2JD6

crystal structure of the as isolated ferritin from the hyperthermophilic archaeal anaerobe pyrococcus furiosus

• Total interactions analyzed: 630
• Total true interactions: 105
• Strongest Interaction:
  • Chains: E-W
  • Int. Res.: 129
  • Norm. En. per Res.: -5.0577
• Hub Node: 3(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
0-2	0.0	0.0	-0.9422	-0.9422	7	0	0	127	0	0	0
0-7	0.0	-16.6757	-104.011	-120.6867	53	0	4	4592	0	21	25
0-G	0.0	-17.3706	-68.969	-86.3396	40	0	1	3026	2	17	11
0-H	0.0	-19.0607	-63.9193	-82.98	38	2	1	2948	1	16	12
0-I	-111.9039	-82.2566	-441.671	-635.8315	127	21	15	16288	5	33	33
0-Z	0.0	-10.4353	-100.92	-111.3553	53	4	4	4529	0	22	26
1-5	0.0	-6.6052	-102.704	-109.3092	53	2	4	4630	1	21	26
1-6	0.0	-8.1049	-106.871	-114.9759	53	0	4	4643	1	22	27
1-7	0.0	0.0	-0.6424	-0.6424	7	0	0	103	0	0	0
1-I	-8.3914	-29.5582	-63.5619	-101.5115	39	3	1	3068	2	16	11
1-J	-97.8063	-59.3921	-439.768	-596.9664	127	28	15	16363	6	35	33
1-O	-7.5851	-23.1646	-69.9599	-100.7096	42	4	1	3041	2	17	11
2-3	0.0	-17.1276	-112.606	-129.7337	52	2	4	4745	1	21	26
2-D	0.0	0.0	-0.0227	-0.0227	2	0	0	6	0	1	1
2-G	-4.004	-18.2565	-64.3525	-86.613	39	1	1	2910	2	16	11
2-H	0.0	-8.2591	-56.1219	-64.381	37	1	1	2881	0	16	11
2-K	-71.0973	-69.6161	-447.836	-588.5494	128	21	14	16522	6	36	36
2-Y	-8.9922	-9.0767	-93.4165	-111.4854	52	9	4	4701	1	21	26
3-9	0.0	0.0	-0.5698	-0.5698	7	0	0	88	0	0	0
3-C	0.0	0.0	-0.0845	-0.0845	4	0	0	37	0	0	2
3-D	-25.848	33.9406	-69.1433	-61.0507	32	5	0	2640	1	27	33
3-K	0.0	-14.3211	-62.8065	-77.1276	38	1	1	2883	0	16	11
3-L	-61.2532	-65.8431	-437.575	-564.6713	129	13	13	16288	5	33	32
3-Q	-2.5238	-21.5719	-72.0461	-96.1417	42	1	1	3084	2	17	11
3-Y	0.0	-18.2566	-101.942	-120.1986	50	8	4	4848	1	22	26
4-8	0.0	1.8576	-97.3026	-95.445	52	1	4	4427	1	21	25
4-9	0.0	-15.1565	-102.18	-117.3365	54	7	4	4512	1	22	24
4-M	-82.4843	-68.6371	-445.48	-596.6014	127	23	14	16471	6	34	34
4-P	0.0	-14.0615	-61.9748	-76.0363	36	1	1	2927	1	16	11
4-R	-5.4258	-22.2742	-65.7568	-93.4568	39	7	1	2998	1	17	11
4-Z	0.0	0.0	-0.4042	-0.4042	7	0	0	96	0	0	0
5-6	0.0	8.2359	-105.863	-97.6271	53	2	5	4648	1	22	26
5-J	0.0	-20.4753	-69.6444	-90.1197	37	3	1	2947	2	17	12
5-L	-3.9054	-18.9453	-64.6463	-87.497	36	1	1	2848	2	16	10
5-N	-86.9526	-78.6149	-419.862	-585.4294	129	20	14	16483	7	34	35
5-Y	0.0	0.0	-1.8816	-1.8816	11	0	0	163	0	0	0
6-8	0.0	0.0	-0.4102	-0.4102	7	0	0	88	0	0	0
6-M	-8.3744	-12.6955	-61.9616	-83.0315	40	1	1	3077	1	16	11
6-N	0.0	-9.2288	-62.0376	-71.2664	37	1	1	2923	0	16	12
6-O	-99.374	-81.7334	-440.704	-621.8114	129	21	15	16573	6	35	35
7-I	0.0	-16.9885	-71.9692	-88.9577	37	2	1	3003	2	16	10
7-O	-7.991	-18.1064	-61.1144	-87.2118	37	0	1	2931	1	16	10
7-P	-87.2624	-67.0425	-423.896	-578.2009	129	27	14	16144	5	34	34
7-Z	0.0	3.0408	-104.406	-101.3652	52	3	4	4571	0	22	27
8-9	0.0	-19.6822	-108.762	-128.4442	52	2	4	4846	1	21	26
8-M	0.0	-23.6515	-65.1542	-88.8057	41	2	1	3208	2	17	12
8-N	-4.5759	-19.4337	-68.7399	-92.7495	36	0	1	2969	2	16	11
8-Q	-82.474	-73.8165	-448.696	-604.9865	129	20	14	16432	6	35	34
9-K	-8.1382	-20.8551	-64.8316	-93.8249	38	0	1	2819	2	16	11
9-Q	0.0	-14.1513	-62.9219	-77.0732	36	1	1	3035	1	16	11
9-R	-87.1622	-80.5242	-435.866	-603.5524	129	23	14	16274	6	33	32
A-B	0.0	0.0	-0.5698	-0.5698	5	0	0	80	0	0	0
A-C	-3.737	-14.1598	-105.365	-123.2617	53	0	4	4547	1	21	25
A-D	-3.5734	-7.429	-108.814	-119.8164	52	0	4	4632	1	22	26
A-S	-120.4123	-79.189	-442.527	-642.1283	129	20	14	16378	5	35	34
A-U	-4.4543	-19.6395	-71.035	-95.1288	40	2	1	2941	2	16	11
A-W	-5.6706	-17.8341	-65.0017	-88.5064	38	2	1	2838	2	16	12
B-E	-6.57	-9.707	-105.859	-122.136	51	1	4	4572	1	22	27
B-T	-99.1291	-70.6253	-433.073	-602.8274	129	25	14	16315	6	35	36
B-U	0.0	-22.1401	-72.2514	-94.3915	42	1	1	3093	2	17	12
B-W	-6.784	-19.0315	-61.8249	-87.6404	39	2	1	2869	2	16	10
C-D	0.0	-12.2448	-103.408	-115.6528	53	4	4	4714	1	23	25
C-G	0.0	15.7178	-4.3572	11.3606	13	0	0	258	0	13	10
C-U	-93.5576	-67.6959	-436.64	-597.8935	128	17	14	16580	6	33	34
C-V	-3.5363	-18.728	-73.7942	-96.0585	40	2	1	3085	1	16	11
C-Y	-23.8909	-51.0347	-242.251	-317.1766	109	9	4	9448	9	89	86
D-F	0.0	0.0	-0.6506	-0.6506	9	0	0	134	0	0	0
D-S	0.0	-15.1507	-68.6966	-83.8473	39	2	1	3037	2	16	11
D-V	-79.6692	-83.6853	-436.763	-600.1175	132	14	14	16423	6	36	36
D-Y	0.0	3.0387	-8.5698	-5.5311	15	0	0	609	0	12	7
E-W	-123.4622	-82.1628	-446.824	-652.449	129	18	14	16395	6	34	36
E-X	-3.8445	-16.8516	-70.9416	-91.6378	41	7	1	3246	1	16	11
F-S	-24.3668	-22.893	-70.9629	-118.2227	39	4	1	3028	2	16	11
F-X	-90.5889	-75.7518	-435.844	-602.1847	129	21	14	16352	6	36	36
G-H	0.0	0.0	-0.1547	-0.1547	9	0	0	46	0	0	0
G-I	-7.8869	-13.406	-107.948	-129.2409	53	1	4	4615	1	22	25
G-J	0.0	-13.9686	-105.315	-119.2836	52	2	4	4611	1	22	27
G-U	0.0	1.258	-0.1702	1.0878	6	0	0	68	0	3	4
G-Y	-82.5436	-79.9397	-441.457	-603.9403	128	16	14	16303	7	33	35
H-K	-7.87	-5.3494	-105.429	-118.6484	54	5	4	4603	1	22	26
H-R	0.0	-4.02	-102.929	-106.949	51	3	4	4654	1	22	26
H-Z	-81.3698	-74.7787	-452.135	-608.2835	127	16	14	16509	7	37	33
I-J	0.0	-15.2029	-109.27	-124.4729	52	3	4	4809	1	22	26
I-O	0.0	0.0	-0.3741	-0.3741	6	0	0	86	0	0	0
J-L	0.0	0.0	-1.0664	-1.0664	8	0	0	98	0	0	0
J-Y	-7.2376	-22.094	-67.8475	-97.1791	39	2	1	2998	2	16	11
K-Q	0.0	0.0	-0.4702	-0.4702	7	0	0	70	0	0	0
K-R	-5.8709	-7.4156	-106.038	-119.3245	53	1	4	4618	1	22	26
L-N	0.0	-14.8769	-104.71	-119.5869	52	7	4	4710	1	22	26
L-Q	0.0	-7.5898	-112.481	-120.0708	54	3	4	4778	1	22	26
L-Y	0.0	-18.1365	-64.2974	-82.4339	39	4	1	2912	0	16	11
M-N	0.0	0.0	-0.3454	-0.3454	7	0	0	73	0	0	0
M-O	0.0	-10.126	-106.914	-117.04	53	1	4	4754	1	21	27
M-P	0.0	-8.5024	-109.635	-118.1374	55	5	4	4736	1	22	26
N-Q	0.0	-5.8948	-102.747	-108.6418	53	1	4	4570	1	22	27
O-P	-7.6656	-9.2845	-101.14	-118.0901	51	1	4	4485	1	21	25
P-R	0.0	0.0	-4.4868	-4.4868	11	0	0	230	0	0	0
P-Z	-2.9336	-15.4842	-58.1649	-76.5827	38	3	1	2945	1	16	11
R-Z	-3.3073	-19.2438	-74.1095	-96.6605	40	1	1	3127	2	16	11
S-W	0.0	-14.8189	-98.7165	-113.5354	50	2	4	4517	1	21	25
S-X	0.0	-14.7602	-103.8	-118.5602	51	2	4	4609	1	21	25
T-U	0.0	-6.9995	-109.693	-116.6925	54	1	4	4636	1	22	26
U-W	0.0	0.0	-0.6578	-0.6578	9	0	0	110	0	0	0
U-Y	0.0	0.0	-0.0166	-0.0166	3	0	0	6	0	6	2
W-X	-6.45	-10.7092	-110.705	-127.8643	54	1	4	4878	1	22	26

Interface residues

• 0-2: GLN1490, GLN1492, ILE1500, MET1530, MET1532, PHE1520, SER1470
• 0-7: ALA1057, ALA1067, ALA1087, ALA1180, ALA1327, ARG1170, ARG1177, ARG640, ASN1257, ASN590, ASN650, ASP1130, ASP1397, ASP630, GLN1277, GLU1037, GLU1090, GLU1097, GLU1107, GLU1210, GLU1217, GLU1267, GLU1297, GLU1307, GLU1317, GLU947, ILE1017, ILE1247, LEU1047, LEU1077, LEU1200, LEU1207, LEU1387, LYS1120, LYS1357, LYS1367, LYS957, LYS997, MET10, PHE1190, SER1150, SER1337, SER987, THR1160, TRP1220, TRP1227, TYR1027, TYR1140, TYR600, TYR620, TYR917, VAL1287, VAL1347
