2ISA

crystal structure of vibrio salmonicida catalase

• Total interactions analyzed: 28
• Total true interactions: 18
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 326
  • Norm. En. per Res.: -6.5943
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-308.7935	-494.0847	-1346.86	-2149.7382	326	48	17	47703	42	195	176
A-C	-274.6693	-3.5336	-1174.0	-1452.2029	317	35	25	43746	2	100	81
A-D	-155.0294	-3.8925	-504.534	-663.4559	195	28	19	18763	6	55	58
A-H	0.0	0.0	-0.0031	-0.0031	2	0	0	3	0	2	2
B-C	-143.9862	-0.9983	-510.385	-655.3695	198	30	20	18741	6	54	60
B-D	-270.647	-6.7436	-1169.47	-1446.8606	319	39	25	43755	2	98	79
B-H	-13.0966	-12.8513	-84.7254	-110.6732	85	6	0	3525	0	35	35
C-D	-310.694	-473.6812	-1338.29	-2122.6651	325	53	17	47435	42	195	176
C-G	0.0	45.5918	-39.0711	6.5207	25	0	0	1623	1	9	12
D-F	0.0	0.0	-2.1271	-2.1271	16	0	0	212	0	4	1
D-G	0.0	0.0	-0.0366	-0.0366	2	0	0	12	0	0	1
D-H	-3.0615	-24.1907	-64.9725	-92.2247	76	1	1	3456	1	34	26
E-F	-297.7097	-493.9133	-1355.89	-2147.5131	329	52	17	47627	44	197	177
E-G	-283.8302	-3.8894	-1165.21	-1452.9296	314	42	24	43604	2	99	82
E-H	-165.7681	-4.879	-515.086	-685.7331	196	33	19	18854	6	56	59
F-G	-164.6835	-4.0846	-513.691	-682.4591	196	28	19	18798	6	56	59
F-H	-254.9436	-5.8793	-1166.7	-1427.523	314	42	25	43719	2	99	81
G-H	-319.2887	-483.0247	-1327.14	-2129.4534	329	50	17	47427	43	193	176

Interface residues

• A-B: ALA101A, ALA101B, ALA102A, ALA102B, ALA104A, ALA104B, ALA146A, ALA146B, ALA158A, ALA158B, ALA15A, ALA15B, ALA227A, ALA227B, ALA229A, ALA229B, ALA23A, ALA23B, ALA268A, ALA268B, ALA269A, ALA269B, ALA306A, ALA306B, ALA336A, ALA336B, ALA340A, ALA340B, ALA406A, ALA406B, ALA407A, ALA407B, ALA408A, ALA408B, ALA41A, ALA41B, ALA55A, ALA55B, ALA96A, ALA96B, ARG106A, ARG106B, ARG135A, ARG135B, ARG149A, ARG149B, ARG152A, ARG152B, ARG156A, ARG156B, ARG237A, ARG237B, ARG242A, ARG242B, ARG26A, ARG26B, ARG299A, ARG299B, ARG333A, ARG333B, ARG342A, ARG342B, ARG344A, ARG344B, ARG413A, ARG413B, ARG45A, ARG45B, ARG51A, ARG51B, ARG52A, ARG52B, ARG91A, ARG91B, ARG99A, ARG99B, ASN144A, ASN144B, ASN154A, ASN154B, ASN17A, ASN17B, ASN19A, ASN19B, ASN235A, ASN235B, ASN274A, ASN274B, ASN300A, ASN300B, ASN303A, ASN303B, ASN402A, ASN402B, ASP103A, ASP103B, ASP136A, ASP136B, ASP142A, ASP142B, ASP150A, ASP150B, ASP226A, ASP226B, ASP236A, ASP236B, ASP243A, ASP243B, ASP246A, ASP246B, ASP249A, ASP249B, ASP277A, ASP277B, ASP327A, ASP327B, ASP339A, ASP339B, ASP33A, ASP33B, ASP404A, ASP404B, ASP411A, ASP411B, ASP415A, ASP415B, ASP44A, ASP44B, GLN18A, GLN18B, GLN21A, GLN21B, GLN241A, GLN241B, GLN29A, GLN29B, GLN302A, GLN302B, GLN32A, GLN32B, GLN331A, GLN331B, GLN341A, GLN341B, GLU105A, GLU105B, GLU170A, GLU170B, GLU231A, GLU231B, GLU238A, GLU238B, GLU307A, GLU307B, GLU309A, GLU309B, GLU38A, GLU38B, GLU414A, GLU414B, GLU46A, GLU46B, GLU50A, GLU50B, GLU98A, GLU98B, GLY100A, GLY100B, GLY230A, GLY230B, GLY234A, GLY234B, GLY24A, GLY24B, GLY27A, GLY27B, GLY332A, GLY332B, GLY338A, GLY338B, GLY405A, GLY405B, GLY57A, GLY57B, GLY59A, GLY59B, GLY97A, GLY97B, HIS145A, HIS145B, HIS16A, HIS16B, HIS240A, HIS240B, HIS409A, HIS409B, HIS412A, HIS412B, HIS42A, HIS42B, ILE248A, ILE248B, ILE48A, ILE48B, LEU138A, LEU138B, LEU143A, LEU143B, LEU168A, LEU168B, LEU232A, LEU232B, LEU244A, LEU245A, LEU245B, LEU30A, LEU30B, LEU31A, LEU31B, LEU330A, LEU330B, LEU334A, LEU334B, LEU37A, LEU37B, LEU401A, LEU401B, LEU403A, LEU403B, LEU40A, LEU40B, LEU6A, LEU6B, LYS139A, LYS139B, LYS148A, LYS148B, LYS25A, LYS25B, LYS280A, LYS280B, LYS328A, LYS328B, LYS39A, LYS39B, LYS56A, LYS56B, MET155A, MET155B, MET329A, MET329B, PHE140A, PHE140B, PHE164A, PHE164B, PHE276A, PHE276B, PHE305A, PHE305B, PHE324A, PHE324B, PHE335A, PHE335B, PHE36A, PHE36B, PHE43A, PHE43B, PRO137A, PRO137B, PRO141A, PRO141B, PRO151A, PRO151B, PRO272B, PRO275A, PRO275B, PRO28A, PRO28B, PRO301A, PRO301B, PRO326A, PRO326B, PRO49A, PRO49B, SER157A, SER157B, SER239A, SER239B, SER325A, SER325B, SER58A, SER58B, THR153A, THR153B, THR22A, THR22B, THR270B, TRP210A, TRP210B, TRP35A, TRP35B, TRP410A, TRP410B, TYR273A, TYR273B, TYR304A, TYR304B, TYR337A, TYR337B, TYR343A, TYR343B, VAL147A, VAL14A, VAL14B, VAL20A, VAL20B, VAL233A, VAL233B, VAL271A, VAL271B, VAL308A, VAL308B, VAL34A, VAL34B, VAL47A, VAL47B
