2HJR

crystal structure of cryptosporidium parvum malate dehydrogenase

• Total interactions analyzed: 66
• Total true interactions: 23
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 120
  • Norm. En. per Res.: -3.5898
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-105.3441	-30.3889	-295.043	-430.776	120	19	11	12899	3	20	25
A-C	-57.3002	-10.6963	-75.3147	-143.3112	48	4	0	3957	2	32	35
A-D	-87.2634	-9.9401	-520.318	-617.5215	186	19	20	22453	0	32	38
B-C	-92.6311	-0.3012	-529.25	-622.1823	191	22	21	22451	0	32	38
B-D	-58.4475	-6.7922	-77.2234	-142.4631	50	4	0	3938	1	32	35
B-E	0.0	0.0	-1.4626	-1.4626	13	0	0	149	0	0	0
B-F	-6.9915	-12.2958	-58.8306	-78.1179	39	2	0	2672	0	7	12
C-D	-63.4205	-28.8435	-287.681	-379.945	120	10	10	12456	3	19	23
C-E	0.0	0.0	-0.003	-0.003	2	0	0	5	0	0	0
C-J	0.0	-12.1932	-49.0231	-61.2163	32	1	0	2333	1	6	9
D-J	0.0	0.0	-0.896	-0.896	9	0	0	126	0	0	0
E-F	-81.2164	-26.7739	-290.852	-398.8423	121	13	11	12815	2	19	24
E-G	-96.5437	-9.8906	-510.012	-616.4463	187	25	20	22347	0	32	38
E-H	-50.0792	-6.3873	-72.5747	-129.0411	50	4	0	3933	2	32	35
F-G	-59.4768	-11.5725	-71.314	-142.3633	49	4	0	3896	2	32	35
F-H	-86.5989	-8.235	-501.43	-596.2639	187	18	21	21989	0	32	37
G-H	-82.7268	-20.3927	-293.069	-396.1885	121	15	11	12837	3	20	24
I-J	-108.8774	-30.9407	-272.45	-412.268	121	20	10	12614	3	19	23
I-K	-61.6022	-14.4492	-74.7644	-150.8159	51	4	0	3845	2	32	35
I-L	-92.6878	-8.1006	-521.068	-621.8564	188	23	21	22321	0	32	37
J-K	-87.6038	-8.2576	-523.499	-619.3604	186	19	21	22126	0	32	37
J-L	-58.2686	-6.1475	-76.9996	-141.4157	51	5	0	4012	2	32	35
K-L	-82.9384	-17.7452	-309.964	-410.6476	122	15	10	13288	2	20	26

Interface residues

• A-B: ALA181A, ALA181B, ALA252A, ALA252B, ALA256A, ALA256B, ARG165A, ARG165B, ASN300A, ASN300B, ASP178A, ASP178B, ASP207A, ASP207B, ASP260A, ASP260B, ASP295A, ASP295B, GLN211A, GLN211B, GLN255A, GLN255B, GLN274A, GLU210A, GLU210B, GLU294A, GLU294B, GLY173A, GLY173B, GLY201A, GLY201B, GLY202A, GLY202B, ILE182A, ILE182B, ILE200A, ILE200B, ILE203A, ILE203B, ILE288A, ILE288B, ILE298A, ILE298B, LEU172A, LEU172B, LEU194A, LEU194B, LEU204A, LEU204B, LEU205A, LEU205B, LEU265A, LEU265B, LEU301A, LEU301B, LYS175A, LYS175B, LYS213A, LYS213B, LYS259A, LYS259B, LYS262A, LYS262B, MET253A, PHE208A, PHE208B, PRO176A, PRO176B, PRO285A, PRO285B, SER161A, SER161B, SER169A, SER169B, SER177A, SER177B, SER180A, SER180B, SER196A, SER196B, SER197A, SER197B, SER206A, SER206B, SER261A, SER261B, SER263A, SER263B, THR195A, THR195B, THR199A, THR199B, TYR275A, TYR275B, VAL174A, VAL174B, VAL179A, VAL179B, VAL183A, VAL183B, VAL184A, VAL184B, VAL198A, VAL198B, VAL264A, VAL264B, VAL266A, VAL266B, VAL284A, VAL284B, VAL286A, VAL286B, VAL287A, VAL287B, VAL296A, VAL296B, VAL297A, VAL297B, VAL299A, VAL299B
