2HYB

crystal structure of hexameric dsrefh

• Total interactions analyzed: 153
• Total true interactions: 45
• Strongest Interaction:
  • Chains: P-R
  • Int. Res.: 75
  • Norm. En. per Res.: -4.0347
• Hub Node: G(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-34.4882	-43.1705	-201.805	-279.4637	77	17	12	8841	6	15	17
A-C	-21.0996	-58.6084	-198.556	-278.264	75	4	10	7912	5	21	17
A-D	-56.1598	-56.6487	-299.066	-411.8745	108	8	4	11904	2	38	46
A-E	-32.6234	-17.3786	-98.3523	-148.3543	43	7	1	3693	1	10	10
A-F	0.0	0.0	-0.4527	-0.4527	5	0	0	45	0	2	2
B-C	-30.1942	-13.7617	-161.628	-205.5839	70	8	2	6639	1	18	18
B-D	-32.3233	-18.0602	-95.8904	-146.2739	40	7	1	3608	2	10	10
B-F	-31.4634	-14.7815	-202.631	-248.8759	75	5	5	8191	2	30	32
C-D	0.0	0.0	-0.406	-0.406	5	0	0	42	0	2	2
C-E	-35.9014	-11.9298	-216.201	-264.0323	75	7	5	8371	2	30	32
C-F	0.0	13.1734	-48.7936	-35.6202	25	2	0	1714	0	12	12
D-E	-36.7305	-44.3183	-200.801	-281.8498	75	9	11	8446	6	15	17
D-F	-18.6908	-56.4341	-214.804	-289.9289	77	7	11	8134	5	21	17
E-F	-24.3008	-14.0552	-161.014	-199.37	70	13	3	6649	1	18	18
G-H	-38.8545	-43.0063	-198.364	-280.2249	74	7	9	8376	6	15	17
G-I	-17.1295	-57.6641	-208.668	-283.4615	75	2	11	8027	5	21	17
G-J	-60.3583	-57.2507	-297.729	-415.338	110	9	4	11922	3	38	46
G-K	-33.9254	-17.5847	-90.7259	-142.236	42	8	1	3650	1	10	10
G-L	0.0	0.0	-0.3583	-0.3583	5	0	0	39	0	2	2
G-P	0.0	0.0	-1.2635	-1.2635	12	0	0	154	0	6	5
H-I	-32.5013	-13.4854	-154.941	-200.9277	70	9	2	6447	1	17	18
H-J	-33.1446	-17.8028	-89.8238	-140.7712	41	11	1	3642	1	10	10
H-L	-32.9485	-18.0719	-221.228	-272.2484	75	5	5	8528	2	30	33
I-J	0.0	0.0	-0.4909	-0.4909	5	0	0	44	0	2	2
I-K	-27.0782	-16.0342	-216.409	-259.5214	75	7	5	8347	2	30	33
I-L	0.0	12.3786	-44.0769	-31.6983	23	1	0	1597	0	12	12
J-K	-22.1876	-35.3944	-211.912	-269.494	77	4	11	8577	7	15	16
J-L	-38.6954	-59.0888	-211.002	-308.7862	77	8	11	8191	5	21	17
J-P	-7.1081	-39.834	-9.3174	-56.2594	20	2	0	621	3	3	5
J-Q	0.0	-17.5947	-43.8012	-61.3959	25	1	0	1564	0	7	11
K-L	-19.8614	-8.0472	-163.494	-191.4026	68	5	2	6420	1	17	18
M-N	-26.4236	-44.5432	-205.514	-276.4807	77	15	11	8770	6	15	17
M-O	-20.8482	-59.1617	-205.515	-285.5249	75	5	11	8006	5	21	17
M-P	-57.7722	-57.4089	-295.933	-411.114	110	4	5	11884	2	38	46
M-Q	-38.4844	-18.9732	-94.142	-151.5995	42	3	1	3594	1	10	10
M-R	0.0	0.0	-0.4389	-0.4389	5	0	0	42	0	2	2
N-O	-19.3017	-16.0305	-161.959	-197.2912	70	13	2	6696	1	18	18
N-P	-29.1342	-17.1659	-92.9061	-139.2062	41	6	1	3577	1	10	10
N-R	-34.6825	-15.9742	-211.7	-262.3567	75	7	5	8325	2	29	32
O-P	0.0	0.0	-0.3536	-0.3536	5	0	0	38	0	2	2
O-Q	-36.0564	-14.5868	-213.567	-264.2103	76	9	5	8334	1	30	33
O-R	0.0	10.717	-47.4006	-36.6836	24	1	0	1690	0	12	12
P-Q	-30.5339	-46.5988	-212.483	-289.6157	77	5	10	8615	7	15	17
P-R	-36.162	-61.6473	-204.79	-302.5993	75	6	11	8137	5	21	17
Q-R	-26.4181	-12.212	-163.861	-202.4911	70	11	2	6593	1	18	19

Interface residues

• A-B: ALA118A, ALA119A, ALA122A, ALA222B, ALA225B, ALA233B, ALA234B, ALA332B, ALA4A, ALA80A, ALA81A, ALA82A, ARG124A, ARG213B, ARG36A, ARG84A, ARG85A, ASN8A, ASP123A, ASP130A, ASP236B, ASP331B, ASP42A, CYS78A, GLN114A, GLN121A, GLN237B, GLN6A, GLU117A, GLU224B, GLU227B, GLU9A, GLY10A, GLY111A, GLY113A, GLY129A, GLY232B, GLY43A, HIS14A, HIS41A, ILE120A, ILE220B, ILE231B, LEU112A, LEU115A, LEU125A, LEU211B, LEU226B, LEU230B, LYS206B, LYS214B, LYS263B, LYS2A, MET209B, MET262B, PHE128A, PHE208B, PHE235B, PHE265B, PHE334B, PHE336B, PHE38A, SER335B, THR219B, TRP223B, TYR210B, TYR221B, TYR40A, VAL116A, VAL126A, VAL127A, VAL205B, VAL228B, VAL229B, VAL239B, VAL333B, VAL44A
