2HGU

70s t.th. ribosome functional complex with mrna and e- and p-site trnas at 4.5a. this entry 2hgu contains 50s ribosomal subunit. the 30s ribosomal subunit can be found in pdb entry 2hgr.

• Total interactions analyzed: 496
• Total true interactions: 28
• Strongest Interaction:
  • Chains: O-U
  • Int. Res.: 14
  • Norm. En. per Res.: -2.0988
• Hub Node: E(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
E-M	0.0	0.0	-21.5103	-21.5103	14	21	1	1423	0	0	1
E-N	-8.7336	-0.8301	-24.1894	-33.7531	17	2	0	741	0	11	7
E-Q	0.0	0.6544	-1.2104	-0.5559	13	3	0	560	0	0	12
E-S	-7.2479	10.876	-87.0805	-83.4524	65	31	7	6683	0	22	18
F-O	-31.0982	3.5787	-46.0917	-73.6111	37	31	0	3331	1	8	13
F-T	0.0	0.0	-0.4327	-0.4327	9	0	0	149	0	0	1
F-6	0.0	0.0	-0.0409	-0.0409	5	0	0	30	0	0	0
H-8	-5.2895	-9.6038	-7.0057	-21.899	13	0	0	381	0	2	5
K-3	0.0	4.6342	-7.0744	-2.4402	26	0	0	787	0	3	9
L-P	0.0	0.0	-0.0024	-0.0024	2	0	0	4	0	0	3
L-Y	0.0	6.7744	-12.9562	-6.1818	18	5	0	900	0	6	6
M-T	0.0	0.6925	-77.425	-76.7325	48	41	1	5212	1	7	26
M-U	0.0	0.0	-0.5683	-0.5683	10	0	0	216	0	2	5
N-S	-45.19	-12.7354	-108.6	-166.5253	87	144	8	11510	0	33	47
O-U	-31.1332	13.403	-11.6533	-29.3835	14	5	0	687	0	0	7
O-7	-18.9346	-10.3649	-56.8502	-86.1496	62	82	1	7579	1	20	50
P-Y	-15.7533	-20.3441	-133.354	-169.4514	96	18	2	6536	0	51	43
P-Z	-8.3478	13.1128	-8.3732	-3.6083	23	25	0	1890	1	3	11
P-8	0.0	0.0	-0.1908	-0.1908	4	0	0	74	0	2	2
Q-V	0.0	0.0	-14.0026	-14.0026	19	1	0	801	0	5	7
Q-4	-2.69	-2.3479	-38.2726	-43.3105	43	21	2	3069	2	7	14
R-Z	0.0	-10.8929	-3.3358	-14.2287	12	0	0	265	1	6	7
T-U	-27.9527	13.9283	-18.8732	-32.8975	91	143	6	9288	3	25	51
T-4	0.0	0.0	-9.0088	-9.0088	11	6	0	616	0	0	8
V-4	0.0	23.2431	-86.6274	-63.3843	47	20	3	4192	0	9	16
W-1	-11.1147	-16.445	-23.0919	-50.6516	41	36	0	3766	0	8	10
W-6	0.0	0.0	-7.3279	-7.3279	4	2	0	247	0	1	5
5-7	0.0	0.8453	-19.4392	-18.5939	21	25	0	1504	0	6	3

Interface residues

• E-M: ARG149E, ARG74M, GLY153E, GLY77M, GLY80M, GLY81M, LYS152E, PRO147E, PRO79M, SER76M, TYR151E, TYR75M, TYR78M, VAL150E
• E-N: ALA20E, ARG13E, ARG19E, ARG71N, ASP17E, ASP18E, ASP73N, GLY74N, ILE14E, LYS31N, LYS70N, PHE122E, PHE15E, PRO72N, THR12E, VAL21E, VAL69N
• E-Q: ALA114E, ALA162E, ARG111E, ARG2Q, GLY110E, GLY112E, GLY161E, HIS3Q, LEU4Q, LYS109E, LYS118E, LYS5Q, PHE113E
