2ISK

blub bound to flavin anion (charge transfer complex)

• Total interactions analyzed: 28
• Total true interactions: 15
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 30
  • Norm. En. per Res.: -9.3874
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-350.9606	-137.0195	-1480.33	-1968.3101	364	94	61	56915	10	73	70
A-C	-9.848	9.5558	-64.4159	-64.7082	40	5	0	2462	0	20	14
A-D	-24.0696	-180.0314	-77.5213	-281.6223	30	3	0	2964	12	14	15
A-E	-24.7749	1.9363	-89.9062	-112.7448	47	3	0	3524	7	31	26
A-F	0.0	0.0	-0.1269	-0.1269	3	0	0	24	0	1	0
B-C	0.0	0.0	-0.3255	-0.3255	9	0	0	90	0	4	3
B-D	-11.5723	6.9458	-63.9972	-68.6237	40	4	0	2448	0	21	14
B-E	-8.7394	9.7769	-52.8828	-51.8453	25	3	0	2026	0	9	9
C-D	-324.45	-129.4319	-1533.56	-1987.4419	366	85	62	56483	11	72	68
E-F	-368.6689	-114.8793	-1477.76	-1961.3082	363	81	60	56130	11	73	70
E-G	-16.303	8.0233	-62.5503	-70.83	38	9	0	2547	0	19	14
E-H	0.0	0.0	-0.4179	-0.4179	11	0	0	106	0	5	4
F-G	-24.6312	-173.335	-69.7132	-267.6794	30	2	0	2840	12	16	12
F-H	-8.5436	7.3038	-71.1916	-72.4314	42	6	0	2540	0	21	15
G-H	-327.5167	-125.0046	-1521.82	-1974.3413	362	79	60	56391	12	73	68

Interface residues

• A-B: ALA11A, ALA11B, ALA129A, ALA129B, ALA12A, ALA12B, ALA148A, ALA148B, ALA14A, ALA14B, ALA155A, ALA155B, ALA156A, ALA156B, ALA158A, ALA158B, ALA188A, ALA188B, ALA205A, ALA205B, ALA206A, ALA206B, ALA21A, ALA21B, ALA22A, ALA22B, ALA26A, ALA26B, ALA48A, ALA48B, ALA53A, ALA53B, ALA54A, ALA54B, ALA57A, ALA57B, ALA83A, ALA83B, ALA87A, ALA87B, ALA91A, ALA91B, ALA92A, ALA92B, ARG124A, ARG124B, ARG126A, ARG126B, ARG134A, ARG134B, ARG157A, ARG157B, ARG197A, ARG197B, ARG20A, ARG20B, ARG210A, ARG210B, ARG212A, ARG212B, ARG227A, ARG227B, ARG25A, ARG25B, ARG30A, ARG30B, ARG31A, ARG31B, ARG34A, ARG34B, ARG49A, ARG49B, ARG72A, ARG72B, ARG77A, ARG77B, ARG86A, ARG86B, ARG99A, ARG99B, ASN137A, ASN137B, ASN151A, ASN151B, ASN67A, ASN67B, ASN88A, ASN88B, ASP123A, ASP123B, ASP141A, ASP141B, ASP18A, ASP18B, ASP196A, ASP196B, ASP217A, ASP217B, ASP32A, ASP32B, ASP35A, ASP35B, ASP74A, ASP74B, ASP89A, ASP89B, CYS119A, CYS119B, CYS122A, CYS122B, CYS147A, CYS147B, GLN139A, GLN139B, GLN150A, GLN150B, GLN200A, GLN200B, GLN211A, GLN211B, GLN56A, GLN56B, GLN64A, GLN64B, GLN73A, GLN73B, GLU159A, GLU159B, GLU171A, GLU171B, GLU173A, GLU173B, GLU185A, GLU185B, GLU19A, GLU19B, GLU201A, GLU201B, GLU203A, GLU203B, GLU216A, GLU216B, GLU221A, GLU221B, GLU222A, GLU222B, GLU28A, GLU28B, GLU36A, GLU36B, GLU44A, GLU44B, GLU45A, GLU75A, GLU75B, GLU90A, GLU90B, GLU93A, GLU93B, GLY127A, GLY127B, GLY128A, GLY128B, GLY133A, GLY133B, GLY13A, GLY13B, GLY160A, GLY160B, GLY164B, GLY179A, GLY179B, GLY223A, GLY223B, GLY225A, GLY225B, GLY52A, GLY52B, GLY61A, GLY61B, HIS136A, HIS136B, HIS170A, HIS170B, HIS183A, HIS183B, HIS55A, HIS55B, ILE118A, ILE118B, ILE168A, ILE168B, ILE177A, ILE177B, ILE180A, ILE180B, ILE186A, ILE186B, ILE27A, ILE27B, ILE47A, ILE47B, LEU106A, LEU106B, LEU108A, LEU108B, LEU116A, LEU116B, LEU132A, LEU132B, LEU142A, LEU142B, LEU152A, LEU152B, LEU154A, LEU154B, LEU178A, LEU178B, LEU190B, LEU198A, LEU198B, LEU204A, LEU204B, LEU213A, LEU213B, LEU215A, LEU215B, LEU218A, LEU218B, LEU38B, LEU46A, LEU46B, LEU50A, LEU50B, LEU51A, LEU51B, LEU70A, LEU70B, LEU9A, LEU9B, LYS102A, LYS102B, LYS107A, LYS107B, LYS175A, LYS175B, LYS207A, LYS207B, MET140A, MET140B, MET63A, MET63B, MET94A, MET94B, PHE15A, PHE15B, PHE169A, PHE169B, PHE194B, PHE220A, PHE220B, PHE62A, PHE62B, PHE68A, PHE68B, PHE84A, PHE84B, PHE95A, PHE95B, PRO138A, PRO138B, PRO181A, PRO181B, PRO202A, PRO202B, PRO214A, PRO214B, PRO58A, PRO58B, PRO65A, PRO65B, SER117A, SER117B, SER144A, SER144B, SER167A, SER167B, SER16A, SER16B, SER17A, SER17B, SER59A, SER59B, SER96A, SER96B, THR10A, THR10B, THR121A, THR121B, THR125A, THR125B, THR135A, THR135B, THR145A, THR145B, THR29A, THR29B, THR76A, THR76B, TRP153A, TRP153B, TRP165A, TRP165B, TRP189A, TRP189B, TRP209A, TRP209B, TRP224A, TRP224B, TRP66A, TRP66B, TYR103A, TYR103B, TYR143A, TYR143B, TYR199A, TYR199B, TYR24A, TYR24B, VAL120A, VAL120B, VAL130A, VAL130B, VAL131A, VAL131B, VAL146A, VAL146B, VAL149A, VAL149B, VAL161A, VAL161B, VAL163A, VAL166A, VAL166B, VAL184A, VAL184B, VAL187A, VAL187B, VAL195A, VAL195B, VAL219A, VAL219B, VAL226A, VAL226B, VAL23A, VAL23B, VAL33A, VAL33B, VAL60A, VAL60B, VAL69A, VAL69B, VAL71A, VAL71B
• A-C: ALA129C, ALA48C, ARG124C, ARG126C, ARG134C, ARG227A, ARG99A, ASP123C, ASP182C, ASP217A, GLN211A, GLN64C, GLU216A, GLU221A, GLU44C, GLU45C, GLU98A, GLY127C, GLY128C, GLY225A, GLY61C, GLY97A, HIS183C, LEU132C, LEU215A, LEU218A, MET63C, PHE220A, PHE62C, PRO181C, PRO214A, PRO65C, SER96A, THR125C, TRP224A, VAL130C, VAL131C, VAL184C, VAL219A, VAL226A
