2GTT

crystal structure of the rabies virus nucleoprotein-rna complex

• Total interactions analyzed: 276
• Total true interactions: 57
• Strongest Interaction:
  • Chains: N-P
  • Int. Res.: 5
  • Norm. En. per Res.: -6.21
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-43.93	-58.5586	-461.959	-564.4475	200	35	14	22707	4	53	64
A-C	-15.3667	-14.4633	-60.2922	-90.1222	24	2	3	2732	1	9	7
A-J	-26.4803	-12.4865	-62.7187	-101.6855	28	1	2	2988	0	13	8
A-K	-41.4924	-77.659	-464.573	-583.7243	209	38	15	23058	5	52	68
A-L	0.0	0.0	-0.1321	-0.1321	4	0	0	43	0	5	3
B-C	-20.7462	-56.4909	-477.311	-554.5481	206	40	14	23181	7	55	70
B-D	-10.4265	-15.4149	-60.2194	-86.0608	25	8	2	2774	1	13	8
B-K	-14.2959	-13.0757	-57.6342	-85.0057	25	5	2	2674	0	12	8
C-D	-41.518	-48.0477	-507.183	-596.7487	210	39	14	23168	5	56	62
C-E	-24.5343	-18.1943	-57.7243	-100.4529	26	2	2	2706	2	11	8
C-T	-7.1723	0.0			2
D-E	-51.2047	-65.966	-463.841	-581.0117	203	45	14	23248	7	52	66
D-F	-22.0582	-16.9781	-77.6116	-116.6479	26	5	3	3241	1	11	7
E-F	-46.5555	-68.168	-480.764	-595.4875	212	42	13	23336	6	53	72
E-G	-20.2035	-9.5245	-71.9615	-101.6894	27	6	2	3266	0	9	6
F-G	-40.6255	-60.2869	-469.235	-570.1475	204	30	13	22446	4	54	58
F-H	-22.6462	-8.9893	-56.5531	-88.1886	25	2	2	2610	0	8	6
F-Q	-7.2682	0.0			2
F-R	0.0	3.0682			2
G-H	-33.093	-54.7769	-481.471	-569.3409	205	40	13	22829	4	54	60
G-I	-24.2563	-11.2665	-56.6969	-92.2197	26	2	2	2740	0	9	6
G-P	0.0	0.0	-48.2305	-48.2305	35	3	3	2901	0	0	0
H-I	-33.4718	-63.7046	-459.601	-556.7773	210	41	15	23874	6	54	67
H-J	-18.6875	-19.0006	-62.8149	-100.5031	26	1	2	3004	2	12	8
H-O	0.0	0.0	-43.8457	-43.8457	33	6	2	2867	0	0	0
H-P	0.0	0.0	-0.0042	-0.0042	3	0	0	7	0	2	1
I-J	-43.5648	-61.1123	-479.704	-584.381	208	46	13	23848	7	54	69
I-K	-6.2938	-11.81	-65.8581	-83.9619	27	1	2	2954	0	10	7
I-N	-8.5589	0.0	-60.5964	-69.1553	44	4	3	3284	0	2	2
I-O	0.0	0.0	-0.0105	-0.0105	4	0	0	11	0	2	2
J-K	-35.3041	-59.5204	-499.856	-594.6805	204	41	14	23303	5	51	66
J-M	0.0	0.0	-45.7359	-45.7359	39	2	3	3121	0	1	1
J-N	0.0	0.0	-0.2251	-0.2251	5	0	0	55	0	5	3
K-L	-10.6401	0.0	-69.3625	-80.0026	44	7	4	3522	0	2	2
K-M	0.0	4.4286	-0.1801	4.2485	4	0	0	66	0	5	2
L-M	-38.4488	-60.3333	-459.97	-558.7521	211	44	13	23196	7	55	64
L-N	-19.1889	-21.8135	-76.8674	-117.8697	27	3	3	3242	2	12	9
L-U	-23.7741	-20.3806			6
L-V	-25.8195	-62.2575			28
M-N	-33.9731	-64.3057	-518.204	-616.4828	226	47	15	24472	6	56	69
M-O	-6.0324	-11.9179	-85.3931	-103.3434	28	12	3	3736	0	11	7
M-V	-16.4847	-12.6351			6
N-O	-50.8672	-53.2381	-481.845	-585.9503	201	35	14	22203	6	52	62
N-P	-22.5467	-8.5031	0.0	-31.0498	5	0	0	0	0	0	0
O-P	-34.3221	-40.0616	-137.2	-211.5836	125	31	7	9961	0	27	24
O-Q	-15.812	-14.3918			5
P-Q	-42.0351	-48.3734			31
P-R	-15.8132	-20.0856			6
Q-R	-52.3751	-58.0264			28
Q-S	-10.5116	-15.4325			6
R-S	-38.1247	-75.7982			29
R-T	-16.1192	-10.5442			8
S-T	-32.9483	-40.4123			27
S-U	-17.0521	-11.4329			6
T-U	-48.0404	-52.0765			29
T-V	-15.7298	-8.7279			4
U-V	-43.0899	-67.3444			34

Interface residues

• A-B: ALA176B, ALA195A, ALA253B, ALA256A, ALA256B, ALA280B, ALA331A, ALA332A, ALA334A, ALA404A, ALA63A, ARG168B, ARG216B, ARG254B, ARG270A, ARG270B, ARG271B, ARG323B, ARG357B, ARG358B, ARG361B, ARG400A, ARG400B, ARG408B, ARG415A, ARG422B, ARG423B, ASN11A, ASN12A, ASN164B, ASN196A, ASN250B, ASN264A, ASN326B, ASN412A, ASN430B, ASN436A, ASN443A, ASP24A, ASP362B, CYS317B, CYS333A, GLN13A, GLN156A, GLN171B, GLN248B, GLN25A, GLN277B, GLN321B, GLN432B, GLU174B, GLU20A, GLU218B, GLU255A, GLU255B, GLU266A, GLU266B, GLU267A, GLU267B, GLU268A, GLU268B, GLU274B, GLU278B, GLU337A, GLU347B, GLU348B, GLU356B, GLU365B, GLU398B, GLU403A, GLU440A, GLY155A, GLY244B, GLY276B, GLY316B, GLY320B, GLY342A, GLY343A, GLY346B, GLY351B, GLY353B, GLY413A, GLY414A, HIS184B, HIS219B, HIS262A, HIS26A, HIS283B, HIS307A, HIS336A, HIS420A, HIS431B, ILE172B, ILE200A, ILE21A, ILE22A, ILE246B, ILE249B, ILE257A, ILE257B, ILE269A, ILE269B, ILE287B, ILE330A, ILE409A, ILE421A, ILE6A, LEU17A, LEU239B, LEU251B, LEU258A, LEU258B, LEU311A, LEU325B, LEU341A, LEU345B, LEU416A, LYS162A, LYS180B, LYS18A, LYS247B, LYS263A, LYS263B, LYS297A, LYS352B, LYS417A, LYS417B, LYS444A, LYS64A, LYS9A, MET272B, MET319B, MET338A, MET410A, MET411A, PHE178B, PHE242B, PHE260A, PHE261A, PHE265A, PHE265B, PHE273A, PHE273B, PHE286B, PHE349B, PHE350B, PHE355B, PHE359B, PHE360B, PHE441A, PHE8A, PRO135B, PRO177B, PRO19A, PRO201A, PRO275B, PRO282B, PRO335A, PRO402A, PRO402B, PRO435A, SER16A, SER198A, SER284B, SER339A, SER401A, SER426B, SER447A, SER448A, THR175B, THR199A, THR243B, THR252A, THR252B, THR279B, THR354B, THR399B, THR407A, THR445A, TRP197A, TYR233B, TYR259A, TYR300B, TYR318B, TYR344A, TYR344B, TYR369B, TYR406A, TYR446A, VAL10A, VAL23A, VAL240B, VAL281B, VAL308A, VAL322B, VAL340A, VAL405A, VAL405B, VAL427B, VAL7A
