2HLD

crystal structure of yeast mitochondrial f1-atpase

• Total interactions analyzed: 351
• Total true interactions: 58
• Strongest Interaction:
  • Chains: G-I
  • Int. Res.: 94
  • Norm. En. per Res.: -3.3677
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.019	-0.019	2	0	0	11	0	0	0
A-D	-72.7154	-99.1672	-530.553	-702.4356	241	23	11	22679	6	59	73
A-E	-100.3741	-9.6371	-461.017	-571.0282	208	24	10	20090	5	67	67
A-G	0.0	-2.4089	-98.0836	-100.4925	73	2	1	4760	0	24	15
A-I	0.0	0.0	-0.0018	-0.0018	3	0	0	2	0	0	0
B-E	-67.2776	-48.4284	-458.807	-574.5131	196	26	12	18910	3	44	54
B-F	-90.6244	-45.7965	-571.704	-708.1249	246	32	13	23898	9	78	70
B-G	-4.3788	-31.0553	-31.3715	-66.8056	51	3	0	1970	1	13	4
B-N	-20.3983	4.1138	-16.3063	-32.5908	24	5	0	836	0	15	11
C-D	-79.005	18.9184	-468.404	-528.4906	243	17	11	20923	3	70	71
C-F	-85.4894	-77.3339	-510.299	-673.1223	239	18	11	21964	7	58	73
C-G	-22.793	41.6281	-44.9653	-26.1302	50	2	0	2272	1	13	12
C-I	0.0	0.0	-0.0596	-0.0596	5	0	0	18	0	1	2
D-F	0.0	0.0	-0.4202	-0.4202	7	0	0	103	0	0	1
D-G	-6.9067	-28.4619	-79.2135	-114.5822	68	2	5	4245	3	24	18
D-I	0.0	0.0	-0.0098	-0.0098	2	0	0	1	0	1	3
E-G	-10.0958	-39.6567	-79.1897	-128.9422	53	3	2	3750	2	12	4
E-K	0.0	2.5994	-10.614	-8.0146	18	1	0	666	0	12	18
E-N	-3.025	-16.0297	-9.362	-28.4167	41	0	0	924	2	21	18
E-T	0.0	-4.5429			2
F-G	-17.3474	-54.0713	-92.052	-163.4707	76	6	4	4525	3	28	15
G-H	-11.9867	-2.3764	-240.607	-254.9701	92	6	9	9693	0	22	19
G-I	-67.5459	5.8687	-254.885	-316.5622	94	21	16	10797	1	14	14
H-I	-6.2094	-9.0637	-88.0924	-103.3654	66	7	12	4682	2	7	6
J-K	0.0	0.0	-0.0041	-0.0041	3	0	0	8	0	0	0
J-M	-120.4469	-100.3897	-540.437	-761.2736	242	32	11	22489	8	57	74
J-N	-87.579	-7.5965	-497.666	-592.8414	225	24	9	21445	5	74	70
J-P	-3.0186	-17.4879	-81.5412	-102.0477	73	0	2	4182	4	22	15
K-N	-57.3018	-48.2715	-432.89	-538.4633	191	16	11	18006	3	44	51
K-O	-82.3458	-39.2376	-590.452	-712.0354	247	32	13	24461	10	80	72
K-P	0.0	-24.4797	-36.4302	-60.9099	59	0	0	2338	2	14	8
K-T	0.0	-5.0716			2
K-X	0.0	5.6322			4
L-M	-67.3163	-23.0911	-661.031	-751.4384	285	26	15	28603	7	92	77
L-O	-94.1098	-98.7045	-505.623	-698.4374	231	29	12	21748	8	56	71
L-P	-7.8696	22.0354	-30.1683	-16.0025	42	1	0	1682	0	10	6
M-O	0.0	0.0	-11.054	-11.054	10	1	2	771	0	0	4
M-P	-12.7863	-13.4092	-92.0406	-118.2361	75	8	5	4793	2	32	23
M-R	0.0	0.0	-0.0345	-0.0345	2	0	0	5	0	1	2
N-P	-21.1172	-60.8156	-113.399	-195.3318	65	12	2	5105	3	19	7
O-P	-3.0383	-27.9811	-78.0039	-109.0233	76	5	4	3880	2	25	15
O-X	0.0	0.7399			2
P-Q	-17.9279	0.0	-129.414	-147.3419	78	4	7	5344	0	16	16
P-R	-10.9542	0.0	-82.3829	-93.3371	65	2	13	4405	0	4	7
Q-R	0.0	0.0	-26.0123	-26.0123	46	0	10	1665	0	5	3
S-V	-69.8988	-90.9553			33
S-W	-69.3335	-3.7627			32
S-Y	0.0	-0.6598			10
T-W	-51.2518	-42.9572			24
T-X	-88.3931	-42.7381			39
T-Y	0.0	-34.666			5
U-V	-74.1763	-0.8568			33
U-X	-77.94	-81.7927			39
U-Y	-20.9886	11.4177			10
V-Y	0.0	-31.1715			8
W-Y	-8.7951	-31.1933			8
X-Y	0.0	-45.428			4
Y-1	-9.8554	0.0			2

Interface residues

• A-B: ARG288B, PRO290A
• A-D: ALA119D, ALA125D, ALA131D, ALA216A, ALA235A, ALA238A, ALA241A, ALA242A, ALA270D, ALA278D, ALA279A, ALA286D, ALA295A, ALA323D, ALA327D, ALA32D, ALA331D, ALA356A, ALA35A, ALA360D, ALA361D, ALA36D, ALA371D, ALA404A, ALA406A, ALA41A, ALA51D, ARG173A, ARG212A, ARG274D, ARG281A, ARG288A, ARG289A, ARG293A, ARG295D, ARG356D, ARG364A, ARG42A, ARG60D, ARG82A, ASN35D, ASN433A, ASN57D, ASP111A, ASP118A, ASP120D, ASP172A, ASP272A, ASP288D, ASP316D, ASP319D, ASP330D, ASP335A, ASP349D, ASP352D, ASP359D, ASP369D, ASP38A, ASP400D, ASP78D, ASP81A, GLN127D, GLN174A, GLN210A, GLN217A, GLN220A, GLN224A, GLN245A, GLN27D, GLN282A, GLN282D, GLN293D, GLN332A, GLN365D, GLN375D, GLN379D, GLN399D, GLN407A, GLN428A, GLN434A, GLN52D, GLU126D, GLU240A, GLU294A, GLU294D, GLU29D, GLU330A, GLU357A, GLU376D, GLU395D, GLU398D, GLU49D, GLU56D, GLU86A, GLU88A, GLY119A, GLY151D, GLY176A, GLY209A, GLY273D, GLY280D, GLY290D, GLY292A, GLY333A, GLY334A, GLY362A, GLY37A, GLY39A, GLY55D, GLY79A, GLY80D, GLY81D, GLY87A, HIS118D, HIS328D, HIS53D, ILE117A, ILE153D, ILE233A, ILE275D, ILE296D, ILE33D, ILE363A, ILE387D, ILE40A, ILE62D, ILE83D, ILE9D, LEU218A, LEU244A, LEU272D, LEU283A, LEU285A, LEU285D, LEU286A, LEU287A, LEU291D, LEU292D, LEU30D, LEU317D, LEU329D, LEU34A, LEU34D, LEU351D, LEU357D, LEU358A, LEU358D, LEU378D, LEU384D, LEU391D, LEU396D, LEU460A, LEU54D, LEU77A, LEU83A, LYS120A, LYS152D, LYS211A, LYS275A, LYS300D, LYS354D, LYS361A, LYS373D, LYS382D, LYS431A, LYS85A, MET228A, MET289D, PHE124D, PHE156D, PHE326D, PHE359A, PRO116A, PRO116D, PRO121D, PRO122D, PRO243A, PRO276D, PRO283D, PRO290A, PRO291A, PRO31D, PRO320D, PRO322D, PRO350D, PRO82D, SER123D, SER128D, SER130D, SER213A, SER239A, SER269D, SER277D, SER284A, SER28D, SER353D, SER355D, SER372D, SER383D, SER397D, SER410A, SER461A, SER80A, THR129D, THR175A, THR214A, THR221A, THR237A, THR284D, THR287D, THR297D, THR298D, THR299D, THR318D, THR324D, THR325D, THR331A, THR332D, THR377D, THR380D, THR58D, TYR281D, TYR296A, TYR360A, TYR368D, TYR435A, VAL109A, VAL110A, VAL215A, VAL219A, VAL278A, VAL279D, VAL312D, VAL334D, VAL33A, VAL362D, VAL36A, VAL374D, VAL50D, VAL59D, VAL84A
