2JA3

cytoplasmic domain of the human chloride transporter clc-5 in complex with adp

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 39
  • Norm. En. per Res.: -2.714
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-4.8212	71.2713	-159.168	-92.7178	88	13	4	8405	0	11	17
A-C	-7.7646	-13.0208	-69.8682	-90.6536	38	2	7	3691	2	14	6
A-D	0.0	0.0	-0.0434	-0.0434	2	0	0	19	0	0	2
A-E	-3.2487	-11.1502	-20.5844	-34.9832	23	0	3	1372	1	13	5
B-D	-11.5178	-17.5919	-76.7367	-105.8464	39	1	5	4034	2	11	5
B-E	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
B-F	0.0	0.0	-11.1267	-11.1267	20	0	0	895	0	7	5
C-D	-3.2324	70.2834	-178.127	-111.0759	89	9	4	8649	0	11	16
C-E	-13.6114	-18.1816	-24.7227	-56.5158	24	1	3	1518	2	14	4
C-F	0.0	1.8117	-1.7288	0.0828	8	0	0	304	0	5	6
D-F	-3.848	-13.3277	-30.2314	-47.4071	26	0	3	1894	1	13	4
E-F	-14.7185	46.355	-163.24	-131.6036	90	9	3	8277	0	11	18

Interface residues

• A-B: ALA582A, ALA582B, ARG630A, ARG630B, ARG680A, ARG680B, ARG704A, ARG704B, ARG718A, ARG718B, ASN716A, ASN716B, ASP684A, ASP684B, ASP692A, ASP692B, ASP701A, ASP701B, CYS711A, GLN600A, GLN600B, GLN629A, GLN629B, GLU664B, GLY633A, GLY633B, GLY707A, GLY707B, GLY717A, GLY717B, HIS715A, HIS715B, ILE698A, ILE698B, ILE702A, ILE702B, LEU581A, LEU581B, LEU631A, LEU631B, LEU683A, LEU683B, LEU685A, LEU685B, LEU693A, LEU693B, LEU706A, LEU706B, LEU708A, LEU708B, LEU719A, LEU719B, LYS705A, LYS705B, PHE688A, PHE688B, PHE703A, PHE703B, PRO687A, PRO687B, PRO695A, PRO695B, SER628A, SER628B, SER686A, SER686B, THR663A, THR663B, THR689A, THR689B, THR691A, THR691B, THR694A, THR694B, THR714A, THR714B, VAL622A, VAL622B, VAL623A, VAL623B, VAL624A, VAL624B, VAL632A, VAL632B, VAL690A, VAL690B, VAL699A, VAL699B
• A-C: ALA733A, ALA736A, ARG704A, ARG704C, ARG709A, ASN737A, ASN746C, ASP701A, GLN734A, GLN754C, GLU697C, GLU747C, GLU750C, GLY707A, HIS731A, ILE702A, ILE732A, LEU706A, LEU708A, LEU729A, LEU749A, LEU749C, LEU752C, LYS705A, LYS725A, LYS726A, LYS730A, MET735A, PHE703A, PHE745C, PHE748A, PHE748C, PHE753C, VAL699A, VAL700A, VAL728A, VAL751A, VAL751C
• A-D: LYS649A, LYS650D
• A-E: ALA733E, ALA736A, ALA736E, ARG704A, ARG704E, ASN746A, GLN734E, GLU747A, GLU750A, HIS731E, ILE732E, LEU729E, LEU749A, LYS725E, LYS726E, LYS730E, MET735E, PHE745A, PHE748A, PHE748E, VAL728E, VAL751A, VAL751E
• B-D: ALA733D, ALA736B, ALA736D, ARG704B, ARG704D, ASN737D, ASN746B, ASP701D, ASP727D, GLN734D, GLU747B, GLU750B, GLU750D, GLY707D, HIS731D, ILE702D, ILE732D, LEU706D, LEU708D, LEU729D, LEU749B, LEU752B, LEU752D, LYS705D, LYS725D, LYS726D, LYS730D, MET735D, PHE703D, PHE745B, PHE745D, PHE748B, PHE748D, PHE753B, VAL699D, VAL700D, VAL728D, VAL751B, VAL751D
