2J0Q

the crystal structure of the exon junction complex at 3.2 a resolution

• Total interactions analyzed: 45
• Total true interactions: 13
• Strongest Interaction:
  • Chains: A-T
  • Int. Res.: 170
  • Norm. En. per Res.: -4.6149
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	16.9837	-1.2754	15.7083	13	0	0	104	0	14	8
A-C	-94.1549	-97.2548	-438.622	-630.0317	151	18	5	16158	12	63	59
A-D	-9.6818	-57.9528	-18.2984	-85.933	38	5	0	839	4	16	10
A-G	-5.908	-15.0015	-90.2764	-111.1859	43	2	2	3689	0	16	15
A-T	-86.9394	-113.8509	-583.739	-784.5293	170	24	3	20197	11	106	113
B-D	-10.5	-7.6864	-94.1715	-112.3579	44	3	2	3712	0	16	15
B-F	-96.6136	-100.5628	-444.226	-641.4023	152	22	5	16220	11	63	59
B-G	-9.0469	-55.1152	-20.2563	-84.4184	37	3	0	828	4	15	10
B-I	-97.2723	-66.5352	-546.544	-710.3515	164	16	3	18957	9	97	103
C-D	-44.4679	-23.8851	-321.318	-389.671	98	8	9	12081	2	31	32
C-T	0.0	20.8187	-88.2279	-67.4093	28	3	0	3178	2	13	18
F-G	-38.4355	-25.126	-324.438	-387.9996	97	10	9	12192	2	31	32
F-I	-15.7164	14.4523	-90.2834	-91.5475	27	2	0	3173	2	14	17

Interface residues

• A-B: ASP35A, ASP35B, GLU32B, GLU33A, GLU33B, LYS70A, LYS70B, PRO38A, PRO38B, THR42A, THR42B, VAL36A, VAL36B
• A-C: ALA257A, ALA35C, ALA63A, ARG243A, ARG339A, ARG358A, ARG370A, ARG373A, ARG387A, ARG390A, ARG47C, ARG67A, ARG82C, ARG85C, ASN194A, ASN356A, ASN357A, ASN36C, ASN37C, ASN383A, ASN39C, ASN42C, ASP109C, ASP128C, ASP190A, ASP22A, ASP244A, ASP384A, ASP391A, ASP401A, ASP43C, ASP81C, CYS131C, GLN112C, GLN127C, GLN394A, GLN399A, GLN65A, GLN66A, GLN83A, GLN86C, GLU191A, GLU20C, GLU224A, GLU227A, GLU23C, GLU245A, GLU249A, GLU259A, GLU27A, GLU359A, GLU393A, GLU402A, GLY105C, GLY12C, GLY138C, GLY15C, GLY250A, GLY369A, GLY372A, GLY84C, GLY85A, GLY87A, HIS13C, HIS140C, HIS19C, HIS223A, ILE104C, ILE108C, ILE137C, ILE143C, ILE146C, ILE225A, ILE386A, ILE388A, ILE392A, ILE400A, ILE46C, ILE64A, LEU107C, LEU125C, LEU129C, LEU132C, LEU139C, LEU221A, LEU226A, LEU22C, LEU240A, LEU246A, LEU248A, LEU360A, LEU389A, LYS103C, LYS130C, LYS142C, LYS144C, LYS16C, LYS242A, LYS25A, LYS382A, LYS41C, LYS48C, LYS60A, MET23A, MET403A, MET45C, PHE134C, PHE141C, PHE17C, PHE21C, PHE24C, PHE255A, PHE28A, PRO145C, PRO222A, PRO61A, SER106C, SER135C, SER38C, SER397A, SER62A, SER82A, SER84A, THR220A, THR247A, THR24A, THR30A, THR398A, THR86A, TRP263A, TYR10C, TYR123C, TYR124C, TYR34C, TYR371A, TYR395A, TYR396A, TYR40C, TYR9C, VAL110C, VAL11C, VAL126C, VAL133C, VAL241A, VAL256A, VAL258A, VAL26A, VAL36A, VAL381A, VAL44C, VAL83C
