2J7A

crystal structure of cytochrome c nitrite reductase nrfha complex from desulfovibrio vulgaris

• Total interactions analyzed: 153
• Total true interactions: 44
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 118
  • Norm. En. per Res.: -5.0329
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-17.7705	-24.8847	-287.092	-329.7472	151	19	13	11935	4	37	41
A-C	-47.3817	-30.3975	-264.554	-342.3332	92	10	4	10745	5	37	39
A-D	-65.4368	-35.4103	-173.686	-274.5331	106	18	0	7937	11	78	71
A-E	0.0	8.961	-1.6871	7.2739	8	0	0	77	0	1	4
A-F	-20.8169	-35.6095	-92.1406	-148.567	45	4	0	3453	3	19	16
B-C	-87.2199	-101.0159	-405.648	-593.8838	118	17	5	16203	8	51	45
B-D	0.0	0.0	26.4183	26.4183	14	4	0	216	3	1	4
B-H	-12.6554	-0.4027	-36.3387	-49.3968	31	1	0	1448	0	13	15
C-D	-23.4116	-11.7559	-84.2175	-119.385	44	3	0	3304	3	19	16
C-E	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
C-F	0.0	0.0	-125.31	-125.31	78	4	10	5632	0	4	7
D-E	-6.6278	-20.5149	-153.064	-180.2067	153	20	13	11581	8	36	41
D-F	-47.299	-29.505	-264.552	-341.3561	95	5	4	10836	1	37	40
D-M	0.0	0.0	-9.7085	-9.7085	22	0	1	643	0	5	2
D-N	-7.6478	0.7586	-46.7222	-53.6114	29	1	2	2109	0	4	1
E-F	-74.8958	-87.8312	-361.432	-524.159	121	20	5	15856	6	48	46
E-M	0.0	0.0	-4.4516	-4.4516	7	0	0	95	0	0	0
E-N	-3.9603	-10.218	-47.6233	-61.8017	34	2	0	1874	1	11	7
G-H	0.0	-27.1459	-291.206	-318.3519	142	11	13	11904	4	38	42
G-I	-62.8147	-28.7269	-264.485	-356.0266	96	10	4	10781	5	37	40
G-J	-75.0715	-40.6902	-168.708	-284.4696	106	12	0	7921	14	79	72
G-K	0.0	0.0	-1.9244	-1.9244	8	0	0	74	0	1	4
G-L	-23.8332	-15.8687	-86.0143	-125.7162	43	4	0	3368	4	19	15
H-I	-69.4818	-79.0837	-400.497	-549.0625	120	15	4	15857	7	48	46
H-J	0.0	0.0	-1.3108	-1.3108	4	0	0	53	0	1	4
H-L	0.0	0.0	-0.0006	-0.0006	2	0	0	2	0	0	0
I-J	-25.3011	-13.6092	-85.0133	-123.9236	44	4	0	3349	3	19	16
I-K	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	0	0
I-L	0.0	0.0	-132.536	-132.536	76	3	12	5851	0	4	7
J-K	-5.8844	-26.0853	-266.414	-298.3837	142	11	13	11430	4	38	43
J-L	-54.9471	-21.7887	-263.143	-339.8788	92	9	4	10710	5	37	39
K-L	-46.6516	-97.3225	-367.949	-511.9231	124	26	6	16008	8	50	46
M-N	-21.5585	-24.6343	-285.495	-331.6878	149	13	14	11920	4	38	44
M-O	-47.2884	-25.2093	-262.221	-334.7187	93	9	4	10756	5	37	40
M-P	-58.8839	-39.5921	-181.944	-280.4199	106	12	0	7899	16	79	74
M-Q	0.0	0.0	-1.3358	-1.3358	8	0	0	67	0	0	2
M-R	-10.5908	-22.7644			9
N-O	-73.3256	-81.5344	-412.653	-567.513	122	19	5	16504	7	50	47
N-P	0.0	0.0	-9.5403	-9.5403	24	8	0	439	0	1	4
O-P	-35.537	-17.3145	-84.5687	-137.4202	44	5	0	3489	3	19	16
O-Q	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
P-Q	-9.3143	-19.8695	0.0	-29.1838	16	0	0	0	0	0	0
P-R	-53.5819	-24.838			23
Q-R	-70.9785	-84.0569			31

Interface residues

• A-B: ALA311A, ALA311B, ALA312A, ALA312B, ALA378A, ALA378B, ALA379A, ALA379B, ALA401A, ALA401B, ALA437A, ALA437B, ALA439A, ALA439B, ALA444A, ALA444B, ALA460A, ALA460B, ARG364A, ARG364B, ARG371A, ARG371B, ASN306A, ASN306B, ASN435A, ASN435B, ASP258A, ASP258B, ASP261B, ASP355A, ASP355B, ASP359A, ASP374A, ASP374B, ASP441A, ASP441B, ASP455A, ASP455B, ASP468A, ASP468B, ASP472A, ASP472B, GLN369A, GLN369B, GLN380A, GLN380B, GLN445A, GLN445B, GLN447A, GLN447B, GLN448A, GLN448B, GLN451A, GLN451B, GLN462A, GLN462B, GLU302B, GLU381A, GLU381B, GLU459A, GLU459B, GLY307A, GLY307B, GLY310A, GLY310B, GLY313A, GLY313B, GLY432B, GLY464A, GLY464B, GLY466A, GLY466B, GLY471A, GLY471B, HIS1B, HIS309A, HIS309B, HIS353A, HIS353B, HIS434A, HIS434B, ILE305A, ILE305B, ILE454A, ILE454B, ILE465A, ILE465B, ILE476B, LEU375A, LEU375B, LEU376A, LEU376B, LEU377A, LEU377B, LEU407A, LEU407B, LEU440A, LEU440B, LEU443A, LEU443B, LEU456A, LEU456B, LEU469A, LEU469B, LYS356A, LYS356B, LYS370A, LYS370B, LYS385A, LYS385B, LYS438A, LYS438B, LYS452A, LYS452B, LYS467A, LYS467B, MET458A, MET458B, PHE367A, PHE367B, PHE449A, PHE449B, PRO259A, PRO259B, PRO436A, PRO436B, SER363A, SER363B, SER446B, SER470A, SER470B, THR303A, THR303B, THR308A, THR308B, THR368A, THR368B, THR372A, THR372B, THR442A, THR442B, TRP304A, TRP304B, TYR360A, TYR360B, TYR463A, TYR463B, VAL314A, VAL314B, VAL382A, VAL382B
• A-C: ALA114C, ALA118C, ALA128C, ALA132C, ALA312A, ALA317A, ALA348A, ARG141C, ARG147C, ARG221A, ARG225A, ARG325A, ARG350A, ASN113C, ASN115C, ASN124C, ASN142C, ASN222A, ASN74C, ASP138C, ASP318A, ASP327A, ASP355A, CYS116C, CYS119C, CYS136C, CYS139C, CYS27A, CYS319A, CYS349A, CYS352A, GLN351A, GLN60A, GLU126C, GLU131C, GLU223A, GLU33A, GLY26A, GLY313A, HIS120C, HIS140C, HIS309A, HIS335A, HIS353A, HIS73C, ILE332A, LEU198A, LEU34A, LEU361A, LEU75C, LYS117C, LYS133C, LYS134C, LYS149C, LYS329A, LYS330A, LYS331A, LYS356A, LYS35A, LYS59A, MET122C, MET130C, MET146C, MET148C, MET224A, PRO150C, PRO220A, PRO37A, SER129C, SER28A, SER31A, SER322A, SER333A, SER334A, SER354A, THR121C, THR123C, THR137C, THR153C, THR315A, THR324A, THR32A, THR36A, TRP304A, TYR323A, TYR39A, VAL125C, VAL127C, VAL143C, VAL30A, VAL314A, VAL38A
• A-D: ALA348D, ALA62A, ALA62D, ARG325A, ARG325D, ARG347A, ARG347D, ARG350A, ARG350D, ARG66A, ARG66D, ARG96A, ARG96D, ASN89A, ASN89D, ASP327A, ASP327D, ASP328A, ASP328D, ASP343A, ASP343D, ASP355A, ASP355D, ASP359A, ASP359D, CYS349D, CYS352A, CYS352D, GLN351A, GLN351D, GLU345A, GLU345D, GLU65A, GLU65D, GLU69A, GLU69D, GLU75A, GLU75D, GLU93A, HIS353A, HIS353D, ILE332A, ILE332D, LEU91A, LEU91D, LYS329A, LYS329D, LYS330A, LYS330D, LYS342A, LYS342D, LYS356A, LYS356D, LYS362A, LYS362D, LYS59A, LYS59D, MET341A, MET341D, MET346A, MET346D, MET73A, MET73D, PRO340A, PRO340D, PRO344A, PRO344D, PRO358A, PRO358D, PRO58A, PRO58D, PRO90A, PRO90D, PRO92A, PRO92D, SER322D, SER326A, SER326D, SER334A, SER334D, SER339A, SER339D, SER354A, SER354D, SER63A, SER63D, THR324A, THR324D, THR338A, THR338D, THR357A, THR357D, THR71A, THR71D, THR74A, THR74D, TRP336A, TRP336D, TYR323A, TYR323D, TYR360A, TYR360D, TYR95A, TYR95D, VAL72A, VAL72D
• A-E: ASP29A, ASP29E, LYS218E, LYS42A, SER31A, THR32A, THR32E, VAL30E
• A-F: ALA28F, ALA31F, ALA62F, ARG325A, ARG40F, ASN142F, ASN63F, ASN67F, ASP29A, ASP327A, ASP328A, ASP38F, ASP68F, CYS27A, CYS66F, GLN39F, GLU33A, GLY26A, GLY33F, GLY60F, HIS140F, HIS56F, HIS61F, ILE64F, LEU34A, LEU58F, LYS149F, LYS329A, LYS330A, LYS35F, LYS57F, MET146F, MET34F, PHE32F, PHE42F, PRO41F, SER28A, SER31A, SER59F, SER65F, THR32A, THR37F, TYR36F, VAL143F, VAL30A
• B-C: ALA104C, ALA157C, ALA25B, ALA311B, ALA312B, ALA317B, ALA348B, ARG141C, ARG147C, ARG154C, ARG221B, ARG225B, ARG325B, ARG347B, ARG350B, ARG40C, ASN222B, ASN50C, ASN93C, ASP100C, ASP138C, ASP158C, ASP29B, ASP318B, ASP328B, ASP343B, ASP355B, ASP89C, CYS27B, CYS319B, CYS349B, CYS352B, CYS43C, CYS46C, GLN144C, GLN351B, GLN39C, GLN60B, GLU155C, GLU223B, GLU33B, GLU345B, GLY26B, GLY310B, GLY313B, GLY33C, GLY53C, GLY96C, GLY99C, HIS309B, HIS335B, HIS353B, HIS47C, HIS56C, HIS97C, ILE102C, ILE151C, ILE332B, ILE48C, LEU101C, LEU103C, LEU34B, LEU361B, LEU58C, LEU95C, LYS109C, LYS149C, LYS329B, LYS330B, LYS331B, LYS356B, LYS35B, LYS57C, MET146C, MET148C, MET321B, MET346B, MET49C, MET92C, PHE42C, PRO150C, PRO358B, PRO37B, PRO41C, PRO51C, PRO98C, SER152C, SER28B, SER31B, SER322B, SER326B, SER333B, SER334B, SER354B, SER45C, SER59C, THR137C, THR153C, THR315B, THR324B, THR32B, THR36B, THR37C, THR44C, THR55C, THR94C, TRP304B, TYR135C, TYR323B, TYR36C, TYR39B, TYR91C, VAL156C, VAL30B, VAL314B, VAL52C, VAL54C, VAL90C
