2GRE

crystal structure of deblocking aminopeptidase from bacillus cereus

• Total interactions analyzed: 120
• Total true interactions: 23
• Strongest Interaction:
  • Chains: C-P
  • Int. Res.: 33
  • Norm. En. per Res.: -5.0124
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-24.9688	13.6006	-173.886	-185.2541	93	8	1	7383	0	29	26
A-C	-22.9903	14.5204	-144.307	-152.7769	90	11	1	6818	0	31	24
A-G	-87.2323	-109.586	-400.057	-596.8753	124	18	1	13980	13	77	71
B-C	-22.3516	11.1265	-162.52	-173.7451	94	10	1	7405	0	32	25
B-J	-71.2975	-75.2104	-384.118	-530.6259	123	19	1	13810	13	81	71
C-E	-70.1695	-79.0998	-414.421	-563.6902	126	23	2	14952	11	82	69
C-M	0.0	0.0	-0.0245	-0.0245	2	0	0	12	0	2	3
C-P	-44.898	-46.9485	-73.5627	-165.4091	33	5	0	2652	3	10	11
D-E	-24.5107	-3.55	-137.366	-165.4267	90	9	2	6259	0	32	27
D-F	-40.1571	21.3039	-171.314	-190.1672	95	8	2	7511	0	37	27
D-H	-83.1147	-82.5112	-393.332	-558.9579	120	22	1	14295	12	80	70
E-F	-14.9169	6.7054	-155.389	-163.6005	89	4	2	6897	0	31	23
F-L	-70.1311	-98.1538	-403.174	-571.4589	127	23	1	14642	13	82	70
G-H	-28.8387	-3.9208	-155.788	-188.5475	89	13	2	6759	0	30	24
G-I	-16.4344	26.1488	-138.669	-128.9546	92	7	2	6398	0	34	26
H-I	-14.8008	-4.112	-154.597	-173.5098	85	9	3	6609	1	30	22
I-K	-44.8747	-119.5737	-379.636	-544.0844	124	14	1	14022	12	82	70
J-K	-31.9827	-1.9491	-155.28	-189.2118	87	16	1	6660	0	30	26
J-L	-5.1763	-5.6498	-155.976	-166.8021	93	10	2	6877	1	33	27
K-L	-23.9633	24.9432	-146.748	-145.7681	90	8	2	6624	0	28	26
M-N	-60.1864	-63.0633	-368.437	-491.6867	120	18	1	13819	11	81	70
M-P	-38.7703	4.9588	-160.084	-193.8955	92	15	1	7237	1	34	25
O-P	-89.3759	-92.9594	-389.768	-572.1033	120	28	2	14064	14	77	70

Interface residues

• A-B: ALA260B, ALA26A, ALA270B, ALA304A, ALA304B, ALA50A, ALA75A, ARG156A, ARG272B, ARG303B, ARG45A, ASN218A, ASN219A, ASN227A, ASN229A, ASN24A, ASN46A, ASN47A, ASP164A, ASP247B, ASP262B, ASP289B, ASP307B, ASP71A, CYS259B, GLN62B, GLU107A, GLU161A, GLU232B, GLU233B, GLU236B, GLU277B, GLU79A, GLY111A, GLY163A, GLY225A, GLY226A, GLY23A, GLY246B, GLY248B, GLY265B, GLY305B, GLY49A, GLY74A, GLY92A, HIS268B, HIS310B, ILE258B, ILE290B, ILE347B, ILE52A, ILE91A, LEU245B, LEU346B, LEU88A, LYS261B, LYS273B, LYS27A, LYS280B, LYS287B, LYS309B, LYS48A, LYS78A, LYS81A, PHE165A, PHE306A, PHE306B, PRO21A, PRO266B, PRO292B, SER109A, SER110A, SER228A, SER22A, SER263B, SER264B, SER87A, SER89A, THR108A, THR234B, THR25A, TRP96A, TYR237B, TYR267B, TYR269B, TYR286B, TYR291B, VAL162A, VAL235B, VAL276B, VAL288B, VAL308B, VAL77A
