2IGK

crystal structure of recombinant pyranose 2-oxidase

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 267
  • Norm. En. per Res.: -3.6596
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-213.9533	-51.6598	-711.51	-977.123	267	29	16	28738	4	61	45
A-C	0.0	-5.6397	-104.841	-110.4807	80	3	2	4962	0	16	14
A-D	-27.3008	28.01	-266.228	-265.5188	114	5	4	10693	0	4	8
B-C	-14.3963	29.0075	-265.632	-251.0208	114	3	4	10758	0	4	8
B-D	0.0	-6.1075	-106.333	-112.4405	81	2	2	4936	0	16	13
C-D	-193.2585	-49.9241	-691.818	-935.0006	263	33	16	28351	4	62	44
E-F	-199.8164	-47.3648	-682.47	-929.6512	266	42	16	28373	4	60	43
E-G	0.0	-6.1323	-104.757	-110.8893	80	2	2	4914	0	16	14
E-H	-30.2012	28.1582	-266.254	-268.2971	113	5	5	10635	0	4	8
F-G	-7.3775	28.1564	-257.846	-237.0671	114	3	3	10463	0	4	8
F-H	0.0	-5.7715	-106.863	-112.6345	79	5	2	5051	0	16	15
G-H	-191.8271	-50.843	-695.401	-938.071	268	30	16	28578	4	61	45

Interface residues

• A-B: ALA133A, ALA133B, ALA156A, ALA156B, ALA280A, ALA280B, ALA282A, ALA282B, ALA458A, ALA458B, ALA494A, ALA494B, ALA527A, ALA527B, ARG139A, ARG139B, ARG159A, ARG159B, ARG246A, ARG246B, ARG451A, ARG451B, ARG466A, ARG466B, ASN105A, ASN105B, ASN119A, ASN119B, ASN140A, ASN140B, ASN264A, ASN264B, ASN496A, ASN496B, ASN92A, ASN92B, ASN99A, ASN99B, ASP101A, ASP101B, ASP124A, ASP124B, ASP302A, ASP302B, ASP374A, ASP374B, ASP422A, ASP422B, ASP464A, ASP464B, ASP493A, ASP493B, ASP81A, ASP81B, GLN108A, GLN108B, GLN110A, GLN110B, GLN132A, GLN132B, GLN263A, GLN263B, GLN418A, GLN460A, GLN460B, GLN461A, GLN461B, GLN97A, GLN97B, GLU371A, GLU371B, GLU421A, GLU421B, GLU429A, GLU429B, GLU79A, GLU79B, GLU95A, GLU95B, GLY109A, GLY109B, GLY141A, GLY141B, GLY457A, GLY457B, GLY530A, GLY530B, GLY531A, GLY531B, GLY535A, GLY535B, GLY78A, GLY78B, GLY83A, GLY83B, GLY87A, GLY87B, HIS301A, HIS301B, HIS324B, HIS415A, HIS415B, HIS419A, HIS419B, ILE100A, ILE100B, ILE107A, ILE107B, ILE304A, ILE304B, ILE373A, ILE373B, ILE463A, ILE463B, ILE468A, ILE468B, ILE491A, ILE491B, ILE529A, ILE529B, ILE77A, ILE77B, ILE80A, ILE80B, ILE86A, ILE86B, LEU111A, LEU111B, LEU121A, LEU121B, LEU126A, LEU126B, LEU277A, LEU277B, LEU303A, LEU303B, LEU372A, LEU372B, LEU424A, LEU424B, LEU467A, LEU467B, LEU533A, LEU533B, LEU537A, LEU537B, LEU84A, LEU84B, LYS102A, LYS102B, LYS377A, LYS377B, LYS490A, LYS490B, LYS528A, LYS528B, LYS85A, LYS85B, LYS90A, LYS90B, LYS98A, LYS98B, MET112A, MET112B, MET368A, MET368B, PHE103A, PHE103B, PHE136A, PHE136B, PHE137A, PHE137B, PHE250A, PHE250B, PHE428A, PHE428B, PHE532A, PHE532B, PRO128A, PRO128B, PRO144A, PRO144B, PRO279A, PRO279B, PRO423A, PRO423B, PRO425A, PRO425B, PRO534A, PRO534B, SER113A, SER113B, SER127A, SER127B, SER130A, SER130B, SER134A, SER134B, SER142A, SER142B, SER247A, SER247B, SER369A, SER369B, SER375B, SER462A, SER462B, SER465A, SER465B, SER526B, SER82A, SER82B, THR120A, THR120B, THR125A, THR125B, THR129A, THR129B, THR135A, THR135B, THR158A, THR158B, THR249A, THR366A, THR366B, THR370A, THR370B, THR492A, THR492B, THR93A, THR93B, TRP131A, TRP131B, TYR456A, TYR456B, TYR495A, TYR495B, TYR96A, TYR96B, VAL104A, VAL104B, VAL106A, VAL106B, VAL116A, VAL116B, VAL118A, VAL118B, VAL122A, VAL122B, VAL123A, VAL123B, VAL138A, VAL138B, VAL157A, VAL157B, VAL160A, VAL160B, VAL161A, VAL161B, VAL281A, VAL281B, VAL367A, VAL367B, VAL459A, VAL459B, VAL94A, VAL94B
• A-C: ALA458A, ALA458C, ALA508A, ALA508C, ALA527A, ALA527C, ARG505A, ASP517A, ASP517C, ASP521A, ASP521C, CYS364A, CYS364C, CYS523A, CYS523C, GLN539A, GLN539C, GLU371A, GLU371C, GLU516A, GLU516C, GLY509A, GLY509C, GLY530A, GLY530C, GLY531A, GLY531C, GLY535A, GLY535C, ILE529A, ILE529C, LEU121A, LEU121C, LEU149A, LEU149C, LEU537A, LEU537C, LYS513A, LYS513C, LYS528A, LYS528C, MET519A, MET519C, MET522A, MET522C, MET525A, MET525C, MET541A, PHE363A, PHE363C, PHE532A, PHE532C, PHE540A, PHE540C, PRO534A, PRO534C, PRO538A, PRO538C, SER369A, SER369C, SER462A, SER462C, SER512A, SER512C, SER526A, SER526C, SER536A, SER536C, THR366A, THR366C, THR370A, THR370C, THR520A, THR520C, VAL362A, VAL362C, VAL459A, VAL459C, VAL524A, VAL524C
• A-D: ALA133A, ALA133D, ALA508A, ALA508D, ALA515A, ALA515D, ARG139A, ARG139D, ARG150A, ARG150D, ARG505A, ARG505D, ARG510A, ARG510D, ASN119A, ASN119D, ASN151A, ASN151D, ASP124A, ASP124D, ASP147A, ASP147D, ASP517A, ASP517D, GLN132A, GLN132D, GLN539A, GLN539D, GLU514A, GLU514D, GLU516A, GLU516D, GLU542A, GLU542D, GLY154A, GLY154D, GLY475A, GLY475D, GLY509A, GLY509D, LEU121A, LEU121D, LEU126A, LEU126D, LEU149A, LEU149D, LEU152A, LEU152D, LEU361A, LEU361D, LEU545A, LEU545D, LYS513A, LYS513D, MET518A, MET518D, MET519A, MET519D, MET541A, MET541D, PHE136A, PHE136D, PHE137A, PHE137D, PHE504A, PHE504D, PHE506A, PHE506D, PHE540A, PHE540D, PRO117A, PRO117D, PRO128A, PRO128D, PRO148A, PRO148D, PRO507A, PRO507D, PRO543A, PRO543D, SER127A, SER127D, SER130A, SER130D, SER134A, SER134D, SER153A, SER153D, SER360A, SER360D, SER512A, SER512D, THR120A, THR120D, THR125A, THR125D, THR129A, THR129D, THR135A, THR135D, THR477A, THR477D, THR511A, THR511D, TRP131A, TRP131D, VAL118A, VAL118D, VAL122A, VAL122D, VAL123A, VAL123D, VAL362A, VAL362D
