2HZM

structure of the mediator head subcomplex med18/20

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 154
  • Norm. En. per Res.: -4.0117
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-126.5252	-28.7374	-462.541	-617.8036	154	20	12	20115	3	13	10
A-C	0.0	0.0	-33.9984	-33.9984	34	0	7	1493	0	4	2
A-D	-24.2185	-1.6088	-154.468	-180.2953	85	6	4	6385	4	23	26
B-C	0.0	31.8022	-57.2189	-25.4167	54	1	4	2737	0	17	20
B-D	-26.0708	0.0	-123.856	-149.9268	88	3	1	6168	0	7	9
B-F	0.0	16.6236	-13.9834	2.6402	14	1	0	863	0	5	7
B-H	0.0	27.6327	-34.5907	-6.958	29	2	0	1391	1	9	9
C-D	-134.037	-14.2289	-418.511	-566.7769	144	31	10	18261	1	9	8
D-F	-16.7081	10.1837	-153.015	-159.5393	67	11	0	6693	0	12	13
D-G	0.0	0.0	-0.2157	-0.2157	6	0	0	24	0	1	9
E-F	-116.02	-22.8368	-430.88	-569.7368	143	27	8	18464	1	9	9
G-H	-95.0206	-17.03	-410.463	-522.5136	141	19	9	18207	1	8	9

Interface residues

• A-B: ALA186B, ALA194B, ALA77A, ALA82A, ALA83A, ALA84A, ALA85A, ALA90A, ARG261B, ARG63B, ARG67A, ASN114A, ASN195A, ASN197B, ASN205B, ASN258B, ASN35B, ASN44B, ASN48A, ASN62B, ASN75A, ASN94A, ASP105A, ASP170B, ASP192A, ASP199A, ASP48B, ASP74A, ASP86A, CYS161B, CYS198A, CYS38B, CYS44A, GLN167B, GLN3B, GLN4B, GLN68A, GLU102A, GLU159B, GLU187B, GLU196A, GLU231B, GLU50B, GLU69B, GLY190A, GLY195B, GLY206B, GLY208B, GLY219B, GLY95A, GLY99A, ILE104A, ILE107A, ILE115A, ILE168B, ILE171B, ILE185B, ILE189B, ILE190B, ILE197A, ILE229B, ILE46A, ILE64B, ILE72A, ILE87A, LEU108A, LEU112A, LEU166B, LEU189A, LEU191B, LEU203B, LEU207B, LEU32B, LEU33B, LEU37B, LEU49A, LEU66B, LEU71A, LEU91A, LYS111A, LYS196B, LYS221B, LYS254B, LYS42B, LYS47A, LYS55A, LYS65B, LYS68B, LYS73A, MET204B, MET57A, MET78A, PHE222B, PHE223B, PHE72B, PHE93A, PRO101A, PRO163B, PRO191A, PRO31B, PRO43B, PRO61B, PRO88A, PRO89A, SER103A, SER110A, SER113A, SER160B, SER162B, SER165B, SER169B, SER188A, SER192B, SER193B, SER194A, SER198B, SER199B, SER202B, SER260B, SER36B, SER45A, SER46B, SER54A, SER67B, SER76A, SER96A, SER97A, THR106A, THR184B, THR188B, THR193A, THR217B, THR69A, THR80A, THR81A, THR98A, TRP116A, TRP164B, TYR202A, TYR209B, TYR215B, TYR256B, TYR34B, TYR47B, VAL100A, VAL200B, VAL220B, VAL259B, VAL2B, VAL49B, VAL70A, VAL70B, VAL79A, VAL92A
