2JKT

ap2 clathrin adaptor core with cd4 dileucine peptide rm( phosphos)eikrllse q to e mutant

• Total interactions analyzed: 45
• Total true interactions: 23
• Strongest Interaction:
  • Chains: E-L
  • Int. Res.: 145
  • Norm. En. per Res.: -4.6681
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-72.9508	-98.285	-411.809	-583.0448	140	31	5	17914	9	62	64
A-E	-5.8134	-26.1932	-68.9783	-100.9849	59	2	0	3260	2	34	10
A-L	0.0	25.4756	-102.333	-76.8574	86	10	0	4763	4	35	41
A-M	-31.7757	-31.1158	-350.62	-413.5116	167	31	9	15032	4	67	58
A-P	0.0	-15.5506	-0.8925	-16.4431	6	0	0	64	0	1	0
A-S	-48.1768	-65.1022	-607.233	-720.512	247	53	22	26251	6	64	66
A-U	0.0	12.175	-14.7756	-2.6006	24	4	0	637	0	5	13
B-L	-24.5199	-36.5049	-79.9311	-140.9559	58	6	1	3818	2	38	12
B-M	-83.7704	-181.2993	-793.206	-1058.2756	313	65	27	33897	16	128	81
B-P	0.0	0.0	-0.2348	-0.2348	6	0	0	47	0	2	2
B-U	0.0	2.5211	-57.2574	-54.7363	37	3	0	2961	0	5	6
E-L	-100.8662	-104.9534	-471.051	-676.8706	145	58	5	19570	9	64	67
E-M	0.0	2.5042	-49.0726	-46.5684	35	2	0	2674	0	5	5
E-Q	0.0	0.0	-0.4967	-0.4967	7	0	0	83	0	3	2
E-U	-70.7934	-175.0372	-773.092	-1018.9226	309	51	27	33276	17	128	81
I-L	-63.3958	-62.9361	-617.273	-743.6049	247	44	21	26347	6	62	65
I-Q	-7.9738	6.3236	-153.667	-155.3171	47	11	8	6169	2	10	10
I-U	-8.9006	-11.6509	-129.684	-150.2355	62	6	1	5309	0	22	24
L-M	0.0	14.034	-12.333	1.701	25	2	0	587	0	5	13
L-Q	0.0	-18.081	-1.4747	-19.5557	6	0	0	77	1	1	0
L-U	-35.9779	-23.9442	-328.039	-387.9611	164	19	10	14686	2	67	56
M-S	-4.5291	-11.9342	-145.475	-161.9383	64	13	2	5791	0	25	25
P-S	-8.1131	9.7171	-145.989	-144.385	47	18	7	6300	2	10	10

Interface residues

• A-B: ALA33B, ALA446B, ALA447B, ALA510B, ALA537B, ALA539A, ALA572A, ALA580A, ALA590A, ALA596A, ARG415B, ARG419B, ARG464A, ARG520B, ARG522B, ARG528B, ARG579A, ARG585A, ARG608A, ASN471A, ASN516B, ASN571A, ASP416B, ASP513B, ASP515B, ASP518B, ASP521B, ASP533B, ASP566A, ASP573A, ASP593A, GLN467A, GLN479B, GLN481B, GLN512B, GLN568A, GLN577A, GLN578A, GLU17B, GLU21B, GLU454B, GLU459A, GLU460A, GLU506A, GLU539B, GLU544B, GLU550B, GLU551B, GLU575A, GLU582A, GLU600A, GLU601A, GLY505A, GLY523B, HIS474B, ILE382B, ILE451B, ILE466A, ILE468A, ILE470A, ILE525B, ILE546A, ILE548B, ILE594A, LEU18B, LEU482B, LEU484B, LEU485B, LEU509B, LEU519B, LEU529B, LEU530B, LEU540A, LEU541A, LEU542A, LEU542B, LEU547B, LEU569A, LEU576A, LEU584A, LEU586A, LEU595A, LEU599A, LYS24A, LYS36B, LYS420B, LYS490B, LYS498A, LYS538B, LYS545B, LYS547A, LYS570A, MET602A, PHE605A, PRO517B, PRO534B, PRO536A, PRO546B, PRO603A, PRO604A, PRO606A, SER508B, SER514B, SER531B, SER543A, SER543B, SER549B, SER567A, SER587A, SER591A, THR478B, THR483B, THR486B, THR511B, THR532B, THR536B, THR537A, THR544A, THR588A, THR597A, TRP450B, TRP462A, TRP527B, TYR463A, TYR502A, TYR524B, TYR526B, TYR583A, VAL412B, VAL465A, VAL489B, VAL499A, VAL535A, VAL535B, VAL540B, VAL541B, VAL574A, VAL581A, VAL589A, VAL598A
