2HD0

structure of the catalytic domain of hepatitis c virus ns2

• Total interactions analyzed: 66
• Total true interactions: 31
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 157
  • Norm. En. per Res.: -5.3763
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-236.3379	24.32	-632.875	-844.8929	160	45	8	25015	0	28	24
A-C	-13.6675	1.2017	-49.4232	-61.8889	38	2	3	2524	0	1	8
A-E	-11.1421	1.0953	-48.4461	-58.493	38	2	3	2499	0	1	6
A-F	0.0	9.5967	-4.0245	5.5721	7	3	0	387	0	2	4
A-J	-10.3041	0.0	-24.8715	-35.1756	25	3	0	1069	4	6	4
B-C	0.0	9.6643	-9.5344	0.1299	6	1	0	308	0	2	4
B-D	0.0	0.9062	-35.858	-34.9518	29	0	3	2006	0	1	7
B-F	-9.3958	1.0619	-38.0001	-46.334	32	1	3	2175	0	1	7
B-I	0.0	0.0	-9.0308	-9.0308	14	0	0	399	0	4	4
B-J	0.0	0.0	-31.2582	-31.2582	29	0	1	1624	0	6	9
C-D	-193.0619	22.7822	-659.375	-829.6547	157	44	8	25001	0	28	24
C-E	0.0	0.917	-46.2677	-45.3507	33	0	3	2415	0	1	8
D-E	0.0	0.0	-0.918	-0.918	6	0	0	114	0	2	4
D-F	0.0	0.0	-38.8622	-38.8622	30	0	3	1976	0	1	7
E-F	-219.661	30.121	-649.964	-839.5039	158	43	10	24738	0	28	23
E-H	0.0	0.0	-0.0137	-0.0137	3	0	0	9	0	3	0
F-H	0.0	0.0	-7.0938	-7.0938	12	1	0	230	0	4	3
F-I	0.0	0.0	-0.2044	-0.2044	7	0	1	57	0	1	0
F-J	0.0	0.0	-27.1574	-27.1574	19	0	0	1135	0	4	3
G-H	-205.1324	22.0684	-674.736	-857.8	160	40	10	25356	0	28	24
G-I	-7.4006	0.9312	-53.2048	-59.6742	32	1	3	2634	0	1	8
G-K	0.0	0.0	-45.3988	-45.3988	32	0	3	2154	0	1	8
G-L	0.0	-13.3068	-3.5098	-16.8166	6	0	0	219	0	2	4
H-I	0.0	-9.2316	-1.3163	-10.5479	7	0	0	168	0	2	4
H-J	-12.5151	1.2328	-44.9508	-56.2331	37	1	3	2531	0	1	7
H-L	0.0	1.2893	-41.6454	-40.3561	32	0	3	2254	0	1	6
I-J	-196.692	26.2387	-636.444	-806.8973	159	42	8	24863	0	28	25
I-K	-11.6613	1.3825	-40.5016	-50.7804	31	1	3	2164	0	1	7
J-K	0.0	-4.2758	-0.4279	-4.7036	6	0	0	101	0	2	4
J-L	0.0	1.8843	-52.2332	-50.3489	34	0	3	2500	0	1	8
K-L	-223.3261	27.0099	-647.767	-844.0832	157	50	8	24865	0	27	23

Interface residues

• A-B: ALA134A, ALA134B, ALA159A, ALA159B, ALA161A, ALA161B, ALA179A, ALA179B, ALA182A, ALA182B, ALA183A, ALA183B, ALA195A, ALA195B, ALA206A, ALA206B, ALA95A, ALA95B, ARG105A, ARG105B, ARG156A, ARG156B, ARG169A, ARG169B, ARG196A, ARG196B, ARG197A, ARG197B, ARG215A, ARG215B, ASN142A, ASN142B, ASN189A, ASN189B, ASP180A, ASP180B, ASP186A, ASP186B, ASP207A, ASP207B, CYS184A, CYS184B, GLN199A, GLN199B, GLN94A, GLN94B, GLU163A, GLU163B, GLU171A, GLU171B, GLU200A, GLU200B, GLY133A, GLY133B, GLY137A, GLY137B, GLY178A, GLY178B, GLY185A, GLY185B, GLY190A, GLY190B, GLY198A, GLY198B, GLY204A, GLY204B, GLY208A, GLY208B, HIS143A, HIS143B, HIS3A, HIS3B, ILE175A, ILE175B, ILE187A, ILE187B, ILE188A, ILE188B, ILE201A, ILE201B, LEU135A, LEU135B, LEU144A, LEU144B, LEU174A, LEU174B, LEU191A, LEU191B, LEU202A, LEU202B, LEU203A, LEU203B, LEU216A, LEU216B, LEU217A, LEU217B, LEU97A, LEU97B, LYS173A, LYS173B, LYS99A, LYS99B, MET170A, MET170B, MET209A, MET209B, MET4A, MET4B, PHE103A, PHE103B, PRO164A, PRO164B, PRO192A, PRO192B, PRO205A, PRO205B, SER168A, SER168B, SER194A, SER194B, SER2A, SER2B, SER96A, SER96B, THR136A, THR136B, THR138A, THR138B, THR172A, THR172B, THR176A, THR176B, THR181A, THR181B, TRP177A, TRP177B, TRP214A, TRP214B, TYR102A, TYR102B, TYR139A, TYR139B, TYR141A, TYR141B, VAL106A, VAL106B, VAL140A, VAL140B, VAL160A, VAL160B, VAL162A, VAL162B, VAL165A, VAL165B, VAL166A, VAL166B, VAL193A, VAL193B, VAL210A, VAL210B
• A-C: ALA116C, ALA120C, ALA128C, ALA159C, ARG105A, ARG111A, ARG169C, GLN126C, GLY108A, GLY121C, GLY122C, HIS123C, ILE112A, ILE119C, ILE129C, ILE130C, LEU132A, LEU132C, LEU135A, LEU135C, LEU158C, LEU97A, LEU98A, LYS131C, LYS99A, MET127C, PHE103A, PHE167C, PRO101A, SER168C, SER96A, THR136A, TYR124C, VAL100A, VAL104A, VAL125C, VAL160C, VAL166C
• A-E: ALA116A, ALA120A, ALA128A, ALA159A, ARG105E, ARG111E, ARG169A, GLN107E, GLN126A, GLY108E, GLY121A, GLY122A, HIS123A, ILE112E, ILE119A, ILE129A, ILE130A, LEU132A, LEU132E, LEU135A, LEU135E, LEU158A, LEU97E, LEU98E, LYS131A, LYS99E, MET127A, PHE167A, PRO101E, SER168A, SER96E, THR136E, TYR124A, VAL100E, VAL104E, VAL125A, VAL160A, VAL166A
• A-F: ARG169A, ARG169F, GLU171A, GLU171F, MET170F, SER168A, SER168F
• A-J: ALA151J, ALA182A, ALA183A, ARG117J, ARG148J, ASN153J, ASP149J, ASP180A, ASP186A, CYS184A, GLY178A, GLY185A, ILE175A, ILE187A, ILE188A, LEU147J, LEU174A, LEU217A, LYS118J, PRO146J, THR176A, THR181A, TRP150J, TRP177A, VAL193A
• B-C: ARG169B, ARG169C, GLU171B, GLU171C, LYS173C, SER168B
• B-D: ALA120B, ALA128B, ARG105D, ARG111D, GLN126B, GLY108D, GLY121B, HIS123B, ILE112D, ILE129B, ILE130B, LEU132B, LEU132D, LEU135B, LEU158B, LEU97D, LEU98D, LYS131B, LYS99D, MET127B, PHE167B, PRO101D, SER168B, SER96D, THR136D, TYR124B, VAL100D, VAL104D, VAL125B
• B-F: ALA120F, ALA128F, ALA159F, ARG105B, ARG169F, GLN107B, GLY108B, GLY121F, HIS123F, ILE112B, ILE129F, LEU132B, LEU132F, LEU135B, LEU135F, LEU158F, LEU97B, LEU98B, LYS131F, LYS99B, MET127F, PHE167F, PRO101B, SER168F, SER96B, THR136B, TYR124F, VAL100B, VAL104B, VAL125F, VAL160F, VAL166F
• B-I: ALA182I, ALA183I, ARG215I, ASP149B, CYS184I, GLN107B, HIS143B, LEU144B, LEU216I, LEU217I, PHE103B, THR145B, VAL104B, VAL210I