• B-C: ALA133B, ALA133C, ALA508B, ALA508C, ALA515B, ALA515C, ARG139B, ARG139C, ARG150B, ARG150C, ARG505B, ARG505C, ARG510B, ARG510C, ASN119B, ASN119C, ASN151B, ASN151C, ASP124B, ASP124C, ASP147B, ASP147C, ASP517B, ASP517C, GLN132B, GLN132C, GLN539B, GLN539C, GLU514B, GLU514C, GLU516B, GLU516C, GLU542B, GLU542C, GLY154B, GLY154C, GLY475B, GLY475C, GLY509B, GLY509C, LEU121B, LEU121C, LEU126B, LEU126C, LEU149B, LEU149C, LEU152B, LEU152C, LEU361B, LEU361C, LEU545B, LEU545C, LYS513B, LYS513C, MET518B, MET518C, MET519B, MET519C, MET541B, MET541C, PHE136B, PHE136C, PHE137B, PHE137C, PHE504B, PHE504C, PHE506B, PHE506C, PHE540B, PHE540C, PRO117B, PRO117C, PRO128B, PRO128C, PRO148B, PRO148C, PRO507B, PRO507C, PRO543B, PRO543C, SER127B, SER127C, SER130B, SER130C, SER134B, SER134C, SER153B, SER153C, SER360B, SER360C, SER512B, SER512C, THR120B, THR120C, THR125B, THR125C, THR129B, THR129C, THR135B, THR135C, THR477B, THR511B, THR511C, THR520B, TRP131B, TRP131C, VAL118B, VAL118C, VAL122B, VAL122C, VAL123B, VAL123C, VAL362B, VAL362C
• B-D: ALA458B, ALA458D, ALA508B, ALA508D, ALA527B, ALA527D, ARG505B, ASP517B, ASP517D, ASP521B, ASP521D, CYS364B, CYS364D, CYS523B, CYS523D, GLN539B, GLN539D, GLU371B, GLU371D, GLU516B, GLU516D, GLY509B, GLY509D, GLY530B, GLY530D, GLY531B, GLY531D, GLY535B, GLY535D, ILE529B, ILE529D, LEU121B, LEU121D, LEU149B, LEU149D, LEU537B, LEU537D, LYS225B, LYS225D, LYS513B, LYS513D, LYS528B, LYS528D, MET519B, MET519D, MET522B, MET522D, MET525B, MET525D, PHE363B, PHE363D, PHE532B, PHE532D, PHE540B, PHE540D, PRO534B, PRO534D, PRO538B, PRO538D, SER369B, SER369D, SER462B, SER462D, SER512B, SER512D, SER526B, SER526D, SER536B, SER536D, THR366B, THR366D, THR370B, THR370D, THR520B, THR520D, VAL362B, VAL362D, VAL459B, VAL459D, VAL524B, VAL524D
• C-D: ALA133C, ALA133D, ALA156C, ALA156D, ALA280C, ALA280D, ALA282C, ALA282D, ALA458C, ALA458D, ALA494C, ALA494D, ALA527C, ALA527D, ARG139C, ARG139D, ARG159C, ARG159D, ARG246C, ARG246D, ARG451C, ARG451D, ARG466C, ARG466D, ASN105C, ASN105D, ASN119C, ASN119D, ASN140C, ASN140D, ASN264C, ASN264D, ASN496C, ASN496D, ASN92C, ASN92D, ASN99C, ASN99D, ASP101C, ASP101D, ASP124C, ASP124D, ASP302C, ASP302D, ASP374C, ASP374D, ASP422C, ASP422D, ASP464C, ASP464D, ASP493C, ASP493D, ASP81C, ASP81D, GLN108C, GLN108D, GLN110C, GLN110D, GLN132C, GLN132D, GLN263C, GLN263D, GLN418C, GLN418D, GLN420C, GLN460C, GLN460D, GLN461C, GLN461D, GLN97C