• A-C: ALA260A, ALA26C, ALA270A, ALA304A, ALA50C, ALA75C, ARG272A, ARG303A, ARG45C, ASN218C, ASN219C, ASN229C, ASN24C, ASN46C, ASN47C, ASP164C, ASP247A, ASP262A, ASP289A, ASP307A, ASP71C, CYS259A, GLN62A, GLU107C, GLU161C, GLU220C, GLU232A, GLU233A, GLU236A, GLU277A, GLU348A, GLU79C, GLY111C, GLY163C, GLY23C, GLY246A, GLY248A, GLY265A, GLY305A, GLY49C, GLY74C, GLY92C, HIS268A, HIS310A, ILE230C, ILE258A, ILE290A, ILE347A, ILE52C, ILE91C, LEU245A, LEU346A, LEU88C, LYS261A, LYS273A, LYS27C, LYS280A, LYS287A, LYS309A, LYS48C, LYS78C, LYS81C, PHE165C, PHE306A, PHE306C, PRO21C, PRO266A, PRO292A, SER109C, SER110C, SER22C, SER263A, SER264A, SER87C, SER89C, THR108C, THR234A, THR25C, TRP96C, TYR237A, TYR267A, TYR269A, TYR286A, TYR291A, VAL162C, VAL235A, VAL276A, VAL288A, VAL308A, VAL77C
• A-G: ALA322A, ARG144A, ARG144G, ARG148A, ARG148G, ARG171A, ARG171G, ARG183A, ARG183G, ARG325A, ARG325G, ARG85A, ARG85G, ARG95A, ARG95G, ASN97A, ASN97G, ASP146A, ASP146G, ASP169A, ASP169G, ASP252A, ASP252G, ASP318A, ASP318G, CYS104A, CYS104G, GLN173A, GLN173G, GLU100A, GLU100G, GLU102A, GLU102G, GLU105A, GLU105G, GLU147A, GLU147G, GLU176A, GLU176G, GLU253A, GLU253G, GLU285G, GLU324A, GLU324G, GLU328A, GLU328G, GLY101A, GLY101G, GLY116A, GLY116G, GLY178A, GLY178G, GLY248G, HIS121A, HIS184A, HIS184G, HIS327A, HIS327G, HIS333A, HIS333G, ILE118A, ILE118G, ILE145A, ILE145G, ILE174A, ILE180A, ILE180G, ILE317A, ILE317G, LEU119A, LEU119G, LEU185A, LEU185G, LYS112A, LYS181A, LYS181G, PHE150A, PHE150G, PHE168A, PHE168G, PHE323A, PHE323G, PRO170A, PRO170G, SER177A, SER177G, SER182A, SER182G, SER251A, SER251G, SER319A, SER319G, SER320A, SER320G, SER329A, SER329G, SER330A, SER330G, SER98A, SER98G, THR115A, THR115G, THR117A, THR117G, THR175A, THR175G, THR326A, THR326G, TYR103A, TYR103G, TYR114A, TYR114G, TYR179A, TYR179G, TYR254A, TYR254G, VAL143A, VAL143G, VAL149A, VAL149G, VAL172A, VAL172G, VAL99A, VAL99G
• B-C: ALA260C, ALA26B, ALA270C, ALA304C, ALA50B, ALA75B, ARG156B, ARG272C, ARG303C, ARG45B, ASN218B, ASN219B, ASN227B, ASN229B, ASN24B, ASN46B, ASN47B, ASP164B, ASP247C, ASP262C, ASP289C, ASP307C, ASP71B, CYS259C, GLN62C, GLU107B, GLU161B, GLU220B, GLU232C, GLU236C, GLU277C, GLU348C, GLU79B, GLY111B, GLY163B, GLY225B, GLY226B, GLY23B, GLY246C, GLY248C, GLY265C, GLY305C, GLY49B, GLY74B, GLY92B, HIS268C, HIS310C, ILE230B, ILE258C, ILE290C, ILE347C, ILE52B, ILE91B, LEU245C, LEU346C, LEU88B, LYS112B, LYS261C, LYS273C, LYS27B, LYS280C, LYS287C, LYS309C, LYS48B, LYS78B, PHE165B, PHE306B, PHE306C, PRO21B, PRO266C, PRO292C, SER109B, SER110B, SER228B, SER22B, SER263C, SER264C, SER87B, SER89B, THR108B, THR234C, THR25B, TRP96B, TYR237C, TYR267C, TYR269C, TYR286C, TYR291C, VAL162B, VAL235C, VAL276C, VAL288C, VAL308C, VAL77B
• B-J: ALA250J, ALA322B, ARG144B, ARG144J, ARG148B, ARG148J, ARG171B, ARG171J, ARG183B, ARG183J, ARG325B, ARG325J, ARG85B, ARG85J, ARG95B, ASN97B, ASN97J, ASP146B, ASP146J, ASP169B, ASP169J, ASP252B, ASP252J, ASP318B, ASP318J, ASP83B, CYS104B, CYS104J, GLN173B, GLN173J, GLU100B, GLU100J, GLU102B, GLU102J, GLU105B, GLU105J, GLU142J, GLU147B, GLU147J, GLU176B, GLU176J, GLU253B, GLU253J, GLU324B, GLU324J, GLU328B, GLU328J, GLY101B, GLY101J, GLY116B, GLY116J, GLY178B, GLY178J, GLY248B, HIS184B, HIS184J, HIS327B, HIS327J, HIS333B, HIS333J, ILE118B, ILE118J, ILE145B, ILE145J, ILE180B, ILE180J, ILE317B, ILE317J, LEU119B, LEU119J, LEU158B, LEU185B, LEU185J, LYS112B, LYS181B, LYS181J, PHE150B, PHE150J, PHE168J, PHE323B, PHE323J, PRO170B, PRO170J, SER177B, SER177J, SER182B, SER182J, SER251B, SER251J, SER319B, SER319J, SER320B, SER320J, SER329B, SER329J, SER330B, SER330J, SER98B, SER98J, THR115B, THR115J, THR117B, THR117J, THR175B, THR175J, THR326B, THR326J, TYR103B, TYR103J, TYR114B, TYR114J, TYR179B, TYR179J, TYR254B, TYR254J, VAL143B, VAL143J, VAL149B, VAL149J, VAL172B, VAL172J, VAL99B, VAL99J
• C-E: ALA322C, ALA322E, ALA332C, ARG144C, ARG144E, ARG148C, ARG148E, ARG171C, ARG171E, ARG183C, ARG183E, ARG325C, ARG325E, ARG85C, ARG85E, ARG95C, ARG95E, ASN97C, ASN97E, ASP146C, ASP146E, ASP169C, ASP169E, ASP252C, ASP252E, ASP318C, ASP318E, ASP83E, CYS104C, CYS104E, GLN173C, GLN173E, GLU100C, GLU100E, GLU102C, GLU102E, GLU105C, GLU105E, GLU147C, GLU147E, GLU176C, GLU176E, GLU253C, GLU253E, GLU285C, GLU324C, GLU324E, GLU328C, GLU328E, GLY101C, GLY101E, GLY116C, GLY116E, GLY178C, GLY178E, GLY248C, HIS184C, HIS184E, HIS327C, HIS327E, HIS333C, HIS333E, ILE118C, ILE118E, ILE145C, ILE145E, ILE180C, ILE180E, ILE317C, ILE317E, LEU119C, LEU119E, LEU158C, LEU158E, LEU185C, LEU185E, LYS181C, LYS181E, PHE150C, PHE150E, PHE168C, PHE323C, PHE323E, PRO170C, PRO170E, SER177C, SER177E, SER182C, SER182E, SER251C, SER251E, SER319C, SER319E, SER320C, SER320E, SER329C, SER329E, SER330C, SER330E, SER98C, SER98E, THR115C, THR115E, THR117C, THR117E, THR175C, THR175E, THR255C, THR326C, THR326E, TYR103C, TYR103E, TYR114C, TYR114E, TYR179C, TYR179E, TYR254C, TYR254E, VAL143C, VAL143E, VAL149C, VAL149E, VAL172C, VAL172E, VAL99C, VAL99E