• A-C: ALA82A, ALA82C, ALA83A, ALA83C, ALA84A, ALA84C, ALA85A, ALA85C, ALA90A, ALA90C, ARG67A, ARG67C, ASN94A, ASN94C, ASP86A, ASP86C, GLY99A, GLY99C, HIS65A, HIS65C, ILE87A, ILE87C, PHE93A, PHE93C, PRO101A, PRO101C, PRO89A, PRO89C, THR98A, THR98C, VAL100A, VAL100C, VAL92A, VAL92C
• A-D: ALA157A, ALA201A, ALA83A, ALA84A, ALA85A, ALA90A, ARG138A, ARG261D, ARG267D, ARG32A, ARG67A, ASN195A, ASN258D, ASN269D, ASN29D, ASN94A, ASP158A, ASP199A, ASP264D, ASP266D, ASP33A, ASP86A, CB7.89397-15.72611, CB9.43321-9.96087, CYS198A, GLN156A, GLN3D, GLN68A, GLU154A, GLU159A, GLU196A, GLY134A, GLY227D, GLY262D, GLY66A, HIS226D, HIS63A, HIS64A, HIS65A, ILE131A, ILE197A, ILE229D, ILE257D, ILE265D, ILE268D, ILE37A, ILE60A, ILE87A, LEU135A, LEU155A, LEU200A, LEU228D, LEU32D, LEU33D, LEU91A, LYS221D, LYS225D, LYS3A, LYS3A9, MET224D, PHE222D, PHE223D, PHE62A, PHE93A, PRO30D, PRO88A, PRO89A, SER194A, SER260D, SER36A, SER4A, THR129A, THR136A, THR263D, THR61A, THR81A, TRP35A, TYR204A, TYR256D, VAL137A, VAL259D, VAL2D, VAL70A, VAL79A, VAL92A
• B-C: ALA157C, ALA83C, ALA84C, ALA85C, ALA90C, ARG138C, ARG261B, ARG267B, ASN195C, ASN258B, ASN269B, ASN29B, ASN94C, ASP158C, ASP264B, ASP266B, ASP33C, ASP86C, GLN156C, GLN3B, GLN68C, GLU159C, GLU196C, GLY227B, GLY262B, GLY66C, HIS226B, HIS64C, HIS65C, ILE197C, ILE229B, ILE257B, ILE265B, ILE87C, LEU228B, LEU32B, LEU33B, LEU91C, LYS221B, LYS225B, LYS3C, MET224B, PHE222B, PHE223B, PHE93C, PRO30B, PRO88C, PRO89C, SER260B, THR263B, TYR256B, VAL259B, VAL2B, VAL92C
• B-D: ARG267B, ARG267D, ARG88B, ARG88D, ASN29B, ASN29D, ASN35B, ASN35D, ASN86B, ASN86D, ASP17D, GLU69B, GLU69D, GLU78B, GLY219B, GLY219D, GLY227B, GLY227D, GLY28B, GLY28D, HIS226B, HIS226D, ILE20B, ILE20D, ILE26B, ILE26D, ILE76B, ILE76D, ILE89B, ILE89D, LEU191B, LEU191D, LEU32B, LEU32D, LEU33B, LEU33D, LEU75B, LEU75D, LEU85B, LEU85D, LYS221B, LYS221D, LYS225B, LYS225D, LYS68B, LYS68D, LYS83B, LYS83D, MET224B, MET224D, PHE222B, PHE222D, PHE223B, PHE223D, PHE72B, PHE72D, PHE87B, PHE87D, PRO163B, PRO163D, PRO30B, PRO30D, PRO31B, PRO31D, PRO71B, PRO71D, PRO84B, PRO84D, SER162B, SER162D, SER21B, SER21D, SER27B, SER27D, SER73B, SER73D, THR24B, THR24D, THR25B, THR25D, TYR34B, TYR34D, TYR74B, TYR74D, VAL220B, VAL220D, VAL70B, VAL70D
• B-F: ARG88F, ASP77B, ASP82F, GLU78B, ILE76B, LEU85F, LYS83B, LYS83F, PHE87F, PRO84B, PRO84F, SER73B, THR79F, TYR74B