• B-D: ALA62D, ARG66D, ASP29B, ASP68D, GLU65D, HIS1B, LYS181D, LYS218B, LYS42D, LYS54D, SER31D, THR32B, THR32D, TYR61D
• B-H: ALA522H, ARG347B, ARG49H, ARG518H, ARG66B, ARG96B, ASN89B, ASP176H, ASP179H, ASP343B, ASP359B, ASP514H, GLU345B, HIS183H, LEU366B, LEU519H, LYS177H, LYS342B, LYS362B, LYS517H, MET346B, PRO344B, PRO358B, PRO90B, SER521H, THR71B, TRP336B, VAL512H, VAL520H, VAL72B, VAL88B
• C-D: ALA28C, ALA31C, ALA62C, ARG325D, ARG40C, ASN142C, ASN63C, ASN67C, ASP29D, ASP327D, ASP328D, ASP38C, ASP68C, CYS139C, CYS27D, CYS66C, GLN39C, GLU33D, GLY26D, GLY33C, GLY60C, HIS140C, HIS56C, HIS61C, ILE64C, LEU34D, LEU58C, LYS149C, LYS329D, LYS330D, LYS35C, LYS57C, MET146C, MET34C, PHE32C, PRO41C, SER28D, SER31D, SER59C, SER65C, THR32D, TYR36C, VAL143C, VAL30D
• C-E: MET122C, THR32E
• C-F: ALA118C, ALA118F, ALA20C, ALA20F, ALA26C, ALA26F, ALA28C, ALA28F, ALA31C, ALA31F, ALA62C, ALA62F, ARG40C, ARG40F, ASN124C, ASN124F, ASN63C, ASN63F, CYS119C, CYS119F, GLY18C, GLY18F, GLY19C, GLY19F, GLY23C, GLY23F, GLY60C, GLY60F, HIS120C, HIS120F, HIS56C, HIS56F, HIS61C, HIS61F, ILE64C, ILE64F, LEU15C, LEU15F, LEU17C, LEU17F, LEU22C, LEU22F, LEU27C, LEU27F, LEU58C, LEU58F, LEU75C, LYS117C, LYS117F, LYS14C, LYS35F, LYS57C, LYS57F, MET122C, MET122F, MET146C, MET146F, SER59C, SER59F, THR121C, THR121F, THR123C, THR123F, THR21C, THR21F, THR29C, THR29F, THR55F, VAL125C, VAL125F, VAL16C, VAL16F, VAL24C, VAL24F, VAL25C, VAL25F, VAL30C, VAL30F
• D-E: ALA260D, ALA311D, ALA311E, ALA312D, ALA312E, ALA378D, ALA378E, ALA379D, ALA379E, ALA401E, ALA402D, ALA437D, ALA437E, ALA439D, ALA439E, ALA444D, ALA444E, ALA460E, ARG364D, ARG364E, ARG371D, ARG371E, ASN306D, ASN306E, ASN435D, ASN435E, ASP258D, ASP258E, ASP261E, ASP355D, ASP355E, ASP374D, ASP374E, ASP405D, ASP406D, ASP441D, ASP441E, ASP455D, ASP455E, ASP468D, ASP468E, ASP472D, ASP472E, GLN369D, GLN369E, GLN380D, GLN445D, GLN445E, GLN447D, GLN447E, GLN448D, GLN448E, GLN451D, GLN451E, GLN462D, GLN462E, GLU381D, GLU381E, GLU459D, GLU459E, GLY307D, GLY307E, GLY310D, GLY310E, GLY313D, GLY313E, GLY403D, GLY464D, GLY464E, GLY466D, GLY466E, GLY471D, GLY471E, HIS1E, HIS309D, HIS309E, HIS353D, HIS353E, HIS434D, HIS434E, ILE305D, ILE305E, ILE409D, ILE454D, ILE454E, ILE465D, ILE465E, LEU375D, LEU375E, LEU376D, LEU376E, LEU377D, LEU377E, LEU407D, LEU407E, LEU440D, LEU440E, LEU443D, LEU443E, LEU456D, LEU456E, LEU469D, LEU469E, LYS275D, LYS356D, LYS356E, LYS370D, LYS370E, LYS385D, LYS385E, LYS400D, LYS438D, LYS438E, LYS452D, LYS452E, LYS467D, LYS467E, MET408D, MET458D, MET458E, PHE367D, PHE367E, PHE421D, PHE449D, PRO259D, PRO259E, PRO436D, PRO436E, SER363D, SER363E, SER470D, SER470E, THR303D, THR303E, THR308D, THR308E, THR368D, THR368E, THR372D, THR372E, THR442D, THR442E, TRP304D, TRP304E, TYR360D, TYR360E, TYR404D, TYR463D, TYR463E, VAL314D, VAL314E, VAL382D, VAL382E
