2IUB

crystal structure of a divalent metal ion transporter cora at 2.9 a resolution.

• Total interactions analyzed: 45
• Total true interactions: 22
• Strongest Interaction:
  • Chains: C-E
  • Int. Res.: 215
  • Norm. En. per Res.: -3.2681
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-48.9103	-107.7778	-420.705	-577.3931	210	35	13	20531	12	94	69
A-C	0.0	0.0	-0.3576	-0.3576	20	0	0	134	0	0	3
A-D	-72.8137	-118.5682	-475.957	-667.3389	217	35	15	21539	13	97	68
A-E	0.0	0.0	-0.4392	-0.4392	18	0	0	155	0	0	2
B-C	-55.2055	-108.4586	-435.364	-599.0281	209	28	13	20589	10	95	67
B-D	0.0	0.0	-0.3418	-0.3418	18	0	0	131	0	0	2
B-E	0.0	0.0	-0.416	-0.416	20	0	0	145	0	0	3
C-D	0.0	0.0	-0.4416	-0.4416	18	0	0	143	0	0	2
C-E	-76.7023	-123.7194	-502.211	-702.6326	215	36	15	21900	12	99	69
D-E	-59.2293	-116.1507	-442.581	-617.961	215	34	14	20713	12	100	68
D-I	0.0	15.9373	-47.6137	-31.6764	41	4	0	2706	0	51	59
E-J	-16.2426	-0.9185	-26.6118	-43.7729	19	5	0	1084	0	19	20
F-G	-39.5657	-114.3632	-472.338	-626.2668	229	28	13	21747	10	100	68
F-H	0.0	0.0	-0.3503	-0.3503	20	0	0	129	0	0	1
F-I	-75.9145	-115.7588	-530.924	-722.5972	235	43	16	23392	11	102	66
F-J	0.0	0.0	-0.4552	-0.4552	20	0	0	154	0	0	2
G-H	-58.8428	-118.3689	-447.026	-624.2377	226	42	17	22063	10	93	68
G-I	0.0	0.0	-0.353	-0.353	18	0	0	126	0	0	2
G-J	0.0	0.0	-0.3362	-0.3362	22	0	0	132	0	0	3
H-I	0.0	0.0	-0.2897	-0.2897	19	0	0	118	0	0	3
H-J	-49.2112	-102.7818	-459.861	-611.854	217	40	14	21819	10	98	67
I-J	-55.4367	-111.2764	-494.563	-661.2761	227	40	14	22436	11	94	65

Interface residues

• A-B: ALA176A, ALA262A, ALA298A, ALA298B, ALA308A, ALA308B, ALA338B, ALA8B, ARG153A, ARG158A, ARG202A, ARG210B, ARG216B, ARG222B, ARG229A, ARG252A, ARG269A, ARG269B, ARG5B, ARG96B, ASN217B, ASN285A, ASN285B, ASN288A, ASN288B, ASN92B, ASP148A, ASP175A, ASP179A, ASP180A, ASP189A, ASP190A, ASP193A, ASP253A, ASP256A, ASP263A, ASP270A, ASP277A, ASP277B, ASP89B, GLN209B, GLN213B, GLN260A, GLN95B, GLU100B, GLU103B, GLU152A, GLU186A, GLU196A, GLU197A, GLU201A, GLU204B, GLU206B, GLU220B, GLU246A, GLU266A, GLU289A, GLU289B, GLU88B, GLY11B, GLY159A, GLY15B, GLY274A, GLY309A, GLY309B, GLY312A, GLY312B, GLY335B, HIS212B, HIS257A, HIS83B, HIS94B, ILE160A, ILE161A, ILE192A, ILE259A, ILE261A, ILE271A, ILE296A, ILE296B, ILE297A, ILE297B, ILE300A, ILE300B, ILE307A, ILE307B, ILE310A, ILE310B, ILE337A, ILE337B, LEU12B, LEU184A, LEU185A, LEU200A, LEU218B, LEU275A, LEU276A, LEU276B, LEU280A, LEU280B, LEU294A, LEU294B, LEU304A, LEU304B, LEU331B, LEU6B, LEU85B, LYS10B, LYS111B, LYS164A, LYS205B, LYS215B, LYS223B, LYS245A, LYS286A, LYS286B, LYS292A, LYS292B, LYS348A, LYS349A, LYS98B, LYS9B, MET291A, MET291B, MET302A, MET302B, MET334B, MET341A, PHE101B, PHE102B, PHE107B, PHE147A, PHE182A, PHE251A, PHE268A, PHE301A, PHE301B, PHE306A, PHE306B, PHE345A, PRO13B, PRO149A, PRO14B, PRO203A, PRO203B, PRO227B, PRO249A, PRO303A, PRO303B, PRO84B, PRO97B, SER172A, SER234B, SER273A, SER273B, SER281A, SER281B, SER282A, SER282B, SER284A, SER284B, SER7B, THR16B, THR211B, THR224B, THR247A, THR258A, THR264A, THR267A, THR287A, THR287B, THR295A, THR295B, THR299A, THR299B, THR305A, THR305B, TRP226B, TYR168A, TYR171A, TYR236A, TYR250A, TYR255A, TYR279A, TYR279B, TYR311A, TYR311B, TYR327B, TYR344A, VAL146A, VAL150A, VAL183A, VAL199A, VAL208B, VAL219B, VAL248A, VAL254A, VAL265A, VAL272A, VAL278A, VAL283A, VAL283B, VAL290A, VAL290B, VAL293A, VAL293B, VAL330B, VAL86B, VAL93B, VAL99B
• A-C: ALA298A, ALA298C, ILE297C, LEU280A, LEU280C, LEU294A, LEU294C, LYS205C, LYS348A, MET291A, MET291C, MET302A, PHE301C, SER284A, THR287A, THR287C, THR295A, THR305A, THR305C, VAL290C
• A-D: ALA176D, ALA262D, ALA298A, ALA298D, ALA308A, ALA308D, ALA338A, ALA8A, ARG153D, ARG158D, ARG202D, ARG210A, ARG216A, ARG222A, ARG229D, ARG252D, ARG269A, ARG269D, ARG5A, ARG96A, ASN217A, ASN285A, ASN285D, ASN288A, ASN288D, ASN92A, ASP148D, ASP175D, ASP179D, ASP180D, ASP189D, ASP190D, ASP193D, ASP253D, ASP256D, ASP263D, ASP270D, ASP277A, ASP277D, ASP89A, GLN209A, GLN213A, GLN260D, GLN95A, GLU100A, GLU103A, GLU152D, GLU186D, GLU196D, GLU197D, GLU201D, GLU204A, GLU206A, GLU220A, GLU246D, GLU266D, GLU289A, GLU289D, GLU88A, GLY11A, GLY159D, GLY15A, GLY274D, GLY309A, GLY309D, GLY312A, GLY312D, GLY335A, HIS212A, HIS257D, HIS83A, HIS94A, ILE160D, ILE161D, ILE192D, ILE259D, ILE261D, ILE271D, ILE296A, ILE296D, ILE297A, ILE297D, ILE300A, ILE300D, ILE307A, ILE307D, ILE310A, ILE310D, ILE337A, ILE337D, LEU12A, LEU184D, LEU185D, LEU195D, LEU200D, LEU218A, LEU221A, LEU275A, LEU275D, LEU276A, LEU276D, LEU280A, LEU280D, LEU294A, LEU294D, LEU304A, LEU304D, LEU331A, LEU6A, LEU85A, LYS10A, LYS111A, LYS164D, LYS187D, LYS205A, LYS215A, LYS223A, LYS245D, LYS286A, LYS286D, LYS292A, LYS292D, LYS348D, LYS349D, LYS98A, LYS9A, MET291A, MET291D, MET302A, MET302D, MET334A, MET341D, PHE101A, PHE102A, PHE107A, PHE147D, PHE182D, PHE251D, PHE268D, PHE301A, PHE301D, PHE306A, PHE306D, PHE345D, PRO13A, PRO149D, PRO14A, PRO203A, PRO203D, PRO227A, PRO249D, PRO303A, PRO303D, PRO84A, PRO97A, SER172D, SER273A, SER273D, SER281A, SER281D, SER282A, SER282D, SER284A, SER284D, SER7A, THR16A, THR207A, THR211A, THR224A, THR247D, THR258D, THR264D, THR267D, THR287A, THR287D, THR295A, THR295D, THR299A, THR299D, THR305A, THR305D, TRP226A, TYR168D, TYR171D, TYR181D, TYR236D, TYR250D, TYR255D, TYR279A, TYR279D, TYR311A, TYR311D, TYR327A, TYR344D, VAL146D, VAL150D, VAL183D, VAL199A, VAL199D, VAL208A, VAL219A, VAL248D, VAL254D, VAL265D, VAL272D, VAL278A, VAL278D, VAL283A, VAL283D, VAL290A, VAL290D, VAL293A, VAL293D, VAL330A, VAL86A, VAL93A, VAL99A
• A-E: ALA298A, ALA298E, ILE297A, LEU280A, LEU280E, LEU294A, LEU294E, MET291A, MET291E, MET302E, PHE301A, SER284E, THR287A, THR287E, THR295E, THR305A, THR305E, VAL290A