• A-D: ALA205A, ALA205D, ARG210A, ARG210D, ARG212A, ARG212D, ARG227A, ARG227D, ARG99A, ARG99D, ASP217A, ASP217D, GLN211A, GLN211D, GLU201A, GLU201D, GLU216A, GLU216D, LEU213A, LEU213D, LEU215A, LEU215D, LEU218A, LEU218D, PHE95A, PHE95D, PRO214A, PRO214D, TRP209A, TRP209D
• A-E: ALA156A, ALA158A, ALA176E, ALA83E, ALA87E, ALA92E, ARG104E, ARG157A, ARG197A, ARG25A, ARG49A, ARG86E, ASN88E, ASP196A, ASP89E, GLN82E, GLN85E, GLU159A, GLU173E, GLU40A, GLU44A, GLU45A, GLU75E, GLU78E, GLU90E, GLU93E, GLY160A, GLY193A, HIS170E, ILE174E, ILE177E, LEU38A, LEU42A, LEU46A, LYS79E, PHE169E, PHE194A, PHE84E, PRO115A, PRO39A, PRO41A, SER172E, SER43A, TRP81E, VAL161A, VAL195A, VAL80E
• A-F: GLU40A, HIS136F, PRO41A
• B-C: ALA129C, ASP182C, GLU44B, GLY179B, GLY179C, HIS183B, HIS183C, PRO181B, PRO181C
• B-D: ALA129B, ALA48B, ARG124B, ARG126B, ARG134B, ARG227D, ARG99D, ASP123B, ASP182B, ASP217D, GLN211D, GLN64B, GLU216D, GLU221D, GLU44B, GLU45B, GLU98D, GLY127B, GLY128B, GLY225D, GLY61B, GLY97D, HIS183B, LEU132B, LEU215D, LEU218D, MET63B, PHE220D, PHE62B, PRO181B, PRO214D, PRO65B, SER96D, THR125B, TRP224D, VAL130B, VAL131B, VAL184B, VAL219D, VAL226D
• B-E: ALA11B, ALA12B, ALA14B, ALA176E, ARG112E, ARG20B, ARG77E, ARG86E, ASP18B, ASP74E, GLN82E, GLN85E, GLU19B, GLU75E, GLU78E, GLY13B, ILE177E, LYS79E, PHE15B, SER16B, SER17B, THR10B, THR76E, TRP81E, VAL80E
• C-D: ALA11C, ALA11D, ALA129C, ALA129D, ALA12C, ALA12D, ALA148C, ALA148D, ALA14C, ALA14D, ALA155C, ALA155D, ALA156C, ALA156D, ALA158C, ALA158D, ALA188C, ALA188D, ALA205C, ALA205D, ALA206C, ALA206D, ALA21C, ALA21D, ALA22C, ALA22D, ALA26C, ALA26D, ALA48C, ALA48D, ALA53C, ALA53D, ALA54C, ALA54D, ALA57C, ALA57D, ALA83C, ALA83D, ALA87C, ALA87D, ALA91C, ALA91D, ALA92C, ALA92D, ARG124C, ARG124D, ARG126C, ARG126D, ARG134C, ARG134D, ARG157C, ARG157D, ARG197C, ARG197D, ARG20C, ARG20D, ARG210C, ARG210D, ARG212C, ARG212D, ARG227C, ARG227D, ARG25C, ARG25D, ARG30C, ARG30D, ARG31C, ARG31D, ARG34C, ARG34D, ARG49C, ARG49D, ARG72C, ARG72D, ARG77C, ARG77D, ARG86C, ARG86D, ARG99C, ARG99D, ASN137C, ASN137D, ASN151C, ASN151D, ASN67C, ASN67D, ASN88C, ASN88D, ASP123C, ASP123D, ASP141C, ASP141D, ASP18C, ASP18D, ASP196C, ASP196D, ASP217C, ASP217D, ASP32C, ASP32D, ASP35C, ASP35D, ASP74C, ASP74D, ASP89C, ASP89D, CYS119C, CYS119D, CYS122C, CYS122D, CYS147C, CYS147D, GLN139C, GLN139D, GLN150C, GLN150D, GLN200C, GLN200D, GLN211C, GLN211D, GLN56C, GLN56D, GLN64C, GLN64D, GLN