2JG7

crystal structure of seabream antiquitin and elucidation of its substrate specificity

• Total interactions analyzed: 28
• Total true interactions: 24
• Strongest Interaction:
  • Chains: A-H
  • Int. Res.: 12
  • Norm. En. per Res.: -4.1285
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-257.6178	-156.3151	-922.814	-1336.7469	338	30	12	37108	15	90	89
A-C	0.0	-27.6899	-201.393	-229.083	116	1	7	8818	0	46	33
A-D	-52.336	-67.3887	-216.981	-336.7058	94	5	6	9668	4	30	30
A-G	0.0	0.0	-0.0053	-0.0053	2	0	0	5	0	3	3
A-H	-18.4922	-27.735	-3.315	-49.5422	12	3	0	498	2	11	10
B-C	-55.9863	-69.9255	-232.108	-358.0198	98	8	7	10057	4	30	30
B-D	0.0	-28.6672	-202.015	-230.6822	111	3	7	8691	0	46	29
B-G	0.0	0.0	-0.0022	-0.0022	2	0	0	2	0	1	1
B-H	0.0	11.2499	-8.4478	2.8021	30	2	0	736	1	14	15
C-D	-238.6096	-156.5685	-895.555	-1290.7331	336	33	12	36690	16	92	89
C-E	0.0	-2.3344	-0.0006	-2.335	2	0	0	2	0	1	1
C-F	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	1	2
C-G	0.0	-18.1277	-7.903	-26.0307	16	0	0	618	2	2	3
C-H	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	2
D-E	0.0	20.0255	-13.1908	6.8347	33	1	0	904	0	16	17
D-F	0.0	-2.337	-2.4887	-4.8257	9	0	0	204	0	9	7
D-G	0.0	0.0	-0.0012	-0.0012	4	0	0	3	0	1	2
D-H	0.0	0.0	-0.0054	-0.0054	2	0	0	5	0	0	0
E-F	-246.2478	-156.3419	-925.411	-1328.0007	335	32	12	36943	14	90	87
E-G	-53.2452	-66.8934	-221.895	-342.0336	95	3	7	9841	4	31	30
E-H	0.0	-28.1661	-205.772	-233.9381	115	2	7	8959	0	46	30
F-G	0.0	-26.4164	-210.393	-236.8094	116	3	7	8985	0	46	32
F-H	-53.6408	-67.9121	-221.435	-342.9879	96	3	6	9762	4	28	30
G-H	-235.1441	-158.3259	-903.89	-1297.3601	336	33	12	36889	16	90	89

Interface residues

• A-B: ALA148A, ALA148B, ALA254A, ALA254B, ALA289A, ALA289B, ALA324A, ALA324B, ALA461A, ALA461B, ALA466A, ALA466B, ALA504A, ALA504B, ALA69A, ALA69B, ALA74A, ALA74B, ARG144A, ARG144B, ARG260A, ARG260B, ARG263A, ARG263B, ARG300A, ARG300B, ARG320A, ARG320B, ARG329A, ARG329B, ARG440A, ARG440B, ARG477A, ARG477B, ARG489A, ARG489B, ARG490A, ARG490B, ARG67A, ARG67B, ARG81A, ARG81B, ASN154A, ASN154B, ASN283A, ASN283B, ASN420A, ASN420B, ASN453A, ASN453B, ASN455A, ASN455B, ASN496A, ASN496B, ASP123A, ASP123B, ASP239A, ASP239B, ASP281A, ASP281B, ASP448A, ASP448B, ASP482A, ASP482B, ASP500A, ASP500B, ASP75A, ASP75B, CYS182A, CYS182B, CYS449A, CYS449B, CYS493A, CYS493B, GLN152A, GLN152B, GLN258A, GLN258B, GLN327A, GLN327B, GLN423A, GLN423B, GLN486A, GLN486B, GLN505A, GLN505B, GLU113B, GLU120A, GLU120B, GLU143A, GLU143B, GLU151A, GLU151B, GLU236A, GLU236B, GLU259A, GLU259B, GLU413A, GLU413B, GLU462A, GLU462B, GLU470A, GLU470B, GLU478A, GLU478B, GLU68B, GLY137A, GLY137B, GLY183A, GLY183B, GLY250A, GLY250B, GLY262A, GLY262B, GLY269A, GLY269B, GLY295A, GLY295B, GLY425A, GLY425B, GLY443A, GLY443B, GLY446A, GLY446B, GLY450A, GLY450B, GLY460A, GLY460B, GLY464A, GLY464B, GLY465A, GLY465B, GLY468A, GLY468B, GLY469A, GLY469B, GLY474A, GLY474B, GLY475A, GLY475B, GLY476A, GLY476B, GLY480A, GLY480B, GLY506A, GLY506B, HIS147A, HIS147B, HIS248A, HIS248B, HIS472A, HIS472B, ILE110A, ILE110B, ILE150A, ILE150B, ILE321A, ILE321B, ILE430A, ILE430B, ILE451A, ILE451B, ILE456A, ILE456B, ILE463A, ILE463B, ILE495A, ILE495B, ILE507A, ILE507B, ILE76A, ILE76B, LEU140A, LEU140B, LEU149A, LEU149B, LEU266A, LEU266B, LEU268A, LEU268B, LEU282A, LEU282B, LEU284A, LEU284B, LEU339A, LEU339B, LEU426A, LEU426B, LEU435A, LEU435B, LEU442A, LEU442B, LEU501A, LEU501B, LEU503A, LEU503B, LYS251A, LYS251B, LYS264A, LYS264B, LYS323A, LYS323B, LYS326A, LYS326B, LYS433A, LYS433B, LYS445A, LYS445B, LYS471A, LYS471B, LYS485A, LYS485B, LYS499A, LYS499B, LYS508A, LYS508B, LYS71A, LYS71B, MET252A, MET252B, MET255A, MET255B, MET256A, MET256B, MET488A, MET488B, MET72A, MET72B, PHE261A, PHE261B, PHE291A, PHE291B, PHE431A, PHE431B, PHE439A, PHE439B, PHE467A, PHE467B, PHE509A, PHE509B, PRO138A, PRO138B, PRO141A, PRO141B, PRO155A, PRO155B, PRO287A, PRO287B, PRO444A, PRO444B, PRO457A, PRO457B, PRO502A, PRO502B, PRO77A, PRO77B, SER142A, SER142B, SER246A, SER246B, SER288A, SER288B, SER337A, SER337B, SER427A, SER427B, SER428A, SER428B, SER429A, SER429B, SER447A, SER447B, SER459A, SER459B, SER481A, SER481B, SER483A, SER483B, SER491A, SER491B, SER498A, SER498B, THR247A, THR247B, THR338A, THR338B, THR432A, THR432B, THR473A, THR473B, THR492A, THR492B, THR494A, THR494B, TRP153A, TRP153B, TRP441A, TRP441B, TRP484A, TRP484B, TRP70A, TRP70B, TRP73A, TRP73B, TYR127A, TYR127B, TYR325A, TYR325B, TYR340A, TYR340B, TYR497A, TYR497B, VAL112A, VAL112B, VAL156A, VAL156B, VAL249A, VAL249B, VAL253A, VAL253B, VAL257A, VAL257B, VAL285A, VAL285B, VAL286A, VAL286B, VAL290A, VAL290B, VAL294A, VAL294B, VAL328A, VAL328B, VAL438A, VAL438B, VAL452A, VAL452B, VAL454A, VAL454B
• A-C: ALA128A, ALA128C, ALA148A, ALA148C, ALA461A, ALA461C, ARG133A, ARG133C, ARG437A, ARG437C, ARG440A, ARG440C, ARG86A, ARG86C, ARG93A, ARG93C, ASN496A, ASN496C, ASP123A, ASP123C, ASP126A, ASP126C, ASP434A, ASP434C, ASP482A, ASP482C, ASP90A, ASP90C, CYS125A, CYS125C, GLN119A, GLN119C, GLN87A, GLN87C, GLU120A, GLU120C, GLU412A, GLU462A, GLU462C, GLU83A, GLU83C, GLY130A, GLY130C, GLY146A, GLY146C, GLY436A, GLY436C, GLY443A, GLY443C, GLY464A, GLY464C, GLY465A, GLY465C, GLY480A, GLY480C, GLY82A, GLY82C, HIS147A, HIS147C, ILE135A, ILE135C, ILE150A, ILE150C, ILE463A, ILE463C, ILE495A, ILE495C, LEU131A, LEU131C, LEU149A, LEU149C, LEU435A, LEU435C, LEU442A, LEU442C, LYS445A, LYS499A, LYS499C, LYS94A, LYS94C, MET134A, MET134C, PHE439A, PHE439C, PRO444A, PRO444C, PRO77A, PRO77C, PRO79A, PRO79C, SER132A, SER132C, SER479A, SER479C, SER481A, SER481C, SER498A, SER498C, TRP441A, TRP441C, TRP484A, TRP484C, TYR127A, TYR127C, TYR497A, TYR497C, VAL122A, VAL122C, VAL124A, VAL124C, VAL129A, VAL129C, VAL139A, VAL139C, VAL438A, VAL438C
