2IDE

crystal structure of the molybdenum cofactor biosynthesis protein c (ttha1789) from thermus theromophilus hb8

• Total interactions analyzed: 66
• Total true interactions: 37
• Strongest Interaction:
  • Chains: I-L
  • Int. Res.: 66
  • Norm. En. per Res.: -5.7093
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-22.0938	-22.0938	30	1	4	1609	0	6	6
A-C	0.0	16.636	-0.5182	16.1177	2	0	0	15	0	2	1
A-D	-98.4214	-57.2869	-228.807	-384.5153	72	22	1	9018	5	30	25
A-E	-66.7533	-53.1559	-219.708	-339.6172	68	24	1	8839	5	30	24
A-F	-106.7577	-21.8165	-480.145	-608.7192	180	28	16	22744	1	42	52
A-I	0.0	-9.8909	-29.4699	-39.3608	18	0	0	1131	0	16	13
A-L	0.0	0.0	-18.1983	-18.1983	16	0	0	807	0	4	5
B-C	-82.1544	-52.0786	-242.326	-376.559	69	16	1	9324	6	31	26
B-D	0.0	7.3738	-0.0527	7.3211	2	0	0	7	0	2	1
B-E	-88.8603	-22.8507	-504.748	-616.4591	180	22	17	23068	2	39	51
B-F	-81.2514	-68.1106	-213.815	-363.177	66	18	1	8833	5	29	25
C-D	-99.5902	-2.8713	-506.162	-608.6235	179	31	17	22990	0	38	51
C-E	0.0	0.0	-23.6657	-23.6657	32	0	4	1589	0	6	6
C-F	-83.4922	-36.2986	-213.778	-333.5689	67	14	1	8879	3	29	23
D-E	-39.9976	-13.0122	-187.691	-240.7007	64	9	1	8231	2	27	24
D-F	0.0	0.0	-25.6208	-25.6208	35	0	4	1550	0	6	7
D-H	0.0	6.6616	-27.1179	-20.4563	14	1	0	814	0	10	12
D-I	-13.7463	8.6059	-58.0153	-63.1557	41	3	0	2591	0	24	17
E-F	0.0	16.1819	-0.4899	15.6921	2	0	0	16	0	2	1
E-H	-21.3496	3.8789	-66.528	-83.9987	42	3	0	2712	0	24	17
E-I	0.0	0.0	-0.4767	-0.4767	3	0	0	79	0	2	2
E-L	0.0	-7.7196	-28.1309	-35.8505	17	4	0	1165	0	15	13
G-H	0.0	0.0	-24.2449	-24.2449	29	0	4	1568	0	6	6
G-I	0.0	14.5001	-0.3771	14.123	2	0	0	14	0	2	1
G-J	-79.8957	-56.8132	-232.308	-369.0169	67	17	1	9218	5	29	24
G-K	-90.0241	-54.2442	-218.177	-362.4453	68	11	1	8851	6	27	26
G-L	-74.4399	-18.4063	-492.166	-585.0122	180	25	17	22924	2	39	53
H-I	-64.8534	-31.2009	-204.508	-300.5623	63	17	1	8216	3	29	23
H-J	0.0	16.9958	-0.5622	16.4336	4	0	0	18	0	2	1
H-K	-94.0907	-22.6836	-510.317	-627.0913	184	27	17	22921	1	40	52
H-L	-59.2242	-54.0236	-202.375	-315.6228	68	7	1	8288	4	29	25
I-J	-87.7267	-12.5129	-499.931	-600.1706	181	30	17	22741	0	40	54
I-K	0.0	0.0	-20.6629	-20.6629	31	3	4	1595	0	6	6
I-L	-95.9535	-59.0147	-221.847	-376.8151	66	15	1	8859	4	30	24
J-K	-91.4491	-51.4553	-237.391	-380.2954	68	13	1	9151	5	30	23
J-L	0.0	0.0	-26.3158	-26.3158	28	0	4	1654	0	6	5
K-L	0.0	17.4397	-0.5999	16.8398	3	0	0	17	0	2	1

Interface residues

• A-B: ALA56A, ALA56B, ALA59A, ALA59B, ASP51A, ASP51B, GLN57A, GLN57B, GLU83A, GLY48B, GLY50A, GLY50B, ILE61A, ILE61B, LEU58A, LEU58B, LEU62A, LEU62B, LYS49A, LYS49B, LYS66A, LYS66B, MET127A, MET127B, THR123A, THR123B, VAL54A, VAL54B, VAL55A, VAL55B
• A-C: ASP69A, ASP69C