• 0-G: ALA144G, ASN410, ASP139G, ASP146G, ASP1550, ASP155G, ASP330, GLN1490, GLN149G, GLU157G, GLU320, GLU370, GLY350, GLY380, ILE1500, ILE150G, LEU1510, LEU151G, LEU1540, LEU154G, LEU158G, LEU340, LEU360, LYS135G, LYS136G, LYS140G, LYS145G, LYS1560, LYS156G, MET1530, MET153G, PHE143G, PHE1520, PHE152G, PHE390, PRO1480, PRO148G, PRO830, SER1470, SER147G
• 0-H: ALA1440, ASP1390, ASP1460, ASP1550, ASP155H, ASP33H, GLN1490, GLN149H, GLU1570, GLU32H, GLU37H, GLY35H, GLY38H, ILE1500, ILE150H, LEU1410, LEU1510, LEU151H, LEU1540, LEU154H, LEU1580, LEU34H, LEU36H, LYS1360, LYS1400, LYS1450, LYS1560, LYS156H, MET1530, MET153H, PHE1430, PHE1520, PHE152H, PRO1480, PRO148H, PRO83H, SER1470, SER147H
• 0-I: ALA210, ALA21I, ALA260, ALA26I, ALA280, ALA28I, ALA290, ALA29I, ALA400, ALA40I, ALA450, ALA45I, ALA470, ALA47I, ALA540, ALA54I, ARG16I, ARG560, ARG56I, ARG670, ARG67I, ASN110, ASN11I, ASN150, ASN15I, ASN410, ASN41I, ASN590, ASN59I, ASN650, ASN65I, ASP330, ASP33I, ASP630, ASP63I, ASP710, ASP71I, GLU320, GLU32I, GLU370, GLU37I, GLU480, GLU48I, GLU490, GLU49I, GLU500, GLU50I, GLU690, GLU69I, GLU720, GLU72I, GLU790, GLU79I, GLY1670, GLY167I, GLY350, GLY35I, GLY520, GLY52I, GLY660, GLY66I, HIS530, ILE510, ILE51I, ILE610, ILE61I, ILE730, ILE73I, LEU140, LEU14I, LEU1650, LEU165I, LEU180, LEU18I, LEU230, LEU23I, LEU340, LEU34I, LEU550, LEU55I, LEU70, LEU700, LEU70I, LEU7I, LYS1640, LYS164I, LYS440, LYS44I, LYS750, LYS75I, LYS780, LYS78I, MET270, MET27I, MET430, MET43I, PHE250, PHE25I, PHE310, PHE31I, PHE570, PRO1630, PRO163I, PRO1660, PRO166I, PRO740, PRO74I, PRO760, PRO76I, PRO770, PRO77I, TRP800, TRP80I, TYR190, TYR19I, TYR220, TYR22I, TYR240, TYR24I, TYR300, TYR30I, TYR580, TYR58I, TYR620, TYR62I, VAL680, VAL68I
• 0-Z: ALA1050, ALA1060, ALA1080, ALA118Z, ALA1320, ARG1170, ARG117Z, ARG64Z, ASN1250, ASN59Z, ASN65Z, ASP113Z, ASP1390, ASP63Z, GLN1270, GLU1030, GLU1090, GLU109Z, GLU1100, GLU1210, GLU121Z, GLU1260, GLU1290, GLU1300, GLU1310, GLU940, ILE1010, ILE1240, LEU1040, LEU1070, LEU1200, LEU120Z, LEU1380, LYS112Z, LYS1350, LYS1360, LYS950, LYS990, MET1Z, PHE119Z, PHE1230, SER115Z, SER1330, SER980, THR116Z, TRP1220, TRP122Z, TYR1020, TYR114Z, TYR60Z, TYR62Z, TYR910, VAL1280
• 1-5: ALA1055, ALA1065, ALA1085, ALA1181, ALA1325, ARG1171, ARG1175, ARG641, ASN1255, ASN591, ASN651, ASP1131, ASP1395, ASP631, GLN1275, GLU1035, GLU1091, GLU1095, GLU1105, GLU1211, GLU1215, GLU1265, GLU1295, GLU1305, GLU1315, ILE1015, ILE1245, LEU1045, LEU1075, LEU1201, LEU1205, LEU1385, LYS1121, LYS1355, LYS1365, LYS1425, LYS955, LYS995, MET11, PHE1191, PHE1235, SER1151, SER1335, SER985, THR1161, TRP1221, TRP1225, TYR1025, TYR1141, TYR601, TYR621, TYR915, VAL1285
• 1-6: ALA1051, ALA1061, ALA1081, ALA1186, ALA1321, ARG1171, ARG1176, ARG646, ASN1251, ASN596, ASN656, ASP1136, ASP1391, ASP636, GLN1271, GLU1031, GLU1091, GLU1096, GLU1101, GLU1211, GLU1216, GLU1261, GLU1291, GLU1301, GLU1311, ILE1011, ILE1241, LEU1041, LEU1071, LEU1201, LEU1206, LEU1381, LEU26, LYS1126, LYS1351, LYS1361, LYS951, LYS991, MET16, PHE1196, PHE1231, SER1156, SER1331, SER981, THR1166, TRP1221, TRP1226, TYR1021, TYR1146, TYR606, TYR626, TYR911, VAL1281
• 1-7: GLN1491, GLN1497, ILE1501, ILE1507, MET1531, MET1537, SER1477
• 1-I: ALA144I, ASN411, ASP139I, ASP146I, ASP1551, ASP155I, ASP331, GLN1491, GLN149I, GLU157I, GLU321, GLU371, GLY351, GLY381, ILE137I, ILE1501, ILE150I, LEU141I, LEU1511, LEU151I, LEU154I, LEU341, LEU361, LYS135I, LYS136I, LYS140I, LYS142I, LYS145I, LYS1561, LYS156I, MET1531, MET153I, PHE143I, PHE1521, PRO1481, PRO148I, PRO831, SER1471, SER147I
• 1-J: ALA211, ALA21J, ALA261, ALA26J, ALA281, ALA28J, ALA291, ALA29J, ALA401, ALA40J, ALA451, ALA45J, ALA471, ALA47J, ALA541, ALA54J, ARG561, ARG56J, ARG671, ARG67J, ASN111, ASN11J, ASN151, ASN15J, ASN411, ASN41J, ASN591, ASN59J, ASN651, ASN65J, ASP331, ASP33J, ASP63J, ASP711, ASP71J, GLU321, GLU32J, GLU371, GLU37J, GLU481, GLU48J, GLU491, GLU49J, GLU501, GLU691, GLU69J, GLU721, GLU72J, GLU791, GLU79J, GLY1671, GLY167J, GLY351, GLY35J, GLY521, GLY52J, GLY661, GLY66J, HIS531, ILE511, ILE51J, ILE611, ILE61J, ILE731, ILE73J, LEU141, LEU14J, LEU1651, LEU165J, LEU181, LEU18J, LEU231, LEU23J, LEU341, LEU34J, LEU551, LEU55J, LEU701, LEU70J, LEU71, LEU7J, LYS1641, LYS164J, LYS441, LYS44J, LYS751, LYS75J, LYS781, LYS78J, LYS81, LYS8J, MET271, MET27J, MET431, MET43J, PHE251, PHE25J, PHE311, PHE31J, PHE571, PHE57J, PRO1631, PRO163J, PRO1661, PRO166J, PRO741, PRO74J, PRO761, PRO76J, PRO771, PRO77J, TRP801, TRP80J, TYR191, TYR19J, TYR221, TYR22J, TYR241, TYR24J, TYR301, TYR30J, TYR581, TYR58J, TYR621, TYR62J, VAL681, VAL68J
• 1-O: ALA1441, ASN41O, ASP1391, ASP1461, ASP146O, ASP1551, ASP155O, ASP33O, GLN1491, GLN149O, GLU1571, GLU32O, GLU37O, GLY35O, GLY38O, ILE1501, ILE150O, LEU1511, LEU151O, LEU1541, LEU154O, LEU1581, LEU34O, LEU36O, LYS1351, LYS1361, LYS1401, LYS1421, LYS1451, LYS1561, LYS156O, MET1531, MET153O, PHE1431, PHE1521, PHE152O, PHE39O, PRO1481, PRO148O, PRO83O, SER1471, SER147O
• 2-3: ALA1053, ALA1063, ALA1083, ALA1182, ALA1323, ARG1172, ARG1173, ARG642, ASN1253, ASN592, ASN652, ASP1132, ASP1393, ASP632, GLN1273, GLU1033, GLU1092, GLU1093, GLU1103, GLU1212, GLU1213, GLU1293, GLU1303, GLU1313, GLU943, ILE1013, ILE1243, LEU1043, LEU1073, LEU1202, LEU1203, LYS1122, LYS1353, LYS1363, LYS1423, LYS953, LYS993, MET12, PHE1192, PHE1233, SER1152, SER1333, SER983, THR1162, TRP1222, TRP1223, TYR1023, TYR1142, TYR602, TYR622, TYR913, VAL1283
• 2-D: GLU4D, LYS1122
• 2-G: ALA1442, ASN41G, ASP1392, ASP1462, ASP1552, ASP155G, ASP33G, GLN1492, GLN149G, GLU1572, GLU32G, GLU37G, GLY35G, GLY38G, ILE1502, ILE150G, LEU1412, LEU1512, LEU151G, LEU1542, LEU1582, LEU34G, LEU36G, LYS1362, LYS1402, LYS1452, LYS1562, LYS156G, MET1532, MET153G, PHE1432, PHE1522, PHE152G, PHE39G, PRO1482, PRO148G, PRO83G, SER1472, SER147G
• 2-H: ALA144H, ALA160H, ASP139H, ASP146H, ASP1552, ASP155H, ASP332, GLN1492, GLN149H, GLU157H, GLU372, GLY352, GLY382, ILE1502, ILE150H, LEU1512, LEU151H, LEU1542, LEU154H, LEU158H, LEU342, LEU362, LYS136H, LYS140H, LYS145H, LYS1562, LYS156H, MET1532, MET153H, PHE143H, PHE1522, PHE152H, PRO1482, PRO148H, PRO832, SER1472, SER147H
• 2-K: ALA212, ALA21K, ALA262, ALA26K, ALA282, ALA28K, ALA292, ALA29K, ALA402, ALA40K, ALA452, ALA45K, ALA472, ALA47K, ALA542, ALA54K, ARG562, ARG56K, ARG672, ARG67K, ASN112, ASN11K, ASN152, ASN15K, ASN412, ASN41K, ASN592, ASN59K, ASN652, ASN65K, ASP332, ASP33K, ASP632, ASP63K, ASP712, ASP71K, GLU322, GLU32K, GLU372, GLU37K, GLU482, GLU48K, GLU492, GLU49K, GLU502, GLU50K, GLU692, GLU69K, GLU722, GLU72K, GLU792, GLU79K, GLY1672, GLY167K, GLY352, GLY35K, GLY522, GLY52K, GLY662, GLY66K, HIS532, HIS53K, ILE512, ILE51K, ILE612, ILE61K, ILE732, ILE73K, LEU142, LEU14K, LEU1652, LEU165K, LEU182, LEU18K, LEU232, LEU23K, LEU342, LEU34K, LEU552, LEU55K, LEU702, LEU70K, LEU72, LEU7K, LYS1642, LYS164K, LYS442, LYS44K, LYS752, LYS75K, LYS782, LYS78K, MET272, MET27K, MET432, MET43K, PHE252, PHE25K, PHE312, PHE31K, PHE572, PHE57K, PRO1632, PRO163K, PRO1662, PRO166K, PRO742, PRO74K, PRO762, PRO76K, PRO772, PRO77K, TRP802, TRP80K, TYR192, TYR19K, TYR222, TYR22K, TYR242, TYR24K, TYR302, TYR30K, TYR582, TYR58K, TYR622, TYR62K, VAL682, VAL68K