• A-E: ALA135A, ALA159E, ALA15E, ALA19E, ALA228E, ALA264E, ALA270E, ALA311A, ALA312A, ALA314E, ALA379A, ALA380A, ALA397A, ALA51A, ALA63E, ALA65A, ARG106E, ARG130A, ARG141A, ARG142A, ARG163A, ARG166A, ARG190E, ARG192E, ARG199E, ARG229E, ARG260E, ARG274E, ARG288A, ARG289A, ARG293A, ARG306A, ARG310A, ARG337E, ARG375A, ARG60E, ARG72E, ARG92A, ASN195E, ASN223E, ASN28A, ASN343A, ASN47A, ASN48A, ASN67A, ASN97E, ASP104E, ASP196E, ASP22E, ASP256E, ASP299A, ASP315E, ASP319E, ASP335A, ASP349A, ASP413A, ASP65E, GLN132A, GLN165A, GLN221E, GLN263E, GLN351A, GLN43E, GLN50A, GLN72A, GLU105E, GLU189E, GLU193E, GLU200E, GLU203E, GLU224E, GLU267E, GLU294A, GLU309A, GLU318A, GLU341E, GLU401A, GLU52A, GLU53A, GLU68E, GLU69A, GLU74E, GLY137A, GLY157E, GLY158E, GLY160E, GLY162A, GLY164A, GLY186E, GLY188E, GLY18E, GLY194E, GLY220E, GLY227E, GLY273E, GLY280E, GLY292A, GLY298A, GLY31A, GLY350A, GLY377A, GLY45A, GLY66E, GLY69E, GLY71A, GLY73E, GLY74A, HIS24E, HIS304A, ILE103E, ILE138A, ILE17E, ILE20E, ILE275E, ILE345A, ILE347A, ILE390E, ILE49A, ILE75A, ILE95E, ILE96A, ILE96E, LEU139A, LEU197E, LEU209E, LEU217E, LEU271E, LEU272E, LEU27A, LEU287A, LEU303A, LEU307A, LEU308A, LEU314A, LEU394A, LEU46A, LEU46E, LEU54E, LEU66A, LEU68A, LEU70E, LYS134A, LYS163E, LYS202E, LYS313A, LYS317A, LYS393A, LYS45E, MET222E, MET64A, MET64E, PHE219E, PHE259E, PHE301A, PHE44A, PRO136A, PRO140A, PRO225E, PRO226E, PRO276E, PRO290A, PRO291A, PRO297A, PRO313E, PRO42E, PRO70A, SER143A, SER266E, SER269E, SER284A, SER305A, SER315A, SER337A, SER346A, SER374A, THR14E, THR191E, THR30A, THR342A, THR348A, THR41E, THR58E, THR67E, TYR198E, TYR246A, TYR280A, TYR281E, TYR296A, TYR302A, TYR311E, TYR339A, VAL133A, VAL13E, VAL144A, VAL16E, VAL218E, VAL21E, VAL268E, VAL279E, VAL300A, VAL336A, VAL344A, VAL373A, VAL376A, VAL43A, VAL71E, VAL73A, VAL97A
• A-G: ALA137G, ALA274G, ALA27G, ALA295A, ALA338A, ALA34G, ALA403A, ALA404A, ALA406A, ALA414A, ARG259G, ARG281A, ARG288A, ARG289A, ARG293A, ARG30G, ARG400A, ASP136G, ASP269G, ASP335A, ASP411A, ASP413A, GLN260G, GLN407A, GLU266G, GLU294A, GLU357A, GLU401A, GLU7G, GLY273G, GLY292A, GLY333A, GLY334A, ILE19G, ILE230G, ILE25G, ILE263G, ILE270G, ILE271G, LEU267G, LEU285A, LEU31G, LEU3G, LEU412A, LYS11G, LYS135G, LYS18G, LYS21G, LYS24G, LYS33G, LYS4G, MET23G, PHE405A, PRO290A, PRO291A, SER275G, SER276G, SER28G, SER337A, SER410A, THR22G, THR264G, THR272G, THR29G, THR342A, THR416A, TYR226G, TYR255G, TYR296A, TYR339A, VAL262G, VAL26G, VAL402A
• A-I: ASN36I, ASP411A, SER410A
• B-E: ALA119E, ALA125E, ALA131E, ALA148E, ALA207B, ALA216B, ALA235B, ALA238B, ALA241B, ALA242B, ALA278E, ALA279B, ALA286E, ALA295B, ALA323E, ALA327E, ALA32E, ALA331E, ALA35B, ALA361E, ALA36E, ALA41B, ALA51E, ARG108B, ARG149E, ARG173B, ARG212B, ARG274E, ARG281B, ARG288B, ARG289B, ARG293B, ARG295E, ARG32B, ARG356E, ARG364B, ARG42B, ARG60E, ARG82B, ASN35E, ASN57E, ASP111B, ASP118B, ASP120E, ASP172B, ASP288E, ASP316E, ASP319E, ASP330E, ASP335B, ASP352E, ASP359E, ASP38B, ASP78E, ASP81B, GLN127E, GLN174B, GLN210B, GLN217B, GLN220B, GLN224B, GLN245B, GLN27E, GLN282B, GLN282E, GLN293E, GLN332B, GLN379E, GLN434B, GLN52E, GLU126E, GLU132E, GLU223B, GLU240B, GLU294B, GLU294E, GLU29E, GLU330B, GLU49E, GLU56E, GLU86B, GLU88B, GLY119B, GLY150E, GLY151E, GLY209B, GLY273E, GLY280E, GLY290E, GLY292B, GLY333B, GLY334B, GLY37B, GLY39B, GLY55E, GLY80E, GLY81E, GLY87B, HIS118E, HIS328E, HIS53E, ILE117B, ILE233B, ILE275E, ILE296E, ILE33E, ILE40B, ILE83E, ILE9E, LEU218B, LEU272E, LEU283B, LEU285B, LEU285E, LEU286B, LEU287B, LEU291E, LEU292E, LEU30E, LEU317E, LEU329E, LEU34B, LEU34E, LEU351E, LEU357E, LEU358E, LEU54E, LEU77B, LEU83B, LYS120B, LYS152E, LYS211B, LYS275B, LYS354E, LYS382E, LYS85B, MET228B, MET289E, PHE124E, PHE156E, PHE326E, PHE359B, PRO116B, PRO116E, PRO121E, PRO122E, PRO243B, PRO276E, PRO283E, PRO290B, PRO291B, PRO31E, PRO320E, PRO322E, PRO82E, SER123E, SER128E, SER130E, SER213B, SER239B, SER269E, SER277E, SER284B, SER28E, SER80B, THR129E, THR214B, THR221B, THR237B, THR284E, THR287E, THR297E, THR298E, THR318E, THR324E, THR325E, THR331B, THR332E, THR58E, TYR281E, TYR296B, TYR360B, TYR368E, TYR435B, VAL109B, VAL110B, VAL215B, VAL219B, VAL278B, VAL279E, VAL33B, VAL362E, VAL36B, VAL50E, VAL59E, VAL84B
• B-F: ALA131B, ALA135B, ALA159F, ALA15F, ALA19F, ALA228F, ALA264F, ALA270F, ALA278F, ALA295B, ALA311B, ALA312B, ALA314F, ALA321F, ALA338B, ALA379B, ALA397B, ALA51B, ALA65B, ARG106F, ARG130B, ARG141B, ARG142B, ARG166B, ARG190F, ARG192F, ARG199F, ARG229F, ARG260F, ARG274F, ARG288B, ARG289B, ARG293B, ARG306B, ARG310B, ARG337F, ARG375B, ARG400B, ARG408F, ARG412F, ARG60F, ARG72F, ARG92B, ASN195F, ASN223F, ASN257F, ASN28B, ASN343B, ASN368B, ASN47B, ASN48B, ASN67B, ASN97F, ASP104F, ASP196F, ASP22F, ASP299B, ASP315F, ASP316F, ASP319F, ASP335B, ASP349B, ASP394F, ASP65F, GLN132B, GLN165B, GLN221F, GLN263F, GLN282F, GLN351B, GLN398B, GLN43F, GLN50B, GLN72B, GLU105F, GLU189F, GLU193F, GLU224F, GLU267F, GLU294B, GLU309B, GLU318B, GLU341F, GLU401B, GLU422F, GLU52B, GLU53B, GLU68F, GLU69B, GLU74F, GLY137B, GLY157F, GLY158F, GLY160F, GLY162F, GLY164B, GLY186F, GLY188F, GLY18F, GLY194F, GLY220F, GLY227F, GLY280F, GLY292B, GLY298B, GLY343F, GLY350B, GLY370B, GLY377B, GLY392F, GLY426F, GLY45B, GLY66F, GLY69F, GLY71B, GLY73F, GLY74B, HIS24F, HIS304B, HIS455F, ILE103F, ILE138B, ILE17F, ILE20F, ILE275F, ILE340B, ILE345B, ILE347B, ILE388F, ILE427F, ILE49B, ILE75B, ILE95F, ILE96B, ILE96F, LEU139B, LEU197F, LEU209F, LEU217F, LEU271F, LEU27B, LEU287B, LEU303B, LEU307B, LEU308B, LEU314B, LEU317F, LEU342F, LEU371B, LEU394B, LEU46B, LEU54F, LEU66B, LEU68B, LEU70F, LYS134B, LYS163F, LYS202F, LYS313B, LYS317B, LYS386B, LYS393B, LYS469F, MET222F, MET393F, MET459F, MET64F, PHE219F, PHE259F, PHE301B, PHE405B, PHE424F, PHE44B, PRO136B, PRO140B, PRO160B, PRO225F, PRO226F, PRO276F, PRO283F, PRO290B, PRO291B, PRO297B, PRO313F, PRO320F, PRO322F, PRO341B, PRO42F, PRO70B, SER143B, SER266F, SER269F, SER277F, SER305B, SER315B, SER337B, SER340F, SER346B, SER374B, SER378B, SER391B, SER410B, THR14F, THR164F, THR191F, THR30B, THR318F, THR342B, THR348B, THR425F, THR58F, THR67F, TYR198F, TYR280B, TYR281F, TYR296B, TYR302B, TYR311F, TYR339B, TYR345F, TYR381F, TYR458F, VAL133B, VAL13F, VAL144B, VAL159B, VAL161F, VAL165F, VAL16F, VAL187F, VAL218F, VAL21F, VAL268F, VAL279F, VAL300B, VAL312F, VAL336B, VAL344B, VAL373B, VAL376B, VAL423F, VAL43B, VAL71F, VAL73B, VAL97B, VAL98F
• B-G: ALA261G, ALA274G, ALA295B, ALA338B, ALA404B, ALA406B, ARG250G, ARG257G, ARG281B, ARG288B, ARG289B, ARG293B, ASN235G, ASN239G, ASN256G, ASN265G, ASP172B, ASP269G, ASP335B, ASP411B, GLN260G, GLN332B, GLN407B, GLN90G, GLU294B, GLY292B, GLY333B, GLY334B, ILE253G, ILE271G, LEU173G, LEU254G, LEU267G, LEU285B, LEU412B, LYS242G, LYS361B, PRO290B, PRO291B, PRO341B, SER174G, SER275G, SER337B, SER410B, THR264G, THR272G, THR331B, TYR296B, TYR339B, VAL268G, VAL336B
• B-N: ALA175N, ARG108B, ARG433N, ARG89N, ASP118B, ASP124B, GLN220B, GLN224B, GLN249N, GLU212N, GLU223B, GLU247N, GLU90N, GLY104B, GLY119B, GLY121B, GLY179N, LEU92N, LYS120B, LYS176N, PHE181N, PHE243N, PRO116B, PRO122B
• C-D: ALA135C, ALA159D, ALA15D, ALA19D, ALA228D, ALA264D, ALA270D, ALA278D, ALA311C, ALA312C, ALA314D, ALA338C, ALA379C, ALA389D, ALA397C, ALA51C, ALA65C, ARG106D, ARG130C, ARG141C, ARG142C, ARG166C, ARG190D, ARG192D, ARG199D, ARG229D, ARG260D, ARG274D, ARG288C, ARG289C, ARG293C, ARG306C, ARG310C, ARG337D, ARG375C, ARG400C, ARG408D, ARG412D, ARG60D, ARG72D, ARG92C, ASN195D, ASN223D, ASN28C, ASN343C, ASN47C, ASN48C, ASN67C, ASN95C, ASN97D, ASP104D, ASP196D, ASP22D, ASP299C, ASP315D, ASP316D, ASP319D, ASP335C, ASP349C, ASP394D, ASP65D, GLN132C, GLN165C, GLN221D, GLN263D, GLN351C, GLN385D, GLN398C, GLN43D, GLN50C, GLN72C, GLU105D, GLU189D, GLU193D, GLU224D, GLU267D, GLU294C, GLU309C, GLU318C, GLU341D, GLU401C, GLU52C, GLU53C, GLU68D, GLU69C, GLU74D, GLY137C, GLY158D, GLY160D, GLY162D, GLY164C, GLY186D, GLY188D, GLY18D, GLY194D, GLY220D, GLY273D, GLY280D, GLY292C, GLY298C, GLY31C, GLY343D, GLY350C, GLY370C, GLY377C, GLY392D, GLY426D, GLY44D, GLY45C, GLY66D, GLY69D, GLY71C, GLY73D, GLY74C, HIS24D, HIS304C, HIS455D, ILE103D, ILE138C, ILE17D, ILE20D, ILE275D, ILE344D, ILE345C, ILE347C, ILE388D, ILE390D, ILE427D, ILE49C, ILE75C, ILE95D, ILE96C, ILE96D, LEU139C, LEU197D, LEU209D, LEU217D, LEU271D, LEU272D, LEU27C, LEU287C, LEU303C, LEU307C, LEU308C, LEU342D, LEU371C, LEU391D, LEU394C, LEU46C, LEU46D, LEU54D, LEU66C, LEU68C, LEU70D, LYS134C, LYS163D, LYS202D, LYS313C, LYS317C, LYS386C, LYS393C, LYS45D, MET222D, MET393D, MET459D, MET64C, MET64D, PHE219D, PHE259D, PHE301C, PHE353C, PHE405C, PHE408C, PHE424D, PHE44C, PRO136C, PRO140C, PRO225D, PRO226D, PRO276D, PRO290C, PRO291C, PRO297C, PRO313D, PRO320D, PRO341C, PRO42D, PRO70C, SER143C, SER266D, SER269D, SER277D, SER284C, SER305C, SER315C, SER337C, SER340D, SER346C, SER372C, SER374C, SER378C, SER391C, SER410C, THR14D, THR164D, THR191D, THR342C, THR348C, THR41D, THR425D, THR58D, THR67D, TYR198D, TYR280C, TYR281D, TYR296C, TYR302C, TYR311D, TYR339C, TYR345D, TYR381D, TYR458D, VAL133C, VAL13D, VAL144C, VAL161D, VAL165D, VAL16D, VAL218D, VAL21D, VAL268D, VAL279D, VAL300C, VAL312D, VAL336C, VAL344C, VAL373C, VAL376C, VAL423D, VAL43C, VAL71D, VAL73C, VAL97C
• C-F: ALA119F, ALA125F, ALA131F, ALA145F, ALA216C, ALA235C, ALA238C, ALA241C, ALA242C, ALA278F, ALA279C, ALA286F, ALA295C, ALA323F, ALA327F, ALA32F, ALA331F, ALA356C, ALA35C, ALA360F, ALA361F, ALA371F, ALA406C, ALA41C, ALA51F, ARG108C, ARG173C, ARG212C, ARG274F, ARG281C, ARG288C, ARG289C, ARG293C, ARG295F, ARG356F, ARG364C, ARG42C, ARG60F, ARG82C, ASN35F, ASN433C, ASN57F, ASP111C, ASP118C, ASP120F, ASP172C, ASP272C, ASP288F, ASP316F, ASP319F, ASP330F, ASP335C, ASP349F, ASP352F, ASP359F, ASP369F, ASP38C, ASP400F, ASP81C, GLN127F, GLN174C, GLN210C, GLN217C, GLN220C, GLN224C, GLN245C, GLN282C, GLN282F, GLN293F, GLN308F, GLN332C, GLN365F, GLN375F, GLN379F, GLN399F, GLN407C, GLN434C, GLN52F, GLU126F, GLU240C, GLU294C, GLU294F, GLU29F, GLU330C, GLU355C, GLU357C, GLU376F, GLU395F, GLU398F, GLU424C, GLU56F, GLU86C, GLU88C, GLY119C, GLY150F, GLY151F, GLY176C, GLY209C, GLY273F, GLY280F, GLY290F, GLY333C, GLY334C, GLY362C, GLY37C, GLY39C, GLY409C, GLY55F, GLY79C, GLY81F, GLY87C, HIS118F, HIS328F, HIS53F, ILE117C, ILE117F, ILE153F, ILE233C, ILE275F, ILE296F, ILE33F, ILE363C, ILE387F, ILE40C, ILE62F, ILE83F, LEU144F, LEU218C, LEU244C, LEU272F, LEU283C, LEU285C, LEU285F, LEU286C, LEU287C, LEU291F, LEU292F, LEU30F, LEU317F, LEU329