2GTL

lumbricus erythrocruorin at 3.5a resolution

• Total interactions analyzed: 105
• Total true interactions: 41
• Strongest Interaction:
  • Chains: N-O
  • Int. Res.: 126
  • Norm. En. per Res.: -3.3042
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	-3.1474	721.774	718.6266	49	4	6	4216	0	15	14
A-C	0.0	-8.7622	-49.4997	-58.2619	23	2	0	1981	2	9	12
A-D	-6.0104	19.2799	-254.463	-241.1935	117	20	3	11993	2	34	43
A-G	-24.7606	-42.6173	544.766	477.3881	62	15	4	6177	7	35	42
A-H	0.0	0.0	-0.1533	-0.1533	7	0	0	28	0	2	1
A-M	-6.7065	13.5911	-66.8079	-59.9233	40	4	0	2725	0	4	9
B-C	-4.3931	-4.7523	-187.575	-196.7204	110	6	6	9364	6	59	50
B-M	-27.7121	-48.7066	-199.941	-276.3597	94	16	11	8373	9	39	45
B-O	0.0	0.0	-0.0067	-0.0067	2	0	0	4	0	2	1
C-D	-7.9879	-16.8869	-84.609	-109.4837	49	5	3	4446	0	17	17
C-I	-32.489	-27.4783	504.913	444.9457	58	17	3	5565	5	32	41
C-O	0.0	-33.4002	-28.7093	-62.1095	27	1	0	1092	3	32	34
D-G	0.0	0.0	-0.0332	-0.0332	5	0	0	12	0	3	0
D-H	-4.1639	-41.6794	-87.8161	-133.6594	44	10	2	3469	3	26	31
D-I	0.0	0.0	-0.1812	-0.1812	7	0	0	25	0	2	1
D-L	-2.6656	-30.8942	-80.65	-114.2098	43	13	3	3374	2	26	32
E-F	0.0	16.0805	546.717	562.7975	51	14	6	4768	0	16	14
E-G	0.0	-5.2977	-47.4984	-52.7961	21	1	0	1901	0	9	10
E-H	-3.8041	26.7202	-263.103	-240.1869	117	31	3	12435	3	34	44
E-K	-27.0542	-39.6263	499.631	432.9506	59	12	4	5712	6	32	41
E-L	0.0	0.0	-0.2227	-0.2227	7	0	0	33	0	2	1
E-N	0.0	25.4701	-48.0491	-22.579	37	2	1	2001	0	16	18
F-G	-15.3582	4.598	-225.023	-235.7832	112	9	7	10456	6	60	57
F-M	0.0	0.0	-0.4748	-0.4748	8	0	0	81	0	4	4
F-N	-22.5295	-11.7096	-159.694	-193.933	86	8	11	7401	6	29	45
G-H	0.0	-19.9902	-77.2743	-97.2645	49	4	3	4500	0	19	17
G-M	-4.629	29.1332	-42.2093	-17.7051	34	0	0	1800	0	13	22
H-K	0.0	0.0	-0.0039	-0.0039	4	0	0	4	0	3	0
H-L	-3.8916	-29.5133	-83.6925	-117.0974	43	6	2	3241	3	25	30
I-J	0.0	2.9063	465.699	468.6053	53	7	7	4852	0	15	15
I-K	0.0	-7.4303	-57.0208	-64.4511	24	4	0	2146	2	9	12
I-L	0.0	24.8274	-242.546	-217.7186	113	17	2	11339	2	33	42
I-O	0.0	-0.2276	-55.1026	-55.3302	39	7	1	2810	0	29	35
J-K	-10.4255	-0.7175	-198.263	-209.406	113	4	6	9663	5	60	52
J-N	0.0	0.0	-0.0087	-0.0087	5	0	0	5	0	4	3
J-O	-10.9637	-35.0953	-140.184	-186.243	84	1	8	6124	6	42	28
K-L	-12.1791	-18.8444	-85.9894	-117.0129	51	5	3	4586	0	17	17
K-N	0.0	-7.4429	-33.6377	-41.0806	32	0	0	1666	0	30	24
M-N	-8.5825	-111.0348	-231.52	-351.1373	127	8	12	11403	8	51	51
M-O	-47.4382	-114.782	-189.112	-351.3322	118	19	11	9775	6	54	68
N-O	-40.7816	-145.2124	-230.337	-416.331	126	22	18	11941	5	62	68

Interface residues