• A-C: ALA10A, ALA10C, ALA15A, ALA15C, ALA23A, ALA23C, ALA306A, ALA306C, ALA316A, ALA316C, ALA336A, ALA336C, ALA340A, ALA340C, ALA356A, ALA356C, ALA369A, ALA369C, ALA391A, ALA391C, ALA407A, ALA407C, ALA408A, ALA408C, ALA41A, ALA41C, ALA9A, ALA9C, ARG208A, ARG208C, ARG333A, ARG333C, ARG342A, ARG342C, ARG344A, ARG344C, ARG358A, ARG358C, ARG366A, ARG366C, ARG371A, ARG371C, ARG45A, ARG45C, ARG99A, ARG99C, ASN121A, ASN121C, ASN17A, ASN17C, ASN19A, ASN19C, ASN206A, ASN206C, ASN300C, ASN303A, ASN303C, ASN314A, ASN314C, ASN317A, ASN317C, ASN348A, ASN348C, ASN355A, ASN355C, ASN375A, ASN375C, ASN385A, ASN385C, ASP123A, ASP123C, ASP327A, ASP327C, ASP339A, ASP339C, ASP33A, ASP33C, ASP367A, ASP367C, ASP373A, ASP373C, ASP386A, ASP386C, ASP395A, ASP395C, ASP44A, ASP44C, CYS12A, CYS12C, CYS359A, CYS359C, GLN18A, GLN18C, GLN21A, GLN21C, GLN302A, GLN302C, GLN310A, GLN310C, GLN32A, GLN32C, GLN331A, GLN331C, GLN350A, GLN350C, GLN387A, GLN387C, GLN389A, GLN389C, GLN393A, GLN393C, GLU118A, GLU118C, GLU119A, GLU119C, GLU307A, GLU307C, GLU309A, GLU309C, GLU383A, GLU383C, GLU38A, GLU38C, GLU392A, GLU392C, GLU398A, GLU398C, GLU46A, GLU46C, GLY11A, GLY11C, GLY120A, GLY120C, GLY24A, GLY24C, GLY27A, GLY27C, GLY321C, GLY332A, GLY332C, GLY338A, GLY338C, GLY346A, GLY346C, GLY368A, GLY368C, GLY374A, GLY374C, GLY377A, GLY377C, GLY381A, GLY381C, GLY388A, GLY388C, GLY405A, GLY405C, HIS16A, HIS16C, HIS349A, HIS349C, HIS351A, HIS351C, HIS362A, HIS362C, HIS365A, HIS365C, HIS42A, HIS42C, ILE322A, ILE322C, ILE352A, ILE352C, ILE48A, ILE48C, LEU30A, LEU30C, LEU31A, LEU31C, LEU330A, LEU330C, LEU334A, LEU334C, LEU345A, LEU345C, LEU37A, LEU37C, LEU380C, LEU401A, LEU401C, LEU403A, LEU403C, LEU40A, LEU40C, LEU6A, LEU6C, LYS114A, LYS114C, LYS328A, LYS328C, LYS39A, LYS39C, LYS4A, LYS4C, LYS5A, LYS5C, LYS75A, LYS75C, LYS77A, MET370A, MET370C, PHE115A, PHE115C, PHE305A, PHE305C, PHE324A, PHE324C, PHE335A, PHE335C, PHE36A, PHE36C, PHE376A, PHE376C, PHE396A, PHE396C, PHE43A, PHE43C, PRO137A, PRO137C, PRO13A, PRO13C, PRO28A, PRO28C, PRO301A, PRO301C, PRO315A, PRO315C, PRO320A, PRO320C, PRO326A, PRO326C, PRO353A, PRO353C, PRO357A, PRO357C, PRO360A, PRO360C, PRO384A, PRO384C, PRO394A, PRO394C, PRO399A, PRO399C, PRO400A, PRO400C, PRO49A, PRO49C, SER200C, SER323A, SER323C, SER325A, SER325C, SER363A, SER363C, SER378A, SER378C, SER397A, SER397C, SER3A, SER3C, THR117A, THR117C, THR22A, THR22C, THR379A, THR379C, THR7A, THR7C, THR8A, THR8C, TRP122A, TRP122C, TRP210A, TRP210C, TRP35A, TRP35C, TRP390A, TRP390C, TYR116A, TYR116C, TYR304A, TYR304C, TYR337A, TYR337C, TYR343A, TYR343C, TYR364A, TYR364C, TYR382A, TYR382C, VAL14A, VAL14C, VAL318A, VAL318C, VAL319A, VAL319C, VAL347A, VAL347C, VAL34A, VAL34C, VAL354A, VAL354C, VAL361A, VAL361C, VAL372A, VAL372C, VAL47A, VAL47C
• A-D: ALA146A, ALA146D, ALA23A, ALA23D, ALA369A, ALA369D, ALA406A, ALA406D, ALA407A, ALA407D, ALA408A, ALA408D, ALA41A, ALA41D, ARG149A, ARG149D, ARG152A, ARG152D, ARG208A, ARG208D, ARG342A, ARG342D, ARG366A, ARG366D, ARG413A, ARG413D, ARG455A, ARG455D, ARG45A, ARG45D, ARG52A, ARG52D, ASN144A, ASN144D, ASN160A, ASN160D, ASN161A, ASN161D, ASN348A, ASN375A, ASN375D, ASN385A, ASN385D, ASN402A, ASN402D, ASP142A, ASP142D, ASP150A, ASP150D, ASP163A, ASP163D, ASP339A, ASP339D, ASP33A, ASP33D, ASP367A, ASP367D, ASP386A, ASP386D, ASP404A, ASP404D, GLN21A, GLN21D, GLN29A, GLN29D, GLN32A, GLN32D, GLN387A, GLN387D, GLU170A, GLU170D, GLU383A, GLU383D, GLU392A, GLU392D, GLU398A, GLU398D, GLU451A, GLU451D, GLY24A, GLY24D, GLY27A, GLY27D, GLY346A, GLY346D, GLY368A, GLY368D, GLY377A, GLY377D, GLY381A, GLY381D, GLY388A, GLY388D, GLY405A, GLY405D, HIS145A, HIS145D, HIS365A, HIS365D, HIS409A, HIS409D, ILE452A, ILE452D, LEU134A, LEU134D, LEU138A, LEU138D, LEU143A, LEU143D, LEU168A, LEU168D, LEU30A, LEU30D, LEU31A, LEU31D, LEU37A, LEU37D, LEU380A, LEU380D, LEU401A, LEU401D, LEU403A, LEU403D, LEU40A, LEU40D, LYS139A, LYS139D, LYS148A, LYS148D, LYS159A, LYS159D, PHE140A, PHE140D, PHE164A, PHE164D, PHE335A, PHE335D, PHE36A, PHE36D, PHE376A, PHE376D, PRO141A, PRO141D, PRO151A, PRO151D, PRO169A, PRO169D, PRO28A, PRO28D, PRO384A, PRO384D, PRO399A, PRO399D, PRO400A, PRO400D, PRO449A, PRO449D, PRO49A, PRO49D, SER157A, SER157D, SER167A, SER167D, SER378A, SER378D, SER397A, SER397D, THR153A, THR153D, THR166A, THR166D, THR22A, THR22D, THR379A, THR379D, TRP162A, TRP162D, TRP165A, TRP165D, TRP390A, TRP390D, TRP410A, TRP410D, TYR343A, TYR343D, TYR364A, TYR364D, TYR382A, TYR382D, VAL147A, VAL147D, VAL20A, VAL20D, VAL347A, VAL347D
