2JBM

qprtase structure from human

• Total interactions analyzed: 66
• Total true interactions: 33
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 241
  • Norm. En. per Res.: -4.393
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-203.8391	-162.9761	-691.896	-1058.7112	241	34	38	28201	14	67	62
A-C	-17.9781	-58.0524	-169.429	-245.4594	100	3	10	7261	4	24	25
A-D	-12.4258	0.0	-135.003	-147.4288	69	1	9	6666	0	4	4
A-E	0.0	14.4731	-14.0192	0.4539	14	0	0	660	0	5	2
A-F	-11.3237	0.0	-125.52	-136.8437	66	1	9	6347	0	4	4
B-C	-13.1961	0.0	-142.662	-155.8581	69	2	9	6863	0	4	4
B-D	0.0	15.8235	-15.0192	0.8043	14	0	0	661	0	4	2
B-E	-11.5547	0.0	-135.488	-147.0427	67	2	9	6588	0	4	4
B-F	-15.5972	-60.2081	-139.044	-214.8493	92	3	10	6519	4	22	25
C-D	-169.7319	-145.6303	-665.34	-980.7021	235	30	37	27177	14	62	59
C-E	-10.8146	0.0	-130.483	-141.2976	69	1	9	6462	0	4	4
C-F	0.0	14.4614	-12.4094	2.052	12	0	0	617	0	4	2
D-E	-15.5812	-59.6313	-133.97	-209.1824	92	4	10	6534	6	23	25
D-F	-12.1312	0.0	-127.118	-139.2492	66	1	9	6359	0	4	4
E-F	-193.6349	-148.8663	-689.273	-1031.7742	239	34	39	27966	14	65	61
F-H	0.0	0.0	-0.0357	-0.0357	3	0	0	14	0	0	0
F-I	-17.3777	0.0	-73.8143	-91.192	44	10	1	3535	0	9	10
F-J	0.0	0.0	-0.013	-0.013	2	0	0	7	0	0	0
G-H	-188.1377	-144.5853	-665.78	-998.503	236	41	39	27402	14	62	58
G-I	-17.1312	-57.0455	-152.035	-226.2117	92	2	10	6632	4	23	25
G-J	-12.8906	0.0	-137.22	-150.1106	69	1	9	6619	0	4	4
G-K	0.0	15.6713	-15.0839	0.5874	14	0	0	656	0	4	2
G-L	-12.0279	0.0	-125.663	-137.6909	68	1	9	6339	0	4	4
H-I	-12.3306	0.0	-130.582	-142.9126	68	1	9	6479	0	4	4
H-J	0.0	15.1011	-14.0484	1.0527	14	0	0	651	0	4	2
H-K	-13.5287	0.0	-134.88	-148.4087	68	2	9	6584	0	4	3
H-L	-17.2055	-53.4292	-137.861	-208.4957	91	2	9	6352	4	23	24
I-J	-168.0177	-153.8368	-679.262	-1001.1164	234	30	38	27562	12	65	61
I-K	-11.4148	0.0	-128.408	-139.8228	68	1	9	6388	0	4	4
I-L	0.0	14.2521	-12.5172	1.7349	12	0	0	625	0	4	2
J-K	-13.9215	-55.8801	-149.65	-219.4516	96	4	10	6749	4	24	25
J-L	-11.5154	0.0	-135.44	-146.9554	70	2	9	6603	0	4	4
K-L	-195.9495	-152.5615	-682.999	-1031.51	236	34	39	27568	13	61	57

Interface residues

• A-B: ALA106A, ALA106B, ALA111A, ALA111B, ALA179A, ALA179B, ALA180A, ALA180B, ALA186A, ALA186B, ALA189A, ALA189B, ALA190A, ALA190B, ALA193A, ALA193B, ALA194A, ALA194B, ALA197A, ALA197B, ALA277A, ALA277B, ALA278A, ALA278B, ALA280A, ALA280B, ALA289A, ALA289B, ALA35A, ALA35B, ALA36A, ALA36B, ALA41A, ALA41B, ALA46A, ALA46B, ALA47A, ALA47B, ALA96A, ALA96B, ARG104A, ARG104B, ARG112A, ARG112B, ARG140A, ARG140B, ARG147A, ARG147B, ARG163A, ARG163B, ARG188A, ARG188B, ARG191A, ARG191B, ARG26A, ARG26B, ASN108A, ASN108B, ASN175A, ASN175B, ASN225A, ASN225B, ASN33A, ASN33B, ASP165A, ASP165B, ASP174A, ASP174B, ASP195A, ASP195B, ASP224A, ASP224B, ASP282A, ASP282B, ASP28A, ASP28B, CYS113A, CYS113B, CYS29A, CYS29B, GLN192A, GLN192B, GLN276A, GLN276B, GLN45A, GLN45B, GLU103A, GLU103B, GLU150A, GLU150B, GLU203A, GLU203B, GLU27A, GLU27B, GLU291B, GLY102A, GLY102B, GLY115A, GLY115B, GLY145A, GLY145B, GLY167A, GLY167B, GLY168A, GLY168B, GLY181A, GLY181B, GLY182A, GLY182B, GLY252A, GLY252B, GLY272A, GLY272B, GLY31A, GLY31B, GLY40A, GLY40B, GLY42A, GLY42B, HIS176A, HIS176B, HIS97A, HIS97B, ILE116A, ILE116B, ILE65A, ILE65B, LEU100A, LEU100B, LEU101A, LEU101B, LEU107A, LEU107B, LEU110A, LEU110B, LEU148A, LEU148B, LEU166A, LEU166B, LEU169A, LEU169B, LEU198A, LEU198B, LEU20A, LEU20B, LEU25A, LEU25B, LEU274A, LEU274B, LEU281A, LEU281B, LEU285A, LEU285B, LEU287A, LEU287B, LEU32A, LEU32B, LEU37A, LEU37B, LEU99A, LEU99B, LYS141A, LYS141B, LYS173A, LYS173B, LYS185A, LYS185B, LYS286A, LYS286B, LYS290A, LYS290B, LYS51A, LYS51B, MET171A, MET171B, MET273A, MET273B, PHE146A, PHE146B, PHE283A, PHE283B, PHE288A, PHE288B, PHE61A, PHE61B, PRO144A, PRO144B, PRO279A, PRO279B, PRO30A, PRO30B, SER205A, SER205B, SER23A, SER23B, SER284A, SER284B, SER39A, SER39B, SER44A, SER44B, THR109A, THR109B, THR139A, THR139B, THR142A, THR142B, THR143A, THR143B, THR275A, THR275B, TRP24A, TRP24B, TYR164A, TYR164B, TYR34A, TYR34B, VAL105A, VAL105B, VAL149A, VAL149B, VAL170A, VAL170B, VAL172A, VAL172B, VAL177A, VAL177B, VAL178A, VAL178B, VAL183A, VAL183B, VAL187A, VAL187B, VAL200A, VAL200B, VAL202A, VAL202B, VAL21A, VAL21B, VAL38A, VAL38B
• A-C: ALA137A, ALA137C, ALA159A, ALA159C, ALA160A, ALA160C, ALA189A, ALA189C, ALA190C, ALA193A, ALA193C, ALA194A, ALA194C, ALA197A, ALA197C, ALA246A, ALA246C, ARG163A, ARG163C, ARG188A, ARG188C, ARG191A, ARG191C, ASP165A, ASP165C, ASP195A, ASP195C, ASP219A, ASP219C, ASP267A, ASP267C, ASP4A, ASP4C, GLN192A, GLN192C, GLU201A, GLU201C, GLU248A, GLU248C, GLY134A, GLY134C, GLY158A, GLY167A, GLY167C, GLY168A, GLY168C, HIS135A, HIS135C, HIS162A, HIS162C, ILE266A, ILE266C, ILE269A, ILE269C, LEU11A, LEU11C, LEU155A, LEU155C, LEU166A, LEU166C, LEU169A, LEU169C, LEU198A, LEU198C, LEU220A, LEU220C, LEU8A, LEU8C, LYS199A, LYS199C, LYS239A, LYS239C, MET3A, MET3C, PHE196A, PHE196C, PRO13A, PRO13C, SER161A, SER161C, SER244A, SER244C, THR133A, THR133C, TRP132A, TRP132C, TYR164A, TYR164C, VAL136A, VAL136C, VAL170A, VAL170C, VAL200A, VAL200C, VAL245A, VAL245C, VAL247A, VAL247C, VAL268A, VAL268C
• A-D: ALA18A, ALA18D, ALA19A, ALA19D, ALA35D, ALA36D, ALA41D, ALA5A, ALA64D, ALA96D, ALA9A, ARG147A, ARG163A, ARG26D, ASN33D, ASN70D, ASP165A, ASP22D, ASP4A, CYS29D, CYS98D, GLN68D, GLU150A, GLU6A, GLY145A, GLY153A, GLY167A, GLY168A, GLY31D, GLY40D, GLY42D, GLY7A, HIS162A, HIS97D, ILE65D, LEU101D, LEU10A, LEU11A, LEU12A, LEU148A, LEU154A, LEU155A, LEU17A, LEU20A, LEU25D, LEU32D, LEU37D, LEU69D, LEU8A, LYS151A, MET3A, PHE61A, PRO13A, PRO14A, PRO30D, PRO95D, SER161A, SER23D, SER39D, THR16A, THR67D, TRP24D, TYR152A, TYR164A, TYR34D, VAL149A, VAL15A, VAL21D, VAL38D
• A-E: ARG26A, ARG26E, ASP22A, ASP22E, CYS29A, CYS29E, GLU27A, GLU27E, GLY31A, GLY31E, PRO30A, PRO30E, SER23A, SER23E
• A-F: ALA18A, ALA18F, ALA19A, ALA19F, ALA35A, ALA36A, ALA41A, ALA64A, ALA96A, ALA9F, ARG147F, ARG163F, ARG26A, ASN33A, ASN70A, ASP165F, ASP22A, ASP4F, CYS29A, CYS98A, GLN68A, GLU150F, GLY145F, GLY153F, GLY167F, GLY168F, GLY31A, GLY40A, GLY42A, GLY7F, HIS162F, HIS97A, ILE65A, LEU101A, LEU10F, LEU11F, LEU12F, LEU148F, LEU154F, LEU155F, LEU17F, LEU20F, LEU25A, LEU32A, LEU37A, LEU69A, LEU8F, LYS151F, PHE61F, PRO13F, PRO14F, PRO30A, PRO95A, SER161F, SER23A, SER39A, THR16F, THR67A, TRP24A, TYR152F, TYR164F, TYR34A, VAL149F, VAL15F, VAL21A, VAL38A
• B-C: ALA18B, ALA18C, ALA19B, ALA19C, ALA35B, ALA36B, ALA41B, ALA5C, ALA64B, ALA96B, ALA9C, ARG147C, ARG163C, ARG26B, ASN33B, ASN70B, ASP165C, ASP22B, ASP4C, CYS29B, CYS98B, GLN68B, GLU150C, GLU6C, GLY153C, GLY167C, GLY168C, GLY31B, GLY40B, GLY42B, GLY7C, HIS162C, HIS97B, ILE65B, LEU101B, LEU10C, LEU11C, LEU12C, LEU148C, LEU154C, LEU155C, LEU17C, LEU20C, LEU25B, LEU32B, LEU37B, LEU69B, LEU8C, LYS151C, LYS290B, MET3C, PHE61C, PRO13C, PRO14C, PRO30B, PRO95B, SER161C, SER23B, SER39B, THR16C, THR67B, TRP24B, TYR152C, TYR164C, TYR34B, VAL149C, VAL15C, VAL21B, VAL38B
