2GSE

crystal structure of human dihydropyrimidinease-like 2

• Total interactions analyzed: 6
• Total true interactions: 6
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 135
  • Norm. En. per Res.: -3.061
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-63.272	-70.4792	-260.277	-394.0282	131	6	2	11683	2	70	50
A-C	-23.392	67.6385	-216.073	-171.8265	114	5	4	9499	0	51	41
A-D	0.0	0.0	-0.8656	-0.8656	8	0	0	185	0	5	5
B-C	0.0	0.0	-0.9218	-0.9218	8	0	0	170	0	5	5
B-D	-26.1162	38.8868	-242.929	-230.1584	115	1	4	10101	3	54	47
C-D	-59.784	-88.6794	-264.775	-413.2384	135	10	0	11872	5	71	51

Interface residues

• A-B: ALA261A, ALA261B, ALA265A, ALA265B, ALA267A, ALA267B, ALA369A, ALA369B, ALA402A, ALA402B, ALA484A, ALA484B, ARG268A, ARG268B, ARG397A, ARG397B, ARG400A, ARG400B, ARG440A, ARG440B, ARG481A, ARG481B, ARG485A, ARG485B, ARG487A, ARG487B, ASN26A, ASN26B, ASN378A, ASN378B, ASP27A, ASP27B, ASP28A, ASP28B, ASP315A, ASP315B, ASP325A, ASP325B, ASP376A, ASP376B, ASP415A, ASP476A, ASP476B, CYS323A, CYS323B, GLN266A, GLN266B, GLN29A, GLN29B, GLN327B, GLN379A, GLN379B, GLU262A, GLU262B, GLU377A, GLU377B, GLY271A, GLY271B, GLY324A, GLY324B, GLY373A, GLY373B, ILE24A, ILE24B, ILE482A, ILE482B, LEU320A, LEU320B, LEU321B, LEU488A, LEU488B, LYS23A, LYS23B, LYS258B, LYS269A, LYS269B, LYS270A, LYS270B, LYS374A, LYS374B, LYS390A, LYS390B, LYS480A, LYS480B, LYS483A, LYS483B, MET375A, MET375B, MET64A, MET64B, PHE316A, PHE316B, PHE31A, PHE31B, PHE477A, PHE477B, PRO396A, PRO396B, PRO414A, SER30A, SER30B, SER319A, SER319B, SER322A, SER322B, SER405A, SER486A, SER486B, THR272A, THR272B, THR372A, THR372B, THR386A, THR386B, TRP366A, TYR275A, TYR275B, TYR395A, TYR395B, TYR479A, TYR479B, VAL25A, VAL25B, VAL273A, VAL273B, VAL370A, VAL370B, VAL371A, VAL371B, VAL478A, VAL478B
• A-C: ALA206A, ALA206C, ALA233A, ALA233C, ALA235A, ALA235C, ALA239A, ALA239C, ALA243A, ALA243C, ALA489A, ALA489C, ARG189A, ARG189C, ARG211A, ARG211C, ARG227A, ARG227C, ARG238A, ARG238C, ASN201A, ASN201C, ASN237A, ASN237C, ASN244A, ASN244C, ASN247A, ASP178A, ASP178C, ASP203A, ASP203C, CYS179A, CYS179C, GLN175A, GLN175C, GLN180A, GLN180C, GLN209A, GLN209C, GLN210A, GLN210C, GLN245A, GLN245C, GLN266A, GLN266C, GLU183A, GLU183C, GLU207A, GLU207C, GLU208A, GLU208C, GLU229A, GLU229C, GLU230A, GLU230C, GLU232A, GLU232C, GLU234A, GLU234C, GLU262A, GLU262C, GLY202A, GLY202C, ILE181A, ILE181C, ILE204A, ILE204C, ILE205A, ILE205C, ILE212A, ILE212C, ILE217A, ILE217C, ILE240A, ILE240C, ILE242A, ILE242C, LEU215A, LEU215C, LEU225A, LEU225C, LYS171A, LYS171C, LYS258A, LYS258C, LYS270A, LYS270C, MET168A, MET168C, PRO228A, PRO228C, SER186A, SER186C, SER226A, SER226C, SER259A, SER259C, SER486C, THR177A, THR177C, THR241A, THR241C, THR246A, THR246C, THR272A, THR272C, TYR182A, TYR182C, VAL231A, VAL231C, VAL236A, VAL236C, VAL263A, VAL263C
