2JFB

3d structure of lumazine synthase from candida albicans

• Total interactions analyzed: 105
• Total true interactions: 41
• Strongest Interaction:
  • Chains: L-M
  • Int. Res.: 112
  • Norm. En. per Res.: -3.9972
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-36.5993	-28.654	-369.23	-434.4833	116	11	4	13725	6	25	25
A-C	0.0	0.0	-0.0592	-0.0592	6	0	0	21	0	2	8
A-D	0.0	0.0	-0.0991	-0.0991	6	0	0	40	0	2	7
A-E	-27.5479	-19.8172	-371.967	-419.332	117	8	4	13667	6	26	24
A-G	0.0	-7.4028	-1.1478	-8.5506	16	0	0	237	0	5	2
A-H	0.0	-0.7084	-5.644	-6.3524	21	0	0	545	0	11	15
A-N	0.0	0.0	-16.536	-16.536	14	0	0	750	0	6	15
B-C	-28.3083	21.5533	-360.161	-366.916	114	15	4	13604	7	25	25
B-D	0.0	0.0	-0.1117	-0.1117	6	0	0	35	0	2	7
B-E	0.0	0.0	-0.0454	-0.0454	6	0	0	14	0	2	6
B-M	0.0	0.6446	-17.7054	-17.0608	14	0	0	782	0	6	15
C-D	-25.9097	-22.3111	-387.113	-435.3338	118	16	4	14098	5	25	25
C-E	0.0	0.0	-0.0572	-0.0572	6	0	0	24	0	2	6
C-L	0.0	0.6565	-18.8822	-18.2257	18	0	0	836	0	6	15
D-E	-28.2686	-27.0414	-375.954	-431.264	120	16	4	13992	6	25	26
D-K	0.0	0.7922	-22.0908	-21.2986	19	0	0	901	0	6	17
E-G	0.0	0.0	-0.0016	-0.0016	2	0	0	1	0	2	3
E-O	0.0	0.6439	-18.2329	-17.589	16	0	0	776	0	6	17
F-G	-39.3321	-30.227	-369.39	-438.9492	115	16	4	13843	6	26	24
F-H	0.0	0.0	-0.0743	-0.0743	6	0	0	29	0	2	6
F-I	0.0	0.0	-0.0462	-0.0462	6	0	0	22	0	2	7
F-J	-30.1423	-22.3319	-371.961	-424.4352	116	11	4	13679	7	26	24
F-O	0.0	8.0042	-5.7351	2.2691	11	0	0	463	0	8	7
G-H	-22.5795	-22.93	-374.616	-420.1255	116	13	4	13687	6	26	23
G-I	0.0	0.0	-0.0633	-0.0633	6	0	0	24	0	2	6
G-J	0.0	0.0	-0.101	-0.101	6	0	0	35	0	2	8
H-I	-20.7943	-22.8151	-377.18	-420.7893	114	15	4	13951	7	25	27
H-J	0.0	0.0	-0.1183	-0.1183	6	0	0	37	0	2	7
I-J	-22.446	-27.3548	-364.296	-414.0968	113	11	4	13534	6	26	24
I-O	0.0	0.0	-0.6611	-0.6611	6	0	0	65	0	2	1
J-O	-12.0439	13.1969	-64.3476	-63.1946	36	3	0	2790	0	23	19
K-L	-24.1989	-25.4285	-367.609	-417.2364	115	13	4	13726	6	26	24
K-M	0.0	0.0	-0.0863	-0.0863	6	0	0	36	0	2	7
K-N	0.0	0.0	-0.0682	-0.0682	6	0	0	28	0	2	7
K-O	-22.7984	-20.8588	-374.58	-418.2372	116	17	4	13865	5	26	25
L-M	-51.8456	-28.1044	-367.733	-447.6829	112	20	4	13669	6	25	24
L-N	0.0	0.0	-0.0564	-0.0564	6	0	0	21	0	2	7
L-O	0.0	0.0	-0.0432	-0.0432	6	0	0	14	0	2	6
M-N	-27.7369	-23.0167	-377.451	-428.2046	115	13	4	13894	5	26	26
M-O	0.0	0.0	-0.0625	-0.0625	6	0	0	26	0	2	7
N-O	-24.9224	-23.5232	-371.355	-419.8005	117	11	4	13750	6	25	25

Interface residues