• A-C: ARG358C, ARG361C, ASN11A, ASN12A, ASP362C, GLN13A, GLN367C, GLU363C, GLU365C, GLU370C, ILE6A, LEU17A, LEU366C, LYS18A, LYS364C, LYS9A, PHE359C, PHE360C, PHE8A, SER16A, VAL10A, VAL14A, VAL15A, VAL7A
• A-J: ARG357A, ARG358A, ARG361A, ASN11J, ASN12J, ASP362A, GLN13J, GLN367A, GLU20J, GLU356A, GLU363A, GLU365A, GLU370A, ILE6J, LEU17J, LEU366A, LYS18J, LYS364A, LYS5J, LYS9J, PHE359A, PHE360A, PHE8J, SER16J, VAL10J, VAL14J, VAL15J, VAL7J
• A-K: ALA176A, ALA195K, ALA253A, ALA256A, ALA256K, ALA280A, ALA331K, ALA332K, ALA334K, ALA372A, ALA404K, ARG168A, ARG216A, ARG254A, ARG270A, ARG270K, ARG271A, ARG323A, ARG357A, ARG358A, ARG361A, ARG400A, ARG400K, ARG408A, ARG415K, ARG422A, ARG423A, ASN11K, ASN12K, ASN164A, ASN196K, ASN250A, ASN264K, ASN326A, ASN412K, ASN430A, ASN436K, ASN443K, ASP24K, ASP362A, CYS317A, CYS333K, GLN13K, GLN156K, GLN171A, GLN248A, GLN25K, GLN277A, GLN321A, GLN432A, GLU174A, GLU20K, GLU218A, GLU255A, GLU255K, GLU266A, GLU266K, GLU267A, GLU267K, GLU268A, GLU268K, GLU274A, GLU278A, GLU337K, GLU347A, GLU348A, GLU356A, GLU365A, GLU398A, GLU403K, GLU440K, GLY155K, GLY244A, GLY276A, GLY296K, GLY316A, GLY320A, GLY342K, GLY343K, GLY346A, GLY351A, GLY353A, GLY413K, GLY414K, HIS184A, HIS219A, HIS262K, HIS26K, HIS283A, HIS307K, HIS336K, HIS431A, ILE172A, ILE200K, ILE21K, ILE22K, ILE246A, ILE249A, ILE257A, ILE257K, ILE269A, ILE269K, ILE287A, ILE330K, ILE409K, ILE421K, ILE6K, LEU17K, LEU239A, LEU251A, LEU258A, LEU258K, LEU311K, LEU325A, LEU341K, LEU345A, LEU416K, LEU442K, LYS162K, LYS180A, LYS18K, LYS247A, LYS263A, LYS263K, LYS297K, LYS352A, LYS417A, LYS417K, LYS444K, LYS5K, LYS64K, LYS9K, MET272A, MET319A, MET338K, MET410K, MET411K, PHE178A, PHE242A, PHE245A, PHE260A, PHE260K, PHE261K, PHE265A, PHE265K, PHE273A, PHE273K, PHE286A, PHE349A, PHE350A, PHE355A, PHE359A, PHE360A, PHE441K, PHE8K, PRO135A, PRO177A, PRO19K, PRO201K, PRO275A, PRO282A, PRO335K, PRO402A, PRO402K, PRO435K, SER16K, SER198K, SER284A, SER324A, SER339K, SER401K, SER426A, SER447K, SER448K, THR175A, THR199K, THR243A, THR252A, THR252K, THR279A, THR354A, THR399A, THR407K, THR445K, TRP197K, TYR233A, TYR259A, TYR259K, TYR300A, TYR318A, TYR344A, TYR344K, TYR369A, TYR406K, TYR446K, VAL10K, VAL14K, VAL15K, VAL23K, VAL240A, VAL281A, VAL308K, VAL315A, VAL322A, VAL329K, VAL340K, VAL405K, VAL427A, VAL7K
• A-L: ARG130A, ARG130L, ASP131L, THR129A
• B-C: ALA176C, ALA195B, ALA253C, ALA256B, ALA256C, ALA280C, ALA331B, ALA332B, ALA334B, ALA372C, ALA404B, ARG168C, ARG216C, ARG254C, ARG270B, ARG270C, ARG271C, ARG323C, ARG357C, ARG358C, ARG361C, ARG400B, ARG400C, ARG408C, ARG415B, ARG423C, ASN11B, ASN12B, ASN164C, ASN196B, ASN250C, ASN264B, ASN310B, ASN326C, ASN412B, ASN430C, ASP24B, ASP362C, CYS194B, CYS317C, CYS333B, GLN13B, GLN156B, GLN171C, GLN248C, GLN25B, GLN277C, GLN321C, GLN432C, GLN79C, GLU174C, GLU20B, GLU218C, GLU255B, GLU255C, GLU266B, GLU266C, GLU267B, GLU267C, GLU268B, GLU268C, GLU274C, GLU278C, GLU27B, GLU337B, GLU347C, GLU348C, GLU356C, GLU365C, GLU373C, GLU403B, GLU440B, GLU82C, GLY155B, GLY244C, GLY276C, GLY296B, GLY316C, GLY320C, GLY342B, GLY343B, GLY346C, GLY351C, GLY353C, GLY413B, GLY414B, HIS219C, HIS262B, HIS26B, HIS283C, HIS307B, HIS336B, HIS431C, ILE172C, ILE200B, ILE21B, ILE22B, ILE246C, ILE249C, ILE257B, ILE257C, ILE269B, ILE269C, ILE287C, ILE330B, ILE409B, ILE421B, ILE6B, LEU17B, LEU220C, LEU239C, LEU251C, LEU258B, LEU258C, LEU311B, LEU325C, LEU341B, LEU345C, LEU416B, LYS180C, LYS18B, LYS247C, LYS263B, LYS263C, LYS297B, LYS352C, LYS417B, LYS417C, LYS444B, LYS5B, LYS9B, MET272C, MET319C, MET338B, MET410B, PHE178C, PHE242C, PHE245C, PHE260B, PHE260C, PHE261B, PHE265B, PHE265C, PHE273B, PHE273C, PHE286C, PHE314B, PHE349C, PHE350C, PHE355C, PHE359C, PHE360C, PHE441B, PHE8B, PRO177C, PRO19B, PRO201B, PRO275C, PRO282C, PRO335B, PRO402B, SER154B, SER16B, SER198B, SER284C, SER324C, SER339B, SER401B, SER426C, SER447B, SER448B, THR175C, THR199B, THR243C, THR252B, THR252C, THR279C, THR354C, THR399C, THR407B, THR445B, TRP197B, TYR233C, TYR259B, TYR259C, TYR300C, TYR30C, TYR318C, TYR344B, TYR344C, TYR369C, TYR406B, TYR446B, VAL10B, VAL15B, VAL179C, VAL23B, VAL240C, VAL281C, VAL308B, VAL322C, VAL329B, VAL340B, VAL405B, VAL427C, VAL7B
• B-D: ARG358D, ARG361D, ASN11B, ASN12B, ASP362D, GLN13B, GLN367D, GLU363D, GLU365D, GLU370D, ILE6B, LEU17B, LEU366D, LYS18B, LYS364D, LYS5B, LYS9B, PHE359D, PHE360D, PHE8B, SER16B, VAL10B, VAL14B, VAL15B, VAL7B
• B-K: ARG358B, ARG361B, ASN11K, ASN12K, ASP362B, GLN13K, GLN367B, GLU363B, GLU365B, GLU370B, ILE6K, LEU17K, LEU366B, LYS18K, LYS364B, LYS5K, LYS9K, PHE359B, PHE360B, PHE8K, SER16K, VAL10K, VAL14K, VAL15K, VAL7K
