2GXA

crystal structure of papillomavirus e1 hexameric helicase with ssdna and mgadp

• Total interactions analyzed: 91
• Total true interactions: 23
• Strongest Interaction:
  • Chains: A-K
  • Int. Res.: 28
  • Norm. En. per Res.: -3.7737
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-30.3006	-75.6574	-269.472	-375.43	164	20	9	13006	6	54	64
A-E	0.0	-7.3529	-2.8312	-10.1841	7	0	0	210	0	3	4
A-F	0.0	-62.8503	-171.813	-234.6633	116	11	5	8079	4	37	65
A-K	-5.8931	-41.2196	-58.5496	-105.6623	28	7	0	2195	3	21	16
B-C	-84.2497	-82.983	-315.849	-483.0817	167	20	10	14633	5	56	69
B-J	0.0	5.2815	-10.2221	-4.9406	19	0	0	679	1	12	11
B-K	0.0	85.396	-47.1872	38.2088	24	7	1	2268	1	23	20
C-D	-54.4682	-77.2357	-297.767	-429.4709	167	22	10	14454	8	49	65
C-G	0.0	0.0	-0.1313	-0.1313	6	0	0	31	0	4	3
D-E	-57.5418	-45.5919	-300.548	-403.6817	149	19	10	13359	6	46	64
D-F	0.0	0.0	-0.0061	-0.0061	2	0	0	5	0	0	3
D-G	0.0	-1.0013	1.1486	0.1473	13	3	0	453	0	9	8
D-L	-5.8135	15.5491	-31.8026	-22.067	42	3	0	1904	0	18	16
E-F	-19.3608	-28.0277	-268.5	-315.8884	148	25	8	11885	2	44	57
E-K	0.0	0.0	-0.331	-0.331	7	0	0	77	0	6	2
E-L	-7.6057	-14.8473	-32.6103	-55.0633	35	7	0	1608	2	18	18
F-K	-8.6716	0.0	-49.4493	-58.1209	39	8	0	2408	0	11	9
G-H	-63.3002	-93.2914	-305.796	-462.3876	163	18	10	14202	6	54	68
G-L	-6.0615	-60.0175	-187.303	-253.382	133	9	4	8785	3	52	61
H-I	-66.9891	-83.2721	-319.113	-469.3742	163	26	9	14537	7	52	68
I-J	-52.3387	-39.7626	-272.462	-364.5632	148	20	11	12727	2	44	62
J-K	-46.2648	-36.5014	-264.916	-347.6822	154	21	7	12365	3	45	59
K-L	-3.7294	-35.8855	-179.805	-219.4198	142	8	6	9083	2	45	56

Interface residues

• A-B: ALA326A, ALA332A, ALA336A, ALA339A, ALA350A, ALA355A, ALA362A, ALA371B, ALA375B, ALA458A, ALA467A, ALA470B, ALA474A, ALA475A, ALA480A, ALA483A, ALA495B, ALA509B, ALA510B, ALA515B, ARG366A, ARG366B, ARG370B, ARG493B, ARG505B, ARG538B, ASN352A, ASN414B, ASN436A, ASN444A, ASN459A, ASN494B, ASN523A, ASN558A, ASP312B, ASP360B, ASP471B, ASP478A, ASP479A, ASP489B, ASP497B, ASP504B, ASP550A, CYS361B, CYS484A, CYS548A, GLN318B, GLN354A, GLN374B, GLN512B, GLN555A, GLU327A, GLU328A, GLU334A, GLU372B, GLU551A, GLY314B, GLY433A, GLY438A, GLY451A, GLY452A, GLY498B, GLY553A, HIS357A, HIS357B, HIS367B, HIS448A, HIS460A, HIS460B, HIS463B, HIS482A, HIS507B, HIS536B, ILE331A, ILE423B, ILE447A, ILE503B, ILE513B, ILE524A, LEU337A, LEU349A, LEU369B, LEU376B, LEU418B, LEU442A, LEU455A, LEU466B, LEU476A, LEU492B, LEU533B, LEU535B, LYS330A, LYS356A, LYS356B, LYS359A, LYS359B, LYS417B, LYS421B, LYS425B, LYS426B, LYS439A, LYS461A, LYS506A, LYS506B, LYS508B, LYS514B, MET316A, MET316B, MET364B, MET441A, PHE311B, PHE313B, PHE348A, PHE457A, PHE464A, PHE464B, PHE557A, PRO424B, PRO434A, PRO435A, PRO500B, PRO556A, SER329A, SER353A, SER353B, SER440A, SER445A, SER453A, SER456A, SER462B, SER468A, SER502B, SER522A, SER537B, SER552A, THR315B, THR351A, THR351B, THR363A, THR363B, THR373B, THR437A, THR472A, THR481A, THR490B, THR521A, THR549A, TRP465A, TRP465B, TYR321B, TYR333A, TYR335A, TYR368B, TYR487B, TYR491B, TYR499B, TYR534B, VAL317B, VAL358A, VAL365B, VAL454A, VAL477A, VAL501B, VAL511B
• A-E: GLU327E, GLU328E, LYS330E, LYS359E, LYS508A, SER329E, VAL358E
• A-F: ALA326F, ALA332F, ALA336F, ALA339F, ALA350F, ALA355F, ALA362F, ALA371A, ALA371F, ALA375A, ALA458F, ALA470A, ALA509A, ALA510A, ARG366A, ARG366F, ARG370A, ARG370F, ARG385F, ARG493A, ARG505A, ARG505F, ASN352F, ASN444F, ASN459F, ASN494A, ASN558F, ASP312A, ASP360A, ASP471A, ASP478F, ASP479F, ASP504A, CYS361A, GLN318A, GLN354F, GLN374A, GLN512A, GLN555F, GLU327F, GLU328F, GLU334F, GLU372A, GLY314A, GLY451F, GLY452F, GLY553F, HIS357A, HIS357F, HIS367A, HIS367F, HIS448F, HIS460F, HIS463A, HIS507A, HIS507F, ILE331F, ILE447F, ILE513A, ILE559F, LEU337F, LEU349F, LEU369A, LEU376A, LYS310A, LYS330F, LYS356A, LYS356F, LYS359A, LYS359F, LYS425A, LYS461A, LYS461F, LYS506A, LYS506F, LYS508A, LYS508F, MET316A, MET364A, MET441F, PHE311A, PHE313A, PHE348F, PHE457F, PRO500A, SER329F, SER353A, SER353F, SER440F, SER445F, SER453F, SER456F, SER462A, SER462F, SER502A, THR315A, THR351A, THR351F, THR363A, THR363F, THR373A, THR490A, THR560F, TRP465F, TYR321A, TYR333F, TYR335F, TYR368A, TYR487A, TYR491A, TYR499A, VAL317A, VAL358F, VAL365A, VAL454F, VAL511A
• A-K: ALA480A, ALA483A, ALA528K, ARG486A, ARG531A, ARG531K, ARG543K, ASN523A, ASP525K, ASP530A, ASP530K, GLN527K, GLU529A, GLU529K, GLU545K, HIS482A, HIS536K, ILE432K, ILE524A, LEU533K, PRO434A, PRO435A, SER537K, THR481A, THR541K, TYR532A, TYR532K, VAL526K
• B-C: ALA332B, ALA336B, ALA339B, ALA350B, ALA355B, ALA362B, ALA371C, ALA375C, ALA458B, ALA467B, ALA470C, ALA475B, ALA480B, ALA483B, ALA495C, ALA509C, ALA510C, ARG366B, ARG366C, ARG370C, ARG486C, ARG493C, ARG505B, ARG505C, ARG538C, ASN352B, ASN436B, ASN444B, ASN459B, ASN494C, ASN523B, ASN558B, ASP312C, ASP360C, ASP471C, ASP478B, ASP479B, ASP489C, ASP497C, ASP504C, ASP550B, CYS361C, CYS443B, CYS484B, CYS548B, GLN318C, GLN354B, GLN374C, GLN512C, GLN555B, GLU327B, GLU328B, GLU334B, GLU372C, GLU551B, GLU554B, GLY314C, GLY433B, GLY438B, GLY