• A-C: ALA256A, ALA256C, ALA69A, ALA69C, ARG14A, ARG14C, ASP260A, ASP260C, ASP37A, ASP37C, ASP40A, ASP40C, GLN255A, GLN255C, GLY39A, GLY39C, GLY66A, GLY66C, LEU258A, LEU258C, LEU33A, LEU33C, LEU38A, LEU38C, LYS15A, LYS15C, LYS259A, LYS259C, LYS262A, LYS262C, LYS290A, LYS290C, LYS36A, LYS36C, LYS70A, LYS70C, MET13A, MET13C, PRO68A, PRO68C, SER261A, SER261C, SER263A, SER263C, SER67A, SER67C, TYR257A, TYR257C
• A-D: ALA162A, ALA162D, ALA22A, ALA22D, ALA242A, ALA242D, ALA245A, ALA245D, ALA247A, ALA247D, ALA248A, ALA248D, ALA250A, ALA250D, ALA252A, ALA252D, ALA30A, ALA30D, ALA55A, ALA55D, ALA63A, ALA63D, ALA69A, ALA69D, ARG14A, ARG14D, ARG163A, ARG163D, ARG165A, ARG165D, ARG170A, ARG170D, ASN167A, ASN167D, ASN59A, ASN59D, ASN75A, ASN75D, ASP160A, ASP160D, ASP178A, ASP178D, ASP37A, ASP37D, ASP57A, ASP57D, CYS166A, CYS166D, CYS61A, CYS61D, GLN24A, GLN24D, GLN35A, GLN35D, GLN52A, GLN52D, GLU232A, GLU232D, GLU235A, GLU235D, GLU48A, GLU48D, GLY157A, GLY157D, GLY173A, GLY173D, GLY229A, GLY229D, GLY230A, GLY230D, GLY231D, GLY23A, GLY23D, GLY240D, GLY26A, GLY26D, GLY49A, GLY49D, GLY53A, GLY53D, GLY66A, GLY66D, GLY73A, GLY73D, HIS60A, HIS60D, ILE233A, ILE233D, ILE25A, ILE25D, ILE29A, ILE29D, ILE47A, ILE47D, ILE65A, ILE65D, ILE71A, ILE71D, LEU159A, LEU159D, LEU236A, LEU236D, LEU237A, LEU237D, LEU265A, LEU265D, LEU31A, LEU31D, LEU32A, LEU32D, LEU56A, LEU56D, LEU58A, LEU58D, LEU64A, LEU64D, LYS175A, LYS175D, LYS225A, LYS225D, LYS238A, LYS238D, LYS36A, LYS36D, LYS54A, LYS54D, LYS70A, LYS70D, MET155A, MET155D, MET253A, MET253D, MET43A, MET43D, MET62A, MET62D, PHE164A, PHE164D, PHE228A, PHE228D, PHE243A, PHE243D, PHE72A, PHE72D, PRO176A, PRO176D, PRO246A, PRO246D, PRO51A, PRO51D, PRO68A, PRO68D, SER161A, SER161D, SER169A, SER169D, SER177A, SER177D, SER241A, SER241D, SER249A, SER249D, SER27A, SER27D, SER67A, SER67D, THR226A, THR226D, THR239A, THR239D, THR28A, THR28D, TYR244A, TYR244D, VAL158A, VAL158D, VAL174A, VAL174D, VAL179A, VAL179D, VAL234A, VAL234D, VAL251A, VAL251D, VAL50A, VAL50D
• B-C: ALA162B, ALA162C, ALA22B, ALA22C, ALA242B, ALA242C, ALA245B, ALA245C, ALA247B, ALA247C, ALA248B, ALA248C, ALA250B, ALA250C, ALA252B, ALA252C, ALA30B, ALA30C, ALA55B, ALA55C, ALA63B, ALA63C, ALA69B, ALA69C, ARG14B, ARG14C, ARG163B, ARG163C, ARG165B, ARG165C, ARG170B, ARG170C, ASN167B, ASN167C, ASN59B, ASN59C, ASN75B, ASN75C, ASP160B, ASP160C, ASP178B, ASP178C, ASP37B, ASP37C, ASP40B, ASP40C, ASP57B, ASP57C, CYS166B, CYS166C, CYS61B, CYS61C, GLN24B, GLN24C, GLN35B, GLN35C, GLN52B, GLN52C, GLU232B, GLU232C, GLU235B, GLU235C, GLU48B, GLU48C, GLY157B, GLY157C