• A-D: ALA105A, ALA105D, ALA59D, ALA64D, ALA68A, ALA99D, ARG10A, ARG12A, ARG24D, ARG85D, ASP15A, ASP69A, ASP69D, ASP8A, ASP8A5, CB9.8277034.55798, CB9.98576-53.98797, CYS74A, GLN57D, GLU106A, GLU112D, GLU18A, GLU21A, GLU21D, GLU83D, GLU87D, GLU98D, GLY81D, GLY9A, HIS75A, ILE61D, ILE71A, LEU53D, LEU58D, LEU62D, LEU70A, LEU73A, LEU77A, LEU77D, LEU79D, LYS102D, LYS104A, LYS104D, LYS19A, LYS65D, LYS66A, LYS66D, MET13A, PHE23D, PRO11A, PRO20A, PRO72A, PRO76A, PRO78A, PRO78D, THR100D, THR103D, THR107A, THR17A, THR22A, THR22D, THR25D, THR67A, THR80D, VAL101D, VAL14A, VAL16A, VAL54D, VAL55D, VAL82D, VAL84D, VAL86D
• A-E: ALA105A, ALA105E, ALA59A, ALA64A, ALA68E, ALA99A, ARG10E, ARG12E, ARG24A, ARG85A, ASP15E, ASP69A, ASP69E, CYS74E, GLN57A, GLU106E, GLU112A, GLU18E, GLU21A, GLU21E, GLU83A, GLU87A, GLU98A, GLY81A, GLY9E, HIS75E, ILE61A, ILE71E, LEU53A, LEU58A, LEU62A, LEU70E, LEU73E, LEU77A, LEU77E, LEU79A, LYS102A, LYS104A, LYS104E, LYS19E, LYS65A, LYS66A, LYS66E, MET13E, PHE23A, PRO11E, PRO20E, PRO72E, PRO76A, PRO76E, PRO78A, PRO78E, THR100A, THR103A, THR107E, THR17E, THR22A, THR25A, THR67E, THR80A, VAL101A, VAL14E, VAL16E, VAL54A, VAL55A, VAL82A, VAL84A, VAL86A
• A-F: ALA113A, ALA113F, ALA116A, ALA116F, ALA118A, ALA118F, ALA120A, ALA120F, ALA121A, ALA121F, ALA130A, ALA130F, ALA146F, ALA26A, ALA26F, ALA28A, ALA28F, ALA30A, ALA30F, ALA56A, ALA56F, ALA59A, ALA59F, ALA63A, ALA63F, ALA64A, ALA64F, ALA68A, ALA68F, ARG10A, ARG10F, ARG12A, ARG12F, ARG141A, ARG141F, ARG154A, ARG154F, ARG155A, ARG155F, ARG24A, ASP126A, ASP126F, ASP15A, ASP15F, ASP51A, ASP51F, ASP69A, ASP69F, ASP8A, CYS117A, CYS117F, CYS74A, CYS74F, GLN139A, GLN139F, GLN57A, GLN57F, GLU110A, GLU110F, GLU112A, GLU112F, GLU152A, GLU152F, GLU29A, GLU29F, GLU33A, GLU33F, GLY108A, GLY108F, GLY134A, GLY134F, GLY147A, GLY148A, GLY148F, GLY151A, GLY151F, GLY45A, GLY45F, GLY46F, GLY48A, GLY48F, GLY50A, GLY50F, GLY60A, GLY60F, GLY9A, HIS144A, HIS144F, HIS75A, HIS75F, ILE137A, ILE137F, ILE71A, ILE71F, LEU122A, LEU122F, LEU128A, LEU128F, LEU135A, LEU135F, LEU142A, LEU142F, LEU143A, LEU143F, LEU58A, LEU58F, LEU62A, LEU62F, LEU70A, LEU70F, LEU73A, LEU73F, LYS129A, LYS129F, LYS133A, LYS133F, LYS145A, LYS145F, LYS44F, LYS49A, LYS49F, LYS66A, LYS66F, MET111A, MET111F, MET114A, MET114F, MET127A, MET127F, MET13A, MET13F, PHE31A, PHE31F, PRO11A, PRO11F, PRO52A, PRO52F, PRO72A, PRO72F, SER132A, SER132F, SER138A, SER138F, SER150A, SER150F, THR107A, THR107F, THR115A, THR115F, THR123A, THR123F, THR27F, THR35A, THR35F, THR67A, THR67F, TRP153A, TRP153F, TYR125A, TYR125F, VAL109A, VAL109F, VAL119A, VAL119F, VAL124A, VAL124F, VAL136A, VAL136F, VAL140A, VAL140F, VAL14A, VAL14F, VAL32A, VAL32F, VAL47A, VAL47F, VAL54A, VAL54F, VAL55A, VAL55F