• A-B: ALA134B, ALA136B, ALA154B, ALA155B, ALA156B, ALA160B, ALA84B, ARG137B, ARG26A, ARG29A, ARG77A, ASN114B, ASN164B, ASP104A, ASP104B, ASP151B, ASP83B, CYS103A, CYS103B, CYS128B, GLN109A, GLN109B, GLN133B, GLN75A, GLU100A, GLU100B, GLU116A, GLU116B, GLU132B, GLU158B, GLU56A, GLU63A, GLU73A, GLY118B, GLY124B, GLY60A, GLY67A, GLY94A, HIS108A, HIS108B, HIS146B, HIS148B, HIS24A, HIS98A, ILE102A, ILE102B, ILE119B, ILE122B, ILE54A, ILE55A, ILE85A, ILE92B, LEU110A, LEU110B, LEU113A, LEU113B, LEU117A, LEU117B, LEU126B, LEU129B, LEU23A, LEU64A, LEU70A, LEU78A, LEU82A, LEU91B, LYS112A, LYS112B, LYS12B, LYS144B, LYS162B, LYS69A, LYS74A, LYS93A, LYS93B, MET111B, MET145B, MET159B, MET97A, PHE115B, PHE123B, PHE163B, PHE46B, PHE62A, PHE71A, PHE99A, PHE99B, PRO120B, PRO59A, PRO65A, PRO87B, SER105A, SER105B, SER61A, SER68A, SER95A, THR106A, THR106B, THR107A, THR107B, THR127B, THR130B, THR161B, THR57A, THR96A, TRP152B, TRP27A, TYR101A, TYR101B, TYR13B, TYR66A, VAL121B, VAL125B, VAL157B, VAL58A, VAL72A
• A-C: ASP104A, HIS108C, LYS112A, LYS112C, SER105A, TYR101A
• A-D: ASP104D, HIS108A, LYS112A, LYS112D, SER105D, TYR101D
• A-E: ALA134A, ALA136A, ALA154A, ALA155A, ALA156A, ALA160A, ALA84A, ARG137A, ARG26E, ARG29E, ARG77E, ASN114A, ASN164A, ASP104A, ASP104E, ASP151A, ASP83A, CYS103A, CYS103E, CYS128A, GLN109A, GLN109E, GLN133A, GLN75E, GLU100A, GLU100E, GLU116A, GLU116E, GLU132A, GLU158A, GLU56E, GLU63E, GLU73E, GLY118A, GLY124A, GLY60E, GLY67E, GLY94E, HIS108A, HIS108E, HIS146A, HIS148A, HIS24E, HIS98A, HIS98E, ILE102A, ILE102E, ILE119A, ILE122A, ILE54E, ILE55E, ILE85E, ILE92A, LEU110A, LEU110E, LEU113A, LEU113E, LEU117A, LEU117E, LEU126A, LEU129A, LEU23E, LEU64E, LEU70E, LEU78E, LEU91A, LYS112A, LYS112E, LYS12A, LYS144A, LYS162A, LYS69E, LYS74E, LYS93A, LYS93E, MET111A, MET145A, MET159A, MET97A, MET97E, PHE115A, PHE123A, PHE163A, PHE46A, PHE62E, PHE71E, PHE99A, PHE99E, PRO120A, PRO59E, PRO65E, PRO87A, SER105A, SER105E, SER61E, SER68E, SER95E, THR106A, THR106E, THR107A, THR107E, THR127A, THR130A, THR161A, THR57E, THR96E, TRP152A, TRP27E, TYR101A, TYR101E, TYR13A, TYR66E, VAL121A, VAL125A, VAL157A, VAL58E, VAL72E
• A-G: ASP131G, ASP14A, CB9.10930-4.50537, CB9.88918-10.30034, GLU132G, GLU45A, GLY47A, GLY94G, LEU129G, LYS12A, LYS12A5, LYS93G, PHE46A, SER16A, SER95G, THR130G
• A-H: ASP131H, ASP14A, GLN133H, GLN44A, GLU132H, GLU142H, GLU45A, GLU50A, GLY143H, GLY47A, ILE141H, LEU129H, LYS144H, LYS17A, LYS41A, LYS49A, LYS93H, PHE46A, SER16A, THR130H, VAL48A