• B-C: ALA176B, ALA262B, ALA298B, ALA298C, ALA308B, ALA308C, ALA338C, ALA8C, ARG153B, ARG158B, ARG202B, ARG210C, ARG216C, ARG222C, ARG229B, ARG252B, ARG269B, ARG269C, ARG96C, ASN217C, ASN285B, ASN285C, ASN288B, ASN288C, ASN92C, ASP148B, ASP175B, ASP179B, ASP180B, ASP189B, ASP193B, ASP253B, ASP256B, ASP263B, ASP270B, ASP277B, ASP277C, ASP89C, GLN209C, GLN213C, GLN260B, GLN95C, GLU100C, GLU103C, GLU152B, GLU186B, GLU196B, GLU197B, GLU201B, GLU204C, GLU206C, GLU220C, GLU246B, GLU266B, GLU289B, GLU289C, GLU88C, GLY11C, GLY159B, GLY15C, GLY274B, GLY309B, GLY309C, GLY312B, GLY312C, GLY326C, GLY335C, HIS212C, HIS257B, HIS83C, HIS94C, ILE160B, ILE161B, ILE192B, ILE259B, ILE261B, ILE271B, ILE296B, ILE296C, ILE297B, ILE297C, ILE300B, ILE300C, ILE307B, ILE307C, ILE310B, ILE310C, ILE337B, ILE337C, LEU12C, LEU184B, LEU185B, LEU200B, LEU218C, LEU275B, LEU276B, LEU276C, LEU280B, LEU280C, LEU294B, LEU294C, LEU304B, LEU304C, LEU331C, LEU6C, LEU85C, LYS10C, LYS111C, LYS164B, LYS187B, LYS205C, LYS215C, LYS223C, LYS245B, LYS286B, LYS286C, LYS292B, LYS292C, LYS348B, LYS349B, LYS98C, LYS9C, MET291B, MET291C, MET302B, MET302C, MET334C, MET341B, PHE101C, PHE102C, PHE107C, PHE147B, PHE182B, PHE251B, PHE268B, PHE301B, PHE301C, PHE306B, PHE306C, PHE345B, PRO13C, PRO149B, PRO14C, PRO203B, PRO203C, PRO227C, PRO249B, PRO303B, PRO303C, PRO84C, PRO97C, SER172B, SER273B, SER273C, SER281B, SER282B, SER282C, SER284B, SER284C, SER7C, THR16C, THR207C, THR211C, THR224C, THR247B, THR258B, THR264B, THR267B, THR287B, THR287C, THR295B, THR295C, THR299B, THR299C, THR305B, THR305C, TRP226C, TYR168B, TYR171B, TYR181B, TYR236B, TYR250B, TYR279B, TYR279C, TYR311B, TYR311C, TYR327C, TYR344B, VAL146B, VAL150B, VAL183B, VAL199B, VAL208C, VAL219C, VAL248B, VAL254B, VAL265B, VAL272B, VAL278B, VAL283B, VAL283C, VAL290B, VAL290C, VAL293B, VAL293C, VAL330C, VAL86C, VAL93C, VAL99C
• B-D: ALA298B, ALA298D, ILE297B, LEU280B, LEU280D, LEU294B, LEU294D, MET291B, MET291D, MET302D, PHE301B, SER284D, THR287B, THR287D, THR295D, THR305B, THR305D, VAL290B
• B-E: ALA298B, ALA298E, ILE297E, LEU280B, LEU280E, LEU294B, LEU294E, LYS205E, LYS348B, MET291B, MET291E, MET302B, PHE301E, SER284B, THR287B, THR287E, THR295B, THR305B, THR305E, VAL290E
• C-D: ALA298C, ALA298D, ILE297D, LEU280C, LEU280D, LEU294C, LEU294D, MET291C, MET291D, MET302C, PHE301D, SER284C, THR287C, THR287D, THR295C, THR305C, THR305D, VAL290D
• C-E: ALA176C, ALA262C, ALA298C, ALA298E, ALA308C, ALA308E, ALA338E, ALA8E, ARG153C, ARG158C, ARG202C, ARG210E, ARG216E, ARG222E, ARG229C, ARG252C, ARG269C, ARG269E, ARG5E, ARG96E, ASN217E, ASN285C, ASN285E, ASN288C, ASN288E, ASN92E, ASP148C, ASP175C, ASP179C, ASP180C, ASP189C, ASP193C, ASP253C, ASP256C, ASP263C, ASP270C, ASP277C, ASP277E, ASP89E, GLN209E, GLN213E, GLN260C, GLN95E, GLU100E, GLU103E, GLU152C, GLU186C, GLU196C, GLU197C, GLU201C, GLU204E, GLU206E, GLU220E, GLU246C, GLU266C, GLU289C, GLU289E, GLU88E, GLY11E, GLY159C, GLY15E, GLY274C, GLY274E, GLY309C, GLY309E, GLY312C, GLY312E, GLY335E, HIS212E, HIS257C, HIS83E, HIS94E, ILE160C, ILE161C, ILE192C, ILE259C, ILE261C, ILE271C, ILE296C, ILE296E, ILE297C, ILE297E, ILE300C, ILE300E, ILE307C, ILE307E, ILE310C, ILE310E, ILE337C, LEU12E, LEU184C, LEU185C, LEU195C, LEU200C, LEU218E, LEU275C, LEU275E, LEU276C, LEU276E, LEU280C, LEU280E, LEU294C, LEU294E, LEU304C, LEU304E, LEU331E, LEU6E, LEU85E, LYS10E, LYS111E, LYS164C, LYS187C, LYS205E, LYS215E, LYS223E, LYS245C, LYS286C, LYS286E, LYS292C, LYS292E, LYS348C, LYS349C, LYS349E, LYS98E, LYS9E, MET291C, MET291E, MET302C, MET302E, MET334E, MET341C, PHE101E, PHE102E, PHE107E, PHE147C, PHE182C, PHE251C, PHE268C, PHE301C, PHE301E, PHE306C, PHE306E, PHE345C, PRO13E, PRO149C, PRO14E, PRO203C, PRO203E, PRO227E, PRO249C, PRO303C, PRO303E, PRO84E, PRO97E, SER172C, SER273C, SER273E, SER281C, SER281E, SER282C, SER282E, SER284C, SER284E, SER7E, THR16E, THR207E, THR211E, THR224E, THR247C, THR258C, THR264C, THR267C, THR287C, THR287E, THR295C, THR295E, THR299C, THR299E, THR305C, THR305E, TRP226E, TYR168C, TYR171C, TYR181C, TYR236C, TYR250C, TYR279C, TYR279E, TYR311C, TYR311E, TYR327E, TYR344C, VAL146C, VAL150C, VAL183C, VAL194C, VAL199C, VAL208E, VAL219E, VAL248C, VAL254C, VAL265C, VAL272C, VAL278C, VAL278E, VAL283C, VAL283E, VAL290C, VAL290E, VAL293C, VAL293E, VAL330E, VAL86E, VAL93E, VAL99E
• D-E: ALA176E, ALA262E, ALA298D, ALA298E, ALA308D, ALA308E, ALA338D, ALA8D, ARG153E, ARG158E, ARG202E, ARG210D, ARG216D, ARG222D, ARG229E, ARG252E, ARG269D, ARG269E, ARG5D, ARG96D, ASN217D, ASN285D, ASN285E, ASN288D, ASN288E, ASN92D, ASP148E, ASP175E, ASP179E, ASP180E, ASP189E, ASP190E, ASP193E, ASP253E, ASP256E, ASP263E, ASP270E, ASP277D, ASP277E, ASP89D, GLN209D, GLN213D, GLN260E, GLN95D, GLU100D, GLU103D, GLU152E, GLU186E, GLU196E, GLU197E, GLU201E, GLU204D, GLU206D, GLU220D, GLU246E, GLU266E, GLU289D, GLU289E, GLU88D, GLY11D, GLY159E, GLY15D, GLY274E, GLY309D, GLY309E, GLY312D, GLY312E, GLY335D, HIS212D, HIS257E, HIS83D, HIS94D, ILE160E, ILE161E, ILE192E, ILE259E, ILE261E, ILE271E, ILE296D, ILE296E, ILE297D, ILE297E, ILE300D, ILE300E, ILE307D, ILE307E, ILE310E, ILE337E, LEU12D, LEU177E, LEU184E, LEU185E, LEU195E, LEU200E, LEU218D, LEU221D, LEU275D, LEU275E, LEU276D, LEU276E, LEU280D, LEU280E, LEU294D, LEU294E, LEU304D, LEU304E, LEU331D, LEU6D, LEU85D, LYS10D, LYS111D, LYS164E, LYS205D, LYS215D, LYS223D, LYS245E, LYS286D, LYS286E, LYS292D, LYS292E, LYS348E, LYS349E, LYS98D, LYS9D, MET291D, MET291E, MET302D, MET302E, MET334D, MET341E, PHE101D, PHE102D, PHE107D, PHE147E, PHE182E, PHE251E, PHE268E, PHE301D, PHE301E, PHE306D, PHE306E, PHE345E, PRO13D, PRO149E, PRO14D, PRO203D, PRO203E, PRO227D, PRO249E, PRO303D, PRO303E, PRO84D, PRO97D, SER172E, SER273D, SER273E, SER281D, SER281E, SER282D, SER282E, SER284D, SER284E, SER7D, THR16D, THR207D, THR211D, THR224D, THR247E, THR258E, THR264E, THR267E, THR287D, THR287E, THR295D, THR295E, THR299D, THR299E, THR305D, THR305E, TRP226D, TYR168E, TYR171E, TYR181E, TYR236E, TYR250E, TYR255E, TYR279D, TYR279E, TYR311D, TYR311E, TYR327D, TYR344E, VAL146E, VAL150E, VAL178E, VAL183E, VAL199E, VAL208D, VAL219D, VAL248E, VAL254E, VAL265E, VAL272E, VAL278D, VAL278E, VAL283D, VAL283E, VAL290D, VAL290E, VAL293D, VAL293E, VAL330D, VAL86D, VAL93D, VAL99D