• A-D: ALA63A, ARG108D, ARG109D, ARG390A, ARG67A, ASN101D, ASN105D, ASN406A, ASP401A, GLN253A, GLN399A, GLN66A, GLU245A, GLU249A, GLU393A, GLU402A, GLU71D, GLU86D, GLU98D, GLY111D, HIS103D, ILE102D, ILE400A, LEU104D, LEU106D, LEU410A, LYS100D, LYS252A, LYS374A, LYS60A, MET405A, PHE254A, PHE255A, PRO404A, THR110D, THR398A, VAL36A, VAL70D
• A-G: ALA55A, ARG152G, ARG46A, ARG51A, ARG68G, ASP41A, ASP48A, GLN128G, GLN67G, GLU122G, GLU126G, GLU132G, GLU47A, GLU59A, GLU71G, GLY44A, GLY52A, GLY57A, GLY72G, ILE53A, LEU45A, LEU50A, LYS125G, LYS60A, MET131G, MET43A, PHE40A, PHE58A, PRO38A, PRO61A, PRO66G, SER69G, THR123G, THR39A, THR42A, TRP148G, TRP73G, TYR124G, TYR132A, TYR54A, TYR56A, VAL151G, VAL70G
• A-T: ALA180A, ALA180T, ALA211A, ALA229T, ALA247T, ARG105A, ARG151A, ARG172A, ARG174A, ARG176T, ARG177A, ARG179A, ARG184T, ARG194T, ARG206A, ARG217T, ARG224T, ARG245T, ARG260A, ARG288A, ARG358A, ARG364A, ARG387A, ARG390A, ASN134A, ASN178T, ASN194A, ASN230A, ASN285A, ASN356A, ASN357A, ASN383A, ASP149A, ASP154A, ASP171T, ASP172T, ASP173T, ASP175T, ASP192T, ASP203A, ASP214T, ASP221T, ASP226T, ASP235A, ASP243T, ASP291A, ASP353A, ASP384A, ASP385A, ASP391A, ASP77A, CYS284A, GLN136A, GLN157A, GLN196T, GLN200A, GLN213A, GLN228T, GLN394A, GLU106A, GLU148A, GLU174T, GLU190T, GLU199A, GLU215T, GLU219T, GLU224A, GLU225T, GLU227T, GLU235T, GLU259A, GLU261A, GLU262A, GLU295A, GLU359A, GLY147A, GLY156A, GLY186T, GLY195T, GLY216T, HIS169T, HIS191T, HIS220T, HIS248T, ILE150A, ILE171A, ILE181A, ILE182T, ILE201A, ILE244T, ILE386A, ILE388A, ILE392A, LEU153A, LEU170T, LEU176A, LEU184A, LEU186A, LEU187T, LEU193A, LEU193T, LEU208A, LEU216A, LEU236T, LEU239T, LEU293A, LEU354A, LEU360A, LEU389A, LYS152A, LYS177T, LYS185T, LYS195A, LYS198A, LYS222T, LYS231A, LYS231T, LYS264A, LYS287A, LYS289A, LYS296A, LYS382A, MET192A, MET228A, MET233A, PHE168A, PHE188T, PHE189T, PHE197A, PHE223T, PHE232A, PHE265A, PHE380A, PRO179T, PRO183T, PRO209A, PRO210A, PRO222A, PRO230T, PRO236A, PRO355A, SER175A, SER232T, SER246T, THR107A, THR178A, THR197T, THR212A, THR229A, THR234A, THR286A, TRP218T, TRP263A, TRP292A, TYR155A, TYR181T, TYR202A, TYR205A, TYR207A, TYR240T, TYR242T, TYR352A, TYR361A, TYR396A, VAL104A, VAL204A, VAL214A, VAL258A, VAL290A, VAL381A
• B-D: ALA55B, ARG152D, ARG46B, ARG51B, ARG68D, ASP41B, ASP48B, GLN128D, GLN67D, GLU122D, GLU126D, GLU132D, GLU47B, GLU59B, GLU71D, GLY44B, GLY52B, GLY57B, GLY72D, ILE53B, LEU45B, LEU49B, LEU50B, LYS125D, LYS60B, MET131D, MET43B, PHE40B, PHE58B, PRO38B, PRO61B, PRO66D, SER69D, THR123D, THR39B, THR42B, TRP148D, TRP73D, TYR124D, TYR132B, TYR54B, TYR56B, VAL151D, VAL70D