• A-C: ALA16A, ALA20A, ALA24A, ALA26A, ALA27A, ALA468C, ALA486C, ALA500C, ARG124A, ARG414C, ARG469C, ASN408C, ASN8A, ASP123A, ASP130A, ASP18A, ASP435C, ASP465C, ASP484C, ASP490C, ASP496C, CYS495C, GLN15A, GLN22A, GLN499C, GLN6A, GLU29A, GLU413C, GLU434C, GLU494C, GLU9A, GLY129A, GLY31A, GLY436C, GLY487C, HIS14A, HIS32A, HIS41A, ILE34A, ILE403C, ILE437C, LEU125A, LEU28A, LEU404C, LEU431C, LEU462C, LEU491C, LEU502C, LEU5A, LYS25A, LYS2A, LYS30A, LYS409C, MET1A, PHE128A, PHE23A, PHE3A, PHE433C, PHE488C, PRO464C, SER17A, SER19A, SER402C, SER416C, THR406C, THR492C, THR493C, THR497C, TRP501C, TYR21A, TYR485C, VAL126A, VAL127A, VAL489C, VAL498C
• A-D: ALA100A, ALA1080D, ALA1081D, ALA1082D, ALA1093D, ALA1100D, ALA80A, ALA81A, ALA82A, ALA93A, ARG1049D, ARG1058D, ARG1084D, ARG1085D, ARG1095D, ARG49A, ARG58A, ARG84A, ARG85A, ARG95A, ASN1008D, ASN102A, ASN1045D, ASN1046D, ASN1062D, ASN1096D, ASN1102D, ASN45A, ASN46A, ASN62A, ASN8A, ASN96A, ASP1042D, ASP1056D, ASP1057D, ASP1089D, ASP1099D, ASP1130D, ASP130A, ASP42A, ASP57A, ASP89A, ASP99A, GLN1013D, GLN1055D, GLN1083D, GLN13A, GLN55A, GLN83A, GLU1009D, GLU1092D, GLU92A, GLU9A, GLY1010D, GLY1043D, GLY1086D, GLY1097D, GLY10A, GLY1129D, GLY129A, GLY43A, GLY86A, GLY97A, HIS1014D, HIS1041D, HIS104A, HIS1059D, HIS14A, HIS41A, HIS59A, ILE103A, ILE1060D, ILE1087D, ILE1103D, ILE60A, ILE87A, LEU1050D, LEU50A, LYS1098D, LYS98A, PRO1011D, PRO1053D, PRO1054D, PRO105A, PRO1105D, PRO11A, PRO53A, PRO54A, THR101A, THR1048D, THR1051D, THR1052D, THR1101D, THR48A, THR51A, THR52A, TYR1012D, TYR1040D, TYR12A, TYR40A, VAL1044D, VAL1061D, VAL1079D, VAL1088D, VAL44A, VAL61A, VAL79A, VAL88A
• A-E: ALA1222E, ALA16A, ARG58A, ARG63A, ASN1264E, ASP130A, ASP18A, ASP56A, ASP57A, GLN13A, GLN15A, GLN22A, GLN55A, GLU1224E, GLU1227E, GLU9A, GLY1218E, GLY1259E, GLY1261E, GLY129A, HIS14A, HIS59A, ILE1220E, ILE1260E, ILE60A, LYS1214E, LYS1258E, LYS1263E, LYS25A, MET1262E, PHE1265E, PHE1336E, PRO11A, PRO1216E, PRO54A, SER19A, THR1219E, THR1257E, TRP1223E, TYR1217E, TYR1221E, TYR12A, TYR21A
• A-F: ARG1414F, ASP130A, GLU1413F, HIS14A, LYS1409F
• B-C: ALA289B, ALA321B, ALA332B, ALA424C, ALA428C, ALA500C, ARG213B, ARG284B, ARG290B, ARG322B, ARG414C, ASN328B, ASN408C, ASN415C, ASP245B, ASP246B, ASP283B, ASP285B, ASP319B, ASP331B, ASP496C, CYS420C, GLN499C, GLU288B, GLU325B, GLU329B, GLU418C, GLU426C, GLY247B, GLY427C, HIS405C, ILE318B, ILE403C, LEU211B, LEU242B, LEU244B, LEU326B, LEU404C, LEU417C, LEU421C, LEU502C, LYS207B, LYS214B, LYS409C, LYS422C, MET209B, MET327B, PHE208B, PHE334B, PHE336B, PHE423C, SER286B, SER320B, SER324B, SER330B, SER335B, SER402C, SER416C, SER419C, SER429C, THR219B, THR406C, THR425C, THR497C, TRP501C, TYR221B, VAL323B, VAL333B, VAL407C, VAL498C
• B-D: ALA1016D, ARG1058D, ARG1063D, ASN264B, ASP1018D, ASP1056D, ASP1057D, ASP1130D, GLN1013D, GLN1015D, GLN1022D, GLN1055D, GLU1009D, GLU224B, GLU227B, GLY218B, GLY259B, GLY261B, HIS1014D, HIS1059D, ILE1060D, ILE220B, ILE260B, LYS1025D, LYS214B, LYS258B, LYS263B, MET262B, PHE265B, PHE336B, PRO1011D, PRO1054D, PRO216B, SER1019D, THR219B, TRP223B, TYR1012D, TYR1021D, TYR217B, TYR221B