• A-I: GLU106A, GLU106I, GLU18A, GLU18I, GLU21A, GLU21I, LYS149A, LYS149I, LYS19A, LYS19I, PRO20A, PRO20I, THR17A, THR17I, THR22A, THR22I, VAL16A, VAL16I
• A-L: ARG24A, GLU21A, GLU21L, GLY147L, GLY148A, GLY148L, LYS104A, LYS104L, LYS19A, LYS19L, PHE23A, PHE23L, PRO20A, PRO20L, THR22A, THR22L
• B-C: ALA105B, ALA105C, ALA59C, ALA64C, ALA68B, ALA99C, ARG10B, ARG12B, ARG24C, ARG85C, ASP15B, ASP69B, ASP69C, CYS74B, GLN57C, GLU106B, GLU112C, GLU18B, GLU21B, GLU21C, GLU83C, GLU87C, GLU98C, GLY81C, GLY9B, HIS75B, ILE61C, ILE71B, LEU53C, LEU58C, LEU62C, LEU70B, LEU73B, LEU77B, LEU77C, LEU79C, LYS102C, LYS104B, LYS104C, LYS19B, LYS65C, LYS66B, LYS66C, MET13B, PHE23C, PRO11B, PRO20B, PRO72B, PRO76B, PRO76C, PRO78B, PRO78C, THR100C, THR103C, THR107B, THR17B, THR22B, THR22C, THR25C, THR67B, THR80C, VAL101C, VAL14B, VAL16B, VAL54C, VAL55C, VAL82C, VAL84C, VAL86C
• B-D: ASP69B, ASP69D
• B-E: ALA113B, ALA113E, ALA116B, ALA116E, ALA118B, ALA118E, ALA120B, ALA120E, ALA121B, ALA121E, ALA130B, ALA130E, ALA26B, ALA26E, ALA28B, ALA28E, ALA30B, ALA30E, ALA56B, ALA56E, ALA59B, ALA59E, ALA63B, ALA63E, ALA64B, ALA64E, ALA68B, ALA68E, ARG10B, ARG10E, ARG12B, ARG12E, ARG141B, ARG141E, ARG154B, ARG154E, ARG155B, ARG155E, ARG24B, ARG24E, ASP126B, ASP126E, ASP15B, ASP15E, ASP51B, ASP51E, ASP69B, ASP69E, CYS117B, CYS117E, CYS74B, CYS74E, GLN139B, GLN139E, GLN57B, GLN57E, GLU110B, GLU110E, GLU112B, GLU112E, GLU152B, GLU29B, GLU29E, GLU33B, GLU33E, GLY108B, GLY108E, GLY134B, GLY134E, GLY148B, GLY151B, GLY151E, GLY45B, GLY45E, GLY46B, GLY46E, GLY48B, GLY48E, GLY50B, GLY50E, GLY60B, GLY60E, GLY9B, GLY9E, HIS144B, HIS144E, HIS75B, HIS75E, ILE137B, ILE137E, ILE71B, ILE71E, LEU122B, LEU122E, LEU128B, LEU128E, LEU135B, LEU135E, LEU142B, LEU142E, LEU143B, LEU143E, LEU58B, LEU58E, LEU62B, LEU62E, LEU70B, LEU70E, LEU73B, LEU73E, LYS129B, LYS129E, LYS133B, LYS133E, LYS145B, LYS145E, LYS149B, LYS44B, LYS44E, LYS49B, LYS49E, LYS66B, LYS66E, MET111B, MET111E, MET114B, MET114E, MET127B, MET127E, MET13B, MET13E, PHE31B, PHE31E, PRO11B, PRO11E, PRO52B, PRO52E, PRO72B, PRO72E, SER132B, SER132E, SER138B, SER138E, SER150B, SER150E, THR107B, THR107E, THR115B, THR115E, THR123B, THR123E, THR27B, THR35B, THR35E, THR67B, THR67E, TRP153B, TRP153E, TYR125B, TYR125E, VAL109B, VAL109E, VAL119B, VAL119E, VAL124B, VAL124E, VAL136B, VAL136E, VAL140B, VAL140E, VAL14B, VAL14E, VAL32B, VAL32E, VAL47B, VAL47E, VAL54B, VAL54E, VAL55B, VAL55E