• A-E: ARG277A, ARG528E, ASN325A, ASP321A, ASP475E, ASP513E, ASP533E, GLN500E, GLN504E, GLN505E, GLN512E, GLU272A, GLU323A, GLU360A, GLU464E, GLU467E, GLU471E, GLU501E, GLY472E, GLY621A, HIS320A, HIS363A, HIS474E, LEU327A, LEU470E, LEU502E, LEU509E, LEU529E, LEU530E, LEU616A, LYS223A, LYS538E, LYS615A, LYS617A, LYS618A, LYS619A, LYS620A, PHE361A, PHE473E, PRO269A, PRO270A, PRO271A, PRO274A, PRO324A, PRO534E, SER322A, SER359A, SER468E, SER497E, SER508E, SER531E, THR511E, THR532E, THR536E, TRP527E, TYR524E, TYR526E, VAL506E, VAL535E
• A-L: ALA436A, ALA436L, ALA596A, ALA596L, ARG399A, ARG399L, ARG472A, ARG472L, ARG608A, ARG608L, ASN325A, ASN325L, ASN471A, ASN471L, ASP398A, ASP398L, ASP473A, ASP473L, ASP474A, ASP474L, ASP593A, ASP593L, GLU323A, GLU323L, GLU360A, GLU360L, GLU364A, GLU364L, GLU600A, GLU600L, GLU601A, GLU601L, GLU607A, GLU609A, GLU609L, HIS363A, HIS363L, ILE468L, ILE594A, ILE594L, ILE612A, ILE612L, LEU326L, LEU327A, LEU327L, LEU595A, LEU595L, LEU599A, LEU599L, LEU613L, LYS615A, LYS615L, LYS617A, LYS617L, PHE361A, PHE361L, PRO324A, PRO324L, PRO603A, PRO603L, PRO604A, PRO604L, SER322A, SER322L, SER362A, SER362L, SER400A, SER400L, SER591A, SER591L, SER610A, SER610L, SER611A, SER611L, THR597A, THR597L, TYR435A, TYR435L, TYR439A, TYR439L, VAL328A, VAL328L, VAL437A, VAL437L, VAL598A, VAL598L
• A-M: ALA215A, ALA342M, ALA346M, ALA350M, ALA357A, ALA368M, ALA395A, ALA402A, ALA429A, ALA614A, ARG263A, ARG277A, ARG288M, ARG294M, ARG298M, ARG383M, ARG388A, ARG421A, ARG464A, ARG608A, ASN103M, ASN376M, ASN401A, ASP321A, ASP377M, ASP391A, ASP398A, ASP417A, ASP455A, CYS267A, CYS337M, CYS354A, CYS397A, GLN188M, GLN190M, GLN216A, GLN266A, GLN334M, GLN365M, GLN387A, GLU220A, GLU272A, GLU27A, GLU295M, GLU302M, GLU360A, GLU363M, GLU364A, GLU369M, GLU371M, GLU422A, GLU423A, GLU433A, GLU459A, GLU460A, GLU609A, GLU99M, GLY189M, GLY297M, GLY332M, GLY621A, GLY622A, HIS319A, HIS320A, ILE290M, ILE307M, ILE30A, ILE318A, ILE336M, ILE351M, ILE366M, ILE370M, ILE405A, ILE420A, ILE424A, ILE430A, ILE612A, LEU264A, LEU265A, LEU292M, LEU301M, LEU316A, LEU327A, LEU356A, LEU373M, LEU393A, LEU426A, LEU431A, LEU613A, LEU616A, LYS102M, LYS26A, LYS300M, LYS304M, LYS308M, LYS339M, LYS341M, LYS343M, LYS345M, LYS362M, LYS367A, LYS378M, LYS379M, LYS380M, LYS427A, LYS434A, LYS615A, LYS617A, LYS619A, LYS620A, MET185M, MET338M, MET396A, PHE361A, PRO187M, PRO219A, PRO269A, PRO270A, PRO291M, PRO374M, SER186M, SER322A, SER331M, SER347M, SER358A, SER359A, SER362A, SER364M, SER367M, SER384A, SER419A, SER458A, SER610A, SER611A, SER623A, THR212A, THR299M, THR326M, THR330M, THR355A, THR375M, TRP353M, TRP381M, TYR268A, TYR344M, TYR394A, TYR412A, TYR418A, TYR435A, TYR456A, TYR463A, VAL191M, VAL289M, VAL293M, VAL296M, VAL303M, VAL305M, VAL306M, VAL333M, VAL335M, VAL352M, VAL383A, VAL390A, VAL425A, VAL428A, VAL457A, VAL461A