• C-D: ALA176D, ALA195C, ALA253D, ALA256C, ALA256D, ALA280D, ALA331C, ALA332C, ALA334C, ALA404C, ALA63C, ARG168D, ARG216D, ARG254D, ARG270C, ARG270D, ARG271D, ARG323D, ARG357D, ARG358D, ARG361D, ARG400C, ARG400D, ARG408D, ARG415C, ARG422D, ARG423D, ASN11C, ASN12C, ASN164D, ASN196C, ASN202C, ASN250D, ASN264C, ASN326D, ASN412C, ASN430D, ASN436C, ASN443C, ASP24C, ASP362D, CYS317D, CYS333C, GLN13C, GLN156C, GLN171D, GLN248D, GLN25C, GLN277D, GLN321D, GLN432D, GLU174D, GLU20C, GLU218D, GLU255C, GLU255D, GLU266C, GLU266D, GLU267C, GLU267D, GLU268C, GLU274D, GLU278D, GLU337C, GLU347D, GLU348D, GLU356D, GLU365D, GLU398D, GLU403C, GLU440C, GLY155C, GLY244D, GLY276D, GLY296C, GLY316D, GLY320D, GLY342C, GLY343C, GLY346D, GLY351D, GLY353D, GLY413C, GLY414C, HIS184D, HIS219D, HIS262C, HIS26C, HIS283D, HIS307C, HIS336C, HIS431D, ILE172D, ILE200C, ILE21C, ILE22C, ILE246D, ILE249D, ILE257C, ILE257D, ILE269C, ILE269D, ILE287D, ILE330C, ILE409C, ILE421C, ILE6C, LEU17C, LEU239D, LEU251D, LEU258C, LEU258D, LEU311C, LEU325D, LEU341C, LEU345D, LEU416C, LEU442C, LYS162C, LYS180D, LYS18C, LYS247D, LYS263C, LYS263D, LYS297C, LYS352D, LYS417C, LYS417D, LYS444C, LYS5C, LYS64C, LYS9C, MET272D, MET319D, MET338C, MET410C, MET411C, PHE178D, PHE242D, PHE260C, PHE261C, PHE265C, PHE265D, PHE273C, PHE273D, PHE286D, PHE349D, PHE350D, PHE355D, PHE359D, PHE360D, PHE441C, PHE8C, PRO135D, PRO177D, PRO19C, PRO201C, PRO275D, PRO282D, PRO335C, PRO402C, PRO435C, SER154C, SER16C, SER198C, SER284D, SER324D, SER339C, SER401C, SER426D, SER428D, SER429D, SER447C, SER448C, SER61C, THR175D, THR199C, THR243D, THR252D, THR279D, THR354D, THR399D, THR407C, THR445C, TRP197C, TYR233D, TYR259C, TYR300D, TYR318D, TYR344C, TYR344D, TYR369D, TYR406C, TYR446C, VAL10C, VAL14C, VAL15C, VAL179D, VAL23C, VAL240D, VAL281D, VAL308C, VAL315D, VAL322D, VAL329C, VAL340C, VAL405C, VAL405D, VAL427D, VAL7C
• C-E: ARG357E, ARG358E, ARG361E, ASN11C, ASN12C, ASP362E, GLN13C, GLN367E, GLU363E, GLU365E, GLU370E, ILE6C, LEU17C, LEU366E, LYS18C, LYS364E, LYS5C, LYS9C, PHE359E, PHE360E, PHE8C, SER16C, VAL10C, VAL14C, VAL15C, VAL7C
• C-T: LEU122C, MET126T
• D-E: ALA176E, ALA195D, ALA253E, ALA256D, ALA256E, ALA280E, ALA331D, ALA332D, ALA334D, ALA404D, ARG216E, ARG254E, ARG270D, ARG270E, ARG271E, ARG323E, ARG357E, ARG358E, ARG361E, ARG400D, ARG400E, ARG408E, ARG415D, ARG422E, ARG423E, ASN11D, ASN12D, ASN164E, ASN196D, ASN250E, ASN264D, ASN326E, ASN412D, ASN430E, ASN436D, ASN443D, ASP24D, ASP362E, CYS317E, CYS333D, GLN13D, GLN156D, GLN171E, GLN248E, GLN25D, GLN277E, GLN321E, GLN432E, GLU174E, GLU20D, GLU218E, GLU255D, GLU255E, GLU266D, GLU266E, GLU267D, GLU267E, GLU268D, GLU268E, GLU274E, GLU278E, GLU337D, GLU347E, GLU348E, GLU356E, GLU365E, GLU398E, GLU403D, GLU440D, GLY244E, GLY276E, GLY296D, GLY316E, GLY320E, GLY342D, GLY343D, GLY346E, GLY351E, GLY353E, GLY413D, GLY414D, HIS184E, HIS219E, HIS262D, HIS26D, HIS283E, HIS307D, HIS336D, HIS431E, ILE172E, ILE200D, ILE21D, ILE22D, ILE246E, ILE249E, ILE257D, ILE257E, ILE269D, ILE269E, ILE287E, ILE330D, ILE409D, ILE421D, ILE6D, LEU17D, LEU239E, LEU251E, LEU258D, LEU258E, LEU311D, LEU325E, LEU341D, LEU345D, LEU345E, LEU416D, LYS162D, LYS180E, LYS18D, LYS247E, LYS263D, LYS263E, LYS297D, LYS352E, LYS417D, LYS417E, LYS444D, LYS64D, LYS9D, MET272E, MET319E, MET338D, MET410D, MET411D, PHE178E, PHE242E, PHE245E, PHE260D, PHE261D, PHE265D, PHE265E, PHE273D, PHE273E, PHE286E, PHE349E, PHE350E, PHE355E, PHE359E, PHE360E, PHE441D, PHE8D, PRO135E, PRO177E, PRO19D, PRO201D, PRO275E, PRO282E, PRO335D, PRO402D, PRO402E, PRO435D, SER16D, SER198D, SER284E, SER324E, SER339D, SER401D, SER426E, SER447D, SER448D, THR175E, THR199D, THR243E, THR252E, THR279E, THR354E, THR399E, THR407D, THR445D, TRP197D, TYR233E, TYR259D, TYR259E, TYR300E, TYR30E, TYR318E, TYR344D, TYR344E, TYR369E, TYR406D, TYR446D, VAL10D, VAL14D, VAL15D, VAL23D, VAL240E, VAL281E, VAL308D, VAL322E, VAL329D, VAL340D, VAL405D, VAL427E, VAL7D
• D-F: ARG357F, ARG358F, ARG361F, ASN11D, ASN12D, ASP362F, GLN13D, GLN367F, GLU20D, GLU363F, GLU365F, GLU370F, ILE6D, LEU17D, LEU366F, LYS18D, LYS364F, LYS9D, PHE359F, PHE360F, PHE8D, SER16D, VAL10D, VAL14D, VAL15D, VAL7D