• B-F: ALA105B, ALA105F, ALA59B, ALA64B, ALA68F, ALA99B, ARG10F, ARG12F, ARG24B, ARG85B, ASP15F, ASP69B, ASP69F, CYS74F, GLN57B, GLU106F, GLU112B, GLU18F, GLU21B, GLU21F, GLU83B, GLU87B, GLU98B, GLY81B, HIS75F, ILE61B, ILE71F, LEU53B, LEU58B, LEU62B, LEU70F, LEU73F, LEU77B, LEU77F, LEU79B, LYS102B, LYS104B, LYS19F, LYS65B, LYS66B, LYS66F, MET13F, PHE23B, PRO11F, PRO20F, PRO72F, PRO76F, PRO78B, PRO78F, THR100B, THR103B, THR107F, THR17F, THR22B, THR25B, THR67F, THR80B, VAL101B, VAL109B, VAL14F, VAL16F, VAL54B, VAL55B, VAL82B, VAL84B, VAL86B
• C-D: ALA113C, ALA113D, ALA116C, ALA116D, ALA118C, ALA118D, ALA120C, ALA120D, ALA121C, ALA121D, ALA130C, ALA130D, ALA146C, ALA26C, ALA26D, ALA28C, ALA28D, ALA30C, ALA30D, ALA56C, ALA56D, ALA59C, ALA59D, ALA63C, ALA63D, ALA64C, ALA64D, ALA68C, ALA68D, ARG10C, ARG10D, ARG12C, ARG12D, ARG141C, ARG141D, ARG154C, ARG154D, ARG155C, ARG155D, ASP126C, ASP126D, ASP15C, ASP51C, ASP51D, ASP69C, ASP69D, CYS117C, CYS117D, CYS74C, CYS74D, GLN139C, GLN139D, GLN57C, GLN57D, GLU110C, GLU110D, GLU112C, GLU112D, GLU152C, GLU152D, GLU29C, GLU29D, GLU33C, GLU33D, GLY108C, GLY108D, GLY134C, GLY134D, GLY148C, GLY148D, GLY151C, GLY151D, GLY45C, GLY45D, GLY46C, GLY46D, GLY48C, GLY48D, GLY50C, GLY50D, GLY60C, GLY60D, GLY9C, GLY9D, HIS144C, HIS144D, HIS75C, HIS75D, ILE137C, ILE137D, ILE71C, ILE71D, LEU122C, LEU122D, LEU128C, LEU128D, LEU135C, LEU135D, LEU142C, LEU142D, LEU143C, LEU143D, LEU58C, LEU58D, LEU62C, LEU62D, LEU70C, LEU70D, LEU73C, LEU73D, LYS129C, LYS129D, LYS133C, LYS133D, LYS145C, LYS145D, LYS149D, LYS44C, LYS44D, LYS49C, LYS49D, LYS66C, LYS66D, MET111C, MET111D, MET114C, MET114D, MET127C, MET127D, MET13C, MET13D, PHE31C, PHE31D, PRO11C, PRO11D, PRO52C, PRO52D, PRO72C, PRO72D, SER132C, SER132D, SER138C, SER138D, SER150C, SER150D, THR107C, THR107D, THR115C, THR115D, THR123C, THR123D, THR35C, THR35D, THR67C, THR67D, TRP153C, TRP153D, TYR125C, TYR125D, VAL109C, VAL109D, VAL119C, VAL119D, VAL124C, VAL124D, VAL136C, VAL136D, VAL140C, VAL140D, VAL14C, VAL14D, VAL32C, VAL32D, VAL47C, VAL47D, VAL54C, VAL54D, VAL55C, VAL55D
• C-E: ALA56C, ALA56E, ALA59C, ALA59E, ASP126E, ASP51C, ASP51E, GLN57C, GLN57E, GLU83C, GLY48E, GLY50C, GLY50E, ILE61C, ILE61E, LEU58C, LEU58E, LEU62C, LEU62E, LYS49C, LYS49E, LYS65C, LYS66C, LYS66E, MET127C, MET127E, THR123C, THR123E, VAL54C, VAL54E, VAL55C, VAL55E
• C-F: ALA105C, ALA105F, ALA59F, ALA64F, ALA68C, ALA99F, ARG10C, ARG12C, ARG24F, ARG85F, ASP15C, ASP69C, ASP69F, CYS74C, GLN57F, GLU106C, GLU112F, GLU18C, GLU21C, GLU21F, GLU83F, GLU98F, GLY81F, GLY9C, HIS75C, ILE61F, ILE71C, LEU53F, LEU58F, LEU62F, LEU70C, LEU73C, LEU77C, LEU77F, LEU79F, LYS102F, LYS104C, LYS104F, LYS19C, LYS65F, LYS66C, LYS66F, MET13C, PHE23F, PRO11C, PRO20C, PRO72C, PRO76C, PRO76F, PRO78C, PRO78F, THR100F, THR103F, THR107C, THR17C, THR22F, THR25F, THR67C, THR80F, VAL101F, VAL14C, VAL16C, VAL54F, VAL55F, VAL82F, VAL84F, VAL86F
