2IO1

crystal structure of human senp2 in complex with presumo-3

• Total interactions analyzed: 15
• Total true interactions: 10
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 111
  • Norm. En. per Res.: -5.6626
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-73.4138	-191.0407	-364.098	-628.5525	111	28	2	12475	13	43	18
A-C	-5.8585	-11.743	-66.3658	-83.9673	39	1	0	2574	0	7	17
A-D	0.0	0.0	-50.6774	-50.6774	31	0	0	1923	0	7	6
A-E	-9.7181	-6.206	-36.9153	-52.8394	23	3	0	1410	1	13	11
B-C	-9.2443	-26.9544	-29.1965	-65.3952	27	1	0	1453	1	5	7
B-D	0.0	-6.7729	-10.6697	-17.4426	14	0	0	669	0	4	1
B-E	0.0	0.0	-0.6748	-0.6748	9	0	0	96	0	4	5
C-D	-102.9473	-149.8714	-344.367	-597.1857	109	28	2	11381	10	41	18
C-E	-13.9018	-80.9942	-90.8548	-185.7508	58	12	1	4411	1	46	31
E-F	-87.0998	-150.5966	-334.5	-572.1964	108	32	2	11383	6	41	18

Interface residues

• A-B: ALA22B, ALA392A, ALA453A, ARG396A, ARG456A, ARG475A, ARG55B, ARG576A, ARG58B, ARG60B, ASN412A, ASN417A, ASN421A, ASN544A, ASN67B, ASP386A, ASP401A, ASP413A, ASP495A, ASP547A, ASP62B, ASP70B, ASP81B, ASP84B, GLN24B, GLN385A, GLN499A, GLN542A, GLN56B, GLN64B, GLN74B, GLN87B, GLN88B, GLN89B, GLU387A, GLU414A, GLU68B, GLU76B, GLU78B, GLU95B, GLY23B, GLY400A, GLY498A, GLY545A, GLY549A, GLY63B, GLY91B, GLY92B, HIS409A, HIS436A, HIS474A, HIS478A, ILE416A, ILE473A, ILE57B, ILE66B, ILE83B, LEU395A, LEU411A, LEU446A, LEU543A, LEU75B, LYS394A, LYS445A, LYS455A, LYS459A, LYS476A, MET497A, MET54B, MET550A, MET77B, PHE393A, PHE438A, PHE441A, PHE442A, PHE551A, PHE59B, PHE61B, PHE86B, PRO384A, PRO444A, PRO472A, PRO65B, PRO94B, SER439A, SER448A, SER480A, SER496A, SER546A, SER548A, THR398A, THR404A, THR440A, THR458A, THR69B, THR71B, THR82B, THR90B, TRP410A, TRP457A, TRP479A, TYR408A, TYR443A, TYR493A, VAL415A, VAL437A, VAL454A, VAL461A, VAL477A, VAL85B, VAL93B
• A-C: ALA392C, ARG396C, ARG399A, ARG426C, ASN421C, ASP386A, GLN385A, GLN403A, GLN586C, GLN587C, GLU375C, GLU387A, GLU387C, GLU425C, GLY381A, GLY383A, GLY400A, HIS382A, HIS409A, HIS585C, ILE388C, ILE397C, ILE583C, LEU380A, LEU389C, LEU422C, LEU584C, LYS394C, LYS406A, LYS428C, LYS429C, PHE393C, PHE418C, PRO384A, SER390C, SER391C, TRP581C, TYR408A, VAL424C
• A-D: ALA73D, ARG35D, ARG576A, ASN407A, ASN544A, ASN67D, ASP547A, ASP70D, GLN542A, GLN74D, GLU68D, GLU76D, GLY545A, HIS36D, HIS409A, LEU39D, LEU543A, LEU75D, LYS406A, LYS41D, MET497A, PRO38D, PRO72D, SER40D, SER546A, THR37D, THR69D, THR71D, TRP410A, TYR408A, VAL477A
• A-E: ALA434E, ARG396A, ARG399A, ARG426E, ASN427E, ASP386A, GLN430E, GLN586A, GLN587E, GLU387A, GLU425E, GLU467E, GLY431E, ILE388A, LEU389A, LYS428E, LYS429E, PRO384A, PRO433E, SER390A, SER391A, THR398A, TYR432E