• B-H: ARG88H, ASP14B, ASP77H, ASP82H, GLN283B, GLU281B, GLU287B, GLU78H, GLY12B, GLY284B, ILE11B, ILE286B, ILE76H, LEU282B, LEU288B, LEU75H, LEU85H, LYS279B, LYS280B, MET81H, PHE72H, PRO71H, SER10B, SER289B, SER73H, THR79H, TYR285B, TYR74H, VAL70H
• C-D: ALA186D, ALA194D, ALA77C, ALA82C, ALA83C, ALA84C, ALA85C, ALA90C, ARG261D, ARG63D, ARG67C, ASN114C, ASN195C, ASN197D, ASN205D, ASN258D, ASN35D, ASN44D, ASN62D, ASN75C, ASN94C, ASP105C, ASP170D, ASP199C, ASP74C, ASP86C, CYS161D, CYS198C, CYS38D, CYS44C, GLN167D, GLN3D, GLN4D, GLN68C, GLU102C, GLU187D, GLU196C, GLU231D, GLU69D, GLY195D, GLY206D, GLY208D, GLY219D, GLY95C, GLY99C, ILE104C, ILE107C, ILE115C, ILE168D, ILE171D, ILE185D, ILE189D, ILE190D, ILE197C, ILE218D, ILE229D, ILE46C, ILE64D, ILE72C, ILE87C, LEU108C, LEU112C, LEU166D, LEU189C, LEU191D, LEU203D, LEU207D, LEU32D, LEU33D, LEU37D, LEU66D, LEU71C, LEU75D, LEU91C, LYS111C, LYS196D, LYS221D, LYS254D, LYS42D, LYS65D, LYS68D, LYS73C, MET204D, MET57C, MET78C, PHE222D, PHE223D, PHE72D, PHE93C, PRO101C, PRO163D, PRO172D, PRO31D, PRO43D, PRO61D, PRO71D, PRO88C, PRO89C, SER103C, SER110C, SER113C, SER160D, SER162D, SER165D, SER169D, SER188C, SER192D, SER193D, SER198D, SER199D, SER202D, SER260D, SER36D, SER45C, SER46D, SER54C, SER67D, SER76C, SER96C, SER97C, THR106C, THR184D, THR188D, THR217D, THR69C, THR80C, THR81C, THR98C, TRP116C, TRP164D, TYR202C, TYR209D, TYR256D, TYR34D, TYR47D, VAL100C, VAL200D, VAL220D, VAL259D, VAL2D, VAL70C, VAL70D, VAL79C, VAL92C
• D-F: ALA103F, ARG88F, ASN101F, ASN243F, ASN277D, ASN86F, ASN95F, ASP13F, ASP14D, ASP14F, ASP17D, ASP17F, ASP77F, ASP82F, ASP96F, GLN245F, GLN283D, GLU281D, GLU287D, GLU78F, GLY12D, GLY15D, GLY284D, GLY28D, ILE11D, ILE20D, ILE26D, ILE286D, ILE76F, ILE89F, ILE98F, LEU100F, LEU18D, LEU19D, LEU23D, LEU278D, LEU282D, LEU288D, LEU75F, LEU90F, LYS279D, LYS280D, LYS83F, LYS91F, LYS97F, MET104F, MET276D, MET80F, MET81F, PHE87F, PHE93F, PRO99F, SER21D, SER27D, SER92F, THR22D, THR24D, THR25D, THR273D, THR79F, THR94F, TRP236F, TYR102F, TYR16F, TYR285D, TYR74F, VAL274D
• D-G: ALA241D, GLU162G, GLU164G, GLU240D, GLY161G, GLY242D