451B, GLY452B, GLY498C, GLY553B, HIS357B, HIS357C, HIS367C, HIS448B, HIS460B, HIS460C, HIS463B, HIS463C, HIS482B, HIS507B, HIS507C, HIS536C, ILE331B, ILE423C, ILE447B, ILE503C, ILE513C, ILE524B, LEU337B, LEU349B, LEU369C, LEU376C, LEU418C, LEU442B, LEU455B, LEU466C, LEU476B, LEU492C, LEU533C, LEU535C, LYS310C, LYS330B, LYS356B, LYS356C, LYS359B, LYS359C, LYS425C, LYS426C, LYS439B, LYS461B, LYS461C, LYS506B, LYS506C, LYS508B, LYS508C, LYS514C, MET316B, MET316C, MET364C, MET441B, PHE311C, PHE313C, PHE348B, PHE457B, PHE464B, PHE464C, PHE488C, PRO424C, PRO434B, PRO435B, PRO500C, SER329B, SER353B, SER440B, SER445B, SER453B, SER456B, SER462B, SER462C, SER468B, SER502C, SER522B, SER537C, SER552B, THR315C, THR351B, THR351C, THR363C, THR373C, THR437B, THR472B, THR481B, THR490C, THR521B, THR549B, TRP465B, TRP465C, TRP485B, TYR321C, TYR333B, TYR335B, TYR368C, TYR487B, TYR487C, TYR491C, TYR499C, TYR534C, VAL317C, VAL358B, VAL365C, VAL454B, VAL477B, VAL501C, VAL511C
• B-J: ALA483J, ALA528B, ARG486J, ARG531J, ARG543B, ASN523J, ASP525B, ASP530B, ASP530J, GLN527B, GLU529B, GLU529J, GLU545B, HIS482J, ILE432B, ILE524J, THR481J, THR541B, TYR532J
• B-K: ALA483K, ARG486B, ARG486K, ARG493B, ARG493K, ARG531B, ARG531K, ASP489B, ASP489K, ASP530B, ASP530K, GLU529B, GLU529K, HIS482B, HIS482K, HIS536K, LEU533B, LEU533K, THR490B, THR490K, TYR532B, TYR532K, TYR534B, TYR534K
• C-D: ALA332C, ALA336C, ALA339C, ALA350C, ALA355C, ALA371D, ALA375D, ALA458C, ALA467C, ALA474C, ALA475C, ALA480C, ALA483C, ALA495D, ALA509D, ALA510D, ALA515D, ARG366C, ARG366D, ARG370D, ARG486D, ARG493D, ARG505D, ARG538D, ASN352C, ASN436C, ASN444C, ASN459C, ASN494D, ASN523C, ASN558C, ASP312D, ASP360D, ASP471D, ASP478C, ASP479C, ASP489D, ASP497D, ASP504D, ASP550C, CYS361D, CYS443C, CYS484C, CYS548C, GLN318D, GLN354C, GLN374D, GLN512D, GLN555C, GLU327C, GLU328C, GLU334C, GLU372D, GLU551C, GLU554C, GLY314D, GLY433C, GLY438C, GLY451C, GLY452C, GLY498D, GLY553C, HIS357C, HIS357D, HIS367D, HIS448C, HIS460C, HIS460D, HIS463C, HIS463D, HIS482C, HIS507C, HIS507D, HIS536D, ILE331C, ILE423D, ILE447C, ILE503D, ILE513D, ILE524C, LEU337C, LEU349C, LEU369D, LEU376D, LEU418D, LEU442C, LEU455C, LEU466C, LEU466D, LEU469D, LEU476C, LEU492D, LEU533D, LEU535D, LYS310D, LYS330C, LYS356C, LYS356D, LYS359C, LYS359D, LYS417D, LYS425D, LYS426D, LYS439C, LYS461C, LYS461D, LYS506C, LYS506D, LYS508D, LYS514D, MET316C, MET316D, MET364D, MET441C, PHE311D, PHE313D, PHE348C, PHE457C, PHE464C, PHE464D, PHE488D, PRO424D, PRO434C, PRO435C, PRO500D, SER329C, SER353C, SER440C, SER445C, SER453C, SER456C, SER462C, SER462D, SER468C, SER502D, SER522C, SER537D, SER552C, THR315D, THR351C, THR351D, THR363D, THR373D, THR437C, THR472C, THR481C, THR490D, THR521C, THR549C, TRP465C, TRP465D, TYR321D, TYR333C, TYR335C, TYR368D, TYR487C, TYR487D, TYR491D, TYR499D, TYR534D, VAL317D, VAL358C, VAL365D, VAL454C, VAL477C, VAL501D, VAL511D