• A-P: ARG21A, GLN301A, GLU4P, LEU9P, MET2P, TYR250A
• A-S: ALA11S, ALA120S, ALA136A, ALA14A, ALA168A, ALA169A, ALA17S, ALA206A, ALA254A, ALA305A, ALA308A, ALA313A, ALA349A, ALA3A, ALA44S, ALA79S, ALA83S, ARG11A, ARG124S, ARG141A, ARG15S, ARG174A, ARG177A, ARG21A, ARG263A, ARG346A, ARG381A, ARG388A, ARG3S, ARG42S, ARG60S, ARG87A, ASN106S, ASN124A, ASN137A, ASN22A, ASN304A, ASN307A, ASN344A, ASN48S, ASN74S, ASN76S, ASN77S, ASN86A, ASN86S, ASN9S, ASP115S, ASP162A, ASP19A, ASP246A, ASP25S, ASP382A, ASP43S, ASP71A, ASP72S, ASP75S, ASP8A, CYS134A, CYS171A, CYS60A, GLN128S, GLN134S, GLN139S, GLN166A, GLN216A, GLN22S, GLN245A, GLN266A, GLN29S, GLN301A, GLN92A, GLU100S, GLU116S, GLU122S, GLU125S, GLU142A, GLU142S, GLU29A, GLU312A, GLU342A, GLU351A, GLU380A, GLU51S, GLU82S, GLU89S, GLU90A, GLY121S, GLY129A, GLY139A, GLY202A, GLY69A, GLY7A, GLY9A, HIS133A, HIS200A, HIS302A, HIS46S, HIS70A, HIS85S, ILE123S, ILE135A, ILE17A, ILE20A, ILE2S, ILE314A, ILE32S, ILE58S, ILE65A, ILE72A, ILE84S, ILE93A, LEU101A, LEU101S, LEU103S, LEU119S, LEU130A, LEU132A, LEU135S, LEU136S, LEU138S, LEU13A, LEU141S, LEU16S, LEU170A, LEU172A, LEU173A, LEU175A, LEU201A, LEU210A, LEU244A, LEU257A, LEU262A, LEU310A, LEU345A, LEU348A, LEU62A, LEU63A, LEU67A, LEU68A, LEU78S, LEU81S, LEU96A, LYS109S, LYS130S, LYS133S, LYS13S, LYS165A, LYS18S, LYS260A, LYS26A, LYS28S, LYS299A, LYS306A, LYS45S, LYS56A, LYS56S, LYS61A, LYS6A, LYS91A, MET10A, MET117S, MET137S, MET143A, MET161A, MET1S, MET21S, PHE105S, PHE107S, PHE118S, PHE127A, PHE16A, PHE23S, PHE311A, PHE337A, PHE49S, PHE64A, PHE66A, PHE87S, PHE97A, PRO125A, PRO255A, SER127S, SER140A, SER140S, SER163A, SER167A, SER18A, SER209A, SER258A, SER303A, SER315A, SER384A, SER5A, SER85A, SER99A, THR112S, THR126A, THR126S, THR129S, THR14S, THR178A, THR205A, THR208A, THR212A, THR213A, THR248A, THR343A, THR47S, THR89A, TRP19S, TRP256A, TYR108S, TYR111S, TYR20S, TYR247A, TYR249A, TYR250A, TYR347A, TYR53A, TYR59S, TYR62S, TYR80S, TYR88A, TYR94S, VAL100A, VAL102A, VAL104S, VAL110S, VAL113S, VAL114S, VAL131S, VAL138A, VAL15A, VAL164A, VAL203A, VAL252A, VAL259A, VAL300A, VAL309A, VAL383A, VAL385A, VAL4A, VAL50S, VAL59A, VAL71S, VAL73S, VAL90S
• A-U: ARG608A, CYS337U, GLN334U, GLU369U, GLU371U, GLU607A, GLU609A, GLY340U, ILE336U, ILE612A, LEU616A, LYS300U, LYS341U, LYS615A, LYS617A, PHE605A, PRO603A, PRO604A, PRO606A, SER610A, SER623A, THR299U, VAL296U, VAL335U