, GLY173B, GLY173C, GLY229B, GLY229C, GLY230B, GLY230C, GLY231B, GLY231C, GLY23B, GLY23C, GLY240C, GLY26B, GLY26C, GLY49B, GLY49C, GLY53B, GLY53C, GLY66B, GLY66C, GLY73B, GLY73C, HIS60B, HIS60C, ILE233B, ILE233C, ILE25B, ILE25C, ILE29B, ILE29C, ILE47B, ILE47C, ILE65B, ILE65C, ILE71B, ILE71C, LEU159B, LEU159C, LEU236B, LEU236C, LEU237B, LEU237C, LEU265B, LEU265C, LEU31B, LEU31C, LEU32B, LEU32C, LEU56B, LEU56C, LEU58B, LEU58C, LEU64B, LEU64C, LYS175B, LYS175C, LYS225B, LYS225C, LYS238B, LYS238C, LYS36B, LYS36C, LYS54B, LYS54C, LYS70B, LYS70C, MET155B, MET155C, MET253B, MET253C, MET43B, MET43C, MET62B, MET62C, PHE164B, PHE164C, PHE228B, PHE228C, PHE243B, PHE243C, PHE72B, PHE72C, PRO176B, PRO176C, PRO246B, PRO246C, PRO51B, PRO51C, PRO68B, PRO68C, SER161B, SER161C, SER169B, SER169C, SER177B, SER177C, SER241B, SER241C, SER249B, SER249C, SER27B, SER27C, SER67B, SER67C, THR226B, THR226C, THR239B, THR239C, THR28B, THR28C, TYR244B, TYR244C, TYR42B, VAL158B, VAL158C, VAL174B, VAL174C, VAL179B, VAL179C, VAL234B, VAL234C, VAL251B, VAL251C, VAL41B, VAL50B, VAL50C
• B-D: ALA256B, ALA256D, ALA69B, ALA69D, ARG14B, ARG14D, ASN291B, ASP260B, ASP260D, ASP37B, ASP37D, ASP40B, ASP40D, GLN255B, GLN255D, GLY289D, GLY39B, GLY39D, GLY66B, GLY66D, LEU258B, LEU258D, LEU33B, LEU33D, LEU38B, LEU38D, LYS15B, LYS15D, LYS259B, LYS259D, LYS262B, LYS262D, LYS290B, LYS290D, LYS36B, LYS36D, LYS70B, LYS70D, MET13B, MET13D, PRO68B, PRO68D, SER261B, SER261D, SER263B, SER263D, SER67B, SER67D, TYR257B, TYR257D
• B-E: ASN276E, ASN278E, ASN279E, ASN300E, GLU48B, GLY273E, ILE298E, ILE46B, ILE47B, LEU301E, LYS109B, LYS306E, THR272E
• B-F: ALA108B, ARG100B, ARG94B, ASN107B, ASN220F, ASN97B, ASP102B, ASP207F, ASP322B, GLN211F, GLN218F, GLU210F, GLU221F, GLY212F, HIS216F, ILE110B, ILE214F, ILE219F, LEU103B, LEU104B, LEU326B, LYS109B, LYS213F, LYS224F, LYS225F, LYS95B, MET98B, PHE208F, PRO93B, PRO96B, SER101B, SER206F, SER217F, THR105B, THR215F, THR99B, VAL106B, VAL209F, VAL92B
• C-D: ALA181C, ALA181D, ALA252C, ALA252D, ALA256C, ALA256D, ARG165C, ARG165D, ASN300C, ASN300D, ASP178C, ASP178D, ASP207C, ASP207D, ASP260C, ASP260D, ASP295C, ASP295D, GLN211C, GLN211D, GLN255C, GLN255D, GLN274C, GLU210C, GLU210D, GLU294C, GLU294D, GLY173C, GLY173D, GLY201C, GLY201D, GLY202C, GLY202D, ILE182C, ILE182D, ILE200C, ILE200D, ILE203C, ILE203D, ILE288C, ILE288D, ILE298C, ILE298D, LEU172C, LEU172D, LEU194C, LEU194D, LEU204C, LEU204D, LEU205C, LEU205D, LEU265C, LEU265D, LEU301C, LEU301D, LYS175C, LYS175D, LYS213C, LYS213D, LYS259C, LYS259D, LYS262C, LYS262D, PHE208C, PHE208D, PRO176C, PRO176D, PRO285C, PRO285D, SER161C, SER161D, SER169C, SER169D, SER177C, SER177D, SER180C, SER180D, SER196C, SER196D, SER197C, SER197D, SER206C, SER206D, SER261C, SER261D, SER263C, SER263D, THR195C, THR195D, THR199C, THR199D, TYR275C, TYR275D, VAL174C, VAL174D, VAL179C, VAL179D, VAL183C, VAL183D, VAL184C, VAL184D, VAL198C, VAL198D, VAL209C, VAL264C, VAL264D, VAL266C, VAL266D, VAL284C, VAL284D, VAL286C, VAL286D, VAL287C, VAL287D, VAL296C, VAL296D, VAL297C, VAL297D, VAL299C, VAL299D