• A-B: ALA129B, ALA33A, ALA37A, ARG121A, ARG123B, ARG127B, ARG18B, ARG30A, ARG31A, ARG36A, ASP126B, ASP21A, ASP29A, ASP40A, ASP41A, ASP80B, CYS124B, CYS129A, GLN125A, GLN3B, GLN81B, GLU15B, GLU8B, GLY5B, GLY9B, HIS17A, ILE34A, LEU10B, LEU121B, LEU123A, LEU127A, LEU7B, LYS11B, LYS13B, LYS2B, PHE130A, PRO124A, SER128A, SER14B, SER24A, TRP130B, TYR125B, VAL122A, VAL126A, VAL12B, VAL22A, VAL32A, VAL38A, VAL6B
• A-C: ALA33A, ARG24C, ARG30A, ARG31A, ASP20A, ASP21A, ASP25C, ASP29A, GLU27C, GLY34C, ILE31C, LEU22C, LYS30C, PHE27A, SER24A, SER25A, SER26A, SER28C, SER29C, THR26C, THR28A, TRP23A, VAL22A
• A-D: ALA22D, ALA28D, ALA33D, ALA68D, ALA74A, ALA91D, ALA92D, ALA95D, ARG104A, ARG104D, ARG16A, ARG31A, ARG31D, ARG36A, ARG55A, ARG55D, ARG57D, ARG72A, ARG72D, ASN75A, ASN82A, ASP20A, ASP29A, ASP78D, ASP85A, ASP85D, ASP86A, ASP88D, ASP99A, GLN100A, GLN100D, GLN103A, GLN71D, GLN91A, GLN93D, GLU30D, GLU62A, GLU65A, GLU65D, GLY26D, GLY64A, GLY67D, GLY76A, GLY76D, GLY95A, HIS17A, HIS27D, HIS29D, HIS69A, HIS69D, HIS93A, HIS96A, HIS96D, ILE79D, ILE81A, ILE81D, LEU15D, LEU19D, LEU70A, LEU74D, LEU77A, LEU77D, LEU79A, LEU80A, LEU83A, LEU84A, LEU84D, LEU88A, LEU90A, LEU90D, LEU94A, LEU94D, LEU97A, LEU97D, LYS16D, LYS18D, LYS67A, LYS78A, MET83D, MET89D, PHE25D, PHE27A, PHE66A, PHE66D, PRO64D, PRO87D, SER14D, SER24A, SER25A, SER26A, SER63A, SER63D, SER68A, SER70D, SER75D, SER82D, SER92A, THR12D, THR28A, THR80D, THR86D, THR87A, TRP19A, TRP21D, TRP23A, TYR62D, VAL11D, VAL17D, VAL32A, VAL32D, VAL56A, VAL56D, VAL71A, VAL73A, VAL73D, VAL89A, VAL99D
• A-G: ALA121G, ALA133G, ALA134A, ALA135G, ARG12A, ARG137A, ARG13A, ARG13G, ARG141A, ARG145A, ARG16A, ASN131A, ASP11A, ASP11G, ASP129G, ASP130G, ASP132G, ASP133A, ASP5A, ASP5A5, ASP85A, ASP86A, CB7.89377-5.67489, CYS138A, CYS6A, CYS6G, CYS7A, CYS7G, GLN126G, GLN18G, GLN91A, GLU10A, GLU10G, GLU4G, GLU9G, HIS12G, HIS3G, HIS5G, ILE14G, LEU124G, LEU128G, LEU134G, LEU142A, LEU83A, LEU84A, LEU88A, LEU90A, LEU94A, LYS137G, LYS141G, LYS17G, PRO125G, SER138G, SER8A, SER8G, THR122G, THR87A, TRP136G, TYR131G, TYR9A, VAL15G, VAL89A
• A-H: ASP85A, ASP86A, HIS129H, LEU88A, LYS16H, THR128H, VAL89A
• A-M: ALA134A, ALA181M, ARG137A, ARG13A, ARG168M, ASN131A, ASP11A, ASP133A, CYS120M, CYS129A, CYS217M, GLU10A, GLU121M, GLU14A, GLU188M, GLY185M, GLY189M, HIS17A, ILE15A, ILE18A, LEU127A, LEU214M, LYS184M, PHE130A, PHE215M, PRO124A, PRO182M, PRO211M, SER119M, SER128A, SER187M, SER212M, SER213M, SER8A, THR118M, TYR190M, TYR9A, VAL132A, VAL210M, VAL216M