• D-F: ALA114F, ALA118F, ALA128F, ALA132F, ALA312D, ALA317D, ALA348D, ARG141F, ARG147F, ARG221D, ARG225D, ARG325D, ARG350D, ASN113F, ASN115F, ASN124F, ASN142F, ASN222D, ASN74F, ASP138F, ASP318D, ASP327D, ASP328D, ASP355D, CYS116F, CYS119F, CYS136F, CYS139F, CYS319D, CYS349D, CYS352D, GLN144F, GLN351D, GLN60D, GLU126F, GLU131F, GLU197D, GLU223D, GLU33D, GLY26D, GLY313D, HIS120F, HIS140F, HIS309D, HIS335D, HIS353D, HIS73F, ILE332D, LEU198D, LEU34D, LEU361D, LEU75F, LYS117F, LYS133F, LYS134F, LYS149F, LYS329D, LYS330D, LYS331D, LYS356D, LYS35D, LYS59D, MET122F, MET130F, MET146F, MET148F, MET224D, MET321D, PHE57D, PRO150F, PRO220D, PRO37D, SER129F, SER28D, SER31D, SER322D, SER333D, SER334D, SER354D, THR121F, THR123F, THR137F, THR315D, THR324D, THR32D, THR36D, TRP304D, TYR323D, TYR39D, VAL125F, VAL127F, VAL143F, VAL30D, VAL314D, VAL38D
• D-M: ALA399M, ALA401D, ALA402D, ASP405D, ASP406D, GLN397M, GLN462M, GLY398M, GLY403D, GLY464M, GLY466M, ILE409D, ILE465M, LYS275D, LYS400D, LYS400M, LYS467M, MET458M, THR461M, TYR396M, TYR404D, TYR463M
• D-N: ALA399D, ALA399N, ALA401D, ALA402D, ALA460D, ASP468N, GLN397N, GLN462D, GLN462N, GLU459D, GLY398D, GLY398N, GLY403D, GLY464D, GLY464N, GLY466N, ILE465N, LEU407D, LYS400D, LYS400N, LYS467N, MET458D, MET458N, THR461D, THR461N, TYR396N, TYR404D, TYR463D, TYR463N
• E-F: ALA104F, ALA157F, ALA311E, ALA312E, ALA317E, ALA348E, ARG141F, ARG147F, ARG154F, ARG221E, ARG225E, ARG325E, ARG347E, ARG350E, ARG40F, ASN222E, ASN50F, ASN93F, ASP100F, ASP138F, ASP158F, ASP29E, ASP318E, ASP327E, ASP328E, ASP343E, ASP355E, CYS27E, CYS319E, CYS349E, CYS352E, CYS43F, CYS46F, GLN144F, GLN351E, GLN39F, GLN60E, GLU155F, GLU223E, GLU33E, GLU345E, GLY26E, GLY310E, GLY313E, GLY53F, GLY96F, GLY99F, HIS309E, HIS335E, HIS353E, HIS47F, HIS56F, HIS97F, ILE102F, ILE151F, ILE332E, ILE48F, LEU101F, LEU103F, LEU34E, LEU361E, LEU58F, LEU95F, LYS109F, LYS149F, LYS329E, LYS330E, LYS331E, LYS356E, LYS35E, LYS57F, LYS59E, MET146F, MET148F, MET224E, MET321E, MET346E, MET49F, MET92F, PHE32F, PHE42F, PRO150F, PRO220E, PRO358E, PRO37E, PRO41F, PRO51F, PRO98F, SER152F, SER28E, SER31E, SER322E, SER326E, SER333E, SER334E, SER354E, SER45F, SER59F, THR137F, THR153F, THR315E, THR324E, THR32E, THR36E, THR37F, THR44F, THR55F, THR94F, TRP304E, TYR135F, TYR323E, TYR36F, TYR39E, TYR91F, VAL156F, VAL30E, VAL314E, VAL38E, VAL52F, VAL54F, VAL90F
• E-M: ALA399M, GLN397M, GLN462M, GLY398M, GLY464M, HIS1E, TYR396M
• E-N: ALA393N, ALA399N, ALA401N, ALA402N, ASN394N, ASP405N, ASP468E, ASP472E, GLN397N, GLN462E, GLN462N, GLU395N, GLY398E, GLY398N, GLY403N, GLY464E, GLY466E, GLY471E, ILE465E, ILE476E, LEU392E, LEU469E, LYS275N, LYS400N, LYS467E, LYS495E, LYS498E, SER470E, THR461N, THR475E, TYR396E, TYR396N, TYR404N, TYR463E
• G-H: ALA260H, ALA311G, ALA311H, ALA312G, ALA312H, ALA378G, ALA378H, ALA379G, ALA379H, ALA437G, ALA437H, ALA439G, ALA439H, ALA444G, ALA444H, ALA460G, ARG364G, ARG364H, ARG371G, ARG371H, ASN306G, ASN306H, ASN435G, ASN435H, ASP258G, ASP258H, ASP355G, ASP355H, ASP374G, ASP374H, ASP441G, ASP441H, ASP455G, ASP455H, ASP468G, ASP468H, ASP472G, ASP472H, GLN369G, GLN369H, GLN380H, GLN445G, GLN445H, GLN447G, GLN447H, GLN448G, GLN448H, GLN451G, GLN451H, GLN462G, GLN462H, GLU381H, GLU459G, GLU459H, GLY307G, GLY307H, GLY310G, GLY310H, GLY313G, GLY313H, GLY432H, GLY464G, GLY464H, GLY466G, GLY466H, GLY471G, GLY471H, HIS309G, HIS309H, HIS353G, HIS353H, HIS434G, HIS434H, ILE305G, ILE305H, ILE454G, ILE454H, ILE465G, ILE465H, ILE476H, LEU375