• 2-Y: ALA1052, ALA1062, ALA1082, ALA118Y, ALA1322, ARG1172, ARG117Y, ARG64Y, ASN1252, ASN59Y, ASN65Y, ASP113Y, ASP1392, ASP63Y, GLN1272, GLU1032, GLU1092, GLU109Y, GLU1102, GLU1212, GLU121Y, GLU1262, GLU1292, GLU1302, GLU1312, GLU942, ILE1012, ILE1242, LEU1042, LEU1072, LEU1202, LEU120Y, LYS112Y, LYS1352, LYS1362, LYS952, LYS992, MET1Y, PHE119Y, SER115Y, SER1332, SER982, THR116Y, TRP1222, TRP122Y, TYR1022, TYR114Y, TYR60Y, TYR62Y, TYR912, VAL1282, VAL1342
• 3-9: GLN1493, GLN1499, ILE1503, MET1533, MET1539, PHE1523, SER1479
• 3-C: LYS1123, LYS95C, LYS99C, TYR1143
• 3-D: ALA1063, ALA1083, ALA9D, ARG53, ARG5D, ARG64D, ASP1133, ASP113D, ASP12D, GLU1093, GLU1103, GLU110D, GLU1113, GLU111D, GLU43, GLU4D, LEU1073, LEU107D, LEU23, LEU2D, LEU73, LEU7D, LYS1123, LYS112D, LYS8D, MET13, MET1D, MET63, MET6D, SER33, SER3D, TYR1143
• 3-K: ALA1443, ASP1393, ASP1463, ASP1553, ASP155K, ASP33K, GLN1493, GLN149K, GLU1573, GLU32K, GLU37K, GLY35K, GLY38K, ILE1503, ILE150K, LEU1513, LEU151K, LEU1543, LEU154K, LEU1583, LEU34K, LEU36K, LYS1363, LYS1403, LYS1453, LYS1563, LYS156K, MET1533, MET153K, PHE1433, PHE1523, PHE152K, PHE39K, PRO1483, PRO148K, PRO83K, SER1473, SER147K
• 3-L: ALA213, ALA21L, ALA263, ALA26L, ALA283, ALA28L, ALA293, ALA29L, ALA403, ALA40L, ALA453, ALA45L, ALA473, ALA47L, ALA543, ALA54L, ARG563, ARG56L, ARG673, ARG67L, ASN113, ASN11L, ASN153, ASN15L, ASN413, ASN41L, ASN593, ASN59L, ASN653, ASN65L, ASP333, ASP33L, ASP633, ASP63L, ASP713, ASP71L, GLU323, GLU32L, GLU373, GLU37L, GLU483, GLU48L, GLU493, GLU49L, GLU503, GLU50L, GLU693, GLU69L, GLU723, GLU72L, GLU793, GLU79L, GLY1673, GLY167L, GLY353, GLY35L, GLY523, GLY52L, GLY663, GLY66L, HIS533, HIS53L, ILE513, ILE51L, ILE613, ILE61L, ILE733, ILE73L, LEU143, LEU14L, LEU1653, LEU165L, LEU183, LEU18L, LEU233, LEU23L, LEU343, LEU34L, LEU553, LEU55L, LEU703, LEU70L, LEU73, LEU7L, LYS1643, LYS164L, LYS443, LYS44L, LYS753, LYS75L, LYS783, LYS78L, LYS8L, MET273, MET27L, MET433, MET43L, PHE253, PHE25L, PHE313, PHE31L, PHE573, PHE57L, PRO1633, PRO163L, PRO1663, PRO166L, PRO743, PRO74L, PRO763, PRO76L, PRO773, PRO77L, TRP803, TRP80L, TYR193, TYR19L, TYR223, TYR22L, TYR243, TYR24L, TYR303, TYR30L, TYR583, TYR58L, TYR623, TYR62L, VAL683, VAL68L
• 3-Q: ALA144Q, ASN413, ASP139Q, ASP146Q, ASP1553, ASP155Q, ASP333, GLN1493, GLN149Q, GLU157Q, GLU323, GLU373, GLY353, GLY383, ILE137Q, ILE1503, ILE150Q, LEU141Q, LEU1513, LEU151Q, LEU1543, LEU154Q, LEU158Q, LEU343, LEU363, LYS135Q, LYS136Q, LYS140Q, LYS145Q, LYS1563, LYS156Q, MET1533, MET153Q, PHE143Q, PHE1523, PHE152Q, PRO1483, PRO148Q, PRO833, SER133Q, SER1473, SER147Q
• 3-Y: ALA105Y, ALA106Y, ALA108Y, ALA1183, ALA132Y, ARG1173, ARG117Y, ARG643, ASN125Y, ASN593, ASN653, ASP1133, ASP139Y, ASP633, GLN127Y, GLU103Y, GLU1093, GLU109Y, GLU110Y, GLU1213, GLU121Y, GLU126Y, GLU129Y, GLU131Y, GLU94Y, ILE101Y, ILE124Y, LEU104Y, LEU107Y, LEU1203, LEU120Y, LYS1123, LYS135Y, LYS136Y, LYS95Y, LYS99Y, MET13, PHE1193, SER1153, SER133Y, SER98Y, THR1163, TRP1223, TRP122Y, TYR102Y, TYR1143, TYR603, TYR623, TYR91Y, VAL128Y
• 4-8: ALA1058, ALA1068, ALA1088, ALA1184, ALA1328, ARG1174, ARG1178, ARG644, ASN1258, ASN594, ASN654, ASP1134, ASP1398, ASP634, GLN1278, GLU1038, GLU1094, GLU1098, GLU1108, GLU1214, GLU1218, GLU1268, GLU1298, GLU1308, GLU1318, ILE1018, ILE1248, LEU1048, LEU1078, LEU1204, LEU1208, LEU24, LYS1124, LYS1358, LYS1368, LYS958, LYS998, MET14, PHE1194, PHE1238, SER1154, SER1338, SER988, THR1164, TRP1224, TRP1228, TYR1028, TYR1144, TYR604, TYR624, TYR918, VAL1288
• 4-9: ALA1054, ALA1064, ALA1084, ALA1189, ALA1324, ARG1174, ARG1179, ARG649, ASN1254, ASN599, ASN659, ASP1139, ASP1394, ASP639, GLN1274, GLU1034, GLU1094, GLU1099, GLU1104, GLU1214, GLU1219, GLU1264, GLU1294, GLU1304, GLU1314, GLU944, ILE1014, ILE1244, LEU1044, LEU1074, LEU1204, LEU1209, LEU1384, LYS1129, LYS1354, LYS1364, LYS1424, LYS954, LYS994, MET19, PHE1199, PHE1234, SER1159, SER1334, SER984, THR1169, TRP1224, TRP1229, TYR1024, TYR1149, TYR609, TYR629, TYR914, VAL1284
• 4-M: ALA214, ALA21M, ALA264, ALA26M, ALA284, ALA28M, ALA294, ALA29M, ALA404, ALA40M, ALA454, ALA474, ALA47M, ALA544, ALA54M, ARG564, ARG56M, ARG674, ARG67M, ASN114, ASN11M, ASN154, ASN15M, ASN414, ASN41M, ASN594, ASN59M, ASN654, ASN65M, ASP334, ASP33M, ASP634, ASP63M, ASP714, ASP71M, GLU174, GLU324, GLU32M, GLU374, GLU37M, GLU484, GLU48M, GLU494, GLU49M, GLU504, GLU50M, GLU694, GLU69M, GLU724, GLU72M, GLU794, GLU79M, GLY1674, GLY167M, GLY354, GLY35M, GLY524, GLY52M, GLY664, GLY66M, HIS534, ILE514, ILE51M, ILE614, ILE61M, ILE734, ILE73M, LEU144, LEU14M, LEU1654, LEU165M, LEU184, LEU18M, LEU234, LEU23M, LEU344, LEU34M, LEU554, LEU55M, LEU704, LEU70M, LEU74, LEU7M, LYS1644, LYS164M, LYS444, LYS44M, LYS754, LYS75M, LYS784, LYS78M, MET274, MET27M, MET434, MET43M, PHE254, PHE25M, PHE314, PHE31M, PHE574, PHE57M, PRO1634, PRO163M, PRO1664, PRO166M, PRO744, PRO74M, PRO764, PRO76M, PRO774, PRO77M, TRP804, TRP80M, TYR194, TYR19M, TYR224, TYR22M, TYR244, TYR24M, TYR304, TYR30M, TYR584, TYR58M, TYR624, TYR62M, VAL684, VAL68M
• 4-P: ALA144P, ASP139P, ASP146P, ASP1554, ASP155P, ASP334, GLN1494, GLN149P, GLU157P, GLU324, GLU374, GLY354, GLY384, ILE1504, ILE150P, LEU1514, LEU151P, LEU154P, LEU344, LEU364, LYS136P, LYS140P, LYS145P, LYS1564, LYS156P, MET1534, MET153P, PHE143P, PHE1524, PHE394, PRO1484, PRO148P, PRO834, SER133P, SER1474, SER147P
• 4-R: ALA1444, ASN41R, ASP1394, ASP1464, ASP1554, ASP155R, ASP33R, GLN1494, GLN149R, GLU1574, GLU32R, GLU37R, GLY35R, GLY38R, ILE1504, ILE150R, LEU1514, LEU151R, LEU1544, LEU1584, LEU34R, LEU36R, LYS1364, LYS1404, LYS1424, LYS1454, LYS1564, LYS156R, MET1534, MET153R, PHE1434, PHE1524, PHE152R, PHE39R, PRO1484, PRO148R, PRO83R, SER1474, SER147R
• 4-Z: GLN1494, GLN149Z, ILE1504, ILE150Z, MET1534, MET153Z, SER1474
• 5-6: ALA1056, ALA1066, ALA1086, ALA1185, ALA1326, ARG1175, ARG1176, ARG645, ASN1256, ASN595, ASN655, ASP1135, ASP1396, ASP635, GLN1276, GLU1036, GLU1095, GLU1096, GLU1106, GLU1215, GLU1216, GLU1266, GLU1296, GLU1306, GLU1316, ILE1016, ILE1246, LEU1046, LEU1076, LEU1205, LEU1206, LEU1386, LYS1125, LYS1356, LYS1366, LYS1426, LYS956, LYS996, MET15, PHE1195, PHE1236, SER1155, SER1336, SER986, THR1165, TRP1225, TRP1226, TYR1026, TYR1145, TYR605, TYR625, TYR916, VAL1286