• C-M: ASN345C, LYS44M
• C-P: ALA61C, ALA61P, ASN59C, ASN59P, ASP60C, ASP60P, GLN62C, GLN62P, GLU232C, GLU232P, GLU233C, GLU233P, GLY57C, GLY57P, HIS213P, HIS63C, HIS63P, LEU208C, LEU208P, LEU346P, LYS56C, LYS56P, LYS58C, LYS58P, PRO209C, PRO209P, PRO231C, PRO231P, THR207C, THR211C, THR211P, TYR210C, TYR210P
• D-E: ALA260E, ALA26D, ALA270E, ALA304D, ALA304E, ALA50D, ALA75D, ARG156D, ARG272E, ARG303D, ARG303E, ARG45D, ASN218D, ASN219D, ASN24D, ASN46D, ASN47D, ASP164D, ASP262E, ASP289E, ASP307E, ASP71D, CYS259E, GLN62E, GLU107D, GLU161D, GLU232E, GLU233E, GLU236E, GLU277E, GLU348E, GLU79D, GLY111D, GLY163D, GLY23D, GLY265E, GLY305D, GLY305E, GLY49D, GLY74D, GLY92D, HIS268E, HIS310E, HIS63E, ILE230D, ILE258E, ILE290E, ILE347E, ILE52D, ILE91D, LEU245E, LEU346E, LEU88D, LYS112D, LYS261E, LYS273E, LYS27D, LYS280E, LYS287E, LYS309E, LYS44D, LYS48D, LYS78D, PHE165D, PHE306D, PHE306E, PRO21D, PRO266E, PRO292E, SER109D, SER110D, SER22D, SER263E, SER264E, SER87D, SER89D, THR108D, THR234E, THR25D, TRP96D, TYR267E, TYR269E, TYR286E, TYR291E, VAL162D, VAL235E, VAL276E, VAL288E, VAL308E, VAL77D
• D-F: ALA244D, ALA260D, ALA26F, ALA270D, ALA304D, ALA50F, ALA75F, ARG156F, ARG272D, ARG303D, ARG303F, ARG45F, ASN218F, ASN219F, ASN229F, ASN24F, ASN46F, ASN47F, ASP164F, ASP247D, ASP262D, ASP289D, ASP307D, ASP71F, CYS259D, GLN62D, GLU107F, GLU161F, GLU220F, GLU232D, GLU233D, GLU236D, GLU277D, GLU348D, GLU79F, GLY111F, GLY163F, GLY23F, GLY246D, GLY248D, GLY265D, GLY305D, GLY49F, GLY74F, GLY92F, HIS268D, HIS310D, HIS63D, ILE230F, ILE258D, ILE290D, ILE347D, ILE80F, ILE91F, LEU245D, LEU346D, LEU88F, LYS261D, LYS273D, LYS27F, LYS280D, LYS287D, LYS309D, LYS48F, LYS78F, PHE165F, PHE306D, PHE306F, PRO21F, PRO266D, PRO292D, SER109F, SER110F, SER228F, SER22F, SER263D, SER264D, SER87F, SER89F, THR108F, THR234D, THR25F, TRP96F, TYR237D, TYR267D, TYR269D, TYR286D, TYR291D, TYR293D, VAL162F, VAL235D, VAL276D, VAL288D, VAL308D, VAL77F