• A-H: ARG152A, HIS68H
• B-C: ALA146B, ALA146C, ALA158B, ALA158C, ALA23B, ALA23C, ALA369B, ALA369C, ALA406B, ALA406C, ALA407B, ALA407C, ALA408B, ALA408C, ALA41B, ALA41C, ARG149B, ARG149C, ARG152B, ARG152C, ARG208B, ARG208C, ARG342B, ARG342C, ARG366B, ARG366C, ARG413B, ARG413C, ARG455B, ARG455C, ARG45B, ARG45C, ARG52B, ARG52C, ASN144B, ASN144C, ASN160B, ASN160C, ASN161B, ASN161C, ASN375B, ASN375C, ASN385B, ASN385C, ASN402B, ASN402C, ASP142B, ASP142C, ASP150B, ASP150C, ASP163B, ASP163C, ASP339B, ASP339C, ASP33B, ASP33C, ASP367B, ASP367C, ASP386B, ASP386C, ASP404B, ASP404C, GLN21B, GLN21C, GLN29B, GLN29C, GLN32B, GLN32C, GLN387B, GLN387C, GLU170B, GLU170C, GLU383B, GLU383C, GLU392B, GLU392C, GLU398B, GLU398C, GLU451B, GLU451C, GLY24B, GLY24C, GLY27B, GLY27C, GLY346B, GLY346C, GLY368B, GLY368C, GLY377B, GLY377C, GLY381B, GLY381C, GLY388B, GLY388C, GLY405B, GLY405C, HIS145B, HIS145C, HIS365B, HIS365C, HIS409B, HIS409C, HIS412C, ILE452B, ILE452C, LEU134B, LEU134C, LEU138B, LEU138C, LEU143B, LEU143C, LEU168B, LEU168C, LEU30B, LEU30C, LEU31B, LEU31C, LEU37B, LEU37C, LEU380B, LEU380C, LEU401B, LEU401C, LEU403B, LEU403C, LEU40B, LEU40C, LYS139B, LYS139C, LYS148B, LYS148C, LYS159B, LYS159C, PHE140B, PHE140C, PHE164B, PHE164C, PHE324B, PHE335B, PHE335C, PHE36B, PHE36C, PHE376B, PHE376C, PRO141B, PRO141C, PRO151B, PRO151C, PRO169B, PRO169C, PRO28B, PRO28C, PRO384B, PRO384C, PRO399B, PRO399C, PRO400B, PRO400C, PRO449B, PRO449C, PRO49B, PRO49C, SER157B, SER157C, SER167B, SER167C, SER378B, SER378C, SER397B, SER397C, THR153B, THR153C, THR166B, THR166C, THR22B, THR22C, THR379B, THR379C, TRP162B, TRP162C, TRP165B, TRP165C, TRP390B, TRP390C, TRP410B, TRP410C, TYR343B, TYR343C, TYR364B, TYR364C, TYR382B, TYR382C, VAL147B, VAL147C, VAL20B, VAL20C, VAL347B, VAL347C
• B-D: ALA10B, ALA10D, ALA15B, ALA15D, ALA23B, ALA23D, ALA306B, ALA306D, ALA312B, ALA312D, ALA316B, ALA316D, ALA336B, ALA336D, ALA340B, ALA340D, ALA356B, ALA356D, ALA369B, ALA369D, ALA391B, ALA391D, ALA406D, ALA407B, ALA407D, ALA408D, ALA41B, ALA41D, ALA9B, ALA9D, ARG208B, ARG208D, ARG333B, ARG333D, ARG342B, ARG342D, ARG344B, ARG344D, ARG358B, ARG358D, ARG366B, ARG366D, ARG371B, ARG371D, ARG45B, ARG45D, ARG99B, ARG99D, ASN121B, ASN121D, ASN17B, ASN17D, ASN19B, ASN19D, ASN206B, ASN206D, ASN303B, ASN303D, ASN314B, ASN314D, ASN317B, ASN317D, ASN348B, ASN348D, ASN355B, ASN355D, ASN375B, ASN375D, ASN385B, ASN385D, ASP123B, ASP123D, ASP327B, ASP327D, ASP339B, ASP339D, ASP33B, ASP33D, ASP367B, ASP367D, ASP373B, ASP373D, ASP386B, ASP386D, ASP395B, ASP395D, ASP404B, ASP404D, ASP44B, ASP44D, CYS12B, CYS12D, CYS359B, CYS359D, GLN18B, GLN18D, GLN21B, GLN21D, GLN302B, GLN302D, GLN310B, GLN310D, GLN32B, GLN32D, GLN331B, GLN331D, GLN350B, GLN350D, GLN387B, GLN387D, GLN389B, GLN389D, GLN393B, GLN393D, GLU118B, GLU118D, GLU119B, GLU119D, GLU307B, GLU307D, GLU309B, GLU309D, GLU383B, GLU383D, GLU38B, GLU38D, GLU392B, GLU392D, GLU398B, GLU398D, GLU46B, GLU46D, GLY11B, GLY11D, GLY120B, GLY120D, GLY24B, GLY24D, GLY27B, GLY27D, GLY332B, GLY332D, GLY338B, GLY338D, GLY346B, GLY346D, GLY368B, GLY368D, GLY374B, GLY374D, GLY377B, GLY377D, GLY381B, GLY381D, GLY388B, GLY388D, GLY405B, GLY405D, HIS16B, HIS16D, HIS349B, HIS349D, HIS351B, HIS351D, HIS362B, HIS362D, HIS365B, HIS365D, HIS42B, HIS42D, ILE322B, ILE352B, ILE352D, ILE48B, ILE48D, LEU30B, LEU30D, LEU31B, LEU31D, LEU330B, LEU330D, LEU334B, LEU334D, LEU345B, LEU345D, LEU37B, LEU37D, LEU380B, LEU380D, LEU401B, LEU401D, LEU403B, LEU403D, LEU40B, LEU40D, LEU6B, LEU6D, LYS114