2J5G

the native structure of a beta-diketone hydrolase from the cyanobacterium anabaena sp. pcc 7120

• Total interactions analyzed: 66
• Total true interactions: 34
• Strongest Interaction:
  • Chains: H-K
  • Int. Res.: 118
  • Norm. En. per Res.: -4.888
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-37.8179	-33.8749	-406.716	-478.4088	126	17	17	16426	3	24	29
A-C	-42.9947	-32.8199	-384.014	-459.8286	123	12	17	15415	3	24	29
A-D	-71.1587	-198.5785	-292.747	-562.4843	116	10	0	11098	16	70	80
A-E	-24.2041	-41.9589	-147.887	-214.05	59	7	9	5589	4	13	14
A-F	0.0	0.0	-0.0552	-0.0552	4	0	0	7	0	0	3
A-J	0.0	0.0	-0.0029	-0.0029	4	0	0	5	0	2	1
B-C	-34.8588	-36.5861	-384.789	-456.2339	125	8	17	15578	3	24	29
B-D	0.0	0.0	-0.0551	-0.0551	4	0	0	7	0	0	3
B-E	-75.6451	-199.3919	-294.654	-569.691	118	13	0	11125	16	70	83
B-F	-28.8459	-43.5527	-143.267	-215.6655	58	7	9	5418	4	13	14
B-K	0.0	0.0	-1.1013	-1.1013	6	0	0	134	0	3	3
B-L	-20.4327	-2.8242	-73.8787	-97.1357	44	2	0	3104	0	8	9
C-D	-29.364	-43.6086	-143.216	-216.1886	59	7	9	5440	4	13	14
C-E	0.0	0.0	-0.0577	-0.0577	4	0	0	6	0	0	3
C-F	-72.8436	-200.3188	-297.209	-570.3714	120	13	0	11183	16	70	83
C-L	0.0	-3.7054	-3.3911	-7.0965	6	0	0	284	0	3	3
D-E	-31.5179	-33.1316	-384.488	-449.1375	127	12	17	15517	3	24	29
D-F	-31.0514	-38.2368	-410.539	-479.8272	127	13	17	16533	3	24	28
E-F	-29.4018	-35.9163	-407.031	-472.3491	125	13	17	16409	3	24	29
G-H	-40.5654	-35.9583	-404.131	-480.6547	125	13	17	16280	3	24	28
G-I	-39.7526	-36.0409	-378.701	-454.4945	124	11	17	15353	3	25	29
G-J	-64.1696	-197.8974	-292.352	-554.419	117	10	0	11065	16	70	82
G-K	-25.9166	-42.9502	-140.008	-208.8747	58	6	9	5259	4	13	14
G-L	0.0	0.0	-0.0536	-0.0536	4	0	0	7	0	0	3
H-I	-36.3611	-35.785	-405.711	-477.8571	125	13	17	16476	3	24	27
H-J	0.0	0.0	-0.0542	-0.0542	4	0	0	6	0	0	3
H-K	-72.0573	-202.3673	-302.359	-576.7836	118	14	0	11187	16	71	82
H-L	-24.3545	-36.3055	-142.401	-203.0611	58	5	9	5540	4	13	14
I-J	-32.2643	-42.9329	-147.825	-223.0222	58	4	9	5598	4	14	14
I-K	0.0	0.0	-0.0575	-0.0575	4	0	0	6	0	0	3
I-L	-68.7767	-197.7451	-300.093	-566.6149	122	13	0	11240	16	72	82
J-K	-30.0815	-35.0368	-403.069	-468.1873	126	10	17	16318	3	24	28
J-L	-29.6318	-35.4191	-411.167	-476.2178	125	11	17	16489	3	24	28
K-L	-29.9116	-35.3155	-405.143	-470.3701	126	10	17	16370	3	24	29

Interface residues

• A-B: ALA147A, ALA162A, ALA162B, ALA183B, ALA206B, ALA223B, ALA241A, ALA247A, ARG167A, ARG169A, ARG201B, ARG218B, ARG221B, ARG227A, ARG227B, ARG230A, ARG230B, ASN146A, ASN187A, ASN187B, ASN216B, ASN233A, ASN252A, ASP129B, ASP141A, ASP153A, ASP249A, GLN175A, GLN182A, GLN212B, GLN226B, GLU107B, GLU123B, GLU176A, GLU185A, GLU185B, GLU191B, GLU234A, GLU243A, GLY148A, GLY152A, GLY154A, GLY164A, GLY164B, GLY168A, GLY235A, GLY237A, GLY239A, GLY244A, HIS144A, HIS156A, HIS190B, ILE111B, ILE125B, ILE130B, ILE131B, ILE149A, ILE157A, ILE157B, ILE205B, ILE236A, ILE245A, LEU104B, LEU126B, LEU132B, LEU145A, LEU158A, LEU158B, LEU161A, LEU161B, LEU163A, LEU163B, LEU165A, LEU165B, LEU172A, LEU178A, LEU186A, LEU186B, LEU193B, LEU209B, LEU215B, LEU217B, LEU224B, LEU228B, LEU231A, LEU231B, LEU240A, LEU242A, LEU250A, LYS211B, LYS229B, PHE171A, PHE173A, PRO109B, PRO143A, PRO151A, PRO160A, PRO160B, PRO213B, THR127B, THR128B, THR174A, THR208B, THR214B, THR220B, THR225B, THR246A, THR248A, TRP159A, TRP159B, TYR124B, TYR166A, TYR170A, TYR184B, TYR219B, TYR238A, VAL108B, VAL110B, VAL150A, VAL155A, VAL188B, VAL189B, VAL222B, VAL232A, VAL232B, VAL61B
