2J4L

crystal structure of uridylate kinase from sulfolobus solfataricus in complex with utp to 2.8 angstrom resolution

• Total interactions analyzed: 66
• Total true interactions: 29
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 120
  • Norm. En. per Res.: -3.5183
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-30.0853	-45.0608	-347.047	-422.1931	120	16	28	15285	3	18	12
A-C	-2.1264	8.3522	-58.8699	-52.644	34	2	0	2259	0	13	14
A-E	-41.3649	7.4846	-240.341	-274.2213	99	21	2	11180	12	21	20
A-F	0.0	7.5232	-52.6435	-45.1203	32	0	0	2170	0	11	12
A-L	0.0	-1.9815	-0.0198	-2.0013	4	0	0	14	0	3	2
B-C	-39.5563	-32.1691	-246.231	-317.9564	98	22	2	11333	13	22	19
B-D	0.0	8.3815	-58.9475	-50.566	34	4	0	2366	0	12	14
B-E	-10.5734	7.128	-61.9114	-65.3568	35	5	0	2416	0	12	13
C-D	-17.0435	-14.2404	-319.918	-351.2019	114	22	27	14143	2	14	9
C-F	-6.344	6.723	-58.6538	-58.2747	32	5	0	2285	0	12	13
D-E	0.0	-4.0789	-54.9855	-59.0644	32	3	0	2205	0	10	12
D-F	-33.8884	9.7263	-237.882	-262.0441	94	16	2	10631	12	21	21
E-F	-33.5268	-19.9894	-364.689	-418.2052	125	36	30	16514	1	21	12
E-L	0.0	7.2325	-61.9717	-54.7392	31	2	0	2617	0	14	12
F-G	0.0	0.0	-0.0639	-0.0639	5	0	0	24	0	3	2
F-K	0.0	-7.1129	-60.6978	-67.8107	28	1	0	2499	3	14	14
F-L	-48.6799	34.2862	-146.337	-160.7308	60	20	1	5825	8	30	35
G-H	-15.8657	-35.9841	-332.839	-384.6888	113	38	27	14299	2	14	12
G-I	-3.2827	8.1065	-58.3881	-53.5643	34	0	0	2284	0	12	12
G-K	-31.4627	-0.0147	-223.067	-254.5444	92	13	2	10586	13	22	22
G-L	-4.4345	8.5043	-56.2205	-52.1507	34	1	0	2189	0	11	12
H-I	-33.4092	7.6779	-213.434	-239.1653	91	13	2	10146	12	20	22
H-J	-4.3337	8.0559	-61.6074	-57.8852	34	4	0	2306	0	11	13
H-K	-11.1403	6.9119	-60.9947	-65.2232	35	3	0	2339	0	12	12
I-J	-21.6928	-18.2463	-320.675	-360.6142	117	33	25	14220	2	17	13
I-L	-13.9956	6.883	-60.3493	-67.462	36	5	0	2403	0	11	13
J-K	-3.6435	8.9757	-61.4659	-56.1337	35	4	0	2388	0	11	12
J-L	-37.5965	-1.0448	-237.497	-276.1383	90	15	2	10599	14	20	18
K-L	-13.9777	-29.3341	-340.445	-383.7568	119	35	28	14829	1	17	14

Interface residues

• A-B: ALA47A, ALA47B, ALA54A, ALA54B, ALA62A, ALA62B, ALA71A, ALA71B, ALA76A, ALA76B, ARG24A, ARG24B, ARG49A, ARG49B, ARG55A, ARG55B, ARG73A, ARG73B, ASN16A, ASN16B, ASN19A, ASN19B, ASN75A, ASN75B, ASP13A, ASP13B, ASP15A, ASP15B, ASP18A, ASP18B, ASP65A, ASP65B, ASP85A, ASP85B, GLN84A, GLN84B, GLN93A, GLN93B, GLU14A, GLU14B, GLU56A, GLU56B, GLY42A, GLY42B, GLY43A, GLY43B, GLY44A, GLY44B, GLY58A, GLY58B, GLY60A, GLY60B, GLY68A, GLY68B, GLY9A, GLY9B, HIS90A, HIS90B, ILE21A, ILE21B, ILE51A, ILE51B, ILE57A, ILE57B, ILE59A, ILE59B, ILE69A, ILE69B, LEU20A, LEU20B, LEU53A, LEU53B, LEU64A, LEU64B, LEU66A, LEU66B, LEU67A, LEU67B, LEU74A, LEU74B, LEU78A, LEU78B, LEU83A, LEU83B, LYS10A, LYS10B, LYS52A, LYS52B, MET80A, MET80B, MET89A, MET89B, PHE11A, PHE11B, PHE12A, PHE12B, PHE81A, PHE81B, SER45A, SER45B, SER72A, SER72B, SER82A, SER82B, THR46A, THR46B, TRP70A, TRP70B, TYR50A, TYR50B, TYR63A, TYR63B, TYR77A, TYR77B, VAL17A, VAL17B, VAL79A, VAL79B, VAL91A, VAL91B
• A-C: ALA129C, ALA87A, ARG36C, ASN2C, ASP101A, ASP101C, ASP85A, GLN100A, GLN100C, GLN84A, GLU128C, GLU96C, GLU97A, GLU97C, GLY105C, HIS104A, HIS104C, HIS90A, ILE99C, LYS106A, MET80A, MET89A, PHE81A, PHE98C, PRO92A, SER103A, SER103C, SER130C, SER131C, TRP102C, TYR77A, TYR88A, TYR88C, VAL91A
• A-E: ALA121A, ALA121E, ALA124A, ALA124E, ALA127A, ALA127E, ALA129A, ALA129E, ALA178E, ALA62A, ALA62E, ARG194A, ARG194E, ARG55A, ARG55E, ARG73A, ARG73E, ASP185A, ASP185E, ASP65A, ASP65E, GLN100A, GLN114A, GLN114E, GLN117A, GLN117E, GLN177E, GLN93A, GLN93E, GLU128A, GLU128E, GLU182E, GLU193A, GLU61A, GLU61E, GLU96A, GLU96E, GLU97A, GLU97E, GLY112A, GLY112E, GLY116A, GLY116E, GLY179E, GLY60A, GLY60E, ILE191A, ILE191E, ILE197A, ILE197E, ILE69A, ILE69E, ILE99A, ILE99E, LEU125A, LEU125E, LEU187A, LEU187E, LEU64A, LEU64E, LEU66A, LEU66E, LEU95A, LEU95E, LYS190A, LYS190E, LYS196A, PHE113A, PHE113E, PHE98A, PHE98E, PRO115A, PRO115E, PRO186A, PRO186E, SER103A, SER118A, SER118E, SER130A, SER130E, SER131A, SER131E, SER195A, SER195E, SER94A, SER94E, THR110A, THR180E, TRP102A, TRP102E, TRP70A, TRP70E, TYR181E, TYR63A, TYR63E, VAL122A, VAL122E, VAL126A, VAL126E
• A-F: ALA129A, ALA87F, ARG36A, ASN2A, ASP101A, ASP101F, ASP85F, GLN100A, GLN100F, GLN84F, GLU96A, GLU97A, GLU97F, GLY105A, HIS104A, HIS104F, HIS90F, ILE99A, LYS106F, MET80F, MET89F, PHE81F, PHE98A, PRO92F, SER103A, SER130A, SER131A, TRP102A, TYR77F, TYR88A, TYR88F, VAL91F
• A-L: ALA153L, ARG194A, ASP154L, LYS196A
• B-C: ALA121B, ALA121C, ALA124B, ALA124C, ALA127B, ALA127C, ALA129B, ALA129C, ALA178C, ALA62B, ALA62C, ARG194B, ARG194C, ARG55B, ARG55C, ARG73B, ARG73C, ASP185B, ASP185C, ASP65B, ASP65C, GLN100B, GLN114B, GLN114C, GLN117B, GLN117C, GLN177C, GLN93B, GLN93C, GLU128B, GLU128C, GLU182C, GLU193B, GLU61B, GLU61C, GLU96B, GLU96C, GLU97B, GLU97C, GLY112B, GLY112C, GLY116B, GLY116C, GLY179C, GLY60B, GLY60C, ILE191B, ILE191C, ILE197B, ILE197C, ILE69B, ILE69C, ILE99B, ILE99C, LEU125B, LEU125C, LEU187B, LEU187C, LEU64B, LEU64C, LEU66B, LEU66C, LEU95B, LEU95C, LYS190B, LYS190C, LYS196B, PHE113B, PHE113C, PHE98B, PHE98C, PRO115B, PRO115C, PRO186B, PRO186C, SER103B, SER118B, SER118C, SER130B, SER130C, SER131B, SER131C, SER195B, SER195C, SER94B, SER94C, THR180C, TRP102B, TRP102C, TRP70B, TRP70C, TYR181C, TYR63B, TYR63C, VAL122B, VAL122C, VAL126B, VAL126C
• B-D: ALA129B, ALA87D, ARG36B, ASN2B, ASP101B, ASP101D, ASP85D, GLN100B, GLN100D, GLN84D, GLU128B, GLU96B, GLU97B, GLU97D, GLY105B, HIS104B, HIS104D, HIS90D, ILE99B, LEU86D, LYS106D, MET80D, MET89D, PHE81D, PHE98B, PRO92D, SER103B, SER130B, SER131B, TRP102B, TYR77D, TYR88B, TYR88D, VAL91D
• B-E: ALA129E, ALA87B, ARG36E, ASN2E, ASP101B, ASP101E, ASP85B, GLN100B, GLN100E, GLN84B, GLU128E, GLU96E, GLU97B, GLU97E, GLY105E, HIS104B, HIS104E, HIS90B, ILE99E, LEU86B, LYS106B, LYS106E, MET80B, MET89B, PHE81B, PHE98E, PRO92B, SER103E, SER130E, SER131E, TRP102E, TYR77B, TYR88B, TYR88E, VAL91B
• C-D: ALA47C, ALA47D, ALA54C, ALA54D, ALA62C, ALA62D, ALA71C, ALA71D, ALA76C, ALA76D, ARG24D, ARG48D, ARG49C, ARG49D, ARG55C, ARG55D, ARG73C, ARG73D, ASN16D, ASN19D, ASN75C, ASN75D, ASP13C, ASP13D, ASP15D, ASP18D, ASP65C, ASP65D, ASP85C, ASP85D, GLN84C, GLN84D, GLN93C, GLN93D, GLU14C, GLU14D, GLU56C, GLU56D, GLU61C, GLY42C, GLY42D, GLY43C, GLY43D, GLY44C, GLY44D, GLY58C, GLY58D, GLY60C, GLY60D, GLY68C, GLY68D, GLY9D, HIS90C, HIS90D, ILE21D, ILE51C, ILE51D, ILE57C, ILE57D, ILE59C, ILE59D, ILE69C, ILE69D, LEU20D, LEU23D, LEU53C, LEU53D, LEU64C, LEU64D, LEU66C, LEU66D, LEU67C, LEU67D, LEU74C, LEU74D, LEU78C, LEU78D, LEU83C, LEU83D, LYS10D, LYS52C, LYS52D, MET80C, MET80D, MET89C, MET89D, PHE11C, PHE11D, PHE12C, PHE12D, PHE81C, PHE81D, SER45C, SER45D, SER72C, SER72D, SER82C, SER82D, THR46C, THR46D, TRP70C, TRP70D, TYR50C, TYR50D, TYR63C, TYR63D, TYR77C, TYR77D, VAL17D, VAL22D, VAL79C, VAL79D, VAL91C, VAL91D
• C-F: ALA129F, ALA87C, ARG36F, ASN2F, ASP101C, ASP101F, ASP85C, GLN100C, GLN100F, GLN84C, GLU96F, GLU97C, GLU97F, GLY105F, HIS104C, HIS104F, HIS90C, ILE99F, LYS106C, MET80C, MET89C, PHE81C, PHE98F, PRO92C, SER103F, SER130F, SER131F, TRP102F, TYR77C, TYR88C, TYR88F, VAL91C
• D-E: ALA129D, ALA87E, ARG36D, ASN2D, ASP101D, ASP101E, ASP85E, GLN100D, GLN100E, GLN84E, GLU96D, GLU97D, GLU97E, GLY105D, HIS104D, HIS104E, HIS90E, ILE99D, LYS106E, MET80E, MET89E, PHE81E, PHE98D, PRO92E, SER103D, SER130D, SER131D, TRP102D, TYR77E, TYR88D, TYR88E, VAL91E