• C-G: ARG531G, ASP530G, GLU529G, GLU545C, PRO434C, PRO435C
• D-E: ALA332D, ALA336D, ALA339D, ALA350D, ALA355D, ALA362D, ALA371E, ALA375E, ALA458D, ALA467D, ALA475D, ALA480D, ALA483D, ALA509E, ALA510E, ARG366D, ARG366E, ARG370E, ARG493E, ARG505D, ARG505E, ARG538E, ASN352D, ASN436D, ASN444D, ASN459D, ASN494E, ASN523D, ASP312E, ASP360E, ASP471E, ASP478D, ASP479D, ASP489E, ASP497E, ASP504E, CYS361E, CYS484D, CYS548D, GLN318E, GLN354D, GLN374E, GLN512E, GLN555D, GLU327D, GLU328D, GLU334D, GLU372E, GLU554D, GLY314E, GLY438D, GLY451D, GLY452D, GLY498E, GLY553D, HIS357D, HIS357E, HIS367E, HIS448D, HIS460D, HIS460E, HIS463E, HIS482D, HIS507D, HIS507E, ILE331D, ILE447D, ILE503E, ILE513E, ILE524D, LEU337D, LEU349D, LEU369E, LEU376E, LEU442D, LEU455D, LEU466E, LEU476D, LEU492E, LEU533E, LYS310E, LYS330D, LYS356D, LYS356E, LYS359D, LYS359E, LYS425E, LYS426E, LYS439D, LYS461D, LYS461E, LYS506D, LYS506E, LYS508D, LYS508E, MET364E, MET441D, PHE311E, PHE313E, PHE348D, PHE457D, PHE464D, PHE464E, PRO424E, PRO434D, PRO435D, PRO500E, SER329D, SER353D, SER353E, SER440D, SER445D, SER453D, SER456D, SER462D, SER462E, SER468D, SER502E, SER522D, SER537E, SER552D, THR315E, THR351D, THR351E, THR363E, THR373E, THR437D, THR472D, THR481D, THR490E, THR521D, THR549D, TRP465D, TRP465E, TYR321E, TYR333D, TYR335D, TYR368E, TYR487E, TYR491E, TYR499E, TYR534E, VAL317E, VAL358D, VAL365E, VAL454D, VAL477D, VAL501E, VAL511E
• D-F: HIS507D, HIS507F
• D-G: ALA528D, ARG531D, ARG531G, ASP530D, ASP530G, GLN527D, GLU529D, HIS536D, HIS536G, LEU533D, LEU533G, TYR534D, TYR534G
• D-L: ALA480L, ALA483D, ALA483L, ALA528D, ARG486D, ARG486L, ARG531D, ARG531L, ARG543D, ASN436L, ASN523D, ASN523L, ASP479L, ASP525D, ASP525L, ASP530D, GLN527D, GLN546L, GLU529D, GLU529L, GLU545D, GLU545L, GLY433L, HIS482D, HIS482L, ILE432D, ILE432L, ILE524D, ILE524L, LYS439L, PRO434D, PRO434L, PRO435D, PRO435L, PRO547L, SER522L, THR437L, THR481D, THR481L, TRP485L, TYR532D, VAL526D