F, LEU34C, LEU34F, LEU351F, LEU357F, LEU358C, LEU358F, LEU378F, LEU384F, LEU391F, LEU396F, LEU420C, LEU460C, LEU54F, LEU77C, LEU83C, LYS120C, LYS152F, LYS211C, LYS275C, LYS300F, LYS354F, LYS361C, LYS373F, LYS382F, LYS431C, LYS85C, MET228C, MET289F, PHE124F, PHE156F, PHE326F, PHE359C, PHE408C, PRO116C, PRO116F, PRO121F, PRO122F, PRO243C, PRO276F, PRO283F, PRO290C, PRO291C, PRO31F, PRO320F, PRO322F, PRO350F, PRO82F, SER123F, SER128F, SER130F, SER213C, SER239C, SER269F, SER277F, SER284C, SER28F, SER353F, SER355F, SER372F, SER383F, SER397F, SER461C, SER80C, THR129F, THR175C, THR214C, THR237C, THR284F, THR287F, THR297F, THR298F, THR299F, THR318F, THR324F, THR325F, THR331C, THR332F, THR377F, THR380F, THR58F, TYR281F, TYR296C, TYR360C, TYR368F, TYR435C, VAL109C, VAL110C, VAL215C, VAL219C, VAL278C, VAL279F, VAL312F, VAL334F, VAL33C, VAL36C, VAL374F, VAL50F, VAL59F, VAL84C
• C-G: ALA1G, ALA274G, ALA295C, ALA338C, ALA406C, ARG288C, ARG289C, ARG293C, ASN131G, ASN265G, ASP112G, ASP269G, ASP335C, ASP411C, ASP80G, GLN332C, GLN407C, GLU266G, GLU294C, GLU5G, GLY273G, GLY292C, GLY333C, GLY334C, GLY409C, GLY82G, ILE270G, ILE271G, LEU119G, LEU285C, LEU412C, LEU83G, LYS113G, LYS115G, LYS417C, LYS4G, LYS81G, MET116G, PHE408C, PRO290C, PRO291C, SER275G, SER276G, SER337C, SER410C, THR272G, THR2G, TYR296C, VAL268G, VAL336C
• C-I: ALA53I, ASP411C, LYS417C, SER54I, TYR47I
• D-F: ALA389D, GLU395F, ILE387F, ILE390D, ILE390F, LEU391D, LEU391F
• D-G: ALA240G, ALA270D, ALA274G, ALA278D, ALA314D, ALA389D, ARG233G, ARG274D, ARG30G, ASN15G, ASP269G, ASP315D, ASP316D, ASP386D, ASP394D, ASP80G, GLU17G, GLU266G, GLU395D, GLU398D, GLY132G, GLY134G, GLY273D, GLY273G, GLY280D, GLY392D, GLY82G, ILE13G, ILE16G, ILE19G, ILE270G, ILE271G, ILE275D, ILE387D, ILE388D, ILE390D, LEU267G, LEU317D, LEU384D, LEU391D, LEU396D, LEU83G, LYS11G, LYS135G, LYS18G, LYS24G, LYS382D, LYS401D, LYS4G, LYS81G, MET237G, MET23G, MET393D, PRO276D, SER12G, SER275G, SER276G, SER277D, SER383D, THR20G, THR22G, THR272G, THR318D, TYR281D, VAL262G, VAL268G, VAL26G, VAL279D
• D-I: ASP41I, GLU398D
• E-G: ALA261G, ALA270E, ALA274G, ALA278E, ALA314E, ALA321E, ALA323E, ARG234G, ARG257G, ARG259G, ARG274E, ASN256G, ASN265G, ASP315E, ASP316E, ASP319E, ASP386E, GLN260G, GLY273E, GLY280E, ILE253G, ILE25G, ILE263G, ILE270G, ILE271G, ILE275E, ILE387E, ILE390E, LEU267G, LEU317E, LEU391E, LYS21G, LYS24G, PRO276E, PRO313E, PRO320E, PRO322E, SER252G, SER266E, SER275G, SER277E, SER28G, SER32G, THR264G, THR272G, THR29G, THR318E, TYR255G, TYR281E, VAL262G, VAL268G, VAL279E, VAL312E
• E-K: ARG108K, ARG89E, ASP118K, ASP226K, GLN220K, GLN224K, GLN249E, GLU212E, GLU223K, GLU246E, GLU247E, GLY119K, GLY121K, LEU113E, LYS112E, LYS120K, LYS189K, TYR242E
• E-N: ALA125E, ALA125N, ALA177N, ARG149E, ARG149N, ARG433N, ASP245E, ASP250N, GLN127N, GLN249N, GLU126E, GLU126N, GLU132E, GLU132N, GLU246E, GLU247E, GLU247N, GLU366N, GLY179N, GLY248E, GLY248N, GLY302N, HIS178N, LEU113E, LYS112E, LYS115E, LYS300E, LYS300N, LYS301E, LYS301N, LYS435E, LYS435N, LYS442N, SER128N, SER130E, SER130N, THR129E, THR129N, THR298N, THR299N, TYR242E
• E-T: GLU504T, LYS40E
• F-G: ALA1G, ALA236G, ALA240G, ALA244G, ALA278F, ALA314F, ALA389F, ALA92G, ARG120G, ARG233G, ARG250G, ARG257G, ARG274F, ARG96G, ARG9G, ASN239G, ASN243G, ASN265G, ASP246G, ASP269G, ASP316F, ASP386F, ASP394F, CYS84G, GLN117G, GLN385F, GLN399F, GLN90G, GLU17G, GLU395F, GLU398F, GLY245G, GLY273G, GLY280F, GLY392F, GLY82G, GLY85G, HIS88G, ILE13G, ILE16G, ILE248G, ILE271G, ILE275F, ILE387F, ILE388F, ILE390F, ILE87G, LEU118G, LEU391F, LEU396F, LEU402F, LEU83G, LYS113G, LYS242G, LYS401F, LYS81G, MET116G, MET237G, MET247G, MET393F, PRO276F, SER12G, SER241G, SER275G, SER276G, SER277F, SER397F, SER86G, SER89G, THR121G, THR20G, THR272G, THR318F, TYR251G, VAL268G, VAL279F
• G-H: ALA144G, ALA15H, ALA203G, ALA215G, ALA223G, ALA37G, ALA41G, ALA47G, ALA55G, ALA75H, ALA87H, ARG207G, ASN204G, ASN216G, ASN54G, ASP200G, ASP202G, ASP208G, ASP45G, ASP80H, CYS84H, GLN13H, GLN141G, GLN49G, GLN51H, GLN78H, GLN82H, GLU198G, GLU19H, GLU211G, GLU46G, GLU48G, GLU50H, GLU89H, GLY195G, GLY72H, GLY73H, HIS18H, HIS45H, ILE188G, ILE199G, ILE39G, ILE88H, LEU12H, LEU16H, LEU209G, LEU219G, LEU21H, LEU50G, LEU52H, LEU83H, LYS196G, LYS35H, LYS36G, LYS38G, LYS42G, LYS43G, LYS53G, MET44G, PHE140G, PHE14H, PHE194G, PHE197G, PHE210G, PHE51G, PHE74H, PRO138G, PRO17H, PRO206G, PRO47H, PRO79H, SER193G, SER23H, SER36H, SER40G, SER71H, SER81H, THR139G, THR20H, THR213G, THR220G, THR48H, THR76H, THR86H, TYR212G, TYR22H, TYR52G, VAL205G, VAL46H, VAL49H, VAL77H, VAL85H
• G-I: ALA11I, ALA12I, ALA137G, ALA144G, ALA147G, ALA18I, ALA215G, ALA32I, ALA42I, ALA53I, ARG120G, ARG207G, ARG37I, ASN124G, ASN125G, ASN131G, ASN15I, ASN204G, ASN216G, ASN36I, ASN49I, ASP112G, ASP136G, ASP148G, ASP208G, ASP41I, ASP80G, GLN141G, GLN19I, GLN39I, GLN46I, GLU142G, GLU211G, GLU55I, GLY111G, GLY132G, HIS122G, ILE107G, ILE110G, ILE126G, ILE130G, ILE133G, ILE146G, ILE59I, ILE8I, LEU119G, LEU128G, LEU145G, LEU14I, LEU150G, LEU151G, LEU209G, LEU214G, LEU219G, LYS115G, LYS127G, LYS135G, LYS149G, LYS33G, LYS48I, LYS61I, MET116G, MET154G, MET44G, PHE140G, PHE210G, PHE43I, PRO123G, PRO138G, PRO56I, PRO58I, SER129G, SER143G, SER152G, SER33I, SER38I, SER54I, SER9I, THR109G, THR139G, THR213G, THR31I, THR40I, THR45I, THR60I, TYR10I, TYR13I, TYR212G, TYR44I, TYR47I, VAL108G, VAL153G, VAL16I, VAL34I