• A-D: ALA148A, ALA148D, ALA78A, ALA78D, ARG133A, ARG133D, ARG144A, ARG144D, ARG81A, ARG81D, ASN455A, ASN455D, ASP434A, ASP434D, ASP75A, ASP75D, CYS182A, CYS182D, CYS493A, CYS493D, GLN152A, GLN152D, GLU143A, GLU143D, GLU151A, GLU151D, GLY130A, GLY130D, GLY136A, GLY136D, GLY137A, GLY137D, GLY146A, GLY146D, GLY436A, GLY436D, HIS147A, HIS147D, ILE135A, ILE135D, ILE150A, ILE150D, ILE495A, ILE495D, ILE76A, ILE76D, LEU131A, LEU131D, LEU140A, LEU140D, LEU149A, LEU149D, LEU435A, LEU435D, LEU442A, LEU442D, LYS433A, LYS433D, LYS80A, LYS80D, MET134A, MET134D, MET488A, MET488D, PHE439A, PHE439D, PRO138A, PRO138D, PRO141A, PRO141D, PRO145A, PRO145D, PRO77A, PRO77D, PRO79A, PRO79D, SER132A, SER132D, SER142A, SER142D, THR181A, THR181D, THR432A, THR432D, TRP153A, TRP153D, TYR497A, TYR497D, VAL139A, VAL139D, VAL438A, VAL438D, VAL454A, VAL454D
• A-G: ARG440A, LYS508G
• A-H: ALA322H, GLN327H, GLU311A, GLU319H, GLU412A, GLU413A, GLU414A, HIS310A, LYS323H, LYS326H, LYS410A, THR411A
• B-C: ALA148B, ALA148C, ALA78B, ALA78C, ARG133B, ARG133C, ARG144B, ARG144C, ARG437B, ARG437C, ARG81B, ARG81C, ASN455B, ASN455C, ASP434B, ASP434C, ASP75B, ASP75C, CYS182B, CYS182C, CYS493B, CYS493C, GLN152B, GLN152C, GLU143B, GLU143C, GLU151B, GLU151C, GLY130B, GLY130C, GLY136B, GLY136C, GLY137B, GLY137C, GLY146B, GLY146C, GLY436B, GLY436C, HIS147B, HIS147C, ILE135B, ILE135C, ILE150B, ILE150C, ILE495B, ILE495C, ILE76B, ILE76C, LEU131B, LEU131C, LEU140B, LEU140C, LEU149B, LEU149C, LEU435B, LEU435C, LEU442B, LEU442C, LYS433B, LYS433C, LYS80B, LYS80C, MET134B, MET134C, MET488B, MET488C, PHE439B, PHE439C, PRO138B, PRO138C, PRO141B, PRO141C, PRO145B, PRO145C, PRO77B, PRO77C, PRO79B, PRO79C, SER132B, SER132C, SER142B, SER142C, THR181B, THR181C, THR432B, THR432C, TRP153B, TRP153C, TRP484B, TRP484C, TYR497B, TYR497C, VAL139B, VAL139C, VAL438B, VAL438C, VAL454B, VAL454C
• B-D: ALA128B, ALA128D, ALA148B, ALA148D, ARG133B, ARG133D, ARG437B, ARG437D, ARG440B, ARG440D, ARG86B, ARG86D, ARG93B, ARG93D, ASN496B, ASN496D, ASP123B, ASP123D, ASP126B, ASP126D, ASP434B, ASP434D, ASP482B, ASP482D, ASP90B, ASP90D, CYS125B, CYS125D, GLN119B, GLN119D, GLN87B, GLN87D, GLU120B, GLU120D, GLU462B, GLU462D, GLU83B, GLU83D, GLY130B, GLY130D, GLY146B, GLY146D, GLY436B, GLY436D, GLY443B, GLY443D, GLY464B, GLY464D, GLY465B, GLY465D, GLY480B, GLY480D, GLY82B, GLY82D, HIS147B, HIS147D, ILE135B, ILE135D, ILE150B, ILE150D, ILE463B, ILE463D, ILE495B, ILE495D, LEU131B, LEU131D, LEU149B, LEU149D, LEU435B, LEU435D, LEU442B, LEU442D, LYS445D, LYS499B, LYS499D, MET134B, MET134D, PHE439B, PHE439D, PRO444B, PRO444D, PRO77B, PRO77D, PRO79B, PRO79D, SER132B, SER132D, SER479B, SER479D, SER481B, SER481D, SER498B, SER498D, TRP441B, TRP441D, TRP484B, TRP484D, TYR127B, TYR127D, TYR497B, TYR497D, VAL122B, VAL122D, VAL124B, VAL124D, VAL129B, VAL129D, VAL139B, VAL139D, VAL438B, VAL438D