G, LEU375H, LEU376G, LEU376H, LEU377G, LEU377H, LEU407G, LEU407H, LEU440G, LEU440H, LEU443G, LEU443H, LEU456G, LEU456H, LEU469G, LEU469H, LYS356G, LYS356H, LYS370G, LYS370H, LYS385G, LYS385H, LYS438G, LYS438H, LYS452G, LYS452H, LYS467G, LYS467H, MET458G, MET458H, PHE367G, PHE367H, PHE449H, PRO259G, PRO259H, PRO436G, PRO436H, SER363G, SER363H, SER446H, SER470G, SER470H, THR303G, THR303H, THR308G, THR308H, THR368G, THR368H, THR372G, THR372H, THR442G, THR442H, TRP304G, TRP304H, TYR360G, TYR360H, TYR463G, TYR463H, VAL314G, VAL314H, VAL382G, VAL382H
• G-I: ALA114I, ALA118I, ALA128I, ALA132I, ALA312G, ALA317G, ALA348G, ARG141I, ARG147I, ARG221G, ARG225G, ARG325G, ARG350G, ASN113I, ASN115I, ASN124I, ASN142I, ASN222G, ASN74I, ASP138I, ASP318G, ASP327G, ASP328G, ASP355G, CYS116I, CYS119I, CYS136I, CYS139I, CYS27G, CYS319G, CYS349G, CYS352G, GLN144I, GLN351G, GLN60G, GLU126I, GLU131I, GLU223G, GLU33G, GLY26G, GLY313G, HIS120I, HIS140I, HIS309G, HIS335G, HIS353G, HIS73I, ILE332G, LEU198G, LEU34G, LEU361G, LEU75I, LYS117I, LYS133I, LYS134I, LYS149I, LYS329G, LYS330G, LYS331G, LYS356G, LYS35G, LYS59G, MET122I, MET130I, MET146I, MET148I, MET224G, MET321G, PRO150I, PRO220G, PRO37G, SER129I, SER28G, SER31G, SER322G, SER333G, SER334G, SER354G, THR121I, THR123I, THR137I, THR153I, THR308G, THR315G, THR324G, THR32G, THR36G, TRP304G, TYR323G, TYR39G, VAL125I, VAL127I, VAL143I, VAL30G, VAL314G, VAL38G
• G-J: ALA348J, ALA62G, ALA62J, ARG325G, ARG325J, ARG347G, ARG347J, ARG350G, ARG350J, ARG66G, ARG66J, ARG96G, ARG96J, ASN89G, ASN89J, ASP327G, ASP327J, ASP328G, ASP328J, ASP343G, ASP343J, ASP355G, ASP355J, ASP359G, ASP359J, CYS349J, CYS352G, CYS352J, GLN351G, GLN351J, GLU345G, GLU345J, GLU65G, GLU65J, GLU69G, GLU69J, GLU75G, GLU75J, GLU93G, GLU93J, HIS353G, HIS353J, ILE332G, LEU91G, LEU91J, LYS329G, LYS329J, LYS330G, LYS330J, LYS342G, LYS342J, LYS356G, LYS356J, LYS362G, LYS362J, LYS59G, LYS59J, MET341G, MET341J, MET346G, MET346J, MET73G, MET73J, PRO340G, PRO340J, PRO344G, PRO344J, PRO358G, PRO358J, PRO58G, PRO58J, PRO90G, PRO90J, PRO92G, PRO92J, SER326G, SER326J, SER334G, SER334J, SER339G, SER339J, SER354G, SER354J, SER63G, SER63J, THR324G, THR324J, THR338G, THR338J, THR357G, THR357J, THR70G, THR71G, THR71J, THR74G, THR74J, TRP336G, TRP336J, TYR323G, TYR323J, TYR360G, TYR360J, TYR95G, TYR95J, VAL72G, VAL72J
• G-K: ASP29G, ASP29K, LYS218K, LYS42G, SER31G, THR32G, THR32K, VAL30K
• G-L: ALA28L, ALA31L, ALA62L, ARG325G, ARG40L, ASN142L, ASN63L, ASN67L, ASP29G, ASP327G, ASP328G, ASP38L, ASP68L, CYS27G, CYS66L, GLN39L, GLU33G, GLY26G, GLY33L, GLY60L, HIS140L, HIS56L, HIS61L, ILE64L, LEU34G, LEU58L, LYS149L, LYS329G, LYS330G, LYS35L, LYS57L, MET146L, MET34L, PHE32L, PRO41L, SER28G, SER31G, SER59L, SER65L, THR32G, TYR36L, VAL143L, VAL30G
• H-I: ALA104I, ALA157I, ALA312H, ALA317H, ALA348H, ALA62I, ARG141I, ARG147I, ARG154I, ARG221H, ARG225H, ARG325H, ARG347H, ARG350H, ARG40I, ASN222H, ASN50I, ASN93I, ASP100I, ASP138I, ASP158I, ASP29H, ASP318H, ASP328H, ASP343H, ASP355H, ASP89I, CYS27H, CYS319H, CYS349H, CYS352H, CYS43I, CYS46I, GLN144I, GLN351H, GLN39I, GLN60H, GLU155I, GLU223H, GLU33H, GLU345H, GLY26H, GLY310H, GLY313H, GLY53I, GLY96I, GLY99I, HIS145I, HIS309H, HIS335H, HIS353H, HIS47I, HIS56I, HIS97I, ILE102I, ILE151I, ILE332H, ILE48I, LEU101I, LEU103I, LEU34H, LEU361H, LEU58I, LEU95I, LYS109I, LYS149I, LYS329H, LYS330H, LYS331H, LYS356H, LYS35H, LYS57I, LYS59H, MET146I, MET148I, MET224H, MET321H, MET346H, MET49I, MET92I, PHE42I, PRO150I, PRO220H, PRO358H, PRO37H, PRO41I, PRO51I, PRO98I, SER152I, SER28H, SER31H, SER322H, SER326H, SER333H, SER334H, SER354H, SER45I, SER59I, THR137I, THR153I, THR315H, THR324H, THR32H, THR36H, THR37I, THR44I, THR55I, THR94I, TRP304H, TYR135I, TYR323H, TYR36I, TYR39H, TYR91I, VAL156I, VAL30H, VAL314H, VAL52I, VAL54I, VAL90I