• H-I: ALA106H, ALA11I, ALA121H, ALA123H, ALA124H, ALA12I, ALA17I, ALA18I, ALA20I, ALA87H, ALA90H, ARG118H, ARG22I, ARG37I, ASN15I, GLN126H, GLN19I, GLN30I, GLN51H, GLU122H, GLU128H, GLU19H, GLU28I, GLU50H, GLU89H, GLU94H, GLY72H, GLY73H, HIS18H, ILE101H, ILE125H, ILE21I, ILE70H, ILE88H, ILE8I, LEU104H, LEU105H, LEU130H, LEU133H, LEU14I, LEU16H, LEU29I, LEU52H, LEU53H, LYS102H, LYS35H, PHE69H, PHE74H, PHE96H, PRO17H, PRO54H, PRO92H, SER23I, SER33I, SER38I, SER71H, SER95H, SER97H, THR27I, THR86H, TYR10I, TYR13I, VAL127H, VAL129H, VAL16I, VAL34I
• J-K: ARG288K, PRO290J, PRO291J
• J-M: ALA119M, ALA125M, ALA131M, ALA216J, ALA235J, ALA238J, ALA241J, ALA242J, ALA270M, ALA278M, ALA279J, ALA286M, ALA295J, ALA323M, ALA327M, ALA32M, ALA331M, ALA356J, ALA35J, ALA360M, ALA361M, ALA36M, ALA371M, ALA404J, ALA406J, ALA41J, ALA51M, ARG108J, ARG173J, ARG212J, ARG274M, ARG281J, ARG288J, ARG289J, ARG293J, ARG295M, ARG356M, ARG364J, ARG42J, ARG60M, ARG82J, ASN35M, ASN433J, ASN57M, ASP111J, ASP118J, ASP120M, ASP172J, ASP272J, ASP288M, ASP316M, ASP319M, ASP330M, ASP335J, ASP349M, ASP352M, ASP359M, ASP369M, ASP38J, ASP400M, ASP78M, ASP81J, GLN127M, GLN174J, GLN210J, GLN217J, GLN220J, GLN224J, GLN245J, GLN27M, GLN282J, GLN282M, GLN293M, GLN332J, GLN365M, GLN375M, GLN379M, GLN399M, GLN428J, GLN434J, GLN52M, GLU126M, GLU240J, GLU294J, GLU294M, GLU29M, GLU330J, GLU357J, GLU376M, GLU395M, GLU398M, GLU49M, GLU56M, GLU86J, GLU88J, GLY119J, GLY150M, GLY151M, GLY176J, GLY209J, GLY273M, GLY280M, GLY290M, GLY292J, GLY333J, GLY334J, GLY362J, GLY37J, GLY39J, GLY55M, GLY79J, GLY80M, GLY81M, GLY87J, HIS118M, HIS328M, HIS53M, ILE117J, ILE153M, ILE233J, ILE275M, ILE296M, ILE33M, ILE363J, ILE387M, ILE40J, ILE62M, ILE83M, ILE9M, LEU144M, LEU218J, LEU244J, LEU272M, LEU283J, LEU285J, LEU285M, LEU286J, LEU287J, LEU291M, LEU292M, LEU30M, LEU317M, LEU329M, LEU34J, LEU34M, LEU351M, LEU357M, LEU358J, LEU358M, LEU378M, LEU384M, LEU396M, LEU460J, LEU54M, LEU77J, LEU83J, LYS120J, LYS152M, LYS177J, LYS211J, LYS275J, LYS300M, LYS354M, LYS361J, LYS373M, LYS382M, LYS431J, LYS85J, MET228J, MET289M, PHE124M, PHE156M, PHE25M, PHE326M, PHE359J, PRO116J, PRO116M, PRO121M, PRO122M, PRO243J, PRO276M, PRO283M, PRO290J, PRO291J, PRO31M, PRO320M, PRO322M, PRO350M, PRO82M, SER123M, SER128M, SER130M, SER213J, SER239J, SER269M, SER277M, SER284J, SER28M, SER353M, SER355M, SER372M, SER383M, SER397M, SER410J, SER80J, THR129M, THR175J, THR214J, THR221J, THR237J, THR284M, THR287M, THR297M, THR298M, THR299M, THR318M, THR324M, THR325M, THR331J, THR332M, THR377M, THR380M, THR58M, TYR281M, TYR296J, TYR360J, TYR368M, TYR435J, VAL109J, VAL110J, VAL215J, VAL219J, VAL278J, VAL279M, VAL312M, VAL334M, VAL33J, VAL36J, VAL374M, VAL50M, VAL59M, VAL84J
• J-N: ALA135J, ALA159N, ALA15N, ALA19N, ALA228N, ALA264N, ALA270N, ALA278N, ALA295J, ALA311J, ALA312J, ALA314N, ALA338J, ALA379J, ALA380J, ALA389N, ALA397J, ALA414J, ALA51J, ALA63N, ALA65J, ARG106N, ARG130J, ARG141J, ARG142J, ARG163J, ARG166J, ARG190N, ARG192N, ARG199N, ARG229N, ARG260N, ARG274N, ARG288J, ARG289J, ARG293J, ARG306J, ARG310J, ARG337N, ARG375J, ARG400J, ARG60N, ARG72N, ARG92J, ASN195N, ASN223N, ASN257N, ASN28J, ASN343J, ASN47J, ASN48J, ASN67J, ASN97N, ASP104N, ASP196N, ASP22N, ASP256N, ASP299J, ASP315N, ASP316N, ASP319N, ASP335J, ASP349J, ASP386N, ASP411J, ASP413J, ASP65N, GLN132J, GLN165J, GLN221N, GLN263N, GLN351J, GLN398J, GLN43N, GLN50J, GLN72J, GLU105N, GLU189N, GLU193N, GLU200N, GLU224N, GLU267N, GLU294J, GLU309J, GLU341N, GLU401J, GLU52J, GLU53J, GLU68N, GLU69J, GLU74N, GLY137J, GLY157N, GLY158N, GLY160N, GLY162J, GLY164J, GLY188N, GLY18N, GLY194N, GLY220N, GLY227N, GLY273N, GLY280N, GLY292J, GLY298J, GLY338N, GLY350J, GLY370J, GLY377J, GLY45J, GLY66N, GLY69N, GLY71J, GLY73N, GLY74J, HIS145J, HIS24N, HIS304J, ILE103N, ILE138J, ILE17N, ILE20N, ILE275N, ILE345J, ILE347J, ILE390N, ILE49J, ILE75J, ILE95N, ILE96J, ILE96N, LEU139J, LEU197N, LEU209N, LEU217N, LEU271N, LEU272N, LEU27J, LEU287J, LEU303J, LEU307J, LEU308J, LEU314J, LEU342N, LEU371J, LEU391N, LEU394J, LEU412J, LEU46J, LEU46N, LEU54N, LEU66J, LEU68J, LEU70N, LYS134J, LYS163N, LYS202N, LYS313J, LYS317J, LYS393J, MET222N, MET64J, MET64N, PHE219N, PHE259N, PHE301J, PHE405J, PHE44J, PRO136J, PRO140J, PRO225N, PRO226N, PRO276N, PRO290J, PRO291J, PRO297J, PRO313N, PRO42N, PRO70J, SER143J, SER266N, SER269N, SER284J, SER305J, SER315J, SER337J, SER346J, SER372J, SER374J, SER415J, THR14N, THR164N, THR191N, THR342J, THR348J, THR416J, THR41N, THR58N, THR67N, TYR198N, TYR280J, TYR281N, TYR296J, TYR302J, TYR311N, TYR339J, VAL133J, VAL13N, VAL144J, VAL16N, VAL21N, VAL268N, VAL279N, VAL300J, VAL312N, VAL336J, VAL344J, VAL369J, VAL373J, VAL376J, VAL43J, VAL71N, VAL73J, VAL97J
• J-P: ALA137P, ALA274P, ALA27P, ALA295J, ALA338J, ALA403J, ALA404J, ALA406J, ARG173J, ARG259P, ARG281J, ARG288J, ARG289J, ARG293J, ARG30P, ARG400J, ASN15P, ASP136P, ASP335J, ASP411J, ASP413J, GLN260P, GLU266P, GLU294J, GLU355J, GLU357J, GLU401J, GLU7P, GLY273P, GLY292J, GLY333J, GLY334J, ILE19P, ILE230P, ILE25P, ILE263P, ILE270P, ILE271P, LEU267P, LEU285J, LEU371J, LEU3P, LEU412J, LYS11P, LYS135P, LYS18P, LYS21P, LYS33P, LYS4P, LYS81P, MET23P, MET8P, PHE405J, PRO290J, PRO291J, SER275P, SER276P, SER337J, SER410J, THR22P, THR264P, THR272P, THR29P, THR342J, THR416J, TYR226P, TYR255P, TYR296J, TYR339J, TYR399J, VAL262P, VAL26P, VAL402J