• D-E: ALA105D, ALA59E, ALA64E, ALA68D, ALA99E, ARG10D, ARG12D, ARG24E, ARG85E, ASP15D, ASP69D, ASP69E, CYS74D, GLN57E, GLU106D, GLU112E, GLU18D, GLU21D, GLU21E, GLU83E, GLU87E, GLU98E, GLY81E, GLY9D, HIS75D, ILE61E, ILE71D, LEU53E, LEU58E, LEU62E, LEU70D, LEU73D, LEU77D, LEU77E, LEU79E, LYS102E, LYS104E, LYS19D, LYS65E, LYS66D, LYS66E, MET13D, PHE23E, PRO11D, PRO20D, PRO72D, PRO76D, PRO78D, PRO78E, THR100E, THR103E, THR107D, THR17D, THR25E, THR67D, THR80E, VAL101E, VAL14D, VAL16D, VAL54E, VAL55E, VAL82E, VAL84E, VAL86E
• D-F: ALA56D, ALA56F, ALA59D, ALA59F, ASP126F, ASP51D, ASP51F, GLN57D, GLN57F, GLU83D, GLU83F, GLY48D, GLY48F, GLY50D, GLY50F, GLY60F, ILE61D, ILE61F, LEU58D, LEU58F, LEU62D, LEU62F, LYS49D, LYS49F, LYS65D, LYS66D, LYS66F, MET127D, MET127F, THR123D, THR123F, VAL54D, VAL54F, VAL55D, VAL55F
• D-H: GLU106H, GLU18D, GLU18H, GLU21D, GLU21H, LYS149D, LYS149H, LYS19D, LYS19H, PRO20D, PRO20H, THR17D, THR17H, VAL16D
• D-I: ALA105D, ALA105I, ALA146D, ALA146I, ARG154I, ARG24D, ARG24I, GLU106D, GLU106I, GLU152D, GLU152I, GLU18D, GLU18I, GLU21D, GLU21I, GLY147D, GLY147I, GLY148D, GLY148I, GLY151D, GLY151I, LYS102D, LYS102I, LYS104D, LYS104I, LYS149D, LYS149I, LYS19D, LYS19I, PHE23D, PHE23I, PRO20D, PRO20I, SER150D, SER150I, THR103I, THR17D, THR22D, THR22I, THR25I, THR80D
• E-F: ASP69E, ASP69F
• E-H: ALA105E, ALA105H, ALA146E, ALA146H, ARG24E, ARG24H, GLU106E, GLU106H, GLU152E, GLU152H, GLU18E, GLU18H, GLU21E, GLU21H, GLY147E, GLY147H, GLY148E, GLY148H, GLY151E, GLY151H, HIS144E, LYS102E, LYS102H, LYS104E, LYS104H, LYS145H, LYS149E, LYS149H, LYS19E, LYS19H, PHE23E, PHE23H, PRO20E, PRO20H, SER150E, SER150H, THR103E, THR17H, THR22E, THR22H, THR25E, THR80H
• E-I: GLU21I, LYS104E, LYS104I
• E-L: GLU106E, GLU106L, GLU18E, GLU18L, GLU21E, GLU21L, LYS149E, LYS149L, LYS19E, LYS19L, PRO20E, PRO20L, THR17E, THR17L, THR22L, VAL16E, VAL16L
• G-H: ALA56G, ALA56H, ALA59G, ALA59H, ASP51G, ASP51H, GLN57G, GLN57H, GLY50G, GLY50H, GLY60H, ILE61G, ILE61H, LEU58G, LEU58H, LEU62G, LEU62H, LYS49G, LYS49H, LYS66G, LYS66H, MET127G, MET127H, THR123G, THR123H, VAL54G, VAL54H, VAL55G, VAL55H
• G-I: ASP69G, ASP69I
• G-J: ALA105G, ALA105J, ALA59J, ALA64J, ALA68G, ALA99J, ARG10G, ARG12G, ARG24J, ARG85J, ASP15G, ASP69G, ASP69J, CYS74G, GLN57J, GLU106G, GLU112J, GLU18G, GLU21G, GLU21J, GLU83J, GLU87J, GLU98J, GLY81J, GLY9G, HIS75G, ILE61J, ILE71G, LEU53J, LEU58J, LEU62J, LEU70G, LEU73G, LEU77G, LEU77J, LEU79J, LYS102J, LYS104J, LYS19G, LYS65J, LYS66G, LYS66J, MET13G, PHE23J, PRO11G, PRO20G, PRO72G, PRO76G, PRO76J, PRO78G, PRO78J, THR100J, THR103J, THR107G, THR17G, THR22J, THR25J, THR67G, THR80J, VAL101J, VAL14G, VAL16G, VAL54J, VAL55J, VAL82J, VAL84J, VAL86J