• C-E: LYS238C, THR272E
• C-J: ALA108J, ARG94J, ASN107J, ASN97J, ASP102J, ASP207C, ASP322J, GLN211C, GLN218C, GLU210C, GLY212C, HIS216C, ILE110J, ILE214C, LEU103J, LEU104J, LEU326J, LYS109J, LYS213C, LYS95J, MET98J, PHE208C, SER101J, SER206C, SER217C, SER325J, THR105J, THR215C, THR99J, VAL106J, VAL209C, VAL92J
• D-J: ASN276D, ASN278D, ASN300D, GLU48J, GLY273D, ILE298D, ILE46J, LYS109J, LYS306D
• E-F: ALA181E, ALA181F, ALA252E, ALA252F, ALA256E, ALA256F, ARG165E, ASN300E, ASN300F, ASP178E, ASP178F, ASP207E, ASP207F, ASP260E, ASP260F, ASP295E, ASP295F, GLN211E, GLN211F, GLN255E, GLN255F, GLN274E, GLU210E, GLU210F, GLU294E, GLU294F, GLY173E, GLY173F, GLY201E, GLY201F, GLY202E, GLY202F, GLY212E, GLY212F, ILE182E, ILE182F, ILE200E, ILE200F, ILE203E, ILE203F, ILE288E, ILE288F, ILE298E, ILE298F, LEU172E, LEU172F, LEU194E, LEU194F, LEU204E, LEU204F, LEU205E, LEU205F, LEU265E, LEU265F, LEU301E, LEU301F, LYS175E, LYS175F, LYS213E, LYS213F, LYS259E, LYS259F, LYS262E, LYS262F, PHE208E, PHE208F, PRO176E, PRO176F, PRO285E, PRO285F, SER161E, SER161F, SER169E, SER169F, SER177E, SER177F, SER180E, SER180F, SER196E, SER196F, SER197E, SER197F, SER206E, SER206F, SER261E, SER261F, SER263E, SER263F, THR195E, THR195F, THR199E, THR199F, TYR275E, TYR275F, VAL174E, VAL174F, VAL179E, VAL179F, VAL183E, VAL183F, VAL184E, VAL184F, VAL198E, VAL198F, VAL209E, VAL209F, VAL264E, VAL264F, VAL266E, VAL266F, VAL284E, VAL286E, VAL286F, VAL287E, VAL287F, VAL296E, VAL296F, VAL297E, VAL297F, VAL299E, VAL299F
• E-G: ALA162E, ALA162G, ALA22E, ALA22G, ALA242E, ALA242G, ALA245E, ALA245G, ALA247E, ALA247G, ALA248E, ALA248G, ALA250E, ALA250G, ALA252E, ALA252G, ALA30E, ALA30G, ALA55E, ALA55G, ALA63E, ALA63G, ALA69E, ALA69G, ARG14E, ARG14G, ARG163E, ARG163G, ARG165E, ARG165G, ARG170E, ARG170G, ASN167E, ASN167G, ASN59E, ASN59G, ASN75E, ASN75G, ASP160E, ASP160G, ASP178E, ASP178G, ASP37E, ASP37G, ASP57E, ASP57G, CYS166E, CYS166G, CYS61E, CYS61G, GLN24E, GLN24G, GLN35E, GLN35G, GLN52E, GLN52G, GLU232E, GLU232G, GLU235E, GLU235G, GLU48E, GLU48G, GLY157E, GLY157G, GLY173E, GLY173G, GLY229E, GLY229G, GLY230E, GLY230G, GLY231E, GLY231G, GLY23E, GLY23G, GLY240E, GLY26E, GLY26G, GLY49E, GLY49G, GLY53E, GLY53G, GLY66E, GLY66G, GLY73E, GLY73G, HIS60E, HIS60G, ILE233E, ILE233G, ILE25E, ILE25G, ILE29E, ILE29G, ILE47E, ILE47G, ILE65E, ILE65G, ILE71E, ILE71G, LEU159E, LEU159G, LEU236E, LEU236G, LEU237E, LEU237G, LEU265E, LEU265G, LEU31E, LEU31G, LEU32E, LEU32G, LEU56E, LEU56G, LEU58E, LEU58G, LEU64E, LEU64G, LYS175E, LYS175G, LYS225E, LYS225G, LYS238E, LYS238G, LYS36E, LYS36G, LYS54E, LYS54G, LYS70E, LYS70G, MET155E, MET155G, MET253E, MET253G, MET43E, MET43G, MET62E, MET62G, PHE164E, PHE164G, PHE228E, PHE228G, PHE243E, PHE243G, PHE72E, PHE72G, PRO176E, PRO176G, PRO246E, PRO246G, PRO51E, PRO51G, PRO68E, PRO68G, SER161E, SER161G, SER169E, SER169G, SER177E, SER177G, SER241E, SER241G, SER249E, SER249G, SER27E, SER27G, SER67E, SER67G, THR226E, THR226G, THR239E, THR239G, THR28E, THR28G, TYR244E, TYR244G, VAL158E, VAL158G, VAL174E, VAL174G, VAL179E, VAL179G, VAL234E, VAL234G, VAL251E, VAL251G, VAL50E, VAL50G
• E-H: ALA256E, ALA256H, ALA69E, ALA69H, ARG14E, ARG14H, ASN291E, ASN291H, ASP260E, ASP260H, ASP37E, ASP37H, ASP40E, ASP40H, GLN255E, GLN255H, GLY39E, GLY39H, GLY66E, GLY66H, LEU258E, LEU258H, LEU33E, LEU33H, LEU38E, LEU38H, LYS15E, LYS15H, LYS259E, LYS259H, LYS262E, LYS262H, LYS290E, LYS290H, LYS36E, LYS36H, LYS70E, LYS70H, MET13E, MET13H, PRO68E, PRO68H, SER261E, SER261H, SER263E, SER263H, SER67E, SER67H, TYR257E, TYR257H
• F-G: ALA256F, ALA256G, ALA69F, ALA69G, ARG14F, ARG14G, ASN291F, ASP260F, ASP260G, ASP37F, ASP37G, ASP40F, ASP40G, GLN255F, GLN255G, GLY39F, GLY39G, GLY66F, GLY66G, LEU258F, LEU258G, LEU33F, LEU33G, LEU38F, LEU38G, LYS15F, LYS15G, LYS259F, LYS259G, LYS262F, LYS262G, LYS290F, LYS290G, LYS36F, LYS36G, LYS70F, LYS70G, MET13F, MET13G, PRO68F, PRO68G, SER261F, SER261G, SER263F, SER263G, SER67F, SER67G, TYR257F, TYR257G
• F-H: ALA162F, ALA162H, ALA22F, ALA22H, ALA242F, ALA242H, ALA245F, ALA245H, ALA247F, ALA247H, ALA248F, ALA248H, ALA250F, ALA250H, ALA252F, ALA252H, ALA30F, ALA30H, ALA55F, ALA55H, ALA63F, ALA63H, ALA69F, ALA69H, ARG14F, ARG14H, ARG163F, ARG163H, ARG165F, ARG165H, ARG170F, ARG170H, ASN167F, ASN167H, ASN59F, ASN59H, ASN75F, ASN75H, ASP160F, ASP160H, ASP178F, ASP178H, ASP37F, ASP57F, ASP57H, CYS166F, CYS166H, CYS61F, CYS61H, GLN24F, GLN24H, GLN35F, GLN35H, GLN52F, GLN52H, GLU232F, GLU232H, GLU235F, GLU235H, GLU48F, GLU48H, GLY157F, GLY157H, GLY173F, GLY173H, GLY229F, GLY229H, GLY230F, GLY230H, GLY231F, GLY231H, GLY23F, GLY23H, GLY240F, GLY240H, GLY26F, GLY26H, GLY49F, GLY49H, GLY53F, GLY53H, GLY66F, GLY66H, GLY73F, GLY73H, HIS60F, HIS60H, ILE233F, ILE233H, ILE25F, ILE25H, ILE29F, ILE29H, ILE47F, ILE47H, ILE65F, ILE65H, ILE71F, ILE71H, LEU159F, LEU159H, LEU236F, LEU236H, LEU237F, LEU237H, LEU265F, LEU265H, LEU31F, LEU31H, LEU32F, LEU32H, LEU56F, LEU56H, LEU58F, LEU58H, LEU64F, LEU