• E-S: ALA20E, ALA5S, ARG13E, ARG13S, ARG16E, ARG19E, ARG3S, ARG41S, ASN180E, ASN192E, ASN2S, ASN58S, ASP174E, ASP17E, ASP18E, GLN84S, GLU11S, GLU178E, GLU179E, GLY10E, GLY193E, GLY194E, GLY4S, GLY6E, HIS79S, ILE14E, ILE176E, ILE26E, ILE7S, ILE83S, LEU181E, LEU182E, LEU183E, LEU6S, LEU82S, LEU9S, LYS35S, LYS85S, LYS8E, LYS8S, MET11E, MET1S, PHE15E, PHE51E, PHE61S, PRO177E, PRO22E, PRO81S, SER12S, SER80S, THR12E, THR24E, THR59S, THR60S, THR62S, TYR14S, VAL10S, VAL15S, VAL173E, VAL175E, VAL21E, VAL23E, VAL25E, VAL7E, VAL9E
• F-O: ALA113F, ALA12O, ARG117F, ARG15O, ARG188F, ARG38F, ARG41O, ARG7O, ASN13O, ASN29F, ASN9O, ASP116F, GLN38O, GLU190F, GLU35F, GLY11O, HIS31F, ILE186F, LEU101F, LEU32F, LEU33F, LEU6O, LYS14O, PHE90F, PRO10O, PRO30F, PRO81F, PRO8O, THR189F, TRP34F, TYR184F, VAL105F, VAL183F, VAL187F, VAL36F, VAL37F, VAL89F
• F-T: ALA49F, ALA4T, ARG3T, LYS52F, PRO2T, PRO92F, SER50F, THR48F, VAL88F
• F-6: ALA58F, GLY386, LYS376, TRP406, TYR59F
• H-8: ALA156H, ARG170H, ARG188, ARG59H, ASN298, CYS118, CYS278, GLU288, HIS328, LYS172H, LYS318, PRO308, SER63H
• K-3: ALA26K, ARG27K, ARG583, ARG623, ASN28K, ASN43K, ASP653, GLN463, GLN473, GLY24K, GLY453, GLY703, LEU31K, LEU38K, LYS693, MET1K, PHE423, PHE593, PRO23K, PRO32K, SER42K, SER663, THR40K, THR443, TYR633, VAL37K
• L-P: ARG59P, ARG93L
• L-Y: ALA109Y, ALA113Y, ARG112Y, ARG132L, ARG93L, GLU137L, GLU94L, GLY110Y, GLY114Y, GLY115Y, GLY92L, LYS95L, PRO108Y, PRO177Y, PRO91L, VAL111Y, VAL116Y, VAL180Y
• M-T: ALA47M, ALA67T, ALA68T, ALA96T, ALA99T, ARG101T, ARG35M, ARG39M, ARG59T, ARG64T, ARG70T, ARG92T, ASN66T, ASN75T, ASN94T, ASP41M, ASP97T, CYS69T, GLN71T, GLU102T, GLY36M, HIS38M, HIS72T, ILE62T, ILE65T, LEU60T, LEU98T, LYS2M, LYS37M, LYS7M, LYS93T, MET48M, PHE106T, PHE57T, PRO103T, PRO40M, PRO44M, PRO6M, THR32M, THR3M, THR43M, TRP42M, TRP61T, TYR4M, VAL100T, VAL105T, VAL5M, VAL63T
• M-U: ARG13U, ARG21U, GLU43U, LYS19U, LYS2M, LYS6U, PHE2U, TYR12U, TYR4M, VAL14U