• A-N: ARG77A, ARG77N, GLN75A, GLN75N, GLY79A, GLY79N, LEU78A, LEU78N, LYS76A, LYS76N, LYS80A, LYS80N, PRO81A, PRO81N
• B-C: ALA134C, ALA136C, ALA154C, ALA155C, ALA156C, ALA160C, ALA84C, ARG137C, ARG26B, ARG29B, ARG77B, ASN114C, ASN164C, ASP104B, ASP104C, ASP151C, ASP83C, CYS103B, CYS103C, CYS128C, GLN109B, GLN109C, GLN133C, GLN75B, GLU100B, GLU100C, GLU116B, GLU116C, GLU132C, GLU158C, GLU56B, GLU63B, GLU73B, GLY118C, GLY124C, GLY60B, GLY67B, GLY94B, HIS108B, HIS108C, HIS146C, HIS148C, HIS24B, HIS98B, ILE102B, ILE102C, ILE119C, ILE122C, ILE54B, ILE55B, ILE85B, LEU110B, LEU110C, LEU113B, LEU113C, LEU117B, LEU117C, LEU126C, LEU129C, LEU23B, LEU64B, LEU70B, LEU78B, LEU82B, LEU91C, LYS112B, LYS112C, LYS12C, LYS144C, LYS162C, LYS69B, LYS74B, LYS93B, LYS93C, MET111C, MET145C, MET159C, MET97B, PHE115C, PHE123C, PHE163C, PHE46C, PHE62B, PHE71B, PHE99B, PHE99C, PRO120C, PRO59B, PRO65B, PRO87C, SER105B, SER105C, SER61B, SER68B, SER95B, THR106B, THR106C, THR107B, THR107C, THR127C, THR130C, THR161C, THR57B, THR96B, TRP152C, TRP27B, TYR101B, TYR101C, TYR13C, TYR66B, VAL121C, VAL125C, VAL58B, VAL72B
• B-D: ASP104B, HIS108D, LYS112B, LYS112D, SER105B, TYR101B
• B-E: ASP104E, HIS108B, LYS112B, LYS112E, SER105E, TYR101E
• B-M: ARG77B, ARG77M, GLN75B, GLN75M, GLY79B, GLY79M, LEU78B, LEU78M, LYS76B, LYS76M, LYS80B, LYS80M, PRO81B, PRO81M
• C-D: ALA134D, ALA136D, ALA154D, ALA155D, ALA156D, ALA160D, ALA25C, ALA84D, ARG137D, ARG26C, ARG77C, ASN114D, ASN164D, ASP104C, ASP104D, ASP151D, ASP83D, CYS103C, CYS103D, CYS128D, GLN109C, GLN109D, GLN133D, GLN75C, GLU100C, GLU100D, GLU116C, GLU116D, GLU132D, GLU150D, GLU158D, GLU56C, GLU63C, GLU73C, GLY118D, GLY124D, GLY60C, GLY67C, GLY94C, HIS108C, HIS108D, HIS146D, HIS148D, HIS24C, HIS98C, HIS98D, ILE102C, ILE102D, ILE119D, ILE122D, ILE54C, ILE55C, ILE85C, ILE92D, LEU110C, LEU110D, LEU113C, LEU113D, LEU117C, LEU117D, LEU126D, LEU129D, LEU23C, LEU64C, LEU70C, LEU78C, LEU91D, LYS112C, LYS112D, LYS12D, LYS144D, LYS162D, LYS69C, LYS74C, LYS93C, LYS93D, MET111D, MET145D, MET159D, MET97C, MET97D, PHE115D, PHE123D, PHE163D, PHE46D, PHE62C, PHE71C, PHE99C, PHE99D, PRO120D, PRO59C, PRO65C, PRO87D, SER105C, SER105D, SER61C, SER68C, SER95C, THR106C, THR106D, THR107C, THR107D, THR127D, THR130D, THR161D, THR57C, THR96C, TRP152D, TRP27C, TYR101C, TYR101D, TYR13D, TYR66C, VAL121D, VAL125D, VAL157D, VAL58C, VAL72C
• C-E: ASP104C, HIS108E, LYS112C, LYS112E, SER105C, TYR101C
• C-L: ARG19C, ARG19L, ARG77C, ARG77L, GLN75C, GLN75L, GLY79C, GLY79L, LEU78C, LEU78L, LYS74C, LYS74L, LYS76C, LYS76L, LYS80C, LYS80L, PRO81C, PRO81L