• D-F: ALA121D, ALA121F, ALA124D, ALA124F, ALA127D, ALA127F, ALA129D, ALA129F, ALA62D, ALA62F, ARG194D, ARG194F, ARG55D, ARG55F, ARG73D, ARG73F, ASP185D, ASP185F, ASP65D, ASP65F, GLN100D, GLN100F, GLN114D, GLN114F, GLN117D, GLN117F, GLN93D, GLN93F, GLU128D, GLU128F, GLU61D, GLU61F, GLU96D, GLU96F, GLU97D, GLU97F, GLY112D, GLY112F, GLY116D, GLY116F, GLY179F, GLY60D, GLY60F, ILE191D, ILE191F, ILE197D, ILE197F, ILE69D, ILE69F, ILE99D, ILE99F, LEU125D, LEU125F, LEU187D, LEU187F, LEU64D, LEU64F, LEU66D, LEU66F, LEU95D, LEU95F, LYS190D, LYS190F, PHE113D, PHE113F, PHE98D, PHE98F, PRO115D, PRO115F, PRO186D, PRO186F, SER118D, SER118F, SER130D, SER130F, SER131D, SER131F, SER195D, SER195F, SER94D, SER94F, THR110D, THR180F, TRP102D, TRP102F, TRP70D, TRP70F, TYR181F, TYR63D, TYR63F, VAL122D, VAL122F, VAL126D, VAL126F
• E-F: ALA47E, ALA47F, ALA54E, ALA54F, ALA62E, ALA62F, ALA71E, ALA71F, ALA76E, ALA76F, ARG24E, ARG24F, ARG49E, ARG49F, ARG55E, ARG55F, ARG73E, ARG73F, ASN16E, ASN16F, ASN19E, ASN19F, ASN75E, ASN75F, ASP13E, ASP13F, ASP15E, ASP15F, ASP18E, ASP18F, ASP65E, ASP65F, ASP85E, ASP85F, GLN84E, GLN84F, GLN93E, GLN93F, GLU14E, GLU14F, GLU56E, GLU56F, GLY42E, GLY42F, GLY43E, GLY43F, GLY44E, GLY44F, GLY58E, GLY58F, GLY60E, GLY60F, GLY68E, GLY68F, GLY9E, GLY9F, HIS90E, HIS90F, ILE21E, ILE21F, ILE51E, ILE51F, ILE57E, ILE57F, ILE59E, ILE59F, ILE69E, ILE69F, LEU20E, LEU20F, LEU23E, LEU23F, LEU53E, LEU53F, LEU64E, LEU64F, LEU66E, LEU66F, LEU67E, LEU67F, LEU74E, LEU74F, LEU78E, LEU78F, LEU83E, LEU83F, LYS10E, LYS10F, LYS52E, LYS52F, MET80E, MET80F, MET89E, MET89F, PHE11E, PHE11F, PHE12E, PHE12F, PHE81E, PHE81F, SER45E, SER45F, SER72E, SER72F, SER82E, SER82F, THR41F, THR46E, THR46F, TRP70E, TRP70F, TYR50E, TYR50F, TYR63E, TYR63F, TYR77E, TYR77F, VAL17E, VAL17F, VAL22E, VAL22F, VAL79E, VAL79F, VAL91E, VAL91F
• E-L: ALA153L, ALA178E, ALA54E, ARG150L, ARG48E, ARG49E, ARG55E, ASN140L, ASP142L, ASP148L, ASP154L, GLN177E, GLU56E, GLU61E, GLY179E, GLY58E, GLY60E, ILE151L, ILE51E, ILE57E, ILE59E, LEU53E, LEU64E, LYS52E, PRO149L, THR180E, TYR145L, TYR152L, TYR50E, VAL141L, VAL155L
• F-G: ALA153F, ARG194G, ASP154F, LYS196G, SER195G
• F-K: ALA153F, ALA54K, ARG150F, ARG48K, ARG49K, ARG55K, ASN140F, ASP142F, ASP148F, ASP154F, GLU56K, GLU61K, GLY58K, GLY60K, ILE151F, ILE51K, ILE57K, ILE59K, LEU53K, LEU64K, LYS10F, LYS52K, PRO149F, TYR145F, TYR152F, TYR50K, VAL141F, VAL155F