64H, LYS175F, LYS175H, LYS225F, LYS225H, LYS238F, LYS238H, LYS36F, LYS36H, LYS54F, LYS54H, LYS70F, LYS70H, MET155F, MET155H, MET253F, MET253H, MET43F, MET43H, MET62F, MET62H, PHE164F, PHE164H, PHE228F, PHE228H, PHE243F, PHE243H, PHE72F, PHE72H, PRO176F, PRO176H, PRO246F, PRO246H, PRO51F, PRO51H, PRO68F, PRO68H, SER161F, SER161H, SER169F, SER169H, SER177F, SER177H, SER241F, SER241H, SER249F, SER249H, SER27F, SER27H, SER67F, SER67H, THR226F, THR226H, THR239F, THR239H, THR28F, THR28H, TYR244F, TYR244H, VAL158F, VAL158H, VAL174F, VAL174H, VAL179F, VAL179H, VAL234F, VAL234H, VAL251F, VAL251H, VAL50F, VAL50H
• G-H: ALA181G, ALA181H, ALA252G, ALA252H, ALA256G, ALA256H, ARG165G, ARG165H, ASN300G, ASN300H, ASP178G, ASP178H, ASP207G, ASP207H, ASP260G, ASP260H, ASP295G, ASP295H, GLN211G, GLN211H, GLN255G, GLN255H, GLN274G, GLU210G, GLU210H, GLU294G, GLU294H, GLY173G, GLY173H, GLY201G, GLY201H, GLY202G, GLY202H, ILE182G, ILE182H, ILE200G, ILE200H, ILE203G, ILE203H, ILE288G, ILE288H, ILE298G, ILE298H, LEU172G, LEU172H, LEU194G, LEU194H, LEU204G, LEU204H, LEU205G, LEU205H, LEU265G, LEU265H, LEU301G, LEU301H, LYS175G, LYS175H, LYS213G, LYS213H, LYS259G, LYS259H, LYS262G, LYS262H, MET253G, PHE208G, PHE208H, PRO176G, PRO176H, PRO285G, PRO285H, SER161G, SER161H, SER169G, SER169H, SER177G, SER177H, SER180G, SER180H, SER196G, SER196H, SER197G, SER197H, SER206G, SER206H, SER261G, SER261H, SER263G, SER263H, THR195G, THR195H, THR199G, THR199H, TYR275G, TYR275H, VAL174G, VAL174H, VAL179G, VAL179H, VAL183G, VAL183H, VAL184G, VAL184H, VAL198G, VAL198H, VAL209H, VAL264G, VAL264H, VAL266G, VAL266H, VAL284G, VAL284H, VAL286G, VAL286H, VAL287G, VAL287H, VAL296G, VAL296H, VAL297G, VAL297H, VAL299G, VAL299H
• I-J: ALA181I, ALA181J, ALA252I, ALA252J, ALA256I, ALA256J, ARG165I, ARG165J, ASN300I, ASN300J, ASP178I, ASP178J, ASP207I, ASP207J, ASP260I, ASP260J, ASP295I, ASP295J, GLN211I, GLN211J, GLN255I, GLN255J, GLN274I, GLU210I, GLU210J, GLU294I, GLU294J, GLY173I, GLY173J, GLY201I, GLY201J, GLY202I, GLY202J, ILE182I, ILE182J, ILE200I, ILE200J, ILE203I, ILE203J, ILE288I, ILE288J, ILE298I, ILE298J, LEU172I, LEU172J, LEU194I, LEU194J, LEU204I, LEU204J, LEU205I, LEU205J, LEU265I, LEU265J, LEU301I, LEU301J, LYS175I, LYS175J, LYS213I, LYS213J, LYS259I, LYS259J, LYS262I, LYS262J, PHE208I, PHE208J, PRO176I, PRO176J, PRO285I, PRO285J, SER161I, SER161J, SER169I, SER169J, SER177I, SER177J, SER180I, SER180J, SER196I, SER196J, SER197I, SER197J, SER206I, SER206J, SER261I, SER261J, SER263I, SER263J, THR195I, THR195J, THR199I, THR199J, TYR275I, TYR275J, VAL174I, VAL174J, VAL179I, VAL179J, VAL183I, VAL183J, VAL184I, VAL184J, VAL198I, VAL198J, VAL209I, VAL209J, VAL264I, VAL264J, VAL266I, VAL266J, VAL284I, VAL284J, VAL286I, VAL286J, VAL287I, VAL287J, VAL296I, VAL296J, VAL297I, VAL297J, VAL299I, VAL299J