• E-F: ALA176F, ALA195E, ALA223F, ALA253F, ALA256E, ALA256F, ALA280F, ALA331E, ALA332E, ALA334E, ALA404E, ALA62E, ALA63E, ARG168F, ARG216F, ARG254E, ARG254F, ARG270E, ARG270F, ARG271F, ARG357F, ARG358F, ARG361F, ARG400E, ARG400F, ARG408F, ARG415E, ARG422F, ARG423F, ASN11E, ASN12E, ASN164F, ASN196E, ASN250F, ASN264E, ASN326F, ASN412E, ASN430F, ASN436E, ASP24E, ASP362F, CYS194E, CYS317F, CYS333E, GLN13E, GLN156E, GLN171F, GLN248F, GLN25E, GLN277F, GLN321F, GLN432F, GLN79F, GLU174F, GLU20E, GLU218F, GLU255E, GLU255F, GLU266E, GLU266F, GLU267E, GLU267F, GLU268E, GLU274F, GLU278F, GLU27E, GLU337E, GLU347F, GLU348F, GLU356F, GLU365F, GLU373F, GLU403E, GLU440E, GLU82F, GLY155E, GLY244F, GLY276F, GLY316F, GLY320F, GLY342E, GLY343E, GLY346F, GLY351F, GLY353F, GLY413E, GLY414E, HIS184F, HIS219F, HIS262E, HIS26E, HIS283F, HIS307E, HIS336E, HIS431F, ILE172F, ILE200E, ILE21E, ILE22E, ILE246F, ILE249F, ILE257E, ILE257F, ILE269E, ILE269F, ILE287F, ILE330E, ILE409E, ILE41E, ILE421E, ILE6E, LEU17E, LEU220F, LEU239F, LEU251F, LEU258E, LEU258F, LEU311E, LEU325F, LEU341E, LEU345F, LEU366F, LEU416E, LYS162E, LYS180F, LYS18E, LYS247F, LYS263E, LYS263F, LYS297E, LYS352F, LYS417E, LYS444E, LYS9E, MET272F, MET319F, MET338E, MET410E, PHE178F, PHE242F, PHE245F, PHE260E, PHE260F, PHE261E, PHE265E, PHE265F, PHE273E, PHE273F, PHE286F, PHE349F, PHE350F, PHE355F, PHE359F, PHE360F, PHE441E, PHE80F, PHE8E, PRO177F, PRO19E, PRO201E, PRO275F, PRO282F, PRO335E, PRO402E, PRO402F, PRO435E, SER151E, SER154E, SER16E, SER198E, SER284F, SER324F, SER339E, SER401E, SER426F, SER429F, SER447E, SER448E, SER61E, THR175F, THR199E, THR243F, THR252F, THR279F, THR354F, THR399F, THR407E, THR445E, TRP197E, TYR221F, TYR233F, TYR259E, TYR259F, TYR300F, TYR318F, TYR344E, TYR344F, TYR369F, TYR406E, TYR446E, VAL10E, VAL179F, VAL23E, VAL240F, VAL281F, VAL308E, VAL322F, VAL329E, VAL340E, VAL405E, VAL427F, VAL7E
• E-G: ARG357G, ARG358G, ARG361G, ASN11E, ASN12E, ASP362G, GLN13E, GLN367G, GLU20E, GLU363G, GLU365G, GLU370G, ILE6E, LEU17E, LEU366G, LYS18E, LYS364G, LYS9E, PHE359G, PHE360G, PHE8E, SER16E, TYR369G, VAL10E, VAL14E, VAL15E, VAL7E
• F-G: ALA176G, ALA195F, ALA253G, ALA256F, ALA256G, ALA280G, ALA331F, ALA332F, ALA334F, ALA404F, ALA63F, ARG168G, ARG216G, ARG254G, ARG270F, ARG270G, ARG271G, ARG323G, ARG357G, ARG358G, ARG361G, ARG400F, ARG400G, ARG408G, ARG415F, ARG422G, ARG423G, ASN11F, ASN12F, ASN164G, ASN196F, ASN202F, ASN250G, ASN264F, ASN326G, ASN412F, ASN430G, ASN436F, ASN443F, ASP24F, ASP362G, CYS317G, CYS333F, GLN13F, GLN156F, GLN171G, GLN248G, GLN25F, GLN277G, GLN321G, GLN432G, GLU174G, GLU20F, GLU218G, GLU255F, GLU255G, GLU266F, GLU266G, GLU267F, GLU267G, GLU268F, GLU274G, GLU278G, GLU337F, GLU347G, GLU348G, GLU356G, GLU365G, GLU403F, GLU440F, GLY155F, GLY244G, GLY276G, GLY316G, GLY320G, GLY342F, GLY343F, GLY346G, GLY351G, GLY353G, GLY413F, GLY414F, HIS184G, HIS219G, HIS262F, HIS26F, HIS283G, HIS307F, HIS336F, HIS431G, ILE172G, ILE200F, ILE21F, ILE22F, ILE246G, ILE249G, ILE257F, ILE257G, ILE269F, ILE269G, ILE287G, ILE330F, ILE409F, ILE421F, ILE6F, LEU17F, LEU239G, LEU251G, LEU258F, LEU258G, LEU311F, LEU325G, LEU341F, LEU345F, LEU345G, LEU416F, LEU442F, LYS162F, LYS180G, LYS18F, LYS247G, LYS263F, LYS263G, LYS297F, LYS352G, LYS417F, LYS444F, LYS64F, LYS9F, MET272G, MET319G, MET338F, MET410F, PHE178G, PHE242G, PHE260F, PHE261F, PHE265F, PHE265G, PHE273F, PHE273G, PHE286G, PHE349G, PHE350G, PHE355G, PHE359G, PHE360G, PHE441F, PHE8F, PRO135G, PRO177G, PRO19F, PRO201F, PRO275G, PRO282G, PRO335F, PRO402F, PRO402G, PRO435F, SER154F, SER16F, SER198F, SER284G, SER324G, SER339F, SER401F, SER426G, SER428G, SER429G, SER447F, SER448F, THR175G, THR199F, THR243G, THR252G, THR279G, THR354G, THR399G, THR407F, THR445F, TRP197F, TYR233G, TYR259F, TYR300G, TYR318G, TYR344F, TYR344G, TYR369G, TYR406F, TYR424F, TYR446F, VAL10F, VAL15F, VAL179G, VAL23F, VAL240G, VAL281G, VAL308F, VAL322G, VAL340F, VAL405F, VAL405G, VAL427G, VAL7F
• F-H: ARG357H, ARG358H, ARG361H, ASN11F, ASN12F, ASP362H, GLN13F, GLN367H, GLU363H, GLU365H, GLU370H, ILE6F, LEU17F, LEU366H, LYS18F, LYS364H, LYS9F, PHE359H, PHE360H, PHE8F, SER16F, VAL10F, VAL14F, VAL15F, VAL7F
• F-Q: LEU122F, MET126Q
• F-R: ARG130F, ARG130R
• G-H: ALA176H, ALA195G, ALA253H, ALA256G, ALA256H, ALA280H, ALA331G, ALA332G, ALA334G, ALA404G, ALA63G, ARG168H, ARG216H, ARG254H, ARG270G, ARG270H, ARG271G, ARG271H, ARG323H, ARG357H, ARG358H, ARG361H, ARG400G, ARG400H, ARG408H, ARG415G, ARG422H, ARG423H, ASN11G, ASN12G, ASN164H, ASN196G, ASN250H, ASN264G, ASN326H, ASN412G, ASN430H, ASN436G, ASN443G, ASP24G, ASP362H, CYS317H, CYS333G, GLN13G, GLN156G, GLN171H, GLN248H, GLN25G, GLN277H, GLN321H, GLN432H, GLU174H, GLU20G, GLU218H, GLU255G, GLU255H, GLU266G, GLU266H, GLU267G, GLU267H, GLU268G, GLU274H, GLU278H, GLU337G, GLU347H, GLU348H, GLU356H, GLU365H, GLU398H, GLU403G, GLU440G, GLY155G, GLY244H, GLY276H, GLY316H, GLY320H, GLY342G, GLY343G, GLY346H, GLY351H, GLY353H, GLY413G, GLY414G, HIS184H, HIS219H, HIS262G, HIS26G, HIS283H, HIS307G, HIS336G, HIS431H, ILE172H, ILE200G, ILE21G, ILE22G, ILE246H, ILE249H, ILE257G, ILE257H, ILE269G, ILE269H, ILE287H, ILE330G, ILE409G, ILE421G, ILE6G, LEU17G, LEU239H, LEU251H, LEU258G, LEU258H, LEU311G, LEU325H, LEU341G, LEU345H, LEU416G, LEU442G, LYS180H, LYS18G, LYS247H, LYS263G, LYS263H, LYS297G, LYS352H, LYS417G, LYS417H, LYS444G, LYS64G, LYS9G, MET272H, MET319H, MET338G, MET410G, PHE178H, PHE242H, PHE260G, PHE261G, PHE265G, PHE265H, PHE273G, PHE273H, PHE286H, PHE349H, PHE350H, PHE355H, PHE359H, PHE360H, PHE441G, PHE8G, PRO135H, PRO177H, PRO19G, PRO201G, PRO275H, PRO282H, PRO335G, PRO402G, PRO402H, PRO435G, SER154G, SER16G, SER198G, SER284H, SER324H, SER339G, SER401G, SER426H, SER447G, SER448G, THR175H, THR199G, THR243H, THR252H, THR279H, THR354H, THR399H, THR407G, THR445G, TRP197G, TYR221H, TYR233H, TYR259G, TYR259H, TYR300H, TYR318H, TYR344G, TYR344H, TYR369H, TYR406G, TYR446G, VAL10G, VAL14G, VAL15G, VAL179H, VAL23G, VAL240H, VAL281H, VAL308G, VAL322H, VAL329G, VAL340G, VAL405G, VAL405H, VAL427H, VAL7G
• G-I: ARG357I, ARG358I, ARG361I, ASN11G, ASN12G, ASP362I, GLN13G, GLN367I, GLU20G, GLU363I, GLU365I, GLU370I, ILE6G, LEU17G, LEU366I, LYS18G, LYS364I, LYS9G, PHE359I, PHE360I, PHE8G, SER16G, VAL10G, VAL14G, VAL15G, VAL7G
• G-P: ALA121G, ALA121P, ALA52G, ALA52P, ALA63G, ARG130G, ARG130P, ASN119G, ASN119P, GLU127G, GLU127P, GLY124G, GLY124P, GLY125G, GLY125P, GLY59P, LEU122G, LEU122P, LEU128G, LEU128P, LEU49G, LEU49P, MET126G, MET126P, SER61P, THR123G, THR123P, THR129G, THR129P, TRP120G, TRP120P, TYR53G, TYR53P, VAL56G, VAL56P
• H-I: ALA176I, ALA195H, ALA223I, ALA253I, ALA256H, ALA256I, ALA280I, ALA331H, ALA332H, ALA334H, ALA372I, ALA404H, ARG168I, ARG216I, ARG254I, ARG270H, ARG270I, ARG271I, ARG323I, ARG357I, ARG358I, ARG361I, ARG400H, ARG400I, ARG408I, ARG415H, ARG422I, ARG423I, ASN11H, ASN12H, ASN164I, ASN196H, ASN250I, ASN264H, ASN326I, ASN412H, ASN430I, ASN436H, ASN443H, ASP24H, ASP362I, CYS317I, CYS333H, GLN13H, GLN156H, GLN171I, GLN248I, GLN25H, GLN277I, GLN321I, GLN432I, GLU174I, GLU20H, GLU218I, GLU255H, GLU255I, GLU266H, GLU266I, GLU267H, GLU267I, GLU268H, GLU268I, GLU274I, GLU278I, GLU27H, GLU337H, GLU347I, GLU348I, GLU356I, GLU365I, GLU373I, GLU403H, GLU440H, GLU82I, GLY155H, GLY244I, GLY276I, GLY296H, GLY316I, GLY320I, GLY342H, GLY343H, GLY346I, GLY351I, GLY353I, GLY413H, GLY414H, HIS184I, HIS219I, HIS262H, HIS26H, HIS283I, HIS307H, HIS336H, HIS431I, ILE172I, ILE200H, ILE21H, ILE22H, ILE246I, ILE249I, ILE257H, ILE257I, ILE269H, ILE269I, ILE287I, ILE330H, ILE409H, ILE421H, ILE6H, LEU17H, LEU220I, LEU239I, LEU251I, LEU258H, LEU258I, LEU311H, LEU325I, LEU341H, LEU345I, LEU416H, LYS162H, LYS180I, LYS18H, LYS247I, LYS263H, LYS263I, LYS297H, LYS352I, LYS417H, LYS444H, LYS5H, LYS64H, LYS9H, MET272I, MET319I, MET338H, MET410H, PHE178I, PHE242I, PHE245I, PHE260H, PHE260I, PHE261H, PHE265H, PHE265I, PHE273H, PHE273I, PHE286I, PHE349I, PHE350I, PHE355I, PHE359I, PHE360I, PHE441H, PHE8H, PRO135I, PRO177I, PRO19H, PRO201H, PRO275I, PRO282I, PRO335H, PRO402H, PRO402I, PRO435H, SER16H, SER198H, SER284I, SER324I, SER339H, SER401H, SER426I, SER428I, SER447H, SER448H, THR175I, THR199H, THR243I, THR252H, THR252I, THR279I, THR354I, THR399I, THR407H, THR445H, TRP197H, TYR221I, TYR233I, TYR259H, TYR259I, TYR300I, TYR318I, TYR344H, TYR369I, TYR406H, TYR446H, VAL10H, VAL23H, VAL240I, VAL281I, VAL308H, VAL315I, VAL322I, VAL329H, VAL340H, VAL405H, VAL405I, VAL427I, VAL7H
• H-J: ARG358J, ARG361J, ASN11H, ASN12H, ASP362J, GLN13H, GLN367J, GLU20H, GLU363J, GLU365J, GLU370J, ILE6H, LEU17H, LEU366J, LYS18H, LYS364J, LYS5H, LYS9H, PHE359J, PHE360J, PHE8H, SER16H, VAL10H, VAL14H, VAL15H, VAL7H
• H-O: ALA121H, ALA121O, ALA52H, ALA52O, ARG130H, ARG130O, ASN119H, ASN119O, GLU127H, GLU127O, GLY124H, GLY124O, GLY125H, GLY125O, LEU122H, LEU122O, LEU128H, LEU128O, LEU49H, LEU49O, MET126H, MET126O, SER61H, THR123H, THR123O, THR129H, THR129O, TRP120H, TRP120O, TYR53H, TYR53O, VAL56H, VAL56O
• H-P: ARG130H, ARG130P, THR129H
• I-J: ALA176J, ALA195I, ALA223J, ALA253J, ALA256I, ALA256J, ALA280J, ALA331I, ALA332I, ALA334I, ALA404I, ALA62I, ALA63I, ARG216J, ARG254J, ARG270I, ARG270J, ARG271J, ARG323J, ARG357J, ARG358J, ARG361J, ARG400I, ARG400J, ARG408J, ARG415I, ARG422J, ARG423J, ASN11I, ASN12I, ASN164J, ASN196I, ASN250J, ASN264I, ASN412I, ASN430J, ASN436I, ASP24I, ASP362J, CYS333I, GLN13I, GLN156I, GLN171J, GLN248J, GLN25I, GLN277J, GLN321J, GLN432J, GLU174J, GLU20I, GLU218J, GLU255I, GLU255J, GLU266I, GLU266J, GLU267I, GLU267J, GLU268I, GLU268J, GLU274J, GLU278J, GLU27I, GLU337I, GLU347J, GLU348J, GLU356J, GLU365J, GLU373J, GLU398J, GLU403I, GLU440I, GLU82J, GLY244J, GLY276J, GLY296I, GLY316J, GLY320J, GLY342I, GLY343I, GLY346J, GLY351J, GLY353J, GLY413I, GLY414I, HIS184J, HIS219J, HIS262I, HIS262J, HIS26I, HIS283J, HIS307I, HIS336I, HIS431J, ILE172J, ILE200I, ILE21I, ILE22I, ILE246J, ILE249J, ILE257I, ILE257J, ILE269I, ILE269J, ILE287J, ILE330I, ILE409I, ILE41I, ILE421I, ILE6I, LEU17I, LEU220J, LEU239J, LEU251J, LEU258I, LEU258J, LEU311I, LEU325J, LEU341I, LEU345J, LEU416I, LYS180J, LYS18I, LYS247J, LYS263I, LYS263J, LYS297I, LYS29I, LYS352J, LYS417I, LYS444I, LYS5J, LYS64I, LYS9I, MET272J, MET319J, MET338I, MET410I, PHE178J, PHE242J, PHE245J, PHE260I, PHE260J, PHE261I, PHE265I, PHE265J, PHE273I, PHE273J, PHE286J, PHE349J, PHE350J, PHE355J, PHE359J, PHE360J, PHE441I, PHE80J, PHE8I, PRO135J, PRO177J, PRO19I, PRO201I, PRO275J, PRO282J, PRO335I, PRO402I, PRO402J, PRO435I, SER16I, SER198I, SER284J, SER324J, SER339I, SER401I, SER426J, SER447I, SER448I, THR175J, THR199I, THR243J, THR252I, THR252J, THR279J, THR354J, THR399J, THR407I, THR445I, TRP197I, TYR233J, TYR259I, TYR259J, TYR300J, TYR30J, TYR318J, TYR344I, TYR344J, TYR369J, TYR406I, TYR446I, VAL10I, VAL15I, VAL23I, VAL240J, VAL281J, VAL308I, VAL322J, VAL340I, VAL405I, VAL427J, VAL7I
• I-K: ARG357K, ARG358K, ARG361K, ASN11I, ASN12I, ASP362K, GLN13I, GLN367K, GLU20I, GLU363K, GLU365K, GLU370K, ILE6I, LEU17I, LEU366K, LYS18I, LYS364K, LYS9I, PHE359K, PHE360K, PHE8I, SER16I, TYR369K, VAL10I, VAL14I, VAL15I, VAL7I
• I-N: ALA121I, ALA121N, ALA52I, ALA52N, ALA63N, ARG130I, ARG130N, ASN119I, ASN119N, ASN50N, ASP131I, ASP131N, ASP48N, GLU117N, GLU127I, GLU127N, GLY118N, GLY124I, GLY124N, GLY125I, GLY125N, GLY59I, LEU122I, LEU122N, LEU128I, LEU128N, LEU49I, LEU49N, LEU65N, MET126I, MET126N, PRO47N, SER58I, SER61I, THR123I, THR123N, THR129I, THR129N, TRP120I, TRP120N, TYR53I, TYR53N, VAL56I, VAL56N
• I-O: ARG130I, ARG130O, THR129I, THR129O
• J-K: ALA176K, ALA195J, ALA253K, ALA256J, ALA256K, ALA280K, ALA331J, ALA332J, ALA334J, ALA404J, ARG168K, ARG216K, ARG254K, ARG270J, ARG270K, ARG271K, ARG323K, ARG357K, ARG358K, ARG361K, ARG400J, ARG400K, ARG408K, ARG415J, ARG422K, ARG423K, ASN11J, ASN12J, ASN164K, ASN196J, ASN250K, ASN264J, ASN326K, ASN412J, ASN430K, ASN436J, ASN443J, ASP24J, ASP362K, CYS317K, CYS333J, GLN13J, GLN156J, GLN171K, GLN248K, GLN25J, GLN277K, GLN321K, GLN432K, GLU174K, GLU20J, GLU218K, GLU255J, GLU255K, GLU266J, GLU266K, GLU267J, GLU267K, GLU268J, GLU268K, GLU274K, GLU278K, GLU337J, GLU347K, GLU348K, GLU356K, GLU365K, GLU403J, GLU440J, GLU82K, GLY155J, GLY244K, GLY276K, GLY296J, GLY316K, GLY320K, GLY342J, GLY343J, GLY346K, GLY351K, GLY353K, GLY413J, GLY414J, HIS184K, HIS219K, HIS262J, HIS26J, HIS283K, HIS307J, HIS336J, HIS420J, HIS420K, HIS431K, ILE172K, ILE200J, ILE21J, ILE22J, ILE246K, ILE249K, ILE257J, ILE257K, ILE269J, ILE269K, ILE287K, ILE330J, ILE409J, ILE421J, ILE6J, LEU17J, LEU220K, LEU239K, LEU251K, LEU258J, LEU258K, LEU311J, LEU325K, LEU341J, LEU345K, LEU416J, LYS162J, LYS180K, LYS18J, LYS247K, LYS263J, LYS263K, LYS297J, LYS352K, LYS417J, LYS444J, LYS5J, LYS64J, LYS9J, MET272K, MET319K, MET338J, MET410J, PHE178K, PHE242K, PHE245K, PHE260J, PHE261J, PHE265J, PHE265K, PHE273J, PHE273K, PHE286K, PHE349K, PHE350K, PHE355K, PHE359K, PHE360K, PHE441J, PHE8J, PRO135K, PRO177K, PRO19J, PRO201J, PRO275K, PRO282K, PRO335J, PRO402J, PRO402K, PRO435J, SER16J, SER198J, SER284K, SER339J, SER401J, SER426K, SER447J, SER448J, THR175K, THR199J, THR243K, THR252K, THR279K, THR354K, THR399K, THR407J, THR445J, TRP197J, TYR233K, TYR259J, TYR259K, TYR300K, TYR30K, TYR318K, TYR344J, TYR344K, TYR369K, TYR406J, TYR424J, TYR446J, VAL10J, VAL15J, VAL23J, VAL240K, VAL281K, VAL308J, VAL322K, VAL329J, VAL340J, VAL427K, VAL7J
• J-M: ALA121J, ALA121M, ALA52J, ALA52M, ARG130J, ARG130M, ASN119J, ASN119M, ASN50M, ASP131M, GLU127J, GLU127M, GLY124J, GLY124M, GLY125J, GLY125M, GLY59J, LEU122J, LEU122M, LEU128J, LEU128M, LEU49J, LEU49M, LEU65M, MET126J, MET126M, SER58J, SER61J, SER61M, THR123J, THR123M, THR129J, THR129M, TRP120J, TRP120M, TYR53J, TYR53M, VAL56J, VAL56M
• J-N: ARG130J, ARG130N, GLU127J, LEU128J, THR129J
• K-L: ALA121K, ALA121L, ALA52K, ALA52L, ALA63L, ARG130K, ARG130L, ASN119K, ASN119L, ASN50L, ASP131L, ASP48L, GLU127K, GLU127L, GLY118L, GLY124K, GLY124L, GLY125K, GLY125L, GLY59K, LEU122K, LEU122L, LEU128K, LEU128L, LEU49K, LEU49L, LEU65L, MET126K, MET126L, PRO47L, SER55K, SER58K, SER61K, SER61L, THR123K, THR123L, THR129K, THR129L, TRP120K, TRP120L, TYR53K, TYR53L, VAL56K, VAL56L
• K-M: ARG130K, ARG130M, THR129K, THR129M