• D-I: ARG24D, ARG24I, ARG69D, ARG69I, ASN118D, ASN118I, ASP116D, ASP116I, ASP26D, ASP26I, ASP46D, ASP46I, ASP71D, ASP71I, GLU121D, GLU121I, GLU123D, GLU123I, GLU141I, GLU25D, GLU25I, GLU28D, HIS68D, HIS68I, ILE143D, LEU119D, LEU119I, LYS117I, LYS142D, LYS142I, LYS22D, LYS22I, PHE27D, PHE27I, THR44D, THR45D, THR45I, TYR23D, TYR23I, VAL72D, VAL72I
• E-J: ARG155E, ARG155J, ARG158E, ARG158J, ASN118E, ASN118J, ASP116E, ASP116J, GLU152E, GLU152J, HIS120E, HIS120J, LEU119E, LEU119J, LYS117E, LYS117J, TYR156E, TYR156J, VAL194E
• F-G: ALA176F, ALA262F, ALA298F, ALA298G, ALA308F, ALA308G, ALA338G, ALA8G, ARG153F, ARG158F, ARG202F, ARG210G, ARG216G, ARG222G, ARG229F, ARG252F, ARG269F, ARG269G, ARG322F, ARG322G, ARG5G, ARG96G, ASN217G, ASN285F, ASN285G, ASN288F, ASN288G, ASN314G, ASN92G, ASP148F, ASP175F, ASP179F, ASP180F, ASP189F, ASP190F, ASP193F, ASP253F, ASP256F, ASP263F, ASP270F, ASP277F, ASP277G, ASP89G, GLN209G, GLN213G, GLN260F, GLN95G, GLU100G, GLU103G, GLU152F, GLU186F, GLU196F, GLU197F, GLU201F, GLU204G, GLU206G, GLU220G, GLU246F, GLU266F, GLU289F, GLU289G, GLU320F, GLU88G, GLY11G, GLY159F, GLY15G, GLY274F, GLY309F, GLY309G, GLY312F, GLY312G, GLY326G, GLY335G, HIS212G, HIS257F, HIS83G, HIS94G, ILE160F, ILE161F, ILE192F, ILE259F, ILE261F, ILE271F, ILE296F, ILE296G, ILE297F, ILE297G, ILE300F, ILE300G, ILE307F, ILE307G, ILE310F, ILE310G, ILE337F, ILE337G, LEU12G, LEU184F, LEU185F, LEU200F, LEU218G, LEU275F, LEU276F, LEU276G, LEU280F, LEU280G, LEU294F, LEU294G, LEU304F, LEU304G, LEU321F, LEU331G, LEU6G, LEU85G, LYS10G, LYS111G, LYS164F, LYS205G, LYS215G, LYS223G, LYS245F, LYS286F, LYS286G, LYS292F, LYS292G, LYS324G, LYS348F, LYS349F, LYS98G, LYS9G, MET291F, MET291G, MET302F, MET302G, MET313F, MET313G, MET318F, MET318G, MET334G, MET341F, PHE101G, PHE102G, PHE107G, PHE147F, PHE182F, PHE251F, PHE268F, PHE301F, PHE301G, PHE306F, PHE306G, PHE345F, PRO13G, PRO149F, PRO14G, PRO203F, PRO203G, PRO227G, PRO249F, PRO303F, PRO303G, PRO319F, PRO328G, PRO84G, PRO97G, SER172F, SER273F, SER273G, SER281F, SER281G, SER282F, SER282G, SER284F, SER284G, SER7G, THR16G, THR207G, THR211G, THR224G, THR247F, THR258F, THR264F, THR267F, THR287F, THR287G, THR295F, THR295G, THR299F, THR299G, THR305F, THR305G, TRP226G, TRP323G, TRP325G, TYR168F, TYR171F, TYR181F, TYR236F, TYR250F, TYR255F, TYR279F, TYR279G, TYR311F, TYR311G, TYR317F, TYR317G, TYR327G, TYR344F, VAL146F, VAL150F, VAL183F, VAL199F, VAL208G, VAL219G, VAL248F, VAL254F, VAL265F, VAL272F, VAL278F, VAL283F, VAL283G, VAL290F, VAL290G, VAL293F, VAL293G, VAL329G, VAL330G, VAL86G, VAL93G, VAL99G
• F-H: ALA298F, ALA298H, ILE297H, LEU280F, LEU280H, LEU294F, LEU294H, MET291F, MET291H, MET302F, MET313F, PHE301H, SER284F, THR287F, THR287H, THR295F, THR305F, THR305H, TYR327H, VAL290H