• 5-J: ALA1445, ASP1395, ASP1465, ASP1555, ASP155J, ASP33J, GLN1495, GLN149J, GLU1575, GLU37J, GLY35J, GLY38J, ILE1505, ILE150J, LEU1515, LEU151J, LEU1545, LEU154J, LEU1585, LEU34J, LEU36J, LYS1365, LYS1405, LYS1455, LYS1565, LYS156J, MET1535, MET153J, PHE1435, PHE1525, PHE152J, PRO1485, PRO148J, PRO83J, SER1335, SER1475, SER147J
• 5-L: ALA144L, ASN415, ASP139L, ASP146L, ASP1555, ASP155L, ASP335, GLN1495, GLN149L, GLU157L, GLU325, GLU375, GLY355, GLY385, ILE1505, ILE150L, LEU1515, LEU151L, LEU154L, LEU345, LEU365, LYS136L, LYS140L, LYS145L, LYS1565, LYS156L, MET1535, MET153L, PHE143L, PHE1525, PHE152L, PRO1485, PRO148L, PRO835, SER1475, SER147L
• 5-N: ALA215, ALA21N, ALA265, ALA26N, ALA285, ALA28N, ALA295, ALA29N, ALA405, ALA40N, ALA455, ALA45N, ALA475, ALA47N, ALA545, ALA54N, ARG565, ARG56N, ARG675, ARG67N, ASN115, ASN11N, ASN155, ASN15N, ASN415, ASN41N, ASN595, ASN59N, ASN655, ASN65N, ASP335, ASP33N, ASP635, ASP63N, ASP715, ASP71N, GLU17N, GLU325, GLU32N, GLU375, GLU37N, GLU485, GLU48N, GLU495, GLU49N, GLU505, GLU50N, GLU695, GLU69N, GLU725, GLU72N, GLU795, GLU79N, GLY1675, GLY167N, GLY355, GLY35N, GLY525, GLY52N, GLY665, GLY66N, HIS535, HIS53N, ILE515, ILE51N, ILE615, ILE61N, ILE735, ILE73N, LEU145, LEU14N, LEU1655, LEU165N, LEU185, LEU18N, LEU235, LEU23N, LEU345, LEU34N, LEU555, LEU55N, LEU705, LEU70N, LEU75, LEU7N, LYS1645, LYS164N, LYS445, LYS44N, LYS755, LYS75N, LYS785, LYS78N, MET275, MET27N, MET435, MET43N, PHE255, PHE25N, PHE315, PHE31N, PHE575, PHE57N, PRO1635, PRO163N, PRO1665, PRO166N, PRO745, PRO74N, PRO765, PRO76N, PRO775, PRO77N, TRP805, TRP80N, TYR195, TYR19N, TYR225, TYR22N, TYR245, TYR24N, TYR305, TYR30N, TYR585, TYR58N, TYR625, TYR62N, VAL685, VAL68N
• 5-Y: GLN1495, GLN149Y, ILE1505, ILE150Y, LYS1565, LYS156Y, MET1535, MET153Y, PHE152Y, SER1475, SER147Y
• 6-8: GLN1496, GLN1498, ILE1506, ILE1508, MET1536, MET1538, SER1478
• 6-M: ALA144M, ALA406, ASP139M, ASP146M, ASP1556, ASP155M, ASP336, GLN1496, GLN149M, GLU157M, GLU326, GLU376, GLY356, GLY386, ILE1506, ILE150M, LEU141M, LEU1516, LEU151M, LEU154M, LEU158M, LEU346, LEU366, LYS136M, LYS140M, LYS145M, LYS1566, LYS156M, MET1536, MET153M, PHE143M, PHE1526, PHE152M, PHE316, PHE396, PRO1486, PRO148M, PRO836, SER1476, SER147M
• 6-N: ALA1446, ASP1396, ASP1466, ASP1556, ASP155N, ASP33N, GLN1496, GLN149N, GLU1576, GLU37N, GLY35N, GLY38N, ILE1506, ILE150N, LEU1516, LEU151N, LEU1546, LEU1586, LEU34N, LEU36N, LYS1366, LYS1406, LYS1456, LYS1566, LYS156N, MET1536, MET153N, PHE1436, PHE1526, PHE152N, PHE39N, PRO1486, PRO148N, PRO83N, SER1336, SER1476, SER147N
• 6-O: ALA216, ALA21O, ALA266, ALA26O, ALA286, ALA28O, ALA296, ALA29O, ALA406, ALA40O, ALA45O, ALA476, ALA47O, ALA546, ALA54O, ARG16O, ARG566, ARG56O, ARG676, ARG67O, ASN116, ASN11O, ASN156, ASN15O, ASN416, ASN41O, ASN596, ASN59O, ASN656, ASN65O, ASP336, ASP33O, ASP636, ASP63O, ASP716, ASP71O, GLU326, GLU32O, GLU376, GLU37O, GLU486, GLU48O, GLU496, GLU49O, GLU506, GLU50O, GLU696, GLU69O, GLU726, GLU72O, GLU796, GLU79O, GLY1676, GLY167O, GLY356, GLY35O, GLY526, GLY52O, GLY666, GLY66O, HIS536, HIS53O, ILE516, ILE51O, ILE616, ILE61O, ILE736, ILE73O, LEU146, LEU14O, LEU1656, LEU165O, LEU186, LEU18O, LEU236, LEU23O, LEU346, LEU34O, LEU556, LEU55O, LEU706, LEU70O, LEU76, LEU7O, LYS1646, LYS164O, LYS446, LYS44O, LYS756, LYS75O, LYS786, LYS78O, LYS8O, MET276, MET27O, MET436, MET43O, PHE256, PHE25O, PHE316, PHE31O, PHE576, PHE57O, PRO1636, PRO163O, PRO1666, PRO166O, PRO746, PRO74O, PRO766, PRO76O, PRO776, PRO77O, TRP806, TRP80O, TYR196, TYR19O, TYR226, TYR22O, TYR246, TYR24O, TYR306, TYR30O, TYR586, TYR58O, TYR626, TYR62O, VAL686, VAL68O
• 7-I: ALA1447, ASP1397, ASP1467, ASP1557, ASP155I, ASP33I, GLN1497, GLN149I, GLU1577, GLU32I, GLU37I, GLY35I, GLY38I, ILE1507, ILE150I, LEU1517, LEU151I, LEU1547, LEU1587, LEU34I, LEU36I, LYS1367, LYS1407, LYS1457, LYS1567, LYS156I, MET1537, MET153I, PHE1437, PHE1527, PHE152I, PHE39I, PRO1487, PRO148I, PRO83I, SER1477, SER147I
• 7-O: ALA144O, ALA160O, ASP139O, ASP1557, ASP155O, ASP337, GLN1497, GLN149O, GLU157O, GLU327, GLU377, GLY357, GLY387, ILE1507, ILE150O, LEU1517, LEU151O, LEU154O, LEU158O, LEU347, LEU367, LYS135O, LYS136O, LYS140O, LYS145O, LYS1567, LYS156O, MET1537, MET153O, PHE143O, PHE1527, PHE152O, PRO1487, PRO148O, PRO837, SER1477, SER147O
• 7-P: ALA217, ALA21P, ALA267, ALA26P, ALA287, ALA28P, ALA297, ALA29P, ALA407, ALA40P, ALA45P, ALA477, ALA47P, ALA547, ALA54P, ARG167, ARG567, ARG56P, ARG677, ARG67P, ASN117, ASN11P, ASN157, ASN15P, ASN417, ASN41P, ASN597, ASN59P, ASN657, ASN65P, ASP337, ASP33P, ASP637, ASP63P, ASP717, ASP71P, GLU17P, GLU327, GLU32P, GLU377, GLU37P, GLU487, GLU48P, GLU497, GLU49P, GLU507, GLU50P, GLU697, GLU69P, GLU727, GLU72P, GLU797, GLU79P, GLY1677, GLY167P, GLY357, GLY35P, GLY527, GLY52P, GLY667, GLY66P, HIS537, ILE517, ILE51P, ILE617, ILE61P, ILE737, ILE73P, LEU147, LEU14P, LEU1657, LEU165P, LEU187, LEU18P, LEU237, LEU23P, LEU347, LEU34P, LEU557, LEU55P, LEU707, LEU70P, LEU77, LEU7P, LYS1647, LYS164P, LYS447, LYS44P, LYS757, LYS75P, LYS787, LYS78P, LYS8P, MET277, MET27P, MET437, MET43P, PHE257, PHE25P, PHE317, PHE31P, PHE577, PHE57P, PRO1637, PRO163P, PRO1667, PRO166P, PRO747, PRO74P, PRO767, PRO76P, PRO777, PRO77P, TRP807, TRP80P, TYR197, TYR19P, TYR227, TYR22P, TYR247, TYR24P, TYR307, TYR30P, TYR587, TYR58P, TYR627, TYR62P, VAL687, VAL68P
• 7-Z: ALA105Z, ALA106Z, ALA108Z, ALA1187, ALA132Z, ARG1177, ARG117Z, ARG647, ASN125Z, ASN597, ASN657, ASP1137, ASP139Z, ASP637, GLN127Z, GLU103Z, GLU1097, GLU109Z, GLU110Z, GLU1217, GLU121Z, GLU126Z, GLU129Z, GLU130Z, GLU131Z, ILE101Z, ILE124Z, LEU104Z, LEU107Z, LEU1207, LEU120Z, LEU138Z, LYS1127, LYS135Z, LYS136Z, LYS142Z, LYS95Z, LYS99Z, MET17, PHE1197, SER1157, SER133Z, SER98Z, THR1167, TRP1227, TRP122Z, TYR102Z, TYR1147, TYR607, TYR627, TYR91Z, VAL128Z
• 8-9: ALA1059, ALA1069, ALA1089, ALA1188, ALA1329, ARG1178, ARG1179, ARG648, ASN1259, ASN598, ASN658, ASP1138, ASP1399, ASP638, GLN1279, GLU1039, GLU1098, GLU1099, GLU1109, GLU1218, GLU1219, GLU1269, GLU1299, GLU1309, GLU1319, GLU949, ILE1019, ILE1249, LEU1049, LEU1079, LEU1208, LEU1209, LYS1128, LYS1359, LYS1369, LYS959, LYS999, MET18, PHE1198, PHE1239, SER1158, SER1339, SER989, THR1168, TRP1228, TRP1229, TYR1029, TYR1148, TYR608, TYR628, TYR919, VAL1289
• 8-M: ALA1448, ALA1608, ASN41M, ASP1398, ASP1468, ASP1558, ASP155M, ASP33M, GLN1498, GLN149M, GLU1578, GLU32M, GLU37M, GLY35M, GLY38M, ILE1378, ILE1508, ILE150M, LEU1418, LEU1518, LEU151M, LEU1548, LEU1588, LEU34M, LEU36M, LYS1368, LYS1408, LYS1458, LYS1568, LYS156M, MET1538, MET153M, PHE1438, PHE1528, PHE152M, PHE39M, PRO1488, PRO148M, PRO83M, SER1478, SER147M
