2JJS

structure of human cd47 in complex with human signal regulatory protein (sirp) alpha

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 81
  • Norm. En. per Res.: -6.334
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	21.599	-2.5518	19.0472	8	0	0	133	0	4	4
A-C	-86.5976	-129.8401	-249.62	-466.0577	82	8	5	9976	13	39	28
A-D	-6.1691	-14.6436	-19.0297	-39.8424	33	1	0	1211	1	9	9
B-C	-11.6049	-18.1931	-18.486	-48.2839	33	5	0	1223	1	9	9
B-D	-121.7003	-133.9456	-257.411	-513.0568	81	11	5	9876	13	39	27
C-D	0.0	0.0	-2.541	-2.541	8	1	0	170	0	0	3

Interface residues

• A-B: GLU54A, GLU54B, GLY55A, GLY55B, HIS56A, HIS56B, PRO58A, PRO58B
• A-C: ALA30C, ALA53C, ARG103C, ARG45C, ARG69A, ARG95A, ASN27C, ASN32C, ASN51A, ASN71A, ASP100A, ASP46C, ASP51C, CYS96C, GLN31C, GLN37A, GLN52A, GLU100C, GLU104C, GLU106C, GLU29C, GLU35C, GLU54A, GLU65A, GLU70A, GLU97C, GLY105C, GLY34A, GLY52C, GLY55A, GLY97A, HIS56A, ILE108C, ILE31A, ILE36A, LEU101C, LEU2C, LEU30A, LEU3C, LEU48A, LEU4A, LEU54C, LEU74C, LYS39C, LYS41C, LYS53A, LYS68A, LYS6C, LYS93A, LYS96A, MET28C, MET72A, PHE4C, PHE50C, PHE57A, PHE74A, PHE94A, PRO32A, PRO35A, PRO99A, SER29A, SER66A, SER98A, THR101A, THR102C, THR107C, THR33C, THR34C, THR49C, THR58C, THR67A, THR95C, THR99C, TYR37C, TYR48C, TYR50A, VAL27A, VAL33A, VAL36C, VAL38C, VAL92A, VAL98C
• A-D: ARG59A, ASN71A, ASN80A, ASN93D, GLN52A, GLU110D, GLU19A, GLU54A, GLU65A, GLY18A, GLY92D, ILE108D, ILE22A, ILE76A, LYS112D, LYS43D, LYS68A, LYS6D, LYS8D, PRO58A, SER20A, SER64A, SER66A, SER75A, SER77A, SER79A, SER9D, THR61A, THR62A, THR67A, TYR50A, VAL60A, VAL63A
• B-C: ARG59B, ASN71B, ASN80B, ASN93C, GLN52B, GLU110C, GLU19B, GLU54B, GLU65B, GLY18B, GLY55B, GLY92C, ILE108C, ILE22B, ILE76B, LYS112C, LYS43C, LYS6C, LYS8C, PRO58B, SER20B, SER64B, SER66B, SER75B, SER77B, SER79B, SER9C, THR61B, THR62B, THR67B, TYR50B, VAL60B, VAL63B
• B-D: ALA30D, ALA53D, ARG103D, ARG45D, ARG69B, ARG95B, ASN27D, ASN32D, ASN51B, ASN71B, ASP100B, ASP46D, ASP51D, CYS96D, GLN31D, GLN37B, GLN52B, GLU100D, GLU104D, GLU106D, GLU29D, GLU35D, GLU54B, GLU65B, GLU70B, GLU97D, GLY105D, GLY34B, GLY52D, GLY97B, HIS56B, ILE108D, ILE31B, ILE36B, ILE47D, LEU101D, LEU2D, LEU30B, LEU3D, LEU48B, LEU4B, LEU74D, LYS39D, LYS41D, LYS53B, LYS68B, LYS6D, LYS93B, LYS96B, MET28D, MET72B, PHE4D, PHE50D, PHE57B, PHE74B, PHE94B, PRO32B, PRO35B, PRO99B, SER29B, SER66B, SER98B, THR101B, THR102D, THR107D, THR33D, THR34D, THR49D, THR58D, THR67B, THR95D, THR99D, TYR37D, TYR48D, TYR50B, VAL27B, VAL33B, VAL36D, VAL38D, VAL92B, VAL98D
• C-D: LEU3C, LEU3D, LYS6C, LYS6D, LYS8C, LYS8D, PHE4C, PHE4D