• L-M: ALA176M, ALA195L, ALA253M, ALA256L, ALA256M, ALA280M, ALA331L, ALA332L, ALA334L, ALA372M, ALA404L, ALA63L, ARG168M, ARG216M, ARG254M, ARG270L, ARG270M, ARG271M, ARG323M, ARG357M, ARG358M, ARG361M, ARG400L, ARG400M, ARG408M, ARG415L, ARG422M, ARG423M, ASN11L, ASN12L, ASN164M, ASN196L, ASN250M, ASN264L, ASN326M, ASN412L, ASN430M, ASN436L, ASN443L, ASP24L, ASP362M, CYS317M, CYS333L, GLN13L, GLN156L, GLN171M, GLN248M, GLN25L, GLN277M, GLN321M, GLN432M, GLU174M, GLU20L, GLU218M, GLU255L, GLU255M, GLU266L, GLU266M, GLU267L, GLU267M, GLU268L, GLU268M, GLU274M, GLU278M, GLU337L, GLU347M, GLU348M, GLU356M, GLU365M, GLU398M, GLU403L, GLU440L, GLY155L, GLY244M, GLY276M, GLY316M, GLY320M, GLY342L, GLY343L, GLY346M, GLY351M, GLY353M, GLY413L, GLY414L, HIS184M, HIS219M, HIS262L, HIS283M, HIS307L, HIS336L, HIS420L, HIS431M, ILE172M, ILE200L, ILE21L, ILE22L, ILE246M, ILE249M, ILE257L, ILE257M, ILE269L, ILE269M, ILE287M, ILE330L, ILE409L, ILE421L, ILE6L, LEU17L, LEU239M, LEU251M, LEU258L, LEU258M, LEU311L, LEU325M, LEU341L, LEU345M, LEU366M, LEU416L, LEU442L, LYS162L, LYS180M, LYS18L, LYS247M, LYS263L, LYS263M, LYS297L, LYS352M, LYS417L, LYS444L, LYS5L, LYS64L, LYS9L, MET272M, MET319M, MET338L, MET410L, MET411L, MET60L, PHE178M, PHE242M, PHE260L, PHE261L, PHE265L, PHE265M, PHE273L, PHE273M, PHE286M, PHE349M, PHE350M, PHE355M, PHE359M, PHE360M, PHE441L, PHE8L, PRO135M, PRO177M, PRO19L, PRO201L, PRO275M, PRO282M, PRO335L, PRO402L, PRO402M, PRO435L, SER154L, SER16L, SER198L, SER284M, SER339L, SER401L, SER426M, SER428M, SER447L, SER448L, SER61L, THR175M, THR199L, THR243M, THR252M, THR279M, THR354M, THR399M, THR407L, THR445L, TRP197L, TYR221M, TYR233M, TYR259L, TYR259M, TYR300M, TYR318M, TYR344L, TYR344M, TYR369M, TYR406L, TYR446L, VAL10L, VAL14L, VAL15L, VAL179M, VAL23L, VAL240M, VAL281M, VAL308L, VAL322M, VAL329L, VAL340L, VAL405L, VAL405M, VAL427M, VAL7L
• L-N: ARG357N, ARG358N, ARG361N, ASN11L, ASN12L, ASP362N, GLN13L, GLN367N, GLU20L, GLU363N, GLU365N, GLU370N, ILE6L, LEU17L, LEU366N, LYS18L, LYS364N, LYS5L, LYS9L, PHE359N, PHE360N, PHE8L, SER16L, VAL10L, VAL14L, VAL15L, VAL7L
• L-U: ASP362L, GLU363L, LYS364L, LYS5U, LYS9U, PHE360L
• L-V: ARG254L, ARG270L, ARG357L, ARG358L, ARG361L, ARG400L, ARG415V, ASP24V, GLU20V, GLU255L, GLU255V, GLU266V, GLU274L, GLU337V, GLU356L, GLU365L, GLU398L, GLU403V, GLY353L, GLY414V, HIS262V, HIS431L, LYS18V, LYS247L, LYS263V, LYS352L, LYS444V, THR354L
• M-N: ALA176N, ALA195M, ALA223N, ALA253N, ALA256M, ALA256N, ALA280N, ALA331M, ALA332M, ALA334M, ALA404M, ALA62M, ALA63M, ARG168N, ARG216N, ARG254N, ARG270M, ARG270N, ARG271N, ARG290M, ARG323N, ARG357N, ARG358N, ARG361N, ARG400M, ARG400N, ARG408N, ARG415M, ARG422N, ARG423N, ASN11M, ASN12M, ASN164N, ASN196M, ASN250N, ASN264M, ASN310M, ASN326N, ASN412M, ASN430N, ASN436M, ASN443M, ASP24M, ASP362N, CYS194M, CYS236N, CYS317N, CYS333M, GLN13M, GLN156M, GLN171N, GLN248N, GLN25M, GLN277N, GLN321N, GLN432N, GLN79N, GLU174N, GLU20M, GLU218N, GLU255M, GLU255N, GLU266M, GLU266N, GLU267M, GLU267N, GLU268M, GLU268N, GLU274N, GLU278N, GLU27M, GLU337M, GLU347N, GLU348N, GLU356N, GLU365N, GLU373N, GLU403M, GLU440M, GLU82N, GLY155M, GLY244N, GLY276N, GLY296M, GLY316N, GLY320N, GLY342M, GLY343M, GLY346N, GLY351N, GLY353N, GLY413M, GLY414M, GLY83N, HIS184N, HIS219N, HIS262M, HIS262N, HIS26M, HIS283N, HIS307M, HIS336M, HIS431N, ILE172N, ILE200M, ILE21M, ILE22M, ILE246N, ILE249N, ILE257M, ILE257N, ILE269M, ILE269N, ILE287N, ILE330M, ILE409M, ILE41M, ILE421M, ILE6M, LEU17M, LEU220N, LEU239N, LEU251N, LEU258M, LEU258N, LEU311M, LEU325N, LEU341M, LEU345M, LEU345N, LEU366N, LEU416M, LYS162M, LYS180N, LYS18M, LYS247N, LYS263M, LYS263N, LYS297M, LYS29M, LYS352N, LYS417M, LYS444M, LYS5M, LYS64M, LYS9M, MET272N, MET319N, MET338M, MET410M, PHE178N, PHE242N, PHE245N, PHE260M, PHE260N, PHE261M, PHE265M, PHE265N, PHE273M, PHE273N, PHE286N, PHE349N, PHE350N, PHE355N, PHE359N, PHE360N, PHE441M, PHE80N, PHE8M, PRO135N, PRO177N, PRO19M, PRO201M, PRO275N, PRO282N, PRO335M, PRO402M, PRO402N, PRO435M, SER16M, SER198M, SER215N, SER339M, SER401M, SER426N, SER447M, SER448M, SER61M, THR133N, THR175N, THR199M, THR243N, THR252M, THR252N, THR279N, THR354N, THR399N, THR407M, THR445M, TRP197M, TYR221N, TYR233N, TYR259M, TYR259N, TYR300N, TYR318N, TYR344M, TYR344N, TYR369N, TYR406M, TYR446M, VAL10M, VAL134N, VAL15M, VAL179N, VAL23M, VAL240N, VAL281N, VAL308M, VAL315N, VAL322N, VAL329M, VAL340M, VAL405M, VAL427N, VAL7M
• M-O: ARG357O, ARG358O, ARG361O, ASN11M, ASN12M, ASP362O, GLN13M, GLN367O, GLU20M, GLU363O, GLU365O, GLU370O, ILE6M, LEU17M, LEU366O, LYS18M, LYS364O, LYS5M, LYS9M, PHE359O, PHE360O, PHE8M, SER16M, TYR369O, VAL10M, VAL14M, VAL15M, VAL7M
• M-V: ASP362M, GLU363M, GLU365M, LYS364M, LYS9V, PHE360M