• 8-N: ALA144N, ASP139N, ASP146N, ASP1558, ASP155N, ASP338, GLN1498, GLN149N, GLU157N, GLU328, GLU378, GLY358, GLY388, ILE1508, ILE150N, LEU1518, LEU151N, LEU154N, LEU158N, LEU348, LEU368, LYS136N, LYS140N, LYS145N, LYS1568, LYS156N, MET1538, MET153N, PHE143N, PHE1528, PHE152N, PRO1488, PRO148N, PRO838, SER1478, SER147N
• 8-Q: ALA218, ALA21Q, ALA268, ALA26Q, ALA288, ALA28Q, ALA298, ALA29Q, ALA408, ALA40Q, ALA458, ALA45Q, ALA478, ALA47Q, ALA548, ALA54Q, ARG568, ARG56Q, ARG678, ARG67Q, ASN118, ASN11Q, ASN158, ASN15Q, ASN418, ASN41Q, ASN598, ASN59Q, ASN658, ASN65Q, ASP338, ASP33Q, ASP638, ASP63Q, ASP718, ASP71Q, GLU178, GLU328, GLU32Q, GLU378, GLU37Q, GLU48, GLU488, GLU48Q, GLU498, GLU49Q, GLU508, GLU50Q, GLU698, GLU69Q, GLU728, GLU72Q, GLU798, GLU79Q, GLY1678, GLY167Q, GLY358, GLY35Q, GLY528, GLY52Q, GLY668, GLY66Q, HIS538, ILE518, ILE51Q, ILE618, ILE61Q, ILE738, ILE73Q, LEU148, LEU14Q, LEU1658, LEU165Q, LEU188, LEU18Q, LEU238, LEU23Q, LEU348, LEU34Q, LEU558, LEU55Q, LEU708, LEU70Q, LEU78, LEU7Q, LYS1648, LYS164Q, LYS448, LYS44Q, LYS758, LYS75Q, LYS788, LYS78Q, MET278, MET27Q, MET438, MET43Q, PHE258, PHE25Q, PHE318, PHE31Q, PHE578, PHE57Q, PRO1638, PRO163Q, PRO1668, PRO166Q, PRO748, PRO74Q, PRO768, PRO76Q, PRO778, PRO77Q, TRP808, TRP80Q, TYR198, TYR19Q, TYR228, TYR22Q, TYR248, TYR24Q, TYR308, TYR30Q, TYR588, TYR58Q, TYR628, TYR62Q, VAL688, VAL68Q
• 9-K: ALA144K, ASN419, ASP139K, ASP146K, ASP1559, ASP155K, ASP339, GLN1499, GLN149K, GLU157K, GLU329, GLU379, GLY359, GLY389, ILE1509, ILE150K, LEU1519, LEU151K, LEU1549, LEU154K, LEU158K, LEU349, LEU369, LYS136K, LYS140K, LYS145K, LYS1569, LYS156K, MET1539, MET153K, PHE143K, PHE1529, PHE152K, PRO1489, PRO148K, PRO839, SER1479, SER147K
• 9-Q: ALA1449, ASP1399, ASP1469, ASP1559, ASP155Q, ASP33Q, GLN1499, GLN149Q, GLU1579, GLU32Q, GLU37Q, GLY35Q, GLY38Q, ILE1509, ILE150Q, LEU1519, LEU151Q, LEU1549, LEU1589, LEU34Q, LEU36Q, LYS1369, LYS1409, LYS1459, LYS1569, LYS156Q, MET1539, MET153Q, PHE1439, PHE1529, PHE152Q, PRO1489, PRO148Q, PRO83Q, SER1479, SER147Q
• 9-R: ALA219, ALA21R, ALA269, ALA26R, ALA289, ALA28R, ALA299, ALA29R, ALA409, ALA40R, ALA459, ALA45R, ALA479, ALA47R, ALA549, ALA54R, ARG569, ARG56R, ARG679, ARG67R, ASN119, ASN11R, ASN159, ASN15R, ASN419, ASN41R, ASN599, ASN59R, ASN659, ASN65R, ASP339, ASP33R, ASP639, ASP63R, ASP719, ASP71R, GLU17R, GLU329, GLU32R, GLU379, GLU37R, GLU489, GLU48R, GLU499, GLU49R, GLU509, GLU50R, GLU699, GLU69R, GLU729, GLU72R, GLU799, GLU79R, GLY1679, GLY167R, GLY359, GLY35R, GLY529, GLY52R, GLY669, GLY66R, HIS539, HIS53R, ILE519, ILE51R, ILE619, ILE61R, ILE739, ILE73R, LEU149, LEU14R, LEU1659, LEU165R, LEU189, LEU18R, LEU239, LEU23R, LEU349, LEU34R, LEU559, LEU55R, LEU709, LEU70R, LEU79, LEU7R, LYS1649, LYS164R, LYS449, LYS44R, LYS759, LYS75R, LYS789, LYS78R, MET279, MET27R, MET439, MET43R, PHE259, PHE25R, PHE319, PHE31R, PHE579, PHE57R, PRO1639, PRO163R, PRO1669, PRO166R, PRO749, PRO74R, PRO769, PRO76R, PRO779, PRO77R, TRP809, TRP80R, TYR199, TYR19R, TYR229, TYR22R, TYR249, TYR24R, TYR309, TYR30R, TYR589, TYR58R, TYR629, TYR62R, VAL689, VAL68R
• A-B: GLN149A, GLN149B, ILE150A, MET153A, MET153B
• A-C: ALA105A, ALA106A, ALA108A, ALA118C, ALA132A, ARG117A, ARG117C, ARG64C, ASN125A, ASN59C, ASN65C, ASP113C, ASP139A, ASP63C, GLN127A, GLU103A, GLU109A, GLU109C, GLU110A, GLU121A, GLU121C, GLU126A, GLU129A, GLU130A, GLU131A, GLU94A, ILE101A, ILE124A, LEU104A, LEU107A, LEU120A, LEU120C, LEU2C, LYS112C, LYS135A, LYS136A, LYS95A, LYS99A, MET1C, PHE119C, SER115C, SER133A, SER98A, THR116C, TRP122A, TRP122C, TYR102A, TYR114C, TYR60C, TYR62C, TYR91A, VAL128A, VAL134A
• A-D: ALA105D, ALA106D, ALA108D, ALA118A, ALA132D, ARG117A, ARG117D, ARG64A, ASN125D, ASN59A, ASN65A, ASP113A, ASP139D, ASP63A, GLN127D, GLU103D, GLU109A, GLU109D, GLU110D, GLU121A, GLU121D, GLU126D, GLU129D, GLU130D, GLU131D, ILE101D, ILE124D, LEU104D, LEU107D, LEU120A, LEU120D, LYS112A, LYS135D, LYS136D, LYS142D, LYS95D, LYS99D, MET1A, PHE119A, PHE123D, SER115A, SER133D, SER98D, THR116A, TRP122A, TRP122D, TYR102D, TYR114A, TYR60A, TYR62A, TYR91D, VAL128D
• A-S: ALA21A, ALA21S, ALA26A, ALA26S, ALA28A, ALA28S, ALA29A, ALA29S, ALA40A, ALA40S, ALA45A, ALA45S, ALA47A, ALA47S, ALA54A, ALA54S, ARG56A, ARG56S, ARG67A, ARG67S, ASN11A, ASN11S, ASN15A, ASN15S, ASN41A, ASN41S, ASN59A, ASN59S, ASN65A, ASN65S, ASP33A, ASP33S, ASP63A, ASP63S, ASP71A, ASP71S, GLU17A, GLU32A, GLU32S, GLU37A, GLU37S, GLU48A, GLU48S, GLU49A, GLU49S, GLU50A, GLU50S, GLU69A, GLU69S, GLU72A, GLU72S, GLU79A, GLU79S, GLY167A, GLY167S, GLY35A, GLY35S, GLY52A, GLY52S, GLY66A, GLY66S, HIS53S, ILE51A, ILE51S, ILE61A, ILE61S, ILE73A, ILE73S, LEU14A, LEU14S, LEU165A, LEU165S, LEU18A, LEU18S, LEU23A, LEU23S, LEU34A, LEU34S, LEU55A, LEU55S, LEU70A, LEU70S, LEU7A, LEU7S, LYS164A, LYS164S, LYS44A, LYS44S, LYS75A, LYS75S, LYS78A, LYS78S, LYS8S, MET27A, MET27S, MET43A, MET43S, PHE25A, PHE25S, PHE31A, PHE31S, PHE57A, PHE57S, PRO163A, PRO163S, PRO166A, PRO166S, PRO74A, PRO74S, PRO76A, PRO76S, PRO77A, PRO77S, TRP80A, TRP80S, TYR19A, TYR19S, TYR22A, TYR22S, TYR24A, TYR24S, TYR30A, TYR30S, TYR58A, TYR58S, TYR62A, TYR62S, VAL68A, VAL68S
• A-U: ALA144A, ASN41U, ASP139A, ASP146A, ASP155A, ASP155U, ASP33U, GLN149A, GLN149U, GLU157A, GLU37U, GLY35U, GLY38U, ILE150A, ILE150U, LEU141A, LEU151A, LEU151U, LEU154A, LEU154U, LEU158A, LEU34U, LEU36U, LYS135A, LYS136A, LYS140A, LYS145A, LYS156A, LYS156U, MET153A, MET153U, PHE143A, PHE152A, PHE152U, PHE39U, PRO148A, PRO148U, PRO83U, SER147A, SER147U
• A-W: ALA144W, ASP139W, ASP146W, ASP155A, ASP155W, ASP33A, GLN149A, GLN149W, GLU157W, GLU32A, GLU37A, GLY35A, GLY38A, ILE150A, ILE150W, LEU141W, LEU151A, LEU151W, LEU154W, LEU158W, LEU34A, LEU36A, LYS136W, LYS140W, LYS145W, LYS156A, LYS156W, MET153A, MET153W, PHE143W, PHE152A, PHE152W, PRO148A, PRO148W, PRO83A, SER133W, SER147A, SER147W
• B-E: ALA105B, ALA106B, ALA108B, ALA118E, ALA132B, ARG117B, ARG117E, ARG64E, ASN125B, ASN59E, ASN65E, ASP113E, ASP139B, ASP63E, GLN127B, GLU103B, GLU109B, GLU109E, GLU110B, GLU121B, GLU121E, GLU126B, GLU129B, GLU130B, GLU131B, ILE101B, ILE124B, LEU104B, LEU107B, LEU120B, LEU120E, LYS112E, LYS135B, LYS136B, LYS95B, LYS99B, MET1E, PHE119E, SER115E, SER133B, SER98B, THR116E, TRP122B, TRP122E, TYR102B, TYR114E, TYR60E, TYR62E, TYR91B, VAL128B, VAL134B
• B-T: ALA21B, ALA21T, ALA26B, ALA26T, ALA28B, ALA28T, ALA29B, ALA29T, ALA40B, ALA40T, ALA45B, ALA45T, ALA47B, ALA47T, ALA54B, ALA54T, ARG16B, ARG56B, ARG56T, ARG67B, ARG67T, ASN11B, ASN11T, ASN15B, ASN15T, ASN41B, ASN41T, ASN59B, ASN59T, ASN65B, ASN65T, ASP33B, ASP33T, ASP63B, ASP63T, ASP71B, ASP71T, GLU32B, GLU32T, GLU37B, GLU37T, GLU48B, GLU48T, GLU49B, GLU49T, GLU50B, GLU50T, GLU69B, GLU69T, GLU72B, GLU72T, GLU79B, GLU79T, GLY167B, GLY167T, GLY35B, GLY35T, GLY52B, GLY52T, GLY66B, GLY66T, HIS53T, ILE51B, ILE51T, ILE61B, ILE61T, ILE73B, ILE73T, LEU14B, LEU14T, LEU165B, LEU165T, LEU18B, LEU18T, LEU23B, LEU23T, LEU34B, LEU34T, LEU55B, LEU55T, LEU70B, LEU70T, LEU7B, LEU7T, LYS164B, LYS164T, LYS44B, LYS44T, LYS75B, LYS75T, LYS78B, LYS78T, LYS8B, MET27B, MET27T, MET43B, MET43T, PHE25B, PHE25T, PHE31B, PHE31T, PHE57B, PHE57T, PRO163B, PRO163T, PRO166B, PRO166T, PRO74B, PRO74T, PRO76B, PRO76T, PRO77B, PRO77T, TRP80B, TRP80T, TYR19B, TYR19T, TYR22B, TYR22T, TYR24B, TYR24T, TYR30B, TYR30T, TYR58B, TYR58T, TYR62B, TYR62T, VAL68B, VAL68T