• N-S: ALA103N, ALA118N, ALA76N, ARG103S, ARG104N, ARG107N, ARG108S, ARG17N, ARG39S, ARG53S, ARG64N, ARG64S, ARG71N, ARG74S, ARG78N, ARG97N, ASN104S, ASN38S, ASN82N, ASP107S, ASP73N, ASP80N, ASP81N, GLN84S, GLU105N, GLU108N, GLU109S, GLU120N, GLU36S, GLU46S, GLU68N, GLU73S, GLY100N, GLY110N, GLY37S, GLY69S, GLY71S, GLY74N, HIS79S, ILE114N, ILE42S, ILE48S, ILE50S, ILE75S, ILE77N, ILE83S, LEU105S, LEU106N, LEU122N, LEU78S, LEU82S, LYS109N, LYS35S, LYS65S, LYS66N, LYS67N, LYS70N, LYS85S, MET112N, PHE101S, PHE111N, PHE76S, PHE79N, PHE99N, PRO101N, PRO119N, PRO72N, PRO77S, SER106S, SER116N, SER67S, SER75N, THR62S, THR65N, TYR68S, VAL102N, VAL115N, VAL121N, VAL34S, VAL62N, VAL63N, VAL63S, VAL66S, VAL69N, VAL70S, VAL72S, VAL98N
• O-U: ARG82U, ARG83U, GLN80U, GLY26O, GLY28O, HIS27O, LYS29O, LYS76U, LYS78U, LYS84U, LYS85U, SER25O, TYR81U, VAL79U
• O-7: ALA107, ALA247, ALA517, ALA557, ARG137, ARG307, ARG467, ARG49O, ARG50O, ARG55O, ARG577, ARG61O, ASP47O, GLU52O, GLU547, GLU567, GLY287, GLY43O, GLY44O, GLY457, GLY53O, GLY54O, GLY97, HIS317, HIS77, ILE587, LEU106O, LEU327, LEU45O, LEU59O, LEU607, LEU627, LEU62O, LYS117, LYS127, LYS157, LYS267, LYS297, LYS37, LYS447, LYS46O, LYS477, LYS527, LYS57, LYS597, LYS87, MET257, MET47, MET60O, PHE51O, PRO48O, PRO537, PRO637, SER56O, THR277, THR57O, THR58O, THR67, TYR647, VAL147, VAL237, VAL497
• P-Y: ALA107P, ALA136P, ALA140P, ALA164Y, ALA173Y, ALA20P, ALA36P, ALA51Y, ARG101P, ARG122Y, ARG133P, ARG134P, ARG49Y, ARG56P, ARG59P, ARG60P, ARG72Y, ARG79Y, ARG80Y, ARG81Y, ARG82Y, ASP123Y, ASP135P, ASP138P, ASP179Y, ASP25P, ASP31P, ASP77Y, GLN118Y, GLN141P, GLN50Y, GLN73Y, GLU119Y, GLU139P, GLU169Y, GLU178Y, GLU38P, GLU97Y, GLY100P, GLY108P, GLY114Y, GLY115Y, GLY23P, GLY24P, GLY30P, GLY61P, GLY62P, HIS121Y, HIS54Y, HIS55Y, ILE120Y, ILE124Y, ILE131P, ILE53Y, ILE64P, LEU102Y, LEU117Y, LEU125Y, LEU37P, LEU76Y, LYS130P, LYS22P, LYS63P, LYS78Y, LYS98P, MET98Y, PHE29P, PHE48Y, PHE58P, PHE65P, PRO101Y, PRO176Y, PRO177Y, PRO39P, PRO83Y, PRO99P, SER166Y, SER52Y, THR21P, TYR137P, TYR26P, TYR32P, TYR99Y, VAL100Y, VAL106P, VAL109P, VAL111Y, VAL116Y, VAL126Y, VAL132P, VAL165Y, VAL175Y, VAL35P, VAL55P, VAL71Y, VAL74Y
• P-Z: ARG11Z, ARG14P, ARG82P, ASN12Z, ASN89P, GLU80P, GLY6Z, GLY84P, GLY86P, GLY88P, GLY8Z, HIS3Z, LEU79P, LEU7Z, LYS4Z, LYS5Z, LYS85P, LYS87P, MET83P, PRO78P, SER9Z, THR10Z, VAL81P
• P-8: ARG119P, HIS123P, LYS88, SER68
• Q-V: ALA101Q, ALA109Q, ALA44V, ARG103Q, ARG104Q, ARG105Q, ARG37V, ARG42V, ASN40V, ASP107Q, GLU102Q, GLY106Q, GLY108Q, LEU100Q, LYS41V, PRO110Q, THR39V, TYR38V, TYR45V