• F-I: ALA176I, ALA262I, ALA298F, ALA298I, ALA308F, ALA308I, ALA338F, ALA8F, ARG153I, ARG158I, ARG202I, ARG210F, ARG216F, ARG222F, ARG229I, ARG252I, ARG269F, ARG269I, ARG322F, ARG322I, ARG5F, ARG96F, ASN217F, ASN285F, ASN285I, ASN288F, ASN288I, ASN92F, ASP148I, ASP175I, ASP179I, ASP180I, ASP189I, ASP190I, ASP193I, ASP253I, ASP256I, ASP263I, ASP270I, ASP277F, ASP277I, ASP89F, GLN209F, GLN213F, GLN260I, GLN95F, GLU100F, GLU103F, GLU152I, GLU186I, GLU196I, GLU197I, GLU201I, GLU204F, GLU206F, GLU220F, GLU246I, GLU266I, GLU289F, GLU289I, GLU320F, GLU320I, GLU88F, GLY11F, GLY159I, GLY15F, GLY274F, GLY274I, GLY309F, GLY309I, GLY312F, GLY312I, GLY326F, GLY335F, HIS212F, HIS257I, HIS83F, HIS94F, ILE160I, ILE161I, ILE192I, ILE259I, ILE261I, ILE271I, ILE296F, ILE296I, ILE297F, ILE297I, ILE300F, ILE300I, ILE307F, ILE307I, ILE310F, ILE310I, ILE337F, ILE337I, LEU12F, LEU184I, LEU185I, LEU195I, LEU200I, LEU218F, LEU275F, LEU275I, LEU276F, LEU276I, LEU280F, LEU280I, LEU294F, LEU294I, LEU304F, LEU304I, LEU321F, LEU321I, LEU331F, LEU6F, LEU85F, LYS10F, LYS111F, LYS164I, LYS187I, LYS205F, LYS215F, LYS223F, LYS245I, LYS286F, LYS286I, LYS292F, LYS292I, LYS324F, LYS348I, LYS349F, LYS349I, LYS98F, LYS9F, MET291F, MET291I, MET302F, MET302I, MET313I, MET318I, MET334F, MET341I, PHE101F, PHE102F, PHE107F, PHE147I, PHE182I, PHE251I, PHE268I, PHE301F, PHE301I, PHE306F, PHE306I, PHE345I, PRO13F, PRO149I, PRO14F, PRO203F, PRO203I, PRO227F, PRO249I, PRO303F, PRO303I, PRO319F, PRO319I, PRO328F, PRO84F, PRO97F, SER172I, SER273F, SER273I, SER281F, SER281I, SER282F, SER282I, SER284F, SER284I, SER7F, THR16F, THR207F, THR211F, THR224F, THR247I, THR258I, THR264I, THR267I, THR287F, THR287I, THR295F, THR295I, THR299F, THR299I, THR305F, THR305I, TRP226F, TRP323F, TRP325F, TYR168I, TYR171I, TYR181I, TYR236I, TYR250I, TYR255I, TYR279F, TYR279I, TYR311F, TYR311I, TYR317I, TYR327F, TYR344I, VAL146I, VAL150I, VAL183I, VAL194I, VAL199I, VAL208F, VAL219F, VAL248I, VAL254I, VAL265I, VAL272I, VAL278F, VAL278I, VAL283F, VAL283I, VAL290F, VAL290I, VAL293F, VAL293I, VAL329F, VAL330F, VAL86F, VAL93F, VAL99F
• F-J: ALA298F, ALA298J, ILE297F, LEU280F, LEU280J, LEU294F, LEU294J, MET291F, MET291J, MET302J, MET313J, PHE301F, SER284J, THR287F, THR287J, THR295J, THR305F, THR305J, TYR327F, VAL290F
• G-H: ALA176G, ALA262G, ALA298G, ALA298H, ALA308G, ALA308H, ALA338H, ALA8H, ARG153G, ARG158G, ARG202G, ARG210H, ARG216H, ARG222H, ARG229G, ARG252G, ARG269G, ARG269H, ARG322H, ARG96H, ASN217H, ASN285G, ASN285H, ASN288G, ASN288H, ASN314G, ASN92H, ASP148G, ASP175G, ASP179G, ASP180G, ASP189G, ASP193G, ASP253G, ASP256G, ASP263G, ASP270G, ASP277G, ASP277H, ASP89H, GLN209H, GLN213H, GLN260G, GLN95H, GLU100H, GLU103H, GLU152G, GLU186G, GLU196G, GLU197G, GLU201G, GLU204H, GLU206H, GLU220H, GLU246G, GLU266G, GLU289G, GLU289H, GLU316G, GLU320H, GLU88H, GLY11H, GLY159G, GLY15H, GLY274G, GLY309G, GLY309H, GLY312G, GLY312H, GLY326H, GLY335H, HIS212H, HIS257G