• I-K: ALA256I, ALA256K, ALA69I, ALA69K, ARG14I, ARG14K, ASN291I, ASN291K, ASP260I, ASP260K, ASP37I, ASP37K, ASP40I, ASP40K, GLN255I, GLN255K, GLY289K, GLY39I, GLY39K, GLY66I, GLY66K, LEU258I, LEU258K, LEU33I, LEU33K, LEU38I, LEU38K, LYS15I, LYS15K, LYS259I, LYS259K, LYS262I, LYS262K, LYS290I, LYS290K, LYS36I, LYS36K, LYS70I, LYS70K, MET13I, MET13K, PRO68I, PRO68K, SER261I, SER261K, SER263I, SER263K, SER67I, SER67K, TYR257I, TYR257K
• I-L: ALA162I, ALA162L, ALA22I, ALA22L, ALA242I, ALA242L, ALA245I, ALA245L, ALA247I, ALA247L, ALA248I, ALA248L, ALA250I, ALA250L, ALA252I, ALA252L, ALA30I, ALA30L, ALA55I, ALA55L, ALA63I, ALA63L, ALA69I, ALA69L, ARG14I, ARG14L, ARG163I, ARG163L, ARG165I, ARG165L, ARG170I, ARG170L, ASN167I, ASN167L, ASN59I, ASN59L, ASN75I, ASN75L, ASP160I, ASP160L, ASP178I, ASP178L, ASP37I, ASP37L, ASP57I, ASP57L, CYS166I, CYS166L, CYS61I, CYS61L, GLN24I, GLN24L, GLN35I, GLN35L, GLN52I, GLN52L, GLU232I, GLU232L, GLU235I, GLU235L, GLU48I, GLU48L, GLY157I, GLY157L, GLY173I, GLY173L, GLY229I, GLY229L, GLY230I, GLY230L, GLY231I, GLY231L, GLY23I, GLY23L, GLY240I, GLY240L, GLY26I, GLY26L, GLY49I, GLY49L, GLY53I, GLY53L, GLY66I, GLY66L, GLY73I, GLY73L, HIS60I, HIS60L, ILE233I, ILE233L, ILE25I, ILE25L, ILE29I, ILE29L, ILE47I, ILE47L, ILE65I, ILE65L, ILE71I, ILE71L, LEU159I, LEU159L, LEU236I, LEU236L, LEU237I, LEU237L, LEU265I, LEU265L, LEU31I, LEU31L, LEU32I, LEU32L, LEU56I, LEU56L, LEU58I, LEU58L, LEU64I, LEU64L, LYS175I, LYS175L, LYS225I, LYS225L, LYS238I, LYS238L, LYS36I, LYS36L, LYS54I, LYS54L, LYS70I, LYS70L, MET155I, MET155L, MET253I, MET253L, MET43I, MET43L, MET62I, MET62L, PHE164I, PHE164L, PHE228I, PHE228L, PHE243I, PHE243L, PHE72I, PHE72L, PRO176I, PRO176L, PRO246I, PRO246L, PRO51I, PRO51L, PRO68I, PRO68L, SER161I, SER161L, SER169I, SER169L, SER177I, SER177L, SER241I, SER241L, SER249I, SER249L, SER27I, SER27L, SER67I, SER67L, THR226I, THR226L, THR239I, THR239L, THR28I, THR28L, TYR244I, TYR244L, VAL158I, VAL158L, VAL174I, VAL174L, VAL179I, VAL179L, VAL234I, VAL234L, VAL251I, VAL251L, VAL50I, VAL50L
• J-K: ALA162J, ALA162K, ALA22J, ALA22K, ALA242J, ALA242K, ALA245J, ALA245K, ALA247J, ALA247K, ALA248J, ALA248K, ALA250J, ALA250K, ALA252J, ALA252K, ALA30J, ALA30K, ALA55J, ALA55K, ALA63J, ALA63K, ALA69J, ALA69K, ARG14J, ARG14K, ARG163J, ARG163K, ARG165J, ARG165K, ARG170J, ARG170K, ASN167J, ASN167K, ASN59J, ASN59K, ASN75J, ASN75K, ASP160J, ASP160K, ASP178J, ASP178K, ASP37J, ASP57J, ASP57K, CYS166J, CYS166K, CYS61J, CYS61K, GLN24J, GLN24K, GLN255J, GLN35J, GLN35K, GLN52