• B-C: ALA379C, ARG399C, ARG55B, ASN378C, ASP386C, CYS47B, GLN385C, GLN50B, GLN56B, GLN88B, GLU375C, GLU387C, GLU48B, GLY383C, GLY51B, HIS382C, ILE388C, ILE57B, LEU389C, LEU52B, LEU584C, LYS374C, LYS44B, MET54B, PRO384C, SER390C, SER53B
• B-D: GLN74D, GLU95B, GLY91B, GLY92B, HIS36D, LYS34D, LYS41D, PRO38D, PRO94B, THR37D, THR69D, THR71D, THR90B, VAL93B
• B-E: ALA434E, ARG487E, GLN74B, GLU467E, GLU68B, GLY431E, PRO433E, THR69B, TYR432E
• C-D: ALA22D, ALA392C, ALA453C, ARG396C, ARG456C, ARG475C, ARG55D, ARG576C, ARG58D, ARG60D, ASN412C, ASN417C, ASN421C, ASN544C, ASN67D, ASP386C, ASP401C, ASP413C, ASP547C, ASP62D, ASP70D, ASP81D, ASP84D, GLN24D, GLN385C, GLN542C, GLN56D, GLN64D, GLN74D, GLN87D, GLN88D, GLN89D, GLU387C, GLU414C, GLU68D, GLU76D, GLU78D, GLU95D, GLY23D, GLY26D, GLY400C, GLY545C, GLY549C, GLY63D, GLY91D, GLY92D, HIS409C, HIS436C, HIS474C, HIS478C, ILE416C, ILE473C, ILE57D, ILE66D, ILE83D, LEU395C, LEU39D, LEU411C, LEU446C, LEU543C, LEU75D, LYS394C, LYS445C, LYS455C, LYS459C, LYS476C, MET497C, MET54D, MET550C, MET77D, PHE393C, PHE418C, PHE438C, PHE441C, PHE442C, PHE61D, PHE86D, PRO384C, PRO444C, PRO472C, PRO65D, PRO94D, SER391C, SER439C, SER448C, SER480C, SER546C, SER548C, SER96D, THR398C, THR404C, THR440C, THR458C, THR69D, THR71D, THR82D, THR90D, TRP410C, TRP457C, TRP479C, TYR408C, TYR443C, VAL415C, VAL437C, VAL454C, VAL461C, VAL477C, VAL85D, VAL93D
• C-E: ARG426C, ARG426E, ARG561C, ARG561E, ASP371C, ASP371E, ASP557C, ASP557E, GLN430C, GLN430E, GLN571E, GLN587C, GLN587E, GLU367C, GLU367E, GLU370C, GLU370E, GLU373C, GLU373E, GLU375C, GLU375E, GLU582C, GLU582E, HIS585C, HIS585E, LEU366C, LEU368C, LEU368E, LEU574C, LEU574E, LEU588C, LEU588E, LEU589C, LEU589E, LYS374C, LYS374E, LYS429C, LYS554C, LYS554E, LYS563C, LYS563E, LYS578C, LYS578E, MET372C, MET372E, PHE575C, PHE575E, PRO564C, THR369C, THR369E, THR566C, THR566E, TRP581C, TRP581E, TYR432C, TYR432E, TYR558C, TYR558E
• E-F: ALA22F, ALA392E, ALA453E, ARG396E, ARG456E, ARG475E, ARG55F, ARG576E, ARG58F, ARG60F, ASN412E, ASN417E, ASN421E, ASN544E, ASN67F, ASP386E, ASP401E, ASP413E, ASP547E, ASP62F, ASP70F, ASP81F, ASP84F, GLN24F, GLN385E, GLN499E, GLN542E, GLN56F, GLN64F, GLN74F, GLN87F, GLN88F, GLN89F, GLU387E, GLU414E, GLU68F, GLU76F, GLU78F, GLU95F, GLY23F, GLY400E, GLY545E, GLY549E, GLY63F, GLY91F, GLY92F, HIS409E, HIS436E, HIS474E, HIS478E, ILE416E, ILE473E, ILE57F, ILE66F, ILE83F, LEU395E, LEU39F, LEU411E, LEU446E, LEU543E, LEU75F, LYS394E, LYS445E, LYS455E, LYS459E, LYS476E, MET43F, MET497E, MET550E, MET77F, PHE393E, PHE438E, PHE441E, PHE442E, PHE59F, PHE61F, PHE86F, PRO384E, PRO444E, PRO472E, PRO65F, PRO94F, SER439E, SER448E, SER480E, SER53F, SER546E, SER548E, THR398E, THR404E, THR440E, THR458E, THR69F, THR71F, THR82F, THR90F, TRP410E, TRP457E, TRP479E, TYR408E, TYR443E, VAL415E, VAL437E, VAL454E, VAL461E, VAL477E, VAL85F, VAL93F