• F-L: ARG150F, ARG150L, ARG205F, ARG205L, ARG209F, ARG48F, ASN140F, ASN140L, ASN16F, ASN16L, ASN19F, ASN19L, ASN203F, ASN203L, ASN208F, ASN208L, ASP13F, ASP13L, ASP142F, ASP142L, ASP15F, ASP15L, ASP18F, ASP18L, GLN25F, GLN25L, GLU14F, GLU14L, GLY143F, GLY143L, ILE21F, ILE21L, LEU157L, LEU20F, LYS10F, LYS10L, LYS206F, LYS206L, MET202F, MET202L, PHE11F, PHE11L, PRO149F, PRO149L, SER8F, SER8L, THR139F, THR139L, TYR145F, TYR145L, TYR204F, TYR204L, VAL141F, VAL141L, VAL17F, VAL17L, VAL219F, VAL219L, VAL22F, VAL22L
• G-H: ALA47G, ALA47H, ALA54G, ALA54H, ALA62G, ALA62H, ALA71G, ALA71H, ALA76G, ALA76H, ARG24G, ARG49G, ARG49H, ARG55G, ARG55H, ARG73G, ARG73H, ASN16G, ASN19G, ASN75G, ASN75H, ASP13G, ASP13H, ASP15G, ASP18G, ASP65G, ASP65H, ASP85G, ASP85H, GLN84G, GLN84H, GLN93G, GLN93H, GLU14G, GLU14H, GLU56G, GLU56H, GLU61H, GLY42G, GLY42H, GLY43G, GLY43H, GLY44G, GLY44H, GLY58G, GLY58H, GLY60G, GLY60H, GLY68G, GLY68H, GLY9G, HIS90G, HIS90H, ILE21G, ILE51G, ILE51H, ILE57G, ILE57H, ILE59G, ILE59H, ILE69G, ILE69H, LEU20G, LEU23G, LEU53G, LEU53H, LEU64G, LEU64H, LEU66G, LEU66H, LEU67G, LEU67H, LEU74G, LEU74H, LEU78G, LEU78H, LEU83G, LEU83H, LYS10G, LYS52G, LYS52H, MET80G, MET80H, MET89G, MET89H, PHE11G, PHE11H, PHE12G, PHE12H, PHE81G, PHE81H, SER45G, SER45H, SER72G, SER72H, SER82G, SER82H, THR46G, THR46H, TRP70G, TRP70H, TYR50G, TYR50H, TYR63G, TYR63H, TYR77G, TYR77H, VAL17G, VAL22G, VAL79G, VAL79H, VAL91G, VAL91H
• G-I: ALA129I, ALA87G, ARG36I, ASN2I, ASP101G, ASP101I, ASP85G, GLN100G, GLN100I, GLN84G, GLU128I, GLU96I, GLU97G, GLU97I, GLY105I, HIS104G, HIS104I, HIS90G, ILE99I, LYS106G, MET80G, MET89G, PHE81G, PHE98I, PRO92G, SER103G, SER103I, SER130I, SER131I, TRP102I, TYR77G, TYR88G, TYR88I, VAL91G
• G-K: ALA121G, ALA121K, ALA124G, ALA124K, ALA127G, ALA127K, ALA129G, ALA129K, ALA62G, ALA62K, ARG194G, ARG194K, ARG55G, ARG55K, ARG73G, ARG73K, ASP185G, ASP185K, ASP65G, ASP65K, GLN100G, GLN100K, GLN114G, GLN114K, GLN117G, GLN117K, GLN93G, GLN93K, GLU128G, GLU128K, GLU182G, GLU61G, GLU61K, GLU96G, GLU96K, GLU97G, GLU97K, GLY112G, GLY112K, GLY116G, GLY116K, GLY60G, GLY60K, ILE191G, ILE191K, ILE197G, ILE197K, ILE69G, ILE69K, ILE99G, ILE99K, LEU125G, LEU125K, LEU187G, LEU187K, LEU64G, LEU64K, LEU66G, LEU66K, LEU95G, LEU95K, LYS190G, LYS190K, PHE113G, PHE113K, PHE98G, PHE98K, PRO115G, PRO115K, PRO186G, PRO186K, SER103K, SER118G, SER118K, SER130G, SER130K, SER131G, SER131K, SER195G, SER195K, SER94G, SER94K, TRP102G, TRP102K, TRP70G, TRP70K, TYR63G, TYR63K, VAL122G, VAL122K, VAL126G, VAL126K