• A-C: ALA147C, ALA162A, ALA162C, ALA223A, ALA241C, ALA247C, ARG167C, ARG169C, ARG201A, ARG218A, ARG221A, ARG227A, ARG227C, ARG230A, ARG230C, ASN146C, ASN187A, ASN187C, ASN216A, ASN233C, ASN252C, ASP129A, ASP141C, ASP153C, ASP249C, GLN175C, GLN182C, GLN212A, GLN226A, GLU107A, GLU123A, GLU176C, GLU185A, GLU185C, GLU191A, GLU234C, GLU243C, GLY148C, GLY152C, GLY154C, GLY164A, GLY164C, GLY168C, GLY235C, GLY237C, GLY239C, GLY244C, HIS144C, HIS156C, HIS190A, ILE111A, ILE125A, ILE130A, ILE131A, ILE149C, ILE157A, ILE157C, ILE205A, ILE236C, ILE245C, LEU104A, LEU126A, LEU132A, LEU145C, LEU158A, LEU158C, LEU161A, LEU161C, LEU163A, LEU163C, LEU165A, LEU165C, LEU172C, LEU186A, LEU186C, LEU193A, LEU209A, LEU215A, LEU217A, LEU224A, LEU228A, LEU231A, LEU231C, LEU240C, LEU242C, LEU250C, LYS211A, LYS229A, PHE171C, PHE173C, PRO109A, PRO143C, PRO151C, PRO160A, PRO160C, PRO213A, THR127A, THR128A, THR174C, THR208A, THR214A, THR220A, THR225A, THR246C, THR248C, TRP159A, TRP159C, TYR124A, TYR166C, TYR170C, TYR184A, TYR219A, TYR238C, VAL108A, VAL110A, VAL150C, VAL155C, VAL188A, VAL189A, VAL222A, VAL232A, VAL232C, VAL61A
• A-D: ALA223A, ALA223D, ALA241A, ALA241D, ARG218A, ARG218D, ARG221A, ARG221D, ARG230A, ARG230D, ARG44A, ARG44D, ARG55A, ARG55D, ARG57A, ARG57D, ARG60A, ARG87A, ARG87D, ASN102A, ASN102D, ASN216A, ASN216D, ASN233A, ASN233D, ASN85A, ASN85D, ASP105A, ASP105D, ASP48A, ASP48D, ASP52A, ASP52D, ASP56A, ASP56D, ASP90A, ASP90D, GLN101A, GLN101D, GLN226A, GLN226D, GLU107A, GLU107D, GLU234A, GLU234D, GLU45A, GLU45D, GLU88A, GLU88D, GLU95A, GLU95D, GLY235A, GLY235D, GLY237A, GLY237D, GLY244A, GLY244D, ILE106A, ILE106D, ILE245A, ILE245D, ILE53A, ILE53D, LEU100D, LEU103A, LEU103D, LEU104A, LEU104D, LEU215A, LEU215D, LEU240A, LEU240D, LYS11A, LYS11D, LYS229A, LYS229D, LYS91A, LYS91D, LYS97A, LYS97D, LYS98A, LYS98D, PHE50A, PHE50D, PRO213A, PRO213D, PRO47A, PRO47D, PRO86A, PRO86D, SER54A, SER54D, THR214A, THR214D, THR225A, THR225D, THR92A, THR92D, TRP89A, TRP89D, TRP94A, TRP94D, TYR12A, TYR12D, TYR219A, TYR219D, TYR238A, TYR238D, TYR51A, TYR51D, TYR93A, TYR93D, VAL222A, VAL222D, VAL99A, VAL99D
• A-E: ALA241A, ALA241E, ALA247A, ALA247E, ARG251A, ARG251E, ARG87A, ARG87E, ASN233A, ASN233E, ASN252A, ASN252E, ASN85A, ASN85E, ASP249A, ASP249E, ASP90A, ASP90E, GLU234A, GLU234E, GLU243A, GLU243E, GLU88A, GLU88E, GLY235A, GLY235E, GLY237A, GLY237E, GLY239A, GLY239E, GLY244A, GLY244E, ILE236A, ILE236E, ILE245A, ILE245E, LEU240A, LEU240E, LEU242A, LEU242E, LEU250A, LEU250E, LYS97A, LYS97E, PRO86A, PRO86E, THR246A, THR246E, THR248A, THR248E, THR253E, THR84A, THR84E, TRP89A, TRP89E, TYR238A, TYR238E, TYR93A, TYR93E
• A-F: ARG230A, ARG230F, GLN226A, GLN226F
• A-J: GLU135A, LYS177J, THR179A, THR179J