• B-G: ASP75B, LYS508G
• B-H: ALA206B, ARG329H, ARG375H, ASN212B, ASN213B, ASP332H, ASP335H, ASP374H, GLN211B, GLN64B, GLU207B, GLU210B, GLU61B, GLU68B, GLY216B, GLY28B, ILE330H, LEU214B, LYS203B, LYS65B, LYS9H, MET72B, PRO215B, PRO336H, PRO376H, SER29B, SER337H, TRP30B, TRP334H, TYR26B
• C-D: ALA148C, ALA148D, ALA254C, ALA254D, ALA289C, ALA289D, ALA324C, ALA324D, ALA461C, ALA461D, ALA466C, ALA466D, ALA504C, ALA504D, ALA69C, ALA69D, ALA74C, ALA74D, ARG144C, ARG144D, ARG260C, ARG260D, ARG263C, ARG263D, ARG300C, ARG300D, ARG320C, ARG320D, ARG329C, ARG329D, ARG440C, ARG440D, ARG477C, ARG477D, ARG489C, ARG489D, ARG490C, ARG490D, ARG67C, ARG67D, ARG81C, ARG81D, ASN154C, ASN154D, ASN283C, ASN283D, ASN420C, ASN420D, ASN453C, ASN453D, ASN455C, ASN455D, ASN496C, ASN496D, ASP123C, ASP123D, ASP239C, ASP239D, ASP281C, ASP281D, ASP448C, ASP448D, ASP482C, ASP482D, ASP500C, ASP500D, ASP75C, ASP75D, CYS182C, CYS182D, CYS449C, CYS449D, CYS493C, CYS493D, GLN152C, GLN152D, GLN258C, GLN258D, GLN327C, GLN327D, GLN423C, GLN423D, GLN486C, GLN486D, GLN505C, GLN505D, GLU120C, GLU120D, GLU143C, GLU143D, GLU151C, GLU151D, GLU236C, GLU236D, GLU259C, GLU259D, GLU413C, GLU413D, GLU462C, GLU462D, GLU470C, GLU470D, GLU478C, GLU478D, GLU68C, GLY137C, GLY137D, GLY183C, GLY183D, GLY250C, GLY250D, GLY262C, GLY262D, GLY269C, GLY269D, GLY295C, GLY295D, GLY425C, GLY425D, GLY443C, GLY443D, GLY446C, GLY446D, GLY450C, GLY450D, GLY460C, GLY460D, GLY464C, GLY464D, GLY465C, GLY465D, GLY468C, GLY468D, GLY469C, GLY469D, GLY474C, GLY474D, GLY475C, GLY475D, GLY476C, GLY476D, GLY480C, GLY480D, GLY506C, GLY506D, HIS147C, HIS147D, HIS248C, HIS248D, HIS472C, HIS472D, ILE110C, ILE110D, ILE150C, ILE150D, ILE321C, ILE321D, ILE430C, ILE430D, ILE451C, ILE451D, ILE456C, ILE456D, ILE463C, ILE463D, ILE495C, ILE495D, ILE507C, ILE507D, ILE76C, ILE76D, LEU140C, LEU140D, LEU149C, LEU149D, LEU266C, LEU266D, LEU268C, LEU268D, LEU282C, LEU282D, LEU284C, LEU284D, LEU339C, LEU339D, LEU426C, LEU426D, LEU435C, LEU435D, LEU442C, LEU442D, LEU501C, LEU501D, LEU503C, LEU503D, LYS251C, LYS251D, LYS264C, LYS264D, LYS323C, LYS323D, LYS326C, LYS326D, LYS433C, LYS433D, LYS445C, LYS445D, LYS471C, LYS471D, LYS485C, LYS485D, LYS499C, LYS499D, LYS508C, LYS508D, LYS71C, LYS71D, MET252C, MET252D, MET255C, MET255D, MET256C, MET256D, MET488C, MET488D, MET72C, MET72D, PHE261C, PHE261D, PHE291C, PHE291D, PHE431C, PHE431D, PHE439C, PHE439D, PHE467C, PHE467D, PHE509C, PHE509D, PRO138C, PRO138D, PRO141C, PRO141D, PRO155C, PRO155D, PRO287C, PRO287D, PRO444C, PRO444D, PRO457C, PRO457D, PRO502C, PRO502D, PRO77C, PRO77D, SER142C, SER142