• K-N: ALA119N, ALA125N, ALA131N, ALA148N, ALA207K, ALA216K, ALA235K, ALA238K, ALA241K, ALA242K, ALA278N, ALA279K, ALA286N, ALA295K, ALA323N, ALA327N, ALA32N, ALA331N, ALA35K, ALA361N, ALA36N, ALA41K, ALA51N, ARG149N, ARG173K, ARG212K, ARG274N, ARG281K, ARG288K, ARG289K, ARG293K, ARG295N, ARG32K, ARG356N, ARG364K, ARG42K, ARG60N, ARG82K, ASN35N, ASN57N, ASP111K, ASP118K, ASP120N, ASP172K, ASP288N, ASP316N, ASP319N, ASP330N, ASP335K, ASP359N, ASP38K, ASP78N, ASP81K, GLN127N, GLN174K, GLN210K, GLN217K, GLN220K, GLN224K, GLN245K, GLN27N, GLN282K, GLN282N, GLN293N, GLN332K, GLN379N, GLN434K, GLN52N, GLU126N, GLU132N, GLU223K, GLU240K, GLU294K, GLU294N, GLU29N, GLU330K, GLU49N, GLU56N, GLU86K, GLU88K, GLY119K, GLY150N, GLY151N, GLY209K, GLY273N, GLY280N, GLY290N, GLY333K, GLY334K, GLY37K, GLY39K, GLY55N, GLY80N, GLY81N, GLY87K, HIS118N, HIS24N, HIS328N, HIS53N, ILE117K, ILE233K, ILE275N, ILE296N, ILE33N, ILE40K, ILE83N, ILE9N, LEU218K, LEU244K, LEU272N, LEU283K, LEU285K, LEU285N, LEU286K, LEU287K, LEU291N, LEU292N, LEU30N, LEU317N, LEU329N, LEU34K, LEU34N, LEU351N, LEU357N, LEU54N, LEU77K, LEU83K, LYS120K, LYS152N, LYS211K, LYS275K, LYS354N, LYS85K, MET228K, MET289N, PHE124N, PHE326N, PRO116K, PRO116N, PRO121N, PRO122N, PRO243K, PRO276N, PRO283N, PRO290K, PRO291K, PRO31N, PRO320N, PRO322N, PRO82N, SER123N, SER128N, SER130N, SER213K, SER239K, SER269N, SER277N, SER284K, SER28N, SER80K, THR129N, THR214K, THR221K, THR237K, THR284N, THR287N, THR297N, THR298N, THR318N, THR324N, THR325N, THR331K, THR332N, THR58N, TYR281N, TYR296K, TYR360K, TYR368N, TYR435K, VAL109K, VAL110K, VAL215K, VAL219K, VAL278K, VAL279N, VAL33K, VAL362N, VAL36K, VAL50N, VAL59N, VAL84K
• K-O: ALA131K, ALA135K, ALA159O, ALA15O, ALA19O, ALA228O, ALA264O, ALA270O, ALA278O, ALA295K, ALA311K, ALA312K, ALA314O, ALA321O, ALA338K, ALA379K, ALA397K, ALA51K, ALA65K, ARG106O, ARG130K, ARG141K, ARG142K, ARG166K, ARG190O, ARG192O, ARG199O, ARG229O, ARG260O, ARG274O, ARG288K, ARG289K, ARG293K, ARG306K, ARG310K, ARG337O, ARG375K, ARG400K, ARG408O, ARG412O, ARG60O, ARG72O, ARG92K, ASN195O, ASN223O, ASN257O, ASN28K, ASN343K, ASN368K, ASN47K, ASN48K, ASN67K, ASN97O, ASP104O, ASP196O, ASP22O, ASP299K, ASP315O, ASP316O, ASP319O, ASP335K, ASP349K, ASP65O, GLN132K, GLN165K, GLN221O, GLN263O, GLN282O, GLN351K, GLN398K, GLN43O, GLN50K, GLN72K, GLU105O, GLU189O, GLU193O, GLU224O, GLU267O, GLU294K, GLU309K, GLU318K, GLU341O, GLU401K, GLU422O, GLU454O, GLU52K, GLU53K, GLU68O, GLU69K, GLU74O, GLY137K, GLY157O, GLY158O, GLY160O, GLY162O, GLY164K, GLY186O, GLY188O, GLY18O, GLY194O, GLY220O, GLY227O, GLY280O, GLY292K, GLY298K, GLY338O, GLY343O, GLY350K, GLY370K, GLY377K, GLY392O, GLY426O, GLY45K, GLY66O, GLY69O, GLY71K, GLY73O, GLY74K, HIS145K, HIS304K, HIS455O, ILE103O, ILE138K, ILE17O, ILE20O, ILE275O, ILE340K, ILE344O, ILE345K, ILE347K, ILE388O, ILE427O, ILE49K, ILE95O, ILE96K, ILE96O, LEU139K, LEU197O, LEU209O, LEU217O, LEU271O, LEU27K, LEU287K, LEU303K, LEU307K, LEU308K, LEU314K, LEU317O, LEU342O, LEU371K, LEU394K, LEU46K, LEU473O, LEU66K, LEU68K, LEU70O, LYS134K, LYS163O, LYS202O, LYS313K, LYS317K, LYS386K, LYS393K, LYS469O, MET222O, MET393O, MET459O, MET64O, PHE219O, PHE259O, PHE301K, PHE395K, PHE405K, PHE424O, PHE44K, PRO136K, PRO140K, PRO160K, PRO225O, PRO226O, PRO276O, PRO283O, PRO290K, PRO291K, PRO297K, PRO313O, PRO320O, PRO322O, PRO341K, PRO42O, PRO70K, SER143K, SER266O, SER269O, SER277O, SER305K, SER315K, SER337K, SER340O, SER346K, SER374K, SER378K, SER391K, SER415K, THR14O, THR164O, THR191O, THR318O, THR342K, THR348K, THR425O, THR58O, THR67O, TYR198O, TYR280K, TYR281O, TYR296K, TYR302K, TYR311O, TYR339K, TYR345O, TYR381O, TYR458O, VAL133K, VAL13O, VAL144K, VAL159K, VAL161O, VAL165O, VAL16O, VAL218O, VAL21O, VAL268O, VAL279O, VAL300K, VAL312O, VAL336K, VAL344K, VAL373K, VAL376K, VAL402K, VAL423O, VAL43K, VAL71O, VAL73K, VAL97K, VAL98O
• K-P: ALA236P, ALA261P, ALA274P, ALA295K, ALA338K, ALA404K, ALA406K, ARG250P, ARG257P, ARG281K, ARG288K, ARG289K, ARG293K, ASN235P, ASN239P, ASN243P, ASN249P, ASN256P, ASN265P, ASP238P, ASP246P, ASP269P, ASP335K, ASP411K, GLN260P, GLN332K, GLN407K, GLN90P, GLU294K, GLU357K, GLY292K, GLY333K, GLY334K, ILE253P, ILE271P, LEU254P, LEU267P, LEU285K, LEU412K, LYS242P, LYS361K, LYS93P, PHE175P, PHE405K, PRO290K, PRO291K, SER171P, SER174P, SER252P, SER275P, SER337K, SER86P, THR264P, THR272P, TYR296K, TYR339K, VAL170P, VAL268P, VAL336K
• K-T: ASP124K, LYS493T
• K-X: ASP465X, GLU29K, GLU464X, LYS91K