• G-K: ALA105G, ALA105K, ALA59G, ALA64G, ALA68K, ALA99G, ARG10K, ARG12K, ARG24G, ARG85G, ASP15K, ASP69G, ASP69K, CYS74K, GLN57G, GLU106K, GLU112G, GLU18K, GLU21G, GLU21K, GLU83G, GLU87G, GLU98G, GLY81G, GLY9K, HIS75K, ILE61G, ILE71K, LEU53G, LEU58G, LEU62G, LEU70K, LEU73K, LEU77G, LEU77K, LEU79G, LYS102G, LYS104G, LYS19K, LYS65G, LYS66G, LYS66K, MET13K, PHE23G, PRO11K, PRO20K, PRO72K, PRO76G, PRO76K, PRO78G, PRO78K, THR100G, THR103G, THR107K, THR17K, THR22G, THR22K, THR25G, THR67K, THR80G, VAL101G, VAL14K, VAL16K, VAL54G, VAL55G, VAL82G, VAL84G, VAL86G
• G-L: ALA113G, ALA113L, ALA116G, ALA116L, ALA118G, ALA118L, ALA120G, ALA120L, ALA121G, ALA121L, ALA130G, ALA130L, ALA146G, ALA146L, ALA26G, ALA26L, ALA28G, ALA28L, ALA30G, ALA30L, ALA56G, ALA56L, ALA59G, ALA59L, ALA63G, ALA63L, ALA64G, ALA64L, ALA68G, ALA68L, ARG10G, ARG10L, ARG12G, ARG12L, ARG141G, ARG141L, ARG154G, ARG154L, ARG155G, ARG155L, ASP126G, ASP126L, ASP15G, ASP15L, ASP51G, ASP51L, ASP69G, ASP69L, CYS117G, CYS117L, CYS74G, CYS74L, GLN139G, GLN139L, GLN57G, GLN57L, GLU110G, GLU110L, GLU112G, GLU112L, GLU152G, GLU152L, GLU156L, GLU29G, GLU29L, GLU33G, GLU33L, GLY108G, GLY108L, GLY134G, GLY134L, GLY148G, GLY151G, GLY151L, GLY45G, GLY45L, GLY46G, GLY46L, GLY48G, GLY48L, GLY50G, GLY50L, GLY60G, GLY60L, GLY9G, GLY9L, HIS144G, HIS144L, HIS75G, HIS75L, ILE137G, ILE137L, ILE71G, ILE71L, LEU122G, LEU122L, LEU128G, LEU135G, LEU135L, LEU142G, LEU142L, LEU143G, LEU143L, LEU58G, LEU58L, LEU62G, LEU62L, LEU70G, LEU70L, LEU73G, LEU73L, LYS129G, LYS129L, LYS133G, LYS133L, LYS145G, LYS145L, LYS149G, LYS149L, LYS44G, LYS44L, LYS49G, LYS49L, LYS66G, LYS66L, MET111G, MET111L, MET114G, MET114L, MET127G, MET127L, MET13G, MET13L, PHE31G, PHE31L, PRO11G, PRO11L, PRO52G, PRO52L, PRO72G, PRO72L, SER132G, SER132L, SER138G, SER138L, SER150G, SER150L, THR107G, THR107L, THR115G, THR115L, THR123G, THR123L, THR27L, THR67G, THR67L, TRP153G, TRP153L, TYR125G, TYR125L, VAL109G, VAL109L, VAL119G, VAL119L, VAL124G, VAL124L, VAL136G, VAL136L, VAL140G, VAL140L, VAL14G, VAL14L, VAL32G, VAL32L, VAL47G, VAL47L, VAL54G, VAL54L, VAL55G, VAL55L
• H-I: ALA105H, ALA59I, ALA64I, ALA68H, ALA99I, ARG10H, ARG12H, ARG24I, ARG85I, ASP15H, ASP69H, ASP69I, CYS74H, GLN57I, GLU106H, GLU112I, GLU18H, GLU21H, GLU83I, GLU98I, GLY81I, GLY9H, HIS75H, ILE61I, ILE71H, LEU53I, LEU58I, LEU62I, LEU70H, LEU73H, LEU77H, LEU77I, LEU79I, LYS102I, LYS104I, LYS19H, LYS65I, LYS66H, LYS66I, MET13H, PHE23I, PRO11H, PRO20H, PRO72H, PRO76H, PRO76I, PRO78H, PRO78I, THR100I, THR103I, THR107H, THR17H, THR25I, THR67H, THR80I, VAL101I, VAL14H, VAL16H, VAL54I, VAL55I, VAL82I, VAL84I, VAL86I