D, SER246C, SER246D, SER288C, SER288D, SER337C, SER337D, SER427C, SER427D, SER428C, SER428D, SER429C, SER429D, SER447C, SER447D, SER459C, SER459D, SER481C, SER481D, SER483C, SER483D, SER491C, SER491D, SER498C, SER498D, THR247C, THR247D, THR338C, THR338D, THR432C, THR432D, THR473C, THR473D, THR492C, THR492D, THR494C, THR494D, TRP153C, TRP153D, TRP441C, TRP441D, TRP484C, TRP484D, TRP70C, TRP70D, TRP73C, TRP73D, TYR127C, TYR127D, TYR325C, TYR325D, TYR340D, TYR497C, TYR497D, VAL112C, VAL112D, VAL156C, VAL156D, VAL249C, VAL249D, VAL253C, VAL253D, VAL257C, VAL257D, VAL285C, VAL285D, VAL286C, VAL286D, VAL290C, VAL290D, VAL294C, VAL294D, VAL328C, VAL328D, VAL438C, VAL438D, VAL452C, VAL452D, VAL454C, VAL454D
• C-E: ASP75E, LYS508C
• C-F: ARG440F, LYS508C
• C-G: ASP500C, ASP500G, GLY146C, GLY146G, LEU501C, LEU501G, LYS499C, LYS499G, LYS508C, LYS508G, PHE509C, PHE509G, PRO145C, PRO145G, SER498C, SER498G
• C-H: GLN327H, LYS499C
• D-E: ARG329D, ARG375D, ASN212E, ASN213E, ASP332D, ASP335D, ASP374D, GLN211E, GLN327D, GLN64E, GLU210E, GLU61E, GLU68E, GLY216E, GLY28E, GLY331D, LEU214E, LYS14E, LYS203E, LYS326D, LYS65E, LYS71E, LYS9D, MET373D, MET72E, PRO215E, PRO336D, PRO376D, PRO8D, SER29E, SER337D, THR338D, TRP30E
• D-F: ALA316D, ASP315D, GLU319D, GLU412F, GLU413F, LYS323D, LYS326D, LYS410F, THR411F
• D-G: ASN283D, LEU501G, LYS323D, LYS499G
• D-H: ASN283D, ASN283H
• E-F: ALA148E, ALA148F, ALA254E, ALA254F, ALA289E, ALA289F, ALA324E, ALA324F, ALA461E, ALA461F, ALA466E, ALA466F, ALA504E, ALA504F, ALA69F, ALA74E, ALA74F, ARG144E, ARG144F, ARG260E, ARG260F, ARG263E, ARG263F, ARG300E, ARG300F, ARG320E, ARG320F, ARG329E, ARG329F, ARG440E, ARG440F, ARG477E, ARG477F, ARG489E, ARG489F, ARG490E, ARG490F, ARG67E, ARG67F, ARG81E, ARG81F, ASN154E, ASN154F, ASN283E, ASN283F, ASN420E, ASN420F, ASN453E, ASN453F, ASN455E, ASN455F, ASN496E, ASN496F, ASP123E, ASP123F, ASP239E, ASP239F, ASP281E, ASP281F, ASP448E, ASP448F, ASP482E, ASP482F, ASP500E, ASP500F, ASP75E, ASP75F, CYS182E, CYS182F, CYS449E, CYS449F, CYS493E, CYS493F, GLN152E, GLN152F, GLN258E, GLN258F, GLN327E, GLN327F, GLN423E, GLN423F, GLN486E, GLN486F, GLN505E, GLN505F, GLU113E, GLU120E, GLU120F, GLU143E, GLU143F, GLU151E, GLU151F, GLU236E, GLU236F, GLU259E, GLU259F, GLU413E, GLU462E, GLU462F, GLU470E, GLU470F, GLU478E, GLU478F, GLY137E, GLY137F, GLY183E, GLY183F, GLY250E, GLY250F, GLY262E, GLY262F, GLY269E, GLY269F, GLY295E, GLY295F, GLY425E, GLY443E, GLY443F, GLY446E, GLY446F, GLY450E, GLY450F, GLY460E, GLY460F, GLY464E, GLY464F, GLY465E, GLY465F, GLY468E, GLY468F, GLY469E, GLY469F, GLY474E, GLY474F, GLY475E, GLY475F, GLY476E, GLY476F, GLY480E, GLY480F, GLY506E, GLY506F, HIS147E, HIS147F, HIS248E, HIS248F, HIS472E, HIS472F, ILE110E, ILE110F, ILE150E, ILE150F, ILE321E, ILE321F, ILE430E, ILE430F, ILE451E, ILE451F, ILE456E, ILE456F, ILE463E, ILE463F, ILE495E, ILE495F, ILE507E, ILE507F, ILE76E, ILE76F, LEU140E, LEU140F, LEU149E, LEU149F, LEU266E, LEU266F, LEU268E, LEU268F, LEU282E, LEU282F, LEU284E, LEU284F, LEU339E, LEU339F, LEU426E, LEU426F, LEU435E, LEU435F, LEU442E, LEU442F, LEU501E, LEU501F, LEU503E, LEU503F, LYS251E, LYS251F, LYS264E, LYS264F, LYS323E, LYS323F, LYS326E, LYS326F, LYS433E, LYS433F, LYS445E, LYS445F, LYS471E, LYS471F, LYS485E, LYS485F, LYS499E, LYS499F, LYS508E, LYS508F, LYS71E, LYS71F, MET252E, MET252F, MET255E, MET255F, MET256E, MET256F, MET488E, MET488F, MET72E, MET72F, PHE261E, PHE261F, PHE291E, PHE291F, PHE431E, PHE431F, PHE439E, PHE439F, PHE467E, PHE467F, PHE509E, PHE509F, PRO138E, PRO138F, PRO141E, PRO141F, PRO155E, PRO155F, PRO287E, PRO287F, PRO336E, PRO444E, PRO444F, PRO457E, PRO457F, PRO502E, PRO502F, PRO77E, PRO77F, SER142E, SER142F, SER246E, SER246F, SER288E, SER288F, SER337E, SER337F, SER427E, SER427F, SER428E, SER428F, SER429E, SER429F, SER447E, SER447F, SER459E, SER459F, SER481E, SER481F, SER483E, SER483F, SER491E, SER491F, SER498E, SER498F, THR247E, THR247F, THR338E, THR338F, THR432E, THR432F, THR473E, THR473F, THR492E, THR492F, THR494E, THR494F, TRP153E, TRP153F, TRP441E, TRP441F, TRP484E, TRP484F, TRP70E, TRP70F, TRP73E, TRP73F, TYR127E, TYR127F, TYR325E, TYR325F, TYR340E, TYR340F, TYR497E, TYR497F, VAL112E, VAL112F, VAL156E, VAL156F, VAL249E, VAL249F, VAL253E, VAL253F, VAL257E, VAL257F, VAL285E, VAL285F, VAL286E, VAL286F, VAL290E, VAL290F, VAL294E, VAL294F, VAL328E, VAL328F, VAL438E, VAL438F, VAL452E, VAL452F, VAL454E, VAL454F
• E-G: ALA148E, ALA148G, ALA78E, ALA78G, ARG133E, ARG133G, ARG144E, ARG144G, ARG81E, ARG81G, ASN455E, ASN455G, ASP434E, ASP434G, ASP75E, ASP75G, CYS182E, CYS182G, CYS493E, CYS493G, GLN152E, GLN152G, GLU143E, GLU143G, GLU151E, GLU151G, GLY130E, GLY130G, GLY136E, GLY136G, GLY137E, GLY137G, GLY146E, GLY146G, GLY436E, GLY436G, HIS147E, HIS147G, ILE135E, ILE135G, ILE150E, ILE150G, ILE495E, ILE495G, ILE76E, ILE76G, LEU131E, LEU131G, LEU140E, LEU140G, LEU149E, LEU149G, LEU435E, LEU435G, LEU442E, LEU442G, LYS433E, LYS433G, LYS80E, LYS80G, MET134E, MET134G, MET488E, MET488G, PHE439E, PHE439G, PRO138E, PRO138G, PRO141E, PRO141G, PRO145E, PRO145G, PRO77E, PRO77G, PRO79E, PRO79G, SER132E, SER132G, SER142E, SER142G, THR181E, THR181G, THR432E, THR432G, TRP153E, TRP153G, TRP484E, TYR497E, TYR497G, VAL139E, VAL139G, VAL438E, VAL438G, VAL454E, VAL454G