• L-M: ALA135L, ALA159M, ALA15M, ALA19M, ALA228M, ALA264M, ALA270M, ALA278M, ALA295L, ALA311L, ALA312L, ALA314M, ALA321M, ALA338L, ALA379L, ALA380L, ALA389L, ALA389M, ALA397L, ALA403L, ALA404L, ALA406L, ALA414L, ALA421M, ALA456M, ALA474M, ALA51L, ALA65L, ARG106M, ARG130L, ARG141L, ARG142L, ARG166L, ARG190M, ARG192M, ARG199M, ARG229M, ARG260M, ARG274M, ARG288L, ARG289L, ARG293L, ARG306L, ARG310L, ARG337M, ARG375L, ARG400L, ARG408M, ARG412M, ARG60M, ARG72M, ARG92L, ASN195M, ASN223M, ASN257M, ASN28L, ASN343L, ASN368L, ASN47L, ASN48L, ASN67L, ASN97M, ASP104M, ASP196M, ASP22M, ASP299L, ASP315M, ASP316M, ASP319M, ASP335L, ASP349L, ASP394M, ASP411L, ASP413L, ASP65M, GLN132L, GLN165L, GLN221M, GLN263M, GLN351L, GLN381L, GLN385M, GLN398L, GLN407L, GLN411M, GLN416M, GLN43M, GLN50L, GLN72L, GLU105M, GLU189M, GLU193M, GLU200M, GLU203M, GLU224M, GLU267M, GLU294L, GLU309L, GLU318L, GLU341M, GLU401L, GLU405M, GLU422M, GLU454M, GLU52L, GLU53L, GLU68M, GLU69L, GLU74M, GLY107M, GLY137L, GLY158M, GLY160M, GLY162M, GLY164L, GLY186M, GLY188M, GLY18M, GLY194M, GLY220M, GLY273M, GLY280M, GLY292L, GLY298L, GLY338M, GLY343M, GLY350L, GLY370L, GLY377L, GLY390L, GLY392M, GLY426M, GLY44M, GLY45L, GLY66M, GLY69M, GLY71L, GLY73M, GLY74L, HIS145L, HIS304L, HIS455M, ILE103M, ILE138L, ILE17M, ILE20M, ILE275M, ILE339M, ILE340L, ILE344M, ILE345L, ILE347L, ILE388M, ILE427M, ILE49L, ILE95M, ILE96L, ILE96M, LEU139L, LEU158L, LEU197M, LEU209M, LEU217M, LEU271M, LEU272M, LEU27L, LEU287L, LEU303L, LEU307L, LEU308L, LEU314L, LEU342M, LEU371L, LEU391M, LEU392L, LEU394L, LEU396L, LEU396M, LEU46L, LEU46M, LEU473M, LEU66L, LEU68L, LEU70M, LYS134L, LYS163M, LYS202M, LYS313L, LYS317L, LYS386L, LYS393L, LYS401M, LYS45M, LYS469M, MET222M, MET393M, MET459M, MET64L, MET64M, PHE219M, PHE259M, PHE301L, PHE353L, PHE395L, PHE405L, PHE424M, PHE44L, PRO136L, PRO140L, PRO160L, PRO225M, PRO226M, PRO276M, PRO290L, PRO291L, PRO297L, PRO313M, PRO320M, PRO322M, PRO341L, PRO417M, PRO42M, PRO453M, PRO70L, SER143L, SER266M, SER269M, SER305L, SER315L, SER337L, SER340M, SER346L, SER372L, SER374L, SER378L, SER391L, SER410L, SER415L, SER415M, THR14M, THR164M, THR191M, THR342L, THR348L, THR416L, THR419L, THR41M, THR425M, THR58M, THR67M, TYR198M, TYR280L, TYR281M, TYR302L, TYR311M, TYR339L, TYR345M, TYR381M, TYR399L, TYR458M, VAL133L, VAL13M, VAL144L, VAL159L, VAL161M, VAL165M, VAL16M, VAL218M, VAL21M, VAL268M, VAL279M, VAL300L, VAL312M, VAL336L, VAL344L, VAL369L, VAL373L, VAL376L, VAL402L, VAL404M, VAL423M, VAL43L, VAL71M, VAL73L, VAL97L
• L-O: ALA119O, ALA125O, ALA131O, ALA216L, ALA235L, ALA238L, ALA241L, ALA242L, ALA270O, ALA278O, ALA279L, ALA286O, ALA295L, ALA323O, ALA327O, ALA32O, ALA331O, ALA356L, ALA35L, ALA360O, ALA361O, ALA371O, ALA41L, ALA51O, ARG108L, ARG173L, ARG212L, ARG274O, ARG281L, ARG288L, ARG289L, ARG293L, ARG295O, ARG356O, ARG364L, ARG42L, ARG60O, ARG82L, ASN35O, ASN433L, ASN57O, ASP118L, ASP120O, ASP172L, ASP272L, ASP288O, ASP316O, ASP319O, ASP330O, ASP335L, ASP352O, ASP359O, ASP369O, ASP38L, ASP400O, ASP81L, GLN127O, GLN174L, GLN210L, GLN217L, GLN220L, GLN224L, GLN245L, GLN282L, GLN282O, GLN293O, GLN332L, GLN365O, GLN375O, GLN379O, GLN399O, GLN407L, GLN434L, GLN52O, GLU126O, GLU240L, GLU294L, GLU294O, GLU29O, GLU330L, GLU355L, GLU357L, GLU376O, GLU395O, GLU424L, GLU56O, GLU86L, GLU88L, GLY119L, GLY150O, GLY151O, GLY176L, GLY209L, GLY273O, GLY280O, GLY290O, GLY333L, GLY334L, GLY362L, GLY37L, GLY39L, GLY55O, GLY79L, GLY81O, GLY87L, HIS118O, HIS328O, HIS53O, ILE117L, ILE117O, ILE153O, ILE233L, ILE275O, ILE296O, ILE33O, ILE363L, ILE387O, ILE40L, ILE62O, ILE83O, LEU144O, LEU218L, LEU234O, LEU244L, LEU272O, LEU283L, LEU285L, LEU285O, LEU286L, LEU287L, LEU291O, LEU292O, LEU30O, LEU317O, LEU329O, LEU34L, LEU34O, LEU351O, LEU357O, LEU358L, LEU358O, LEU378O, LEU384O, LEU396O, LEU460L, LEU54O, LEU77L, LEU83L, LYS120L, LYS152O, LYS211L, LYS275L, LYS300O, LYS354O, LYS361L, LYS373O, LYS382O, LYS431L, LYS85L, MET228L, MET289O, PHE124O, PHE156O, PHE326O, PHE359L, PRO116L, PRO116O, PRO121O, PRO122O, PRO243L, PRO276O, PRO283O, PRO290L, PRO291L, PRO31O, PRO320O, PRO322O, PRO350O, PRO82O, SER123O, SER128O, SER130O, SER213L, SER239L, SER269O, SER277O, SER284L, SER28O, SER353O, SER355O, SER372O, SER383O, SER397O, SER80L, THR129O, THR175L, THR214L, THR221L, THR237L, THR284O, THR287O, THR297O, THR298O, THR299O, THR318O, THR324O, THR325O, THR331L, THR332O, THR377O, THR380O, THR58O, TYR281O, TYR296L, TYR360L, TYR368O, TYR435L, VAL109L, VAL110L, VAL215L, VAL219L, VAL278L, VAL279O, VAL312O, VAL334O, VAL33L, VAL36L, VAL374O, VAL50O, VAL59O, VAL84L
• L-P: ALA1P, ALA274P, ALA295L, ALA338L, ARG288L, ARG289L, ARG293L, ASN131P, ASN265P, ASP112P, ASP269P, ASP335L, ASP411L, ASP80P, GLN332L, GLN407L, GLU266P, GLU294L, GLU5P, GLY273P, GLY292L, GLY333L, GLY334L, GLY82P, ILE270P, ILE271P, LEU285L, LYS113P, LYS115P, LYS417L, MET116P, PRO290L, PRO291L, SER275P, SER276P, SER337L, SER410L, THR272P, THR2P, TYR296L, VAL268P, VAL336L
• M-O: ALA389M, ASP386O, GLU395O, GLY392M, ILE387O, ILE388M, ILE390M, ILE390O, LEU391M, LEU391O
• M-P: ALA240P, ALA244P, ALA270M, ALA274P, ALA278M, ALA314M, ALA389M, ARG233P, ARG274M, ARG30P, ARG9P, ASN15P, ASN265P, ASP112P, ASP269P, ASP315M, ASP316M, ASP319M, ASP386M, ASP394M, ASP80P, GLN385M, GLU266P, GLU395M, GLU398M, GLY273M, GLY273P, GLY280M, GLY392M, GLY82P, ILE13P, ILE16P, ILE19P, ILE270P, ILE271P, ILE275M, ILE387M, ILE388M, ILE390M, LEU267P, LEU317M, LEU384M, LEU391M, LEU396M, LEU3P, LEU83P, LYS113P, LYS11P, LYS135P, LYS382M, LYS401M, LYS4P, LYS81P, MET237P, MET23P, MET247P, MET8P, PRO276M, PRO313M, PRO320M, SER12P, SER275P, SER276P, SER277M, SER383M, SER397M, SER79P, THR20P, THR272P, THR2P, THR318M, TYR281M, VAL262P, VAL279M, VAL312M