• N-O: ALA176O, ALA195N, ALA253O, ALA256N, ALA256O, ALA280O, ALA331N, ALA332N, ALA334N, ALA404N, ALA439O, ALA63N, ARG168O, ARG216O, ARG254O, ARG270N, ARG270O, ARG271O, ARG323O, ARG357O, ARG358O, ARG361O, ARG400O, ARG408O, ARG415N, ARG422O, ARG423O, ASN11N, ASN12N, ASN164O, ASN196N, ASN250O, ASN264N, ASN326O, ASN412N, ASN430O, ASN436N, ASN443N, ASP24N, ASP362O, CYS317O, CYS333N, GLN13N, GLN156N, GLN171O, GLN248O, GLN25N, GLN277O, GLN321O, GLN432O, GLU174O, GLU20N, GLU218O, GLU255N, GLU255O, GLU266N, GLU266O, GLU267N, GLU267O, GLU268N, GLU274O, GLU278O, GLU337N, GLU347O, GLU348O, GLU356O, GLU365O, GLU403N, GLU440N, GLY155N, GLY244O, GLY276O, GLY316O, GLY320O, GLY342N, GLY343N, GLY346O, GLY351O, GLY353O, GLY413N, GLY414N, HIS184O, HIS219O, HIS262N, HIS283O, HIS307N, HIS336N, HIS431O, ILE172O, ILE200N, ILE21N, ILE22N, ILE246O, ILE249O, ILE257N, ILE257O, ILE269N, ILE269O, ILE287O, ILE330N, ILE409N, ILE421N, ILE6N, LEU17N, LEU239O, LEU251O, LEU258N, LEU258O, LEU311N, LEU325O, LEU341N, LEU345N, LEU345O, LEU416N, LEU442N, LYS162N, LYS180O, LYS18N, LYS247O, LYS263N, LYS297N, LYS352O, LYS417N, LYS444N, LYS64N, LYS9N, MET272O, MET319O, MET338N, MET410N, PHE178O, PHE242O, PHE260N, PHE261N, PHE265N, PHE265O, PHE273N, PHE273O, PHE286O, PHE349O, PHE350O, PHE355O, PHE359O, PHE360O, PHE441N, PHE8N, PRO135O, PRO177O, PRO19N, PRO201N, PRO275O, PRO282O, PRO335N, PRO402N, PRO402O, PRO435N, SER154N, SER16N, SER198N, SER284O, SER339N, SER401N, SER426O, SER428O, SER429O, SER447N, SER448N, SER61N, THR175O, THR199N, THR243O, THR252O, THR279O, THR354O, THR399O, THR407N, THR445N, TRP197N, TYR221O, TYR233O, TYR259N, TYR300O, TYR318O, TYR344N, TYR344O, TYR369O, TYR406N, TYR446N, VAL10N, VAL15N, VAL179O, VAL23N, VAL240O, VAL281O, VAL308N, VAL315O, VAL322O, VAL329N, VAL340N, VAL427O, VAL7N
• N-P: ASP362P, GLU363P, GLU365P, LYS9N, PHE360P
• O-P: ALA176P, ALA195O, ALA253P, ALA256P, ALA280P, ALA331O, ALA332O, ALA334O, ALA63O, ARG168P, ARG216P, ARG254P, ARG270P, ARG271P, ARG357P, ARG358P, ARG361P, ARG400P, ARG415O, ASN11O, ASN12O, ASN164P, ASN196O, ASN250P, ASN264O, ASP24O, CYS333O, GLN13O, GLN156O, GLN171P, GLN248P, GLN25O, GLN277P, GLU174P, GLU20O, GLU218P, GLU255O, GLU255P, GLU266O, GLU266P, GLU267P, GLU274P, GLU278P, GLU337O, GLU356P, GLU365P, GLU403O, GLY155O, GLY244P, GLY276P, GLY296O, GLY353P, GLY414O, HIS184P, HIS219P, HIS262O, HIS26O, HIS283P, HIS307O, HIS336O, HIS431P, ILE172P, ILE200O, ILE21O, ILE22O, ILE246P, ILE249P, ILE257P, ILE269P, ILE287P, ILE330O, ILE6O, LEU17O, LEU239P, LEU251P, LEU258P, LYS162O, LYS180P, LYS18O, LYS247P, LYS263O, LYS263P, LYS297O, LYS352P, LYS444O, LYS64O, LYS9O, MET272P, MET338O, PHE178P, PHE242P, PHE261O, PHE265O, PHE265P, PHE273P, PHE286P, PHE441O, PHE8O, PRO135P, PRO177P, PRO19O, PRO201O, PRO275P, PRO282P, PRO335O, SER16O, SER198O, SER284P, THR175P, THR199O, THR243P, THR252P, THR279P, THR354P, THR445O, TRP197O, TYR233P, TYR259P, TYR300P, VAL10O, VAL15O, VAL23O, VAL240P, VAL281P, VAL7O
• O-Q: ASP362Q, GLU363Q, LYS364Q, LYS9O, PHE360Q
• P-Q: ARG254Q, ARG270Q, ARG357Q, ARG358Q, ARG361Q, ARG400Q, ARG415P, ASP24P, GLU20P, GLU255P, GLU255Q, GLU266P, GLU274Q, GLU337P, GLU347Q, GLU348Q, GLU356Q, GLU365Q, GLU403P, GLY351Q, GLY353Q, GLY414P, HIS262P, HIS431Q, LEU416P, LYS18P, LYS247Q, LYS263P, LYS352Q, LYS444P, PHE261P
• P-R: ASP362R, GLU363R, GLU365R, LYS364R, LYS9P, PHE360R
• Q-R: ARG254R, ARG270R, ARG357R, ARG358R, ARG361R, ARG415Q, ASP24Q, GLU20Q, GLU255Q, GLU255R, GLU266Q, GLU274R, GLU337Q, GLU347R, GLU356R, GLU365R, GLU403Q, GLY353R, GLY414Q, HIS262Q, HIS431R, LYS18Q, LYS247R, LYS263Q, LYS352R, LYS444Q, PHE261Q, THR354R
• Q-S: ASP362S, GLU363S, GLU365S, LYS364S, LYS9Q, PHE360S
• R-S: ARG254S, ARG270S, ARG357S, ARG358S, ARG361S, ARG415R, ARG423S, ASP24R, GLU20R, GLU255R, GLU255S, GLU266R, GLU274S, GLU337R, GLU347S, GLU356S, GLU403R, GLY353S, GLY414R, HIS262R, HIS431S, LYS18R, LYS247S, LYS263R, LYS352S, LYS444R, LYS5R, THR354S, THR445R
• R-T: ARG361T, ASP362T, GLU363T, GLU365T, LYS364T, LYS5R, LYS9R, PHE360T
• S-T: ARG254T, ARG270T, ARG357T, ARG358T, ARG361T, ARG415S, ASP24S, GLU20S, GLU255S, GLU255T, GLU266S, GLU274T, GLU337S, GLU347T, GLU356T, GLU365T, GLU403S, GLY353T, GLY414S, HIS262S, HIS431T, LYS18S, LYS247T, LYS263S, LYS352T, LYS444S, THR354T
• S-U: ASP362U, GLU363U, GLU365U, LYS364U, LYS9S, PHE360U
• T-U: ARG254U, ARG270U, ARG357U, ARG358U, ARG361U, ARG415T, ASP24T, GLU20T, GLU255T, GLU255U, GLU266T, GLU274U, GLU337T, GLU347U, GLU356U, GLU365U, GLU403T, GLY351U, GLY353U, GLY414T, HIS262T, HIS431U, LEU416T, LYS18T, LYS247U, LYS263T, LYS352U, LYS444T, THR354U
• T-V: ASP362V, GLU363V, LYS9T, PHE360V
• U-V: ARG254V, ARG270V, ARG357V, ARG358V, ARG361V, ARG400V, ARG415U, ARG423V, ASP24U, GLU20U, GLU255U, GLU255V, GLU266U, GLU274V, GLU337U, GLU347V, GLU348V, GLU356V, GLU398V, GLU403U, GLY351V, GLY353V, GLY414U, HIS262U, HIS431V, ILE6U, LEU416U, LYS18U, LYS247V, LYS263U, LYS352V, LYS444U, THR354V, THR445U