• E-F: ALA332E, ALA336E, ALA339E, ALA350E, ALA355E, ALA362E, ALA362F, ALA371F, ALA375F, ALA458E, ALA467E, ALA474E, ALA475E, ALA483E, ALA509F, ALA510F, ARG366E, ARG366F, ARG370F, ARG493F, ARG505E, ARG505F, ARG538F, ASN352E, ASN436E, ASN444E, ASN459E, ASN494F, ASN523E, ASN558E, ASP312F, ASP360F, ASP478E, ASP479E, ASP497F, ASP504F, ASP550E, CYS361F, CYS484E, CYS548E, GLN318F, GLN354E, GLN374F, GLN512F, GLN555E, GLU327E, GLU328E, GLU334E, GLU372F, GLU551E, GLY314F, GLY438E, GLY451E, GLY452E, GLY498F, GLY553E, HIS357E, HIS357F, HIS367F, HIS448E, HIS460E, HIS460F, HIS463F, HIS507E, HIS507F, ILE331E, ILE423F, ILE447E, ILE503F, ILE513F, ILE559E, LEU337E, LEU349E, LEU369F, LEU376F, LEU442E, LEU455E, LEU466F, LEU476E, LEU492F, LEU533F, LYS310F, LYS330E, LYS356E, LYS356F, LYS359E, LYS359F, LYS425F, LYS426F, LYS439E, LYS461E, LYS461F, LYS506E, LYS506F, LYS508E, LYS508F, MET316E, MET316F, MET364F, MET441E, PHE311F, PHE313F, PHE348E, PHE457E, PHE464E, PHE464F, PHE557E, PRO424F, PRO435E, PRO500F, SER329E, SER353E, SER440E, SER445E, SER453E, SER456E, SER462E, SER462F, SER468E, SER502F, SER537F, SER552E, THR315F, THR351E, THR351F, THR363F, THR373F, THR472E, THR481E, THR490F, THR521E, THR549E, TRP465E, TRP465F, TYR321F, TYR333E, TYR335E, TYR368F, TYR487F, TYR491F, TYR499F, TYR534F, VAL317F, VAL358E, VAL365F, VAL454E, VAL501F, VAL511F
• E-K: ALA483E, ARG486E, GLU551K, HIS482E, ILE524E, SER552K, THR481E
• E-L: ALA483E, ALA528L, ARG486E, ARG493E, ARG531E, ARG531L, ARG543L, ASN406L, ASP489E, ASP525L, ASP530E, ASP530L, CYS484E, GLN527L, GLN546L, GLU408L, GLU529E, GLU529L, GLU545L, HIS460E, HIS482E, HIS536L, ILE407L, LEU533E, LEU533L, PHE457E, PHE542L, SER537L, THR411L, THR490E, THR541L, TYR487E, TYR491E, TYR532E, TYR534E
• F-K: ALA480F, ALA483F, ARG486F, ARG531F, ASN403K, ASN406K, ASN436K, ASN523F, ASP479F, ASP550K, CYS484F, CYS548K, GLN405K, GLN546K, GLU408K, GLU529F, GLU545K, GLU551K, HIS460F, HIS482F, ILE524F, LYS461F, PHE401K, PHE457F, PHE557K, PRO434K, PRO435F, PRO435K, PRO547K, PRO556K, THR400K, THR437K, THR481F, THR490F, THR549K, TRP485F, TYR404K, TYR487F, TYR532F
• G-H: ALA332G, ALA336G, ALA350G, ALA355G, ALA362G, ALA362H, ALA371H, ALA375H, ALA458G, ALA467G, ALA475G, ALA480G, ALA483G, ALA495H, ALA509H, ALA510H, ARG366G, ARG366H, ARG370H, ARG493H, ARG505G, ARG505H, ARG538H, ASN352G, ASN436G, ASN444G, ASN459G, ASN494H, ASN523G, ASN558G, ASP312H, ASP360H, ASP471H, ASP478G, ASP479G, ASP489H, ASP497H, ASP504H, ASP550G, CYS361H, CYS443G, CYS484G, CYS548G, GLN318H, GLN354G, GLN374H, GLN512H, GLN555G, GLU327G, GLU328G, GLU334G, GLU372H, GLU551G, GLU554G, GLY314H, GLY433G, GLY438G, GLY451G, GLY452G, GLY553G, HIS357G, HIS357H, HIS367H, HIS448G, HIS460G, HIS460H, HIS463G, HIS463H, HIS482G, HIS507