2IK8

crystal structure of the heterodimeric complex of human rgs16 and activated gi alpha 1

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 90
  • Norm. En. per Res.: -4.2323
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-62.6549	-64.2515	-201.808	-328.7144	94	13	1	7645	3	73	60
A-C	0.0	-16.8582	-95.7899	-112.6481	47	4	2	4142	1	21	28
A-D	0.0	-4.9489	-31.6593	-36.6082	25	0	0	1358	0	19	18
B-C	0.0	0.0	-10.3165	-10.3165	22	0	0	782	0	20	16
C-D	-72.5848	-92.0172	-216.308	-380.91	90	15	1	8279	6	76	62

Interface residues

• A-B: ALA126B, ALA235A, ALA71A, ARG137B, ARG170B, ARG178A, ARG205A, ARG208A, ARG86A, ARG90A, ASN131B, ASN76A, ASN91B, ASP133B, ASP166B, ASP200A, ASP237A, CYS123B, CYS214A, GLN147A, GLN204A, GLN68A, GLN79A, GLU120B, GLU125B, GLU129B, GLU135B, GLU138B, GLU164B, GLU186A, GLU207A, GLU236A, GLU238A, GLU239A, GLU86B, GLU89B, GLU90B, GLY183A, GLY202A, GLY203A, GLY42A, HIS134B, HIS213A, ILE122B, ILE132B, ILE184A, ILE212A, LEU139B, LEU162B, LEU172B, LEU234A, LEU83B, LEU92B, LYS128B, LYS158B, LYS165B, LYS173B, LYS180A, LYS209A, LYS210A, LYS84B, MET163B, MET240A, PHE121B, PHE199A, PHE79B, PHE82B, PHE87B, PRO127B, PRO169B, SER124B, SER167B, SER206A, SER47A, SER75A, SER88B, THR136B, THR159B, THR161B, THR181A, THR182A, THR187A, THR85B, TRP211A, TYR146A, TYR168B, TYR69A, VAL130B, VAL179A, VAL185A, VAL201A, VAL233A, VAL50A, VAL72A
• A-C: ARG205A, ARG205C, ARG208A, ARG208C, ARG313A, ARG313C, ASN256A, ASN256C, ASP261A, ASP261C, CYS214A, CYS214C, GLU207C, GLU216A, GLU216C, GLY217A, GLY217C, HIS213A, HIS213C, ILE184C, ILE212A, ILE212C, ILE253C, LEU249C, LEU37A, LEU39C, LYS209A, LYS209C, LYS210A, LYS210C, LYS257A, LYS257C, LYS35A, PHE215A, PHE215C, PHE259A, PHE259C, SER206C, SER252C, THR260A, THR260C, TRP211A, TRP211C, TRP258A, TRP258C, VAL218A, VAL218C
• A-D: ALA126D, ARG141D, ARG313A, ASN255A, ASN256A, ASP261A, ASP315A, CYS123D, GLU119D, GLU120D, GLU125D, GLU129D, GLU216A, LYS128D, LYS257A, LYS317A, PHE118D, PHE259A, PHE87D, PRO127D, SER124D, THR260A, THR262A, THR316A, TRP258A
• B-C: ALA126B, ARG313C, ASP261C, ASP315C, CYS123B, GLU119B, GLU120B, GLU125B, GLU129B, GLU216C, GLY217C, LYS128B, LYS257C, LYS312C, LYS314C, LYS317C, PHE87B, PRO127B, SER124B, THR260C, THR316C, TRP258C
• C-D: ALA126D, ALA235C, ALA71C, ARG137D, ARG170D, ARG178C, ARG205C, ARG208C, ARG86C, ARG90C, ASN131D, ASN76C, ASN91D, ASP133D, ASP166D, ASP200C, ASP237C, CYS123D, CYS214C, GLN147C, GLN204C, GLN68C, GLN79C, GLU120D, GLU125D, GLU129D, GLU135D, GLU138D, GLU164D, GLU186C, GLU207C, GLU236C, GLU238C, GLU239C, GLU65C, GLU86D, GLU89D, GLU90D, GLY183C, GLY202C, GLY203C, GLY42C, HIS134D, HIS213C, ILE122D, ILE132D, ILE184C, LEU162D, LEU234C, LEU83D, LYS128D, LYS158D, LYS165D, LYS173D, LYS180C, LYS209C, LYS210C, LYS51C, LYS84D, MET163D, PHE121D, PHE199C, PHE82D, PHE87D, PRO127D, PRO169D, SER124D, SER167D, SER206C, SER47C, SER75C, SER88D, THR136D, THR159D, THR161D, THR181C, THR182C, THR187C, THR85D, TRP211C, TYR146C, TYR168D, TYR69C, VAL130D, VAL179C, VAL185C, VAL201C, VAL233C, VAL50C, VAL72C