• B-C: ALA60B, ALA63B, ALA65B, ALA69C, ALA71C, ALA75B, ALA81C, ALA83B, ALA90C, ALA93C, ALA94C, ARG105C, ARG18B, ARG26B, ARG50B, ARG56C, ARG67B, ARG73C, ARG99B, ASN76C, ASN83C, ASP20C, ASP58C, ASP66B, ASP73B, ASP79C, ASP80B, ASP86C, ASP87C, ASP90B, ASP92C, ASP96C, GLN101C, GLN16C, GLN81B, GLN95B, GLU15B, GLU27B, GLU27C, GLU63C, GLU87B, GLU88B, GLY17B, GLY21B, GLY23B, GLY64C, GLY70B, GLY71B, GLY77C, HIS100C, HIS12C, HIS24B, HIS58B, HIS64B, HIS70C, HIS91B, HIS97C, ILE31C, ILE33C, ILE62B, ILE74B, ILE74C, ILE76B, ILE82C, LEU10B, LEU69B, LEU72B, LEU72C, LEU75C, LEU79B, LEU80C, LEU84C, LEU85B, LEU85C, LEU89B, LEU91C, LEU92B, LEU95C, LEU98C, LYS13B, LYS30C, LYS32C, LYS66C, LYS86B, PHE61B, PHE67C, PRO59B, PRO65C, PRO82B, PRO88C, PRO89C, SER14B, SER22B, SER28C, SER29C, SER30B, SER57B, SER68C, SER77B, THR26C, THR78B, THR84B, TRP16B, TRP19C, TRP23C, TYR20B, VAL51B, VAL57C, VAL68B, VAL94B
• B-M: ALA108B, ALA112B, ALA118B, ALA119B, ALA181M, ALA19B, ALA28B, ALA32B, ALA36B, ALA39B, ARG123B, ARG127B, ARG137M, ARG144M, ARG168M, ARG18B, ARG26B, ARG35B, ARG45B, ASN143M, ASN172M, ASP126B, ASP25B, ASP55B, ASP63M, ASP79M, ASP84M, ASP88M, ASP94M, CYS124B, CYS76M, CYS83M, GLN120B, GLN31B, GLN40B, GLU27B, GLU64M, GLU66M, GLU86M, GLU95M, GLY122B, GLY169M, GLY191M, GLY21B, GLY23B, GLY85M, HIS115B, HIS136M, HIS24B, HIS65M, HIS78M, ILE113B, ILE193M, ILE33B, ILE77M, LEU114B, LEU121B, LEU179M, LEU180M, LEU214M, LEU80M, LEU81M, LYS11B, LYS138M, LYS184M, LYS87M, PHE140M, PHE141M, PHE170M, PHE215M, PHE29B, PHE38B, PHE82M, PRO142M, PRO182M, PRO211M, SER139M, SER212M, SER213M, SER22B, SER30B, SER57B, THR111B, THR37B, THR56B, TRP146M, TYR125B, TYR20B, VAL116B, VAL117B, VAL192M, VAL209M, VAL210M, VAL41B
• B-O: HIS116O, HIS24B
• C-D: ALA134D, ALA22D, ARG24C, ARG37C, ASP129C, ASP130C, ASP131D, ASP20C, ASP25C, ASP85D, GLN126C, GLN20D, GLU13D, GLU27C, GLY123C, GLY34C, GLY36C, HIS129D, ILE21C, ILE31C, ILE33C, LEU10D, LEU124C, LEU126D, LEU128C, LEU15D, LEU19D, LEU22C, LEU38C, LEU39C, LYS16D, LYS18D, LYS30C, LYS32C, PHE130D, PHE35C, PRO125C, SER14D, SER23D, SER28C, THR122C, THR128D, THR12D, THR86D, TRP23C, TYR131C, VAL11D, VAL127C, VAL17D
• C-I: ALA121C, ALA133C, ALA134I, ALA135C, ARG12I, ARG137I, ARG13C, ARG13I, ARG141I, ARG145I, ARG16I, ASP11C, ASP11I, ASP129C, ASP130C, ASP132C, ASP133I, ASP5I, ASP85I, ASP86I, CYS138I, CYS6C, CYS6I, CYS7C, CYS7I, GLN126C, GLN18C, GLN91I, GLU10C, GLU10I, GLU4C, GLU9C, HIS12C, HIS3C, HIS5C, ILE14C, LEU124C, LEU128C, LEU134C, LEU142I, LEU83I, LEU84I, LEU88I, LEU90I, LEU94I, LYS137C, LYS141C, LYS17C, PRO125C, SER138C, SER8C, SER8I, THR122C, THR87I, TRP136C, TYR131C, TYR9I, VAL15C
• C-O: ARG120O, ARG121O, ARG13C, ASP115O, ASP155O, ASP184O, ASP86C, ASP92C, CYS117O, CYS213O, GLU10C, GLU156O, GLU183O, GLU211O, GLU4C, GLU9C, HIS116O, HIS12C, HIS206O, HIS5C, LEU186O, LYS119O, PRO88C, PRO89C, SER8C, THR118O, VAL212O
• D-G: ASP129G, ASP130G, HIS29D, PRO125G, PRO64D