• B-F: ALA1439F, ALA1442F, ALA1468F, ALA215B, ALA289B, ARG1414F, ARG1445F, ARG1469F, ARG1475F, ARG213B, ARG253B, ARG290B, ASN1408F, ASN264B, ASP1435F, ASP1465F, ASP1484F, ASP245B, ASP246B, ASP256B, ASP285B, ASP295B, ASP296B, GLN250B, GLN255B, GLU1413F, GLU1434F, GLU1447F, GLU288B, GLY1436F, GLY1443F, GLY1463F, GLY1470F, GLY218B, GLY247B, GLY254B, GLY259B, GLY261B, GLY291B, ILE1437F, ILE260B, LEU1441F, LEU1462F, LEU1466F, LEU287B, LEU292B, LEU297B, LYS1409F, LYS1467F, LYS214B, LYS258B, MET262B, PHE1412F, PHE1433F, PHE1471F, PHE265B, PRO1411F, PRO1464F, PRO216B, SER1410F, SER1472F, SER266B, SER286B, THR1444F, THR219B, THR252B, THR257B, THR293B, TYR1438F, TYR1485F, TYR217B, TYR221B, TYR249B, VAL1446F, VAL248B
• C-D: ARG414C, ASP1130D, GLU413C, HIS1014D, LYS409C
• C-E: ALA1215E, ALA1289E, ALA439C, ALA442C, ALA468C, ARG1213E, ARG1253E, ARG1290E, ARG414C, ARG445C, ARG469C, ARG475C, ASN1264E, ASN408C, ASP1245E, ASP1246E, ASP1256E, ASP1285E, ASP1295E, ASP1296E, ASP435C, ASP465C, ASP484C, GLN1250E, GLN1255E, GLU1288E, GLU413C, GLU434C, GLU447C, GLY1218E, GLY1254E, GLY1259E, GLY1261E, GLY1291E, GLY436C, GLY443C, GLY463C, GLY470C, ILE1260E, ILE437C, LEU1287E, LEU1292E, LEU1297E, LEU441C, LEU462C, LEU466C, LYS1214E, LYS1258E, LYS1263E, LYS409C, LYS467C, MET1262E, PHE1265E, PHE412C, PHE433C, PHE471C, PRO1216E, PRO411C, PRO464C, SER1266E, SER1286E, SER410C, SER472C, THR1219E, THR1252E, THR1257E, THR1293E, THR444C, TYR1217E, TYR1221E, TYR1249E, TYR438C, TYR485C, VAL1248E, VAL446C
• C-F: ARG1414F, ARG1445F, ARG414C, ARG445C, ASN1415F, ASN415C, GLU1413F, GLU1418F, GLU413C, GLU418C, LEU1502F, LEU502C, LYS1409F, LYS409C, LYS422C, PHE1412F, PHE412C, PRO1411F, PRO411C, SER1410F, SER1416F, SER1419F, SER410C, SER416C, SER419C
• D-E: ALA1004D, ALA1016D, ALA1080D, ALA1081D, ALA1082D, ALA1118D, ALA1119D, ALA1122D, ALA1222E, ALA1225E, ALA1233E, ALA1234E, ALA1332E, ARG1084D, ARG1085D, ARG1124D, ARG1213E, ASN1008D, ASP1042D, ASP1123D, ASP1130D, ASP1236E, ASP1331E, CYS1078D, GLN1006D, GLN1114D, GLN1121D, GLN1237E, GLU1009D, GLU1117D, GLU1224E, GLU1227E, GLY1010D, GLY1043D, GLY1111D, GLY1113D, GLY1129D, GLY1232E, HIS1014D, HIS1041D, ILE1120D, ILE1220E, ILE1231E, LEU1112D, LEU1115D, LEU1125D, LEU1226E, LEU1230E, LYS1002D, LYS1206E, LYS1214E, LYS1263E, MET1209E, MET1262E, PHE1038D, PHE1128D, PHE1208E, PHE1235E, PHE1265E, PHE1334E, PHE1336E, SER1335E, THR1219E, TRP1223E, TYR1040D, TYR1210E, TYR1221E, VAL1116D, VAL1126D, VAL1127D, VAL1205E, VAL1228E, VAL1229E, VAL1239E, VAL1333E
• D-F: ALA1004D, ALA1016D, ALA1020D, ALA1024D, ALA1026D, ALA1027D, ALA1468F, ALA1486F, ALA1500F, ARG1063D, ARG1124D, ARG1414F, ARG1469F, ASN1008D, ASN1408F, ASP1018D, ASP1123D, ASP1130D, ASP1435F, ASP1465F, ASP1484F, ASP1490F, ASP1496F, CYS1495F, GLN1006D, GLN1015D, GLN1022D, GLN1499F, GLU1009D, GLU1029D, GLU1413F, GLU1434F, GLU1494F, GLY1031D, GLY1129D, GLY1436F, GLY1487F, HIS1014D, HIS1032D, HIS1041D, ILE1034D, ILE1403F, ILE1437F, LEU1005D, LEU1028D, LEU1125D, LEU1404F, LEU1431F, LEU1462F, LEU1491F, LEU1502F, LYS1002D, LYS1025D, LYS1030D, LYS1409F, MET1001D, PHE1003D, PHE1023D, PHE1128D, PHE1433F, PHE1488F, PRO1464F, SER1017D, SER1019D, SER1402F, SER1416F, THR1406F, THR1492F, THR1493F, THR1497F, TRP1501F, TYR1021D, TYR1485F, VAL1126D, VAL1127D, VAL1489F, VAL1498F
• E-F: ALA1289E, ALA1321E, ALA1332E, ALA1424F, ALA1428F, ALA1500F, ARG1213E, ARG1284E, ARG1290E, ARG1322E, ARG1414F, ASN1328E, ASN1408F, ASN1415F, ASP1245E, ASP1246E, ASP1283E, ASP1285E, ASP1319E, ASP1331E, ASP1496F, CYS1420F, GLN1499F, GLU1288E, GLU1325E, GLU1329E, GLU1418F, GLU1426F, GLY1247E, GLY1427F, HIS1405F, ILE1318E, ILE1403F, LEU1211E, LEU1242E, LEU1244E, LEU1326E, LEU1404F, LEU1417F, LEU1421F, LEU1502F, LYS1207E, LYS1214E, LYS1409F, LYS1422F, MET1209E, MET1327E, PHE1208E, PHE1334E, PHE1336E, PHE1423F, SER1286E, SER1320E, SER1324E, SER1330E, SER1335E, SER1402F, SER1416F, SER1419F, SER1429F, THR1219E, THR1406F, THR1425F, THR1497F, TRP1501F, TYR1221E, VAL1323E, VAL1333E, VAL1407F, VAL1498F