, GLN97D, GLU371C, GLU371D, GLU421C, GLU421D, GLU429D, GLU79C, GLU79D, GLU95C, GLU95D, GLY109C, GLY109D, GLY141C, GLY141D, GLY457C, GLY457D, GLY530C, GLY530D, GLY531C, GLY531D, GLY535C, GLY535D, GLY78C, GLY78D, GLY83C, GLY83D, GLY87C, HIS301C, HIS301D, HIS324C, HIS415C, HIS415D, HIS419C, ILE100C, ILE100D, ILE107C, ILE107D, ILE304C, ILE304D, ILE373C, ILE373D, ILE463C, ILE463D, ILE468C, ILE468D, ILE491C, ILE491D, ILE529C, ILE529D, ILE77C, ILE77D, ILE80C, ILE80D, ILE86C, ILE86D, LEU111C, LEU111D, LEU121C, LEU121D, LEU126C, LEU126D, LEU277C, LEU277D, LEU303C, LEU303D, LEU372C, LEU372D, LEU424C, LEU424D, LEU467C, LEU467D, LEU533C, LEU533D, LEU537C, LEU537D, LEU84C, LEU84D, LYS102C, LYS102D, LYS377C, LYS377D, LYS490C, LYS490D, LYS528C, LYS528D, LYS85C, LYS85D, LYS90C, LYS90D, LYS98C, LYS98D, MET112C, MET112D, MET368C, MET368D, MET497D, PHE103C, PHE103D, PHE136C, PHE136D, PHE137C, PHE137D, PHE250C, PHE250D, PHE428C, PHE428D, PHE532C, PHE532D, PRO128C, PRO128D, PRO144C, PRO144D, PRO279C, PRO279D, PRO423C, PRO423D, PRO425C, PRO425D, PRO534C, PRO534D, SER113C, SER113D, SER127C, SER127D, SER130C, SER130D, SER134C, SER134D, SER142C, SER142D, SER247C, SER247D, SER369C, SER369D, SER375D, SER462C, SER462D, SER465C, SER465D, SER82C, SER82D, THR120C, THR120D, THR125C, THR125D, THR129C, THR129D, THR135C, THR135D, THR158C, THR158D, THR366C, THR366D, THR370C, THR370D, THR93C, THR93D, TRP131C, TRP131D, TYR456C, TYR456D, TYR495C, TYR495D, TYR96C, TYR96D, VAL104C, VAL104D, VAL106C, VAL106D, VAL116C, VAL116D, VAL118C, VAL118D, VAL122C, VAL122D, VAL123C, VAL123D, VAL138C, VAL138D, VAL157C, VAL157D, VAL160C, VAL160D, VAL161C, VAL161D, VAL281C, VAL281D, VAL367C, VAL367D, VAL459C, VAL459D, VAL94C, VAL94D
• E-F: ALA133E, ALA133F, ALA156E, ALA156F, ALA280E, ALA280F, ALA282E, ALA282F, ALA458E, ALA458F, ALA494E, ALA494F, ALA527E, ALA527F, ARG139E, ARG139F, ARG159E, ARG159F, ARG246E, ARG246F, ARG451E, ARG451F, ARG466E, ARG466F, ASN105E, ASN105F, ASN119E, ASN119F, ASN140E, ASN140F, ASN264E, ASN264F, ASN496E, ASN496F, ASN92E, ASN92F, ASN99E, ASN99F, ASP101E, ASP101F, ASP124E, ASP124F, ASP302E, ASP302F, ASP374E, ASP374F, ASP422E, ASP422F, ASP464E, ASP464F, ASP493E, ASP493F, ASP81E, ASP81F, GLN108E, GLN108F, GLN110E, GLN110F, GLN132E, GLN132F, GLN263E, GLN263F, GLN418E, GLN418F, GLN420E, GLN420F, GLN460E, GLN460F, GLN461E, GLN461F, GLN97E, GLN97F, GLU371E, GLU371F, GLU421E, GLU421F, GLU429E, GLU429F, GLU79E, GLU79F, GLU95E, GLU95F, GLY109E, GLY109F, GLY141E, GLY141F, GLY457E, GLY457F, GLY530E, GLY530F, GLY531E, GLY531F, GLY535E, GLY535F, GLY78E, GLY78F, GLY83E, GLY83F, GLY87E, HIS301E, HIS301F, HIS415E, HIS415F, HIS419E, HIS419F, ILE100E, ILE100F, ILE107E, ILE107F, ILE304E, ILE304F, ILE373E, ILE373F, ILE463E, ILE463F, ILE468E, ILE468F, ILE491E, ILE491F, ILE529E, ILE529F, ILE77E, ILE77F, ILE80E, ILE80F, ILE86E, ILE86F, LEU111E, LEU111F, LEU121E, LEU121F, LEU126E, LEU126F, LEU277E, LEU277F, LEU303E, LEU303F, LEU372E, LEU372F, LEU424E, LEU424F, LEU467E, LEU467F, LEU533E, LEU533F, LEU537E, LEU537F, LEU84E, LEU84F, LYS102E, LYS102F, LYS377E, LYS377F, LYS490E, LYS490F, LYS528F, LYS85E, LYS85F, LYS90E, LYS90F, LYS98E, LYS98F, MET112E, MET112F, MET368E, MET368F, MET497E, PHE103E, PHE103F, PHE136E, PHE136F, PHE137E, PHE137F, PHE250E, PHE250F, PHE428E, PHE428F, PHE532E, PHE532F, PRO117F, PRO128E, PRO128F, PRO144E, PRO144F, PRO279E, PRO279F, PRO423E, PRO423F, PRO425E, PRO425F, PRO534E, PRO534F, SER113E, SER113F, SER127E, SER127F, SER130E, SER130F, SER134E, SER134F, SER142E, SER142F, SER247E, SER247F, SER369E, SER369F, SER375E, SER462E, SER462F, SER465E, SER465F, SER82E, SER82F, THR120E, THR120F, THR125E, THR125F, THR129E, THR129F, THR135E, THR135F, THR158E, THR158F, THR366E, THR366F, THR370E, THR370F, THR492F, THR93E, THR93F, TRP131E, TRP131F, TYR456E, TYR456F, TYR495E, TYR495F, TYR96E, TYR96F, VAL104E, VAL104F, VAL106E, VAL106F, VAL116E, VAL116F, VAL118E, VAL118F, VAL122E, VAL122F, VAL123E, VAL123F, VAL138E, VAL138F, VAL157E, VAL157F, VAL160E, VAL160F, VAL161E, VAL161F, VAL281E, VAL281F, VAL367E, VAL367F, VAL459E, VAL459F, VAL94E, VAL94F
• E-G: ALA458E, ALA458G, ALA508E, ALA508G, ALA527E, ALA527G, ASP517E, ASP517G, ASP521E, ASP521G, CYS364E, CYS364G, CYS523E, CYS523G, GLN539E, GLN539G, GLU371E, GLU371G, GLU516E, GLU516G, GLY509E, GLY509G, GLY530E, GLY530G, GLY531E, GLY531G, GLY535E, GLY535G, ILE529E, ILE529G, LEU121E, LEU121G, LEU149E, LEU149G, LEU537E, LEU537G, LYS225G, LYS513E, LYS513G, LYS528E, LYS528G, MET519E, MET519G, MET522E, MET522G, MET525E, MET525G, MET541E, PHE363E, PHE363G, PHE532E, PHE532G, PHE540E, PHE540G, PRO534E, PRO534G, PRO538E, PRO538G, SER369E, SER369G, SER462E, SER462G, SER512E, SER512G, SER526E, SER526G, SER536E, SER536G, THR366E, THR366G, THR370E, THR370G, THR520E, THR520G, VAL362E, VAL362G, VAL459E, VAL459G, VAL524E, VAL524G
