2IFG

structure of the extracellular segment of human trka in complex with nerve growth factor

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 142
  • Norm. En. per Res.: -3.0998
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-E	-39.9821	-29.9638	-154.479	-224.4249	74	16	1	6767	4	19	24
A-F	-17.0258	0.0	-73.6173	-90.6431	43	6	1	3128	0	5	10
B-E	-11.7236	0.0	-77.1336	-88.8572	43	4	1	3198	0	5	8
B-F	-15.3996	-42.4809	-169.757	-227.6375	76	14	1	7064	4	19	24
E-F	-69.5397	34.3336	-404.962	-440.1681	142	22	17	17044	0	24	38

Interface residues

• A-E: ALA107E, ALA293A, ALA336A, ARG342A, ARG347A, ARG59E, ARG69E, ARG9E, ASN381A, ASP16E, ASP380A, CYS108E, CYS15E, CYS300A, CYS345A, GLN289A, GLN350A, GLU11E, GLU295A, GLU331A, GLU334A, GLU339A, GLU55E, GLY10E, GLY23E, GLY344A, HIS291A, HIS297A, HIS298A, HIS343A, HIS353A, HIS4E, HIS8E, ILE301A, ILE6E, LEU290A, LEU333A, LEU346A, LYS50E, MET296A, MET379A, PHE12E, PHE303A, PHE329A, PHE332A, PHE378A, PHE54E, PHE7E, PRO302A, PRO335A, PRO351A, PRO382A, PRO5E, SER13E, SER17E, SER19E, SER2E, SER304A, SER3E, THR106E, THR292A, THR352A, THR56E, TRP21E, TRP299A, TYR52E, VAL14E, VAL18E, VAL20E, VAL22E, VAL294A, VAL305A, VAL341A, VAL354A
• A-F: ALA107F, ALA28F, ARG103F, ARG347A, ASN349A, ASN355A, ASP105F, ASP30F, CYS110F, GLN350A, GLU35F, GLY33F, HIS297A, HIS298A, HIS353A, HIS84F, ILE104F, ILE31F, ILE328A, LEU112F, LEU348A, LYS32F, LYS34F, MET296A, MET379A, PHE101F, PHE327A, PHE329A, PHE86F, PRO351A, SER326A, THR106F, THR29F, THR325A, THR352A, THR81F, THR82F, THR83F, THR85F, TYR79F, VAL109F, VAL111F, VAL354A
• B-E: ALA107E, ALA28E, ARG103E, ARG347B, ASN349B, ASN355B, ASP105E, ASP30E, CYS110E, GLN350B, GLU35E, GLY33E, HIS297B, HIS298B, HIS353B, HIS84E, ILE104E, ILE31E, ILE328B, LEU112E, LEU348B, LYS32E, LYS34E, MET296B, MET379B, PHE101E, PHE327B, PHE86E, PRO351B, PRO382B, SER326B, THR106E, THR29E, THR325B, THR352B, THR81E, THR82E, THR83E, THR85E, TYR79E, VAL109E, VAL111E, VAL354B
• B-F: ALA107F, ALA293B, ALA336B, ALA337B, ARG342B, ARG347B, ARG59F, ARG69F, ARG9F, ASN381B, ASP16F, ASP380B, CYS108F, CYS15F, CYS300B, CYS345B, GLN289B, GLN350B, GLU11F, GLU295B, GLU331B, GLU334B, GLU339B, GLU55F, GLY10F, GLY23F, GLY344B, HIS291B, HIS297B, HIS298B, HIS343B, HIS353B, HIS4F, HIS8F, ILE301B, ILE6F, LEU290B, LEU333B, LEU346B, LYS50F, MET296B, MET379B, PHE12F, PHE303B, PHE329B, PHE332B, PHE378B, PHE53F, PHE54F, PHE7F, PRO302B, PRO335B, PRO351B, PRO382B, PRO5F, SER13F, SER17F, SER19F, SER2F, SER304B, SER3F, THR106F, THR292B, THR352B, THR56F, TRP21F, TRP299B, TYR52F, VAL14F, VAL18F, VAL20F, VAL22F, VAL294B, VAL305B, VAL341B, VAL354B
• E-F: ALA107E, ALA107F, ALA116F, ALA89E, ALA89F, ALA97E, ALA97F, ALA98E, ALA98F, ARG100E, ARG100F, ARG103E, ARG103F, ARG114E, ARG114F, ARG69E, ARG69F, ARG9E, ARG9F, ASN43E, ASN43F, ASN45E, ASN45F, ASN46E, ASN46F, ASN77E, ASN77F, ASP105E, ASP105F, ASP72E, ASP72F, CYS108E, CYS108F, CYS110E, CYS110F, CYS15E, CYS15F, CYS68E, CYS68F, GLN51E, GLN51F, GLU11E, GLU11F, GLU55E, GLU55F, GLY10E, GLY10F, GLY70E, GLY70F, HIS75E, HIS75F, HIS84E, HIS84F, HIS8E, HIS8F, ILE102E, ILE102F, ILE104E, ILE104F, ILE31E, ILE31F, ILE44E, ILE44F, ILE6E, ILE6F, ILE71E, ILE71F, LEU112E, LEU112F, LEU90E, LEU90F, LYS115E, LYS115F, LYS50E, LYS50F, LYS74E, LYS74F, LYS88E, LYS88F, PHE101E, PHE101F, PHE12E, PHE12F, PHE49E, PHE49F, PHE53E, PHE53F, PHE54E, PHE54F, PHE7E, PHE7F, PHE86E, PHE86F, PRO5E, SER113E, SER113F, SER13E, SER13F, SER17E, SER17F, SER19E, SER19F, SER47F, SER73E, SER73F, SER78E, SER78F, THR106E, THR106F, THR56E, THR56F, THR81E, THR81F, THR83E, THR83F, THR85E, THR85F, THR91E, TRP21E, TRP21F, TRP76E, TRP76F, TRP99E, TRP99F, TYR52E, TYR52F, TYR79E, TYR79F, VAL109E, VAL109F, VAL111E, VAL111F, VAL14E, VAL14F, VAL22E, VAL22F, VAL42E, VAL42F, VAL48E, VAL48F, VAL87E, VAL87F