• B-E: LYS649B, LYS649E
• B-F: ALA733B, ALA736B, ARG704B, ARG704F, ASN737B, ASN746F, GLU747F, ILE732B, ILE743F, LEU729B, LEU744F, LEU749F, LEU752B, LYS725B, LYS726B, LYS730B, PHE745F, PHE748B, PHE748F, VAL751B
• C-D: ARG630C, ARG630D, ARG680C, ARG680D, ARG704C, ARG704D, ARG718C, ARG718D, ASN716C, ASN716D, ASP684C, ASP684D, ASP692C, ASP692D, ASP701C, ASP701D, CYS711C, GLN600C, GLN600D, GLN629C, GLN629D, GLU664C, GLU664D, GLY633C, GLY633D, GLY707C, GLY707D, GLY717C, GLY717D, HIS715C, HIS715D, ILE698C, ILE698D, ILE702C, ILE702D, LEU581C, LEU581D, LEU631C, LEU631D, LEU683C, LEU683D, LEU685C, LEU685D, LEU693C, LEU693D, LEU706C, LEU706D, LEU708C, LEU708D, LEU719C, LEU719D, LYS579D, LYS705C, LYS705D, PHE688C, PHE688D, PHE703C, PHE703D, PRO687C, PRO687D, PRO695C, PRO695D, SER625C, SER628C, SER628D, SER686C, SER686D, THR663C, THR663D, THR689C, THR689D, THR691C, THR691D, THR694C, THR694D, THR714C, THR714D, VAL622C, VAL622D, VAL623C, VAL623D, VAL624C, VAL624D, VAL632C, VAL632D, VAL690C, VAL690D, VAL699C, VAL699D
• C-E: ALA733C, ALA736C, ARG704C, ARG704E, ASN746E, GLN734C, GLN754C, GLU697E, GLU747E, GLU750E, HIS731C, ILE732C, LEU729C, LEU749E, LEU752C, LYS725C, LYS726C, LYS730C, PHE745E, PHE748C, PHE748E, VAL728C, VAL751C, VAL751E
• C-F: ASN646C, ASN646F, GLU645C, ILE642C, ILE642F, LYS649C, LYS649F, LYS650C
• D-F: ALA733F, ARG704D, ARG704F, ASN746D, ASN746F, ASP727F, ASP739D, GLN734F, GLU697D, GLU747D, GLU750D, HIS731F, ILE732F, LEU729F, LEU749D, LEU749F, LEU752D, LYS725F, LYS726F, LYS730F, PHE745D, PHE745F, PHE748D, PHE748F, VAL728F, VAL751D
• E-F: ARG630E, ARG630F, ARG680E, ARG680F, ARG704E, ARG704F, ARG718E, ARG718F, ASN716E, ASN716F, ASP684E, ASP684F, ASP692E, ASP692F, ASP701E, ASP701F, CYS711F, GLN600E, GLN600F, GLN629E, GLN629F, GLU627E, GLU664E, GLU664F, GLY633E, GLY633F, GLY707E, GLY707F, GLY717E, GLY717F, HIS715E, HIS715F, ILE698E, ILE698F, ILE702E, ILE702F, LEU581E, LEU581F, LEU631E, LEU631F, LEU683E, LEU683F, LEU685E, LEU685F, LEU693E, LEU693F, LEU706E, LEU706F, LEU708E, LEU708F, LEU719E, LEU719F, LYS579F, LYS705E, LYS705F, PHE688E, PHE688F, PHE703E, PHE703F, PRO687E, PRO687F, PRO695E, PRO695F, SER625F, SER628E, SER628F, SER686E, SER686F, THR663E, THR663F, THR689E, THR689F, THR691E, THR691F, THR694E, THR694F, THR714E, THR714F, VAL622E, VAL622F, VAL623E, VAL623F, VAL624E, VAL624F, VAL632E, VAL632F, VAL690E, VAL690F, VAL699E, VAL699F