73C, GLN73D, GLU159C, GLU159D, GLU171C, GLU171D, GLU173D, GLU185C, GLU185D, GLU19C, GLU19D, GLU201C, GLU201D, GLU203C, GLU203D, GLU216C, GLU216D, GLU221C, GLU221D, GLU222C, GLU222D, GLU28C, GLU28D, GLU36C, GLU36D, GLU44C, GLU44D, GLU45C, GLU45D, GLU75C, GLU75D, GLU90C, GLU90D, GLU93C, GLU93D, GLY127C, GLY127D, GLY128C, GLY128D, GLY133C, GLY133D, GLY13C, GLY13D, GLY160C, GLY160D, GLY164C, GLY164D, GLY179C, GLY179D, GLY223C, GLY223D, GLY225C, GLY225D, GLY52C, GLY52D, GLY61C, GLY61D, HIS136C, HIS136D, HIS170C, HIS170D, HIS183C, HIS183D, HIS55C, HIS55D, ILE118C, ILE118D, ILE168C, ILE168D, ILE177C, ILE177D, ILE180C, ILE180D, ILE186C, ILE186D, ILE27C, ILE27D, ILE47C, ILE47D, LEU106C, LEU106D, LEU108C, LEU108D, LEU116C, LEU116D, LEU132C, LEU132D, LEU142C, LEU142D, LEU152C, LEU152D, LEU154C, LEU154D, LEU178C, LEU178D, LEU198C, LEU198D, LEU204C, LEU204D, LEU213C, LEU213D, LEU215C, LEU215D, LEU218C, LEU218D, LEU38C, LEU38D, LEU46C, LEU46D, LEU50C, LEU50D, LEU51C, LEU51D, LEU70C, LEU70D, LEU9C, LEU9D, LYS102C, LYS102D, LYS107C, LYS107D, LYS175C, LYS175D, LYS207C, LYS207D, MET140C, MET140D, MET63C, MET63D, MET94C, MET94D, PHE15C, PHE15D, PHE169C, PHE169D, PHE194C, PHE194D, PHE220C, PHE220D, PHE62C, PHE62D, PHE68C, PHE68D, PHE84C, PHE84D, PHE95C, PHE95D, PRO138C, PRO138D, PRO181C, PRO181D, PRO202C, PRO202D, PRO214C, PRO214D, PRO58C, PRO58D, PRO65C, PRO65D, SER117C, SER117D, SER144C, SER144D, SER167C, SER167D, SER16C, SER16D, SER17C, SER59C, SER59D, SER96C, SER96D, THR10C, THR10D, THR121C, THR121D, THR125C, THR125D, THR135C, THR135D, THR145C, THR145D, THR29C, THR29D, THR76C, THR76D, TRP153C, TRP153D, TRP165C, TRP165D, TRP189C, TRP189D, TRP209C, TRP209D, TRP224C, TRP224D, TRP66C, TRP66D, TYR103C, TYR103D, TYR143C, TYR143D, TYR199C, TYR199D, TYR24C, TYR24D, VAL120C, VAL120D, VAL130C, VAL130D, VAL131C, VAL131D, VAL146C, VAL146D, VAL149C, VAL149D, VAL161C, VAL161D, VAL163C, VAL163D, VAL166C, VAL166D, VAL184C, VAL184D, VAL187C, VAL187D, VAL195C, VAL195D, VAL219C, VAL219D, VAL226C, VAL226D, VAL23C, VAL23D, VAL33C, VAL33D, VAL60C, VAL60D, VAL69C, VAL69D, VAL71C, VAL71D