, HIS83H, HIS94H, ILE160G, ILE161G, ILE192G, ILE259G, ILE261G, ILE271G, ILE296G, ILE296H, ILE297G, ILE297H, ILE300G, ILE300H, ILE307G, ILE307H, ILE310G, ILE310H, ILE337G, ILE337H, LEU12H, LEU184G, LEU185G, LEU200G, LEU218H, LEU221H, LEU275G, LEU275H, LEU276G, LEU276H, LEU280G, LEU280H, LEU294G, LEU294H, LEU304G, LEU304H, LEU321H, LEU331H, LEU6H, LEU85H, LYS10H, LYS111H, LYS164G, LYS205H, LYS215H, LYS223H, LYS245G, LYS286G, LYS286H, LYS292G, LYS292H, LYS324H, LYS348G, LYS349G, LYS98H, LYS9H, MET291G, MET291H, MET302G, MET302H, MET313G, MET313H, MET318G, MET334H, MET341G, PHE101H, PHE102H, PHE107H, PHE147G, PHE182G, PHE251G, PHE268G, PHE301G, PHE301H, PHE306G, PHE306H, PHE315G, PHE345G, PRO13H, PRO149G, PRO14H, PRO203G, PRO203H, PRO227H, PRO249G, PRO303G, PRO303H, PRO328H, PRO84H, PRO97H, SER172G, SER273G, SER273H, SER281G, SER281H, SER282G, SER282H, SER284G, SER284H, SER7H, THR16H, THR207H, THR211H, THR224H, THR247G, THR258G, THR264G, THR267G, THR287G, THR287H, THR295G, THR295H, THR299G, THR299H, THR305G, THR305H, TRP226H, TRP323H, TRP325H, TYR168G, TYR171G, TYR181G, TYR236G, TYR250G, TYR255G, TYR279G, TYR279H, TYR311G, TYR311H, TYR317G, TYR327H, TYR344G, VAL146G, VAL150G, VAL183G, VAL199G, VAL208H, VAL219H, VAL248G, VAL254G, VAL265G, VAL272G, VAL278G, VAL283G, VAL283H, VAL290G, VAL290H, VAL293G, VAL293H, VAL330H, VAL86H, VAL93H, VAL99H
• G-I: ALA298G, ALA298I, ILE297G, LEU280G, LEU280I, LEU294G, LEU294I, MET291G, MET291I, MET302I, PHE301G, SER284I, THR287G, THR287I, THR295I, THR305G, THR305I, VAL290G
• G-J: ALA298G, ALA298J, ILE297J, LEU280G, LEU280J, LEU294G, LEU294J, LYS205J, LYS348G, MET291G, MET291J, MET302G, MET313G, PHE301J, SER284G, THR287G, THR287J, THR295G, THR305G, THR305J, TYR327J, VAL290J
• H-I: ALA298H, ALA298I, ILE297I, LEU280H, LEU280I, LEU294H, LEU294I, LYS205I, LYS348H, MET291H, MET291I, MET302H, PHE301I, THR287H, THR287I, THR295H, THR305H, THR305I, VAL290I
• H-J: ALA176H, ALA262H, ALA298H, ALA298J, ALA308H, ALA308J, ALA332J, ALA338J, ALA8J, ARG153H, ARG158H, ARG202H, ARG210J, ARG216J, ARG222J, ARG229H, ARG252H, ARG269H, ARG269J, ARG322H, ARG5J, ARG96J, ASN217J, ASN285H, ASN285J, ASN288H, ASN288J, ASN92J, ASP148H, ASP175H, ASP179H, ASP180H, ASP189H, ASP193H, ASP253H, ASP256H, ASP263H, ASP270H, ASP277H, ASP277J, ASP89J, GLN209J, GLN213J, GLN260H, GLN95J, GLU100J, GLU103J, GLU152H, GLU186H, GLU196H, GLU197H, GLU201H, GLU204J, GLU206J, GLU220J, GLU246H, GLU266H, GLU289H, GLU289J, GLU320H, GLU88J, GLY11J, GLY159H, GLY15J, GLY274H, GLY309H, GLY309J, GLY312H, GLY312J, GLY335J, HIS212J, HIS257H, HIS83J, HIS94J, ILE160H, ILE161H, ILE192H, ILE259H, ILE261H, ILE271H, ILE296H, ILE296J, ILE297H, ILE297J, ILE300H, ILE300J, ILE307H, ILE307J, ILE310H, ILE310J, ILE337H, LEU12J, LEU184H, LEU185H, LEU200H, LEU218J, LEU275H, LEU276H, LEU276J, LEU280H, LEU280J, LEU294H, LEU294J, LEU304H, LEU304J, LEU321H, LEU331J, LEU6J, LEU85J, LYS10J, LYS111J, LYS164H, LYS187H, LYS205J, LYS215