2J9F

human branched-chain alpha-ketoacid dehydrogenase- decarboxylase e1b

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-C
  • Int. Res.: 242
  • Norm. En. per Res.: -4.6661
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-68.105	33.0595	-577.648	-612.6935	175	18	10	20448	3	29	30
A-C	-195.6658	-31.657	-901.878	-1129.2008	242	31	23	33766	2	48	54
A-D	-75.0065	23.6405	-533.87	-585.236	178	10	12	19278	0	37	47
B-C	-66.7647	24.0484	-528.015	-570.7313	175	17	12	19475	0	37	50
B-D	-97.1204	-53.4917	-692.813	-843.4251	188	19	6	22786	10	36	32
C-D	-51.1411	17.2479	-570.676	-604.5692	174	18	11	20310	2	28	30

Interface residues

• A-B: ALA106B, ALA114B, ALA115B, ALA155B, ALA165A, ALA171A, ALA174A, ALA175A, ALA177A, ALA178A, ALA181A, ALA183A, ALA201A, ALA203A, ALA208A, ALA209A, ALA373A, ALA41B, ALA87B, ALA91B, ALA93B, ARG118B, ARG120B, ARG144A, ARG155A, ARG180A, ARG185A, ARG61B, ARG68B, ASN112B, ASN126B, ASN183B, ASN206A, ASN361A, ASN71B, ASP108B, ASP123B, ASP139A, ASP181B, ASP200A, ASP261B, ASP263B, ASP366A, ASP38B, ASP67B, CYS127B, CYS152A, CYS157B, CYS185B, CYS213A, CYS266B, CYS75B, GLN109B, GLN132A, GLN145A, GLN167A, GLN170A, GLN369A, GLN374A, GLN378A, GLN77B, GLU113B, GLU154A, GLU198A, GLU212A, GLU297B, GLU298B, GLU370A, GLU46B, GLU76B, GLY122B, GLY128B, GLY141A, GLY143A, GLY151A, GLY159B, GLY173A, GLY199A, GLY204A, GLY45B, GLY65B, GLY78B, GLY81B, GLY83B, GLY85B, GLY90B, HIS149A, HIS156A, HIS202A, ILE110B, ILE160A, ILE160B, ILE168A, ILE258B, ILE43B, ILE79B, ILE84B, ILE86B, LEU108A, LEU119A, LEU124B, LEU128A, LEU130B, LEU140A, LEU164A, LEU210B, LEU211A, LEU35B, LEU362A, LEU363A, LEU375A, LEU74B, LYS116B, LYS142A, LYS153A, LYS161B, LYS179A, LYS182B, LYS377A, LYS66B, MET146A, MET371A, PHE110A, PHE125B, PHE154B, PHE157A, PHE205A, PHE207A, PHE364A, PHE44B, PHE70B, PHE82B, PRO105B, PRO158B, PRO163A, PRO169A, PRO184B, PRO214A, PRO259B, PRO372A, PRO39B, PRO73B, SER121B, SER161A, SER162A, SER211B, SER365A, THR159A, THR166A, THR210A, THR294B, THR40B, THR72B, THR89B, THR92B, TRP260B, TYR117B, TYR119B, TYR124A, TYR150A, TYR176A, TYR368A, TYR64B, VAL109A, VAL111B, VAL158A, VAL162B, VAL172A, VAL187A, VAL262B, VAL367A, VAL42B, VAL69B, VAL80B, VAL88B
• A-C: ALA12A, ALA12C, ALA14A, ALA14C, ALA195A, ALA195C, ALA196A, ALA196C, ALA201A, ALA201C, ALA203A, ALA203C, ALA208A, ALA208C, ALA209A, ALA209C, ALA240A, ALA240C, ALA241A, ALA241C, ALA260A, ALA260C, ALA264A, ALA264C, ALA268A, ALA268C, ALA283A, ALA283C, ARG235A, ARG235C, ARG242A, ARG242C, ARG252A, ARG252C, ARG269A, ARG269C, ARG270A, ARG270C, ARG271A, ARG271C, ARG287A, ARG287C, ARG318A, ARG318C, ARG35A, ARG35C, ARG39A, ARG39C, ASN206A, ASN206C, ASN221A, ASN221C, ASN222A, ASN