• B-U: ALA144U, ASN41B, ASP139U, ASP146U, ASP155B, ASP155U, ASP33B, GLN149B, GLN149U, GLU157U, GLU32B, GLU37B, GLY35B, GLY38B, ILE150B, ILE150U, LEU141U, LEU151B, LEU151U, LEU154B, LEU154U, LEU158U, LEU34B, LEU36B, LYS135U, LYS136U, LYS140U, LYS145U, LYS156B, LYS156U, MET153B, MET153U, PHE143U, PHE152B, PHE152U, PHE39B, PRO148B, PRO148U, PRO83B, SER133U, SER147B, SER147U
• B-W: ALA144B, ASP139B, ASP146B, ASP155B, ASP155W, ASP33W, GLN149B, GLN149W, GLU157B, GLU32W, GLU37W, GLY35W, GLY38W, ILE150B, ILE150W, LEU151B, LEU151W, LEU154B, LEU154W, LEU158B, LEU34W, LEU36W, LYS136B, LYS140B, LYS145B, LYS156B, LYS156W, MET153B, MET153W, PHE143B, PHE152B, PHE152W, PHE39W, PRO148B, PRO148W, PRO83W, SER133B, SER147B, SER147W
• C-D: ALA105C, ALA106C, ALA108C, ALA118D, ALA132C, ARG117C, ARG117D, ARG64D, ASN125C, ASN59D, ASN65D, ASP113D, ASP139C, ASP63D, GLN127C, GLU103C, GLU109C, GLU109D, GLU121C, GLU121D, GLU126C, GLU129C, GLU130C, GLU131C, ILE101C, ILE124C, LEU104C, LEU107C, LEU120C, LEU120D, LEU138C, LEU2D, LYS112D, LYS135C, LYS136C, LYS142C, LYS95C, LYS99C, MET1D, PHE119D, PHE123C, SER115D, SER133C, SER98C, THR116D, TRP122C, TRP122D, TYR102C, TYR114D, TYR60D, TYR62D, TYR91C, VAL128C
• C-G: ASP12C, ASP71C, ASP71G, GLU4C, GLU69C, GLU72C, GLU72G, ILE73G, LYS75G, LYS78G, LYS8C, PRO74C, TYR22G
• C-U: ALA21C, ALA21U, ALA26C, ALA26U, ALA28C, ALA28U, ALA29C, ALA29U, ALA40C, ALA40U, ALA45C, ALA45U, ALA47C, ALA47U, ALA54C, ALA54U, ARG16U, ARG56C, ARG56U, ARG67C, ARG67U, ASN11C, ASN11U, ASN15C, ASN15U, ASN41C, ASN41U, ASN59C, ASN59U, ASN65C, ASN65U, ASP33C, ASP33U, ASP63C, ASP63U, ASP71C, ASP71U, GLU32C, GLU32U, GLU37C, GLU37U, GLU48C, GLU48U, GLU49C, GLU49U, GLU50C, GLU50U, GLU69C, GLU69U, GLU72C, GLU72U, GLU79C, GLU79U, GLY167C, GLY167U, GLY35C, GLY35U, GLY52C, GLY52U, GLY66C, GLY66U, HIS53C, ILE51C, ILE51U, ILE61C, ILE61U, ILE73C, ILE73U, LEU14C, LEU14U, LEU165C, LEU165U, LEU18C, LEU18U, LEU23C, LEU23U, LEU34C, LEU34U, LEU55C, LEU55U, LEU70C, LEU70U, LEU7C, LEU7U, LYS164C, LYS164U, LYS44C, LYS44U, LYS75C, LYS75U, LYS78C, LYS78U, MET27C, MET27U, MET43C, MET43U, PHE25C, PHE25U, PHE31C, PHE31U, PHE57C, PHE57U, PRO163C, PRO163U, PRO166C, PRO166U, PRO74C, PRO74U, PRO76C, PRO76U, PRO77C, PRO77U, TRP80C, TRP80U, TYR19C, TYR19U, TYR22C, TYR22U, TYR24C, TYR24U, TYR30C, TYR30U, TYR58C, TYR58U, TYR62C, TYR62U, VAL68C, VAL68U
• C-V: ALA144C, ASP139C, ASP146C, ASP155C, ASP155V, ASP33V, GLN149C, GLN149V, GLU157C, GLU32V, GLU37V, GLY35V, GLY38V, ILE137C, ILE150C, ILE150V, LEU141C, LEU151C, LEU151V, LEU154C, LEU154V, LEU158C, LEU34V, LEU36V, LYS135C, LYS136C, LYS140C, LYS145C, LYS156C, LYS156V, MET153C, MET153V, PHE143C, PHE152C, PHE152V, PRO148C, PRO148V, PRO83V, SER147C, SER147V
• C-Y: ALA105C, ALA105Y, ALA106C, ALA106Y, ALA108C, ALA108Y, ALA86C, ALA89C, ALA89Y, ALA90C, ALA90Y, ALA9C, ALA9Y, ARG16C, ARG16Y, ARG5C, ARG5Y, ASN11C, ASN11Y, ASN15C, ASN15Y, ASP113Y, ASP12C, ASP12Y, ASP71C, ASP71Y, GLN13Y, GLU103C, GLU103Y, GLU109C, GLU109Y, GLU110C, GLU110Y, GLU111C, GLU111Y, GLU131C, GLU4C, GLU4Y, GLU69C, GLU69Y, GLU72C, GLU72Y, GLU88C, GLU88Y, GLU92C, GLU92Y, GLU94C, GLU94Y, HIS93C, HIS93Y, ILE101C, ILE101Y, ILE73C, ILE73Y, ILE97C, ILE97Y, LEU104C, LEU104Y, LEU107C, LEU107Y, LEU10Y, LEU23C, LEU23Y, LEU70Y, LEU7C, LEU7Y, LYS112C, LYS112Y, LYS142C, LYS75C, LYS75Y, LYS78Y, LYS85C, LYS85Y, LYS8C, LYS8Y, LYS95C, LYS95Y, LYS99C, LYS99Y, MET27C, MET27Y, MET6C, MET6Y, PHE96C, PHE96Y, PRO74C, PRO74Y, PRO76C, PRO76Y, PRO77C, PRO77Y, SER100C, SER100Y, SER20C, SER20Y, SER3C, SER3Y, SER98C, TRP80C, TRP80Y, TYR102C, TYR102Y, TYR19C, TYR19Y, TYR22Y, TYR24Y, TYR91C, TYR91Y
• D-F: GLN149D, GLN149F, ILE150D, ILE150F, MET153D, MET153F, PHE152F, SER147D, SER147F
• D-S: ALA144D, ASP139D, ASP146D, ASP155D, ASP155S, ASP33S, GLN149D, GLN149S, GLU157D, GLU37S, GLY35S, GLY38S, ILE150D, ILE150S, LEU141D, LEU151D, LEU151S, LEU154D, LEU154S, LEU158D, LEU34S, LEU36S, LYS135D, LYS136D, LYS140D, LYS145D, LYS156D, LYS156S, MET153D, MET153S, PHE143D, PHE152D, PHE152S, PHE39S, PRO148D, PRO148S, PRO83S, SER147D, SER147S
• D-V: ALA21D, ALA21V, ALA26D, ALA26V, ALA28D, ALA28V, ALA29D, ALA29V, ALA40D, ALA40V, ALA45D, ALA45V, ALA47D, ALA47V, ALA54D, ALA54V, ARG56D, ARG56V, ARG67D, ARG67V, ASN11D, ASN11V, ASN15D, ASN15V, ASN41D, ASN41V, ASN59D, ASN59V, ASN65D, ASN65V, ASP33D, ASP33V, ASP63D, ASP63V, ASP71D, ASP71V, GLU17D, GLU17V, GLU32D, GLU32V, GLU37D, GLU37V, GLU48D, GLU48V, GLU49D, GLU49V, GLU50D, GLU50V, GLU69D, GLU69V, GLU72D, GLU72V, GLU79D, GLU79V, GLY167D, GLY167V, GLY35D, GLY35V, GLY52D, GLY52V, GLY66D, GLY66V, HIS53D, HIS53V, ILE51D, ILE51V, ILE61D, ILE61V, ILE73D, ILE73V, LEU14D, LEU14V, LEU165D, LEU165V, LEU18D, LEU18V, LEU23D, LEU23V, LEU34D, LEU34V, LEU55D, LEU55V, LEU70D, LEU70V, LEU7D, LEU7V, LYS164D, LYS164V, LYS44D, LYS44V, LYS75D, LYS75V, LYS78D, LYS78V, LYS8D, LYS8V, MET27D, MET27V, MET43D, MET43V, PHE25D, PHE25V, PHE31D, PHE31V, PHE57D, PHE57V, PRO163D, PRO163V, PRO166D, PRO166V, PRO74D, PRO74V, PRO76D, PRO76V, PRO77D, PRO77V, TRP80D, TRP80V, TYR19D, TYR19V, TYR22D, TYR22V, TYR24D, TYR24V, TYR30D, TYR30V, TYR58D, TYR58V, TYR62D, TYR62V, VAL68D, VAL68V
• D-Y: ALA106Y, ARG64D, ASP113D, GLU103Y, GLU109D, GLU110Y, GLU111D, LYS112D, LYS95Y, LYS99Y, MET1D, PHE96Y, SER100Y, TYR102Y, TYR114D
• E-W: ALA21E, ALA21W, ALA26E, ALA26W, ALA28E, ALA28W, ALA29E, ALA29W, ALA40E, ALA40W, ALA45E, ALA45W, ALA47E, ALA47W, ALA54E, ALA54W, ARG56E, ARG56W, ARG67E, ARG67W, ASN11E, ASN11W, ASN15E, ASN15W, ASN41E, ASN41W, ASN59E, ASN59W, ASN65E, ASN65W, ASP33E, ASP33W, ASP63E, ASP63W, ASP71E, ASP71W, GLU17W, GLU32E, GLU32W, GLU37E, GLU37W, GLU48E, GLU48W, GLU49E, GLU49W, GLU4E, GLU50E, GLU69E, GLU69W, GLU72E, GLU72W, GLU79E, GLU79W, GLY167E, GLY167W, GLY35E, GLY35W, GLY52E, GLY52W, GLY66E, GLY66W, HIS53E, ILE51E, ILE51W, ILE61E, ILE61W, ILE73E, ILE73W, LEU14E, LEU14W, LEU165E, LEU165W, LEU18E, LEU18W, LEU23E, LEU23W, LEU34E, LEU34W, LEU55E, LEU55W, LEU70E, LEU70W, LEU7E, LEU7W, LYS164E, LYS164W, LYS44E, LYS44W, LYS75E, LYS75W, LYS78E, LYS78W, LYS8W, MET27E, MET27W, MET43E, MET43W, PHE25E, PHE25W, PHE31E, PHE31W, PHE57E, PHE57W, PRO163E, PRO163W, PRO166E, PRO166W, PRO74E, PRO74W, PRO76E, PRO76W, PRO77E, PRO77W, TRP80E, TRP80W, TYR19E, TYR19W, TYR22E, TYR22W, TYR24E, TYR24W, TYR30E, TYR30W, TYR58E, TYR58W, TYR62E, TYR62W, VAL68E, VAL68W