• B-F: ALA257B, ALA35F, ALA63B, ARG243B, ARG339B, ARG358B, ARG370B, ARG373B, ARG387B, ARG390B, ARG47F, ARG67B, ARG82F, ARG85F, ASN194B, ASN356B, ASN357B, ASN36F, ASN37F, ASN383B, ASN39F, ASN42F, ASP109F, ASP128F, ASP190B, ASP22B, ASP244B, ASP384B, ASP391B, ASP401B, ASP43F, ASP81F, CYS131F, GLN112F, GLN127F, GLN394B, GLN399B, GLN65B, GLN66B, GLN83B, GLN86F, GLU191B, GLU20F, GLU224B, GLU227B, GLU23F, GLU245B, GLU249B, GLU259B, GLU27B, GLU359B, GLU393B, GLU402B, GLY105F, GLY12F, GLY138F, GLY15F, GLY250B, GLY369B, GLY372B, GLY84F, GLY85B, GLY87B, HIS13F, HIS140F, HIS19F, HIS223B, ILE104F, ILE108F, ILE137F, ILE143F, ILE146F, ILE225B, ILE386B, ILE388B, ILE392B, ILE400B, ILE46F, ILE64B, LEU107F, LEU125F, LEU129F, LEU132F, LEU139F, LEU221B, LEU226B, LEU22F, LEU240B, LEU246B, LEU248B, LEU360B, LEU389B, LYS103F, LYS130F, LYS142F, LYS144F, LYS16F, LYS242B, LYS25B, LYS382B, LYS41F, LYS48F, LYS60B, MET23B, MET403B, MET45F, PHE134F, PHE141F, PHE17F, PHE21F, PHE24F, PHE255B, PHE28B, PRO145F, PRO222B, PRO61B, SER106F, SER135F, SER38F, SER397B, SER62B, SER82B, SER84B, THR220B, THR247B, THR24B, THR30B, THR398B, THR86B, TRP263B, TYR10F, TYR123F, TYR124F, TYR34F, TYR361B, TYR371B, TYR395B, TYR396B, TYR40F, TYR9F, VAL110F, VAL11F, VAL126F, VAL133F, VAL241B, VAL256B, VAL258B, VAL26B, VAL36B, VAL381B, VAL44F, VAL83F
• B-G: ALA63B, ARG108G, ARG109G, ARG390B, ARG67B, ASN101G, ASN105G, ASN406B, ASP401B, GLN253B, GLN399B, GLN66B, GLU245B, GLU249B, GLU393B, GLU402B, GLU71G, GLU86G, GLU98G, GLY111G, HIS103G, ILE102G, ILE400B, LEU104G, LEU106G, LEU410B, LYS100G, LYS252B, LYS374B, LYS60B, MET405B, PHE254B, PRO404B, THR110G, THR398B, VAL36B, VAL70G
• B-I: ALA180B, ALA180I, ALA211B, ALA229I, ALA247I, ARG105B, ARG151B, ARG172B, ARG174B, ARG176I, ARG177B, ARG179B, ARG184I, ARG194I, ARG206B, ARG217I, ARG224I, ARG245I, ARG260B, ARG288B, ARG358B, ARG387B, ARG390B, ASN134B, ASN178I, ASN194B, ASN230B, ASN285B, ASN356B, ASN357B, ASN383B, ASP154B, ASP171I, ASP172I, ASP173I, ASP175I, ASP192I, ASP203B, ASP221I, ASP226I, ASP235B, ASP243I, ASP291B, ASP353B, ASP384B, ASP385B, ASP391B, CYS284B, GLN136B, GLN157B, GLN196I, GLN200B, GLN213B, GLN228I, GLN394B, GLU106B, GLU148B, GLU174I, GLU190I, GLU199B, GLU215I, GLU219I, GLU224B, GLU225I, GLU227I, GLU235I, GLU259B, GLU261B, GLU262B, GLU295B, GLU359B, GLY147B, GLY156B, GLY186I, GLY195I, GLY216I, HIS169I, HIS191I, HIS220I, HIS248I, ILE150B, ILE171B, ILE181B, ILE182I, ILE201B, ILE244I, ILE386B, ILE388B, ILE392B, LEU112B, LEU153B, LEU170I, LEU176B, LEU184B, LEU186B, LEU187I, LEU193B, LEU193I, LEU208B, LEU216B, LEU236I, LEU239I, LEU293B, LEU354B, LEU360B, LEU389B, LYS152B, LYS177I, LYS195B, LYS198B, LYS222I, LYS231B, LYS231I, LYS264B, LYS287B, LYS289