• B-D: ARG26B, ARG26D, ASP22B, ASP22D, CYS29B, CYS29D, GLU27B, GLU27D, GLY31B, GLY31D, PRO30B, PRO30D, SER23B, SER23D
• B-E: ALA18B, ALA18E, ALA19B, ALA19E, ALA35E, ALA36E, ALA41E, ALA64E, ALA96E, ALA9B, ARG147B, ARG163B, ARG26E, ASN33E, ASN70E, ASP165B, ASP22E, ASP4B, CYS29E, CYS98E, GLN68E, GLU150B, GLU6B, GLY145B, GLY153B, GLY167B, GLY168B, GLY31E, GLY40E, GLY42E, GLY7B, HIS162B, HIS97E, ILE65E, LEU101E, LEU10B, LEU11B, LEU12B, LEU148B, LEU154B, LEU155B, LEU17B, LEU20B, LEU25E, LEU32E, LEU37E, LEU69E, LEU8B, LYS151B, PHE61B, PRO13B, PRO14B, PRO30E, PRO95E, SER161B, SER23E, SER39E, THR16B, THR67E, TRP24E, TYR152B, TYR164B, TYR34E, VAL149B, VAL15B, VAL21E, VAL38E
• B-F: ALA137B, ALA137F, ALA159B, ALA159F, ALA160B, ALA160F, ALA193B, ALA193F, ALA194B, ALA194F, ALA197B, ALA197F, ALA246B, ALA246F, ARG163B, ARG163F, ARG191B, ARG191F, ASP165B, ASP165F, ASP195B, ASP195F, ASP219B, ASP219F, ASP267B, ASP267F, ASP4B, ASP4F, GLN192B, GLN192F, GLU201B, GLU201F, GLU248B, GLU248F, GLY134B, GLY134F, GLY167B, GLY167F, GLY168B, GLY168F, HIS135B, HIS135F, HIS162B, HIS162F, ILE266B, ILE266F, ILE269B, ILE269F, LEU11B, LEU11F, LEU155B, LEU155F, LEU166B, LEU166F, LEU169B, LEU169F, LEU198B, LEU198F, LEU220B, LEU220F, LEU8B, LEU8F, LYS199B, LYS199F, LYS239B, LYS239F, PHE196B, PHE196F, PRO13B, PRO13F, SER161B, SER161F, SER244B, SER244F, THR133B, THR133F, TRP132B, TRP132F, TYR164B, TYR164F, VAL136B, VAL136F, VAL170B, VAL170F, VAL200B, VAL200F, VAL245B, VAL245F, VAL247B, VAL247F, VAL268B, VAL268F
• C-D: ALA106C, ALA106D, ALA111C, ALA111D, ALA179C, ALA179D, ALA180C, ALA180D, ALA186C, ALA186D, ALA189C, ALA189D, ALA190C, ALA190D, ALA193C, ALA193D, ALA194C, ALA194D, ALA197C, ALA197D, ALA277C, ALA277D, ALA278C, ALA278D, ALA280C, ALA280D, ALA35C, ALA35D, ALA36C, ALA36D, ALA41C, ALA41D, ALA46C, ALA46D, ALA47C, ALA47D, ALA96C, ALA96D, ARG104C, ARG104D, ARG112C, ARG112D, ARG140C, ARG140D, ARG147C, ARG147D, ARG163C, ARG163D, ARG188C, ARG188D, ARG191C, ARG191D, ARG26C, ARG26D, ASN108C, ASN108D, ASN175C, ASN175D, ASN225C, ASN225D, ASN33C, ASN33D, ASP165C, ASP165D, ASP174C, ASP174D, ASP195C, ASP195D, ASP224D, ASP282C, ASP282D, ASP28C, ASP28D, CYS113C, CYS113D, CYS29C, CYS29D, GLN192C, GLN192D, GLN276C, GLN276D, GLN45C, GLN45D, GLU103C, GLU103D, GLU150C, GLU150D, GLU203C, GLU203D, GLU27C, GLU27D, GLY102C, GLY102D, GLY115C, GLY115D, GLY145C, GLY145D, GLY167C, GLY167D, GLY168C, GLY168D, GLY181C, GLY181D, GLY182C, GLY182D, GLY252C, GLY252D, GLY272C, GLY272D, GLY31C, GLY31D, GLY40C, GLY40D, GLY42C, GLY42D, HIS176C, HIS176D, HIS97C, HIS97D, ILE116C, ILE116D, ILE65C, ILE65D, LEU100C, LEU100D, LEU101C, LEU101D, LEU107C, LEU107D, LEU110C, LEU110D, LEU148C, LEU148D, LEU166C, LEU166D, LEU169C, LEU169D, LEU198C, LEU198D, LEU20C, LEU20D, LEU25C, LEU25D, LEU274C, LEU274D, LEU281C, LEU281D, LEU285C, LEU285D, LEU287C, LEU287D, LEU32C, LEU32D, LEU37C, LEU37D, LEU99C, LEU99D, LYS141C, LYS141D, LYS173C, LYS173D, LYS185C, LYS185D, LYS286C, LYS286D, LYS51C, LYS51D, MET171C, MET171D, MET273C, MET273D, PHE146C, PHE146D, PHE283C, PHE283D, PHE288C, PHE288D, PHE61C, PHE61D, PRO144C, PRO144D, PRO279C, PRO279D, PRO30C, PRO30D, SER205C, SER205D, SER23C, SER23D, SER284C, SER284D, SER39C, SER39D, SER44C, SER44D, THR109C, THR109D, THR139C, THR139D, THR142C, THR142D, THR143C, THR143D, THR275C, THR275D, TRP24C, TRP24D, TYR164C, TYR164D, TYR34C, TYR34D, VAL105C, VAL105D, VAL149C, VAL149D, VAL170C, VAL170D, VAL172C, VAL172D, VAL177C, VAL177D, VAL178C, VAL178D, VAL183C, VAL183D, VAL187C, VAL187D, VAL200C, VAL200D, VAL202C, VAL202D, VAL21C, VAL21D, VAL38C, VAL38D