• D-E: ALA134E, ALA136E, ALA154E, ALA155E, ALA156E, ALA160E, ALA84E, ARG137E, ARG26D, ARG29D, ARG42E, ARG77D, ASN114E, ASN164E, ASP104D, ASP104E, ASP151E, ASP83E, CYS103D, CYS103E, CYS128E, GLN109D, GLN109E, GLN133E, GLN75D, GLU100D, GLU100E, GLU116D, GLU116E, GLU132E, GLU150E, GLU158E, GLU56D, GLU63D, GLU73D, GLY118E, GLY124E, GLY60D, GLY67D, GLY94D, HIS108D, HIS108E, HIS146E, HIS148E, HIS24D, HIS98D, HIS98E, ILE102D, ILE102E, ILE119E, ILE122E, ILE54D, ILE55D, ILE85D, ILE92E, LEU110D, LEU110E, LEU113D, LEU113E, LEU117D, LEU117E, LEU126E, LEU129E, LEU23D, LEU64D, LEU70D, LEU78D, LEU82D, LEU91E, LYS112D, LYS112E, LYS12E, LYS144E, LYS162E, LYS69D, LYS74D, LYS93D, LYS93E, MET111E, MET145E, MET159E, MET97D, MET97E, PHE115E, PHE123E, PHE163E, PHE46E, PHE62D, PHE71D, PHE99D, PHE99E, PRO120E, PRO59D, PRO65D, PRO87E, SER105D, SER105E, SER61D, SER68D, SER95D, THR106D, THR106E, THR107D, THR107E, THR127E, THR130E, THR161E, THR57D, THR96D, TRP152E, TRP27D, TYR101D, TYR101E, TYR13E, TYR66D, VAL121E, VAL125E, VAL157E, VAL58D, VAL72D
• D-K: ARG19D, ARG19K, ARG77D, ARG77K, GLN75D, GLN75K, GLU73D, GLY79D, GLY79K, LEU78D, LEU78K, LYS74D, LYS74K, LYS76D, LYS76K, LYS80D, LYS80K, PRO81D, PRO81K
• E-G: ARG29E, GLU132G
• E-O: ARG19E, ARG19O, ARG77E, ARG77O, GLN75E, GLN75O, GLY79E, GLY79O, LEU78E, LEU78O, LYS76E, LYS76O, LYS80E, LYS80O, PRO81E, PRO81O
• F-G: ALA134G, ALA136G, ALA154G, ALA155G, ALA156G, ALA160G, ALA25F, ALA84G, ARG137G, ARG26F, ARG42G, ARG77F, ASN114G, ASN164G, ASP104F, ASP104G, ASP151G, ASP83G, CYS103F, CYS103G, CYS128G, GLN109F, GLN109G, GLN133G, GLN75F, GLU100F, GLU100G, GLU116F, GLU116G, GLU132G, GLU158G, GLU56F, GLU63F, GLU73F, GLY118G, GLY124G, GLY60F, GLY67F, GLY94F, HIS108F, HIS108G, HIS146G, HIS148G, HIS24F, HIS98F, HIS98G, ILE102F, ILE102G, ILE119G, ILE122G, ILE85F, LEU110F, LEU110G, LEU113F, LEU113G, LEU117F, LEU117G, LEU126G, LEU129G, LEU23F, LEU64F, LEU70F, LEU78F, LEU91G, LYS112F, LYS112G, LYS12G, LYS144G, LYS162G, LYS69F, LYS74F, LYS93F, LYS93G, MET111G, MET145G, MET159G, MET97F, MET97G, PHE115G, PHE123G, PHE163G, PHE46G, PHE62F, PHE71F, PHE99F, PHE99G, PRO120G, PRO59F, PRO65F, PRO87G, SER105F, SER105G, SER61F, SER68F, SER95F, THR106F, THR106G, THR107F, THR107G, THR127G, THR130G, THR161G, THR57F, THR96F, TRP152G, TRP27F, TYR101F, TYR101G, TYR13G, TYR66F, VAL121G, VAL125G, VAL157G, VAL58F, VAL72F
• F-H: ASP104F, HIS108H, LYS112F, LYS112H, SER105F, TYR101F
• F-I: ASP104I, HIS108F, LYS112F, LYS112I, SER105I, TYR101I