• G-H: ALA2004G, ALA2080G, ALA2081G, ALA2082G, ALA2118G, ALA2119G, ALA2122G, ALA2222H, ALA2225H, ALA2233H, ALA2234H, ALA2332H, ARG2036G, ARG2084G, ARG2085G, ARG2124G, ARG2213H, ASN2008G, ASP2042G, ASP2123G, ASP2130G, ASP2236H, ASP2331H, CYS2078G, GLN2006G, GLN2114G, GLN2121G, GLN2237H, GLU2009G, GLU2117G, GLU2224H, GLU2227H, GLY2010G, GLY2043G, GLY2111G, GLY2113G, GLY2129G, GLY2232H, HIS2014G, HIS2041G, ILE2120G, ILE2220H, ILE2231H, LEU2112G, LEU2115G, LEU2125G, LEU2226H, LEU2230H, LYS2002G, LYS2206H, LYS2214H, LYS2263H, MET2209H, PHE2038G, PHE2128G, PHE2208H, PHE2235H, PHE2265H, PHE2334H, PHE2336H, SER2335H, THR2219H, TRP2223H, TYR2040G, TYR2210H, TYR2221H, VAL2116G, VAL2126G, VAL2127G, VAL2205H, VAL2228H, VAL2229H, VAL2239H, VAL2333H
• G-I: ALA2016G, ALA2020G, ALA2024G, ALA2026G, ALA2027G, ALA2468I, ALA2486I, ALA2500I, ARG2124G, ARG2414I, ARG2469I, ASN2008G, ASN2408I, ASP2018G, ASP2123G, ASP2130G, ASP2435I, ASP2465I, ASP2484I, ASP2490I, ASP2496I, CYS2495I, GLN2006G, GLN2015G, GLN2022G, GLN2499I, GLU2009G, GLU2029G, GLU2413I, GLU2434I, GLU2494I, GLY2031G, GLY2129G, GLY2436I, GLY2487I, HIS2014G, HIS2032G, HIS2041G, ILE2034G, ILE2403I, ILE2437I, LEU2005G, LEU2028G, LEU2125G, LEU2404I, LEU2431I, LEU2462I, LEU2491I, LEU2502I, LYS2002G, LYS2025G, LYS2030G, LYS2409I, MET2001G, PHE2003G, PHE2023G, PHE2128G, PHE2433I, PHE2488I, PRO2464I, SER2017G, SER2019G, SER2402I, SER2416I, THR2406I, THR2492I, THR2493I, THR2497I, TRP2501I, TYR2021G, TYR2485I, VAL2126G, VAL2127G, VAL2489I, VAL2498I
• G-J: ALA2080G, ALA2081G, ALA2082G, ALA2093G, ALA2100G, ALA3080J, ALA3081J, ALA3082J, ALA3093J, ALA3100J, ARG2049G, ARG2058G, ARG2084G, ARG2085G, ARG2095G, ARG3049J, ARG3058J, ARG3084J, ARG3085J, ARG3095J, ASN2008G, ASN2045G, ASN2046G, ASN2062G, ASN2096G, ASN2102G, ASN3008J, ASN3045J, ASN3046J, ASN3062J, ASN3096J, ASN3102J, ASP2042G, ASP2056G, ASP2057G, ASP2089G, ASP2099G, ASP2130G, ASP3042J, ASP3056J, ASP3057J, ASP3089J, ASP3099J, ASP3130J, GLN2013G, GLN2055G, GLN2083G, GLN3013J, GLN3055J, GLN3083J, GLU2009G, GLU2092G, GLU3009J, GLU3092J, GLY2010G, GLY2043G, GLY2086G, GLY2097G, GLY2129G, GLY3010J, GLY3043J, GLY3086J, GLY3097J, GLY3129J, HIS2014G, HIS2041G, HIS2059G, HIS2104G, HIS3014J, HIS3041J, HIS3059J, HIS3104J, ILE2060G, ILE2087G, ILE2103G, ILE3060J, ILE3087J, ILE3103J, LEU2050G, LEU3050J, LYS2098G, LYS3098J, PRO2011G, PRO2053G, PRO2054G, PRO2105G, PRO3011J, PRO3053J, PRO3054J, PRO3105J, THR2048G, THR2051G, THR2052G, THR2101G, THR3048J, THR3051J, THR3052J, THR3101J, TYR2012G, TYR2040G, TYR3012J, TYR3040J, VAL2044G, VAL2061G, VAL2079G, VAL2088G, VAL3044J, VAL3061J, VAL3079J, VAL3088J
• G-K: ALA2016G, ARG2058G, ARG2063G, ASN3264K, ASP2018G, ASP2056G, ASP2057G, ASP2130G, GLN2013G, GLN2015G, GLN2022G, GLN2055G, GLU2009G, GLU3224K, GLU3227K, GLY2129G, GLY3218K, GLY3259K, GLY3261K, HIS2014G, HIS2059G, ILE2060G, ILE3220K, ILE3260K, LYS2025G, LYS3214K, LYS3258K, LYS3263K, MET3262K, PHE3265K, PHE3336K, PRO2011G, PRO2054G, PRO3216K, SER2019G, THR3219K, THR3257K, TRP3223K, TYR2012G, TYR2021G, TYR3217K, TYR3221K
• G-L: ARG3414L, ASP2130G, GLU3413L, HIS2014G, LYS3409L
• G-P: ARG2049G, ARG5095P, ASN2102G, GLN2055G, GLN5114P, GLU5117P, GLY5091P, LEU2050G, LYS2106G, PRO2105G, SER5094P, THR2101G