• E-F: ALA11E, ALA11F, ALA129E, ALA129F, ALA12E, ALA12F, ALA148E, ALA148F, ALA14E, ALA14F, ALA155E, ALA155F, ALA156E, ALA156F, ALA158E, ALA158F, ALA188E, ALA188F, ALA205E, ALA205F, ALA206E, ALA206F, ALA21E, ALA21F, ALA22E, ALA22F, ALA26E, ALA26F, ALA48E, ALA48F, ALA53E, ALA53F, ALA54E, ALA54F, ALA57E, ALA57F, ALA83E, ALA83F, ALA87E, ALA87F, ALA91E, ALA91F, ALA92E, ALA92F, ARG124E, ARG124F, ARG126E, ARG126F, ARG134E, ARG134F, ARG157E, ARG157F, ARG197E, ARG197F, ARG20E, ARG20F, ARG210E, ARG210F, ARG212E, ARG212F, ARG227E, ARG227F, ARG25E, ARG25F, ARG30E, ARG30F, ARG31E, ARG31F, ARG34E, ARG34F, ARG49E, ARG49F, ARG72E, ARG72F, ARG77E, ARG77F, ARG86E, ARG86F, ARG99E, ARG99F, ASN137E, ASN137F, ASN151E, ASN151F, ASN67E, ASN67F, ASN88E, ASN88F, ASP123E, ASP123F, ASP141E, ASP141F, ASP18E, ASP18F, ASP196E, ASP196F, ASP217E, ASP217F, ASP32E, ASP32F, ASP35E, ASP35F, ASP74E, ASP74F, ASP89E, ASP89F, CYS119E, CYS119F, CYS122E, CYS122F, CYS147E, CYS147F, GLN139E, GLN139F, GLN150E, GLN150F, GLN200E, GLN200F, GLN211E, GLN211F, GLN56E, GLN56F, GLN64E, GLN64F, GLN73E, GLN73F, GLU159E, GLU159F, GLU171E, GLU171F, GLU173E, GLU185E, GLU185F, GLU19E, GLU19F, GLU201E, GLU201F, GLU203E, GLU203F, GLU216E, GLU216F, GLU221E, GLU221F, GLU222E, GLU222F, GLU28E, GLU28F, GLU36E, GLU36F, GLU44E, GLU44F, GLU45F, GLU75E, GLU75F, GLU90E, GLU90F, GLU93E, GLU93F, GLY127E, GLY127F, GLY128E, GLY128F, GLY133E, GLY133F, GLY13E, GLY13F, GLY160E, GLY160F, GLY164E, GLY164F, GLY179E, GLY179F, GLY223E, GLY223F, GLY225E, GLY225F, GLY52E, GLY52F, GLY61E, GLY61F, HIS136E, HIS136F, HIS170E, HIS170F, HIS183E, HIS183F, HIS55E, HIS55F, ILE118E, ILE118F, ILE168E, ILE168F, ILE177E, ILE177F, ILE180E, ILE180F, ILE186E, ILE186F, ILE27E, ILE27F, ILE47E, ILE47F, LEU106E, LEU106F, LEU108E, LEU108F, LEU116E, LEU116F, LEU132E, LEU132F, LEU142E, LEU142F, LEU152E, LEU152F, LEU154E, LEU154F, LEU178E, LEU178F, LEU198E, LEU198F, LEU204E, LEU204F, LEU213E, LEU213F, LEU215E, LEU215F, LEU218E, LEU218F, LEU38F, LEU46E, LEU46F, LEU50E, LEU50F, LEU51E, LEU51F, LEU70E, LEU70F, LEU9E, LEU9F, LYS102E, LYS102F, LYS107E, LYS107F, LYS175E, LYS175F, LYS207E, LYS207F, MET140E, MET140F, MET63E, MET63F, MET94E, MET94F, PHE15E, PHE15F, PHE169E, PHE169F, PHE194F, PHE220E, PHE220F, PHE62E, PHE62F, PHE68E, PHE68F, PHE84E, PHE84F, PHE95E, PHE95F, PRO138E, PRO138F, PRO181E, PRO181F, PRO202E, PRO202F, PRO214E, PRO214F, PRO58E, PRO58F, PRO65E, PRO65F, SER117E, SER117F, SER144E, SER144F, SER167E, SER167F, SER16E, SER16F, SER17E, SER17F, SER59E, SER59F, SER96F, THR10E, THR10F, THR121E, THR121F, THR125E, THR125F, THR135E, THR135F, THR145E, THR145F, THR29E, THR29F, THR76E, THR76F, TRP153E, TRP153F, TRP165E, TRP165F, TRP189E, TRP189F, TRP209E, TRP209F, TRP224E, TRP224F, TRP66E, TRP66F, TYR103E, TYR103F, TYR143E, TYR143F, TYR199E, TYR199F, TYR24E, TYR24F, VAL120E, VAL120F, VAL130E, VAL130F, VAL131E, VAL131F, VAL146E, VAL146F, VAL149E, VAL149F, VAL161E, VAL161F, VAL163E, VAL163F, VAL166E, VAL166F, VAL184E, VAL184F, VAL187E, VAL187F, VAL195E, VAL195F, VAL219E, VAL219F, VAL226E, VAL226F, VAL23E, VAL23F, VAL33E, VAL33F, VAL60E, VAL60F, VAL69E, VAL69F, VAL71E, VAL71F
• E-G: ALA129E, ARG124E, ARG126E, ARG134E, ARG227G, ASP123E, ASP182E, ASP217G, GLN64E, GLU216G, GLU221G, GLU44E, GLU45E, GLU98G, GLY127E, GLY128E, GLY223G, GLY225G, GLY61E, GLY97G, HIS183E, LEU132E, LEU215G, LEU218G, MET63E, PHE220G, PHE62E, PRO181E, PRO214G, PRO65E, SER96G, THR125E, TRP224G, VAL130E, VAL131E, VAL184E, VAL219G, VAL226G
• E-H: ALA129E, ALA129H, ASP182E, GLU44E, GLU44H, GLY179E, GLY179H, HIS183E, HIS183H, PRO181E, PRO181H
• F-G: ALA205F, ALA205G, ARG210F, ARG210G, ARG212F, ARG212G, ARG227F, ARG227G, ARG99F, ARG99G, ASP217F, ASP217G, GLN211F, GLN211G, GLU201F, GLU201G, GLU216F, GLU216G, LEU213F, LEU213G, LEU215F, LEU215G, LEU218F, LEU218G, PHE95F, PHE95G, PRO214F, PRO214G, TRP209F, TRP209G
• F-H: ALA129H, ALA48H, ARG124H, ARG126H, ARG134H, ARG227F, ARG99F, ASP123H, ASP182H, ASP217F, GLN211F, GLN64H, GLU216F, GLU221F, GLU44H, GLU45H, GLU98F, GLY127H, GLY128H, GLY225F, GLY61H, GLY97F, HIS183H, LEU213F, LEU215F, LEU218F, MET63H, MET94F, PHE220F, PHE62H, PHE95F, PRO181H, PRO214F, PRO65H, SER96F, THR125H, TRP224F, VAL130H, VAL131H, VAL184H, VAL219F, VAL226F
• G-H: ALA11G, ALA11H, ALA129G, ALA129H, ALA12G, ALA12H, ALA148G, ALA148H, ALA14G, ALA14H, ALA155G, ALA155H, ALA156G, ALA156H, ALA158G, ALA158H, ALA188G, ALA188H, ALA205G, ALA205H, ALA206G, ALA206H, ALA21G, ALA21H, ALA22G, ALA22H, ALA26G, ALA26H, ALA48G, ALA48H, ALA53G, ALA53H, ALA54G, ALA54H, ALA57G, ALA57H, ALA83G, ALA87G, ALA87H, ALA91G, ALA91H, ALA92G, ALA92H, ARG124G, ARG124H, ARG126G, ARG126H, ARG134G, ARG134H, ARG157G, ARG157H, ARG197G, ARG197H, ARG20G, ARG20H, ARG210G, ARG210H, ARG212G, ARG212H, ARG227G, ARG227H, ARG25G, ARG25H, ARG30G, ARG30H, ARG31G, ARG31H, ARG34G, ARG34H, ARG49G, ARG49H, ARG72G, ARG72H, ARG77G, ARG77H, ARG86G, ARG86H, ARG99G, ARG99H, ASN137G, ASN137H, ASN151G, ASN151H, ASN67G, ASN67H, ASN88G, ASN88H, ASP123G, ASP123H, ASP141