• D-H: ALA134H, ALA33D, ARG125H, ARG31D, ARG40D, ARG57D, ASN60D, ASP124H, ASP131H, ASP137H, ASP41D, ASP44D, ASP45H, ASP59D, GLU30D, GLU37D, GLY123H, GLY127H, GLY133H, GLY67D, HIS117H, HIS120H, HIS129H, HIS136H, HIS29D, ILE43D, ILE61D, LEU119H, LEU122H, LEU126H, LEU36D, LYS116H, LYS50D, PHE130H, PHE132H, PHE34D, PRO47D, PRO64D, SER63D, THR128H, TRP135H, TYR62D, VAL121H, VAL32D
• D-I: ASP85I, ASP86I, HIS129D, LEU88I, LYS16D, THR128D, VAL89I
• D-L: ALA134D, ALA33L, ARG125D, ARG31L, ARG40L, ARG57L, ASN60L, ASP124D, ASP131D, ASP137D, ASP41L, ASP44L, ASP45D, ASP45L, ASP59L, GLU30L, GLU37L, GLY123D, GLY127D, GLY133D, HIS117D, HIS120D, HIS129D, HIS136D, HIS29L, ILE61L, LEU119D, LEU122D, LEU126D, LEU36L, LYS116D, LYS50L, PHE130D, PHE132D, PHE34L, PRO47L, PRO64L, SER63L, THR128D, TRP135D, TYR62L, VAL121D, VAL32L
• E-F: ALA129F, ALA33E, ALA37E, ARG121E, ARG123F, ARG127F, ARG18F, ARG30E, ARG31E, ARG36E, ASP126F, ASP20E, ASP21E, ASP29E, ASP41E, ASP80F, CYS124F, CYS129E, GLN125E, GLN3F, GLN81F, GLU15F, GLU8F, GLY5F, GLY9F, HIS17E, ILE34E, LEU10F, LEU121F, LEU123E, LEU127E, LEU7F, LYS11F, LYS13F, LYS2F, PHE130E, PRO124E, SER128E, SER14F, SER24E, SER25E, TRP130F, TYR125F, VAL122E, VAL126E, VAL12F, VAL22E, VAL32E, VAL35E, VAL38E, VAL6F
• E-G: ARG24G, ARG30E, ARG31E, ASP20E, ASP21E, ASP25G, ASP29E, GLU27G, GLY34G, ILE31G, LEU22G, LYS30G, PHE27E, SER24E, SER25E, SER26E, SER28G, THR26G, THR28E, TRP23E, VAL22E
• E-H: ALA22H, ALA28H, ALA33H, ALA68H, ALA74E, ALA91H, ALA92H, ALA95H, ARG104E, ARG104H, ARG16E, ARG31E, ARG31H, ARG36E, ARG55E, ARG55H, ARG72E, ARG72H, ASN75E, ASN82E, ASP20E, ASP29E, ASP78H, ASP85E, ASP85H, ASP86E, ASP88H, ASP99E, GLN100E, GLN100H, GLN103E, GLN20H, GLN71H, GLN91E, GLN93H, GLU30H, GLU62E, GLU65E, GLU65H, GLY26H, GLY64E, GLY67H, GLY76E, GLY76H, GLY95E, HIS17E, HIS27H, HIS29H, HIS69E, HIS69H, HIS93E, HIS96E, HIS96H, ILE79H, ILE81E, ILE81H, LEU15H, LEU19H, LEU70E, LEU74H, LEU77E, LEU77H, LEU79E, LEU80E, LEU83E, LEU84E, LEU84H, LEU88E, LEU90E, LEU90H, LEU94E, LEU94H, LEU97E, LEU97H, LYS16H, LYS18H, LYS67E, LYS78E, MET83H, MET89H, PHE25H, PHE27E, PHE66E, PHE66H, PRO64H, PRO87H, SER14H, SER24E, SER25E, SER26E, SER63E, SER63H, SER68E, SER70H, SER75H, SER82H, SER92E, THR12H, THR28E, THR80H, THR86H, THR87E, TRP19E, TRP21H, TRP23E, TYR62H, VAL11H, VAL17H, VAL32E, VAL32H, VAL56E, VAL56H, VAL71E, VAL73E, VAL73H, VAL89E, VAL99H
• E-K: ALA121K, ALA133K, ALA134E, ALA135K, ARG12E, ARG137E, ARG13E, ARG13K, ARG141E, ARG145E, ARG16E, ASP11E, ASP11K, ASP129K, ASP130K, ASP132K, ASP133E, ASP5E, ASP85E, ASP86E, CYS138E, CYS6E, CYS6K, CYS7E, CYS7K, GLN126K, GLN18K, GLN91E, GLU10E, GLU10K, GLU4K, GLU9K, HIS12K, HIS3K, HIS5K, ILE14K, LEU124K, LEU128K, LEU134K, LEU142E, LEU83E, LEU84E, LEU88E, LEU90E, LEU94E, LYS137K, LYS141K, LYS17K, PRO125K, SER138K, SER8E, SER8K, THR122K, THR87E, TRP136K, TYR131K, TYR9E, VAL15K, VAL89E