• D-H: ALA322D, ALA322H, ARG144D, ARG144H, ARG148D, ARG148H, ARG171D, ARG171H, ARG183D, ARG183H, ARG325D, ARG325H, ARG85D, ARG85H, ARG95D, ARG95H, ASN97D, ASN97H, ASP146D, ASP146H, ASP169D, ASP169H, ASP252D, ASP252H, ASP318D, ASP318H, CYS104D, CYS104H, GLN173D, GLN173H, GLU100D, GLU100H, GLU102D, GLU102H, GLU105D, GLU105H, GLU147D, GLU147H, GLU176D, GLU176H, GLU253D, GLU253H, GLU285D, GLU324D, GLU324H, GLU328D, GLU328H, GLY101D, GLY101H, GLY116D, GLY116H, GLY178D, GLY178H, GLY248D, HIS184D, HIS327D, HIS327H, HIS333D, ILE118D, ILE118H, ILE145D, ILE145H, ILE174H, ILE180D, ILE180H, ILE317D, ILE317H, LEU119D, LEU119H, LEU158D, LEU185D, LEU185H, LYS112D, LYS181D, LYS181H, PHE150D, PHE150H, PHE168H, PHE323D, PHE323H, PRO170D, PRO170H, SER177D, SER177H, SER182D, SER182H, SER319D, SER319H, SER320D, SER329D, SER329H, SER330D, SER330H, SER98D, SER98H, THR115D, THR115H, THR117D, THR117H, THR175D, THR175H, THR255D, THR326D, THR326H, TYR103D, TYR103H, TYR114D, TYR114H, TYR179D, TYR179H, TYR254D, TYR254H, VAL143D, VAL143H, VAL149D, VAL149H, VAL172D, VAL172H, VAL99D, VAL99H
• E-F: ALA260F, ALA26E, ALA270F, ALA304F, ALA50E, ALA75E, ARG156E, ARG272F, ARG303E, ARG303F, ARG45E, ASN218E, ASN219E, ASN24E, ASN46E, ASN47E, ASP164E, ASP247F, ASP262F, ASP289F, ASP307F, CYS259F, GLN62F, GLU107E, GLU161E, GLU221E, GLU232F, GLU233F, GLU236F, GLU277F, GLU348F, GLU79E, GLY111E, GLY163E, GLY23E, GLY246F, GLY248F, GLY265F, GLY305F, GLY49E, GLY74E, GLY92E, HIS268F, HIS310F, ILE106E, ILE230E, ILE258F, ILE290F, ILE347F, ILE52E, ILE91E, LEU245F, LEU346F, LEU88E, LYS261F, LYS273F, LYS27E, LYS280F, LYS287F, LYS309F, LYS48E, LYS78E, PHE165E, PHE306E, PHE306F, PRO21E, PRO266F, PRO292F, SER109E, SER110E, SER22E, SER263F, SER264F, SER87E, SER89E, THR108E, THR234F, THR25E, TRP96E, TYR267F, TYR269F, TYR286F, TYR291F, VAL162E, VAL235F, VAL276F, VAL288F, VAL308F, VAL77E
• F-L: ALA322F, ALA322L, ARG144F, ARG144L, ARG148F, ARG148L, ARG171F, ARG171L, ARG183F, ARG183L, ARG325F, ARG325L, ARG85F, ARG85L, ARG95F, ARG95L, ASN97F, ASN97L, ASP146F, ASP146L, ASP169F, ASP169L, ASP247L, ASP252F, ASP252L, ASP318F, ASP318L, CYS104F, CYS104L, GLN173F, GLN173L, GLU100F, GLU100L, GLU102F, GLU102L, GLU105F, GLU105L, GLU142F, GLU142L, GLU147F, GLU147L, GLU176F, GLU176L, GLU253F, GLU253L, GLU285F, GLU324F, GLU324L, GLU328F, GLU328L, GLY101F, GLY101L, GLY116F, GLY116L, GLY178F, GLY178L, GLY248F, GLY248L, HIS184F, HIS184L, HIS327F, HIS327L, HIS333F, HIS333L, ILE106F, ILE118F, ILE118L, ILE145F, ILE145L, ILE180F, ILE180L, ILE317F, ILE317L, LEU119F, LEU119L, LEU158F, LEU158L, LEU185F, LEU185L, LYS181F, LYS181L, PHE150F, PHE150L, PHE168F, PHE168L, PHE323F, PHE323L, PRO170F, PRO170L, SER177F, SER177L, SER182F, SER182L, SER319F, SER319L, SER320F, SER320L, SER329F, SER329L, SER330F, SER98F, SER98L, THR115F, THR115L, THR117F, THR117L, THR175F, THR175L, THR255F, THR326F, THR326L, TYR103F, TYR103L, TYR114F, TYR114L, TYR179F, TYR179L, TYR254F, TYR254L, VAL143F, VAL143L, VAL149F, VAL149L, VAL172F, VAL172L, VAL99F, VAL99L