• B-C: ALA147B, ALA162B, ALA162C, ALA206C, ALA223C, ALA241B, ALA247B, ARG167B, ARG169B, ARG201C, ARG218C, ARG221C, ARG227B, ARG227C, ARG230B, ARG230C, ASN146B, ASN187B, ASN187C, ASN216C, ASN233B, ASN252B, ASP129C, ASP141B, ASP153B, ASP249B, GLN175B, GLN182B, GLN212C, GLN226C, GLU107C, GLU123C, GLU176B, GLU185B, GLU185C, GLU191C, GLU234B, GLU243B, GLY148B, GLY152B, GLY154B, GLY164B, GLY164C, GLY168B, GLY235B, GLY237B, GLY239B, GLY244B, HIS144B, HIS156B, HIS190C, ILE111C, ILE125C, ILE130C, ILE131C, ILE149B, ILE157B, ILE157C, ILE205C, ILE236B, ILE245B, LEU104C, LEU126C, LEU132C, LEU145B, LEU158B, LEU158C, LEU161B, LEU161C, LEU163B, LEU163C, LEU165B, LEU165C, LEU172B, LEU186B, LEU186C, LEU193C, LEU209C, LEU215C, LEU217C, LEU224C, LEU228C, LEU231B, LEU231C, LEU240B, LEU242B, LEU250B, LYS211C, LYS229C, PHE171B, PHE173B, PRO109C, PRO143B, PRO151B, PRO160B, PRO160C, PRO213C, SER122C, THR127C, THR128C, THR174B, THR208C, THR214C, THR220C, THR225C, THR246B, THR248B, TRP159B, TRP159C, TYR124C, TYR166B, TYR170B, TYR184C, TYR219C, TYR238B, VAL108C, VAL110C, VAL150B, VAL155B, VAL188C, VAL189C, VAL222C, VAL232B, VAL232C, VAL61C
• B-D: ARG230B, ARG230D, GLN226B, GLN226D
• B-E: ALA223B, ALA223E, ALA241B, ALA241E, ARG218B, ARG218E, ARG221B, ARG221E, ARG227B, ARG230B, ARG230E, ARG44B, ARG44E, ARG55B, ARG55E, ARG57B, ARG57E, ARG60B, ARG60E, ARG87B, ARG87E, ASN102B, ASN102E, ASN216B, ASN216E, ASN233B, ASN233E, ASN85B, ASN85E, ASP105B, ASP105E, ASP48B, ASP48E, ASP52B, ASP52E, ASP56B, ASP56E, ASP90B, ASP90E, GLN101B, GLN101E, GLN226B, GLN226E, GLU107B, GLU107E, GLU234B, GLU234E, GLU45B, GLU45E, GLU88B, GLU88E, GLU95B, GLU95E, GLY235B, GLY235E, GLY237B, GLY237E, GLY244B, GLY244E, ILE106B, ILE106E, ILE245B, ILE245E, ILE53B, ILE53E, LEU103B, LEU103E, LEU104B, LEU104E, LEU215B, LEU215E, LEU231B, LEU240B, LEU240E, LYS11B, LYS11E, LYS229B, LYS229E, LYS91B, LYS91E, LYS97B, LYS97E, LYS98B, LYS98E, PHE50B, PHE50E, PRO213B, PRO213E, PRO47B, PRO47E, PRO86B, PRO86E, SER54B, SER54E, THR214B, THR214E, THR225B, THR225E, THR92B, THR92E, TRP89B, TRP89E, TRP94B, TRP94E, TYR12B, TYR12E, TYR219B, TYR219E, TYR238B, TYR238E, TYR51B, TYR51E, TYR93B, TYR93E, VAL222B, VAL222E, VAL99B, VAL99E
• B-F: ALA241B, ALA241F, ALA247B, ALA247F, ARG251B, ARG251F, ARG87B, ARG87F, ASN233B, ASN233F, ASN252B, ASN252F, ASN85B, ASN85F, ASP249B, ASP249F, ASP90B, ASP90F, GLU234B, GLU234F, GLU243B, GLU243F, GLU88B, GLU88F, GLY235B, GLY235F, GLY237B, GLY237F, GLY239B, GLY239F, GLY244B, GLY244F, ILE236B, ILE236F, ILE245B, ILE245F, LEU240B, LEU240F, LEU242B, LEU242F, LEU250B, LEU250F, LYS97B, LYS97F, PRO86B, PRO86F, THR246B, THR246F, THR248B, THR248F, THR84B, THR84F, TRP89B, TRP89F, TYR238B, TYR238F, TYR93B, TYR93F
• B-K: GLN181K, GLU185K, GLU200B, LYS197B, SER196B, TYR184K
• B-L: ALA133B, ALA133L, ALA180B, ALA180L, ALA183B, ALA183L, ARG167B, ASN136B, ASN136L, GLN181B, GLN181L, GLN182B, GLN182L, GLN195B, GLN195L, GLU135B, GLU135L, GLU185B, GLU185L, GLU191B, LEU178B, LEU178L, LEU186B, LEU186L, LEU193B, LEU193L, LYS197B, LYS197L, PRO194B, PRO194L, SER134B, SER134L, SER196B, SER196L, THR137B, THR137L, THR179B, THR179L, TYR184B, TYR184L, VAL138B, VAL138L, VAL192B, VAL192L
• C-D: ALA241C, ALA241D, ALA247C, ALA247D, ARG251C, ARG251D, ARG87C, ARG87D, ASN233C, ASN233D, ASN252C, ASN252D, ASN253D, ASN85C, ASN85D, ASP249C, ASP249D, ASP90C, ASP90D, GLU234C, GLU234D, GLU243C, GLU243D, GLU88C, GLU88D, GLY235C, GLY235D, GLY237C, GLY237D, GLY239C, GLY239D, GLY244C, GLY244D, ILE236C, ILE236D, ILE245C, ILE245D, LEU240C, LEU240D, LEU242C, LEU242D, LEU250C, LEU250D, LYS97C, LYS97D, PRO86C, PRO86D, THR246C, THR246D, THR248C, THR248D, THR84C, THR84D, TRP89C, TRP89D, TYR238C, TYR238D, TYR93C, TYR93D