• B-L: ARG277L, ARG528B, ASN325L, ASP321L, ASP475B, ASP513B, ASP533B, GLN500B, GLN504B, GLN505B, GLN512B, GLU272L, GLU323L, GLU360L, GLU464B, GLU467B, GLU471B, GLU501B, GLY472B, GLY621L, HIS320L, HIS474B, LEU327L, LEU470B, LEU502B, LEU509B, LEU529B, LEU530B, LEU616L, LYS223L, LYS538B, LYS615L, LYS617L, LYS618L, LYS619L, LYS620L, PHE361L, PHE473B, PRO269L, PRO270L, PRO271L, PRO274L, PRO324L, PRO534B, SER322L, SER359L, SER468B, SER497B, SER508B, SER531B, THR511B, THR532B, THR536B, TRP527B, TYR524B, TYR526B, VAL506B, VAL535B
• B-M: ALA104B, ALA141B, ALA142B, ALA146B, ALA178B, ALA180B, ALA182B, ALA183B, ALA251B, ALA254B, ALA259B, ALA302B, ALA317M, ALA359M, ALA362B, ALA39B, ALA444B, ALA51M, ALA571B, ALA580B, ALA75M, ALA76M, ALA77B, ARG108B, ARG114B, ARG18M, ARG21M, ARG304B, ARG357M, ARG371B, ARG375B, ARG402M, ARG423M, ARG445B, ARG44M, ARG52M, ARG60M, ASN104M, ASN123M, ASN173B, ASN179B, ASN217M, ASN252B, ASN305B, ASN329B, ASN404B, ASN49M, ASN516B, ASN579B, ASN62B, ASN72M, ASN74M, ASN75B, ASN99B, ASP113M, ASP117M, ASP134B, ASP150B, ASP224B, ASP22M, ASP23M, ASP330B, ASP366B, ASP368B, ASP415M, ASP417M, ASP437B, ASP440B, ASP443B, ASP475B, ASP515B, CYS112B, CYS144B, CYS214B, CYS337M, GLN122M, GLN135M, GLN136M, GLN219B, GLN299B, GLN318M, GLN400B, GLN408B, GLN479B, GLN481B, GLN71M, GLU110M, GLU114M, GLU125M, GLU186B, GLU189B, GLU216B, GLU260M, GLU295B, GLU297B, GLU32B, GLU337B, GLU357B, GLU360B, GLU364B, GLU409B, GLU441B, GLU476B, GLU64B, GLU80M, GLY111B, GLY119M, GLY215M, GLY218B, GLY294B, GLY340M, GLY360M, GLY3M, GLY472B, GLY4M, GLY568B, HIS149B, HIS250B, HIS416M, HIS474B, HIS566B, HIS57M, ILE102B, ILE108M, ILE115M, ILE133M, ILE138M, ILE151B, ILE16M, ILE187B, ILE220B, ILE2M, ILE332B, ILE336M, ILE355M, ILE38B, ILE419M, ILE50M, ILE567B, LEU101B, LEU105B, LEU107M, LEU111M, LEU112M, LEU116M, LEU129M, LEU148B, LEU15M, LEU165B, LEU173M, LEU175M, LEU184B, LEU223B, LEU257B, LEU291B, LEU315M, LEU316M, LEU336B, LEU399M, LEU404M, LEU439B, LEU570B, LEU63B, LEU65B, LEU68B, LEU71B, LEU73B, LEU82M, LYS102M, LYS130M, LYS139B, LYS147B, LYS213M, LYS256M, LYS261B, LYS312M, LYS31B, LYS327B, LYS335B, LYS339M, LYS341M, LYS354M, LYS356M, LYS35B, LYS362M, LYS372B, LYS400M, LYS402B, LYS405M, LYS420M, LYS576B, LYS59M, LYS66B, LYS67B, LYS70M, LYS78B, LYS84M, MET175B, MET1M, MET216M, MET338M, MET358M, MET41B, MET74B, MET77M, MET85M, PHE105M, PHE118M, PHE132M, PHE174M, PHE214M, PHE221B, PHE369B, PHE394M, PHE407M, PHE469B, PHE473B, PHE55M, PHE56M, PHE581B, PHE79M, PHE81M, PRO100B, PRO121M, PRO174B, PRO296B, PRO313M, PRO331B, PRO393M, PRO442B, PRO46M, PRO577B, PRO578B, PRO81B, SER124M, SER17M, SER185B, SER253B, SER258B, SER262M, SER314M, SER364M, SER414M, SER438B, SER45M, SER477B, SER54M, SER569B, SER572B, SER79B, THR109B, THR131M, THR134M, THR140B, THR215B, THR363B, THR401B, THR42B, THR478B, THR48M, THR53M, THR69