B, LYS114D, LYS328B, LYS328D, LYS39B, LYS39D, LYS4B, LYS4D, LYS5B, LYS5D, LYS75B, LYS75D, LYS77B, MET370B, MET370D, PHE115B, PHE115D, PHE305B, PHE305D, PHE324B, PHE324D, PHE335B, PHE335D, PHE36B, PHE36D, PHE376B, PHE376D, PHE396B, PHE396D, PHE43B, PHE43D, PRO137B, PRO137D, PRO13B, PRO13D, PRO28B, PRO28D, PRO301B, PRO301D, PRO315B, PRO315D, PRO320B, PRO320D, PRO326B, PRO326D, PRO353B, PRO353D, PRO357B, PRO357D, PRO360B, PRO360D, PRO384B, PRO384D, PRO394B, PRO394D, PRO399B, PRO399D, PRO400B, PRO400D, PRO49B, PRO49D, SER200B, SER323B, SER323D, SER325B, SER325D, SER363B, SER363D, SER378B, SER378D, SER397B, SER397D, SER3B, SER3D, THR117B, THR117D, THR22B, THR22D, THR379B, THR379D, THR7B, THR7D, THR8B, THR8D, TRP122B, TRP122D, TRP210B, TRP210D, TRP35B, TRP35D, TRP390B, TRP390D, TYR116B, TYR116D, TYR304B, TYR304D, TYR337B, TYR337D, TYR343B, TYR343D, TYR364B, TYR364D, TYR382B, TYR382D, VAL14B, VAL14D, VAL318B, VAL318D, VAL319B, VAL319D, VAL347B, VAL347D, VAL34B, VAL34D, VAL354B, VAL354D, VAL361B, VAL361D, VAL372B, VAL372D, VAL47B, VAL47D
• B-H: ALA356B, ALA76H, ARG189H, ARG299B, ARG358B, ARG366B, ARG371B, ASN250H, ASN298H, ASN300B, ASN303B, ASN375B, ASP249H, ASP252H, ASP373B, ASP69H, ASP81B, ASP81H, ASP87B, CYS359B, GLN218H, GLN219H, GLN251B, GLN251H, GLN302B, GLN387B, GLN389B, GLU118B, GLU118H, GLU119B, GLU119H, GLU291H, GLU294H, GLU296H, GLU307B, GLU432H, GLY220H, GLY374B, GLY377B, GLY388B, GLY83B, HIS190H, HIS351B, HIS362B, HIS68H, ILE78H, ILE82B, ILE82H, LEU380B, LYS222H, LYS255H, LYS259H, LYS4B, LYS5B, LYS75H, LYS77B, LYS77H, LYS84H, PHE253H, PHE376B, PHE79H, PRO254H, PRO288H, PRO301B, PRO353B, PRO357B, PRO360B, SER204H, SER217H, SER247H, SER363B, SER378B, SER3B, SER80H, THR257H, THR379B, THR430H, THR67H, THR71H, TRP390B, TYR116B, TYR61B, VAL216H, VAL361B, VAL372B
• C-D: ALA101C, ALA101D, ALA102C, ALA102D, ALA104C, ALA104D, ALA158C, ALA158D, ALA15C, ALA15D, ALA227C, ALA227D, ALA229C, ALA229D, ALA23C, ALA23D, ALA268C, ALA268D, ALA269C, ALA269D, ALA306C, ALA306D, ALA336C, ALA336D, ALA340C, ALA340D, ALA406C, ALA406D, ALA407C, ALA407D, ALA408C, ALA408D, ALA41C, ALA41D, ALA55C, ALA55D, ALA96C, ALA96D, ARG106C, ARG106D, ARG135C, ARG135D, ARG149C, ARG149D, ARG152C, ARG152D, ARG156C, ARG156D, ARG237C, ARG237D, ARG242C, ARG242D, ARG26C, ARG26D, ARG299C, ARG299D, ARG333C, ARG333D, ARG342C, ARG342D, ARG344C, ARG344D, ARG413C, ARG413D, ARG45C, ARG45D, ARG51C, ARG51D, ARG52C, ARG52D, ARG91C, ARG91D, ARG99C, ARG99D, ASN144C, ASN144D, ASN154C, ASN154D, ASN17C, ASN17D, ASN19C, ASN19D, ASN235C, ASN235D, ASN274C, ASN274D, ASN300C, ASN300D, ASN303C, ASN303D, ASN402C, ASN402D, ASP103C, ASP103D, ASP136C, ASP136D, ASP142C, ASP142D, ASP150C, ASP150D, ASP226C, ASP226D, ASP236C, ASP236D, ASP243C, ASP243D, ASP246C, ASP246D, ASP249C, ASP249D, ASP277C, ASP277D, ASP327C, ASP327D, ASP339C, ASP339D, ASP33C, ASP33D, ASP404C, ASP404D, ASP411C, ASP411D, ASP415C, ASP415D, ASP44C, ASP44D, GLN18C, GLN18D, GLN21C, GLN21D, GLN241C, GLN241D, GLN29C, GLN29D, GLN302C, GLN302D, GLN32C, GLN32D, GLN331C, GLN331D, GLN341C, GLN341D, GLU105C, GLU105D, GLU170C, GLU170D, GLU231C, GLU231D, GLU238C, GLU238D, GLU307C, GLU307D, GLU309C, GLU309D, GLU38C, GLU38D, GLU414C, GLU414D, GLU46C, GLU46D, GLU50C, GLU50D, GLU98C, GLU98D, GLY100C, GLY100D, GLY230C, GLY230D, GLY234C, GLY234D, GLY24C, GLY24D, GLY27C, GLY27D, GLY332C, GLY332D, GLY338C, GLY338D, GLY405C, GLY405D, GLY57C, GLY57D, GLY59C, GLY59D, GLY97C, GLY97D, HIS145C, HIS145D, HIS16C, HIS16D, HIS240C, HIS240D, HIS409C, HIS409D, HIS412C, HIS412D, HIS42C, HIS42D, ILE248C, ILE248D, ILE48C, ILE48D, LEU138C, LEU138D, LEU143C, LEU143D, LEU168C, LEU168D, LEU232C, LEU232D, LEU244D, LEU245C, LEU245D, LEU30C, LEU30D, LEU31C, LEU31D, LEU330C, LEU330D, LEU334C, LEU334D, LEU37C, LEU37D, LEU401C, LEU401D, LEU403C, LEU403D, LEU40C, LEU40D, LEU6C, LEU6D, LYS139C, LYS139D, LYS148C, LYS148D, LYS25C, LYS25D, LYS280C, LYS280D, LYS328C, LYS328D, LYS39C, LYS39D, LYS56C, LYS56D, MET155C, MET155D, MET329C, MET329D, PHE140C, PHE140D, PHE164C, PHE164D, PHE276C, PHE276D, PHE305C, PHE305D, PHE324C, PHE324D, PHE335C, PHE335D, PHE36C, PHE36D, PHE43C, PHE43D, PRO137C, PRO137D, PRO141C, PRO141D, PRO151C, PRO151D, PRO272C, PRO272D, PRO275C, PRO275D, PRO28C, PRO28D, PRO301C, PRO301D, PRO326C, PRO326D, PRO49C, PRO49D, SER157C, SER157D, SER239C, SER239D, SER325C, SER325D, SER58C, SER58D, THR153C, THR153D, THR22C, THR22D, THR270C, THR270D, TRP210C, TRP210D, TRP35C, TRP35D, TRP410C, TRP410D, TYR273C, TYR273D, TYR304C, TYR304D, TYR337C, TYR337D, TYR343C, TYR343D, VAL14C, VAL14D, VAL20C, VAL20D, VAL233C, VAL233D, VAL271C, VAL271D, VAL308C, VAL308D, VAL34C, VAL34D, VAL47C, VAL47D