• M-R: ASP41R, GLU398M
• N-P: ALA261P, ALA270N, ALA274P, ALA278N, ALA27P, ALA314N, ALA321N, ALA323N, ALA389N, ARG234P, ARG257P, ARG259P, ARG274N, ARG30P, ASN256P, ASN265P, ASP315N, ASP316N, ASP319N, ASP386N, GLN260P, GLN385N, GLU35P, GLU395N, GLY280N, ILE253P, ILE25P, ILE263P, ILE270P, ILE271P, ILE275N, ILE387N, ILE390N, LEU267P, LEU317N, LEU31P, LEU391N, LYS14P, LYS21P, LYS24P, LYS33P, LYS36P, LYS382N, PRO276N, PRO313N, PRO320N, PRO322N, SER252P, SER275P, SER277N, SER28P, SER32P, SER383N, THR22P, THR264P, THR272P, THR29P, THR318N, TYR255P, TYR281N, VAL262P, VAL268P, VAL26P, VAL279N, VAL312N
• O-P: ALA1P, ALA232P, ALA236P, ALA240P, ALA244P, ALA278O, ALA314O, ALA389O, ALA92P, ARG250P, ARG257P, ARG274O, ARG96P, ARG9P, ASN235P, ASN239P, ASN243P, ASN265P, ASP246P, ASP269P, ASP315O, ASP316O, ASP386O, ASP394O, CYS84P, GLN385O, GLN90P, GLU17P, GLU341O, GLU395O, GLU398O, GLY245P, GLY273P, GLY280O, GLY338O, GLY392O, GLY82P, GLY85P, HIS88P, ILE13P, ILE16P, ILE248P, ILE271P, ILE275O, ILE387O, ILE388O, ILE390O, ILE87P, LEU391O, LEU396O, LEU83P, LYS113P, LYS242P, LYS401O, LYS81P, LYS93P, MET116P, MET237P, MET23P, MET247P, MET393O, PRO276O, SER241P, SER275P, SER276P, SER277O, SER397O, SER86P, SER89P, THR20P, THR272P, THR318O, TYR251P, TYR281O, VAL268P, VAL279O
• O-X: LYS176X, LYS40O
• P-Q: ALA144P, ALA15Q, ALA203P, ALA37P, ALA41P, ALA47P, ALA55P, ALA75Q, ALA87Q, ALA90Q, ARG207P, ASN204P, ASN216P, ASN54P, ASP200P, ASP202P, ASP208P, ASP45P, ASP80Q, CYS84Q, GLN13Q, GLN141P, GLN49P, GLN51Q, GLN78Q, GLN82Q, GLU19Q, GLU211P, GLU46P, GLU48P, GLU50Q, GLU56P, GLU89Q, GLY72Q, GLY73Q, HIS18Q, ILE188P, ILE39P, ILE88Q, LEU16Q, LEU209P, LEU219P, LEU50P, LEU52Q, LEU83Q, LYS35Q, LYS36P, LYS42P, LYS43P, LYS53P, MET44P, PHE140P, PHE14Q, PHE210P, PHE51P, PHE74Q, PRO138P, PRO17Q, PRO206P, PRO47Q, PRO79Q, SER36Q, SER40P, SER71Q, SER81Q, THR139P, THR201P, THR213P, THR220P, THR48Q, THR76Q, THR86Q, TYR212P, VAL205P, VAL46Q, VAL49Q, VAL77Q, VAL85Q
• P-R: ALA11R, ALA12R, ALA137P, ALA144P, ALA147P, ALA17R, ALA18R, ALA20R, ALA215P, ALA32R, ALA42R, ARG207P, ARG37R, ASN131P, ASN15R, ASN204P, ASN216P, ASN36R, ASP136P, ASP148P, ASP208P, ASP41R, GLN141P, GLN19R, GLN39R, GLN46R, GLU142P, GLU211P, GLY132P, ILE110P, ILE130P, ILE133P, ILE146P, LEU128P, LEU145P, LEU14R, LEU151P, LEU209P, LEU214P, LEU35R, LYS115P, LYS127P, LYS135P, LYS149P, LYS33P, PHE140P, PHE210P, PHE43R, PRO138P, SER129P, SER143P, SER33R, SER38R, THR139P, THR213P, THR40R, THR45R, TYR10R, TYR13R, TYR212P, TYR44R, TYR47R, VAL153P, VAL16R, VAL34R
• Q-R: ALA11R, ALA17R, ALA18R, ALA20R, ALA87Q, ALA90Q, ARG22R, ARG37R, ASN132Q, ASN15R, GLN126Q, GLN19R, GLN51Q, GLN98Q, GLU128Q, GLU89Q, GLY55Q, GLY72Q, GLY73Q, HIS18Q, ILE101Q, ILE21R, ILE70Q, ILE88Q, LEU105Q, LEU130Q, LEU133Q, LEU14R, LEU52Q, LEU53Q, LYS102Q, PHE69Q, PHE74Q, PRO17Q, PRO54Q, SER33R, SER71Q, SER97Q, THR27R, THR86Q, TYR10R, TYR13R, VAL127Q, VAL129Q, VAL16R, VAL34R
• S-V: ARG173S, ARG212S, ARG274V, ARG281S, ARG356V, ARG82S, ASN57V, ASP330V, ASP352V, ASP38S, ASP81S, GLN217S, GLN282S, GLU126V, GLU240S, GLU294V, GLU29V, GLU357S, GLU56V, GLU86S, GLU88S, HIS118V, HIS328V, HIS53V, LEU30V, LYS152V, LYS211S, LYS354V, LYS382V, LYS85S, SER277V, THR287V, VAL36S
• S-W: ALA51S, ARG130S, ARG141S, ARG142S, ARG166S, ARG190W, ARG192W, ARG199W, ARG375S, ARG72W, ASN195W, ASP196W, ASP22W, ASP299S, ASP349S, ASP65W, GLU193W, GLU224W, GLU267W, GLU309S, GLU52S, GLU68W, GLU69S, GLY45S, GLY69W, ILE138S, LEU46S, LEU68S, LEU70W, LYS134S, SER346S, VAL16W
• S-Y: ARG259Y, ARG293S, ARG30Y, ASP136Y, ASP335S, ASP411S, GLU266Y, GLU294S, GLU7Y, LYS33Y
• T-W: ARG173T, ARG212T, ARG274W, ARG82T, ASN57W, ASP330W, ASP38T, ASP81T, GLN282T, GLN52W, GLU126W, GLU240T, GLU294W, GLU56W, GLU86T, HIS118W, HIS328W, HIS53W, LYS152W, LYS211T, LYS85T, PHE326W, THR287W, VAL36T
• T-X: ALA51T, ARG130T, ARG141T, ARG142T, ARG166T, ARG190X, ARG192X, ARG199X, ARG289T, ARG293T, ARG375T, ARG72X, ASN195X, ASP196X, ASP22X, ASP299T, ASP315X, ASP316X, ASP319X, ASP335T, ASP349T, ASP65X, GLU105X, GLU193X, GLU224X, GLU267X, GLU309T, GLU52T, GLU68X, GLU69T, ILE345T, ILE347T, LEU68T, LEU70X, LYS134T, LYS317T, SER337T, THR191X, VAL16X
• T-Y: ARG257Y, ASP335T, ASP411T, GLU294T, LYS93Y
• U-V: ALA51U, ARG130U, ARG141U, ARG142U, ARG166U, ARG190V, ARG192V, ARG199V, ARG375U, ARG400U, ARG72V, ASP196V, ASP22V, ASP299U, ASP349U, ASP65V, GLN72U, GLU193V, GLU224V, GLU267V, GLU309U, GLU341V, GLU401U, GLU52U, GLU68V, GLU69U, GLY45U, GLY69V, LEU68U, LEU70V, LYS134U, SER346U, VAL16V
• U-X: ARG173U, ARG212U, ARG274X, ARG288U, ARG356X, ARG364U, ARG82U, ASN57X, ASP120X, ASP172U, ASP288X, ASP330X, ASP352X, ASP38U, ASP81U, GLN217U, GLN282U, GLU126X, GLU240U, GLU294X, GLU29X, GLU357U, GLU56X, GLU86U, GLU88U, GLY273X, HIS118X, HIS328X, HIS53X, LEU351X, LYS152X, LYS211U, LYS354X, LYS382X, LYS85U, THR287X, TYR360U, TYR368X, VAL36U
• U-Y: ARG293U, ASP112Y, ASP269Y, ASP335U, ASP411U, GLU266Y, GLU294U, GLU5Y, LYS113Y, LYS4Y
• V-Y: ASP315V, ASP316V, ASP386V, ASP394V, LYS11Y, LYS135Y, LYS4Y, LYS81Y
• W-Y: ARG257Y, ARG259Y, ASP238Y, ASP316W, ASP319W, ASP386W, THR264Y, VAL279W
• X-Y: ARG120Y, ARG9Y, ASP386X, GLU398X
• Y-1: ASP148Y, SER91