• F-J: ALA134F, ALA136F, ALA154F, ALA155F, ALA156F, ALA160F, ALA84F, ARG137F, ARG26J, ARG29J, ARG77J, ASN114F, ASN164F, ASP104F, ASP104J, ASP151F, ASP83F, CYS103F, CYS103J, CYS128F, GLN109F, GLN109J, GLN133F, GLN75J, GLU100F, GLU100J, GLU116F, GLU116J, GLU132F, GLU158F, GLU56J, GLU63J, GLU73J, GLY118F, GLY124F, GLY60J, GLY67J, GLY94J, HIS108F, HIS108J, HIS146F, HIS148F, HIS24J, HIS98J, ILE102F, ILE102J, ILE119F, ILE122F, ILE54J, ILE55J, ILE85J, ILE92F, LEU110F, LEU110J, LEU113F, LEU113J, LEU117F, LEU117J, LEU126F, LEU129F, LEU23J, LEU64J, LEU70J, LEU78J, LEU91F, LYS112F, LYS112J, LYS12F, LYS144F, LYS162F, LYS69J, LYS74J, LYS93F, LYS93J, MET111F, MET145F, MET159F, MET97F, MET97J, PHE115F, PHE123F, PHE163F, PHE46F, PHE62J, PHE71J, PHE99F, PHE99J, PRO120F, PRO59J, PRO65J, PRO87F, SER105F, SER105J, SER61J, SER68J, SER95J, THR106F, THR106J, THR107F, THR107J, THR127F, THR130F, THR161F, THR57J, THR96J, TRP152F, TRP27J, TYR101F, TYR101J, TYR13F, TYR66J, VAL121F, VAL125F, VAL157F, VAL58J, VAL72J
• F-O: ARG137F, GLN133F, GLU132F, GLU50O, GLU51O, LEU129F, LYS144F, LYS49O, LYS80O, MET145F, THR130F
• G-H: ALA134H, ALA136H, ALA154H, ALA155H, ALA156H, ALA160H, ALA25G, ALA84H, ARG137H, ARG26G, ARG42H, ARG77G, ASN114H, ASN164H, ASP104G, ASP104H, ASP151H, ASP83H, CYS103G, CYS103H, CYS128H, GLN109G, GLN109H, GLN133H, GLN75G, GLU100G, GLU100H, GLU116G, GLU116H, GLU132H, GLU158H, GLU56G, GLU63G, GLU73G, GLY118H, GLY124H, GLY60G, GLY67G, GLY94G, HIS108G, HIS108H, HIS146H, HIS148H, HIS24G, HIS98G, ILE102G, ILE102H, ILE119H, ILE122H, ILE54G, ILE55G, ILE85G, ILE92H, LEU110G, LEU110H, LEU113G, LEU113H, LEU117G, LEU117H, LEU126H, LEU129H, LEU23G, LEU64G, LEU70G, LEU78G, LEU82G, LEU91H, LYS112G, LYS112H, LYS144H, LYS162H, LYS69G, LYS74G, LYS93G, LYS93H, MET111H, MET145H, MET159H, MET97G, PHE115H, PHE123H, PHE163H, PHE46H, PHE62G, PHE71G, PHE99G, PHE99H, PRO120H, PRO59G, PRO65G, PRO87H, SER105G, SER105H, SER61G, SER68G, SER95G, THR106G, THR106H, THR107G, THR107H, THR127H, THR130H, THR161H, THR57G, THR96G, TRP152H, TRP27G, TYR101G, TYR101H, TYR13H, TYR66G, VAL121H, VAL125H, VAL157H, VAL58G, VAL72G
• G-I: ASP104G, HIS108I, LYS112G, LYS112I, SER105G, TYR101G
• G-J: ASP104J, HIS108G, LYS112G, LYS112J, SER105J, TYR101J