• H-J: ASP29H, SER31J, THR32H, THR32J
• H-L: MET122L, THR32H
• I-J: ALA28I, ALA31I, ALA62I, ARG325J, ARG40I, ASN142I, ASN63I, ASN67I, ASP29J, ASP327J, ASP328J, ASP38I, ASP68I, CYS139I, CYS27J, CYS66I, GLN39I, GLU33J, GLY26J, GLY33I, GLY60I, HIS140I, HIS56I, HIS61I, ILE64I, LEU34J, LEU58I, LYS149I, LYS329J, LYS330J, LYS35I, LYS57I, MET146I, MET34I, PHE32I, PRO41I, SER28J, SER31J, SER59I, SER65I, THR32J, TYR36I, VAL143I, VAL30J
• I-K: MET122I, THR32K
• I-L: ALA118I, ALA118L, ALA20I, ALA20L, ALA26I, ALA26L, ALA28I, ALA28L, ALA31I, ALA31L, ALA62I, ALA62L, ARG40I, ARG40L, ASN124L, ASN63I, ASN63L, CYS119I, CYS119L, GLY18I, GLY18L, GLY19I, GLY19L, GLY23I, GLY23L, GLY60I, GLY60L, HIS120I, HIS120L, HIS56I, HIS56L, HIS61I, HIS61L, ILE64I, ILE64L, LEU15I, LEU15L, LEU17I, LEU17L, LEU22I, LEU22L, LEU27I, LEU27L, LEU58I, LEU58L, LYS117I, LYS117L, LYS14I, LYS14L, LYS57I, LYS57L, MET122I, MET122L, MET146I, MET146L, SER59I, SER59L, THR121I, THR121L, THR123I, THR123L, THR21I, THR21L, THR29I, THR29L, THR55I, THR55L, VAL125I, VAL125L, VAL16I, VAL16L, VAL24I, VAL24L, VAL25I, VAL25L, VAL30L
• J-K: ALA260K, ALA311J, ALA311K, ALA312J, ALA312K, ALA378J, ALA378K, ALA379J, ALA379K, ALA437J, ALA437K, ALA439J, ALA439K, ALA444J, ALA444K, ALA460K, ARG364J, ARG364K, ARG371J, ARG371K, ASN306J, ASN306K, ASN435J, ASN435K, ASP258J, ASP258K, ASP355J, ASP355K, ASP374J, ASP374K, ASP441J, ASP441K, ASP455J, ASP455K, ASP468J, ASP468K, ASP472J, ASP472K, GLN369J, GLN369K, GLN445J, GLN445K, GLN447J, GLN447K, GLN448J, GLN448K, GLN451J, GLN451K, GLN462J, GLN462K, GLU381J, GLU381K, GLU459J, GLU459K, GLY307J, GLY307K, GLY310J, GLY310K, GLY313J, GLY313K, GLY464J, GLY464K, GLY466J, GLY466K, GLY471J, GLY471K, HIS309J, HIS309K, HIS353J, HIS353K, HIS434J, HIS434K, ILE305J, ILE305K, ILE454J, ILE454K, ILE465J, ILE465K, ILE476K, LEU375J, LEU375K, LEU376J, LEU376K, LEU377J, LEU377K, LEU407J, LEU407K, LEU440J, LEU440K, LEU443J, LEU443K, LEU456J, LEU456K, LEU469J, LEU469K, LYS356J, LYS356K, LYS370J, LYS370K, LYS385J, LYS385K, LYS438J, LYS438K, LYS452J, LYS452K, LYS467J, LYS467K, MET458J, MET458K, PHE367J, PHE367K, PHE449J, PHE449K, PRO259J, PRO259K, PRO436J, PRO436K, SER363J, SER363K, SER446K, SER470J, SER470K, THR303J, THR303K, THR308J, THR308K, THR368J, THR368K, THR372J, THR372K, THR442J, THR442K, TRP304J, TRP304K, TYR360J, TYR360K, TYR463J, TYR463K, VAL314J, VAL314K, VAL382J, VAL382K
• J-L: ALA114L, ALA118L, ALA128L, ALA132L, ALA312J, ALA317J, ALA348J, ARG141L, ARG147L, ARG221J, ARG225J, ARG325J, ARG350J, ASN113L, ASN115L, ASN124L, ASN142L, ASN222J, ASN74L, ASP138L, ASP318J, ASP327J, ASP355J, CYS116L, CYS119L, CYS136L, CYS139L, CYS27J, CYS319J, CYS349J, CYS352J, GLN351J, GLN60J, GLU126L, GLU131L, GLU223J, GLU33J, GLY26J, GLY313J, HIS120L, HIS140L, HIS309J, HIS335J, HIS353J, HIS73L, ILE332J, LEU198J, LEU34J, LEU361J, LEU75L, LYS117L, LYS133L, LYS134L, LYS149L, LYS329J, LYS330J, LYS331J, LYS356J, LYS35J, LYS59J, MET122L, MET130L, MET146L, MET148L, MET224J, PRO150L, PRO220J, PRO37J, SER129L, SER28J, SER31J, SER322J, SER333J, SER334J, SER354J, THR121L, THR123L, THR137L, THR153L, THR315J, THR324J, THR32J, THR36J, TRP304J, TYR323J, TYR39J, VAL125L, VAL127L, VAL143L, VAL30J, VAL314J, VAL38J