B, LYS296B, LYS382B, MET192B, MET228B, MET233B, PHE168B, PHE188I, PHE189I, PHE197B, PHE223I, PHE232B, PHE265B, PHE380B, PRO179I, PRO183I, PRO209B, PRO210B, PRO222B, PRO230I, PRO355B, SER175B, SER232I, SER246I, THR107B, THR178B, THR212B, THR229B, THR234B, THR286B, TRP218I, TRP263B, TRP292B, TYR155B, TYR181I, TYR202B, TYR205B, TYR207B, TYR240I, TYR242I, TYR352B, TYR361B, TYR396B, VAL104B, VAL204B, VAL214B, VAL258B, VAL290B, VAL381B
• C-D: ALA50C, ARG108D, ARG109D, ARG120C, ARG152D, ARG27C, ARG62C, ARG68D, ASN101D, ASN105D, ASN135D, ASP107D, ASP128C, ASP147D, ASP29C, ASP66C, CYS131C, CYS149D, GLN127C, GLN67D, GLU120D, GLU49C, GLU58C, GLU59C, GLU71D, GLY115D, GLY138C, GLY153D, GLY30C, GLY72D, GLY79D, HIS103D, HIS140C, HIS53C, ILE102D, ILE137C, ILE143C, ILE146C, ILE63C, ILE64C, ILE74D, ILE99D, LEU104D, LEU106D, LEU107C, LEU113D, LEU118D, LEU125C, LEU129C, LEU132C, LEU136C, LEU139C, LEU32C, LEU60C, LEU75D, LYS100D, LYS114D, LYS130C, LYS142C, LYS144C, LYS31C, LYS48C, LYS54C, MET131D, MET57C, PHE134C, PHE141C, PHE150D, PHE26C, PHE76D, PRO145C, PRO154D, PRO66D, SER135C, SER145D, SER55C, SER67C, SER69D, THR110D, THR117D, THR78D, TRP148D, TRP73D, TYR116D, TYR123C, TYR124C, TYR51C, VAL119D, VAL121C, VAL126C, VAL133C, VAL146D, VAL151D, VAL52C, VAL56C, VAL70D, VAL77D, VAL80D
• C-T: ARG194T, ARG82C, ARG85C, ASP192T, ASP81C, GLN196T, GLU190T, GLU20C, GLY12C, GLY15C, GLY186T, GLY18C, GLY195T, GLY84C, HIS13C, HIS191T, LEU187T, LEU193T, LYS103C, LYS14C, LYS16C, LYS41C, PHE17C, PHE188T, PHE189T, TYR40C, VAL11C, VAL83C
• F-G: ALA50F, ARG108G, ARG109G, ARG120F, ARG152G, ARG27F, ARG62F, ARG68G, ASN101G, ASN105G, ASN135G, ASP107G, ASP128F, ASP147G, ASP29F, ASP66F, CYS131F, CYS149G, GLN127F, GLN67G, GLU120G, GLU49F, GLU58F, GLU59F, GLU71G, GLY115G, GLY138F, GLY153G, GLY30F, GLY72G, GLY79G, HIS103G, HIS140F, HIS53F, ILE102G, ILE137F, ILE143F, ILE146F, ILE63F, ILE64F, ILE74G, ILE99G, LEU104G, LEU106G, LEU107F, LEU113G, LEU118G, LEU125F, LEU129F, LEU132F, LEU136F, LEU139F, LEU32F, LEU60F, LEU75G, LYS100G, LYS114G, LYS130F, LYS142F, LYS144F, LYS31F, LYS54F, MET131G, MET57F, PHE134F, PHE141F, PHE150G, PHE26F, PHE76G, PRO145F, PRO154G, PRO66G, SER135F, SER145G, SER55F, SER67F, SER69G, THR110G, THR117G, THR78G, TRP148G, TRP73G, TYR116G, TYR123F, TYR124F, TYR51F, VAL119G, VAL121F, VAL126F, VAL133F, VAL146G, VAL151G, VAL52F, VAL56F, VAL70G, VAL77G, VAL80G
• F-I: ARG194I, ARG82F, ARG85F, ASP192I, ASP81F, GLN196I, GLU190I, GLU20F, GLY12F, GLY15F, GLY18F, GLY195I, GLY84F, HIS13F, HIS191I, LEU187I, LEU193I, LYS103F, LYS14F, LYS16F, LYS41F, PHE17F, PHE188I, PHE189I, TYR40F, VAL11F, VAL83F