222C, ASN256A, ASN256C, ASN263A, ASN263C, ASN26A, ASN26C, ASN276A, ASN276C, ASN45A, ASN45C, ASP18A, ASP18C, ASP200A, ASP200C, ASP237A, ASP237C, ASP254A, ASP254C, ASP257A, ASP257C, ASP313A, ASP313C, ASP38A, ASP38C, CYS213A, CYS213C, GLN233A, GLN233C, GLN24A, GLN24C, GLN277A, GLN277C, GLN8A, GLN8C, GLU15A, GLU15C, GLU193A, GLU193C, GLU198A, GLU198C, GLU212A, GLU212C, GLU21A, GLU21C, GLU232A, GLU232C, GLU267A, GLU267C, GLU282A, GLU282C, GLU48A, GLU48C, GLY11A, GLY11C, GLY194A, GLY194C, GLY199A, GLY199C, GLY223A, GLY223C, GLY236A, GLY236C, GLY238A, GLY238C, GLY243A, GLY243C, GLY245A, GLY245C, GLY247A, GLY247C, GLY255A, GLY255C, GLY30A, GLY30C, GLY91A, GLY91C, HIS202A, HIS202C, ILE17A, ILE17C, ILE216A, ILE216C, ILE239A, ILE239C, ILE23A, ILE23C, ILE248A, ILE248C, ILE251A, ILE251C, ILE281A, ILE281C, ILE28A, ILE28C, ILE31A, ILE31C, ILE33A, ILE33C, ILE44A, ILE44C, LEU20A, LEU20C, LEU211A, LEU211C, LEU280A, LEU280C, LYS179A, LYS179C, LYS19A, LYS19C, LYS266A, LYS266C, LYS6A, LYS6C, MET249A, MET249C, MET284A, MET284C, MET37C, PHE16A, PHE16C, PHE205A, PHE205C, PHE207A, PHE207C, PHE22A, PHE22C, PHE259C, PHE279A, PHE279C, PHE9A, PHE9C, PRO10A, PRO10C, PRO229A, PRO229C, PRO244A, PRO244C, PRO25A, PRO25C, PRO278A, PRO278C, PRO315A, PRO315C, PRO32A, PRO32C, PRO46A, PRO46C, PRO7A, PRO7C, SER13A, SER13C, SER197A, SER197C, SER231A, SER231C, SER250A, SER250C, SER29A, SER29C, SER47A, SER47C, THR210A, THR210C, THR230A, THR230C, THR265A, THR265C, THR285A, THR285C, TYR224A, TYR224C, TYR234A, TYR234C, TYR246A, TYR246C, TYR262C, TYR286A, TYR286C, TYR34A, TYR34C, VAL253A, VAL253C, VAL261C, VAL27A, VAL27C, VAL36A, VAL36C
• A-D: ALA131A, ALA143D, ALA165A, ALA195A, ALA196A, ALA201A, ALA203A, ALA225A, ALA299A, ALA335D, ALA383A, ALA49D, ARG144A, ARG235A, ARG242A, ARG309D, ARG337D, ARG384A, ARG55D, ARG61D, ASN136A, ASN359A, ASN361A, ASN71D, ASP101D, ASP139A, ASP200A, ASP295A, ASP296A, ASP314D, ASP328D, ASP334D, ASP366A, ASP396A, ASP399A, ASP47D, CYS133A, CYS311D, CYS332D, CYS75D, GLN112A, GLN132A, GLN145A, GLN148D, GLN233A, GLN374A, GLN378A, GLN379A, GLN77D, GLN78A, GLN98D, GLU193A, GLU198A, GLU232A, GLU322D, GLU391A, GLU46D, GLU76D, GLY135A, GLY140D, GLY141A, GLY142D, GLY143A, GLY192A, GLY194A, GLY199A, GLY312D, GLY390A, GLY45D, GLY51D, GLY52D, GLY78D, HIS141D, HIS146D, HIS149A, HIS202A, HIS291A, HIS319D, HIS385A, HIS392A, HIS397A, ILE137A, ILE160A, ILE226A, ILE320D, ILE326D, ILE79D, ILE83A, LEU144D, LEU164A, LEU245D, LEU283D, LEU336D, LEU362A, LEU363A, LEU375A, LEU382A, LEU386A, LEU395A, LEU74D, LYS142A, LYS244D, LYS329D, LYS331D, LYS338D, LYS357A, LYS377A, LYS66D, MET146A, MET240D, MET371A, MET87A, PHE104D, PHE317D, PHE321D, PHE324D, PHE364