G, ASP141H, ASP18G, ASP18H, ASP196G, ASP196H, ASP217G, ASP217H, ASP32G, ASP32H, ASP35G, ASP35H, ASP74G, ASP74H, ASP89G, ASP89H, CYS119G, CYS119H, CYS122G, CYS122H, CYS147G, CYS147H, GLN139G, GLN139H, GLN150G, GLN150H, GLN200G, GLN200H, GLN211G, GLN211H, GLN56G, GLN56H, GLN64G, GLN64H, GLN73G, GLN73H, GLU159G, GLU159H, GLU171G, GLU171H, GLU173G, GLU185G, GLU185H, GLU19G, GLU19H, GLU201G, GLU201H, GLU203G, GLU203H, GLU216G, GLU216H, GLU221G, GLU221H, GLU222G, GLU222H, GLU28G, GLU28H, GLU36G, GLU36H, GLU44G, GLU44H, GLU45G, GLU45H, GLU75G, GLU90G, GLU90H, GLU93G, GLU93H, GLY127G, GLY127H, GLY128G, GLY128H, GLY133G, GLY133H, GLY13G, GLY13H, GLY160G, GLY160H, GLY164G, GLY164H, GLY179G, GLY179H, GLY223G, GLY223H, GLY225G, GLY225H, GLY52G, GLY52H, GLY61G, GLY61H, HIS136G, HIS136H, HIS170G, HIS170H, HIS183G, HIS183H, HIS55G, HIS55H, ILE118G, ILE118H, ILE168G, ILE168H, ILE177G, ILE177H, ILE180G, ILE180H, ILE186G, ILE186H, ILE27G, ILE27H, ILE47G, ILE47H, LEU106G, LEU106H, LEU108G, LEU108H, LEU116G, LEU116H, LEU132G, LEU132H, LEU142G, LEU142H, LEU152G, LEU152H, LEU154G, LEU154H, LEU178G, LEU178H, LEU198G, LEU198H, LEU204G, LEU204H, LEU213G, LEU213H, LEU215G, LEU215H, LEU218G, LEU218H, LEU38G, LEU38H, LEU46G, LEU46H, LEU50G, LEU50H, LEU51G, LEU51H, LEU70G, LEU70H, LEU9G, LEU9H, LYS102G, LYS102H, LYS107G, LYS107H, LYS175G, LYS175H, LYS207G, MET140G, MET140H, MET63G, MET63H, MET94G, MET94H, PHE15G, PHE15H, PHE169G, PHE169H, PHE194G, PHE194H, PHE220G, PHE220H, PHE62G, PHE62H, PHE68G, PHE68H, PHE84G, PHE84H, PHE95G, PHE95H, PRO138G, PRO138H, PRO181G, PRO181H, PRO202G, PRO202H, PRO214G, PRO214H, PRO58G, PRO58H, PRO65G, PRO65H, SER117G, SER117H, SER144G, SER144H, SER167G, SER167H, SER16G, SER16H, SER17H, SER59G, SER59H, SER96G, SER96H, THR10G, THR10H, THR121G, THR121H, THR125G, THR125H, THR135G, THR135H, THR145G, THR145H, THR29G, THR29H, THR76G, THR76H, TRP153G, TRP153H, TRP165G, TRP165H, TRP189G, TRP189H, TRP209G, TRP209H, TRP224G, TRP224H, TRP66G, TRP66H, TYR103G, TYR103H, TYR143G, TYR143H, TYR199G, TYR199H, TYR24G, TYR24H, VAL120G, VAL120H, VAL130G, VAL130H, VAL131G, VAL131H, VAL146G, VAL146H, VAL149G, VAL149H, VAL161G, VAL161H, VAL163G, VAL163H, VAL166G, VAL166H, VAL184G, VAL184H, VAL187G, VAL187H, VAL195G, VAL195H, VAL219G, VAL219H, VAL226G, VAL226H, VAL23G, VAL23H, VAL33G, VAL60G, VAL60H, VAL69G, VAL69H, VAL71G, VAL71H