• E-H: ALA133E, ALA133H, ALA508E, ALA508H, ALA515E, ALA515H, ARG139E, ARG139H, ARG150E, ARG150H, ARG505E, ARG505H, ARG510E, ASN119E, ASN119H, ASN151E, ASN151H, ASP124E, ASP124H, ASP147E, ASP147H, ASP517E, ASP517H, GLN132E, GLN132H, GLN539E, GLN539H, GLU514E, GLU514H, GLU516E, GLU516H, GLU542E, GLU542H, GLY154E, GLY154H, GLY475E, GLY475H, GLY509E, GLY509H, LEU121E, LEU121H, LEU126E, LEU126H, LEU149E, LEU149H, LEU152E, LEU152H, LEU361E, LEU361H, LEU545E, LEU545H, LYS513E, LYS513H, MET518E, MET518H, MET519E, MET519H, MET541E, MET541H, PHE136E, PHE136H, PHE137E, PHE137H, PHE504E, PHE504H, PHE506E, PHE506H, PHE540E, PHE540H, PRO117E, PRO117H, PRO128E, PRO128H, PRO148E, PRO148H, PRO507E, PRO507H, PRO543E, PRO543H, SER127E, SER127H, SER130E, SER130H, SER134E, SER134H, SER153E, SER153H, SER360E, SER360H, SER512E, SER512H, THR120E, THR120H, THR125E, THR125H, THR129E, THR129H, THR135E, THR135H, THR477E, THR477H, THR511E, THR511H, TRP131E, TRP131H, VAL118E, VAL118H, VAL122E, VAL122H, VAL123E, VAL123H, VAL362E, VAL362H
• F-G: ALA133F, ALA133G, ALA508F, ALA508G, ALA515F, ALA515G, ARG139F, ARG139G, ARG150F, ARG150G, ARG505F, ARG505G, ARG510G, ASN119F, ASN119G, ASN151F, ASN151G, ASP124F, ASP124G, ASP147F, ASP147G, ASP517F, ASP517G, GLN132F, GLN132G, GLN539F, GLN539G, GLU514F, GLU514G, GLU516F, GLU516G, GLU542F, GLU542G, GLY154F, GLY154G, GLY475F, GLY475G, GLY509F, GLY509G, LEU121F, LEU121G, LEU126F, LEU126G, LEU149F, LEU149G, LEU152F, LEU152G, LEU361F, LEU361G, LEU545F, LEU545G, LYS513F, LYS513G, MET518F, MET518G, MET519F, MET519G, MET541F, MET541G, PHE136F, PHE136G, PHE137F, PHE137G, PHE504F, PHE504G, PHE506F, PHE506G, PHE540F, PHE540G, PRO117F, PRO117G, PRO128F, PRO128G, PRO148F, PRO148G, PRO507F, PRO507G, PRO543F, PRO543G, SER127F, SER127G, SER130F, SER130G, SER134F, SER134G, SER153F, SER153G, SER360F, SER360G, SER512F, SER512G, THR120F, THR120G, THR125F, THR125G, THR129F, THR129G, THR135F, THR135G, THR477F, THR477G, THR511F, THR511G, THR520G, TRP131F, TRP131G, VAL118F, VAL118G, VAL122F, VAL122G, VAL123F, VAL123G, VAL362F, VAL362G
• F-H: ALA458F, ALA458H, ALA508F, ALA508H, ALA527F, ALA527H, ARG505H, ASP517F, ASP517H, ASP521F, ASP521H, CYS364F, CYS364H, CYS523F, CYS523H, GLN539F, GLN539H, GLU371F, GLU371H, GLU516F, GLU516H, GLY509F, GLY509H, GLY530F, GLY530H, GLY531F, GLY531H, GLY535F, GLY535H, ILE529F, ILE529H, LEU121F, LEU121H, LEU149F, LEU149H, LEU537F, LEU537H, LYS513F, LYS513H, LYS528F, LYS528H, MET519F, MET519H, MET522F, MET522H, MET525F, MET525H, PHE363F, PHE363H, PHE532F, PHE532H, PHE540F, PHE540H, PRO534F, PRO534H, PRO538F, PRO538H, SER369F, SER369H, SER462F, SER462H, SER512F, SER512H, SER526F, SER526H, SER536F, SER536H, THR366F, THR366H, THR370F, THR370H, THR520F, THR520H, VAL362F, VAL362H, VAL459F, VAL459H, VAL524F, VAL524H