• A-D: ASP310A, ASP310D, LYS258A, LYS258D, PRO311A, PRO311D, THR312A, THR312D
• B-C: ASP310B, ASP310C, LYS258B, LYS258C, PRO311B, PRO311C, THR312B, THR312C
• B-D: ALA206B, ALA206D, ALA233B, ALA233D, ALA235B, ALA235D, ALA239B, ALA239D, ALA243B, ALA243D, ALA489B, ALA489D, ARG189B, ARG189D, ARG211B, ARG211D, ARG227B, ARG227D, ARG238B, ARG238D, ASN201B, ASN201D, ASN237B, ASN237D, ASN244B, ASN244D, ASP178B, ASP178D, ASP203B, ASP203D, CYS179B, CYS179D, GLN175B, GLN175D, GLN180B, GLN180D, GLN209B, GLN209D, GLN210B, GLN210D, GLN245B, GLN245D, GLN266B, GLN266D, GLU183B, GLU183D, GLU207B, GLU207D, GLU208B, GLU208D, GLU221B, GLU229B, GLU229D, GLU230B, GLU230D, GLU232B, GLU232D, GLU234B, GLU234D, GLU262B, GLU262D, GLU490D, GLY202B, GLY202D, GLY222B, ILE181B, ILE181D, ILE204B, ILE204D, ILE205B, ILE205D, ILE212B, ILE212D, ILE217B, ILE217D, ILE240B, ILE240D, ILE242B, ILE242D, LEU215B, LEU215D, LEU225B, LEU225D, LEU488B, LYS171B, LYS171D, LYS258D, LYS270B, LYS270D, MET168B, MET168D, PRO228B, PRO228D, SER186B, SER186D, SER226B, SER226D, SER259B, SER259D, THR177B, THR177D, THR241B, THR241D, THR246B, THR246D, THR272B, TRP291B, TYR182B, TYR182D, VAL231B, VAL231D, VAL236B, VAL236D, VAL263B, VAL263D
• C-D: ALA261C, ALA261D, ALA265C, ALA265D, ALA267C, ALA267D, ALA369C, ALA369D, ALA402C, ALA402D, ALA484C, ALA484D, ARG268C, ARG268D, ARG397C, ARG397D, ARG400C, ARG400D, ARG440C, ARG440D, ARG481C, ARG481D, ARG485C, ARG485D, ARG487C, ARG487D, ASN26C, ASN26D, ASN378C, ASN378D, ASP27C, ASP27D, ASP28C, ASP28D, ASP315C, ASP315D, ASP325C, ASP325D, ASP367D, ASP376C, ASP376D, ASP476C, ASP476D, CYS323C, CYS323D, GLN266C, GLN266D, GLN29C, GLN29D, GLN327C, GLN327D, GLN379C, GLN379D, GLU262C, GLU262D, GLU377C, GLU377D, GLY271C, GLY271D, GLY324C, GLY324D, GLY373C, GLY373D, ILE24C, ILE24D, ILE264C, ILE482C, ILE482D, LEU320C, LEU320D, LEU488C, LEU488D, LYS23C, LYS23D, LYS258C, LYS258D, LYS269C, LYS269D, LYS270C, LYS270D, LYS374C, LYS374D, LYS390C, LYS390D, LYS480C, LYS480D, LYS483C, LYS483D, MET375C, MET375D, MET64C, MET64D, PHE316C, PHE316D, PHE31C, PHE31D, PHE477C, PHE477D, PRO396C, PRO396D, PRO475C, SER30C, SER30D, SER319C, SER319D, SER322C, SER322D, SER405D, SER486C, SER486D, THR272C, THR272D, THR372C, THR372D, THR386C, THR386D, TRP366C, TRP366D, TYR275C, TYR275D, TYR395C, TYR395D, TYR479C, TYR479D, VAL25C, VAL25D, VAL263C, VAL273C, VAL273D, VAL370C, VAL370D, VAL371C, VAL371D, VAL478C, VAL478D