J, GLN52K, GLU232J, GLU232K, GLU235J, GLU235K, GLU48J, GLU48K, GLY157J, GLY157K, GLY173J, GLY173K, GLY229J, GLY229K, GLY230J, GLY230K, GLY231J, GLY231K, GLY23J, GLY23K, GLY240J, GLY26J, GLY26K, GLY49J, GLY49K, GLY53J, GLY53K, GLY66J, GLY66K, GLY73J, GLY73K, HIS60J, HIS60K, ILE233J, ILE233K, ILE25J, ILE25K, ILE29J, ILE29K, ILE47J, ILE47K, ILE65J, ILE65K, ILE71J, ILE71K, LEU159J, LEU159K, LEU236J, LEU236K, LEU237J, LEU237K, LEU265J, LEU265K, LEU31J, LEU31K, LEU32J, LEU32K, LEU56J, LEU56K, LEU58J, LEU58K, LEU64J, LEU64K, LYS175J, LYS175K, LYS225J, LYS225K, LYS238J, LYS238K, LYS36J, LYS36K, LYS54J, LYS54K, LYS70J, LYS70K, MET155K, MET253J, MET253K, MET43J, MET43K, MET62J, MET62K, PHE164J, PHE164K, PHE228J, PHE228K, PHE243J, PHE243K, PHE72J, PHE72K, PRO176J, PRO176K, PRO246J, PRO246K, PRO51J, PRO51K, PRO68J, PRO68K, SER161J, SER161K, SER169J, SER169K, SER177J, SER177K, SER241J, SER241K, SER249J, SER249K, SER27J, SER27K, SER67J, SER67K, THR226J, THR226K, THR239J, THR239K, THR28J, THR28K, TYR244J, TYR244K, VAL158J, VAL158K, VAL174J, VAL174K, VAL179J, VAL179K, VAL234J, VAL234K, VAL251J, VAL251K, VAL50J, VAL50K
• J-L: ALA256J, ALA256L, ALA69J, ALA69L, ARG14J, ARG14L, ASN291J, ASN291L, ASP260J, ASP260L, ASP37J, ASP37L, ASP40J, ASP40L, GLN255J, GLN255L, GLY289J, GLY39J, GLY39L, GLY66J, GLY66L, LEU258J, LEU258L, LEU33J, LEU33L, LEU38J, LEU38L, LYS15J, LYS15L, LYS259J, LYS259L, LYS262J, LYS262L, LYS290J, LYS290L, LYS36J, LYS36L, LYS70J, LYS70L, MET13J, MET13L, PRO68J, PRO68L, SER261J, SER261L, SER263J, SER263L, SER67J, SER67L, TYR257J, TYR257L
• K-L: ALA181K, ALA181L, ALA252K, ALA252L, ALA256K, ALA256L, ARG165K, ARG165L, ASN300K, ASN300L, ASP178K, ASP178L, ASP207K, ASP207L, ASP260K, ASP260L, ASP295K, ASP295L, GLN211K, GLN211L, GLN255K, GLN255L, GLN274K, GLN274L, GLU210K, GLU210L, GLU294K, GLU294L, GLY173K, GLY173L, GLY201K, GLY201L, GLY202K, GLY202L, GLY212K, ILE182K, ILE182L, ILE200K, ILE200L, ILE203K, ILE203L, ILE288K, ILE288L, ILE298K, ILE298L, LEU172K, LEU172L, LEU194K, LEU194L, LEU204K, LEU204L, LEU205K, LEU205L, LEU265K, LEU265L, LEU301K, LEU301L, LYS175K, LYS175L, LYS213K, LYS213L, LYS259K, LYS259L, LYS262K, LYS262L, PHE208K, PHE208L, PRO176K, PRO176L, PRO285K, PRO285L, SER161K, SER161L, SER169K, SER169L, SER177K, SER177L, SER180K, SER180L, SER196K, SER196L, SER197K, SER197L, SER206K, SER206L, SER261K, SER261L, SER263K, SER263L, THR195K, THR195L, THR199K, THR199L, TYR275K, TYR275L, VAL174K, VAL174L, VAL179K, VAL179L, VAL183K, VAL183L, VAL184K, VAL184L, VAL198K, VAL198L, VAL209K, VAL209L, VAL264K, VAL264L, VAL266K, VAL266L, VAL284K, VAL286K, VAL286L, VAL287K, VAL287L, VAL296K, VAL296L, VAL297K, VAL297L, VAL299K, VAL299L