• C-E: ALA18C, ALA18E, ALA19C, ALA19E, ALA35C, ALA36C, ALA41C, ALA5E, ALA64C, ALA96C, ALA9E, ARG147E, ARG163E, ARG26C, ASN33C, ASN70C, ASP165E, ASP22C, ASP4E, CYS29C, CYS98C, GLN68C, GLU150E, GLU6E, GLY145E, GLY153E, GLY167E, GLY168E, GLY31C, GLY40C, GLY42C, GLY7E, HIS162E, HIS97C, ILE65C, LEU101C, LEU10E, LEU11E, LEU12E, LEU148E, LEU154E, LEU155E, LEU169E, LEU17E, LEU20E, LEU25C, LEU32C, LEU37C, LEU69C, LEU8E, LYS151E, PHE61E, PRO13E, PRO14E, PRO30C, PRO95C, SER161E, SER23C, SER39C, THR16E, THR67C, TRP24C, TYR152E, TYR164E, TYR34C, VAL149E, VAL15E, VAL21C, VAL38C
• C-F: ARG26C, ARG26F, CYS29C, CYS29F, GLU27C, GLU27F, GLY31C, GLY31F, PRO30C, PRO30F, SER23C, SER23F
• D-E: ALA137D, ALA137E, ALA159D, ALA159E, ALA160D, ALA160E, ALA193D, ALA193E, ALA194D, ALA194E, ALA197D, ALA197E, ALA246D, ALA246E, ARG163D, ARG163E, ARG191D, ARG191E, ASP165D, ASP165E, ASP195D, ASP195E, ASP219D, ASP219E, ASP267D, ASP267E, ASP4D, ASP4E, GLN192D, GLN192E, GLU201D, GLU201E, GLU248D, GLU248E, GLY134D, GLY134E, GLY167D, GLY167E, GLY168D, GLY168E, HIS135D, HIS135E, HIS162D, HIS162E, ILE266D, ILE266E, ILE269D, ILE269E, LEU11D, LEU11E, LEU155D, LEU155E, LEU166D, LEU166E, LEU169D, LEU169E, LEU198D, LEU198E, LEU220D, LEU220E, LEU8D, LEU8E, LYS199D, LYS199E, LYS239D, LYS239E, PHE196D, PHE196E, PRO13D, PRO13E, SER161D, SER161E, SER244D, SER244E, THR133D, THR133E, TRP132D, TRP132E, TYR164D, TYR164E, VAL136D, VAL136E, VAL170D, VAL170E, VAL200D, VAL200E, VAL245D, VAL245E, VAL247D, VAL247E, VAL268D, VAL268E
• D-F: ALA18D, ALA18F, ALA19D, ALA19F, ALA35F, ALA36F, ALA41F, ALA64F, ALA96F, ALA9D, ARG147D, ARG163D, ARG26F, ASN33F, ASN70F, ASP165D, ASP22F, ASP4D, CYS29F, CYS98F, GLN68F, GLU150D, GLU6D, GLY153D, GLY167D, GLY168D, GLY31F, GLY40F, GLY42F, GLY7D, HIS162D, HIS97F, ILE65F, LEU101F, LEU10D, LEU11D, LEU12D, LEU148D, LEU154D, LEU155D, LEU17D, LEU20D, LEU25F, LEU32F, LEU37F, LEU69F, LEU8D, LYS151D, PHE61D, PRO13D, PRO14D, PRO30F, PRO95F, SER161D, SER23F, SER39F, THR16D, THR67F, TRP24F, TYR152D, TYR164D, TYR34F, VAL149D, VAL15D, VAL21F, VAL38F
• E-F: ALA106E, ALA106F, ALA111E, ALA111F, ALA179E, ALA179F, ALA180E, ALA180F, ALA186E, ALA186F, ALA189E, ALA189F, ALA190E, ALA190F, ALA193E, ALA193F, ALA194E, ALA194F, ALA197E, ALA197F, ALA277E, ALA277F, ALA278E, ALA278F, ALA280E, ALA280F, ALA289E, ALA35E, ALA35F, ALA36E, ALA36F, ALA41E, ALA41F, ALA46E, ALA46F, ALA47E, ALA47F, ALA96E, ALA96F, ARG104E, ARG104F, ARG112E, ARG112F, ARG140E, ARG140F, ARG147E, ARG147F, ARG163E, ARG163F, ARG188E, ARG188F, ARG191E, ARG191F, ARG26E, ARG26F, ASN108E, ASN108F, ASN175E, ASN175F, ASN225E, ASN225F, ASN33E, ASN33F, ASP165E, ASP165F, ASP174E, ASP174F, ASP195E, ASP195F, ASP224E, ASP224F, ASP282E, ASP282F, ASP28E, ASP28F, CYS113E, CYS113F, CYS29E, CYS29F, GLN192E, GLN192F, GLN276E, GLN276F, GLN45E, GLN45F, GLU103E, GLU103F, GLU150E, GLU150F, GLU203E, GLU203F, GLU27E, GLU27F, GLU291E, GLY102E, GLY102F, GLY115E, GLY115F, GLY145E, GLY145F, GLY167E, GLY167F, GLY168E, GLY168F, GLY181E, GLY181F, GLY182E, GLY182F, GLY252E, GLY252F, GLY272E, GLY272F, GLY31E, GLY31F, GLY40E, GLY40F, GLY42E, GLY42F, HIS176E, HIS176F, HIS97E, HIS97F, ILE116E, ILE116F, ILE65E, ILE65F, LEU100E, LEU100F, LEU101E, LEU101F, LEU107E, LEU107F, LEU110E, LEU110F, LEU148E, LEU148F, LEU166E