J, LYS223J, LYS245H, LYS286H, LYS286J, LYS292H, LYS292J, LYS348H, LYS349H, LYS98J, LYS9J, MET291H, MET291J, MET302H, MET302J, MET313H, MET313J, MET334J, MET341H, PHE101J, PHE102J, PHE107J, PHE147H, PHE182H, PHE251H, PHE268H, PHE301H, PHE301J, PHE306H, PHE306J, PHE315J, PHE345H, PRO13J, PRO149H, PRO14J, PRO203H, PRO203J, PRO227J, PRO249H, PRO303H, PRO303J, PRO328J, PRO84J, PRO97J, SER172H, SER234J, SER273H, SER281H, SER282H, SER282J, SER284H, SER284J, SER7J, THR16J, THR207J, THR211J, THR224J, THR247H, THR258H, THR264H, THR267H, THR287H, THR287J, THR295H, THR295J, THR299H, THR299J, THR305H, THR305J, TRP226J, TYR168H, TYR171H, TYR181H, TYR236H, TYR250H, TYR255H, TYR279H, TYR279J, TYR311H, TYR311J, TYR327J, TYR344H, VAL146H, VAL150H, VAL183H, VAL199H, VAL208J, VAL219J, VAL248H, VAL254H, VAL265H, VAL272H, VAL278H, VAL283H, VAL283J, VAL290H, VAL290J, VAL293H, VAL293J, VAL330J, VAL86J, VAL93J, VAL99J
• I-J: ALA176J, ALA262J, ALA298I, ALA298J, ALA308I, ALA308J, ALA338I, ALA8I, ARG153J, ARG158J, ARG202J, ARG210I, ARG216I, ARG222I, ARG229J, ARG252J, ARG269I, ARG269J, ARG322I, ARG96I, ASN217I, ASN285I, ASN285J, ASN288I, ASN288J, ASN314J, ASN92I, ASP148J, ASP175J, ASP179J, ASP180J, ASP189J, ASP193J, ASP253J, ASP256J, ASP263J, ASP270J, ASP277I, ASP277J, ASP89I, GLN209I, GLN213I, GLN260J, GLN95I, GLU100I, GLU103I, GLU152J, GLU186J, GLU196J, GLU197J, GLU201J, GLU204I, GLU206I, GLU220I, GLU246J, GLU266J, GLU289I, GLU289J, GLU320I, GLU88I, GLY11I, GLY159J, GLY15I, GLY274J, GLY309I, GLY309J, GLY312I, GLY312J, GLY326I, GLY335I, HIS212I, HIS257J, HIS83I, HIS94I, ILE160J, ILE161J, ILE192J, ILE259J, ILE261J, ILE271J, ILE296I, ILE296J, ILE297I, ILE297J, ILE300I, ILE300J, ILE307I, ILE307J, ILE310I, ILE310J, ILE337I, ILE337J, LEU12I, LEU184J, LEU185J, LEU195J, LEU200J, LEU218I, LEU275I, LEU275J, LEU276I, LEU276J, LEU280I, LEU280J, LEU294I, LEU294J, LEU304I, LEU304J, LEU321I, LEU331I, LEU85I, LYS10I, LYS111I, LYS164J, LYS187J, LYS205I, LYS215I, LYS223I, LYS245J, LYS286I, LYS286J, LYS292I, LYS292J, LYS324I, LYS348J, LYS349J, LYS98I, LYS9I, MET291I, MET291J, MET302I, MET302J, MET313I, MET313J, MET318I, MET334I, MET341J, PHE101I, PHE102I, PHE107I, PHE147J, PHE182J, PHE251J, PHE268J, PHE301I, PHE301J, PHE306I, PHE306J, PHE315J, PHE345J, PRO13I, PRO149J, PRO14I, PRO203I, PRO203J, PRO227I, PRO249J, PRO303I, PRO303J, PRO319I, PRO328I, PRO84I, PRO97I, SER172J, SER273I, SER273J, SER281I, SER281J, SER282I, SER282J, SER284I, SER284J, SER7I, THR16I, THR207I, THR211I, THR224I, THR247J, THR258J, THR264J, THR267J, THR287I, THR287J, THR295I, THR295J, THR299I, THR299J, THR305I, THR305J, TRP226I, TRP323I, TRP325I, TYR168J, TYR171J, TYR181J, TYR236J, TYR250J, TYR255J, TYR279I, TYR279J, TYR311I, TYR311J, TYR317I, TYR327I, TYR344J, VAL146J, VAL150J, VAL183J, VAL199J, VAL208I, VAL219I, VAL248J, VAL254J, VAL265J, VAL272J, VAL278J, VAL283I, VAL283J, VAL290I, VAL290J, VAL293I, VAL293J, VAL329I, VAL330I, VAL86I, VAL93I, VAL99I