• H-I: ALA134I, ALA136I, ALA154I, ALA155I, ALA156I, ALA160I, ALA84I, ARG137I, ARG26H, ARG77H, ASN114I, ASN164I, ASP104H, ASP104I, ASP151I, ASP83I, CYS103H, CYS103I, CYS128I, GLN109H, GLN109I, GLN133I, GLN75H, GLU100H, GLU100I, GLU116H, GLU116I, GLU132I, GLU158I, GLU56H, GLU63H, GLU73H, GLY118I, GLY124I, GLY60H, GLY67H, GLY94H, HIS108H, HIS108I, HIS146I, HIS148I, HIS24H, HIS98H, ILE102H, ILE102I, ILE119I, ILE122I, ILE54H, ILE55H, ILE85H, ILE92I, LEU110H, LEU110I, LEU113H, LEU113I, LEU117H, LEU117I, LEU126I, LEU129I, LEU23H, LEU64H, LEU70H, LEU78H, LEU82H, LEU91I, LYS112H, LYS112I, LYS12I, LYS162I, LYS69H, LYS74H, LYS93H, LYS93I, MET111I, MET145I, MET159I, MET97H, PHE115I, PHE123I, PHE163I, PHE46I, PHE62H, PHE71H, PHE99H, PHE99I, PRO120I, PRO59H, PRO65H, PRO87I, SER105H, SER105I, SER61H, SER68H, SER95H, THR106H, THR106I, THR107H, THR107I, THR127I, THR130I, THR161I, THR57H, THR96H, TRP152I, TRP27H, TYR101H, TYR101I, TYR13I, TYR66H, VAL121I, VAL125I, VAL157I, VAL58H, VAL72H
• H-J: ASP104H, HIS108J, LYS112H, LYS112J, SER105H, TYR101H
• I-J: ALA134J, ALA136J, ALA154J, ALA155J, ALA156J, ALA160J, ALA84J, ARG137J, ARG26I, ARG77I, ASN114J, ASN164J, ASP104I, ASP104J, ASP151J, ASP83J, CYS103I, CYS103J, CYS128J, GLN109I, GLN109J, GLN133J, GLN75I, GLU100I, GLU100J, GLU116I, GLU116J, GLU132J, GLU158J, GLU56I, GLU63I, GLU73I, GLY118J, GLY124J, GLY60I, GLY67I, GLY94I, HIS108I, HIS108J, HIS146J, HIS148J, HIS24I, HIS98I, ILE102I, ILE102J, ILE119J, ILE122J, ILE54I, ILE55I, ILE85I, ILE92J, LEU110I, LEU110J, LEU113I, LEU113J, LEU117I, LEU117J, LEU126J, LEU129J, LEU23I, LEU64I, LEU70I, LEU78I, LEU91J, LYS112I, LYS112J, LYS144J, LYS162J, LYS69I, LYS74I, LYS93I, LYS93J, MET111J, MET145J, MET159J, MET97I, PHE115J, PHE123J, PHE163J, PHE46J, PHE62I, PHE71I, PHE99I, PHE99J, PRO120J, PRO59I, PRO65I, PRO87J, SER105I, SER105J, SER61I, SER68I, SER95I, THR106I, THR106J, THR107I, THR107J, THR127J, THR130J, THR161J, THR57I, THR96I, TRP152J, TRP27I, TYR101I, TYR101J, TYR13J, TYR66I, VAL121J, VAL125J, VAL157J, VAL58I, VAL72I
• I-O: ASP14O, LYS12O, MET97I, SER16O, SER95I, TYR13O
• J-O: ALA134J, ARG137J, ARG42O, ASN52O, ASP131J, ASP14O, GLN133J, GLN44O, GLU132J, GLU135J, GLU45O, GLU50O, GLU51O, GLY15O, GLY47O, GLY94J, ILE141J, ILE31J, ILE92J, LEU129J, LEU43O, LYS12O, LYS144J, LYS30J, LYS41O, LYS49O, LYS93J, MET97J, PHE46O, SER16O, SER95J, THR130J, THR96J, TYR13O, VAL157O, VAL48O
