, LEU39D, LEU40B, LEU40D, LEU43B, LEU43D, LEU49B, LEU49D, LEU57B, LEU57D, LEU62B, LEU62D, LEU64B, LEU64D, LEU69B, LEU69D, LEU71B, LEU71D, LEU7B, LEU7D, LYS176B, LYS176D, LYS211B, LYS211D, LYS244B, LYS244D, LYS41B, LYS41D, LYS4B, LYS4D, LYS56B, LYS56D, LYS75B, LYS75D, MET243B, MET243D, MET32B, MET32D, PHE169B, PHE169D, PHE70B, PHE70D, PHE78B, PHE78D, PRO181B, PRO181D, PRO215B, PRO215D, PRO74B, PRO74D, SER166B, SER166D, SER183B, SER183D, SER1B, SER1D, SER212B, SER212D, SER248B, SER248D, SER254B, SER254D, SER37B, SER37D, SER68B, SER68D, SER72B, SER72D, THR182B, THR182D, THR219B, THR219D, THR247B, THR247D, THR256B, THR256D, THR2B, THR2D, THR54B, THR54D, THR73B, THR73D, TRP226B, TRP226D, TRP249B, TRP249D, TYR171B, TYR171D, TYR238B, TYR238D, TYR246B, TYR246D, VAL179B, VAL179D, VAL203B, VAL203D, VAL205B, VAL205D, VAL233B, VAL233D, VAL234B, VAL234D, VAL240B, VAL240D, VAL255B, VAL255D, VAL27B, VAL27D, VAL30B, VAL30D, VAL3B, VAL3D
• C-D: ALA206C, ALA206D, ALA216C, ALA216D, ARG170C, ARG170D, ARG260C, ARG260D, ARG268C, ARG268D, ASN180C, ASN180D, ASN204C, ASN204D, ASN214C, ASN214D, ASN265C, ASN265D, ASN306C, ASN306D, ASP301C, ASP301D, CYS184C, CYS184D, CYS292C, CYS292D, GLU175C, GLU175D, GLU311C, GLU311D, GLY174C, GLY174D, GLY178C, GLY178D, GLY186C, GLY186D, GLY202C, GLY202D, GLY207C, GLY207D, HIS185C, HIS185D, HIS270C, HIS270D, ILE199C, ILE199D, LEU177C, LEU177D, LEU189C, LEU189D, LEU210C, LEU210D, LEU213C, LEU213D, LEU266C, LEU266D, LEU294C, LEU294D, LYS211C, LYS211D, LYS267C, LYS267D, LYS304C, LYS304D, MET307C, MET307D, PHE169C, PHE169D, PHE302C, PHE302D, PRO181C, PRO181D, PRO215C, PRO215D, PRO271C, PRO271D, PRO291C, PRO291D, SER183C, SER183D, SER201C, SER201D, SER212C, SER212D, SER261C, SER261D, THR182C, THR182D, THR209C, THR209D, THR300C, THR300D, THR308C, THR308D, TRP187C, TRP187D, TRP200C, TRP200D, VAL179C, VAL179D, VAL188C, VAL188D, VAL203C, VAL203D, VAL205C, VAL205D, VAL208C, VAL208D, VAL269C, VAL269D, VAL293C, VAL293D, VAL303C, VAL303D, VAL305C, VAL305D