• E-L: ASP85E, ASP86E, HIS129L, LEU88E, LYS16L, THR128L, VAL89E
• E-N: ALA134E, ALA213N, ARG137E, ARG13E, ARG16E, ASN131E, ASP11E, ASP133E, ASP188N, ASP189N, ASP21E, CYS120N, CYS129E, CYS218N, GLN217N, GLU10E, GLU14E, GLU212N, GLY119N, HIS118N, HIS17E, HIS187N, HIS216N, ILE15E, ILE18E, LEU121N, LEU127E, LEU182N, LEU191N, LEU215N, PHE130E, SER128E, SER8E, THR211N, THR214N, TYR9E, VAL132E
• F-G: ALA60F, ALA63F, ALA65F, ALA69G, ALA71G, ALA75F, ALA81G, ALA83F, ALA90G, ALA93G, ALA94G, ARG105G, ARG18F, ARG26F, ARG50F, ARG56G, ARG67F, ARG73G, ARG99F, ASN76G, ASN83G, ASP20G, ASP25G, ASP58G, ASP66F, ASP73F, ASP79G, ASP80F, ASP86G, ASP87G, ASP90F, ASP92G, ASP96G, GLN101G, GLN16G, GLN81F, GLN95F, GLU15F, GLU27F, GLU27G, GLU63G, GLU87F, GLU88F, GLU9G, GLY17F, GLY21F, GLY23F, GLY64G, GLY70F, GLY71F, GLY77G, HIS100G, HIS12G, HIS24F, HIS58F, HIS64F, HIS70G, HIS91F, HIS97G, ILE31G, ILE33G, ILE62F, ILE74F, ILE74G, ILE76F, ILE82G, LEU10F, LEU69F, LEU72F, LEU72G, LEU75G, LEU79F, LEU80G, LEU84G, LEU85F, LEU85G, LEU89F, LEU91G, LEU92F, LEU95G, LEU98G, LYS13F, LYS30G, LYS32G, LYS66G, LYS86F, PHE61F, PHE67G, PRO59F, PRO65G, PRO82F, PRO88G, PRO89G, SER14F, SER22F, SER28G, SER29G, SER30F, SER57F, SER68G, SER77F, THR26G, THR78F, THR84F, TRP16F, TRP19G, TRP23G, TYR20F, VAL51F, VAL57G, VAL68F, VAL94F
• F-M: ASN124M, ASP55F, HIS158M, HIS24F, HIS58F, PRO125M, PRO59F, SER57F
• F-N: ALA108F, ALA112F, ALA118F, ALA119F, ALA143N, ALA192N, ALA19F, ALA213N, ALA28F, ALA32F, ALA36F, ALA39F, ARG123F, ARG127F, ARG138N, ARG144N, ARG178N, ARG18F, ARG26F, ARG35F, ARG45F, ARG65N, ASN173N, ASP25F, ASP79N, ASP84N, ASP88N, ASP94N, CYS124F, CYS76N, GLN120F, GLN31F, GLN40F, GLU212N, GLU27F, GLU63N, GLU95N, GLY122F, GLY170N, GLY23F, GLY85N, HIS115F, HIS216N, HIS24F, HIS86N, ILE113F, ILE180N, ILE33F, ILE77N, LEU114F, LEU121F, LEU182N, LEU215N, LEU80N, LEU81N, LYS136N, LYS139N, LYS169N, LYS64N, LYS87N, PHE140N, PHE141N, PHE29F, PHE38F, PRO183N, SER22F, SER30F, SER57F, SER78N, THR111F, THR142N, THR211N, THR214N, THR37F, THR56F, THR66N, TRP146N, TRP34F, TYR125F, TYR171N, VAL116F, VAL117F, VAL194N, VAL210N, VAL41F, VAL82N
• G-H: ALA134H, ALA22H, ARG24G, ARG37G, ASP129G, ASP130G, ASP131H, ASP20G, ASP25G, ASP85H, GLN126G, GLN20H, GLU13H, GLU27G, GLY123G, GLY34G, GLY36G, HIS129H, ILE21G, ILE31G, ILE33G, LEU10H, LEU124G, LEU126H, LEU128G, LEU15H, LEU19H, LEU22G, LEU38G, LEU39G, LYS16H, LYS18H, LYS30G, LYS32G, PHE130H, PHE35G, PRO125G, SER14H, SER23H, SER28G, THR122G, THR128H, THR12H, THR86H, TRP23G, TYR131G, VAL11H, VAL127G, VAL17H