• B-J: ALA95B, ARG105B, ARG117J, ARG148J, ARG197B, ASN142J, ASN153J, ASP149J, GLN107B, GLN107J, GLN199B, GLN94B, GLU200B, GLY198B, HIS143J, HIS3B, LEU144J, LYS118J, LYS99B, MET4B, PHE103B, PHE103J, PRO101B, PRO146J, SER2B, THR145J, TYR102B, VAL100B, VAL104B
• C-D: ALA134C, ALA134D, ALA159C, ALA161C, ALA161D, ALA179C, ALA179D, ALA182C, ALA182D, ALA183C, ALA183D, ALA195C, ALA195D, ALA206C, ALA206D, ALA95C, ALA95D, ARG105C, ARG105D, ARG156C, ARG169C, ARG169D, ARG196C, ARG196D, ARG197C, ARG197D, ARG215C, ARG215D, ASN142C, ASN142D, ASN189C, ASN189D, ASP180C, ASP180D, ASP186C, ASP186D, ASP207C, ASP207D, CYS184C, CYS184D, GLN199C, GLN199D, GLN94C, GLN94D, GLU163C, GLU163D, GLU171C, GLU171D, GLU200C, GLU200D, GLY133C, GLY133D, GLY137C, GLY137D, GLY178C, GLY178D, GLY185C, GLY185D, GLY190C, GLY190D, GLY198C, GLY198D, GLY204C, GLY204D, GLY208C, GLY208D, HIS143C, HIS143D, HIS3C, HIS3D, ILE175C, ILE175D, ILE187C, ILE187D, ILE188C, ILE188D, ILE201C, ILE201D, LEU144C, LEU144D, LEU174C, LEU174D, LEU191C, LEU191D, LEU202C, LEU202D, LEU203C, LEU203D, LEU216C, LEU216D, LEU217C, LEU217D, LEU97C, LEU97D, LYS173C, LYS173D, LYS212D, LYS99C, LYS99D, MET170C, MET170D, MET209C, MET209D, MET4C, MET4D, PHE103C, PHE103D, PRO164C, PRO164D, PRO192C, PRO192D, PRO205C, PRO205D, SER168C, SER168D, SER194C, SER194D, SER2C, SER2D, SER96C, SER96D, THR136C, THR136D, THR138C, THR138D, THR172C, THR172D, THR176C, THR176D, THR181C, THR181D, TRP177C, TRP177D, TRP214C, TRP214D, TYR102C, TYR102D, TYR139C, TYR139D, TYR141C, TYR141D, VAL106C, VAL106D, VAL140C, VAL140D, VAL160C, VAL160D, VAL162C, VAL162D, VAL165C, VAL165D, VAL166C, VAL166D, VAL193C, VAL193D, VAL210C, VAL210D
• C-E: ALA116E, ALA120E, ALA128E, ALA159E, ARG105C, ARG111C, ARG169E, GLY108C, GLY121E, GLY122E, HIS123E, ILE112C, ILE119E, ILE129E, LEU132C, LEU132E, LEU135E, LEU158E, LEU97C, LEU98C, LYS131E, LYS99C, MET127E, PHE167E, PRO101C, SER168E, SER96C, THR136C, TYR124E, VAL100C, VAL104C, VAL125E, VAL160E
• D-E: ARG169D, ARG169E, GLU171D, GLU171E, MET170E, THR172E
• D-F: ALA120D, ALA128D, ARG105F, GLN126D, GLY108F, GLY121D, HIS123D, ILE112F, ILE129D, ILE130D, LEU132D, LEU132F, LEU135D, LEU135F, LEU158D, LEU97F, LEU98F, LYS131D, LYS99F, MET127D, PHE103F, PHE167D, PRO101F, SER168D, SER96F, THR136F, TYR124D, VAL100F, VAL104F, VAL125D