• C-E: ARG230C, ARG230E, GLN226C, GLN226E
• C-F: ALA223C, ALA223F, ALA241C, ALA241F, ALA49C, ARG218C, ARG218F, ARG221C, ARG221F, ARG230C, ARG230F, ARG44C, ARG44F, ARG55C, ARG55F, ARG57C, ARG57F, ARG60C, ARG60F, ARG87C, ARG87F, ASN102C, ASN102F, ASN216C, ASN216F, ASN233C, ASN233F, ASN85C, ASN85F, ASP105C, ASP105F, ASP48C, ASP48F, ASP52C, ASP52F, ASP56C, ASP56F, ASP90C, ASP90F, GLN101C, GLN101F, GLN212F, GLN226C, GLN226F, GLU107C, GLU107F, GLU234C, GLU234F, GLU45C, GLU45F, GLU88C, GLU88F, GLU95C, GLU95F, GLY235C, GLY235F, GLY237C, GLY237F, GLY244C, GLY244F, ILE106C, ILE106F, ILE245C, ILE245F, ILE53C, ILE53F, LEU103C, LEU103F, LEU104C, LEU104F, LEU215C, LEU215F, LEU240C, LEU240F, LYS11C, LYS11F, LYS229C, LYS229F, LYS91C, LYS91F, LYS97C, LYS97F, LYS98C, LYS98F, PHE46C, PHE50C, PHE50F, PRO213C, PRO213F, PRO47C, PRO47F, PRO86C, PRO86F, SER54C, SER54F, THR214C, THR214F, THR225C, THR225F, THR92C, THR92F, TRP89C, TRP89F, TRP94C, TRP94F, TYR12C, TYR12F, TYR219C, TYR219F, TYR238C, TYR238F, TYR51C, TYR51F, TYR93C, TYR93F, VAL222C, VAL222F, VAL232C, VAL99C, VAL99F
• C-L: GLN181C, GLU185C, GLU200L, LYS197L, SER196L, TYR184C
• D-E: ALA147E, ALA162D, ALA162E, ALA183D, ALA206D, ALA223D, ALA241E, ALA247E, ARG167E, ARG169E, ARG201D, ARG218D, ARG221D, ARG227D, ARG227E, ARG230D, ARG230E, ASN146E, ASN187D, ASN187E, ASN216D, ASN233E, ASN252E, ASP129D, ASP141E, ASP153E, ASP249E, GLN175E, GLN182E, GLN212D, GLN226D, GLU107D, GLU123D, GLU176E, GLU185D, GLU185E, GLU191D, GLU234E, GLU243E, GLY148E, GLY152E, GLY154E, GLY164D, GLY164E, GLY168E, GLY235E, GLY237E, GLY239E, GLY244E, HIS144E, HIS156E, HIS190D, ILE111D, ILE125D, ILE130D, ILE131D, ILE149E, ILE157D, ILE157E, ILE205D, ILE236E, ILE245E, LEU104D, LEU126D, LEU132D, LEU145E, LEU158D, LEU158E, LEU161D, LEU161E, LEU163D, LEU163E, LEU165D, LEU165E, LEU172E, LEU186D, LEU186E, LEU193D, LEU209D, LEU215D, LEU217D, LEU224D, LEU228D, LEU231D, LEU231E, LEU240E, LEU242E, LEU250E, LYS211D, LYS229D, PHE171E, PHE173E, PRO109D, PRO143E, PRO151E, PRO160D, PRO160E, PRO213D, SER112D, THR127D, THR128D, THR174E, THR208D, THR214D, THR220D, THR225D, THR246E, THR248E, THR253E, TRP159D, TRP159E, TYR124D, TYR166E, TYR170E, TYR184D, TYR219D, TYR238E, VAL108D, VAL110D, VAL150E, VAL155E, VAL188D, VAL189D, VAL222D, VAL232D, VAL232E, VAL61D
• D-F: ALA147D, ALA162D, ALA162F, ALA183F, ALA206F, ALA223F, ALA241D, ALA247D, ARG167D, ARG169D, ARG201F, ARG218F, ARG221F, ARG227D, ARG227F, ARG230D, ARG230F, ASN146D, ASN187D, ASN187F, ASN216F, ASN233D, ASN252D, ASN253D, ASP129F, ASP141D, ASP153D, ASP249D, GLN175D, GLN182D, GLN212F, GLN226F, GLU107F, GLU123F, GLU176D, GLU185D, GLU185F, GLU191F, GLU234D, GLU243D, GLY148D, GLY152D, GLY154D, GLY164D, GLY164F, GLY168D, GLY235D, GLY237D, GLY239D, GLY244D, HIS144D, HIS156D, HIS190F, ILE111F, ILE125F, ILE130F, ILE131F, ILE149D, ILE157D, ILE157F, ILE205F, ILE236D, ILE245D, LEU104F, LEU126F, LEU132F, LEU145D, LEU158D, LEU158F, LEU161D, LEU161F, LEU163D, LEU163F, LEU165D, LEU165F, LEU172D, LEU178D, LEU186D, LEU186F, LEU193F, LEU209F, LEU215F, LEU217F, LEU224F, LEU228F, LEU231D, LEU231F, LEU240D, LEU242D, LEU250D, LYS211F, LYS229F, PHE171D, PHE173D, PRO109F, PRO143D, PRO151D, PRO160D, PRO160F, PRO213F, THR127F, THR128F, THR174D, THR208F, THR214F, THR220F, THR225F, THR246D, THR248D, TRP159D, TRP159F, TYR124F, TYR166D, TYR170D, TYR184F, TYR219F, TYR238D, VAL108F, VAL110F, VAL150D, VAL155D, VAL188F, VAL189F, VAL222F, VAL232D, VAL232F, VAL61F