• E-F: ALA186F, ALA194F, ALA77E, ALA82E, ALA83E, ALA84E, ALA85E, ALA90E, ARG261F, ARG63F, ARG67E, ASN114E, ASN195E, ASN197F, ASN205F, ASN258F, ASN35F, ASN44F, ASN48E, ASN62F, ASN75E, ASN94E, ASP105E, ASP170F, ASP199E, ASP74E, ASP86E, CYS161F, CYS198E, CYS38F, CYS44E, GLN167F, GLN3F, GLN4F, GLN68E, GLU102E, GLU187F, GLU196E, GLU231F, GLU69F, GLY195F, GLY206F, GLY208F, GLY219F, GLY95E, GLY99E, ILE104E, ILE107E, ILE115E, ILE168F, ILE171F, ILE185F, ILE189F, ILE190F, ILE197E, ILE218F, ILE229F, ILE46E, ILE64F, ILE72E, ILE87E, LEU108E, LEU112E, LEU166F, LEU191F, LEU203F, LEU207F, LEU32F, LEU33F, LEU37F, LEU66F, LEU71E, LEU91E, LYS111E, LYS196F, LYS221F, LYS254F, LYS42F, LYS47E, LYS55E, LYS65F, LYS68F, LYS73E, MET204F, MET57E, MET78E, PHE222F, PHE223F, PHE72F, PHE93E, PRO101E, PRO163F, PRO31F, PRO43F, PRO61F, PRO88E, PRO89E, SER103E, SER110E, SER113E, SER160F, SER162F, SER165F, SER169F, SER188E, SER192F, SER193F, SER198F, SER199F, SER202F, SER260F, SER36F, SER45E, SER46F, SER67F, SER76E, SER96E, SER97E, THR106E, THR184F, THR188F, THR217F, THR69E, THR80E, THR81E, THR98E, TRP116E, TRP164F, TYR202E, TYR209F, TYR215F, TYR256F, TYR34F, TYR47F, VAL100E, VAL200F, VAL220F, VAL259F, VAL2F, VAL70E, VAL70F, VAL79E, VAL92E
• G-H: ALA186H, ALA194H, ALA77G, ALA82G, ALA83G, ALA84G, ALA85G, ALA90G, ARG261H, ARG63H, ARG67G, ASN114G, ASN195G, ASN197H, ASN205H, ASN258H, ASN35H, ASN44H, ASN62H, ASN75G, ASN94G, ASP105G, ASP170H, ASP199G, ASP74G, ASP86G, CYS161H, CYS198G, CYS38H, CYS44G, GLN167H, GLN3H, GLN4H, GLN68G, GLU102G, GLU187H, GLU196G, GLU231H, GLU69H, GLY195H, GLY206H, GLY208H, GLY219H, GLY95G, GLY99G, ILE104G, ILE107G, ILE115G, ILE168H, ILE171H, ILE185H, ILE189H, ILE190H, ILE197G, ILE229H, ILE46G, ILE64H, ILE72G, ILE87G, LEU108G, LEU112G, LEU166H, LEU189G, LEU191H, LEU203H, LEU207H, LEU216H, LEU32H, LEU33H, LEU37H, LEU66H, LEU71G, LEU91G, LYS111G, LYS196H, LYS221H, LYS254H, LYS42H, LYS55G, LYS65H, LYS68H, LYS73G, MET204H, MET57G, MET78G, PHE222H, PHE223H, PHE72H, PHE93G, PRO101G, PRO163H, PRO31H, PRO43H, PRO61H, PRO88G, PRO89G, SER103G, SER110G, SER113G, SER160H, SER162H, SER165H, SER169H, SER188G, SER192H, SER193H, SER198H, SER199H, SER202H, SER260H, SER36H, SER45G, SER46H, SER67H, SER76G, SER96G, SER97G, THR106G, THR184H, THR188H, THR217H, THR69G, THR80G, THR81G, THR98G, TRP116G, TRP164H, TYR202G, TYR209H, TYR256H, TYR34H, TYR47H, VAL100G, VAL200H, VAL220H, VAL259H, VAL2H, VAL70G, VAL70H, VAL79G, VAL92G