• E-F: ALA134E, ALA134F, ALA159F, ALA161E, ALA161F, ALA179E, ALA179F, ALA182E, ALA182F, ALA183E, ALA183F, ALA195E, ALA195F, ALA206E, ALA206F, ALA95E, ALA95F, ARG105E, ARG105F, ARG156E, ARG156F, ARG169E, ARG169F, ARG196E, ARG196F, ARG197E, ARG197F, ARG215E, ARG215F, ASN142E, ASN142F, ASN189E, ASN189F, ASP180E, ASP180F, ASP186E, ASP186F, ASP207E, ASP207F, CYS184E, CYS184F, GLN199E, GLN199F, GLN94E, GLN94F, GLU163E, GLU163F, GLU171E, GLU171F, GLU200E, GLU200F, GLY133E, GLY133F, GLY137E, GLY137F, GLY178E, GLY178F, GLY185E, GLY185F, GLY190E, GLY190F, GLY198E, GLY198F, GLY204E, GLY204F, GLY208E, GLY208F, HIS143E, HIS143F, HIS3E, HIS3F, ILE175E, ILE175F, ILE187E, ILE187F, ILE188E, ILE188F, ILE201E, ILE201F, LEU144E, LEU144F, LEU174E, LEU174F, LEU191E, LEU191F, LEU202E, LEU202F, LEU203E, LEU203F, LEU216E, LEU216F, LEU217E, LEU217F, LEU97E, LEU97F, LYS173E, LYS173F, LYS212E, LYS212F, LYS99E, MET170E, MET170F, MET209E, MET209F, MET4E, MET4F, PHE103E, PHE103F, PRO164E, PRO164F, PRO192E, PRO192F, PRO205E, PRO205F, SER168E, SER168F, SER194E, SER194F, SER2E, SER2F, SER96E, SER96F, THR136E, THR136F, THR138E, THR138F, THR172E, THR172F, THR176E, THR176F, THR181E, THR181F, TRP177E, TRP177F, TRP214E, TRP214F, TYR102E, TYR102F, TYR139E, TYR139F, TYR141E, TYR141F, VAL106E, VAL106F, VAL140E, VAL140F, VAL160E, VAL160F, VAL162E, VAL162F, VAL165E, VAL165F, VAL166E, VAL166F, VAL193E, VAL193F, VAL210E, VAL210F
• E-H: ASN153H, GLY208E, SER211E
• F-H: ALA120H, ALA159F, ARG156F, ASN153F, ASN153H, ASP157F, GLY121H, GLY154F, HIS123H, HIS152H, TYR124H, VAL160F
• F-I: ALA120F, ALA182I, ALA183I, ASP180I, GLY121F, ILE119F, THR181I
• F-J: ALA159F, ARG156F, ASN153F, ASP157F, GLN107J, GLY154F, HIS123F, HIS152F, LEU144J, LEU155F, LEU158F, MET127F, PHE103J, PRO101J, SER2J, TYR102J, TYR124F, VAL100J, VAL104J
• G-H: ALA134G, ALA134H, ALA159G, ALA159H, ALA161G, ALA161H, ALA179G, ALA179H, ALA182G, ALA182H, ALA183G, ALA183H, ALA195G, ALA195H, ALA206G, ALA206H, ALA95G, ALA95H, ARG105G, ARG105H, ARG156G, ARG156H, ARG169G, ARG169H, ARG196G, ARG196H, ARG197G, ARG197H, ARG215G, ARG215H, ASN142G, ASN142H, ASN189G, ASN189H, ASP180G, ASP180H, ASP186G, ASP186H, ASP207G, ASP207H, CYS184G, CYS184H, GLN199G, GLN199H, GLN94G, GLN94H, GLU163G, GLU163H, GLU171G, GLU171H, GLU200G, GLU200H, GLY133G, GLY133H, GLY137G, GLY137H, GLY178G, GLY178H, GLY185G, GLY185H, GLY190G, GLY190H, GLY198G, GLY198H, GLY1H, GLY204G, GLY204H, GLY208G, GLY208H, HIS143G, HIS143H, HIS3G, HIS3H, ILE175G, ILE175H, ILE187G, ILE187H, ILE188G, ILE188H, ILE201G, ILE201H, LEU144G, LEU144H, LEU174G, LEU174H, LEU191G, LEU191H, LEU202G, LEU202H, LEU203G, LEU203H, LEU216G, LEU216H, LEU217G, LEU217H, LEU97G, LEU97H, LYS173G, LYS173H, LYS212H, LYS99H, MET170G, MET170H, MET209G, MET209H, MET4G, MET4H, PHE103G, PHE103H, PRO164G, PRO164H, PRO192G, PRO192H, PRO205G, PRO205H, SER168G, SER168H, SER194G, SER194H, SER2G, SER2H, SER96G, SER96H, THR136G, THR136H, THR138G, THR138H, THR145G, THR172G, THR172H, THR176G, THR176H, THR181G, THR181H, TRP177G, TRP177H, TRP214G, TRP214H, TYR102G, TYR102H, TYR139G, TYR139H, TYR141G, TYR141H, VAL106G, VAL106H, VAL140G, VAL140H, VAL160G, VAL160H, VAL162G, VAL162H, VAL165G, VAL165H, VAL166G, VAL166H, VAL193G, VAL193H, VAL210G, VAL210H