• E-H: ALA128E, ALA128H, ALA148E, ALA148H, ARG133E, ARG133H, ARG437E, ARG437H, ARG440E, ARG440H, ARG86E, ARG86H, ARG93E, ARG93H, ASN496E, ASN496H, ASP123E, ASP123H, ASP126E, ASP126H, ASP434E, ASP434H, ASP482E, ASP482H, ASP90E, ASP90H, CYS125E, CYS125H, GLN119E, GLN119H, GLN87E, GLN87H, GLU120E, GLU120H, GLU412E, GLU412H, GLU462E, GLU462H, GLU83E, GLU83H, GLY130E, GLY130H, GLY146E, GLY146H, GLY436E, GLY436H, GLY443E, GLY443H, GLY464E, GLY464H, GLY465E, GLY465H, GLY480E, GLY480H, GLY82E, GLY82H, HIS147E, HIS147H, ILE135E, ILE135H, ILE150E, ILE150H, ILE463E, ILE463H, ILE495E, ILE495H, LEU131E, LEU131H, LEU149E, LEU149H, LEU435E, LEU435H, LEU442E, LEU442H, LYS445H, LYS499E, LYS499H, LYS94E, LYS94H, MET134E, MET134H, PHE439E, PHE439H, PRO444E, PRO444H, PRO77E, PRO77H, PRO79E, PRO79H, SER132E, SER132H, SER479E, SER479H, SER481E, SER481H, SER498E, SER498H, TRP441E, TRP441H, TRP484E, TRP484H, TYR127E, TYR127H, TYR497E, TYR497H, VAL122E, VAL122H, VAL124E, VAL124H, VAL129E, VAL129H, VAL139E, VAL139H, VAL438E, VAL438H
• F-G: ALA128F, ALA128G, ALA148F, ALA148G, ALA461F, ARG133F, ARG133G, ARG437F, ARG437G, ARG440F, ARG440G, ARG86F, ARG86G, ARG93F, ARG93G, ASN496F, ASN496G, ASP123F, ASP123G, ASP126F, ASP126G, ASP434F, ASP434G, ASP482F, ASP482G, ASP90F, ASP90G, CYS125F, CYS125G, GLN119F, GLN119G, GLN87F, GLN87G, GLU120F, GLU120G, GLU412G, GLU462F, GLU462G, GLU83F, GLU83G, GLY130F, GLY130G, GLY146F, GLY146G, GLY436F, GLY436G, GLY443F, GLY443G, GLY464F, GLY464G, GLY465F, GLY465G, GLY480F, GLY480G, GLY82F, GLY82G, GLY89F, GLY89G, HIS147F, HIS147G, ILE135F, ILE135G, ILE150F, ILE150G, ILE463F, ILE463G, ILE495F, ILE495G, LEU131F, LEU131G, LEU149F, LEU149G, LEU435F, LEU435G, LEU442F, LEU442G, LYS499F, LYS499G, LYS94F, LYS94G, MET134F, MET134G, PHE439F, PHE439G, PRO444F, PRO444G, PRO77F, PRO77G, PRO79F, PRO79G, SER132F, SER132G, SER479F, SER479G, SER481F, SER481G, SER498F, SER498G, TRP441F, TRP441G, TRP484F, TRP484G, TYR127F, TYR127G, TYR497F, TYR497G, VAL122F, VAL122G, VAL124F, VAL124G, VAL129F, VAL129G, VAL139F, VAL139G, VAL438F, VAL438G
• F-H: ALA148F, ALA148H, ALA78F, ALA78H, ARG133F, ARG133H, ARG144F, ARG144H, ARG437F, ARG437H, ARG81F, ARG81H, ASN455F, ASN455H, ASP434F, ASP434H, ASP75F, ASP75H, CYS182F, CYS182H, CYS493F, CYS493H, GLN152F, GLN152H, GLU143F, GLU143H, GLU151F, GLU151H, GLY130F, GLY130H, GLY136F, GLY136H, GLY137F, GLY137H, GLY146F, GLY146H, GLY436F, GLY436H, HIS147F, HIS147H, ILE135F, ILE135H, ILE150F, ILE150H, ILE495F, ILE495H, ILE76F, ILE76H, LEU131F, LEU131H, LEU140F, LEU140H, LEU149F, LEU149H, LEU435F, LEU435H, LEU442F, LEU442H, LYS433F, LYS433H, LYS80F, LYS80H, MET134F, MET134H, MET488F, MET488H, PHE439F, PHE439H, PRO138F, PRO138H, PRO141F, PRO141H, PRO145F, PRO145H, PRO77F, PRO77H, PRO79F, PRO79H, SER132F, SER132H, SER142F, SER142H, THR181F, THR181H, THR432F, THR432H, TRP153F, TRP153H, TYR497F, TYR497H, VAL139F, VAL139H, VAL438F, VAL438H, VAL454F, VAL454H