• G-H: ALA133G, ALA133H, ALA156G, ALA156H, ALA280G, ALA280H, ALA282G, ALA282H, ALA458G, ALA458H, ALA494G, ALA494H, ALA527G, ALA527H, ARG139G, ARG139H, ARG159G, ARG159H, ARG246G, ARG246H, ARG451G, ARG451H, ARG466G, ARG466H, ASN105G, ASN105H, ASN119G, ASN119H, ASN140G, ASN140H, ASN264G, ASN264H, ASN496G, ASN496H, ASN92G, ASN92H, ASN99G, ASN99H, ASP101G, ASP101H, ASP124G, ASP124H, ASP302G, ASP302H, ASP374G, ASP374H, ASP422G, ASP422H, ASP464G, ASP464H, ASP493G, ASP493H, ASP81G, ASP81H, GLN108G, GLN108H, GLN110G, GLN110H, GLN132G, GLN132H, GLN263G, GLN263H, GLN418G, GLN418H, GLN420G, GLN420H, GLN460G, GLN460H, GLN461G, GLN461H, GLN97G, GLN97H, GLU371G, GLU371H, GLU421G, GLU421H, GLU429G, GLU429H, GLU79G, GLU79H, GLU95G, GLU95H, GLY109G, GLY109H, GLY141G, GLY141H, GLY457G, GLY457H, GLY530G, GLY530H, GLY531G, GLY531H, GLY535G, GLY535H, GLY78G, GLY78H, GLY83G, GLY83H, GLY87G, GLY87H, HIS301G, HIS301H, HIS415G, HIS419G, HIS419H, ILE100G, ILE100H, ILE107G, ILE107H, ILE304G, ILE304H, ILE373G, ILE373H, ILE463G, ILE463H, ILE468G, ILE468H, ILE491G, ILE491H, ILE529G, ILE529H, ILE77G, ILE77H, ILE80G, ILE80H, ILE86G, ILE86H, LEU111G, LEU111H, LEU121G, LEU121H, LEU126G, LEU126H, LEU277G, LEU277H, LEU303G, LEU303H, LEU372G, LEU372H, LEU424G, LEU424H, LEU467G, LEU467H, LEU533G, LEU533H, LEU537G, LEU537H, LEU84G, LEU84H, LYS102G, LYS102H, LYS377G, LYS377H, LYS490G, LYS490H, LYS528G, LYS528H, LYS85G, LYS85H, LYS90G, LYS90H, LYS98G, LYS98H, MET112G, MET112H, MET368G, MET368H, PHE103G, PHE103H, PHE136G, PHE136H, PHE137G, PHE137H, PHE250G, PHE250H, PHE428G, PHE428H, PHE532G, PHE532H, PRO128G, PRO128H, PRO144G, PRO144H, PRO279G, PRO279H, PRO423G, PRO423H, PRO425G, PRO425H, PRO534G, PRO534H, SER113G, SER113H, SER127G, SER127H, SER130G, SER130H, SER134G, SER134H, SER142G, SER142H, SER247G, SER247H, SER369G, SER369H, SER375G, SER455H, SER462G, SER462H, SER465G, SER465H, SER526G, SER82G, SER82H, THR120G, THR120H, THR125G, THR125H, THR129G, THR129H, THR135G, THR135H, THR158G, THR158H, THR366G, THR366H, THR370G, THR370H, THR492G, THR492H, THR93G, THR93H, TRP131G, TRP131H, TYR456G, TYR456H, TYR495G, TYR495H, TYR96G, TYR96H, VAL104G, VAL104H, VAL106G, VAL106H, VAL116G, VAL116H, VAL118G, VAL118H, VAL122G, VAL122H, VAL123G, VAL123H, VAL138G, VAL138H, VAL157G, VAL157H, VAL160G, VAL160H, VAL161G, VAL161H, VAL281G, VAL281H, VAL367G, VAL367H, VAL459G, VAL459H, VAL94G, VAL94H