• G-I: ALA120I, ALA128I, ALA159I, ARG105G, ARG156I, ASP157I, GLY108G, GLY121I, HIS123I, ILE112G, ILE129I, LEU132G, LEU132I, LEU135I, LEU155I, LEU158I, LEU97G, LEU98G, LYS131I, LYS99G, MET127I, PHE167I, PRO101G, SER168I, SER96G, THR136G, TYR124I, VAL100G, VAL104G, VAL125I, VAL160I, VAL166I
• G-K: ALA120G, ALA128G, ARG105K, ARG111K, GLN107K, GLN126G, GLY108K, GLY121G, HIS123G, ILE112K, ILE119G, ILE129G, ILE130G, LEU132G, LEU132K, LEU135G, LEU158G, LEU97K, LEU98K, LYS131G, LYS99K, MET127G, PHE103K, PHE167G, PRO101K, SER168G, SER96K, THR136K, TYR124G, VAL100K, VAL104K, VAL125G
• G-L: ARG169G, ARG169L, GLU171G, GLU171L, MET170L, SER168L
• H-I: ARG169H, ARG169I, GLU171H, GLU171I, MET170I, SER168I, THR172I
• H-J: ALA116H, ALA120H, ALA128H, ALA159H, ARG105J, ARG111J, ARG169H, GLN126H, GLY108J, GLY121H, GLY122H, HIS123H, ILE112J, ILE119H, ILE129H, ILE130H, LEU132H, LEU132J, LEU135H, LEU158H, LEU97J, LEU98J, LYS131H, LYS99J, MET127H, PHE103J, PHE167H, PRO101J, SER168H, SER96J, THR136J, TYR124H, VAL100J, VAL104J, VAL125H, VAL160H, VAL166H
• H-L: ALA120L, ALA128L, ARG105H, ARG111H, ARG169L, GLY108H, GLY121L, HIS123L, ILE112H, ILE119L, ILE129L, ILE130L, LEU132H, LEU132L, LEU135L, LEU158L, LEU97H, LEU98H, LYS131L, LYS99H, MET127L, PHE103H, PHE167L, PRO101H, SER168L, SER96H, THR136H, TYR124L, VAL100H, VAL104H, VAL125L, VAL160L
• I-J: ALA134I, ALA134J, ALA159I, ALA159J, ALA161I, ALA161J, ALA179I, ALA179J, ALA182I, ALA182J, ALA183I, ALA183J, ALA195I, ALA195J, ALA206I, ALA206J, ALA95I, ALA95J, ARG105I, ARG105J, ARG156I, ARG156J, ARG169I, ARG169J, ARG196I, ARG196J, ARG197I, ARG197J, ARG215I, ARG215J, ASN142I, ASN142J, ASN189I, ASN189J, ASP180I, ASP180J, ASP186I, ASP186J, ASP207I, ASP207J, CYS184I, CYS184J, GLN199I, GLN199J, GLN94I, GLN94J, GLU163I, GLU163J, GLU171I, GLU171J, GLU200I, GLU200J, GLY133I, GLY133J, GLY137I, GLY137J, GLY178I, GLY178J, GLY185I, GLY185J, GLY190I, GLY190J, GLY198I, GLY198J, GLY204I, GLY204J, GLY208I, GLY208J, HIS143I, HIS143J, HIS3I, HIS3J, ILE175I, ILE175J, ILE187I, ILE187J, ILE188I, ILE188J, ILE201I, ILE201J, LEU144I, LEU144J, LEU174I, LEU174J, LEU191I, LEU191J, LEU202I, LEU202J, LEU203I, LEU203J, LEU216I, LEU216J, LEU217I, LEU217J, LEU97I, LEU97J, LYS173I, LYS173J, LYS212I, LYS99I, LYS99