A, PHE398A, PHE50D, PHE54D, PHE70D, PHE85A, PHE99D, PRO105D, PRO147A, PRO163A, PRO229A, PRO282D, PRO316D, PRO318D, PRO323D, PRO327D, PRO356A, PRO358A, PRO360A, PRO372A, PRO394A, PRO73D, SER147D, SER161A, SER162A, SER197A, SER227A, SER231A, SER294A, SER297A, SER298A, SER365A, SER381A, SER84A, THR159A, THR166A, THR228A, THR230A, THR284D, THR315D, THR388A, THR72D, TRP330D, TYR102D, TYR113A, TYR134A, TYR145D, TYR224A, TYR234A, TYR300A, TYR313D, TYR325D, TYR333D, TYR368A, TYR389A, TYR393A, VAL139D, VAL310D, VAL367A, VAL48D, VAL53D, VAL58D
• B-C: ALA131C, ALA143B, ALA165C, ALA195C, ALA196C, ALA201C, ALA203C, ALA225C, ALA299C, ALA335B, ALA383C, ALA49B, ARG144C, ARG235C, ARG242C, ARG309B, ARG337B, ARG384C, ARG55B, ARG61B, ARG82C, ASN136C, ASN359C, ASN361C, ASN71B, ASP101B, ASP139C, ASP200C, ASP295C, ASP296C, ASP314B, ASP328B, ASP334B, ASP366C, ASP396C, ASP399C, ASP47B, CYS133C, CYS311B, CYS332B, CYS75B, GLN112C, GLN132C, GLN145C, GLN148B, GLN233C, GLN374C, GLN378C, GLN379C, GLN77B, GLN78C, GLN98B, GLU193C, GLU198C, GLU232C, GLU322B, GLU380C, GLU391C, GLU46B, GLU76B, GLY135C, GLY140B, GLY141C, GLY142B, GLY143C, GLY192C, GLY194C, GLY199C, GLY312B, GLY390C, GLY45B, GLY51B, GLY52B, GLY78B, HIS141B, HIS146B, HIS149C, HIS202C, HIS291C, HIS319B, HIS385C, HIS392C, HIS397C, ILE137C, ILE160C, ILE226C, ILE320B, ILE326B, ILE79B, ILE83C, LEU144B, LEU164C, LEU283B, LEU362C, LEU363C, LEU375C, LEU382C, LEU386C, LEU395C, LEU74B, LYS142C, LYS244B, LYS329B, LYS331B, LYS338B, LYS357C, LYS377C, LYS66B, MET146C, MET240B, MET371C, MET87C, PHE104B, PHE317B, PHE321B, PHE324B, PHE364C, PHE398C, PHE50B, PHE54B, PHE70B, PHE85C, PHE99B, PRO105B, PRO147C, PRO163C, PRO229C, PRO282B, PRO316B, PRO318B, PRO323B, PRO327B, PRO356C, PRO358C, PRO360C, PRO372C, PRO394C, PRO73B, SER147B, SER161C, SER162C, SER197C, SER227C, SER294C, SER297C, SER298C, SER365C, SER381C, SER84C, THR159C, THR166C, THR228C, THR284B, THR315B, THR388C, THR72B, TRP330B, TYR102B, TYR113C, TYR134C, TYR145B, TYR224C, TYR234C, TYR300C, TYR313B, TYR325B, TYR333B, TYR368C, TYR389C, TYR393C, VAL139B, VAL367C, VAL48B, VAL53B, VAL58B
• B-D: ALA100B, ALA100D, ALA106B, ALA106D, ALA114B, ALA114D, ALA115B, ALA115D, ALA143B, ALA143D, ALA152B, ALA152D, ALA155B, ALA155D, ALA281B, ALA281D, ALA288B, ALA288D, ALA305B, ALA305D, ARG118B, ARG118D, ARG120B, ARG120D, ARG274B, ARG274D, ARG309B, ARG309D, ASN112B, ASN112D, ASN302B, ASN302D, ASP101B, ASP101D, ASP108B, ASP108D, ASP314B, ASP314D, CYS157B, CYS157D, CYS299B, CYS299D, CYS311B, CYS311D, CYS75B, CYS75D, GLN109B, GLN109D, GLN148B, GLN148D, GLN296B, GLN296D, GLN77B, GLN77D, GLU113B, GLU113D, GLU151B, GLU151D, GLU280B, GLU280D, GLU290B, GLU290D, GLU297