• G-M: ALA218M, ALA90G, ARG13G, ASN124M, ASP11G, ASP122M, ASP156M, ASP86G, ASP87G, CYS120M, CYS217M, CYS6G, CYS7G, GLU10G, GLU121M, GLU188M, GLU4G, GLU9G, HIS12G, HIS158M, HIS5G, LEU123M, LEU85G, PHE215M, PRO125M, PRO88G, PRO89G, SER119M, SER187M, SER8G, THR118M, TRP117M, TYR190M, VAL216M
• H-K: ASP130K, HIS29H, PRO125K, PRO64H
• H-L: ALA134L, ALA33H, ARG125L, ARG31H, ARG40H, ARG57H, ASN60H, ASP124L, ASP131L, ASP137L, ASP41H, ASP44H, ASP45L, ASP59H, GLU30H, GLU37H, GLY123L, GLY127L, GLY133L, GLY67H, HIS117L, HIS120L, HIS129L, HIS136L, HIS29H, ILE61H, LEU119L, LEU122L, LEU126L, LEU36H, LYS116L, LYS50H, PHE130L, PHE132L, PHE34H, PRO47H, PRO64H, SER63H, THR128L, TRP135L, TYR62H, VAL121L, VAL32H
• I-J: ALA129J, ALA33I, ALA37I, ARG121I, ARG123J, ARG127J, ARG18J, ARG30I, ARG31I, ARG36I, ASP126J, ASP20I, ASP21I, ASP29I, ASP40I, ASP41I, ASP80J, CYS124J, CYS129I, GLN125I, GLN3J, GLN81J, GLU15J, GLU8J, GLY5J, GLY9J, HIS17I, ILE18I, ILE34I, LEU10J, LEU121J, LEU123I, LEU127I, LEU7J, LYS11J, LYS13J, LYS2J, PHE130I, PRO124I, SER128I, SER14J, SER24I, SER25I, TRP130J, TYR125J, VAL122I, VAL126I, VAL12J, VAL22I, VAL32I, VAL35I, VAL38I, VAL6J
• I-K: ALA33I, ARG24K, ARG30I, ARG31I, ASP20I, ASP21I, ASP25K, ASP29I, GLU27K, GLY34K, ILE31K, LEU22K, LYS30K, LYS32K, PHE27I, SER24I, SER25I, SER26I, SER28K, SER29K, THR26K, THR28I, TRP23I, VAL22I
• I-L: ALA22L, ALA28L, ALA33L, ALA68L, ALA74I, ALA91L, ALA92L, ALA95L, ARG104I, ARG104L, ARG16I, ARG31I, ARG31L, ARG36I, ARG55I, ARG55L, ARG72I, ARG72L, ASN75I, ASN82I, ASP20I, ASP29I, ASP78L, ASP85I, ASP85L, ASP86I, ASP88L, ASP99I, GLN100I, GLN100L, GLN103I, GLN71L, GLN91I, GLN93L, GLU30L, GLU62I, GLU65I, GLU65L, GLY26L, GLY64I, GLY67L, GLY76I, GLY76L, GLY95I, HIS27L, HIS29L, HIS69I, HIS69L, HIS93I, HIS96I, HIS96L, ILE79L, ILE81I, ILE81L, LEU15L, LEU19L, LEU70I, LEU74L, LEU77I, LEU77L, LEU79I, LEU80I, LEU83I, LEU84I, LEU84L, LEU88I, LEU90I, LEU90L, LEU94I, LEU94L, LEU97I, LEU97L, LYS18L, LYS67I, LYS78I, MET83L, MET89L, PHE25L, PHE27I, PHE66I, PHE66L, PRO64L, PRO87L, SER14L, SER24I, SER25I, SER26I, SER63I, SER63L, SER68I, SER70L, SER75L, SER82L, SER92I, THR28I, THR80L, THR86L, THR87I, TRP19I, TRP21L, TRP23I, TYR62L, VAL11L, VAL17L, VAL32I, VAL32L, VAL56I, VAL56L, VAL71I, VAL73I, VAL73L, VAL89I, VAL99L
• I-O: ALA134I, ARG121O, ARG137I, ARG13I, ARG16I, ASN131I, ASP11I, ASP133I, ASP184O, ASP21I, CYS117O, CYS129I, CYS213O, GLU10I, GLU14I, GLU182O, GLU183O, GLU207O, GLU210O, GLU211O, GLY185O, HIS116O, HIS179O, HIS17I, HIS206O, ILE15I, ILE18I, LEU127I, LEU186O, LEU208O, LYS119O, PHE130I, PRO180O, SER128I, SER209O, SER8I, TRP19I, VAL132I, VAL212O