J, MET170I, MET170J, MET209I, MET209J, MET4I, MET4J, PHE103I, PHE103J, PRO164I, PRO164J, PRO192I, PRO192J, PRO205I, PRO205J, SER168I, SER168J, SER194I, SER194J, SER2I, SER2J, SER96I, SER96J, THR136I, THR136J, THR138I, THR138J, THR172I, THR172J, THR176I, THR176J, THR181I, THR181J, TRP177I, TRP177J, TRP214I, TRP214J, TYR102I, TYR102J, TYR139I, TYR139J, TYR141I, TYR141J, VAL106I, VAL106J, VAL140I, VAL140J, VAL160I, VAL160J, VAL162I, VAL162J, VAL165I, VAL165J, VAL166I, VAL166J, VAL193I, VAL193J, VAL210I, VAL210J
• I-K: ALA120K, ALA128K, ALA159K, ARG105I, ARG169K, GLN126K, GLY108I, GLY121K, HIS123K, ILE112I, ILE129K, LEU132I, LEU132K, LEU135K, LEU158K, LEU97I, LEU98I, LYS131K, LYS99I, MET127K, PHE167K, PRO101I, SER168K, SER96I, THR136I, TYR124K, VAL100I, VAL104I, VAL125K, VAL160K, VAL166K
• J-K: ARG169J, ARG169K, GLU171J, GLU171K, MET170K, THR172K
• J-L: ALA120J, ALA128J, ALA159J, ARG105L, ARG111L, ARG169J, GLN126J, GLY108L, GLY121J, HIS123J, ILE112L, ILE119J, ILE129J, ILE130J, LEU132J, LEU132L, LEU135J, LEU158J, LEU97L, LEU98L, LYS131J, LYS99L, MET127J, PHE167J, PRO101L, SER168J, SER96L, THR136L, TYR124J, VAL100L, VAL104L, VAL125J, VAL160J, VAL166J
• K-L: ALA134K, ALA134L, ALA159K, ALA159L, ALA161K, ALA161L, ALA179K, ALA179L, ALA182K, ALA182L, ALA183K, ALA183L, ALA195K, ALA195L, ALA206K, ALA206L, ALA95K, ALA95L, ARG105K, ARG105L, ARG156K, ARG156L, ARG169K, ARG169L, ARG196L, ARG197K, ARG197L, ARG215K, ARG215L, ASN142K, ASN142L, ASN189K, ASN189L, ASP180K, ASP180L, ASP186K, ASP186L, ASP207K, ASP207L, CYS184K, CYS184L, GLN199K, GLN199L, GLN94K, GLN94L, GLU163K, GLU163L, GLU171K, GLU171L, GLU200K, GLU200L, GLY133K, GLY133L, GLY137K, GLY137L, GLY178K, GLY178L, GLY185K, GLY185L, GLY190K, GLY190L, GLY198K, GLY198L, GLY204K, GLY204L, GLY208K, GLY208L, HIS143K, HIS143L, HIS3K, HIS3L, ILE175K, ILE175L, ILE187K, ILE187L, ILE188K, ILE188L, ILE201K, ILE201L, LEU144K, LEU144L, LEU174K, LEU174L, LEU191K, LEU191L, LEU202K, LEU202L, LEU203K, LEU203L, LEU216K, LEU216L, LEU217K, LEU217L, LEU97K, LEU97L, LYS173K, LYS173L, LYS212K, LYS99L, MET170K, MET170L, MET209K, MET209L, MET4K, MET4L, PHE103K, PHE103L, PRO164K, PRO164L, PRO192K, PRO192L, PRO205K, PRO205L, SER168K, SER168L, SER194K, SER194L, SER2K, SER2L, SER96K, SER96L, THR136K, THR136L, THR138K, THR138L, THR172K, THR172L, THR176K, THR176L, THR181K, THR181L, TRP177K, TRP177L, TRP214K, TRP214L, TYR102K, TYR102L, TYR139K, TYR139L, TYR141K, TYR141L, VAL106K, VAL106L, VAL140K, VAL140L, VAL160K, VAL160L, VAL162K, VAL162L, VAL165K, VAL165L, VAL166K, VAL166L, VAL193K, VAL193L, VAL210K, VAL210L