B, GLU297D, GLU298B, GLU298D, GLU304B, GLU304D, GLU76B, GLU76D, GLY159B, GLY159D, GLY273B, GLY273D, GLY285B, GLY285D, GLY286B, GLY286D, GLY312B, GLY312D, HIS156B, HIS156D, HIS279B, HIS279D, HIS319B, HIS319D, ILE103B, ILE103D, ILE110B, ILE110D, ILE160B, ILE160D, ILE257B, ILE257D, ILE258B, ILE258D, ILE277B, ILE277D, ILE291B, ILE291D, ILE307B, ILE307D, LEU144B, LEU144D, LEU275B, LEU275D, LEU283B, LEU283D, LEU301B, LEU301D, LEU303B, LEU303D, LYS116B, LYS116D, PHE104B, PHE104D, PHE107B, PHE107D, PHE153B, PHE153D, PHE154B, PHE154D, PHE287B, PHE287D, PHE300B, PHE300D, PHE317B, PHE317D, PHE321B, PHE321D, PRO105B, PRO105D, PRO150B, PRO150D, PRO158B, PRO158D, PRO259B, PRO259D, PRO282B, PRO282D, PRO306B, PRO306D, PRO316B, PRO316D, PRO318B, PRO318D, SER121B, SER121D, SER149B, SER149D, SER289B, SER289D, SER292B, SER292D, SER293B, SER293D, SER308B, SER308D, THR284B, THR284D, THR294B, THR294D, THR315B, THR315D, TRP260B, TRP260D, TYR102B, TYR102D, TYR117B, TYR117D, TYR119B, TYR119D, TYR145B, TYR145D, TYR313B, TYR313D, TYR325B, TYR325D, TYR342B, TYR342D, VAL111B, VAL111D, VAL262B, VAL262D, VAL295B, VAL295D, VAL310B, VAL310D
• C-D: ALA106D, ALA114D, ALA115D, ALA155D, ALA165C, ALA171C, ALA174C, ALA175C, ALA177C, ALA178C, ALA181C, ALA201C, ALA203C, ALA208C, ALA209C, ALA373C, ALA41D, ALA87D, ALA91D, ALA93D, ARG118D, ARG120D, ARG144C, ARG155C, ARG180C, ARG185C, ARG61D, ARG68D, ASN112D, ASN126D, ASN183D, ASN206C, ASN361C, ASN71D, ASP108D, ASP123D, ASP139C, ASP181D, ASP200C, ASP261D, ASP263D, ASP366C, ASP38D, ASP67D, CYS127D, CYS152C, CYS157D, CYS185D, CYS213C, CYS266D, CYS75D, GLN109D, GLN132C, GLN145C, GLN167C, GLN170C, GLN369C, GLN374C, GLN378C, GLN77D, GLU113D, GLU154C, GLU198C, GLU297D, GLU298D, GLU370C, GLU46D, GLU76D, GLY122D, GLY128D, GLY141C, GLY143C, GLY151C, GLY159D, GLY173C, GLY199C, GLY204C, GLY45D, GLY65D, GLY78D, GLY81D, GLY83D, GLY85D, GLY90D, HIS149C, HIS156C, HIS202C, ILE110D, ILE160C, ILE160D, ILE168C, ILE258D, ILE43D, ILE79D, ILE84D, ILE86D, LEU108C, LEU119C, LEU124D, LEU128C, LEU130D, LEU140C, LEU164C, LEU210D, LEU211C, LEU35D, LEU362C, LEU363C, LEU375C, LEU74D, LYS116D, LYS142C, LYS153C, LYS161D, LYS179C, LYS182D, LYS377C, LYS66D, MET146C, MET371C, PHE110C, PHE125D, PHE154D, PHE157C, PHE205C, PHE207C, PHE364C, PHE44D, PHE70D, PHE82D, PRO105D, PRO158D, PRO163C, PRO169C, PRO184D, PRO259D, PRO360C, PRO372C, PRO39D, PRO73D, SER121D, SER161C, SER162C, SER211D, SER365C, THR159C, THR166C, THR210C, THR294D, THR40D, THR72D, THR89D, THR92D, TRP260D, TYR117D, TYR119D, TYR124C, TYR150C, TYR176C, TYR246C, TYR368C, TYR64D, VAL109C, VAL111D, VAL158C, VAL162D, VAL172C, VAL187C, VAL262D, VAL367C, VAL42D, VAL69D, VAL80D, VAL88D