• J-K: ALA60J, ALA63J, ALA65J, ALA69K, ALA71K, ALA75J, ALA81K, ALA83J, ALA90K, ALA93K, ALA94K, ARG105K, ARG18J, ARG26J, ARG50J, ARG56K, ARG67J, ARG73K, ARG99J, ASN76K, ASN83K, ASP20K, ASP25K, ASP58K, ASP66J, ASP73J, ASP79K, ASP80J, ASP86K, ASP87K, ASP90J, ASP92K, ASP96K, GLN101K, GLN16K, GLN81J, GLN95J, GLU15J, GLU27J, GLU27K, GLU63K, GLU87J, GLU88J, GLU9K, GLY17J, GLY21J, GLY23J, GLY64K, GLY70J, GLY71J, GLY77K, HIS100K, HIS12K, HIS24J, HIS58J, HIS64J, HIS70K, HIS91J, HIS97K, ILE31K, ILE33K, ILE62J, ILE74J, ILE74K, ILE76J, ILE82K, LEU10J, LEU69J, LEU72J, LEU72K, LEU75K, LEU79J, LEU80K, LEU84K, LEU85J, LEU85K, LEU89J, LEU91K, LEU92J, LEU95K, LEU98K, LYS13J, LYS17K, LYS30K, LYS32K, LYS66K, LYS86J, PHE61J, PHE67K, PRO59J, PRO65K, PRO82J, PRO88K, PRO89K, SER14J, SER22J, SER28K, SER29K, SER30J, SER57J, SER68K, SER77J, THR26K, THR78J, THR84J, TRP16J, TRP19K, TRP23K, TYR20J, VAL51J, VAL57K, VAL68J, VAL94J
• J-N: GLU124N, HIS118N, HIS24J, PRO59J, TRP117N
• J-O: ALA108J, ALA112J, ALA118J, ALA119J, ALA135O, ALA136O, ALA172O, ALA19J, ALA28J, ALA32J, ALA36J, ALA39J, ARG123J, ARG175O, ARG18J, ARG26J, ARG35J, ARG45J, ASN87O, ASP143O, ASP25J, ASP55J, ASP63O, ASP84O, ASP88O, ASP94O, CYS124J, GLN120J, GLN31J, GLN40J, GLU168O, GLU207O, GLU210O, GLU27J, GLU64O, GLU66O, GLU95O, GLY122J, GLY167O, GLY187O, GLY21J, GLY85O, HIS115J, HIS179O, HIS206O, HIS24J, HIS65O, HIS86O, ILE134O, ILE141O, ILE178O, ILE33J, ILE62J, ILE77O, LEU114J, LEU121J, LEU208O, LEU80O, LYS79O, PHE137O, PHE138O, PHE29J, PHE38J, PHE81O, PRO140O, PRO180O, SER170O, SER209O, SER30J, SER57J, SER78O, THR111J, THR139O, THR177O, THR37J, THR56J, TRP34J, TYR125J, VAL116J, VAL117J, VAL189O, VAL205O, VAL41J, VAL82O
• K-L: ALA134L, ALA22L, ARG24K, ARG37K, ASP129K, ASP130K, ASP131L, ASP20K, ASP25K, ASP85L, GLN126K, GLN20L, GLU13L, GLU27K, GLY123K, GLY34K, GLY36K, HIS129L, ILE21K, ILE31K, ILE33K, LEU10L, LEU124K, LEU126L, LEU128K, LEU15L, LEU19L, LEU22K, LEU38K, LEU39K, LYS16L, LYS18L, LYS30K, LYS32K, LYS42K, PHE130L, PHE35K, PRO125K, SER14L, SER23L, SER28K, THR122K, THR128L, THR12L, THR41K, THR86L, TRP23K, TYR131K, VAL11L, VAL127K, VAL17L
• K-N: ALA122N, ALA219N, ALA90K, ARG123N, ARG13K, ARG157N, ASP11K, ASP188N, ASP189N, ASP86K, ASP87K, CYS120N, CYS218N, CYS6K, CYS7K, GLN217N, GLU10K, GLU124N, GLU4K, GLU9K, GLY119N, HIS118N, HIS12K, HIS216N, HIS5K, LEU121N, LEU191N, LEU85K, PRO88K, PRO89K, SER8K, TRP117N