• Q-4: ALA101Q, ALA112Q, ALA534, ARG103Q, ARG33Q, ARG554, ARG96Q, CYS464, GLU102Q, GLU115Q, GLU118Q, GLU484, GLY32Q, GLY504, GLY544, HIS434, ILE34Q, LEU100Q, LEU111Q, LEU113Q, LEU116Q, LEU584, LEU98Q, LYS404, LYS42Q, LYS564, LYS99Q, MET394, PRO110Q, PRO284, PRO414, PRO424, PRO474, THR35Q, THR444, TYR514, TYR524, VAL114Q, VAL117Q, VAL38Q, VAL454, VAL574, VAL97Q
• R-Z: ARG15R, ARG23R, ARG72Z, ARG74Z, ASP42R, GLU43R, LEU75Z, LYS19R, LYS44R, LYS49Z, PRO47Z, THR21R
• T-U: ALA3U, ALA41T, ALA42T, ALA46T, ALA48T, ALA55U, ALA77U, ALA86T, ARG101T, ARG112T, ARG13U, ARG21U, ARG36T, ARG50T, ARG53T, ARG83U, ARG92T, ASN44T, ASN94T, ASP91T, ASP97T, GLN104T, GLN11U, GLN80U, GLN89U, GLU102T, GLU108T, GLU111T, GLU37T, GLU43U, GLU53U, GLU89T, GLY41U, GLY42U, GLY43T, GLY48U, GLY54U, GLY86U, GLY87T, GLY9U, HIS49T, HIS87U, ILE17T, ILE4U, ILE88T, LEU109T, LEU20T, LEU38U, LEU39T, LEU39U, LEU40U, LEU83T, LEU95T, LEU98T, LYS10U, LYS44U, LYS51T, LYS6U, LYS74U, LYS76U, LYS78U, LYS84U, LYS85T, LYS85U, LYS93T, PHE2U, PHE40T, PHE75U, PRO103T, PRO50U, SER56U, SER73U, THR38T, THR45U, THR49U, TRP61T, TYR12U, TYR45T, TYR47T, TYR81U, TYR91U, VAL105T, VAL14U, VAL46U, VAL47U, VAL51U, VAL52U, VAL57U, VAL5U, VAL79U, VAL90T
• T-4: ALA144, ARG154, ARG164, GLY26T, LEU27T, LYS104, LYS134, LYS30T, SER124, THR114, TRP25T
• V-4: ALA244, ALA384, ARG15V, ARG164, ARG18V, ARG194, ARG204, ARG25V, ARG33V, ARG37V, ASN34V, ASN40V, ASP22V, CYS464, GLU30V, GLU31V, GLU484, HIS234, ILE24V, ILE35V, LEU19V, LEU23V, LEU254, LEU304, LEU36V, LYS16V, LYS27V, LYS374, LYS404, LYS41V, MET394, PRO14V, PRO274, PRO284, PRO414, PRO474, THR264, THR294, THR39V, THR444, TYR38V, TYR75V, VAL17V, VAL20V, VAL21V, VAL314, VAL454
• W-1: ALA10W, ALA341, ALA42W, ALA46W, ALA4W, ARG211, ARG251, ARG311, ASP6W, GLN331, GLU221, GLU261, GLU291, HIS31W, ILE361, ILE521, ILE8W, ILE96W, LEU13W, LEU271, LEU561, LEU591, LEU92W, LEU95W, LEU9W, LYS241, LYS48W, LYS491, MET281, PHE28W, PHE321, PHE47W, PRO11W, SER351, THR3W, THR45W, TRP29W, TYR5W, VAL201, VAL43W, VAL7W
• W-6: ARG496, ARG60W, LYS486, LYS62W
• 5-7: ALA225, ARG427, ASN265, ASN337, CYS135, GLN357, GLU125, GLU245, GLU407, GLY387, ILE417, LEU105, LEU115, LEU95, LYS255, LYS367, LYS397, SER377, THR235, TRP347, TYR395