M, TRP217B, TRP421M, TYR109M, TYR120M, TYR136B, TYR20M, TYR300B, TYR328B, TYR333B, TYR361B, TYR403M, TYR405B, TYR424M, TYR574B, TYR70B, TYR76B, TYR83M, VAL106M, VAL107B, VAL137B, VAL143B, VAL14M, VAL176B, VAL177M, VAL181B, VAL19M, VAL255B, VAL256B, VAL298B, VAL301B, VAL326B, VAL334B, VAL34B, VAL365B, VAL367B, VAL370B, VAL401M, VAL403B, VAL406M, VAL418M, VAL422M, VAL43B, VAL43M, VAL47M, VAL480B, VAL573B, VAL582B, VAL58M, VAL68M, VAL73M, VAL78M
• B-P: GLU14B, GLY13B, ILE5P, LYS12B, LYS45B, MET2P
• B-U: ARG298U, ARG528B, ASN329U, ASN376U, ASP377U, ASP513B, GLN500B, GLN504B, GLN505B, GLN512B, GLU371U, GLU501B, GLY297U, GLY332U, LEU372U, LEU373U, LEU502B, LEU507B, LEU509B, LEU530B, LYS300U, LYS378U, PHE492B, PRO374U, PRO534B, SER331U, SER508B, SER531B, THR299U, THR330U, THR375U, THR511B, THR532B, TRP527B, TYR524B, VAL503B, VAL506B
• E-L: ALA33E, ALA39E, ALA446E, ALA447E, ALA487E, ALA510E, ALA537E, ALA539L, ALA572L, ALA580L, ALA590L, ALA596L, ARG415E, ARG419E, ARG464L, ARG520E, ARG522E, ARG528E, ARG564L, ARG579L, ARG585L, ARG608L, ASN471L, ASN516E, ASN571L, ASP416E, ASP513E, ASP515E, ASP518E, ASP521E, ASP533E, ASP566L, ASP573L, GLN467L, GLN479E, GLN481E, GLN512E, GLN568L, GLN577L, GLN578L, GLU17E, GLU21E, GLU32E, GLU454E, GLU459L, GLU460L, GLU506L, GLU539E, GLU544E, GLU550E, GLU551E, GLU575L, GLU582L, GLU600L, GLU601L, GLY505L, GLY523E, HIS474E, ILE382E, ILE449E, ILE451E, ILE466L, ILE468L, ILE470L, ILE525E, ILE546L, ILE548E, ILE594L, LEU18E, LEU482E, LEU484E, LEU485E, LEU519E, LEU529E, LEU530E, LEU540L, LEU541L, LEU542E, LEU542L, LEU547E, LEU569L, LEU576L, LEU584L, LEU586L, LEU595L, LEU599L, LYS24L, LYS36E, LYS420E, LYS490E, LYS498L, LYS538E, LYS545E, LYS547L, LYS570L, MET602L, PHE605L, PRO517E, PRO534E, PRO536L, PRO546E, PRO603L, PRO604L, PRO606L, SER25L, SER514E, SER531E, SER543E, SER543L, SER549E, SER565L, SER567L, SER587L, SER591L, THR478E, THR483E, THR486E, THR511E, THR532E, THR536E, THR537L, THR544L, THR588L, THR597L, TRP450E, TRP462L, TRP527E, TYR463L, TYR502L, TYR524E, TYR526E, TYR583L, VAL412E, VAL465L, VAL480E, VAL489E, VAL499L, VAL535E, VAL535L, VAL540E, VAL541E, VAL574L, VAL581L, VAL589L, VAL598L
• E-M: ARG298M, ARG528E, ASN329M, ASN376M, ASP377M, ASP513E, GLN500E, GLN504E, GLN505E, GLN512E, GLU371M, GLU501E, GLY297M, GLY332M, LEU372M, LEU373M, LEU502E, LEU507E, LEU509E, LEU530E, LYS300M, PHE492E, PRO374M, PRO534E, SER331M, SER508E, SER531E, THR299M, THR375M, THR511E, THR532E, TRP527E, TYR524E, VAL503E, VAL506E
• E-Q: GLU14E, GLY13E, ILE15E, ILE5Q, LYS12E, LYS45E, MET2Q