• C-G: ARG455C, ASN483C, ASN483G, ASP478C, ASP478G, GLN453C, GLU451C, GLU451G, GLU481C, GLU481G, GLY476G, ILE452C, ILE479C, ILE479G, LEU454C, LEU454G, LYS450C, LYS450G, PHE477C, PHE477G, PRO449C, PRO449G, SER480C, SER480G, TYR482C
• D-F: ASN250D, ASP249D, GLN251D, GLN302F, GLN387F, GLN389F, GLY377F, GLY388F, HIS362F, ILE82D, LYS77D, PHE376F, SER378F, SER3F, THR379F, TRP390F
• D-G: ARG152G, GLN302D
• D-H: ALA306D, ALA356D, ARG189H, ARG299D, ARG299H, ARG358D, ARG358H, ARG366D, ARG371D, ASN250D, ASN250H, ASN298D, ASN298H, ASN300H, ASN303D, ASN375D, ASP243H, ASP246H, ASP249D, ASP249H, ASP252D, ASP252H, ASP373D, ASP69H, ASP81H, ASP87D, ASP87H, CYS359D, CYS359H, GLN251D, GLN251H, GLN302D, GLN302H, GLN387D, GLN389D, GLU118D, GLU118H, GLU307D, GLY374D, GLY377D, GLY83H, HIS351D, HIS362D, HIS68H, ILE248H, ILE82H, LEU380D, LYS4D, LYS4H, LYS5D, LYS77D, LYS77H, LYS84D, LYS84H, LYS85H, PHE253D, PHE253H, PHE376D, PRO353D, PRO357D, PRO360D, PRO360H, SER247D, SER247H, SER378D, SER3D, SER3H, SER80H, THR379D, THR65H, THR67H, THR71H, TRP390D, VAL361D, VAL372D, VAL66H
• E-F: ALA101E, ALA101F, ALA102E, ALA102F, ALA104E, ALA104F, ALA146E, ALA146F, ALA158E, ALA158F, ALA15E, ALA15F, ALA227E, ALA227F, ALA229E, ALA229F, ALA23E, ALA23F, ALA268E, ALA268F, ALA269E, ALA269F, ALA306E, ALA306F, ALA336E, ALA336F, ALA340E, ALA340F, ALA406E, ALA406F, ALA407E, ALA407F, ALA408E, ALA408F, ALA41E, ALA41F, ALA55E, ALA55F, ALA96E, ALA96F, ARG106E, ARG106F, ARG135E, ARG135F, ARG149E, ARG149F, ARG152E, ARG152F, ARG156E, ARG156F, ARG237E, ARG237F, ARG242E, ARG242F, ARG26E, ARG26F, ARG299E, ARG299F, ARG333E, ARG333F, ARG342E, ARG342F, ARG344E, ARG344F, ARG413E, ARG413F, ARG45E, ARG45F, ARG51E, ARG51F, ARG52E, ARG52F, ARG91E, ARG91F, ARG99E, ARG99F, ASN144E, ASN144F, ASN154E, ASN154F, ASN17E, ASN17F, ASN19E, ASN19F, ASN235E, ASN235F, ASN274E, ASN274F, ASN300E, ASN300F, ASN303E, ASN303F, ASN402E, ASN402F, ASP103E, ASP103F, ASP136E, ASP136F, ASP142E, ASP142F, ASP150E, ASP150F, ASP226E, ASP226F, ASP236E, ASP236F, ASP243E, ASP243F, ASP246E, ASP246F, ASP249E, ASP249F, ASP277E, ASP277F, ASP327E, ASP327F, ASP339E, ASP339F, ASP33E, ASP33F, ASP404E, ASP404F, ASP411E, ASP411F, ASP415E, ASP415F, ASP44E, ASP44F, GLN18E, GLN18F, GLN21E, GLN21F, GLN241E, GLN241F, GLN29E, GLN29F, GLN302E, GLN302F, GLN32E, GLN32F, GLN331E, GLN331F, GLN341E, GLN341F, GLU105E, GLU105F, GLU170E, GLU170F, GLU231E, GLU231F, GLU238E, GLU238F, GLU307E, GLU307F, GLU309E, GLU309F, GLU38E, GLU38F, GLU414E, GLU414F, GLU46E, GLU46F, GLU50E, GLU50F, GLU98E, GLU98F, GLY100E, GLY100F, GLY230E, GLY230F, GLY234E, GLY234F, GLY24E, GLY24F, GLY27E, GLY27F, GLY332E, GLY332F, GLY338E, GLY338F, GLY405E, GLY405F, GLY57E, GLY57F, GLY59E, GLY59F, GLY97E, GLY97F, HIS145E, HIS145F, HIS16E, HIS16F, HIS240E, HIS240F, HIS409E, HIS409F, HIS412E, HIS412F, HIS42E, HIS42F, ILE184E, ILE248E, ILE248F, ILE48E, ILE48F, LEU138E, LEU138F, LEU143E, LEU143F, LEU168E, LEU168F, LEU232E, LEU232F, LEU244E, LEU244F, LEU245E, LEU245F, LEU30E, LEU30F, LEU31E, LEU31F, LEU330E, LEU330F, LEU334E, LEU334F, LEU37E, LEU37F, LEU401E, LEU401F, LEU403E, LEU403F, LEU40E, LEU40F, LEU6E, LEU6F, LYS139E, LYS139F, LYS148E, LYS148F, LYS25E, LYS25F, LYS280E, LYS280F, LYS328E, LYS328F, LYS39E, LYS39F, LYS56E, LYS56F, MET155E, MET155F, MET329E, MET329F, PHE140E, PHE140F, PHE164E, PHE164F, PHE276E, PHE276F, PHE305E, PHE305F, PHE324E, PHE324F, PHE335E, PHE335F, PHE36E, PHE36F, PHE43E, PHE43F, PRO137E, PRO137F, PRO141E, PRO141F, PRO151E, PRO151F, PRO272E, PRO272F, PRO275E, PRO275F, PRO28E, PRO28F, PRO301E, PRO301F, PRO326E, PRO326F, PRO49E, PRO49F, SER157E, SER157F, SER239E, SER239F, SER325E, SER325F, SER58E, SER58F, THR153E, THR153F, THR22E, THR22F, THR270E, THR270F, TRP210E, TRP210F, TRP35E, TRP35F, TRP410E, TRP410F, TYR273E, TYR273F, TYR304E, TYR304F, TYR337E, TYR337F, TYR343E, TYR343F, VAL14E, VAL14F, VAL20E, VAL20F, VAL233E, VAL233F, VAL271E, VAL271F, VAL308E, VAL308F, VAL34E, VAL34F, VAL47E, VAL47F