, LEU166F, LEU169E, LEU169F, LEU198E, LEU198F, LEU20E, LEU20F, LEU25E, LEU25F, LEU274E, LEU274F, LEU281E, LEU281F, LEU285E, LEU285F, LEU287E, LEU287F, LEU32E, LEU32F, LEU37E, LEU37F, LEU99E, LEU99F, LYS141E, LYS141F, LYS173E, LYS173F, LYS185E, LYS185F, LYS286E, LYS286F, LYS290E, LYS51E, LYS51F, MET171E, MET171F, MET273E, MET273F, PHE146E, PHE146F, PHE283E, PHE283F, PHE288E, PHE288F, PHE61E, PHE61F, PRO144E, PRO144F, PRO279E, PRO279F, PRO30E, PRO30F, SER205E, SER205F, SER23E, SER23F, SER284E, SER284F, SER39E, SER39F, SER44E, SER44F, THR109E, THR109F, THR139E, THR139F, THR142E, THR142F, THR143E, THR143F, THR275E, THR275F, TRP24E, TRP24F, TYR164E, TYR164F, TYR34E, TYR34F, VAL105E, VAL105F, VAL149E, VAL149F, VAL170E, VAL170F, VAL172E, VAL172F, VAL177E, VAL177F, VAL178E, VAL178F, VAL183E, VAL183F, VAL187E, VAL187F, VAL200E, VAL200F, VAL202E, VAL202F, VAL21E, VAL21F, VAL38E, VAL38F
• F-H: ARG128F, GLY129F, PRO43H
• F-I: ALA289I, ALA47F, ALA47I, ALA50F, ALA87F, ALA90F, ALA90I, ARG88F, ARG88I, ARG93I, ASP4F, GLN45I, GLN72I, GLU291I, GLU6F, GLU91F, GLU91I, LEU287I, LEU48F, LEU77F, LEU77I, LEU83F, LYS290I, LYS82F, PHE288I, PHE76F, PHE76I, PRO43I, PRO53F, PRO78F, PRO78I, PRO85F, SER44I, SER74F, SER74I, SER81F, TRP49F, TRP49I, TRP75F, TRP75I, VAL84F, VAL86F, VAL89F, VAL89I
• F-J: ARG88F, VAL178J
• G-H: ALA106G, ALA106H, ALA111G, ALA111H, ALA179G, ALA179H, ALA180G, ALA180H, ALA186G, ALA186H, ALA189G, ALA189H, ALA190G, ALA190H, ALA193G, ALA193H, ALA194G, ALA194H, ALA197G, ALA197H, ALA277G, ALA277H, ALA278G, ALA278H, ALA280G, ALA280H, ALA35G, ALA35H, ALA36G, ALA36H, ALA41G, ALA41H, ALA46G, ALA46H, ALA47G, ALA47H, ALA96G, ALA96H, ARG104G, ARG104H, ARG112G, ARG112H, ARG140G, ARG140H, ARG147G, ARG147H, ARG163G, ARG163H, ARG188G, ARG188H, ARG191G, ARG191H, ARG26G, ARG26H, ASN108G, ASN108H, ASN175G, ASN175H, ASN225G, ASN225H, ASN33G, ASN33H, ASP165G, ASP165H, ASP174G, ASP174H, ASP195G, ASP195H, ASP224G, ASP224H, ASP282G, ASP282H, ASP28G, ASP28H, CYS113G, CYS113H, CYS29G, CYS29H, GLN192G, GLN192H, GLN276G, GLN276H, GLN45G, GLN45H, GLU103G, GLU103H, GLU150G, GLU150H, GLU203G, GLU203H, GLU27G, GLU27H, GLY102G, GLY102H, GLY115G, GLY115H, GLY145G, GLY145H, GLY167G, GLY167H, GLY168G, GLY168H, GLY181G, GLY181H, GLY182G, GLY182H, GLY252G, GLY252H, GLY272G, GLY272H, GLY31G, GLY31H, GLY40G, GLY40H, GLY42G, GLY42H, HIS176G, HIS176H, HIS97G, HIS97H, ILE116G, ILE116H, ILE65G, ILE65H, LEU100G, LEU100H, LEU101G, LEU101H, LEU107G, LEU107H, LEU110G, LEU110H, LEU148G, LEU148H, LEU166G, LEU166H, LEU169G, LEU169H, LEU198G, LEU198H, LEU20G, LEU20H, LEU25G, LEU25H, LEU274G, LEU274H, LEU281G, LEU281H, LEU285G, LEU285H, LEU287G, LEU287H, LEU32G, LEU32H, LEU37G, LEU37H, LEU99G, LEU99H, LYS141G, LYS141H, LYS173G, LYS173H, LYS185G, LYS185H, LYS286G, LYS286H, LYS51G, LYS51H, MET171G, MET171H, MET273G, MET273H, PHE146G, PHE146H, PHE283G, PHE283H, PHE288G, PHE288H, PHE61G, PHE61H, PRO144G, PRO144H, PRO279G, PRO279H, PRO30G, PRO30H, SER205G, SER205H, SER23G, SER23H, SER284G, SER284H, SER39G, SER39H, SER44G, SER44H, THR109G, THR109H, THR139G, THR139H, THR142G, THR142H, THR143G, THR143H, THR275G, THR275H, TRP24G, TRP24H, TYR164G, TYR164H, TYR34G, TYR34H, VAL105G, VAL105H, VAL149G, VAL149H, VAL170G, VAL170H, VAL172G, VAL172H, VAL177G, VAL177H, VAL178G, VAL178H, VAL183G, VAL183H, VAL187G, VAL187H, VAL200G, VAL200H, VAL202G, VAL202H, VAL21G, VAL21H, VAL38G, VAL38H