• M-N: ALA115M, ALA128M, ALA16N, ALA18N, ALA204M, ALA222M, ALA25M, ALA38N, ALA52M, ALA52N, ARG13N, ARG224M, ARG23N, ARG26N, ARG32N, ARG53M, ARG53N, ASN124M, ASN17N, ASN18M, ASN221M, ASN36M, ASN56M, ASN72N, ASN91N, ASP11N, ASP126M, ASP205M, ASP22M, ASP25N, ASP30M, ASP36N, ASP41M, ASP42N, ASP43M, ASP51N, CYS62N, CYS69N, CYS76N, CYS89N, GLN17M, GLN223M, GLN49M, GLN68N, GLN74N, GLU154M, GLU157M, GLU29N, GLU32M, GLU33M, GLU34M, GLU37N, GLU39N, GLU44N, GLU49N, GLU58N, GLU73N, GLU75N, GLY113M, GLY15N, GLY59N, GLY70N, GLY71N, HIS127M, HIS203M, HIS20M, HIS219M, HIS29M, HIS40M, HIS45N, HIS61N, HIS90N, ILE21M, ILE21N, ILE22N, ILE27N, ILE28N, ILE31M, ILE41N, ILE47M, ILE50N, ILE54M, ILE57N, ILE77N, LEU114M, LEU13M, LEU14N, LEU198M, LEU20N, LEU24M, LEU24N, LEU28M, LEU31N, LEU35N, LEU38M, LEU50M, LEU57M, LYS26M, LYS27M, LYS30N, LYS34N, LYS37M, LYS40N, LYS51M, LYS56N, PHE10M, PHE220M, PHE46N, PRO125M, PRO43N, SER48N, SER55M, THR112M, THR116M, THR33N, THR39M, THR46M, THR55N, TYR111M, TYR12M, TYR225M, TYR23M, TYR35M, VAL14M, VAL42M, VAL47N, VAL54N
• M-O: ALA25M, ALA47O, ALA52M, ARG199O, ARG20O, ARG38O, ARG43O, ARG48M, ARG51O, ARG53M, ARG53O, ARG90M, ASN16M, ASN18M, ASN196O, ASN22O, ASN36M, ASN56M, ASP111O, ASP115O, ASP22M, ASP36O, ASP37O, ASP41M, ASP72M, ASP91M, CYS113O, CYS213O, CYS69M, CYS76M, GLN11M, GLN17M, GLN49M, GLU123O, GLU19O, GLU215O, GLU32M, GLU32O, GLU33M, GLU55O, GLU56O, GLU58M, GLU58O, GLU59M, GLU68M, GLU75M, GLY110O, GLY71M, HIS10O, HIS116O, HIS124O, HIS203O, HIS20M, HIS219O, HIS29M, HIS30O, HIS40M, HIS52O, HIS60M, HIS61M, ILE13O, ILE14O, ILE18O, ILE217O, ILE21M, ILE24O, ILE28O, ILE31M, ILE47M, ILE54M, LEU13M, LEU17O, LEU19M, LEU24M, LEU28M, LEU34O, LEU35O, LEU38M, LEU39O, LEU50M, LEU50O, LEU57M, LEU57O, LYS15M, LYS16O, LYS23O, LYS26M, LYS27M, LYS37M, LYS44M, LYS46O, LYS51M, PHE10M, PHE114O, PHE216O, PHE218O, PRO122O, PRO74M, SER27O, SER29O, SER49O, SER55M, SER9O, THR21O, THR25O, THR26O, THR39M, THR46M, TYR23M, TYR35M, VAL112O, VAL14M, VAL201O, VAL212O, VAL31O, VAL42M, VAL54O, VAL73M
• N-O: ALA16N, ALA18N, ALA205N, ALA38N, ALA47O, ALA52N, ARG13N, ARG199N, ARG204N, ARG20O, ARG23N, ARG26N, ARG32N, ARG38O, ARG43O, ARG51O, ARG53N, ARG53O, ARG90O, ASN17N, ASN198N, ASN22O, ASP11O, ASP125N, ASP15O, ASP201N, ASP220N, ASP25N, ASP36N, ASP36O, ASP37O, ASP40O, ASP42N, ASP51N, ASP59O, ASP72O, ASP73O, CYS76O, GLN68O, GLN75O, GLU12O, GLU19O, GLU203N, GLU206N, GLU29N, GLU32O, GLU37N, GLU39N, GLU44N, GLU49N, GLU55O, GLU56O, GLU58N, GLU58O, GLY113N, GLY48O, GLY70O, GLY71O, HIS10O, HIS126N, HIS30O, HIS45N, HIS52O, ILE13O, ILE14O, ILE18O, ILE21N, ILE22N, ILE24O, ILE27N, ILE28N, ILE28O, ILE41N, ILE44O, ILE50N, ILE57N, LEU10N, LEU14N, LEU17O, LEU20N, LEU221N, LEU225N, LEU24N, LEU31N, LEU34O, LEU35N, LEU35O, LEU39O, LEU50O, LEU57O, LYS16O, LYS23O, LYS30N, LYS34N, LYS40N, LYS46O, LYS56N, PHE19N, PHE222N, PHE46N, PRO41O, PRO43N, PRO74O, SER112N, SER115N, SER27O, SER29O, SER33O, SER49O, SER61O, THR114N, THR116N, THR128N, THR21O, THR224N, THR25O, THR26O, THR33N, THR55N, TYR195O, VAL127N, VAL223N, VAL31O, VAL47N, VAL54N, VAL54O