• E-X: ALA144X, ALA160X, ASP139X, ASP146X, ASP155E, ASP155X, ASP33E, GLN149E, GLN149X, GLU157X, GLU32E, GLU37E, GLY35E, GLY38E, ILE137X, ILE150E, ILE150X, LEU141X, LEU151E, LEU151X, LEU154E, LEU154X, LEU158X, LEU34E, LEU36E, LYS136X, LYS140X, LYS145X, LYS156E, LYS156X, MET153E, MET153X, PHE143X, PHE152E, PHE152X, PRO148E, PRO148X, PRO83E, SER133X, SER147E, SER147X
• F-S: ALA144S, ASN41F, ASP139S, ASP146S, ASP155F, ASP155S, ASP33F, GLN149F, GLN149S, GLU157S, GLU32F, GLU37F, GLY35F, GLY38F, ILE150F, ILE150S, LEU151F, LEU151S, LEU154F, LEU154S, LEU158S, LEU34F, LEU36F, LYS136S, LYS140S, LYS145S, LYS156F, LYS156S, MET153F, MET153S, PHE143S, PHE152F, PHE152S, PHE39F, PRO148F, PRO148S, PRO83F, SER147F, SER147S
• F-X: ALA21F, ALA21X, ALA26F, ALA26X, ALA28F, ALA28X, ALA29F, ALA29X, ALA40F, ALA40X, ALA45F, ALA45X, ALA47F, ALA47X, ALA54F, ALA54X, ARG56F, ARG56X, ARG67F, ARG67X, ASN11F, ASN11X, ASN15F, ASN15X, ASN41F, ASN41X, ASN59F, ASN59X, ASN65F, ASN65X, ASP33F, ASP33X, ASP63F, ASP63X, ASP71F, ASP71X, GLU17X, GLU32F, GLU32X, GLU37F, GLU37X, GLU48F, GLU48X, GLU49F, GLU49X, GLU4F, GLU50F, GLU50X, GLU69F, GLU69X, GLU72F, GLU72X, GLU79F, GLU79X, GLY167F, GLY167X, GLY35F, GLY35X, GLY52F, GLY52X, GLY66F, GLY66X, HIS53F, ILE51F, ILE51X, ILE61F, ILE61X, ILE73F, ILE73X, LEU14F, LEU14X, LEU165F, LEU165X, LEU18F, LEU18X, LEU23F, LEU23X, LEU34F, LEU34X, LEU55F, LEU55X, LEU70F, LEU70X, LEU7F, LEU7X, LYS164F, LYS164X, LYS44F, LYS44X, LYS75F, LYS75X, LYS78F, LYS78X, MET27F, MET27X, MET43F, MET43X, PHE25F, PHE25X, PHE31F, PHE31X, PHE57F, PHE57X, PRO163F, PRO163X, PRO166F, PRO166X, PRO74F, PRO74X, PRO76F, PRO76X, PRO77F, PRO77X, TRP80F, TRP80X, TYR19F, TYR19X, TYR22F, TYR22X, TYR24F, TYR24X, TYR30F, TYR30X, TYR58F, TYR58X, TYR62F, TYR62X, VAL68F, VAL68X
• G-H: GLN149G, GLN149H, ILE150G, ILE150H, LYS156G, LYS156H, MET153G, MET153H, SER147G
• G-I: ALA105G, ALA106G, ALA108G, ALA118I, ALA132G, ARG117G, ARG117I, ARG64I, ASN125G, ASN59I, ASN65I, ASP113I, ASP139G, ASP63I, GLN127G, GLU103G, GLU109G, GLU109I, GLU110G, GLU121G, GLU121I, GLU126G, GLU129G, GLU130G, GLU131G, ILE101G, ILE124G, LEU104G, LEU107G, LEU120G, LEU120I, LEU138G, LYS112I, LYS135G, LYS136G, LYS142G, LYS95G, LYS99G, MET1I, PHE119I, PHE123G, SER115I, SER133G, SER98G, THR116I, TRP122G, TRP122I, TYR102G, TYR114I, TYR60I, TYR62I, TYR91G, VAL128G
• G-J: ALA105J, ALA106J, ALA108J, ALA118G, ALA132J, ARG117G, ARG117J, ARG64G, ASN125J, ASN59G, ASN65G, ASP113G, ASP139J, ASP63G, GLN127J, GLU103J, GLU109G, GLU109J, GLU110J, GLU121G, GLU121J, GLU126J, GLU129J, GLU130J, GLU131J, ILE101J, ILE124J, LEU104J, LEU107J, LEU120G, LEU120J, LYS112G, LYS135J, LYS136J, LYS142J, LYS95J, LYS99J, MET1G, PHE119G, PHE123J, SER115G, SER133J, SER98J, THR116G, TRP122G, TRP122J, TYR102J, TYR114G, TYR60G, TYR62G, TYR91J, VAL128J
• G-U: GLU72G, GLU72U, LYS75G, LYS75U, LYS78G, LYS78U
• G-Y: ALA21G, ALA21Y, ALA26G, ALA26Y, ALA28G, ALA28Y, ALA29G, ALA29Y, ALA40G, ALA40Y, ALA45G, ALA45Y, ALA47G, ALA47Y, ALA54G, ALA54Y, ARG56G, ARG56Y, ARG67G, ARG67Y, ASN11G, ASN11Y, ASN15G, ASN15Y, ASN41G, ASN41Y, ASN59G, ASN59Y, ASN65G, ASN65Y, ASP33G, ASP33Y, ASP63G, ASP63Y, ASP71G, ASP71Y, GLU17Y, GLU32G, GLU32Y, GLU37G, GLU37Y, GLU48G, GLU48Y, GLU49G, GLU49Y, GLU50G, GLU50Y, GLU69G, GLU69Y, GLU72G, GLU72Y, GLU79G, GLU79Y, GLY167G, GLY167Y, GLY35G, GLY35Y, GLY52G, GLY52Y, GLY66G, GLY66Y, HIS53G, ILE51G, ILE51Y, ILE61G, ILE61Y, ILE73G, ILE73Y, LEU14G, LEU14Y, LEU165G, LEU165Y, LEU18G, LEU18Y, LEU23G, LEU23Y, LEU34G, LEU34Y, LEU55G, LEU55Y, LEU70G, LEU70Y, LEU7G, LEU7Y, LYS164G, LYS164Y, LYS44G, LYS44Y, LYS75G, LYS75Y, LYS78G, LYS78Y, MET27G, MET27Y, MET43G, MET43Y, PHE25G, PHE25Y, PHE31G, PHE31Y, PHE57G, PHE57Y, PRO163G, PRO163Y, PRO166G, PRO166Y, PRO74G, PRO74Y, PRO76G, PRO76Y, PRO77G, PRO77Y, TRP80G, TRP80Y, TYR19G, TYR19Y, TYR22G, TYR22Y, TYR24G, TYR24Y, TYR30G, TYR30Y, TYR58G, TYR58Y, TYR62G, TYR62Y, VAL68G, VAL68Y
• H-K: ALA105H, ALA106H, ALA108H, ALA118K, ALA132H, ARG117H, ARG117K, ARG64K, ASN125H, ASN59K, ASN65K, ASP113K, ASP139H, ASP63K, GLN127H, GLU103H, GLU109H, GLU109K, GLU110H, GLU121H, GLU121K, GLU126H, GLU129H, GLU130H, GLU131H, ILE101H, ILE124H, LEU104H, LEU107H, LEU120H, LEU120K, LEU138H, LEU2K, LYS112K, LYS135H, LYS136H, LYS142H, LYS95H, LYS99H, MET1K, PHE119K, PHE123H, SER115K, SER133H, SER98H, THR116K, TRP122H, TRP122K, TYR102H, TYR114K, TYR60K, TYR62K, TYR91H, VAL128H
• H-R: ALA105R, ALA106R, ALA108R, ALA118H, ALA132R, ARG117H, ARG117R, ARG64H, ASN125R, ASN59H, ASN65H, ASP113H, ASP139R, ASP63H, GLN127R, GLU103R, GLU109H, GLU109R, GLU110R, GLU121H, GLU121R, GLU126R, GLU129R, GLU131R, GLY66H, ILE101R, ILE124R, LEU104R, LEU107R, LEU120H, LEU120R, LYS112H, LYS135R, LYS136R, LYS95R, LYS99R, MET1H, PHE119H, PHE123R, SER115H, SER133R, SER98R, THR116H, TRP122H, TRP122R, TYR102R, TYR114H, TYR60H, TYR62H, TYR91R, VAL128R
• H-Z: ALA21H, ALA21Z, ALA26H, ALA26Z, ALA28H, ALA28Z, ALA29H, ALA29Z, ALA40H, ALA40Z, ALA45H, ALA45Z, ALA47H, ALA47Z, ALA54H, ALA54Z, ARG56H, ARG56Z, ARG67H, ARG67Z, ASN11H, ASN11Z, ASN15H, ASN15Z, ASN41H, ASN41Z, ASN59H, ASN59Z, ASN65H, ASN65Z, ASP33H, ASP33Z, ASP63H, ASP63Z, ASP71H, ASP71Z, GLU32H, GLU32Z, GLU37H, GLU37Z, GLU48H, GLU48Z, GLU49H, GLU49Z, GLU50H, GLU50Z, GLU69H, GLU69Z, GLU72H, GLU72Z, GLU79H, GLU79Z, GLY167H, GLY167Z, GLY35H, GLY35Z, GLY52H, GLY52Z, GLY66H, GLY66Z, HIS53Z, ILE51H, ILE51Z, ILE61H, ILE61Z, ILE73H, ILE73Z, LEU14H, LEU14Z, LEU165H, LEU165Z, LEU18H, LEU18Z, LEU23H, LEU23Z, LEU34H, LEU34Z, LEU55H, LEU55Z, LEU70H, LEU70Z, LEU7H, LEU7Z, LYS164H, LYS164Z, LYS44H, LYS44Z, LYS75H, LYS75Z, LYS78H, LYS78Z, MET27H, MET27Z, MET43H, MET43Z, PHE25H, PHE25Z, PHE31H, PHE31Z, PHE57H, PHE57Z, PRO163H, PRO163Z, PRO166H, PRO166Z, PRO74H, PRO74Z, PRO76H, PRO76Z, PRO77H, PRO77Z, TRP80H, TRP80Z, TYR19H, TYR19Z, TYR22H, TYR22Z, TYR24H, TYR24Z, TYR30H, TYR30Z, TYR58H, TYR58Z, TYR62H, TYR62Z, VAL68H, VAL68Z
• I-J: ALA105I, ALA106I, ALA108I, ALA118J, ALA132I, ARG117I, ARG117J, ARG64J, ASN125I, ASN59J, ASN65J, ASP113J, ASP139I, ASP63J, GLN127I, GLU103I, GLU109I, GLU109J, GLU121I, GLU121J, GLU126I, GLU129I, GLU130I, GLU131I, ILE101I, ILE124I, LEU104I, LEU107I, LEU120I, LEU120J, LEU138I, LEU2J, LYS112J, LYS135I, LYS136I, LYS142I, LYS95I, LYS99I, MET1J, PHE119J, SER115J, SER133I, SER98I, THR116J, TRP122I, TRP122J, TYR102I, TYR114J, TYR60J, TYR62J, TYR91I, VAL128I
• I-O: GLN149I, GLN149O, ILE150O, MET153I, MET153O, SER147I
• J-L: GLN149J, GLN149L, ILE150J, ILE150L, MET153J, MET153L, SER147J, SER147L
• J-Y: ALA144J, ASN41Y, ASP139J, ASP146J, ASP155J, ASP155Y, ASP33Y, GLN149J, GLN149Y, GLU157J, GLU32Y, GLU37Y, GLY35Y, GLY38Y, ILE150J, ILE150Y, LEU151J, LEU151Y, LEU154J, LEU154Y, LEU158J, LEU34Y, LEU36Y, LYS136J, LYS140J, LYS145J, LYS156J, LYS156Y, MET153J, MET153Y, PHE143J, PHE152J, PHE152Y, PHE39Y, PRO148J, PRO148Y, PRO83Y, SER147J, SER147Y