• E-F: ALA147F, ALA162E, ALA162F, ALA206E, ALA223E, ALA241F, ALA247F, ARG167F, ARG169F, ARG201E, ARG218E, ARG221E, ARG227E, ARG227F, ARG230E, ARG230F, ASN146F, ASN187E, ASN187F, ASN216E, ASN233F, ASN252F, ASP129E, ASP141F, ASP153F, ASP249F, GLN175F, GLN182F, GLN212E, GLN226E, GLU107E, GLU123E, GLU176F, GLU185E, GLU185F, GLU191E, GLU234F, GLU243F, GLY148F, GLY152F, GLY154F, GLY164E, GLY164F, GLY168F, GLY235F, GLY237F, GLY239F, GLY244F, HIS144F, HIS156F, HIS190E, ILE111E, ILE125E, ILE130E, ILE131E, ILE149F, ILE157E, ILE157F, ILE205E, ILE236F, ILE245F, LEU104E, LEU126E, LEU132E, LEU145F, LEU158E, LEU158F, LEU161E, LEU161F, LEU163E, LEU163F, LEU165E, LEU165F, LEU172F, LEU186E, LEU186F, LEU193E, LEU209E, LEU215E, LEU217E, LEU224E, LEU228E, LEU231E, LEU231F, LEU240F, LEU242F, LEU250F, LYS211E, LYS229E, PHE171F, PHE173F, PRO109E, PRO143F, PRO151F, PRO160E, PRO160F, PRO213E, THR127E, THR128E, THR174F, THR208E, THR214E, THR220E, THR225E, THR246F, THR248F, TRP159E, TRP159F, TYR124E, TYR166F, TYR170F, TYR184E, TYR219E, TYR238F, VAL108E, VAL110E, VAL150F, VAL155F, VAL188E, VAL189E, VAL192E, VAL222E, VAL232E, VAL232F, VAL61E
• G-H: ALA147G, ALA162G, ALA162H, ALA206H, ALA223H, ALA241G, ALA247G, ARG167G, ARG169G, ARG201H, ARG218H, ARG221H, ARG227G, ARG227H, ARG230G, ARG230H, ASN146G, ASN187G, ASN187H, ASN216H, ASN233G, ASN252G, ASP129H, ASP141G, ASP153G, ASP249G, GLN175G, GLN182G, GLN212H, GLN226H, GLU107H, GLU123H, GLU176G, GLU185G, GLU185H, GLU191H, GLU234G, GLU243G, GLY148G, GLY152G, GLY154G, GLY164G, GLY164H, GLY168G, GLY235G, GLY237G, GLY239G, GLY244G, HIS144G, HIS156G, HIS190H, ILE111H, ILE125H, ILE130H, ILE131H, ILE149G, ILE157G, ILE157H, ILE205H, ILE236G, ILE245G, LEU104H, LEU126H, LEU132H, LEU145G, LEU158G, LEU158H, LEU161G, LEU161H, LEU163G, LEU163H, LEU165G, LEU165H, LEU172G, LEU186G, LEU186H, LEU193H, LEU209H, LEU215H, LEU217H, LEU224H, LEU228H, LEU231G, LEU231H, LEU240G, LEU242G, LEU250G, LYS211H, LYS229H, PHE171G, PHE173G, PRO109H, PRO143G, PRO151G, PRO160G, PRO160H, PRO213H, SER112H, THR127H, THR128H, THR174G, THR208H, THR214H, THR220H, THR225H, THR246G, THR248G, TRP159G, TRP159H, TYR124H, TYR166G, TYR170G, TYR184H, TYR219H, TYR238G, VAL108H, VAL110H, VAL150G, VAL155G, VAL188H, VAL189H, VAL222H, VAL232G, VAL232H, VAL61H
• G-I: ALA147I, ALA162G, ALA162I, ALA223G, ALA241I, ALA247I, ARG167I, ARG169I, ARG201G, ARG218G, ARG221G, ARG227G, ARG227I, ARG230G, ARG230I, ASN146I, ASN187G, ASN187I, ASN216G, ASN233I, ASN252I, ASP129G, ASP141I, ASP153I, ASP249I, GLN175I, GLN182I, GLN212G, GLN226G, GLU107G, GLU123G, GLU176I, GLU185G, GLU185I, GLU191G, GLU234I, GLU243I, GLY148I, GLY152I, GLY154I, GLY164G, GLY164I, GLY168I, GLY235I, GLY237I, GLY239I, GLY244I, HIS144I, HIS156I, HIS190G, ILE111G, ILE125G, ILE130G, ILE131G, ILE149I, ILE157G, ILE157I, ILE205G, ILE236I, ILE245I, LEU104G, LEU126G, LEU132G, LEU145I, LEU158G, LEU158I, LEU161G, LEU161I, LEU163G, LEU163I, LEU165G, LEU165I, LEU172I, LEU186G, LEU186I, LEU193G, LEU209G, LEU215G, LEU217G, LEU224G, LEU228G, LEU231G, LEU231I, LEU240I, LEU242I, LEU250I, LYS211G, LYS229G, PHE171I, PHE173I, PRO109G, PRO143I, PRO151I, PRO160G, PRO160I, PRO213G, SER122G, THR127G, THR128G, THR174I, THR208G, THR214G, THR220G, THR225G, THR246I, THR248I, TRP159G, TRP159I, TYR124G, TYR166I, TYR170I, TYR184G, TYR219G, TYR238I, VAL108G, VAL110G, VAL150I, VAL155I, VAL188G, VAL189G, VAL222G, VAL232G, VAL232I, VAL61G