G, HIS507H, HIS536H, ILE331G, ILE423H, ILE447G, ILE503H, ILE513H, ILE524G, LEU337G, LEU349G, LEU369H, LEU376H, LEU418H, LEU442G, LEU455G, LEU466H, LEU476G, LEU492H, LEU533H, LEU535H, LYS310H, LYS330G, LYS356G, LYS356H, LYS359G, LYS359H, LYS425H, LYS426H, LYS439G, LYS461G, LYS461H, LYS506G, LYS506H, LYS508G, LYS508H, LYS514H, MET316G, MET316H, MET364H, MET441G, PHE311H, PHE313H, PHE348G, PHE457G, PHE464G, PHE464H, PHE488H, PRO424H, PRO434G, PRO435G, PRO500H, SER329G, SER353G, SER353H, SER440G, SER445G, SER453G, SER456G, SER462G, SER462H, SER468G, SER502H, SER522G, SER537H, SER552G, THR315H, THR351G, THR351H, THR363H, THR373H, THR437G, THR472G, THR481G, THR490H, THR521G, THR549G, TRP465G, TRP465H, TYR321H, TYR333G, TYR335G, TYR368H, TYR487H, TYR491H, TYR499H, TYR534H, VAL317H, VAL358G, VAL365H, VAL454G, VAL477G, VAL501H, VAL511H
• G-L: ALA326L, ALA332L, ALA336L, ALA350L, ALA355L, ALA362G, ALA362L, ALA371G, ALA375G, ALA458L, ALA470G, ALA509G, ALA510G, ARG366G, ARG366L, ARG370G, ARG385L, ARG486G, ARG493G, ARG505G, ARG531G, ARG538G, ASN352L, ASN436L, ASN459L, ASN494G, ASP312G, ASP360G, ASP471G, ASP478L, ASP479L, ASP489G, ASP497G, ASP504G, ASP550L, CYS361G, GLN318G, GLN354L, GLN374G, GLN512G, GLN540G, GLN555L, GLU327L, GLU328L, GLU334L, GLU372G, GLU551L, GLY314G, GLY451L, GLY452L, GLY498G, GLY553L, HIS357G, HIS357L, HIS367G, HIS448L, HIS460L, HIS463G, HIS463L, HIS507G, HIS507L, ILE331L, ILE423G, ILE513G, LEU337L, LEU349L, LEU369G, LEU376G, LEU442L, LEU446L, LEU455L, LEU469L, LEU492G, LYS310G, LYS330L, LYS356G, LYS356L, LYS359G, LYS359L, LYS425G, LYS426G, LYS439L, LYS461G, LYS506L, LYS508G, LYS514G, MET316G, MET316L, MET364G, MET441L, PHE311G, PHE313G, PHE348L, PHE449L, PHE457L, PHE464L, PHE488G, PRO424G, PRO500G, SER329L, SER353G, SER353L, SER445L, SER453L, SER456L, SER462G, SER462L, SER502G, SER537G, SER552L, THR315G, THR351G, THR351L, THR363G, THR363L, THR373G, THR472L, THR490G, TRP465L, TYR321G, TYR333L, TYR335L, TYR368G, TYR487G, TYR491G, TYR499G, TYR534G, VAL317G, VAL358L, VAL365G, VAL454L, VAL501G, VAL511G
• H-I: ALA332H, ALA336H, ALA350H, ALA355H, ALA362H, ALA371I, ALA375I, ALA458H, ALA467H, ALA470I, ALA475H, ALA480H, ALA483H, ALA495I, ALA509I, ALA510I, ARG366H, ARG366I, ARG370I, ARG486I, ARG493I, ARG505H, ARG505I, ARG538I, ASN352H, ASN436H, ASN444H, ASN459H, ASN494I, ASN523H, ASN558H, ASP312I, ASP360I, ASP471I, ASP478H, ASP479H, ASP489I, ASP497I, ASP504I, ASP550H, CYS361I, CYS443H, CYS484H, CYS548H, GLN318I, GLN354H, GLN374I, GLN512I, GLN555H, GLU327H, GLU328H, GLU334H, GLU372I, GLU551H, GLU554H, GLY314I, GLY433H, GLY438H, GLY451H, GLY452H, GLY498I, GLY553H, HIS357H, HIS357I, HIS367I, HIS448H, HIS460H, HIS460I, HIS463H, HIS463I, HIS482H, HIS507H, HIS507I, HIS536I, ILE331H, ILE423I, ILE447H, ILE503I, ILE513I, ILE524H, LEU337H, LEU349H, LEU369I, LEU376I, LEU418I, LEU442H, LEU455H, LEU466I, LEU476H, LEU492I, LEU533I, LEU535I, LYS310I, LYS330H, LYS356H, LYS356I, LYS359H, LYS359I, LYS417I, LYS425I, LYS426I, LYS439H, LYS461H, LYS461I, LYS506H, LYS506I, LYS508I, LYS514I, MET364I, MET441H, PHE311I, PHE313I, PHE348H, PHE457H, PHE464H, PHE464I, PHE488I, PRO424I, PRO434H, PRO435H, PRO500I, SER329H, SER353H, SER440H, SER445H, SER453H, SER456H, SER462H, SER462I, SER468H, SER502I, SER522H, SER537I, SER552H, THR315I, THR351H, THR363I, THR373I, THR437H, THR472H, THR481H, THR490I, THR521H, THR549H, TRP465H, TRP465I, TRP485H, TYR321I, TYR333H, TYR335H, TYR368I, TYR487H, TYR487I, TYR491I, TYR499I, TYR534I, VAL317I, VAL358H, VAL365I, VAL454H, VAL477H, VAL501I, VAL511I
• I-J: ALA332I, ALA336I, ALA350I, ALA355I, ALA362I, ALA371J, ALA375J, ALA458I, ALA467I, ALA470J, ALA475I, ALA480I, ALA483I, ALA509J, ALA510J, ARG366I, ARG366J, ARG370J, ARG493J, ARG505I, ARG505J, ARG538J, ASN352I, ASN436I, ASN444I, ASN459I, ASN494J, ASN523I, ASP312J, ASP360J, ASP478I, ASP479I, ASP489J, ASP497J, ASP504J, CYS361J, CYS443I, CYS484I, CYS548I, GLN318J, GLN354I, GLN374J, GLN512J, GLN555I, GLU327I, GLU328I, GLU334I, GLU372J, GLU554I, GLY314J, GLY438I, GLY451I, GLY452I, GLY498J, GLY553I, HIS357I, HIS357J, HIS367J, HIS448I, HIS460I, HIS460J, HIS463J, HIS482I, HIS507I, HIS507J, ILE331I, ILE447I, ILE503J, ILE513J, ILE559I, LEU337I, LEU349I, LEU369J, LEU376J, LEU442I, LEU455I, LEU466I, LEU466J, LEU476I, LEU492J, LEU533J, LYS310J, LYS330I, LYS356I, LYS356J, LYS359I, LYS359J, LYS425J, LYS426J, LYS439I, LYS461I, LYS461J, LYS506I, LYS506J, LYS508I, LYS508J, MET316J, MET364J, MET441I, PHE311J, PHE313J, PHE348I, PHE457I, PHE464I, PHE464J, PRO424J, PRO434I, PRO435I, PRO500J, SER329I, SER353I, SER440I, SER445I, SER453I, SER456I, SER462I, SER462J, SER468I, SER502J, SER522I, SER537J, SER552I, THR315J, THR351I, THR363J, THR373J, THR437I, THR472I, THR481I, THR490J, THR521I, THR549I, TRP465I, TRP465J, TYR321J, TYR333I, TYR335I, TYR368J, TYR487J, TYR491J, TYR499J, TYR534J, VAL317J, VAL358I, VAL454I, VAL477I, VAL501J, VAL511J