• K-L: ALA104L, ALA157L, ALA25K, ALA311K, ALA312K, ALA317K, ALA348K, ALA62L, ARG141L, ARG147L, ARG154L, ARG221K, ARG225K, ARG325K, ARG347K, ARG350K, ARG40L, ASN222K, ASN50L, ASN93L, ASP100L, ASP138L, ASP158L, ASP29K, ASP318K, ASP327K, ASP328K, ASP343K, ASP355K, CYS27K, CYS319K, CYS349K, CYS352K, CYS43L, CYS46L, GLN144L, GLN351K, GLN39L, GLN60K, GLU155L, GLU223K, GLU33K, GLU345K, GLY26K, GLY310K, GLY313K, GLY33L, GLY53L, GLY96L, GLY99L, HIS145L, HIS309K, HIS335K, HIS353K, HIS47L, HIS56L, HIS97L, ILE102L, ILE151L, ILE332K, ILE48L, LEU101L, LEU103L, LEU34K, LEU361K, LEU58L, LEU95L, LYS109L, LYS149L, LYS329K, LYS330K, LYS331K, LYS356K, LYS35K, LYS57L, LYS59K, MET146L, MET148L, MET321K, MET346K, MET49L, MET92L, PHE32L, PHE42L, PRO150L, PRO220K, PRO358K, PRO37K, PRO41L, PRO51L, PRO98L, SER152L, SER28K, SER31K, SER322K, SER326K, SER333K, SER334K, SER354K, SER45L, SER59L, THR137L, THR153L, THR315K, THR324K, THR32K, THR357K, THR36K, THR37L, THR44L, THR55L, THR94L, TRP304K, TYR135L, TYR323K, TYR36L, TYR39K, TYR91L, VAL156L, VAL30K, VAL314K, VAL38K, VAL52L, VAL54L
• M-N: ALA260N, ALA311M, ALA311N, ALA312M, ALA312N, ALA378M, ALA378N, ALA379M, ALA379N, ALA401M, ALA401N, ALA437M, ALA437N, ALA439M, ALA439N, ALA444M, ALA444N, ALA460M, ALA460N, ARG364M, ARG364N, ARG371M, ARG371N, ASN306M, ASN306N, ASN435M, ASN435N, ASP258M, ASP258N, ASP261M, ASP261N, ASP355M, ASP355N, ASP374M, ASP374N, ASP441M, ASP441N, ASP455M, ASP455N, ASP468M, ASP468N, ASP472M, ASP472N, GLN369M, GLN369N, GLN380M, GLN445M, GLN445N, GLN447M, GLN447N, GLN448M, GLN448N, GLN451M, GLN451N, GLN462M, GLN462N, GLU381M, GLU381N, GLU459M, GLU459N, GLY307M, GLY307N, GLY310M, GLY310N, GLY313M, GLY313N, GLY464M, GLY464N, GLY466M, GLY466N, GLY471M, GLY471N, HIS309M, HIS309N, HIS353M, HIS353N, HIS434M, HIS434N, ILE305M, ILE305N, ILE454M, ILE454N, ILE465M, ILE465N, ILE473M, ILE476M, ILE476N, LEU375M, LEU375N, LEU376M, LEU376N, LEU377M, LEU377N, LEU407M, LEU407N, LEU440M, LEU440N, LEU443M, LEU443N, LEU456M, LEU456N, LEU469M, LEU469N, LYS356M, LYS356N, LYS370M, LYS370N, LYS385M, LYS385N, LYS438M, LYS438N, LYS452M, LYS452N, LYS467M, LYS467N, MET458M, MET458N, PHE367M, PHE367N, PHE449M, PHE449N, PRO259M, PRO259N, PRO436M, PRO436N, SER363M, SER363N, SER470M, SER470N, THR303M, THR303N, THR308M, THR308N, THR368M, THR368N, THR372M, THR372N, THR442M, THR442N, TRP304M, TRP304N, TYR360M, TYR360N, TYR463M, TYR463N, VAL314M, VAL314N, VAL382M, VAL382N
• M-O: ALA114O, ALA118O, ALA128O, ALA132O, ALA312M, ALA317M, ALA348M, ARG141O, ARG147O, ARG221M, ARG225M, ARG325M, ARG350M, ASN113O, ASN115O, ASN124O, ASN142O, ASN222M, ASN74O, ASP138O, ASP318M, ASP327M, ASP328M, ASP355M, CYS116O, CYS119O, CYS136O, CYS139O, CYS316M, CYS349M, CYS352M, GLN351M, GLN60M, GLU126O, GLU131O, GLU197M, GLU223M, GLU33M, GLY26M, GLY313M, HIS120O, HIS140O, HIS309M, HIS335M, HIS353M, HIS73O, ILE332M, LEU198M, LEU34M, LEU361M, LEU75O, LYS117O, LYS133O, LYS134O, LYS149O, LYS329M, LYS330M, LYS331M, LYS356M, LYS35M, LYS59M, MET122O, MET130O, MET146O, MET148O, MET224M, PRO150O, PRO220M, PRO37M, SER129O, SER28M, SER31M, SER322M, SER333M, SER334M, SER354M, THR121O, THR123O, THR137O, THR308M, THR315M, THR324M, THR32M, THR36M, TRP304M, TYR323M, TYR39M, VAL125O, VAL127O, VAL143O, VAL30M, VAL314M, VAL38M
