2JJT

structure of human cd47 in complex with human signal regulatory protein (sirp) alpha

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 79
  • Norm. En. per Res.: -5.8923
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	8.5305	-99.8105	-91.28	66	2	3	4924	0	20	25
A-C	-98.7153	-100.9732	-265.803	-465.4915	79	15	5	10201	13	38	28
A-D	0.0	-3.1043	-15.9496	-19.0539	36	0	0	960	0	12	13
B-C	0.0	-1.631	-15.8777	-17.5087	35	0	0	944	0	13	17
B-D	-73.7782	-113.5473	-255.465	-442.7906	84	7	5	9974	14	40	29

Interface residues

• A-B: ALA42A, ALA42B, ALA45A, ALA45B, ALA84A, ALA84B, ARG40A, ARG40B, ARG46A, ARG46B, ARG59A, ARG59B, ARG95A, ARG95B, ASN51A, ASN51B, ASP100A, ASP100B, ASP85B, GLN37A, GLN37B, GLU102A, GLU102B, GLU47A, GLU47B, GLU54A, GLU54B, GLY41B, GLY43A, GLY43B, GLY55A, GLY55B, GLY97B, HIS56A, HIS56B, ILE49A, ILE49B, LEU48A, LEU48B, LYS53A, LYS53B, LYS96A, LYS96B, PHE103A, PHE39A, PHE39B, PHE57A, PHE57B, PHE94A, PHE94B, PRO35A, PRO35B, PRO44A, PRO44B, PRO58A, PRO58B, PRO99A, PRO99B, SER98A, SER98B, THR101A, THR101B, THR82B, TYR89B, VAL92A, VAL92B
• A-C: ALA30C, ALA53C, ARG103C, ARG45C, ARG69A, ARG95A, ASN27C, ASN32C, ASN51A, ASN71A, ASP100A, ASP46C, ASP51C, CYS96C, GLN31C, GLN37A, GLN52A, GLU100C, GLU104C, GLU106C, GLU29C, GLU35C, GLU54A, GLU65A, GLU70A, GLU97C, GLY105C, GLY34A, GLY52C, GLY55A, GLY97A, ILE31A, ILE36A, LEU101C, LEU2C, LEU30A, LEU3C, LEU4A, LEU54C, LEU74C, LYS39C, LYS41C, LYS53A, LYS68A, LYS6C, LYS93A, LYS96A, MET28C, MET72A, PHE4C, PHE50C, PHE57A, PHE74A, PHE94A, PRO32A, PRO35A, PRO99A, SER29A, SER66A, SER98A, THR101A, THR102C, THR107C, THR33C, THR34C, THR49C, THR58C, THR67A, THR95C, THR99C, TYR37C, TYR48C, TYR50A, VAL27A, VAL33A, VAL36C, VAL38C, VAL92A, VAL98C
• A-D: ALA107A, ALA42A, ALA45A, ALA84A, ALA86A, ARG40A, ARG45D, ARG46A, ASN93D, GLU104D, GLU106D, GLU110A, GLU110D, GLU97D, GLY108A, GLY41A, GLY43A, GLY44D, GLY87A, GLY92D, ILE108D, LEU111A, LYS11A, LYS39D, LYS41D, LYS43D, LYS8D, PHE42D, PRO44A, PRO83A, SER112A, SER12A, THR88A, THR95D, TYR90A, VAL113A
• B-C: ALA107B, ALA115B, ALA42B, ALA45B, ALA84B, ALA86B, ARG114B, ARG40B, ARG45C, ASN93C, GLU104C, GLU106C, GLU110B, GLU110C, GLY108B, GLY41B, GLY44C, GLY87B, GLY92C, ILE108C, LEU111B, LYS11B, LYS39C, LYS41C, LYS43C, LYS8C, PHE42C, PRO83B, SER112B, SER12B, THR109B, THR88B, THR95C, TYR90B, VAL113B
• B-D: ALA30D, ALA53D, ARG103D, ARG69B, ARG95B, ASN27D, ASN32D, ASN51B, ASN71B, ASP100B, ASP46D, ASP51D, CYS96D, GLN31D, GLN37B, GLN52B, GLU100D, GLU104D, GLU106D, GLU29D, GLU35D, GLU54B, GLU65B, GLU70B, GLU97D, GLY105D, GLY34B, GLY52D, GLY55B, GLY97B, HIS56B, ILE108D, ILE31B, ILE36B, ILE47D, LEU101D, LEU2D, LEU30B, LEU3D, LEU48B, LEU4B, LEU54D, LEU74D, LYS39D, LYS41D, LYS53B, LYS68B, LYS6D, LYS93B, LYS96B, MET28D, MET72B, PHE4D, PHE50D, PHE57B, PHE74B, PHE94B, PRO32B, PRO35B, PRO60D, PRO99B, SER29B, SER66B, SER98B, THR101B, THR102D, THR107D, THR33D, THR34D, THR49D, THR58D, THR67B, THR95D, THR99D, TYR37D, TYR48D, TYR50B, VAL27B, VAL33B, VAL36D, VAL38D, VAL59D, VAL92B, VAL98D