• J-K: ALA332J, ALA336J, ALA350J, ALA355J, ALA362J, ALA371K, ALA375K, ALA458J, ALA467J, ALA475J, ALA480J, ALA483J, ALA509K, ALA510K, ARG366J, ARG366K, ARG370K, ARG493K, ARG505J, ARG505K, ARG538K, ASN352J, ASN436J, ASN444J, ASN459J, ASN494K, ASN523J, ASN558J, ASP312K, ASP360K, ASP478J, ASP479J, ASP489K, ASP497K, ASP504K, ASP550J, CYS361K, CYS443J, CYS484J, CYS548J, GLN318K, GLN354J, GLN374K, GLN512K, GLU327J, GLU328J, GLU334J, GLU372K, GLU551J, GLY314K, GLY438J, GLY451J, GLY452J, GLY498K, HIS357J, HIS357K, HIS367K, HIS448J, HIS460J, HIS460K, HIS463J, HIS463K, HIS482J, HIS507J, HIS507K, ILE331J, ILE423K, ILE447J, ILE503K, ILE513K, ILE559J, LEU337J, LEU349J, LEU369K, LEU376K, LEU418K, LEU442J, LEU455J, LEU466K, LEU476J, LEU492K, LEU533K, LYS310K, LYS330J, LYS356J, LYS356K, LYS359J, LYS359K, LYS425K, LYS426K, LYS439J, LYS461J, LYS461K, LYS506J, LYS506K, LYS508J, LYS508K, MET316J, MET316K, MET364K, MET441J, PHE311K, PHE313K, PHE348J, PHE457J, PHE464J, PHE464K, PHE557J, PRO424K, PRO434J, PRO435J, PRO500K, SER329J, SER353J, SER353K, SER440J, SER445J, SER453J, SER456J, SER462J, SER462K, SER468J, SER502K, SER522J, SER537K, SER552J, THR315K, THR351J, THR351K, THR363K, THR373K, THR437J, THR472J, THR481J, THR490K, THR521J, THR549J, TRP465J, TRP465K, TYR321K, TYR333J, TYR335J, TYR368K, TYR487K, TYR491K, TYR499K, TYR534K, VAL317K, VAL358J, VAL365K, VAL454J, VAL477J, VAL501K, VAL511K
• K-L: ALA332K, ALA336K, ALA350K, ALA355K, ALA362K, ALA362L, ALA371L, ALA375L, ALA458K, ALA467K, ALA509L, ALA510L, ARG366L, ARG370L, ARG385K, ARG493L, ARG505K, ARG505L, ARG531L, ARG538L, ASN352K, ASN436K, ASN444K, ASN459K, ASN494L, ASN558K, ASP312L, ASP360L, ASP471K, ASP471L, ASP478K, ASP479K, ASP489L, ASP497L, ASP504L, ASP550K, CYS361L, GLN318L, GLN354K, GLN374L, GLN512L, GLN555K, GLU327K, GLU328K, GLU334K, GLU372L, GLU551K, GLU554K, GLY314L, GLY438K, GLY451K, GLY452K, GLY498L, GLY553K, HIS357K, HIS357L, HIS367L, HIS448K, HIS460K, HIS507K, HIS507L, HIS536L, ILE331K, ILE447K, ILE503L, ILE559K, LEU337K, LEU349K, LEU369L, LEU376L, LEU455K, LEU476K, LEU533L, LYS310L, LYS330K, LYS356K, LYS356L, LYS359K, LYS359L, LYS425L, LYS439K, LYS461K, LYS461L, LYS506K, LYS506L, LYS508K, LYS508L, MET316K, MET316L, MET364L, MET441K, PHE311L, PHE313L, PHE348K, PHE457K, PHE464K, PHE464L, PRO424L, PRO435K, PRO500L, PRO556K, SER329K, SER353K, SER353L, SER440K, SER445K, SER453K, SER456K, SER462K, SER462L, SER468K, SER502L, SER537L, SER552K, THR315L, THR351K, THR351L, THR363L, THR373L, THR437K, THR472K, THR481K, THR490L, THR549K, THR560K, TRP465K, TRP465L, TYR321L, TYR333K, TYR335K, TYR368L, TYR487L, TYR491L, TYR499L, TYR532L, TYR534L, VAL317L, VAL358K, VAL365L, VAL454K, VAL501L, VAL511L