• K-Q: GLN149K, GLN149Q, ILE150Q, MET153K, MET153Q, PHE152K, SER147Q
• K-R: ALA105K, ALA106K, ALA108K, ALA118R, ALA132K, ARG117K, ARG117R, ARG64R, ASN125K, ASN59R, ASN65R, ASP113R, ASP139K, ASP63R, GLN127K, GLU103K, GLU109K, GLU109R, GLU110K, GLU121K, GLU121R, GLU126K, GLU129K, GLU130K, GLU131K, GLU94K, ILE101K, ILE124K, LEU104K, LEU107K, LEU120K, LEU120R, LYS112R, LYS135K, LYS136K, LYS142K, LYS95K, LYS99K, MET1R, PHE119R, PHE123K, SER115R, SER133K, SER98K, THR116R, TRP122K, TRP122R, TYR102K, TYR114R, TYR60R, TYR62R, TYR91K, VAL128K
• L-N: ALA105L, ALA106L, ALA108L, ALA118N, ALA132L, ARG117L, ARG117N, ARG64N, ASN125L, ASN59N, ASN65N, ASP113N, ASP139L, ASP63N, GLN127L, GLU103L, GLU109L, GLU109N, GLU110L, GLU121L, GLU121N, GLU126L, GLU129L, GLU130L, GLU131L, GLU94L, ILE101L, ILE124L, LEU104L, LEU107L, LEU120L, LEU120N, LYS112N, LYS135L, LYS136L, LYS95L, LYS99L, MET1N, PHE119N, SER115N, SER133L, SER98L, THR116N, TRP122L, TRP122N, TYR102L, TYR114N, TYR60N, TYR62N, TYR91L, VAL128L, VAL134L
• L-Q: ALA105Q, ALA106Q, ALA108Q, ALA118L, ALA132Q, ARG117L, ARG117Q, ARG64L, ASN125Q, ASN59L, ASN65L, ASP113L, ASP139Q, ASP63L, GLN127Q, GLU103Q, GLU109L, GLU109Q, GLU110Q, GLU121L, GLU121Q, GLU126Q, GLU129Q, GLU130Q, GLU131Q, GLU94Q, ILE101Q, ILE124Q, LEU104Q, LEU107Q, LEU120L, LEU120Q, LEU138Q, LYS112L, LYS135Q, LYS136Q, LYS142Q, LYS95Q, LYS99Q, MET1L, PHE119L, PHE123Q, SER115L, SER133Q, SER98Q, THR116L, TRP122L, TRP122Q, TYR102Q, TYR114L, TYR60L, TYR62L, TYR91Q, VAL128Q
• L-Y: ALA144Y, ASP139Y, ASP146Y, ASP155L, ASP155Y, ASP33L, GLN149L, GLN149Y, GLU157Y, GLU32L, GLU37L, GLY35L, GLY38L, ILE137Y, ILE150L, ILE150Y, LEU141Y, LEU151L, LEU151Y, LEU154Y, LEU158Y, LEU34L, LEU36L, LYS136Y, LYS140Y, LYS145Y, LYS156L, LYS156Y, MET153L, MET153Y, PHE143Y, PHE152L, PHE152Y, PHE39L, PRO148L, PRO148Y, PRO83L, SER147L, SER147Y
• M-N: GLN149M, GLN149N, ILE150M, ILE150N, MET153M, MET153N, PHE152N
• M-O: ALA105M, ALA106M, ALA108M, ALA118O, ALA132M, ARG117M, ARG117O, ARG64O, ASN125M, ASN59O, ASN65O, ASP113O, ASP139M, ASP63O, GLN127M, GLU103M, GLU109M, GLU109O, GLU110M, GLU121M, GLU121O, GLU126M, GLU129M, GLU130M, GLU131M, ILE101M, ILE124M, LEU104M, LEU107M, LEU120M, LEU120O, LYS112O, LYS135M, LYS136M, LYS142M, LYS95M, LYS99M, MET1O, PHE119O, PHE123M, SER115O, SER133M, SER98M, THR116O, TRP122M, TRP122O, TYR102M, TYR114O, TYR58O, TYR60O, TYR62O, TYR91M, VAL128M
• M-P: ALA105P, ALA106P, ALA108P, ALA118M, ALA132P, ARG117M, ARG117P, ARG64M, ASN125P, ASN59M, ASN65M, ASP113M, ASP139P, ASP63M, GLN127P, GLU103P, GLU109M, GLU109P, GLU110P, GLU121M, GLU121P, GLU126P, GLU129P, GLU130P, GLU131P, GLU94P, ILE101P, ILE124P, LEU104P, LEU107P, LEU120M, LEU120P, LEU138P, LYS112M, LYS135P, LYS136P, LYS142P, LYS95P, LYS99P, MET1M, PHE119M, PHE123P, SER115M, SER133P, SER98P, THR116M, TRP122M, TRP122P, TYR102P, TYR114M, TYR60M, TYR62M, TYR91P, VAL128P, VAL134P
• N-Q: ALA105N, ALA106N, ALA108N, ALA118Q, ALA132N, ARG117N, ARG117Q, ARG64Q, ASN125N, ASN59Q, ASN65Q, ASP113Q, ASP139N, ASP63Q, GLN127N, GLU103N, GLU109N, GLU109Q, GLU110N, GLU121N, GLU121Q, GLU126N, GLU129N, GLU130N, GLU131N, GLU94N, ILE101N, ILE124N, LEU104N, LEU107N, LEU120N, LEU120Q, LEU138N, LYS112Q, LYS135N, LYS136N, LYS142N, LYS95N, LYS99N, MET1Q, PHE119Q, SER115Q, SER133N, SER98N, THR116Q, TRP122N, TRP122Q, TYR102N, TYR114Q, TYR60Q, TYR62Q, TYR91N, VAL128N
• O-P: ALA105O, ALA106O, ALA118P, ALA132O, ARG117O, ARG117P, ARG64P, ASN125O, ASN59P, ASN65P, ASP113P, ASP139O, ASP63P, GLN127O, GLU103O, GLU109O, GLU109P, GLU110O, GLU121O, GLU121P, GLU126O, GLU129O, GLU130O, GLU131O, ILE101O, ILE124O, LEU104O, LEU107O, LEU120O, LEU120P, LEU138O, LYS112P, LYS135O, LYS136O, LYS142O, LYS95O, LYS99O, MET1P, PHE119P, SER115P, SER133O, SER98O, THR116P, TRP122O, TRP122P, TYR102O, TYR114P, TYR60P, TYR62P, TYR91O, VAL128O
• P-R: GLN149P, GLN149R, ILE150P, ILE150R, LYS156P, LYS156R, MET153P, MET153R, PHE152R, SER147P, SER147R
• P-Z: ALA144Z, ASP139Z, ASP146Z, ASP155P, ASP155Z, ASP33P, GLN149P, GLN149Z, GLU157Z, GLU32P, GLU37P, GLY35P, GLY38P, ILE150P, ILE150Z, LEU141Z, LEU151P, LEU151Z, LEU154Z, LEU158Z, LEU34P, LEU36P, LYS136Z, LYS140Z, LYS145Z, LYS156P, LYS156Z, MET153P, MET153Z, PHE143Z, PHE152P, PHE152Z, PHE39P, PRO148P, PRO148Z, PRO83P, SER147P, SER147Z
• R-Z: ALA132R, ALA144R, ASP139R, ASP146R, ASP155R, ASP155Z, ASP33Z, GLN149R, GLN149Z, GLU157R, GLU32Z, GLU37Z, GLY35Z, GLY38Z, ILE137R, ILE150R, ILE150Z, LEU141R, LEU151R, LEU151Z, LEU154R, LEU158R, LEU34Z, LEU36Z, LYS136R, LYS140R, LYS145R, LYS156R, LYS156Z, MET153R, MET153Z, PHE143R, PHE152R, PHE152Z, PRO148R, PRO148Z, PRO83Z, SER133R, SER147R, SER147Z
• S-W: ALA105W, ALA106W, ALA108W, ALA118S, ALA132W, ARG117S, ARG117W, ARG64S, ASN125W, ASN59S, ASN65S, ASP113S, ASP139W, ASP63S, GLN127W, GLU103W, GLU109S, GLU109W, GLU121S, GLU121W, GLU126W, GLU129W, GLU130W, GLU131W, ILE101W, ILE124W, LEU104W, LEU107W, LEU120S, LEU120W, LYS112S, LYS135W, LYS136W, LYS142W, LYS95W, LYS99W, MET1S, PHE119S, SER115S, SER133W, SER98W, THR116S, TRP122S, TRP122W, TYR102W, TYR114S, TYR60S, TYR62S, TYR91W, VAL128W
• S-X: ALA105S, ALA106S, ALA108S, ALA118X, ALA132S, ARG117S, ARG117X, ARG64X, ASN125S, ASN59X, ASN65X, ASP113X, ASP139S, ASP63X, GLN127S, GLU103S, GLU109S, GLU109X, GLU110S, GLU121S, GLU121X, GLU126S, GLU129S, GLU130S, GLU131S, ILE101S, ILE124S, LEU104S, LEU107S, LEU120S, LEU120X, LYS112X, LYS135S, LYS136S, LYS95S, LYS99S, MET1X, PHE119X, PHE123S, SER115X, SER133S, SER98S, THR116X, TRP122S, TRP122X, TYR102S, TYR114X, TYR60X, TYR62X, TYR91S, VAL128S
• T-U: ALA105U, ALA106U, ALA108U, ALA118T, ALA132U, ARG117T, ARG117U, ARG64T, ASN125U, ASN59T, ASN65T, ASP113T, ASP139U, ASP63T, GLN127U, GLU103U, GLU109T, GLU109U, GLU110U, GLU121T, GLU121U, GLU126U, GLU129U, GLU130U, GLU131U, GLU94U, ILE101U, ILE124U, LEU104U, LEU107U, LEU120T, LEU120U, LYS112T, LYS135U, LYS136U, LYS142U, LYS95U, LYS99U, MET1T, PHE119T, PHE123U, SER115T, SER133U, SER98U, THR116T, TRP122T, TRP122U, TYR102U, TYR114T, TYR60T, TYR62T, TYR91U, VAL128U, VAL134U
• U-W: GLN149U, GLN149W, ILE150U, ILE150W, LYS156U, LYS156W, MET153U, MET153W, PHE152W
• U-Y: GLU72Y, LYS75U, LYS78U
• W-X: ALA105X, ALA106X, ALA108X, ALA118W, ALA132X, ARG117W, ARG117X, ARG64W, ASN125X, ASN59W, ASN65W, ASP113W, ASP139X, ASP63W, GLN127X, GLU103X, GLU109W, GLU109X, GLU110X, GLU121W, GLU121X, GLU126X, GLU129X, GLU130X, GLU131X, GLU94X, ILE101X, ILE124X, LEU104X, LEU107X, LEU120W, LEU120X, LEU138X, LYS112W, LYS135X, LYS136X, LYS142X, LYS95X, LYS99X, MET1W, PHE119W, PHE123X, SER115W, SER133X, SER98X, THR116W, TRP122W, TRP122X, TYR102X, TYR114W, TYR60W, TYR62W, TYR91X, VAL128X