• K-L: ALA134L, ALA136L, ALA154L, ALA155L, ALA156L, ALA160L, ALA84L, ARG137L, ARG26K, ARG77K, ASN114L, ASN164L, ASP104K, ASP104L, ASP151L, ASP83L, CYS103K, CYS103L, CYS128L, GLN109K, GLN109L, GLN133L, GLN75K, GLU100K, GLU100L, GLU116K, GLU116L, GLU132L, GLU158L, GLU56K, GLU63K, GLU73K, GLY118L, GLY124L, GLY60K, GLY67K, GLY94K, HIS108K, HIS108L, HIS146L, HIS148L, HIS24K, HIS98K, ILE102K, ILE102L, ILE119L, ILE122L, ILE54K, ILE55K, ILE85K, ILE92L, LEU110K, LEU110L, LEU113K, LEU113L, LEU117K, LEU117L, LEU126L, LEU129L, LEU23K, LEU64K, LEU70K, LEU78K, LEU82K, LEU91L, LYS112K, LYS112L, LYS144L, LYS162L, LYS69K, LYS74K, LYS93K, LYS93L, MET111L, MET145L, MET159L, MET97K, MET97L, PHE115L, PHE123L, PHE163L, PHE46L, PHE62K, PHE71K, PHE99K, PHE99L, PRO120L, PRO59K, PRO65K, PRO87L, SER105K, SER105L, SER61K, SER68K, SER95K, THR106K, THR106L, THR107K, THR107L, THR127L, THR130L, THR161L, THR57K, THR96K, TRP152L, TRP27K, TYR101K, TYR101L, TYR13L, TYR66K, VAL121L, VAL125L, VAL157L, VAL58K, VAL72K
• K-M: ASP104K, HIS108M, LYS112K, LYS112M, SER105K, TYR101K
• K-N: ASP104N, HIS108K, LYS112K, LYS112N, SER105N, TYR101N
• K-O: ALA134K, ALA136K, ALA154K, ALA155K, ALA156K, ALA160K, ALA25O, ALA84K, ARG137K, ARG26O, ARG77O, ASN114K, ASN164K, ASP104K, ASP104O, ASP151K, ASP83K, CYS103K, CYS103O, CYS128K, GLN109K, GLN109O, GLN133K, GLN75O, GLU100K, GLU100O, GLU116K, GLU116O, GLU132K, GLU158K, GLU56O, GLU63O, GLU73O, GLY118K, GLY124K, GLY60O, GLY67O, GLY94O, HIS108K, HIS108O, HIS146K, HIS148K, HIS24O, HIS98K, HIS98O, ILE102K, ILE102O, ILE119K, ILE122K, ILE54O, ILE55O, ILE85O, ILE92K, LEU110K, LEU110O, LEU113K, LEU113O, LEU117K, LEU117O, LEU126K, LEU129K, LEU23O, LEU64O, LEU70O, LEU78O, LEU82O, LEU91K, LYS112K, LYS112O, LYS162K, LYS69O, LYS74O, LYS93K, LYS93O, MET111K, MET145K, MET159K, MET97K, MET97O, PHE115K, PHE123K, PHE163K, PHE46K, PHE62O, PHE71O, PHE99K, PHE99O, PRO120K, PRO59O, PRO65O, PRO87K, SER105K, SER105O, SER61O, SER68O, SER95O, THR106K, THR106O, THR107K, THR107O, THR127K, THR130K, THR161K, THR57O, THR96O, TRP152K, TRP27O, TYR101K, TYR101O, TYR13K, TYR66O, VAL121K, VAL125K, VAL157K, VAL58O, VAL72O
• L-M: ALA134M, ALA136M, ALA154M, ALA155M, ALA156M, ALA160M, ALA84M, ARG137M, ARG26L, ARG77L, ASN114M, ASN164M, ASP104L, ASP104M, ASP151M, ASP83M, CYS103L, CYS103M, CYS128M, GLN109L, GLN109M, GLN133M, GLN75L, GLU100L, GLU100M, GLU116L, GLU116M, GLU132M, GLU158M, GLU56L, GLU63L, GLU73L, GLY118M, GLY124M, GLY60L, GLY67L, GLY94L, HIS108L, HIS108M, HIS146M, HIS148M, HIS24L, HIS98L, ILE102L, ILE102M, ILE119M, ILE122M, ILE54L, ILE55L, ILE85L, LEU110L, LEU110M, LEU113L, LEU113M, LEU117L, LEU117M, LEU126M, LEU129M, LEU23L, LEU64L, LEU70L, LEU78L, LEU91M, LYS112L, LYS112M, LYS144M, LYS162M, LYS69L, LYS74L, LYS93L, LYS93M, MET111M, MET145M, MET159M, MET97L, PHE115M, PHE123M, PHE163M, PHE46M, PHE62L, PHE71L, PHE99L, PHE99M, PRO120M, PRO59L, PRO65L, PRO87M, SER105L, SER105M, SER61L, SER68L, SER95L, THR106L, THR106M, THR107L, THR107M, THR127M, THR130M, THR161M, THR57L, THR96L, TRP152M, TRP27L, TYR101L, TYR101M, TYR13M, TYR66L, VAL121M, VAL125M, VAL157M, VAL58L, VAL72L