• G-H: ALA260H, ALA26G, ALA270H, ALA304G, ALA304H, ALA50G, ALA75G, ARG156G, ARG272H, ARG303G, ARG303H, ARG45G, ASN218G, ASN219G, ASN24G, ASN46G, ASN47G, ASP164G, ASP262H, ASP289H, ASP307H, ASP71G, CYS259H, GLN62H, GLU107G, GLU161G, GLU221G, GLU232H, GLU233H, GLU236H, GLU277H, GLU348H, GLU79G, GLY111G, GLY163G, GLY23G, GLY265H, GLY305H, GLY49G, GLY74G, GLY92G, HIS268H, HIS310H, HIS63H, ILE222G, ILE230G, ILE258H, ILE290H, ILE347H, ILE52G, ILE91G, LEU346H, LEU88G, LYS261H, LYS273H, LYS27G, LYS280H, LYS287H, LYS309H, LYS48G, LYS78G, PHE165G, PHE306G, PHE306H, PHE94G, PRO21G, PRO266H, PRO292H, SER109G, SER110G, SER22G, SER263H, SER264H, SER87G, SER89G, THR108G, THR234H, THR25G, TRP96G, TYR267H, TYR269H, TYR286H, TYR291H, VAL162G, VAL235H, VAL276H, VAL288H, VAL308H, VAL77G
• G-I: ALA260G, ALA26I, ALA270G, ALA304G, ALA50I, ALA75I, ARG156I, ARG272G, ARG303G, ARG45I, ASN218I, ASN219I, ASN24I, ASN46I, ASN47I, ASP164I, ASP247G, ASP262G, ASP289G, ASP307G, CYS259G, GLN62G, GLU107I, GLU161I, GLU220I, GLU232G, GLU233G, GLU236G, GLU277G, GLU348G, GLU79I, GLY111I, GLY163I, GLY23I, GLY246G, GLY248G, GLY265G, GLY305G, GLY49I, GLY74I, GLY92I, HIS268G, HIS310G, HIS63G, ILE230I, ILE258G, ILE290G, ILE347G, ILE52I, ILE91I, LEU245G, LEU346G, LEU88I, LYS261G, LYS273G, LYS27I, LYS280G, LYS287G, LYS309G, LYS44I, LYS48I, LYS78I, LYS81I, PHE165I, PHE306G, PHE306I, PRO21I, PRO266G, PRO292G, SER109I, SER110I, SER22I, SER263G, SER264G, SER87I, SER89I, THR108I, THR234G, THR25I, TRP96I, TYR237G, TYR267G, TYR269G, TYR286G, TYR291G, TYR293G, VAL162I, VAL235G, VAL276G, VAL288G, VAL308G, VAL77I
• H-I: ALA260I, ALA26H, ALA270I, ALA50H, ALA75H, ARG156H, ARG272I, ARG45H, ASN218H, ASN219H, ASN229H, ASN24H, ASN46H, ASN47H, ASP164H, ASP262I, ASP289I, ASP307I, ASP71H, CYS259I, GLN62I, GLU107H, GLU161H, GLU220H, GLU232I, GLU233I, GLU236I, GLU277I, GLU348I, GLU79H, GLY111H, GLY163H, GLY23H, GLY265I, GLY49H, GLY74H, GLY92H, HIS268I, HIS310I, ILE230H, ILE258I, ILE290I, ILE347I, ILE52H, ILE91H, LEU245I, LEU346I, LEU88H, LYS112H, LYS261I, LYS273I, LYS27H, LYS280I, LYS287I, LYS309I, LYS48H, LYS78H, PHE165H, PHE306H, PHE306I, PRO21H, PRO266I, PRO292I, SER109H, SER110H, SER228H, SER22H, SER263I, SER264I, SER87H, SER89H, THR108H, THR234I, THR25H, TRP96H, TYR267I, TYR269I, TYR286I, TYR291I, VAL162H, VAL235I, VAL276I, VAL288I, VAL308I, VAL77H