• G-I: ALA137G, ALA137I, ALA159G, ALA159I, ALA160G, ALA160I, ALA193G, ALA193I, ALA194G, ALA194I, ALA197G, ALA197I, ALA246G, ALA246I, ARG163G, ARG163I, ARG191G, ARG191I, ASP165G, ASP165I, ASP195G, ASP195I, ASP219G, ASP219I, ASP267G, ASP267I, ASP4G, ASP4I, GLN192G, GLN192I, GLU201G, GLU201I, GLU248G, GLU248I, GLY134G, GLY134I, GLY167G, GLY167I, GLY168G, GLY168I, HIS135G, HIS135I, HIS162G, HIS162I, ILE266G, ILE266I, ILE269G, ILE269I, LEU11G, LEU11I, LEU155G, LEU155I, LEU166G, LEU166I, LEU169G, LEU169I, LEU198G, LEU198I, LEU220G, LEU220I, LEU8G, LEU8I, LYS199G, LYS199I, LYS239G, LYS239I, PHE196G, PHE196I, PRO13G, PRO13I, SER161G, SER161I, SER244G, SER244I, THR133G, THR133I, TRP132G, TRP132I, TYR164G, TYR164I, VAL136G, VAL136I, VAL170G, VAL170I, VAL200G, VAL200I, VAL245G, VAL245I, VAL247G, VAL247I, VAL268G, VAL268I
• G-J: ALA18G, ALA18J, ALA19G, ALA19J, ALA35J, ALA36J, ALA41J, ALA5G, ALA64J, ALA96J, ALA9G, ARG147G, ARG163G, ARG26J, ASN33J, ASN70J, ASP165G, ASP22J, ASP4G, CYS29J, CYS98J, GLN68J, GLU150G, GLU6G, GLY145G, GLY153G, GLY167G, GLY168G, GLY31J, GLY40J, GLY42J, GLY7G, HIS162G, HIS97J, ILE65J, LEU101J, LEU10G, LEU11G, LEU12G, LEU148G, LEU154G, LEU155G, LEU17G, LEU20G, LEU25J, LEU32J, LEU37J, LEU69J, LEU8G, LYS151G, PHE61G, PRO13G, PRO14G, PRO30J, PRO95J, SER161G, SER23J, SER39J, THR16G, THR67G, THR67J, TRP24J, TYR152G, TYR164G, TYR34J, VAL149G, VAL15G, VAL21J, VAL38J
• G-K: ARG26G, ARG26K, ASP22G, ASP22K, CYS29G, CYS29K, GLU27G, GLU27K, GLY31G, GLY31K, PRO30G, PRO30K, SER23G, SER23K
• G-L: ALA18G, ALA18L, ALA19G, ALA19L, ALA35G, ALA36G, ALA41G, ALA5L, ALA64G, ALA96G, ALA9L, ARG147L, ARG163L, ARG26G, ASN33G, ASN70G, ASP165L, ASP22G, ASP4L, CYS29G, CYS98G, GLN68G, GLU150L, GLU6L, GLY145L, GLY153L, GLY167L, GLY168L, GLY31G, GLY40G, GLY42G, GLY7L, HIS162L, HIS97G, ILE65G, LEU101G, LEU10L, LEU11L, LEU12L, LEU148L, LEU154L, LEU155L, LEU17L, LEU20L, LEU25G, LEU32G, LEU37G, LEU69G, LEU8L, LYS151L, PHE61L, PRO13L, PRO14L, PRO30G, PRO95G, SER161L, SER23G, SER39G, THR16L, THR67G, TRP24G, TYR152L, TYR164L, TYR34G, VAL149L, VAL15L, VAL21G, VAL38G
• H-I: ALA18H, ALA18I, ALA19H, ALA19I, ALA35H, ALA36H, ALA41H, ALA5I, ALA64H, ALA96H, ALA9I, ARG147I, ARG163I, ARG26H, ASN33H, ASN70H, ASP165I, ASP22H, ASP4I, CYS29H, CYS71H, CYS98H, GLN68H, GLU150I, GLU6I, GLY153I, GLY167I, GLY168I, GLY31H, GLY40H, GLY42H, GLY7I, HIS162I, HIS97H, ILE65H, LEU101H, LEU10I, LEU11I, LEU12I, LEU148I, LEU154I, LEU155I, LEU17I, LEU20I, LEU25H, LEU32H, LEU37H, LEU69H, LEU8I, LYS151I, PHE61I, PRO13I, PRO14I, PRO30H, PRO95H, SER161I, SER23H, SER39H, THR16I, THR67H, TRP24H, TYR152I, TYR164I, TYR34H, VAL149I, VAL15I, VAL21H, VAL38H
• H-J: ARG26H, ARG26J, ASP22H, ASP22J, CYS29H, CYS29J, GLU27H, GLU27J, GLY31H, GLY31J, PRO30H, PRO30J, SER23H, SER23J
• H-K: ALA18H, ALA18K, ALA19H, ALA19K, ALA35K, ALA36K, ALA41K, ALA5H, ALA64K, ALA96K, ALA9H, ARG147H, ARG163H, ARG26K, ASN33K, ASN70K, ASP165H, ASP22K, ASP4H, CYS29K, CYS98K, GLN68K, GLU150H, GLU6H, GLY145H, GLY153H, GLY167H, GLY168H, GLY31K, GLY40K, GLY42K, GLY7H, HIS162H, HIS97K, ILE65K, LEU101K, LEU10H, LEU11H, LEU12H, LEU148H, LEU154H, LEU155H, LEU17H, LEU20H, LEU25K, LEU32K, LEU37K, LEU69K, LEU8H, LYS151H, PHE61H, PRO13H, PRO14H, PRO30K, PRO95K, SER161H, SER23K, SER39K, THR16H, THR67K, TRP24K, TYR152H, TYR164H, TYR34K, VAL149H, VAL15H, VAL21K, VAL38K
