2HRE

structure of human ferrochelatase variant e343k with protoporphyrin ix bound

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 173
  • Norm. En. per Res.: -3.6852
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-96.0919	-38.1522	-503.302	-637.546	173	41	3	21184	2	38	41
A-C	0.0	7.7194	-41.6083	-33.8889	32	1	0	1821	0	7	9
C-D	-70.0269	-27.3054	-496.336	-593.6683	169	33	3	20928	0	39	40

Interface residues

• A-B: ALA282A, ALA282B, ARG226A, ARG226B, ARG253B, ARG272A, ARG272B, ARG290A, ARG298A, ARG298B, ARG325A, ARG325B, ARG327A, ARG327B, ARG412A, ARG412B, ASN271A, ASN271B, ASN295A, ASN295B, ASN408A, ASN408B, ASP274A, ASP274B, ASP316A, ASP316B, CYS196A, CYS196B, CYS294A, CYS294B, CYS323A, CYS323B, CYS403A, CYS403B, CYS406A, CYS406B, CYS411A, CYS411B, GLN278A, GLN278B, GLN285A, GLN285B, GLN314A, GLN314B, GLN398A, GLN398B, GLU255A, GLU255B, GLU279A, GLU279B, GLU289A, GLU289B, GLU292A, GLU292B, GLU317A, GLU317B, GLU324A, GLU324B, GLY273A, GLY273B, GLY312A, GLY312B, GLY321A, GLY321B, GLY326A, GLY326B, HIS230A, HIS230B, ILE234A, ILE258A, ILE258B, ILE319A, ILE319B, ILE330A, ILE330B, LEU259A, LEU259B, LEU299A, LEU299B, LEU311A, LEU311B, LEU322A, LEU322B, LEU399A, LEU399B, LEU401A, LEU401B, LEU405A, LEU405B, LYS286A, LYS286B, LYS304A, LYS304B, LYS320A, LYS320B, LYS397A, LYS397B, LYS415A, LYS415B, MET267A, MET267B, MET288A, MET288B, PHE260A, PHE260B, PRO228A, PRO228B, PRO275A, PRO275B, PRO277A, PRO277B, PRO296A, PRO296B, PRO309A, PRO309B, PRO313A, PRO313B, PRO404A, PRO404B, SER195A, SER195B, SER254A, SER254B, SER268A, SER268B, SER281A, SER281B, SER318A, SER318B, SER396A, SER396B, SER402A, SER402B, THR229A, THR229B, THR283A, THR283B, THR315A, THR315B, THR400A, THR400B, THR419A, TRP227A, TRP301A, TRP301B, TRP310A, TRP310B, TYR194A, TYR194B, TYR276A, TYR276B, TYR293A, TYR293B, TYR297A, TYR297B, VAL256A, VAL256B, VAL257A, VAL257B, VAL269A, VAL269B, VAL270A, VAL270B, VAL280A, VAL280B, VAL284A, VAL284B, VAL287A, VAL287B, VAL300A, VAL300B, VAL407A, VAL407B
• A-C: ARG124A, ARG125A, ARG208C, ARG215C, ASN105C, ASN211C, ASP84A, GLN120A, GLN212C, GLU121A, GLU176A, GLU413C, GLU80A, GLY127A, GLY128A, GLY129A, GLY214C, GLY83A, ILE103C, ILE126A, LEU82A, LYS106C, LYS133A, LYS158A, LYS216C, PRO67A, THR81A, TYR123A, TYR159A, TYR207C, TYR210C, VAL213C
• C-D: ALA282C, ALA282D, ARG226C, ARG226D, ARG253D, ARG272C, ARG272D, ARG298C, ARG298D, ARG325C, ARG325D, ARG327C, ARG327D, ARG412C, ARG412D, ASN271C, ASN271D, ASN295C, ASN295D, ASN408C, ASN408D, ASP274C, ASP274D, ASP316C, ASP316D, CYS196C, CYS196D, CYS294C, CYS294D, CYS323C, CYS323D, CYS403C, CYS403D, CYS406C, CYS406D, CYS411D, GLN278C, GLN278D, GLN285C, GLN285D, GLN314C, GLN314D, GLN398C, GLN398D, GLU255C, GLU255D, GLU279C, GLU279D, GLU289C, GLU289D, GLU292C, GLU292D, GLU317C, GLU317D, GLU324C, GLU324D, GLY273C, GLY273D, GLY312C, GLY312D, GLY321C, GLY321D, GLY326C, GLY326D, HIS230C, HIS230D, ILE234C, ILE258C, ILE258D, ILE319C, ILE319D, ILE330C, ILE330D, LEU259C, LEU259D, LEU299C, LEU299D, LEU311C, LEU311D, LEU322C, LEU322D, LEU399C, LEU399D, LEU401C, LEU401D, LEU405C, LEU405D, LYS286C, LYS286D, LYS320C, LYS320D, LYS397C, LYS397D, LYS415C, LYS415D, MET267C, MET267D, MET288C, MET288D, PHE260C, PHE260D, PRO228C, PRO228D, PRO275C, PRO275D, PRO277C, PRO277D, PRO296C, PRO296D, PRO309C, PRO309D, PRO313C, PRO313D, PRO404C, PRO404D, SER195C, SER195D, SER254C, SER254D, SER268C, SER268D, SER281C, SER281D, SER318C, SER318D, SER396C, SER396D, SER402C, SER402D, THR229C, THR229D, THR283C, THR283D, THR315C, THR315D, THR400C, THR400D, THR419C, TRP227C, TRP301C, TRP301D, TRP310C, TRP310D, TYR194C, TYR194D, TYR276C, TYR276D, TYR293C, TYR293D, TYR297C, TYR297D, VAL256C, VAL256D, VAL257C, VAL257D, VAL269C, VAL269D, VAL270C, VAL270D, VAL280C, VAL280D, VAL284C, VAL284D, VAL287C, VAL287D, VAL300C, VAL300D, VAL407C, VAL407D