• E-U: ALA104E, ALA141E, ALA142E, ALA146E, ALA178E, ALA180E, ALA182E, ALA183E, ALA251E, ALA254E, ALA259E, ALA302E, ALA317U, ALA359U, ALA362E, ALA39E, ALA444E, ALA51U, ALA571E, ALA580E, ALA75U, ALA76U, ALA77E, ARG108E, ARG114E, ARG18U, ARG21U, ARG304E, ARG357U, ARG371E, ARG375E, ARG402U, ARG423U, ARG445E, ARG44U, ARG52U, ARG60U, ASN123U, ASN173E, ASN179E, ASN217U, ASN252E, ASN305E, ASN329E, ASN404E, ASN49U, ASN516E, ASN579E, ASN62E, ASN72U, ASN74U, ASN75E, ASN99E, ASP113U, ASP117U, ASP134E, ASP150E, ASP224E, ASP22U, ASP23U, ASP330E, ASP366E, ASP368E, ASP415U, ASP417U, ASP437E, ASP440E, ASP443E, ASP475E, ASP515E, CYS112E, CYS144E, CYS214E, CYS337U, GLN122U, GLN135U, GLN136U, GLN219E, GLN299E, GLN318U, GLN400E, GLN408E, GLN479E, GLN481E, GLN71U, GLU110U, GLU114U, GLU125U, GLU186E, GLU189E, GLU216E, GLU260U, GLU295E, GLU297E, GLU32E, GLU337E, GLU357E, GLU360E, GLU364E, GLU409E, GLU441E, GLU476E, GLU64E, GLU80U, GLY111E, GLY119U, GLY215U, GLY218E, GLY294E, GLY340U, GLY360U, GLY3U, GLY472E, GLY4U, GLY568E, HIS149E, HIS250E, HIS416U, HIS474E, HIS566E, HIS57U, ILE108U, ILE115U, ILE133U, ILE151E, ILE16U, ILE187E, ILE220E, ILE2U, ILE332E, ILE336U, ILE355U, ILE38E, ILE419U, ILE50U, ILE567E, LEU101E, LEU105E, LEU107U, LEU111U, LEU112U, LEU116U, LEU129U, LEU148E, LEU15U, LEU165E, LEU173U, LEU175U, LEU184E, LEU223E, LEU257E, LEU291E, LEU315U, LEU316U, LEU336E, LEU399U, LEU404U, LEU439E, LEU570E, LEU63E, LEU65E, LEU68E, LEU71E, LEU73E, LEU82U, LYS102U, LYS130U, LYS139E, LYS147E, LYS213U, LYS256U, LYS261E, LYS312U, LYS31E, LYS327E, LYS335E, LYS339U, LYS341U, LYS354U, LYS356U, LYS35E, LYS362U, LYS372E, LYS400U, LYS402E, LYS405U, LYS420U, LYS576E, LYS59U, LYS66E, LYS67E, LYS70U, LYS78E, LYS84U, MET175E, MET1U, MET216U, MET338U, MET358U, MET41E, MET74E, MET77U, MET85U, PHE105U, PHE118U, PHE132U, PHE174U, PHE214U, PHE221E, PHE369E, PHE394U, PHE407U, PHE469E, PHE473E, PHE55U, PHE56U, PHE581E, PHE79U, PHE81U, PRO100E, PRO121U, PRO174E, PRO296E, PRO313U, PRO331E, PRO393U, PRO442E, PRO46U, PRO577E, PRO578E, PRO81E, SER124U, SER17U, SER185E, SER253E, SER258E, SER262U, SER314U, SER438E, SER45U, SER477E, SER54U, SER569E, SER572E, SER79E, THR109E, THR131U, THR134U, THR140E, THR215E, THR363E, THR401E, THR42E, THR478E, THR48U, THR53U, THR69U, TRP217E, TRP421U, TYR109U, TYR120U, TYR136E, TYR20U, TYR300E, TYR328E, TYR333E, TYR361E, TYR403U, TYR405E, TYR424U, TYR574E, TYR70E, TYR76E, TYR83U, VAL106U, VAL107E, VAL137E, VAL143E, VAL145E, VAL14U, VAL176E, VAL177U, VAL181E, VAL19U, VAL255E, VAL256E, VAL298E, VAL301E, VAL326E, VAL334E, VAL34E, VAL365E, VAL367E, VAL370E, VAL401U, VAL403E, VAL406U, VAL418U, VAL422U, VAL43E, VAL43U, VAL47U, VAL480E, VAL573E, VAL582E, VAL58U, VAL68U, VAL73U, VAL78U