• G-J: ALA223G, ALA223J, ALA241G, ALA241J, ARG218G, ARG218J, ARG221G, ARG221J, ARG227G, ARG230G, ARG230J, ARG44G, ARG44J, ARG55G, ARG55J, ARG57G, ARG57J, ARG60G, ARG87G, ARG87J, ASN102G, ASN102J, ASN216G, ASN216J, ASN233G, ASN233J, ASN85G, ASN85J, ASP105G, ASP105J, ASP48G, ASP48J, ASP52G, ASP52J, ASP56G, ASP56J, ASP90G, ASP90J, GLN101G, GLN101J, GLN226G, GLN226J, GLU107G, GLU107J, GLU234G, GLU234J, GLU45G, GLU45J, GLU88G, GLU88J, GLU95G, GLU95J, GLY235G, GLY235J, GLY237G, GLY237J, GLY244G, GLY244J, ILE106G, ILE106J, ILE245G, ILE245J, ILE53G, ILE53J, LEU103G, LEU103J, LEU104G, LEU104J, LEU215G, LEU215J, LEU231G, LEU240G, LEU240J, LYS11G, LYS11J, LYS229G, LYS229J, LYS91G, LYS91J, LYS97G, LYS97J, LYS98G, LYS98J, PHE50G, PHE50J, PRO213G, PRO213J, PRO47G, PRO47J, PRO86G, PRO86J, SER54G, SER54J, THR214G, THR214J, THR225G, THR225J, THR92G, THR92J, TRP89G, TRP89J, TRP94G, TRP94J, TYR12G, TYR12J, TYR219G, TYR219J, TYR238G, TYR238J, TYR51G, TYR51J, TYR93G, TYR93J, VAL222G, VAL222J, VAL99G, VAL99J
• G-K: ALA241G, ALA241K, ALA247G, ALA247K, ARG251G, ARG251K, ARG87G, ARG87K, ASN233G, ASN233K, ASN252G, ASN252K, ASN85G, ASN85K, ASP249G, ASP249K, ASP90G, ASP90K, GLU234G, GLU234K, GLU243G, GLU243K, GLU88G, GLU88K, GLY235G, GLY235K, GLY237G, GLY237K, GLY239G, GLY239K, GLY244G, GLY244K, ILE236G, ILE236K, ILE245G, ILE245K, LEU240G, LEU240K, LEU242G, LEU242K, LEU250G, LEU250K, LYS97G, LYS97K, PRO86G, PRO86K, THR246G, THR246K, THR248G, THR248K, THR84G, THR84K, TRP89G, TRP89K, TYR238G, TYR238K, TYR93G, TYR93K
• G-L: ARG230G, ARG230L, GLN226G, GLN226L
• H-I: ALA147H, ALA162H, ALA162I, ALA206I, ALA223I, ALA241H, ALA247H, ARG167H, ARG169H, ARG201I, ARG218I, ARG221I, ARG227H, ARG227I, ARG230H, ARG230I, ASN146H, ASN187H, ASN187I, ASN216I, ASN233H, ASN252H, ASP129I, ASP141H, ASP153H, ASP249H, GLN175H, GLN182H, GLN212I, GLN226I, GLU107I, GLU123I, GLU176H, GLU185H, GLU185I, GLU191I, GLU234H, GLU243H, GLY148H, GLY152H, GLY154H, GLY164H, GLY164I, GLY168H, GLY235H, GLY237H, GLY239H, GLY244H, HIS144H, HIS156H, HIS190I, ILE111I, ILE125I, ILE130I, ILE131I, ILE149H, ILE157H, ILE157I, ILE205I, ILE236H, ILE245H, LEU104I, LEU126I, LEU132I, LEU145H, LEU158H, LEU158I, LEU161H, LEU161I, LEU163H, LEU163I, LEU165H, LEU165I, LEU172H, LEU186H, LEU186I, LEU193I, LEU209I, LEU215I, LEU217I, LEU224I, LEU228I, LEU231H, LEU231I, LEU240H, LEU242H, LEU250H, LYS211I, LYS229I, PHE171H, PHE173H, PRO109I, PRO143H, PRO151H, PRO160H, PRO160I, PRO213I, SER122I, THR127I, THR128I, THR174H, THR208I, THR214I, THR220I, THR225I, THR246H, THR248H, TRP159H, TRP159I, TYR124I, TYR166H, TYR170H, TYR184I, TYR219I, TYR238H, VAL108I, VAL110I, VAL150H, VAL155H, VAL188I, VAL189I, VAL222I, VAL232H, VAL232I, VAL61I
• H-J: ARG230H, ARG230J, GLN226H, GLN226J