• L-N: ASP104L, HIS108N, LYS112L, LYS112N, SER105L, TYR101L
• L-O: ASP104O, HIS108L, LYS112L, LYS112O, SER105O, TYR101O
• M-N: ALA134N, ALA136N, ALA154N, ALA155N, ALA156N, ALA160N, ALA84N, ARG137N, ARG26M, ARG29M, ARG77M, ASN114N, ASN164N, ASP104M, ASP104N, ASP151N, ASP83N, CYS103M, CYS103N, CYS128N, GLN109M, GLN109N, GLN133N, GLN75M, GLU100M, GLU100N, GLU116M, GLU116N, GLU132N, GLU158N, GLU56M, GLU63M, GLU73M, GLY118N, GLY124N, GLY60M, GLY67M, GLY94M, HIS108M, HIS108N, HIS146N, HIS148N, HIS24M, HIS98M, ILE102M, ILE102N, ILE119N, ILE122N, ILE54M, ILE55M, ILE85M, LEU110M, LEU110N, LEU113M, LEU113N, LEU117M, LEU117N, LEU126N, LEU129N, LEU23M, LEU64M, LEU70M, LEU78M, LEU82M, LEU91N, LYS112M, LYS112N, LYS12N, LYS144N, LYS162N, LYS69M, LYS74M, LYS93M, LYS93N, MET111N, MET145N, MET159N, MET97M, PHE115N, PHE123N, PHE163N, PHE46N, PHE62M, PHE71M, PHE99M, PHE99N, PRO120N, PRO59M, PRO65M, PRO87N, SER105M, SER105N, SER61M, SER68M, SER95M, THR106M, THR106N, THR107M, THR107N, THR127N, THR130N, THR161N, THR57M, THR96M, TRP152N, TRP27M, TYR101M, TYR101N, TYR13N, TYR66M, VAL121N, VAL125N, VAL157N, VAL58M, VAL72M
• M-O: ASP104M, HIS108O, LYS112M, LYS112O, SER105M, TYR101M
• N-O: ALA134O, ALA136O, ALA154O, ALA155O, ALA156O, ALA160O, ALA84O, ARG137O, ARG26N, ARG29N, ARG77N, ASN114O, ASN164O, ASP104N, ASP104O, ASP151O, ASP83O, CYS103N, CYS103O, CYS128O, GLN109N, GLN109O, GLN133O, GLN75N, GLU100N, GLU100O, GLU116N, GLU116O, GLU132O, GLU158O, GLU56N, GLU63N, GLU73N, GLY118O, GLY124O, GLY60N, GLY67N, GLY94N, HIS108N, HIS108O, HIS146O, HIS148O, HIS24N, HIS98N, ILE102N, ILE102O, ILE119O, ILE122O, ILE54N, ILE55N, ILE85N, ILE92O, LEU110N, LEU110O, LEU113N, LEU113O, LEU117N, LEU117O, LEU126O, LEU129O, LEU23N, LEU64N, LEU70N, LEU78N, LEU82N, LEU91O, LYS112N, LYS112O, LYS12O, LYS144O, LYS162O, LYS69N, LYS74N, LYS93N, LYS93O, MET111O, MET145O, MET159O, MET97N, MET97O, PHE115O, PHE123O, PHE163O, PHE46O, PHE62N, PHE71N, PHE99N, PHE99O, PRO120O, PRO59N, PRO65N, PRO87O, SER105N, SER105O, SER61N, SER68N, SER95N, THR106N, THR106O, THR107N, THR107O, THR127O, THR130O, THR161O, THR57N, THR96N, TRP152O, TRP27N, TYR101N, TYR101O, TYR13O, TYR66N, VAL121O, VAL125O, VAL157O, VAL58N, VAL72N