• H-I: ALA2289H, ALA2321H, ALA2332H, ALA2424I, ALA2428I, ALA2500I, ARG2213H, ARG2284H, ARG2290H, ARG2322H, ARG2414I, ASN2328H, ASN2408I, ASN2415I, ASP2245H, ASP2246H, ASP2283H, ASP2285H, ASP2319H, ASP2331H, ASP2496I, CYS2420I, GLN2499I, GLU2288H, GLU2325H, GLU2329H, GLU2418I, GLU2426I, GLY2247H, GLY2427I, HIS2405I, ILE2318H, ILE2403I, LEU2211H, LEU2242H, LEU2244H, LEU2326H, LEU2404I, LEU2417I, LEU2421I, LEU2502I, LYS2207H, LYS2214H, LYS2409I, LYS2422I, MET2209H, MET2327H, PHE2208H, PHE2334H, PHE2336H, PHE2423I, SER2286H, SER2320H, SER2324H, SER2330H, SER2335H, SER2402I, SER2416I, SER2419I, SER2429I, THR2219H, THR2406I, THR2425I, THR2497I, TRP2501I, TYR2221H, VAL2323H, VAL2333H, VAL2407I, VAL2498I
• H-J: ALA3016J, ARG3058J, ARG3063J, ASN2264H, ASP3018J, ASP3056J, ASP3057J, ASP3130J, GLN3013J, GLN3015J, GLN3022J, GLN3055J, GLU2224H, GLU2227H, GLU3009J, GLY2218H, GLY2259H, GLY2261H, HIS3014J, HIS3059J, ILE2220H, ILE2260H, ILE3060J, LYS2214H, LYS2258H, LYS2263H, LYS3025J, MET2262H, PHE2265H, PHE2336H, PRO2216H, PRO3011J, PRO3054J, SER3019J, THR2219H, THR2257H, TRP2223H, TYR2217H, TYR2221H, TYR3012J, TYR3021J
• H-L: ALA2215H, ALA2289H, ALA3439L, ALA3442L, ALA3468L, ARG2213H, ARG2253H, ARG2290H, ARG3414L, ARG3445L, ARG3469L, ARG3475L, ASN2264H, ASN3408L, ASP2245H, ASP2246H, ASP2256H, ASP2285H, ASP2295H, ASP2296H, ASP3435L, ASP3465L, ASP3484L, GLN2250H, GLN2255H, GLU2288H, GLU3413L, GLU3434L, GLU3447L, GLY2218H, GLY2247H, GLY2254H, GLY2259H, GLY2261H, GLY2291H, GLY3436L, GLY3443L, GLY3463L, GLY3470L, ILE2260H, ILE3437L, LEU2287H, LEU2292H, LEU2297H, LEU3441L, LEU3462L, LEU3466L, LYS2214H, LYS2258H, LYS3409L, LYS3467L, MET2262H, PHE2265H, PHE3412L, PHE3433L, PHE3471L, PRO2216H, PRO3411L, PRO3464L, SER2266H, SER2286H, SER3410L, SER3472L, THR2219H, THR2252H, THR2257H, THR2293H, THR3444L, TYR2217H, TYR2221H, TYR2249H, TYR3438L, TYR3485L, VAL2248H, VAL3446L
• I-J: ARG2414I, ASP3130J, GLU2413I, HIS3014J, LYS2409I
• I-K: ALA2439I, ALA2442I, ALA2468I, ALA3215K, ALA3289K, ARG2414I, ARG2445I, ARG2469I, ARG2475I, ARG3213K, ARG3253K, ARG3290K, ASN2408I, ASN3264K, ASP2435I, ASP2465I, ASP2484I, ASP3245K, ASP3246K, ASP3256K, ASP3285K, ASP3295K, ASP3296K, GLN3250K, GLN3255K, GLU2413I, GLU2434I, GLU2447I, GLU3288K, GLY2436I, GLY2443I, GLY2463I, GLY2470I, GLY3218K, GLY3247K, GLY3254K, GLY3259K, GLY3261K, GLY3291K, ILE2437I, ILE3260K, LEU2441I, LEU2462I, LEU2466I, LEU3287K, LEU3292K, LEU3297K, LYS2409I, LYS2467I, LYS3214K, LYS3258K, MET3262K, PHE2412I, PHE2433I, PHE2471I, PHE3265K, PRO2411I, PRO2464I, PRO3216K, SER2410I, SER2472I, SER3266K, SER3286K, THR2444I, THR3219K, THR3252K, THR3257K, THR3293K, TYR2438I, TYR2485I, TYR3217K, TYR3221K, TYR3249K, VAL2446I, VAL3248K
• I-L: ARG2414I, ARG2445I, ARG3414L, ARG3445L, ASN2415I, ASN3415L, GLU2413I, GLU2418I, GLU3413L, GLU3418L, LEU2502I, LEU3502L, LYS2409I, LYS3409L, PHE2412I, PHE3412L, PRO2411I, PRO3411L, SER2416I, SER2419I, SER3410L, SER3416L, SER3419L
• J-K: ALA3004J, ALA3080J, ALA3081J, ALA3082J, ALA3118J, ALA3119J, ALA3122J, ALA3222K, ALA3225K, ALA3233K, ALA3234K, ALA3332K, ARG3036J, ARG3084J, ARG3085J, ARG3124J, ARG3213K, ASN3008J, ASP3042J, ASP3123J, ASP3130J, ASP3236K, ASP3331K, CYS3078J, GLN3006J, GLN3114J, GLN3121J, GLN3237K, GLU3009J, GLU3117J, GLU3224K, GLU3227K, GLY3010J, GLY3043J, GLY3111J, GLY3113J, GLY3129J, GLY3232K, HIS3014J, HIS3041J, ILE3120J, ILE3220K, ILE3231K, LEU3112J, LEU3115J, LEU3125J, LEU3226K, LEU3230K, LYS3002J, LYS3206K, LYS3214K, LYS3263K, MET3001J, MET3209K, MET3262K, PHE3038J, PHE3128J, PHE3208K, PHE3235K, PHE3265K, PHE3334K, PHE3336K, SER3335K, THR3219K, TRP3223K, TYR3040J, TYR3210K, TYR3221K, VAL3044J, VAL3116J, VAL3126J, VAL3127J, VAL3205K, VAL3228K, VAL3229K, VAL3239K, VAL3333K