• H-K: ALA223H, ALA223K, ALA241H, ALA241K, ARG218H, ARG218K, ARG221H, ARG221K, ARG227H, ARG230H, ARG230K, ARG44H, ARG44K, ARG55H, ARG55K, ARG57H, ARG57K, ARG87H, ARG87K, ASN102H, ASN102K, ASN216H, ASN216K, ASN233H, ASN233K, ASN85H, ASN85K, ASP105H, ASP105K, ASP48H, ASP48K, ASP52H, ASP52K, ASP56H, ASP56K, ASP90H, ASP90K, GLN101H, GLN101K, GLN226H, GLN226K, GLU107H, GLU107K, GLU234H, GLU234K, GLU45H, GLU45K, GLU88H, GLU88K, GLU95H, GLU95K, GLY235H, GLY235K, GLY237H, GLY237K, GLY244H, GLY244K, ILE106H, ILE106K, ILE245H, ILE245K, ILE53H, ILE53K, LEU100H, LEU103H, LEU103K, LEU104H, LEU104K, LEU215H, LEU215K, LEU231H, LEU240K, LYS11H, LYS11K, LYS229H, LYS229K, LYS91H, LYS91K, LYS97H, LYS97K, LYS98H, LYS98K, PHE50H, PHE50K, PRO213H, PRO213K, PRO47H, PRO47K, PRO86H, PRO86K, SER54H, SER54K, THR214H, THR214K, THR225H, THR225K, THR92H, THR92K, TRP89H, TRP89K, TRP94H, TRP94K, TYR12H, TYR12K, TYR219H, TYR219K, TYR238H, TYR238K, TYR51H, TYR51K, TYR93H, TYR93K, VAL222H, VAL222K, VAL232H, VAL232K, VAL99H, VAL99K
• H-L: ALA241H, ALA241L, ALA247H, ALA247L, ARG251H, ARG251L, ARG87H, ARG87L, ASN233H, ASN233L, ASN252H, ASN252L, ASN85H, ASN85L, ASP249H, ASP249L, ASP90H, ASP90L, GLU234H, GLU234L, GLU243H, GLU243L, GLU88H, GLU88L, GLY235H, GLY235L, GLY237H, GLY237L, GLY239H, GLY239L, GLY244H, GLY244L, ILE236H, ILE236L, ILE245H, ILE245L, LEU240H, LEU240L, LEU242H, LEU242L, LEU250H, LEU250L, LYS97H, LYS97L, PRO86H, PRO86L, THR246H, THR246L, THR248H, THR248L, THR84H, THR84L, TRP89H, TRP89L, TYR238H, TYR238L, TYR93H, TYR93L
• I-J: ALA241I, ALA241J, ALA247I, ALA247J, ARG251I, ARG251J, ARG87I, ARG87J, ASN233I, ASN233J, ASN252I, ASN252J, ASN85I, ASN85J, ASP249I, ASP249J, ASP82I, ASP90I, ASP90J, GLU234I, GLU234J, GLU243I, GLU243J, GLU88J, GLY235I, GLY235J, GLY237I, GLY237J, GLY239I, GLY239J, GLY244I, GLY244J, ILE236I, ILE236J, ILE245I, ILE245J, LEU240I, LEU240J, LEU242I, LEU242J, LEU250I, LEU250J, LYS97I, LYS97J, PRO86I, PRO86J, THR246I, THR246J, THR248I, THR248J, THR84I, THR84J, TRP89I, TRP89J, TYR238I, TYR238J, TYR93I, TYR93J
• I-K: ARG230I, ARG230K, GLN226I, GLN226K
• I-L: ALA223I, ALA223L, ALA241I, ALA241L, ALA49I, ARG218I, ARG218L, ARG221I, ARG221L, ARG227I, ARG227L, ARG230I, ARG230L, ARG44I, ARG44L, ARG55I, ARG55L, ARG57I, ARG57L, ARG60L, ARG87I, ARG87L, ASN102I, ASN102L, ASN216I, ASN216L, ASN233I, ASN233L, ASN85I, ASN85L, ASP105I, ASP105L, ASP48I, ASP48L, ASP52I, ASP52L, ASP56I, ASP56L, ASP90I, ASP90L, GLN101I, GLN101L, GLN212L, GLN226I, GLN226L, GLU107I, GLU107L, GLU234I, GLU234L, GLU45I, GLU45L, GLU88I, GLU88L, GLU95I, GLU95L, GLY235I, GLY235L, GLY237I, GLY237L, GLY244I, GLY244L, ILE106I, ILE106L, ILE245I, ILE245L, ILE53I, ILE53L, LEU103I, LEU103L, LEU104I, LEU104L, LEU215I, LEU215L, LEU231I, LEU231L, LEU240I, LEU240L, LYS11I, LYS11L, LYS229I, LYS229L, LYS91I, LYS91L, LYS97I, LYS97L, LYS98I, LYS98L, PHE46I, PHE50I, PHE50L, PRO213I, PRO213L, PRO47I, PRO47L, PRO86I, PRO86L, SER54I, SER54L, THR214I, THR214L, THR225I, THR225L, THR92I, THR92L, TRP89I, TRP89L, TRP94I, TRP94L, TYR12I, TYR12L, TYR219I, TYR219L, TYR238I, TYR238L, TYR51I, TYR51L, TYR93I, TYR93L, VAL222I, VAL222L, VAL99I, VAL99L