• H-J: ASP69H, ASP69J, LEU70H, LEU70J
• H-K: ALA113H, ALA113K, ALA116H, ALA116K, ALA118H, ALA118K, ALA120H, ALA120K, ALA121H, ALA121K, ALA130H, ALA130K, ALA146H, ALA146K, ALA26H, ALA26K, ALA28H, ALA28K, ALA30H, ALA30K, ALA56H, ALA56K, ALA59H, ALA59K, ALA63H, ALA63K, ALA64H, ALA64K, ALA68H, ALA68K, ARG10H, ARG10K, ARG12H, ARG12K, ARG141H, ARG141K, ARG154H, ARG154K, ARG155H, ARG155K, ARG24H, ARG24K, ARG94K, ASP126H, ASP126K, ASP15H, ASP15K, ASP51H, ASP51K, ASP69H, ASP69K, CYS117H, CYS117K, CYS74H, CYS74K, GLN139H, GLN139K, GLN57H, GLN57K, GLU110H, GLU110K, GLU112H, GLU112K, GLU152H, GLU152K, GLU156K, GLU29H, GLU29K, GLU33H, GLU33K, GLY108H, GLY108K, GLY134H, GLY134K, GLY148H, GLY151H, GLY151K, GLY45H, GLY45K, GLY46H, GLY46K, GLY48H, GLY48K, GLY50H, GLY50K, GLY60H, GLY60K, GLY9H, GLY9K, HIS144H, HIS144K, HIS75H, HIS75K, ILE137H, ILE137K, ILE71H, ILE71K, LEU122H, LEU122K, LEU128K, LEU135H, LEU135K, LEU142H, LEU142K, LEU143H, LEU143K, LEU58H, LEU58K, LEU62H, LEU62K, LEU70H, LEU70K, LEU73H, LEU73K, LYS129H, LYS129K, LYS133H, LYS133K, LYS145H, LYS145K, LYS149H, LYS19H, LYS44H, LYS44K, LYS49H, LYS49K, LYS66H, LYS66K, MET111H, MET111K, MET114H, MET114K, MET127H, MET127K, MET13H, MET13K, PHE31H, PHE31K, PRO11H, PRO11K, PRO52H, PRO52K, PRO72H, PRO72K, SER132H, SER132K, SER138H, SER138K, SER150H, SER150K, THR107H, THR107K, THR115H, THR115K, THR123H, THR123K, THR27H, THR35K, THR67H, THR67K, TRP153H, TRP153K, TYR125H, TYR125K, VAL109H, VAL109K, VAL119H, VAL119K, VAL124H, VAL124K, VAL136H, VAL136K, VAL140H, VAL140K, VAL14H, VAL14K, VAL32H, VAL32K, VAL47H, VAL47K, VAL54H, VAL54K, VAL55H, VAL55K
• H-L: ALA105H, ALA105L, ALA59H, ALA64H, ALA68L, ALA99H, ARG10L, ARG12L, ARG24H, ARG85H, ASP15L, ASP69H, ASP69L, CYS74L, GLN57H, GLU106L, GLU112H, GLU18L, GLU21H, GLU21L, GLU83H, GLU87H, GLU98H, GLY81H, GLY9L, HIS75L, ILE61H, ILE71L, LEU53H, LEU58H, LEU62H, LEU70L, LEU73L, LEU77H, LEU77L, LEU79H, LYS102H, LYS104H, LYS19L, LYS65H, LYS66H, LYS66L, MET13L, PHE23H, PRO11L, PRO20L, PRO72L, PRO76H, PRO76L, PRO78H, PRO78L, THR100H, THR103H, THR107L, THR17L, THR22H, THR25H, THR67H, THR67L, THR80H, VAL101H, VAL14L, VAL16L, VAL54H, VAL55H, VAL82H, VAL84H, VAL86H
• I-J: ALA113I, ALA113J, ALA116I, ALA116J, ALA118I, ALA118J, ALA120I, ALA120J, ALA121I, ALA121J, ALA130I, ALA130J, ALA146I, ALA146J, ALA26I, ALA26J, ALA28I, ALA28J, ALA30I, ALA30J, ALA56I, ALA56J, ALA59I, ALA59J, ALA63I, ALA63J, ALA64I, ALA64J, ALA68I, ALA68J, ARG10I, ARG10J, ARG12I, ARG12J, ARG141I, ARG141J, ARG154I, ARG154J, ARG155I, ARG155J, ARG24I, ARG24J, ASP126I, ASP126J, ASP15I, ASP15J, ASP51I, ASP51J, ASP69I, ASP69J, CYS117I, CYS117J, CYS74I, CYS74J, GLN139I, GLN139J, GLN57I, GLN57J, GLU110I, GLU110J, GLU112I, GLU112J, GLU152I, GLU152J, GLU156I, GLU29I, GLU29J, GLU33I, GLU33J, GLY108I, GLY108J, GLY134I, GLY134J, GLY148I, GLY148J, GLY151I, GLY151J, GLY45I, GLY45J, GLY46I, GLY48I, GLY48J, GLY50I, GLY50J, GLY60I, GLY60J, GLY9J, HIS144I, HIS144J, HIS75I, HIS75J, ILE137I, ILE137J, ILE71I, ILE71J, LEU122I, LEU122J, LEU128I, LEU128J, LEU135I, LEU135J, LEU142I, LEU142J, LEU143I, LEU143J, LEU58I, LEU58J, LEU62I, LEU62J, LEU70I, LEU70J, LEU73I, LEU73J, LYS129I, LYS129J, LYS133I, LYS133J, LYS145I, LYS145J, LYS149J, LYS44I, LYS49I, LYS49J, LYS66I, LYS66J, MET111I, MET111J, MET114I, MET114J, MET127I, MET127J, MET13I, MET13J, PHE31I, PHE31J, PRO11I, PRO11J, PRO52I, PRO52J, PRO72I, PRO72J, SER132I, SER132J, SER138I, SER138J, SER150I, SER150J, THR107I, THR107J, THR115I, THR115J, THR123I, THR123J, THR35I, THR35J, THR67I, THR67J, TRP153I, TRP153J, TYR125I, TYR125J, VAL109I, VAL109J, VAL119I, VAL119J, VAL124I, VAL124J, VAL136I, VAL136J, VAL140I, VAL140J, VAL14I, VAL14J, VAL32I, VAL32J, VAL47I, VAL47J, VAL54I, VAL54J, VAL55I, VAL55J
• I-K: ALA56I, ALA56K, ALA59I, ALA59K, ASP51I, ASP51K, GLN57I, GLN57K, GLU83K, GLY48I, GLY50I, GLY50K, GLY60K, ILE61I, ILE61K, LEU58I, LEU58K, LEU62I, LEU62K, LYS49I, LYS49K, LYS66I, LYS66K, MET127I, MET127K, THR123I, THR123K, VAL54I, VAL54K, VAL55I, VAL55K
• I-L: ALA105I, ALA105L, ALA59L, ALA64L, ALA68I, ALA99L, ARG10I, ARG12I, ARG24L, ARG85L, ASP15I, ASP69I, ASP69L, CYS74I, GLN57L, GLU106I, GLU112L, GLU18I, GLU21I, GLU21L, GLU83L, GLU87L, GLU98L, GLY81L, HIS75I, ILE61L, ILE71I, LEU53L, LEU58L, LEU62L, LEU70I, LEU73I, LEU77I, LEU77L, LEU79L, LYS102L, LYS104L, LYS19I, LYS65L, LYS66I, LYS66L, MET13I, PHE23L, PRO11I, PRO20I, PRO72I, PRO76I, PRO76L, PRO78I, PRO78L, THR100L, THR103L, THR107I, THR17I, THR22L, THR25L, THR67I, THR80L, VAL101L, VAL14I, VAL16I, VAL54L, VAL55L, VAL82L, VAL84L, VAL86L
• J-K: ALA105J, ALA105K, ALA59K, ALA64K, ALA68J, ALA99K, ARG10J, ARG12J, ARG24K, ARG85K, ASP15J, ASP69J, ASP69K, CYS74J, GLN57K, GLU106J, GLU112K, GLU18J, GLU21J, GLU21K, GLU83K, GLU87K, GLU98K, GLY81K, GLY9J, HIS75J, ILE61K, ILE71J, LEU53K, LEU58K, LEU62K, LEU70J, LEU73J, LEU77J, LEU77K, LEU79K, LYS102K, LYS104K, LYS19J, LYS65K, LYS66J, LYS66K, MET13J, PHE23K, PRO11J, PRO20J, PRO72J, PRO76J, PRO76K, PRO78J, PRO78K, THR100K, THR103K, THR107J, THR17J, THR22J, THR22K, THR25K, THR67J, THR80K, VAL101K, VAL14J, VAL16J, VAL54K, VAL55K, VAL82K, VAL84K, VAL86K
• J-L: ALA56J, ALA56L, ALA59J, ALA59L, ASP51J, ASP51L, GLN57J, GLN57L, GLY50J, GLY50L, ILE61J, ILE61L, LEU58J, LEU58L, LEU62J, LEU62L, LYS49J, LYS49L, LYS66J, LYS66L, MET127J, MET127L, THR123J, THR123L, VAL54J, VAL54L, VAL55J, VAL55L
• K-L: ASP69K, ASP69L, LEU70L