• J-L: ALA3004J, ALA3016J, ALA3020J, ALA3024J, ALA3026J, ALA3027J, ALA3468L, ALA3486L, ALA3500L, ARG3063J, ARG3124J, ARG3414L, ARG3469L, ASN3008J, ASN3408L, ASP3018J, ASP3123J, ASP3130J, ASP3435L, ASP3465L, ASP3484L, ASP3490L, ASP3496L, CYS3495L, GLN3006J, GLN3015J, GLN3022J, GLN3499L, GLU3009J, GLU3029J, GLU3413L, GLU3434L, GLU3494L, GLY3031J, GLY3129J, GLY3436L, GLY3487L, HIS3014J, HIS3032J, HIS3041J, ILE3034J, ILE3403L, ILE3437L, LEU3005J, LEU3028J, LEU3125J, LEU3404L, LEU3431L, LEU3462L, LEU3491L, LEU3502L, LYS3002J, LYS3025J, LYS3030J, LYS3409L, MET3001J, PHE3003J, PHE3023J, PHE3128J, PHE3433L, PHE3488L, PRO3464L, SER3017J, SER3019J, SER3402L, SER3416L, THR3406L, THR3492L, THR3493L, THR3497L, TRP3501L, TYR3021J, TYR3485L, VAL3126J, VAL3127J, VAL3489L, VAL3498L
• J-P: ALA3093J, ALA3100J, ARG3095J, ARG5095P, ASN3096J, ASP3099J, GLN5083P, GLN5114P, GLU5092P, GLU5117P, GLY3097J, GLY5111P, GLY5113P, ILE5120P, LEU5112P, LYS3098J, SER3094J, SER5110P, VAL5079P, VAL5116P
• J-Q: ALA3093J, ALA5233Q, ALA5234Q, ARG3095J, ARG3108J, ASN3096J, ASP3089J, ASP5236Q, ASP5274Q, GLN5237Q, GLU3090J, GLU3092J, GLU5227Q, GLU5306Q, GLY3091J, GLY3097J, GLY5232Q, ILE5231Q, LEU5230Q, LYS3098J, PHE5235Q, SER3094J, TYR5275Q, VAL5228Q, VAL5229Q
• K-L: ALA3289K, ALA3321K, ALA3332K, ALA3424L, ALA3428L, ALA3500L, ARG3213K, ARG3284K, ARG3290K, ARG3322K, ARG3414L, ASN3328K, ASN3408L, ASN3415L, ASP3245K, ASP3246K, ASP3283K, ASP3285K, ASP3319K, ASP3331K, ASP3496L, CYS3420L, GLN3499L, GLU3288K, GLU3325K, GLU3329K, GLU3418L, GLU3426L, GLY3247K, GLY3427L, HIS3405L, ILE3318K, ILE3403L, LEU3211K, LEU3242K, LEU3244K, LEU3326K, LEU3404L, LEU3417L, LEU3502L, LYS3207K, LYS3214K, LYS3409L, LYS3422L, MET3209K, MET3327K, PHE3208K, PHE3334K, PHE3336K, PHE3423L, SER3286K, SER3320K, SER3324K, SER3330K, SER3335K, SER3402L, SER3416L, SER3419L, THR3219K, THR3406L, THR3425L, THR3497L, TRP3501L, TYR3221K, VAL3323K, VAL3333K, VAL3407L, VAL3498L
• M-N: ALA4004M, ALA4080M, ALA4081M, ALA4082M, ALA4118M, ALA4119M, ALA4122M, ALA4222N, ALA4225N, ALA4233N, ALA4234N, ALA4332N, ARG4036M, ARG4084M, ARG4085M, ARG4124M, ARG4213N, ASN4008M, ASP4042M, ASP4123M, ASP4130M, ASP4236N, ASP4331N, CYS4078M, GLN4006M, GLN4114M, GLN4121M, GLN4237N, GLU4009M, GLU4117M, GLU4224N, GLU4227N, GLY4010M, GLY4043M, GLY4111M, GLY4113M, GLY4129M, GLY4232N, HIS4014M, HIS4041M, ILE4120M, ILE4220N, ILE4231N, LEU4112M, LEU4115M, LEU4125M, LEU4211N, LEU4226N, LEU4230N, LYS4002M, LYS4206N, LYS4214N, LYS4263N, MET4209N, MET4262N, PHE4038M, PHE4128M, PHE4208N, PHE4235N, PHE4265N, PHE4334N, PHE4336N, SER4335N, THR4219N, TRP4223N, TYR4040M, TYR4210N, TYR4221N, VAL4044M, VAL4116M, VAL4126M, VAL4127M, VAL4205N, VAL4228N, VAL4229N, VAL4239N, VAL4333N
• M-O: ALA4016M, ALA4020M, ALA4024M, ALA4026M, ALA4027M, ALA4468O, ALA4486O, ALA4500O, ARG4124M, ARG4414O, ARG4469O, ASN4008M, ASN4408O, ASP4018M, ASP4123M, ASP4130M, ASP4435O, ASP4465O, ASP4484O, ASP4490O, ASP4496O, CYS4495O, GLN4006M, GLN4015M, GLN4022M, GLN4499O, GLU4009M, GLU4029M, GLU4413O, GLU4434O, GLU4494O, GLY4031M, GLY4129M, GLY4436O, GLY4487O, HIS4014M, HIS4032M, HIS4041M, ILE4034M, ILE4403O, ILE4437O, LEU4005M, LEU4028M, LEU4125M, LEU4404O, LEU4431O, LEU4462O, LEU4491O, LEU4502O, LYS4002M, LYS4025M, LYS4030M, LYS4409O, MET4001M, PHE4003M, PHE4023M, PHE4128M, PHE4433O, PHE4488O, PRO4464O, SER4017M, SER4019M, SER4402O, SER4416O, THR4406O, THR4492O, THR4493O, THR4497O, TRP4501O, TYR4021M, TYR4485O, VAL4126M, VAL4127M, VAL4489O, VAL4498O