• G-L: ALA129G, ALA87L, ARG36G, ASN2G, ASP101G, ASP101L, ASP85L, GLN100G, GLN100L, GLN84L, GLU128G, GLU96G, GLU97G, GLU97L, GLY105G, HIS104G, HIS104L, HIS90L, ILE99G, LYS106L, MET80L, MET89L, PHE81L, PHE98G, PRO92L, SER103G, SER103L, SER130G, SER131G, TRP102G, TYR77L, TYR88G, TYR88L, VAL91L
• H-I: ALA121H, ALA121I, ALA124H, ALA124I, ALA127H, ALA127I, ALA129H, ALA129I, ALA62H, ALA62I, ARG194H, ARG194I, ARG55H, ARG55I, ARG73H, ARG73I, ASP185H, ASP185I, ASP65H, ASP65I, GLN100H, GLN100I, GLN114H, GLN114I, GLN117H, GLN117I, GLN93H, GLN93I, GLU128H, GLU128I, GLU61H, GLU61I, GLU96H, GLU96I, GLU97H, GLU97I, GLY112H, GLY112I, GLY116H, GLY116I, GLY60H, GLY60I, ILE191H, ILE191I, ILE197H, ILE197I, ILE69H, ILE69I, ILE99H, ILE99I, LEU125H, LEU125I, LEU187H, LEU187I, LEU64H, LEU64I, LEU66H, LEU66I, LEU95H, LEU95I, LYS190H, LYS190I, PHE113H, PHE113I, PHE98H, PHE98I, PRO115H, PRO115I, PRO186H, PRO186I, SER103I, SER118H, SER118I, SER130H, SER130I, SER131H, SER131I, SER195H, SER195I, SER94H, SER94I, TRP102H, TRP102I, TRP70H, TRP70I, TYR63H, TYR63I, VAL122H, VAL122I, VAL126H, VAL126I
• H-J: ALA129H, ALA87J, ASP101H, ASP101J, ASP85J, GLN100H, GLN100J, GLN84J, GLU128H, GLU96H, GLU97H, GLU97J, GLY105H, GLY105J, HIS104H, HIS104J, HIS90J, ILE99H, LYS106H, LYS106J, MET80J, MET89J, PHE81J, PHE98H, PRO92J, SER103H, SER103J, SER130H, SER131H, TRP102H, TYR77J, TYR88H, TYR88J, VAL91J
• H-K: ALA129K, ALA87H, ARG36K, ASN2K, ASP101H, ASP101K, ASP85H, GLN100H, GLN100K, GLN84H, GLU128K, GLU96K, GLU97H, GLU97K, GLY105K, HIS104H, HIS104K, HIS90H, ILE99K, LYS106H, LYS106K, MET80H, MET89H, PHE81H, PHE98K, PRO92H, SER103H, SER103K, SER130K, SER131K, TRP102K, TYR77H, TYR88H, TYR88K, VAL91H
• I-J: ALA47I, ALA47J, ALA54I, ALA54J, ALA62I, ALA62J, ALA71I, ALA71J, ALA76I, ALA76J, ARG24J, ARG48J, ARG49I, ARG49J, ARG55I, ARG55J, ARG73I, ARG73J, ASN16J, ASN19J, ASN75I, ASN75J, ASP13I, ASP13J, ASP15I, ASP15J, ASP18J, ASP65I, ASP65J, ASP85I, ASP85J, GLN84I, GLN84J, GLN93I, GLN93J, GLU14I, GLU14J, GLU56I, GLU56J, GLU61I, GLY42I, GLY42J, GLY43I, GLY43J, GLY44I, GLY44J, GLY58I, GLY58J, GLY60I, GLY60J, GLY68I, GLY68J, GLY9I, GLY9J, HIS90I, HIS90J, ILE21J, ILE51I, ILE51J, ILE57I, ILE57J, ILE59I, ILE59J, ILE69I, ILE69J, LEU20J, LEU23J, LEU53I, LEU53J, LEU64I, LEU64J, LEU66I, LEU66J, LEU67I, LEU67J, LEU74I, LEU74J, LEU78I, LEU78J, LEU83I, LEU83J, LYS10I, LYS10J, LYS52I, LYS52J, MET80I, MET80J, MET89I, MET89J, PHE11I, PHE11J, PHE12I, PHE12J, PHE81I, PHE81J, SER45I, SER45J, SER72I, SER72J, SER82I, SER82J, THR46I, THR46J, TRP70I, TRP70J, TYR50I, TYR50J, TYR63I, TYR63J, TYR77I, TYR77J, VAL17J, VAL22J, VAL79I, VAL79J, VAL91I, VAL91J