• G-H: ALA148G, ALA148H, ALA254G, ALA254H, ALA289G, ALA289H, ALA324G, ALA324H, ALA461G, ALA461H, ALA466G, ALA466H, ALA504G, ALA504H, ALA69G, ALA69H, ALA74G, ALA74H, ARG144G, ARG144H, ARG260G, ARG260H, ARG263G, ARG263H, ARG300G, ARG300H, ARG320G, ARG320H, ARG329G, ARG329H, ARG440G, ARG440H, ARG477G, ARG477H, ARG489G, ARG489H, ARG490G, ARG490H, ARG67G, ARG67H, ARG81G, ARG81H, ASN154G, ASN154H, ASN283G, ASN283H, ASN420G, ASN420H, ASN453G, ASN453H, ASN455G, ASN455H, ASN496G, ASN496H, ASP123G, ASP123H, ASP239G, ASP239H, ASP281G, ASP281H, ASP448G, ASP448H, ASP482G, ASP482H, ASP500G, ASP500H, ASP75G, ASP75H, CYS182G, CYS182H, CYS449G, CYS449H, CYS493G, CYS493H, GLN152G, GLN152H, GLN258G, GLN258H, GLN327G, GLN327H, GLN423G, GLN423H, GLN486G, GLN486H, GLN505G, GLN505H, GLU113G, GLU120G, GLU120H, GLU143G, GLU143H, GLU151G, GLU151H, GLU236G, GLU236H, GLU259G, GLU259H, GLU413G, GLU413H, GLU462G, GLU462H, GLU470G, GLU470H, GLU478G, GLU478H, GLY137G, GLY137H, GLY183G, GLY183H, GLY250G, GLY250H, GLY262G, GLY262H, GLY269G, GLY269H, GLY295G, GLY295H, GLY425G, GLY425H, GLY443G, GLY443H, GLY446G, GLY446H, GLY450G, GLY450H, GLY460G, GLY460H, GLY464G, GLY464H, GLY465G, GLY465H, GLY468G, GLY468H, GLY469G, GLY469H, GLY474G, GLY474H, GLY475G, GLY475H, GLY476G, GLY476H, GLY480G, GLY480H, GLY506G, GLY506H, HIS147G, HIS147H, HIS248G, HIS248H, HIS472G, HIS472H, ILE110G, ILE110H, ILE150G, ILE150H, ILE321G, ILE321H, ILE430G, ILE430H, ILE451G, ILE451H, ILE456G, ILE456H, ILE463G, ILE463H, ILE495G, ILE495H, ILE507G, ILE507H, ILE76G, ILE76H, LEU140G, LEU140H, LEU149G, LEU149H, LEU266G, LEU266H, LEU268G, LEU268H, LEU282G, LEU282H, LEU284G, LEU284H, LEU339G, LEU339H, LEU426G, LEU426H, LEU435G, LEU435H, LEU442G, LEU442H, LEU501G, LEU501H, LEU503G, LEU503H, LYS251G, LYS251H, LYS264G, LYS264H, LYS323G, LYS323H, LYS326G, LYS326H, LYS433G, LYS433H, LYS445G, LYS445H, LYS471G, LYS471H, LYS485G, LYS485H, LYS499G, LYS499H, LYS508G, LYS508H, LYS71G, LYS71H, MET252G, MET252H, MET255G, MET255H, MET256G, MET256H, MET488G, MET488H, MET72G, MET72H, PHE261G, PHE261H, PHE291G, PHE291H, PHE431G, PHE431H, PHE439G, PHE439H, PHE467G, PHE467H, PHE509G, PHE509H, PRO138G, PRO138H, PRO141G, PRO141H, PRO155G, PRO155H, PRO287G, PRO287H, PRO336G, PRO444G, PRO444H, PRO457G, PRO457H, PRO502G, PRO502H, PRO77G, PRO77H, SER142G, SER142H, SER246G, SER246H, SER288G, SER288H, SER337G, SER337H, SER427G, SER427H, SER428G, SER428H, SER429G, SER429H, SER447G, SER447H, SER459G, SER459H, SER481G, SER481H, SER483G, SER483H, SER491G, SER491H, SER498G, SER498H, THR247G, THR247H, THR338G, THR432G, THR432H, THR473G, THR473H, THR492G, THR492H, THR494G, THR494H, TRP153G, TRP153H, TRP441G, TRP441H, TRP484G, TRP484H, TRP70G, TRP70H, TRP73G, TRP73H, TYR127G, TYR127H, TYR325G, TYR325H, TYR340G, TYR497G, TYR497H, VAL112G, VAL112H, VAL156G, VAL156H, VAL249G, VAL249H, VAL253G, VAL253H, VAL257G, VAL257H, VAL285G, VAL285H, VAL286G, VAL286H, VAL290G, VAL290H, VAL294G, VAL294H, VAL328G, VAL328H, VAL438G, VAL438H, VAL452G, VAL452H, VAL454G, VAL454H