• H-L: ALA137H, ALA137L, ALA159H, ALA159L, ALA160H, ALA160L, ALA193H, ALA193L, ALA194H, ALA194L, ALA197H, ALA197L, ALA246H, ALA246L, ARG163H, ARG163L, ARG191H, ARG191L, ASP165H, ASP165L, ASP195H, ASP195L, ASP219H, ASP219L, ASP267H, ASP267L, ASP4H, ASP4L, GLN192H, GLN192L, GLU201H, GLU201L, GLU248H, GLU248L, GLY134H, GLY134L, GLY167H, GLY167L, GLY168H, GLY168L, HIS135H, HIS135L, HIS162H, HIS162L, ILE266H, ILE266L, ILE269H, LEU11H, LEU11L, LEU155H, LEU155L, LEU166H, LEU166L, LEU169H, LEU169L, LEU198H, LEU198L, LEU220H, LEU220L, LEU8H, LEU8L, LYS199H, LYS199L, LYS239H, LYS239L, PHE196H, PHE196L, PRO13H, PRO13L, SER161H, SER161L, SER244H, SER244L, THR133H, THR133L, TRP132H, TRP132L, TYR164H, TYR164L, VAL136H, VAL136L, VAL170H, VAL170L, VAL200H, VAL200L, VAL245H, VAL245L, VAL247H, VAL247L, VAL268H, VAL268L
• I-J: ALA106I, ALA106J, ALA111I, ALA111J, ALA179I, ALA179J, ALA180I, ALA180J, ALA186I, ALA186J, ALA189I, ALA189J, ALA190I, ALA190J, ALA193I, ALA193J, ALA194I, ALA194J, ALA197I, ALA197J, ALA277I, ALA277J, ALA278I, ALA278J, ALA280I, ALA280J, ALA289I, ALA35I, ALA35J, ALA36I, ALA36J, ALA41I, ALA41J, ALA46I, ALA46J, ALA47I, ALA47J, ALA96I, ALA96J, ARG104I, ARG104J, ARG112I, ARG112J, ARG140I, ARG140J, ARG147I, ARG147J, ARG163I, ARG163J, ARG188I, ARG188J, ARG191I, ARG191J, ARG26I, ARG26J, ASN108I, ASN108J, ASN175I, ASN175J, ASN225I, ASN225J, ASN33I, ASN33J, ASP165I, ASP165J, ASP174I, ASP174J, ASP195I, ASP195J, ASP282I, ASP282J, ASP28I, ASP28J, CYS113I, CYS113J, CYS29I, CYS29J, GLN192I, GLN192J, GLN276I, GLN276J, GLN45I, GLN45J, GLU103I, GLU103J, GLU150I, GLU150J, GLU203I, GLU203J, GLU27I, GLU27J, GLU291I, GLY102I, GLY102J, GLY145I, GLY145J, GLY167I, GLY167J, GLY168I, GLY168J, GLY181I, GLY181J, GLY182I, GLY182J, GLY252I, GLY272I, GLY272J, GLY31I, GLY31J, GLY40I, GLY40J, GLY42I, GLY42J, HIS176I, HIS176J, HIS97I, HIS97J, ILE116I, ILE116J, ILE65I, ILE65J, LEU100I, LEU100J, LEU101I, LEU101J, LEU107I, LEU107J, LEU110I, LEU110J, LEU148I, LEU148J, LEU166I, LEU166J, LEU169I, LEU169J, LEU198I, LEU198J, LEU20I, LEU20J, LEU25I, LEU25J, LEU274I, LEU274J, LEU281I, LEU281J, LEU285I, LEU285J, LEU287I, LEU287J, LEU32I, LEU32J, LEU37I, LEU37J, LEU99I, LEU99J, LYS141I, LYS141J, LYS173I, LYS173J, LYS185I, LYS185J, LYS286I, LYS286J, LYS290I, LYS51I, LYS51J, MET171I, MET171J, MET273I, MET273J, PHE146I, PHE146J, PHE283I, PHE283J, PHE288I, PHE288J, PHE61I, PHE61J, PRO144I, PRO144J, PRO279I, PRO279J, PRO30I, PRO30J, SER205I, SER205J, SER23I, SER23J, SER284I, SER284J, SER39I, SER39J, SER44I, SER44J, THR109I, THR109J, THR139I, THR139J, THR142I, THR142J, THR143I, THR143J, THR275I, THR275J, TRP24I, TRP24J, TYR164I, TYR164J, TYR34I, TYR34J, VAL105I, VAL105J, VAL149I, VAL149J, VAL170I, VAL170J, VAL172I, VAL172J, VAL177I, VAL177J, VAL178I, VAL178J, VAL183I, VAL183J, VAL187I, VAL187J, VAL200I, VAL200J, VAL202I, VAL202J, VAL21I, VAL21J, VAL38I, VAL38J
• I-K: ALA18I, ALA18K, ALA19I, ALA19K, ALA35I, ALA36I, ALA41I, ALA64I, ALA96I, ALA9K, ARG147K, ARG163K, ARG26I, ASN33I, ASN70I, ASP165K, ASP22I, ASP4K, CYS29I, CYS98I, GLN68I, GLU150K, GLU6K, GLY145K, GLY153K, GLY167K, GLY168K, GLY31I, GLY40I, GLY42I, GLY7K, HIS162K, HIS97I, ILE65I, LEU101I, LEU10K, LEU11K, LEU12K, LEU148K, LEU154K, LEU155K, LEU17K, LEU20K, LEU25I, LEU32I, LEU37I, LEU69I, LEU8K, LYS151K, LYS290I, PHE61K, PRO13K, PRO14K, PRO30I, PRO95I, SER161K, SER23I, SER39I, THR16K, THR67I, TRP24I, TYR152K, TYR164K, TYR34I, VAL149K, VAL15K, VAL21I, VAL38I
• I-L: ARG26I, ARG26L, CYS29I, CYS29L, GLU27I, GLU27L, GLY31I, GLY31L, PRO30I, PRO30L, SER23I, SER23L