• M-P: ALA4080M, ALA4081M, ALA4082M, ALA4093M, ALA4100M, ALA5080P, ALA5081P, ALA5082P, ALA5093P, ALA5100P, ARG4049M, ARG4058M, ARG4084M, ARG4085M, ARG4095M, ARG5049P, ARG5058P, ARG5084P, ARG5085P, ARG5095P, ASN4008M, ASN4045M, ASN4046M, ASN4062M, ASN4096M, ASN4102M, ASN5008P, ASN5045P, ASN5046P, ASN5062P, ASN5096P, ASN5102P, ASP4042M, ASP4056M, ASP4057M, ASP4089M, ASP4099M, ASP4130M, ASP5042P, ASP5056P, ASP5057P, ASP5089P, ASP5099P, ASP5130P, GLN4013M, GLN4055M, GLN4083M, GLN5013P, GLN5055P, GLN5083P, GLU4009M, GLU4092M, GLU5009P, GLU5092P, GLY4010M, GLY4043M, GLY4086M, GLY4097M, GLY4129M, GLY5010P, GLY5043P, GLY5086P, GLY5097P, GLY5129P, HIS4014M, HIS4041M, HIS4059M, HIS4104M, HIS5014P, HIS5041P, HIS5059P, HIS5104P, ILE4060M, ILE4087M, ILE4103M, ILE5060P, ILE5087P, ILE5103P, LEU4050M, LEU5050P, LYS4098M, LYS5098P, PRO4011M, PRO4053M, PRO4054M, PRO4105M, PRO5011P, PRO5053P, PRO5054P, PRO5105P, THR4048M, THR4051M, THR4052M, THR4101M, THR5048P, THR5051P, THR5052P, THR5101P, TYR4012M, TYR4040M, TYR5012P, TYR5040P, VAL4044M, VAL4061M, VAL4079M, VAL4088M, VAL5044P, VAL5061P, VAL5079P, VAL5088P
• M-Q: ALA4016M, ARG4058M, ARG4063M, ASN5264Q, ASP4018M, ASP4056M, ASP4057M, ASP4130M, GLN4013M, GLN4015M, GLN4022M, GLN4055M, GLU4009M, GLU5224Q, GLU5227Q, GLY4129M, GLY5218Q, GLY5259Q, GLY5261Q, HIS4014M, HIS4059M, ILE4060M, ILE5220Q, ILE5260Q, LYS4025M, LYS5214Q, LYS5258Q, LYS5263Q, MET5262Q, PHE5265Q, PHE5336Q, PRO4011M, PRO4054M, PRO5216Q, SER4019M, THR5219Q, THR5257Q, TRP5223Q, TYR4012M, TYR4021M, TYR5217Q, TYR5221Q
• M-R: ARG5414R, ASP4130M, GLU5413R, HIS4014M, LYS5409R
• N-O: ALA4289N, ALA4321N, ALA4332N, ALA4424O, ALA4428O, ALA4500O, ARG4213N, ARG4284N, ARG4290N, ARG4322N, ARG4414O, ASN4212N, ASN4328N, ASN4408O, ASN4415O, ASP4245N, ASP4246N, ASP4283N, ASP4285N, ASP4319N, ASP4331N, ASP4496O, CYS4420O, GLN4499O, GLU4288N, GLU4325N, GLU4329N, GLU4418O, GLU4426O, GLY4247N, GLY4427O, HIS4405O, ILE4318N, ILE4403O, LEU4211N, LEU4242N, LEU4244N, LEU4326N, LEU4404O, LEU4417O, LEU4502O, LYS4207N, LYS4214N, LYS4409O, LYS4422O, MET4209N, MET4327N, PHE4208N, PHE4334N, PHE4336N, PHE4423O, SER4286N, SER4320N, SER4324N, SER4330N, SER4335N, SER4402O, SER4416O, SER4419O, SER4429O, THR4219N, THR4406O, THR4425O, THR4497O, TRP4501O, TYR4221N, VAL4323N, VAL4333N, VAL4407O, VAL4498O
• N-P: ALA5016P, ARG5058P, ARG5063P, ASN4264N, ASP5018P, ASP5056P, ASP5057P, ASP5130P, GLN5013P, GLN5015P, GLN5022P, GLN5055P, GLU4224N, GLU4227N, GLU5009P, GLY4218N, GLY4259N, GLY4261N, GLY5129P, HIS5014P, HIS5059P, ILE4220N, ILE4260N, ILE5060P, LYS4214N, LYS4258N, LYS4263N, MET4262N, PHE4265N, PHE4336N, PRO4216N, PRO5011P, PRO5054P, SER5019P, THR4219N, THR4257N, TRP4223N, TYR4217N, TYR4221N, TYR5012P, TYR5021P
• N-R: ALA4215N, ALA4289N, ALA5439R, ALA5442R, ALA5468R, ARG4213N, ARG4253N, ARG4290N, ARG5414R, ARG5445R, ARG5469R, ARG5475R, ASN4264N, ASN5408R, ASP4245N, ASP4246N, ASP4256N, ASP4285N, ASP4295N, ASP4296N, ASP5435R, ASP5465R, ASP5484R, GLN4250N, GLN4255N, GLU4288N, GLU5413R, GLU5434R, GLU5447R, GLY4218N, GLY4247N, GLY4254N, GLY4259N, GLY4261N, GLY4291N, GLY5436R, GLY5443R, GLY5463R, GLY5470R, ILE4260N, ILE5437R, LEU4251N, LEU4287N, LEU4292N, LEU4297N, LEU5441R, LEU5462R, LEU5466R, LYS4214N, LYS4258N, LYS5409R, LYS5467R, MET4262N, PHE5412R, PHE5433R, PHE5471R, PRO4216N, PRO5411R, PRO5464R, SER4266N, SER4286N, SER5410R, SER5472R, THR4219N, THR4252N, THR4257N, THR4293N, THR5444R, TYR4217N, TYR4221N, TYR4249N, TYR5438R, TYR5485R, VAL4248N, VAL5446R