• J-K: ALA147K, ALA162J, ALA162K, ALA206J, ALA223J, ALA241K, ALA247K, ARG167K, ARG169K, ARG201J, ARG218J, ARG221J, ARG227J, ARG227K, ARG230J, ARG230K, ASN146K, ASN187J, ASN187K, ASN216J, ASN233K, ASN252K, ASP129J, ASP141K, ASP153K, ASP249K, GLN175K, GLN182K, GLN212J, GLN226J, GLU107J, GLU123J, GLU176K, GLU185J, GLU185K, GLU191J, GLU234K, GLU243K, GLY148K, GLY152K, GLY154K, GLY164J, GLY164K, GLY168K, GLY235K, GLY237K, GLY239K, GLY244K, HIS144K, HIS156K, HIS190J, ILE111J, ILE125J, ILE130J, ILE131J, ILE149K, ILE157J, ILE157K, ILE205J, ILE236K, ILE245K, LEU104J, LEU126J, LEU132J, LEU145K, LEU158J, LEU158K, LEU161J, LEU161K, LEU163J, LEU163K, LEU165J, LEU165K, LEU172K, LEU178K, LEU186J, LEU186K, LEU193J, LEU209J, LEU215J, LEU217J, LEU224J, LEU228J, LEU231J, LEU231K, LEU240K, LEU242K, LEU250K, LYS211J, LYS229J, PHE171K, PHE173K, PRO109J, PRO143K, PRO151K, PRO160J, PRO160K, PRO213J, SER112J, THR127J, THR128J, THR174K, THR208J, THR214J, THR220J, THR225J, THR246K, THR248K, TRP159J, TRP159K, TYR124J, TYR166K, TYR170K, TYR184J, TYR219J, TYR238K, VAL108J, VAL110J, VAL150K, VAL155K, VAL188J, VAL189J, VAL222J, VAL232J, VAL232K, VAL61J
• J-L: ALA147J, ALA162J, ALA162L, ALA206L, ALA223L, ALA241J, ALA247J, ARG167J, ARG169J, ARG201L, ARG218L, ARG221L, ARG227J, ARG227L, ARG230J, ARG230L, ASN146J, ASN187J, ASN187L, ASN216L, ASN233J, ASN252J, ASP129L, ASP141J, ASP153J, ASP249J, GLN175J, GLN182J, GLN212L, GLN226L, GLU107L, GLU123L, GLU176J, GLU185J, GLU185L, GLU191L, GLU234J, GLU243J, GLY148J, GLY152J, GLY154J, GLY164J, GLY164L, GLY168J, GLY235J, GLY237J, GLY239J, GLY244J, HIS144J, HIS156J, HIS190L, ILE111L, ILE125L, ILE130L, ILE131L, ILE149J, ILE157J, ILE157L, ILE205L, ILE236J, ILE245J, LEU104L, LEU126L, LEU132L, LEU145J, LEU158J, LEU158L, LEU161J, LEU161L, LEU163J, LEU163L, LEU165J, LEU165L, LEU172J, LEU186J, LEU186L, LEU193L, LEU209L, LEU215L, LEU217L, LEU224L, LEU228L, LEU231J, LEU231L, LEU240J, LEU242J, LEU250J, LYS211L, LYS229L, PHE171J, PHE173J, PRO109L, PRO143J, PRO151J, PRO160J, PRO160L, PRO213L, SER112L, THR127L, THR128L, THR174J, THR208L, THR214L, THR220L, THR225L, THR246J, THR248J, TRP159J, TRP159L, TYR124L, TYR166J, TYR170J, TYR184L, TYR219L, TYR238J, VAL108L, VAL110L, VAL150J, VAL155J, VAL188L, VAL189L, VAL222L, VAL232J, VAL232L, VAL61L
• K-L: ALA147L, ALA162K, ALA162L, ALA183K, ALA206K, ALA223K, ALA241L, ALA247L, ARG167L, ARG169L, ARG201K, ARG218K, ARG221K, ARG227K, ARG227L, ARG230K, ARG230L, ASN146L, ASN187K, ASN187L, ASN216K, ASN233L, ASN252L, ASP129K, ASP141L, ASP153L, ASP249L, GLN175L, GLN182L, GLN212K, GLN226K, GLU107K, GLU123K, GLU176L, GLU185K, GLU185L, GLU191K, GLU234L, GLU243L, GLY148L, GLY152L, GLY154L, GLY164K, GLY164L, GLY168L, GLY235L, GLY237L, GLY239L, GLY244L, HIS144L, HIS156L, HIS190K, ILE111K, ILE125K, ILE130K, ILE131K, ILE149L, ILE157K, ILE157L, ILE205K, ILE236L, ILE245L, LEU104K, LEU126K, LEU132K, LEU145L, LEU158K, LEU158L, LEU161K, LEU161L, LEU163K, LEU163L, LEU165K, LEU165L, LEU172L, LEU186K, LEU186L, LEU193K, LEU209K, LEU215K, LEU217K, LEU224K, LEU228K, LEU231K, LEU231L, LEU240L, LEU242L, LEU250L, LYS211K, LYS229K, PHE171L, PHE173L, PRO109K, PRO143L, PRO151L, PRO160K, PRO160L, PRO213K, THR127K, THR128K, THR174L, THR208K, THR214K, THR220K, THR225K, THR246L, THR248L, TRP159K, TRP159L, TYR124K, TYR166L, TYR170L, TYR184K, TYR219K, TYR238L, VAL108K, VAL110K, VAL150L, VAL155L, VAL188K, VAL189K, VAL192K, VAL222K, VAL232K, VAL232L, VAL61K