• J-K: ALA137J, ALA137K, ALA159J, ALA159K, ALA160J, ALA160K, ALA193J, ALA193K, ALA194J, ALA194K, ALA197J, ALA197K, ALA246J, ALA246K, ARG163J, ARG163K, ARG191J, ARG191K, ASP165J, ASP165K, ASP195J, ASP195K, ASP219J, ASP219K, ASP267J, ASP267K, ASP4J, ASP4K, GLN192J, GLN192K, GLU201J, GLU201K, GLU248J, GLU248K, GLY134J, GLY134K, GLY138K, GLY158K, GLY167J, GLY167K, GLY168J, GLY168K, HIS135J, HIS135K, HIS162J, HIS162K, ILE266J, ILE266K, ILE269J, ILE269K, LEU11J, LEU11K, LEU155J, LEU155K, LEU166J, LEU166K, LEU169J, LEU169K, LEU198J, LEU198K, LEU220J, LEU220K, LEU8J, LEU8K, LYS151K, LYS199J, LYS199K, LYS239J, LYS239K, PHE196J, PHE196K, PRO13J, PRO13K, PRO243J, SER161J, SER161K, SER244J, SER244K, THR133J, THR133K, TRP132J, TRP132K, TYR164J, TYR164K, VAL136J, VAL136K, VAL170J, VAL170K, VAL200J, VAL200K, VAL245J, VAL245K, VAL247J, VAL247K, VAL268J, VAL268K
• J-L: ALA160J, ALA18J, ALA18L, ALA19J, ALA19L, ALA35L, ALA36L, ALA41L, ALA5J, ALA64L, ALA96L, ALA9J, ARG147J, ARG163J, ARG26L, ASN33L, ASN70L, ASP165J, ASP22L, ASP28L, ASP4J, CYS29L, CYS98L, GLN68L, GLU150J, GLU6J, GLY145J, GLY153J, GLY167J, GLY168J, GLY31L, GLY40L, GLY42L, GLY7J, HIS162J, HIS97L, ILE65L, LEU101L, LEU10J, LEU11J, LEU12J, LEU148J, LEU154J, LEU155J, LEU17J, LEU20J, LEU25L, LEU32L, LEU37L, LEU69L, LEU8J, LYS151J, PHE61J, PRO13J, PRO14J, PRO30L, PRO95L, SER161J, SER23L, SER39L, THR16J, THR67L, TRP24L, TYR152J, TYR164J, TYR34L, VAL149J, VAL15J, VAL21L, VAL38L
• K-L: ALA106K, ALA106L, ALA111K, ALA111L, ALA179K, ALA179L, ALA180K, ALA180L, ALA186K, ALA186L, ALA189K, ALA189L, ALA190K, ALA190L, ALA193K, ALA193L, ALA194K, ALA194L, ALA197K, ALA197L, ALA277K, ALA277L, ALA278K, ALA278L, ALA280K, ALA280L, ALA35K, ALA35L, ALA36K, ALA36L, ALA41K, ALA41L, ALA46K, ALA46L, ALA47K, ALA47L, ALA96K, ALA96L, ARG104K, ARG104L, ARG112K, ARG112L, ARG140K, ARG140L, ARG147K, ARG147L, ARG163K, ARG163L, ARG188K, ARG188L, ARG191K, ARG191L, ARG26K, ARG26L, ASN108K, ASN108L, ASN175K, ASN175L, ASN225K, ASN225L, ASN33K, ASN33L, ASP165K, ASP165L, ASP174K, ASP174L, ASP195K, ASP195L, ASP224K, ASP282K, ASP282L, ASP28K, ASP28L, CYS113K, CYS113L, CYS29K, CYS29L, GLN192K, GLN192L, GLN276K, GLN276L, GLN45K, GLN45L, GLU103K, GLU103L, GLU150K, GLU150L, GLU184L, GLU203K, GLU203L, GLU27K, GLU27L, GLY102K, GLY102L, GLY115K, GLY115L, GLY145K, GLY145L, GLY167K, GLY167L, GLY168K, GLY168L, GLY181K, GLY181L, GLY182K, GLY182L, GLY252K, GLY252L, GLY272K, GLY272L, GLY31K, GLY31L, GLY40K, GLY40L, GLY42K, GLY42L, HIS176K, HIS176L, HIS97K, HIS97L, ILE116K, ILE116L, ILE65K, ILE65L, LEU100K, LEU100L, LEU101K, LEU101L, LEU107K, LEU107L, LEU110K, LEU110L, LEU148K, LEU148L, LEU166K, LEU166L, LEU169K, LEU169L, LEU198K, LEU198L, LEU20K, LEU20L, LEU25K, LEU25L, LEU274K, LEU274L, LEU281K, LEU281L, LEU285K, LEU285L, LEU287K, LEU287L, LEU32K, LEU32L, LEU37K, LEU37L, LEU99K, LEU99L, LYS141K, LYS141L, LYS173K, LYS173L, LYS185K, LYS185L, LYS286K, LYS286L, LYS51K, LYS51L, MET171K, MET171L, MET273K, MET273L, PHE146K, PHE146L, PHE283K, PHE283L, PHE288K, PHE288L, PHE61K, PHE61L, PRO144K, PRO144L, PRO279K, PRO279L, PRO30K, PRO30L, PRO95K, SER205K, SER23K, SER23L, SER284K, SER284L, SER39K, SER39L, SER44K, SER44L, THR109K, THR109L, THR139K, THR139L, THR142K, THR142L, THR143K, THR143L, THR275K, THR275L, TRP24K, TRP24L, TYR164K, TYR164L, TYR34K, TYR34L, VAL105K, VAL105L, VAL149K, VAL149L, VAL170K, VAL170L, VAL172K, VAL172L, VAL177K, VAL177L, VAL178K, VAL178L, VAL183K, VAL183L, VAL187K, VAL187L, VAL200K, VAL200L, VAL202K, VAL202L, VAL21K, VAL21L, VAL38K, VAL38L