• O-P: ARG4414O, ASP5130P, GLU4413O, HIS5014P, LYS4409O
• O-Q: ALA4439O, ALA4442O, ALA4468O, ALA5215Q, ALA5289Q, ARG4414O, ARG4445O, ARG4469O, ARG4475O, ARG5213Q, ARG5253Q, ARG5290Q, ASN4408O, ASN5264Q, ASP4435O, ASP4465O, ASP4484O, ASP5245Q, ASP5246Q, ASP5256Q, ASP5285Q, ASP5295Q, ASP5296Q, GLN5250Q, GLN5255Q, GLU4413O, GLU4434O, GLU4447O, GLU5288Q, GLY4436O, GLY4443O, GLY4463O, GLY4470O, GLY5218Q, GLY5247Q, GLY5254Q, GLY5259Q, GLY5261Q, GLY5291Q, ILE4437O, ILE5260Q, LEU4441O, LEU4462O, LEU4466O, LEU5287Q, LEU5292Q, LEU5297Q, LYS4409O, LYS4467O, LYS5214Q, LYS5258Q, LYS5263Q, MET5262Q, PHE4412O, PHE4433O, PHE4471O, PHE5265Q, PRO4411O, PRO4464O, PRO5216Q, SER4410O, SER4472O, SER5266Q, SER5286Q, THR4444O, THR5219Q, THR5252Q, THR5257Q, THR5293Q, TYR4438O, TYR4485O, TYR5217Q, TYR5221Q, TYR5249Q, VAL4446O, VAL5248Q
• O-R: ARG4414O, ARG4445O, ARG5414R, ARG5445R, ASN4415O, ASN5415R, GLU4413O, GLU4418O, GLU5413R, GLU5418R, LEU4502O, LEU5502R, LYS4409O, LYS5409R, PHE4412O, PHE5412R, PRO4411O, PRO5411R, SER4410O, SER4416O, SER4419O, SER5410R, SER5416R, SER5419R
• P-Q: ALA5004P, ALA5080P, ALA5081P, ALA5082P, ALA5118P, ALA5119P, ALA5122P, ALA5222Q, ALA5225Q, ALA5233Q, ALA5234Q, ALA5332Q, ARG5036P, ARG5084P, ARG5085P, ARG5124P, ARG5213Q, ASN5008P, ASP5042P, ASP5123P, ASP5130P, ASP5236Q, ASP5331Q, CYS5078P, GLN5006P, GLN5114P, GLN5121P, GLN5237Q, GLU5009P, GLU5117P, GLU5224Q, GLU5227Q, GLY5010P, GLY5043P, GLY5111P, GLY5113P, GLY5129P, GLY5232Q, HIS5014P, HIS5041P, ILE5120P, ILE5220Q, ILE5231Q, LEU5112P, LEU5115P, LEU5125P, LEU5211Q, LEU5226Q, LEU5230Q, LYS5002P, LYS5206Q, LYS5214Q, LYS5263Q, MET5209Q, MET5262Q, PHE5038P, PHE5128P, PHE5208Q, PHE5235Q, PHE5265Q, PHE5334Q, PHE5336Q, SER5335Q, THR5219Q, TRP5223Q, TYR5040P, TYR5210Q, TYR5221Q, VAL5044P, VAL5116P, VAL5126P, VAL5127P, VAL5205Q, VAL5228Q, VAL5229Q, VAL5239Q, VAL5333Q
• P-R: ALA5016P, ALA5020P, ALA5024P, ALA5026P, ALA5027P, ALA5468R, ALA5486R, ALA5500R, ARG5124P, ARG5414R, ARG5469R, ASN5008P, ASN5408R, ASP5018P, ASP5123P, ASP5130P, ASP5435R, ASP5465R, ASP5484R, ASP5490R, ASP5496R, CYS5495R, GLN5006P, GLN5013P, GLN5015P, GLN5022P, GLN5499R, GLU5009P, GLU5029P, GLU5413R, GLU5434R, GLU5494R, GLY5031P, GLY5129P, GLY5436R, GLY5487R, HIS5014P, HIS5032P, HIS5041P, ILE5034P, ILE5437R, LEU5005P, LEU5028P, LEU5125P, LEU5404R, LEU5431R, LEU5462R, LEU5491R, LEU5502R, LYS5002P, LYS5025P, LYS5030P, LYS5409R, MET5001P, PHE5003P, PHE5023P, PHE5128P, PHE5433R, PHE5488R, PRO5464R, SER5017P, SER5019P, SER5402R, SER5416R, THR5406R, THR5492R, THR5493R, THR5497R, TRP5501R, TYR5021P, TYR5485R, VAL5126P, VAL5127P, VAL5489R, VAL5498R
• Q-R: ALA5289Q, ALA5321Q, ALA5332Q, ALA5424R, ALA5428R, ALA5500R, ARG5213Q, ARG5284Q, ARG5290Q, ARG5322Q, ARG5414R, ASN5212Q, ASN5328Q, ASN5408R, ASN5415R, ASP5245Q, ASP5246Q, ASP5283Q, ASP5285Q, ASP5319Q, ASP5331Q, ASP5496R, CYS5420R, GLN5499R, GLU5288Q, GLU5325Q, GLU5329Q, GLU5418R, GLU5426R, GLY5247Q, GLY5427R, HIS5405R, ILE5318Q, ILE5403R, LEU5211Q, LEU5242Q, LEU5244Q, LEU5326Q, LEU5404R, LEU5417R, LEU5502R, LYS5207Q, LYS5214Q, LYS5409R, LYS5422R, MET5209Q, MET5327Q, PHE5208Q, PHE5334Q, PHE5336Q, PHE5423R, SER5286Q, SER5320Q, SER5324Q, SER5330Q, SER5335Q, SER5402R, SER5416R, SER5419R, SER5429R, THR5219Q, THR5406R, THR5425R, THR5497R, TRP5501R, TYR5221Q, VAL5323Q, VAL5333Q, VAL5407R, VAL5498R