• E-G: ALA10E, ALA10G, ALA15E, ALA15G, ALA23E, ALA23G, ALA306E, ALA306G, ALA316E, ALA316G, ALA336E, ALA336G, ALA340E, ALA340G, ALA356E, ALA356G, ALA369E, ALA369G, ALA391E, ALA391G, ALA407E, ALA407G, ALA41E, ALA41G, ALA9E, ALA9G, ARG208E, ARG208G, ARG333E, ARG333G, ARG342E, ARG342G, ARG344E, ARG344G, ARG358E, ARG358G, ARG366E, ARG366G, ARG371E, ARG371G, ARG45E, ARG45G, ARG99E, ARG99G, ASN121E, ASN121G, ASN17E, ASN17G, ASN19E, ASN19G, ASN206G, ASN300G, ASN303E, ASN303G, ASN314E, ASN314G, ASN317E, ASN317G, ASN348E, ASN348G, ASN355E, ASN355G, ASN375E, ASN375G, ASN385E, ASN385G, ASP123E, ASP123G, ASP327E, ASP327G, ASP339E, ASP339G, ASP33E, ASP33G, ASP367E, ASP367G, ASP373E, ASP373G, ASP386E, ASP386G, ASP395E, ASP395G, ASP404G, ASP44E, ASP44G, CYS12E, CYS12G, CYS359E, CYS359G, GLN18E, GLN18G, GLN21E, GLN21G, GLN302E, GLN302G, GLN310E, GLN310G, GLN32E, GLN32G, GLN331E, GLN331G, GLN350E, GLN350G, GLN387E, GLN387G, GLN389E, GLN389G, GLN393E, GLN393G, GLU118E, GLU118G, GLU119E, GLU119G, GLU307E, GLU307G, GLU309E, GLU309G, GLU383E, GLU383G, GLU38E, GLU38G, GLU392E, GLU392G, GLU398E, GLU398G, GLU46E, GLU46G, GLY11E, GLY11G, GLY120E, GLY120G, GLY24E, GLY24G, GLY27E, GLY27G, GLY332E, GLY332G, GLY338E, GLY338G, GLY346E, GLY346G, GLY368E, GLY368G, GLY374E, GLY374G, GLY377E, GLY377G, GLY381E, GLY381G, GLY388E, GLY388G, GLY405E, GLY405G, HIS16E, HIS16G, HIS349E, HIS349G, HIS351E, HIS351G, HIS362E, HIS362G, HIS365E, HIS365G, HIS42E, HIS42G, ILE322G, ILE352E, ILE352G, ILE48E, ILE48G, LEU30E, LEU30G, LEU31E, LEU31G, LEU330E, LEU330G, LEU334E, LEU334G, LEU345E, LEU345G, LEU37E, LEU37G, LEU380G, LEU401E, LEU401G, LEU403E, LEU403G, LEU40E, LEU40G, LEU6E, LEU6G, LYS114E, LYS114G, LYS328E, LYS328G, LYS39E, LYS39G, LYS4E, LYS4G, LYS5E, LYS5G, LYS75E, LYS75G, LYS77E, LYS77G, MET370E, MET370G, PHE115E, PHE115G, PHE305E, PHE305G, PHE324E, PHE324G, PHE335E, PHE335G, PHE36E, PHE36G, PHE376E, PHE376G, PHE396E, PHE396G, PHE43E, PHE43G, PRO137E, PRO137G, PRO13E, PRO13G, PRO28E, PRO28G, PRO301E, PRO301G, PRO315E, PRO315G, PRO320E, PRO320G, PRO326E, PRO326G, PRO353E, PRO353G, PRO357E, PRO357G, PRO360E, PRO360G, PRO384E, PRO384G, PRO394E, PRO394G, PRO399E, PRO399G, PRO400E, PRO400G, PRO49E, PRO49G, SER200E, SER323E, SER323G, SER325E, SER325G, SER363E, SER363G, SER378E, SER378G, SER397E, SER397G, SER3E, SER3G, THR117E, THR117G, THR22E, THR22G, THR379E, THR379G, THR7E, THR7G, THR8E, THR8G, TRP122E, TRP122G, TRP210E, TRP210G, TRP35E, TRP35G, TRP390E, TRP390G, TYR116E, TYR116G, TYR304E, TYR304G, TYR337E, TYR337G, TYR343E, TYR343G, TYR364E, TYR364G, TYR382E, TYR382G, VAL14E, VAL14G, VAL318E, VAL318G, VAL319E, VAL319G, VAL347E, VAL347G, VAL34E, VAL34G, VAL354E, VAL354G, VAL361E, VAL361G, VAL372E, VAL372G, VAL47E, VAL47G
• E-H: ALA146E, ALA146H, ALA158H, ALA23E, ALA23H, ALA369E, ALA369H, ALA406E, ALA406H, ALA407E, ALA407H, ALA408E, ALA408H, ALA41E, ALA41H, ARG149E, ARG149H, ARG152E, ARG152H, ARG208E, ARG208H, ARG342E, ARG342H, ARG366E, ARG366H, ARG413E, ARG413H, ARG455E, ARG455H, ARG45E, ARG45H, ARG52E, ARG52H, ASN144E, ASN144H, ASN160E, ASN160H, ASN161E, ASN161H, ASN348H, ASN375E, ASN375H, ASN385E, ASN385H, ASN402E, ASN402H, ASP142E, ASP142H, ASP150E, ASP150H, ASP163E, ASP163H, ASP339E, ASP339H, ASP33E, ASP33H, ASP367E, ASP367H, ASP386E, ASP386H, ASP404E, ASP404H, GLN21E, GLN21H, GLN29E, GLN29H, GLN32E, GLN32H, GLN387E, GLN387H, GLU170E, GLU170H, GLU383E, GLU383H, GLU392E, GLU392H, GLU398E, GLU398H, GLU451E, GLU451H, GLY24E, GLY24H, GLY27E, GLY27H, GLY346E, GLY346H, GLY368E, GLY368H, GLY377E, GLY377H, GLY381E, GLY381H, GLY388E, GLY388H, GLY405E, GLY405H, HIS145E, HIS145H, HIS365E, HIS365H, HIS409E, HIS409H, ILE452E, ILE452H, LEU134E, LEU134H, LEU138E, LEU138H, LEU143E, LEU143H, LEU168E, LEU168H, LEU30E, LEU30H, LEU31E, LEU31H, LEU37E, LEU37H, LEU380E, LEU380H, LEU401E, LEU401H, LEU403E, LEU403H, LEU40E, LEU40H, LYS139E, LYS139H, LYS148E, LYS148H, LYS159E, LYS159H, PHE140E, PHE140H, PHE164E, PHE164H, PHE335E, PHE335H, PHE36E, PHE36H, PHE376E, PHE376H, PRO141E, PRO141H, PRO151E, PRO151H, PRO169E, PRO169H, PRO28E, PRO28H, PRO384E, PRO384H, PRO399E, PRO399H, PRO400E, PRO400H, PRO449E, PRO449H, PRO49E, PRO49H, SER157E, SER157H, SER167E, SER167H, SER378E, SER378H, SER397E, SER397H, THR153E, THR153H, THR166E, THR166H, THR22E, THR22H, THR379E, THR379H, TRP162E, TRP162H, TRP165E, TRP165H, TRP390E, TRP390H, TRP410E, TRP410H, TYR343E, TYR343H, TYR364E, TYR364H, TYR382E, TYR382H, VAL147E, VAL147H, VAL20E, VAL20H, VAL347E, VAL347H
• F-G: ALA146F, ALA146G, ALA23F, ALA23G, ALA369F, ALA369G, ALA406F, ALA406G, ALA407F, ALA407G, ALA408F, ALA408G, ALA41F, ALA41G, ARG149F, ARG149G, ARG152F, ARG152G, ARG208F, ARG208G, ARG342F, ARG342G, ARG366F, ARG366G, ARG413F, ARG413G, ARG455F, ARG455G, ARG45F, ARG45G, ARG52F, ARG52G, ASN144F, ASN144G, ASN160F, ASN160G, ASN161F, ASN161G, ASN348G, ASN375F, ASN375G, ASN385F, ASN385G, ASN402F, ASN402G, ASP142F, ASP142G, ASP150F, ASP150G, ASP163F, ASP163G, ASP339F, ASP339G, ASP33F, ASP33G, ASP367F, ASP367G, ASP386F, ASP386G, ASP404F, ASP404G, GLN21F, GLN21G, GLN29F, GLN29G, GLN32F, GLN32G, GLN387F, GLN387G, GLU170F, GLU170G, GLU383F, GLU383G, GLU392F, GLU392G, GLU398F, GLU398G, GLU451F, GLU451G, GLY24F, GLY24G, GLY27F, GLY27G, GLY346F, GLY346G, GLY368F, GLY368G, GLY377F, GLY377G, GLY381F, GLY381G, GLY388F, GLY388G, GLY405F, GLY405G, HIS145F, HIS145G, HIS365F, HIS365G, HIS409F, HIS409G, HIS412F, ILE452F, ILE452G, LEU134F, LEU134G, LEU138F, LEU138G, LEU143F, LEU143G, LEU168F, LEU168G, LEU30F, LEU30G, LEU31F, LEU31G, LEU37F, LEU37G, LEU380F, LEU380G, LEU401F, LEU401G, LEU403F, LEU403G, LEU40F, LEU40G, LYS139F, LYS139G, LYS148F, LYS148G, LYS159F, LYS159G, PHE140F, PHE140G, PHE164F, PHE164G, PHE335F, PHE335G, PHE36F, PHE36G, PHE376F, PHE376G, PRO141F, PRO141G, PRO151F, PRO151G, PRO169F, PRO169G, PRO28F, PRO28G, PRO384F, PRO384G, PRO399F, PRO399G, PRO400F, PRO400G, PRO449F, PRO449G, PRO49F, PRO49G, SER157F, SER157G, SER167F, SER167G, SER378F, SER378G, SER397F, SER397G, THR153F, THR153G, THR166F, THR166G, THR22F, THR22G, THR379F, THR379G, TRP162F, TRP162G, TRP165F, TRP165G, TRP390F, TRP390G, TRP410F, TRP410G, TYR343F, TYR343G, TYR364F, TYR364G, TYR382F, TYR382G, VAL147F, VAL147G, VAL20F, VAL20G, VAL347F, VAL347G
• F-H: ALA10F, ALA10H, ALA15F, ALA15H, ALA23F, ALA23H, ALA306F, ALA306H, ALA316F, ALA316H, ALA336F, ALA336H, ALA340F, ALA340H, ALA356F, ALA356H, ALA369F, ALA369H, ALA391F, ALA391H, ALA407F, ALA407H, ALA408F, ALA41F, ALA41H, ALA9F, ALA9H, ARG208F, ARG208H, ARG333F, ARG333H, ARG342F, ARG342H, ARG344F, ARG344H, ARG358F, ARG358H, ARG366F, ARG366H, ARG371F, ARG371H, ARG45F, ARG45H, ARG99F, ARG99H, ASN121F, ASN121H, ASN17F, ASN17H, ASN19F, ASN19H, ASN206H, ASN300F, ASN303F, ASN303H, ASN314F, ASN314H, ASN317F, ASN317H, ASN348F, ASN348H, ASN355F, ASN355H, ASN375F, ASN375H, ASN385F, ASN385H, ASP123F, ASP123H, ASP327F, ASP327H, ASP339F, ASP339H, ASP33F, ASP33H, ASP367F, ASP367H, ASP373F, ASP373H, ASP386F, ASP386H, ASP395F, ASP395H, ASP44F, ASP44H, CYS12F, CYS12H, CYS359F, CYS359H, GLN18F, GLN18H, GLN21F, GLN21H, GLN302F, GLN302H, GLN310F, GLN310H, GLN32F, GLN32H, GLN331F, GLN331H, GLN350F, GLN350H, GLN387F, GLN387H, GLN389F, GLN389H, GLN393F, GLN393H, GLU118F, GLU118H, GLU119F, GLU119H, GLU307F, GLU307H, GLU309F, GLU309H, GLU383F, GLU383H, GLU38F, GLU38H, GLU392F, GLU392H, GLU398F, GLU398H, GLU46F, GLU46H, GLY11F, GLY11H, GLY120F, GLY120H, GLY24F, GLY24H, GLY27F, GLY27H, GLY332F, GLY332H, GLY338F, GLY338H, GLY346F, GLY346H, GLY368F, GLY368H, GLY374F, GLY374H, GLY377F, GLY377H, GLY381F, GLY381H, GLY388F, GLY388H, GLY405F, GLY405H, HIS16F, HIS16H, HIS349F, HIS349H, HIS351F, HIS351H, HIS362F, HIS362H, HIS365F, HIS365H, HIS42F, HIS42H, ILE322F, ILE322H, ILE352F, ILE352H, ILE48F, ILE48H, LEU30F, LEU30H, LEU31F, LEU31H, LEU330F, LEU330H, LEU334F, LEU334H, LEU345F, LEU345H, LEU37F, LEU37H, LEU380F, LEU380H, LEU401F, LEU401H, LEU403F, LEU403H, LEU40F, LEU40H, LEU6F, LEU6H, LYS114F, LYS114H, LYS328F, LYS328H, LYS39F, LYS39H, LYS4F, LYS4H, LYS5F, LYS5H, LYS75F, LYS75H, LYS77F, MET370F, MET370H, PHE115F, PHE115H, PHE305F, PHE305H, PHE324F, PHE324H, PHE335F, PHE335H, PHE36F, PHE36H, PHE376F, PHE376H, PHE396F, PHE396H, PHE43F, PHE43H, PRO137F, PRO137H, PRO13F, PRO13H, PRO28F, PRO28H, PRO301F, PRO301H, PRO315F, PRO315H, PRO320F, PRO320H, PRO326F, PRO326H, PRO353F, PRO353H, PRO357F, PRO357H, PRO360F, PRO360H, PRO384F, PRO384H, PRO394F, PRO394H, PRO399F, PRO399H, PRO400F, PRO400H, PRO49F, PRO49H, SER200F, SER323F, SER323H, SER325F, SER325H, SER363F, SER363H, SER378F, SER378H, SER397F, SER397H, SER3F, SER3H, THR117F, THR117H, THR22F, THR22H, THR379F, THR379H, THR7F, THR7H, THR8F, THR8H, TRP122F, TRP122H, TRP210F, TRP210H, TRP35F, TRP35H, TRP390F, TRP390H, TYR116F, TYR116H, TYR304F, TYR304H, TYR337F, TYR343F, TYR343H, TYR364F, TYR364H, TYR382F, TYR382H, VAL14F, VAL14H, VAL318F, VAL318H, VAL319F, VAL319H, VAL347F, VAL347H, VAL34F, VAL34H, VAL354F, VAL354H, VAL361F, VAL361H, VAL372F, VAL372H, VAL47F, VAL47H
• G-H: ALA101G, ALA101H, ALA102G, ALA102H, ALA104G, ALA104H, ALA146G, ALA158G, ALA158H, ALA15G, ALA15H, ALA227G, ALA227H, ALA229G, ALA229H, ALA23G, ALA23H, ALA268G, ALA268H, ALA269G, ALA269H, ALA306G, ALA306H, ALA336G, ALA336H, ALA340G, ALA340H, ALA406G, ALA406H, ALA407G, ALA407H, ALA408G, ALA408H, ALA41G, ALA41H, ALA55G, ALA55H, ALA96G, ALA96H, ARG106G, ARG106H, ARG135G, ARG135H, ARG149G, ARG149H, ARG152G, ARG152H, ARG156G, ARG156H, ARG237G, ARG237H, ARG242G, ARG242H, ARG26G, ARG26H, ARG299G, ARG299H, ARG333G, ARG333H, ARG342G, ARG342H, ARG344G, ARG344H, ARG413G, ARG413H, ARG45G, ARG45H, ARG51G, ARG51H, ARG52G, ARG52H, ARG91G, ARG91H, ARG99G, ARG99H, ASN144G, ASN144H, ASN154G, ASN154H, ASN17G, ASN17H, ASN19G, ASN19H, ASN235G, ASN235H, ASN274G, ASN274H, ASN300G, ASN300H, ASN303G, ASN303H, ASN402G, ASN402H, ASP103G, ASP103H, ASP136G, ASP136H, ASP142G, ASP142H, ASP150G, ASP150H, ASP226G, ASP226H, ASP236G, ASP236H, ASP243G, ASP243H, ASP246G, ASP246H, ASP249G, ASP249H, ASP277G, ASP277H, ASP327G, ASP327H, ASP339G, ASP339H, ASP33G, ASP33H, ASP404G, ASP404H, ASP411G, ASP411H, ASP415G, ASP415H, ASP44G, ASP44H, GLN18G, GLN18H, GLN21G, GLN21H, GLN241G, GLN241H, GLN251G, GLN29G, GLN29H, GLN302G, GLN302H, GLN32G, GLN32H, GLN331G, GLN331H, GLN341G, GLN341H, GLU105G, GLU105H, GLU170G, GLU170H, GLU231G, GLU231H, GLU238G, GLU238H, GLU307G, GLU307H, GLU309G, GLU309H, GLU38G, GLU38H, GLU414G, GLU414H, GLU46G, GLU46H, GLU50G, GLU50H, GLU98G, GLU98H, GLY100G, GLY100H, GLY230G, GLY230H, GLY234G, GLY234H, GLY24G, GLY24H, GLY27G, GLY27H, GLY332G, GLY332H, GLY338G, GLY338H, GLY405G, GLY405H, GLY57G, GLY57H, GLY59G, GLY59H, GLY97G, GLY97H, HIS145G, HIS145H, HIS16G, HIS16H, HIS240G, HIS240H, HIS409G, HIS409H, HIS412G, HIS412H, HIS42G, HIS42H, HIS54H, ILE248G, ILE248H, ILE48G, ILE48H, LEU138G, LEU138H, LEU143G, LEU143H, LEU168G, LEU168H, LEU232G, LEU232H, LEU244G, LEU244H, LEU245G, LEU245H, LEU30G, LEU30H, LEU31G, LEU31H, LEU330G, LEU330H, LEU334G, LEU334H, LEU37G, LEU37H, LEU401G, LEU401H, LEU403G, LEU403H, LEU40G, LEU40H, LEU6G, LEU6H, LYS139G, LYS139H, LYS148G, LYS148H, LYS25G, LYS25H, LYS280G, LYS280H, LYS328G, LYS328H, LYS39G, LYS39H, LYS56G, LYS56H, MET155G, MET155H, MET329G, MET329H, PHE140G, PHE140H, PHE164G, PHE164H, PHE276G, PHE276H, PHE305G, PHE305H, PHE324G, PHE324H, PHE335G, PHE335H, PHE36G, PHE36H, PHE43G, PHE43H, PRO137G, PRO137H, PRO141G, PRO141H, PRO151G, PRO151H, PRO272G, PRO272H, PRO275G, PRO275H, PRO28G, PRO28H, PRO301G, PRO301H, PRO326G, PRO326H, PRO49G, PRO49H, SER157G, SER157H, SER239G, SER239H, SER325G, SER325H, SER58G, SER58H, THR153G, THR153H, THR22G, THR22H, THR270G, THR270H, TRP210G, TRP210H, TRP35G, TRP35H, TRP410G, TRP410H, TYR273G, TYR273H, TYR304G, TYR304H, TYR337G, TYR337H, TYR343G, TYR343H, VAL14G, VAL14H, VAL20G, VAL20H, VAL233G, VAL233H, VAL271G, VAL271H, VAL308G, VAL308H, VAL34G, VAL34H, VAL47G, VAL47H