• I-L: ALA129L, ALA87I, ARG36L, ASN2L, ASP101I, ASP101L, ASP85I, GLN100I, GLN100L, GLN84I, GLU128L, GLU96L, GLU97I, GLU97L, GLY105L, HIS104I, HIS104L, HIS90I, ILE99L, LEU86I, LYS106I, LYS106L, MET80I, MET89I, PHE81I, PHE98L, PRO92I, SER103I, SER103L, SER130L, SER131L, TRP102L, TYR77I, TYR88I, TYR88L, VAL91I
• J-K: ALA129J, ALA87K, ARG36J, ASN2J, ASP101J, ASP101K, ASP85K, GLN100J, GLN100K, GLN84K, GLU128J, GLU96J, GLU97J, GLU97K, GLY105J, HIS104J, HIS104K, HIS90K, ILE99J, LEU86K, LYS106K, MET80K, MET89K, PHE81K, PHE98J, PRO92K, SER103J, SER103K, SER130J, SER131J, TRP102J, TYR77K, TYR88J, TYR88K, VAL91K
• J-L: ALA121J, ALA121L, ALA124J, ALA124L, ALA127J, ALA127L, ALA129J, ALA129L, ALA62J, ALA62L, ARG194J, ARG194L, ARG55J, ARG55L, ARG73J, ARG73L, ASP185J, ASP185L, ASP65J, ASP65L, GLN100J, GLN100L, GLN114J, GLN114L, GLN117J, GLN117L, GLN93J, GLN93L, GLU128J, GLU128L, GLU61J, GLU61L, GLU96J, GLU96L, GLU97J, GLU97L, GLY112J, GLY112L, GLY116J, GLY116L, GLY60J, GLY60L, ILE191J, ILE191L, ILE197J, ILE197L, ILE69J, ILE69L, ILE99J, ILE99L, LEU125J, LEU125L, LEU187J, LEU187L, LEU64J, LEU64L, LEU66J, LEU66L, LEU95J, LEU95L, LYS190J, LYS190L, PHE113J, PHE113L, PHE98J, PHE98L, PRO115J, PRO115L, PRO186J, PRO186L, SER118J, SER118L, SER130J, SER130L, SER131J, SER131L, SER195J, SER195L, SER94J, SER94L, TRP102J, TRP102L, TRP70J, TRP70L, TYR63J, TYR63L, VAL122J, VAL122L, VAL126J, VAL126L
• K-L: ALA47K, ALA47L, ALA54K, ALA54L, ALA62K, ALA62L, ALA71K, ALA71L, ALA76K, ALA76L, ARG24L, ARG48K, ARG49K, ARG49L, ARG55K, ARG55L, ARG73K, ARG73L, ASN16K, ASN16L, ASN19L, ASN75K, ASN75L, ASP13K, ASP13L, ASP15K, ASP15L, ASP18K, ASP18L, ASP65K, ASP65L, ASP85K, ASP85L, GLN84K, GLN84L, GLN93K, GLN93L, GLU14K, GLU14L, GLU56K, GLU56L, GLY42K, GLY42L, GLY43K, GLY43L, GLY44K, GLY44L, GLY58K, GLY58L, GLY60K, GLY60L, GLY68K, GLY68L, GLY9K, GLY9L, HIS90K, HIS90L, ILE21L, ILE51K, ILE51L, ILE57K, ILE57L, ILE59K, ILE59L, ILE69K, ILE69L, LEU20L, LEU23L, LEU53K, LEU53L, LEU64K, LEU64L, LEU66K, LEU66L, LEU67K, LEU67L, LEU74K, LEU74L, LEU78K, LEU78L, LEU83K, LEU83L, LYS10K, LYS10L, LYS52K, LYS52L, MET80K, MET80L, MET89K, MET89L, PHE11K, PHE11L, PHE12K, PHE12L, PHE81K, PHE81L, SER45K, SER45L, SER72K, SER72L, SER82K, SER82L, THR46K, THR46L, TRP70K, TRP70L, TYR50K, TYR50L, TYR63K, TYR63L, TYR77K, TYR77L, VAL17K, VAL17L, VAL22L, VAL79K, VAL79L, VAL91K, VAL91L