• M-P: ALA348P, ALA62M, ALA62P, ARG325M, ARG325P, ARG347M, ARG347P, ARG350M, ARG350P, ARG66M, ARG66P, ARG96M, ARG96P, ASN89M, ASN89P, ASP327M, ASP327P, ASP328M, ASP328P, ASP343M, ASP343P, ASP355M, ASP355P, ASP359M, ASP359P, CYS349P, CYS352M, CYS352P, GLN351M, GLN351P, GLU345M, GLU345P, GLU65M, GLU65P, GLU69M, GLU69P, GLU75M, GLU75P, GLU93M, GLU93P, HIS353M, HIS353P, ILE332P, LEU91M, LEU91P, LYS329M, LYS329P, LYS330M, LYS330P, LYS342M, LYS342P, LYS356M, LYS356P, LYS362M, LYS362P, LYS59M, LYS59P, MET341M, MET341P, MET346M, MET346P, MET73M, MET73P, PRO340P, PRO344M, PRO344P, PRO358M, PRO358P, PRO58M, PRO58P, PRO90M, PRO90P, PRO92M, PRO92P, SER322P, SER326M, SER326P, SER334M, SER334P, SER339M, SER339P, SER354M, SER354P, SER63M, SER63P, THR324M, THR324P, THR338M, THR338P, THR357M, THR357P, THR70M, THR71M, THR71P, THR74M, THR74P, TRP336M, TRP336P, TYR323M, TYR323P, TYR360M, TYR360P, TYR95M, TYR95P, VAL72M, VAL72P
• M-Q: ASP29M, ASP29Q, HIS1M, HIS1Q, SER31M, THR32M, THR32Q, VAL30Q
• M-R: ARG40R, ASN63R, ASP29M, ASP328M, ASP38R, ASP68R, LYS149R, LYS35R, THR32M
• N-O: ALA104O, ALA157O, ALA25N, ALA312N, ALA317N, ALA348N, ALA62O, ARG141O, ARG147O, ARG154O, ARG221N, ARG225N, ARG325N, ARG347N, ARG350N, ARG40O, ASN222N, ASN50O, ASN93O, ASP100O, ASP138O, ASP158O, ASP29N, ASP318N, ASP327N, ASP328N, ASP343N, ASP355N, ASP89O, CYS27N, CYS319N, CYS349N, CYS352N, CYS43O, CYS46O, GLN144O, GLN351N, GLN39O, GLN60N, GLU155O, GLU223N, GLU33N, GLU345N, GLY26N, GLY310N, GLY313N, GLY33O, GLY53O, GLY96O, GLY99O, HIS309N, HIS335N, HIS353N, HIS47O, HIS56O, HIS97O, ILE102O, ILE151O, ILE332N, ILE48O, LEU101O, LEU103O, LEU34N, LEU361N, LEU58O, LEU95O, LYS109O, LYS149O, LYS329N, LYS330N, LYS331N, LYS356N, LYS35N, LYS57O, LYS59N, MET146O, MET148O, MET321N, MET346N, MET49O, MET92O, PHE32O, PHE42O, PRO150O, PRO220N, PRO358N, PRO37N, PRO41O, PRO51O, PRO98O, SER152O, SER28N, SER31N, SER322N, SER326N, SER333N, SER334N, SER354N, SER45O, SER59O, THR137O, THR153O, THR315N, THR324N, THR32N, THR36N, THR37O, THR44O, THR55O, THR94O, TRP304N, TYR135O, TYR323N, TYR36O, TYR39N, TYR91O, VAL156O, VAL30N, VAL314N, VAL52O, VAL54O, VAL90O
• N-P: ALA378P, ALA379P, ALA386P, ASP29N, ASP472P, GLN380P, GLN447P, GLN451P, GLU381P, HIS1N, ILE454P, ILE473P, LEU377P, LYS218N, LYS385P, LYS42P, SER31P, SER383P, THR32N, THR32P, TYR101P, VAL30N, VAL382P, VAL384P
• O-P: ALA28O, ALA31O, ALA62O, ARG141O, ARG325P, ARG40O, ASN142O, ASN63O, ASP29P, ASP327P, ASP328P, ASP38O, ASP68O, CYS139O, CYS27P, CYS66O, GLN39O, GLU33P, GLY26P, GLY33O, GLY60O, HIS140O, HIS56O, HIS61O, ILE64O, LEU34P, LEU58O, LYS149O, LYS329P, LYS330P, LYS35O, LYS57O, MET146O, MET34O, PHE32O, PRO41O, SER28P, SER31P, SER59O, SER65O, THR32P, TYR36O, VAL143O, VAL30P
• O-Q: MET122O, THR32Q
• P-Q: ARG371P, ARG371Q, ASP374P, ASP374Q, ASP441P, ASP441Q, ASP455Q, GLN447Q, GLN448P, GLY466P, LYS370P, LYS370Q, LYS385P, LYS438P, LYS438Q, TYR463Q
• P-R: ARG141R, ARG147R, ARG221P, ARG225P, ASN124R, ASN222P, ASP138R, ASP318P, ASP327P, ASP355P, GLU126R, GLU131R, GLU33P, GLY313P, HIS353P, LYS117R, LYS133R, LYS149R, LYS330P, LYS331P, LYS356P, LYS59P, THR123R
• Q-R: ARG141R, ARG147R, ARG154R, ARG221Q, ARG325Q, ARG347Q, ARG350Q, ARG40R, ASP100R, ASP138R, ASP158R, ASP29Q, ASP318Q, ASP328Q, ASP343Q, ASP355Q, GLN351Q, GLU155R, GLY99R, HIS353Q, HIS47R, HIS97R, ILE151R, LYS329Q, LYS330Q, LYS331Q, LYS57R, SER152R, THR324Q, VAL156R, VAL30Q