• I-L: ALA11I, ALA120I, ALA136L, ALA144L, ALA14L, ALA168L, ALA169L, ALA17I, ALA206L, ALA254L, ALA305L, ALA308L, ALA313L, ALA3L, ALA44I, ALA79I, ALA83I, ARG11L, ARG124I, ARG141L, ARG15I, ARG174L, ARG177L, ARG21L, ARG263L, ARG346L, ARG381L, ARG388L, ARG3I, ARG42I, ARG60I, ARG87L, ASN106I, ASN124L, ASN137L, ASN22L, ASN304L, ASN307L, ASN344L, ASN48I, ASN74I, ASN76I, ASN77I, ASN86I, ASN86L, ASN9I, ASP115I, ASP162L, ASP19L, ASP246L, ASP25I, ASP382L, ASP43I, ASP71L, ASP72I, ASP75I, ASP8L, CYS134L, CYS171L, CYS60L, GLN128I, GLN134I, GLN139I, GLN166L, GLN216L, GLN22I, GLN245L, GLN266L, GLN29I, GLN301L, GLN92L, GLU100I, GLU116I, GLU122I, GLU125I, GLU142I, GLU142L, GLU29L, GLU312L, GLU342L, GLU351L, GLU380L, GLU51I, GLU82I, GLU89I, GLU90L, GLY121I, GLY129L, GLY139L, GLY202L, GLY69L, GLY7L, GLY9L, HIS133L, HIS200L, HIS302L, HIS46I, HIS70L, HIS85I, ILE123I, ILE135L, ILE17L, ILE20L, ILE2I, ILE314L, ILE32I, ILE58I, ILE65L, ILE72L, ILE84I, ILE93L, LEU101I, LEU101L, LEU103I, LEU119I, LEU130L, LEU132L, LEU135I, LEU136I, LEU138I, LEU13L, LEU141I, LEU16I, LEU170L, LEU172L, LEU173L, LEU175L, LEU201L, LEU210L, LEU257L, LEU262L, LEU310L, LEU345L, LEU348L, LEU62L, LEU63L, LEU67L, LEU68L, LEU78I, LEU81I, LEU96L, LYS109I, LYS130I, LYS133I, LYS13I, LYS165L, LYS18I, LYS260L, LYS26L, LYS28I, LYS299L, LYS306L, LYS45I, LYS56I, LYS56L, LYS57L, LYS61L, LYS6L, LYS91L, MET10L, MET117I, MET137I, MET143L, MET1I, MET21I, PHE105I, PHE107I, PHE118I, PHE127L, PHE16L, PHE23I, PHE311L, PHE337L, PHE49I, PHE64L, PHE66L, PHE87I, PHE97L, PRO125L, PRO255L, SER127I, SER140I, SER140L, SER163L, SER167L, SER18L, SER209L, SER258L, SER303L, SER315L, SER384L, SER5L, SER85L, SER99L, THR112I, THR126I, THR126L, THR129I, THR14I, THR178L, THR205L, THR208L, THR212L, THR213L, THR248L, THR343L, THR47I, THR89L, TRP19I, TRP256L, TYR108I, TYR111I, TYR20I, TYR247L, TYR249L, TYR250L, TYR347L, TYR53L, TYR59I, TYR62I, TYR80I, TYR88L, TYR94I, VAL100L, VAL102L, VAL104I, VAL110I, VAL113I, VAL114I, VAL131I, VAL138L, VAL15L, VAL164L, VAL203L, VAL252L, VAL259L, VAL300L, VAL309L, VAL383L, VAL385L, VAL4L, VAL50I, VAL59L, VAL71I, VAL73I, VAL88I, VAL90I
• I-Q: ALA11I, ALA63I, ARG10I, ARG15I, ARG60I, ARG61I, ARG7Q, ASN86I, ASN92I, ASN97I, ASN9I, ASP102I, CYS99I, GLN128I, GLN8I, GLU100I, GLU4Q, GLU89I, GLU93I, GLY12I, GLY64I, HIS36I, HIS85I, HIS96I, ILE5Q, ILE7I, ILE84I, LEU101I, LEU103I, LEU65I, LEU8Q, LEU91I, LEU9Q, LYS13I, LYS6Q, MET2Q, PHE105I, PHE67I, PHE87I, PHE95I, SER10Q, TYR62I, TYR66I, VAL104I, VAL88I, VAL90I, VAL98I
• I-U: ALA194U, ALA242U, ALA382U, ARG278U, ARG3I, ARG42I, ARG434U, ARG53I, ASN54I, ASN74I, ASP244U, ASP245U, ASP24I, ASP25I, ASP26I, ASP72I, GLN188U, GLN190U, GLN22I, GLN239U, GLN29I, GLU27I, GLU33I, GLU34I, GLU432U, GLU51I, GLY189U, GLY237U, HIS195U, ILE241U, ILE243U, ILE32I, ILE430U, LEU184U, LEU192U, LEU31I, LYS11U, LYS238U, LYS281U, LYS28I, LYS30I, LYS380U, LYS56I, MET185U, MET1I, MET21I, PHE23I, PHE4I, PHE52I, PHE55I, PRO187U, SER186U, SER193U, SER240U, THR233U, THR279U, THR280U, TRP19I, VAL191U, VAL38I, VAL50I, VAL73I
• L-M: ARG608L, CYS337M, GLN334M, GLU369M, GLU371M, GLU607L, GLU609L, GLY340M, ILE336M, ILE612L, LEU616L, LYS300M, LYS341M, LYS615L, LYS617L, MET338M, PHE605L, PRO603L, PRO604L, PRO606L, SER610L, SER623L, THR299M, VAL296M, VAL335M
• L-Q: ARG21L, GLN301L, GLU4Q, LEU9Q, MET2Q, TYR250L
• L-U: ALA215L, ALA342U, ALA346U, ALA350U, ALA357L, ALA368U, ALA395L, ALA429L, ALA614L, ARG263L, ARG277L, ARG288U, ARG294U, ARG298U, ARG383U, ARG388L, ARG421L, ARG464L, ARG608L, ASN103U, ASN376U, ASN401L, ASP321L, ASP377U, ASP391L, ASP398L, ASP417L, ASP455L, CYS267L, CYS337U, CYS354L, CYS397L, GLN188U, GLN190U, GLN216L, GLN266L, GLN334U, GLN365U, GLN387L, GLN467L, GLU220L, GLU272L, GLU27L, GLU295U, GLU302U, GLU360L, GLU363U, GLU364L, GLU369U, GLU371U, GLU422L, GLU423L, GLU433L, GLU459L, GLU460L, GLU609L, GLU99U, GLY189U, GLY297U, GLY332U, GLY621L, GLY622L, HIS319L, HIS320L, ILE290U, ILE307U, ILE318L, ILE336U, ILE351U, ILE366U, ILE370U, ILE420L, ILE424L, ILE430L, ILE612L, LEU265L, LEU292U, LEU301U, LEU327L, LEU356L, LEU373U, LEU393L, LEU426L, LEU431L, LEU613L, LEU616L, LYS102U, LYS26L, LYS300U, LYS304U, LYS308U, LYS339U, LYS341U, LYS343U, LYS345U, LYS362U, LYS367L, LYS378U, LYS379U, LYS380U, LYS427L, LYS434L, LYS615L, LYS617L, LYS619L, LYS620L, MET185U, MET338U, MET396L, PHE361L, PRO187U, PRO219L, PRO269L, PRO270L, PRO291U, PRO374U, SER186U, SER322L, SER331U, SER347U, SER358L, SER359L, SER362L, SER364U, SER367U, SER384L, SER419L, SER458L, SER610L, SER611L, SER623L, THR212L, THR299U, THR326U, THR330U, THR355L, THR375U, TRP353U, TRP381U, TYR268L, TYR344U, TYR347L, TYR394L, TYR412L, TYR418L, TYR435L, TYR456L, TYR463L, VAL191U, VAL289U, VAL293U, VAL296U, VAL303U, VAL305U, VAL306U, VAL333U, VAL335U, VAL352U, VAL383L, VAL390L, VAL425L, VAL428L, VAL457L, VAL461L
• M-S: ALA194M, ALA242M, ALA382M, ARG278M, ARG3S, ARG42S, ARG434M, ARG53S, ASN54S, ASN74S, ASP244M, ASP245M, ASP24S, ASP25S, ASP26S, ASP72S, CYS70S, GLN188M, GLN190M, GLN22S, GLN239M, GLN29S, GLU27S, GLU33S, GLU34S, GLU432M, GLU51S, GLY189M, GLY237M, HIS195M, ILE241M, ILE243M, ILE32S, ILE430M, LEU184M, LEU192M, LEU31S, LYS11M, LYS238M, LYS281M, LYS28S, LYS30S, LYS380M, LYS56S, MET185M, MET1S, MET21S, PHE23S, PHE4S, PHE52S, PHE55S, PRO187M, SER186M, SER193M, SER236M, SER240M, THR233M, THR279M, THR280M, TRP19S, VAL191M, VAL38S, VAL50S, VAL73S
• P-S: ALA11S, ALA63S, ARG10S, ARG15S, ARG60S, ARG61S, ARG7P, ASN86S, ASN92S, ASN97S, ASN9S, ASP102S, CYS99S, GLN128S, GLN8S, GLU100S, GLU4P, GLU89S, GLU93S, GLY12S, GLY64S, HIS36S, HIS85S, HIS96S, ILE5P, ILE7S, ILE84S, LEU101S, LEU103S, LEU65S, LEU8P, LEU91S, LEU9P, LYS13S, LYS6P, MET2P, PHE105S, PHE67S, PHE87S, PHE95S, SER10P, TYR62S, TYR66S, VAL104S, VAL88S, VAL90S, VAL98S