• I-K: ALA322I, ALA322K, ARG144I, ARG144K, ARG148I, ARG148K, ARG171I, ARG171K, ARG183I, ARG183K, ARG325I, ARG325K, ARG85I, ARG85K, ARG95I, ARG95K, ASN97I, ASN97K, ASP146I, ASP146K, ASP169I, ASP169K, ASP252I, ASP252K, ASP318I, ASP318K, CYS104I, CYS104K, GLN173I, GLN173K, GLU100I, GLU100K, GLU102I, GLU102K, GLU105I, GLU105K, GLU142K, GLU147I, GLU147K, GLU176I, GLU176K, GLU253I, GLU253K, GLU285I, GLU285K, GLU324I, GLU324K, GLU328I, GLU328K, GLY101I, GLY101K, GLY116I, GLY116K, GLY178I, GLY178K, HIS184I, HIS184K, HIS327I, HIS327K, HIS333I, HIS333K, ILE118I, ILE118K, ILE145I, ILE145K, ILE174I, ILE180I, ILE180K, ILE317I, ILE317K, LEU119I, LEU119K, LEU185I, LEU185K, LYS181I, LYS181K, PHE150I, PHE150K, PHE168I, PHE323I, PHE323K, PRO170I, PRO170K, SER177I, SER177K, SER182I, SER182K, SER319I, SER319K, SER320I, SER320K, SER329I, SER329K, SER330I, SER330K, SER98I, SER98K, THR115I, THR115K, THR117I, THR117K, THR175I, THR175K, THR255I, THR255K, THR326I, THR326K, TRP96I, TYR103I, TYR103K, TYR114I, TYR114K, TYR179I, TYR179K, TYR254I, TYR254K, VAL143I, VAL143K, VAL149I, VAL149K, VAL172I, VAL172K, VAL99I, VAL99K
• J-K: ALA260K, ALA26J, ALA270K, ALA304K, ALA50J, ALA75J, ARG156J, ARG272K, ARG303J, ARG303K, ARG45J, ASN218J, ASN219J, ASN24J, ASN46J, ASN47J, ASP164J, ASP262K, ASP289K, ASP307K, ASP71J, CYS259K, GLN62K, GLU107J, GLU161J, GLU221J, GLU232K, GLU233K, GLU236K, GLU277K, GLU348K, GLU79J, GLY111J, GLY163J, GLY23J, GLY265K, GLY305K, GLY49J, GLY74J, GLY92J, HIS268K, HIS310K, HIS63K, ILE222J, ILE230J, ILE258K, ILE290K, ILE347K, ILE52J, ILE91J, LEU346K, LEU88J, LYS261K, LYS273K, LYS27J, LYS280K, LYS287K, LYS309K, LYS48J, LYS78J, PHE165J, PHE306J, PHE306K, PRO21J, PRO266K, PRO292K, SER109J, SER110J, SER22J, SER263K, SER264K, SER87J, SER89J, THR108J, THR234K, THR25J, TRP96J, TYR267K, TYR269K, TYR286K, TYR291K, VAL162J, VAL235K, VAL276K, VAL288K, VAL308K, VAL77J
• J-L: ALA250J, ALA260J, ALA26L, ALA270J, ALA304J, ALA50L, ALA75L, ARG156L, ARG272J, ARG303J, ARG303L, ARG45L, ASN218L, ASN219L, ASN229L, ASN24L, ASN46L, ASN47L, ASP164L, ASP262J, ASP289J, ASP307J, ASP71L, CYS259J, GLN62J, GLU107L, GLU161L, GLU220L, GLU232J, GLU233J, GLU236J, GLU277J, GLU348J, GLU79L, GLY111L, GLY163L, GLY23L, GLY265J, GLY305J, GLY49L, GLY74L, GLY92L, HIS268J, HIS310J, HIS63J, ILE230L, ILE258J, ILE290J, ILE347J, ILE52L, ILE91L, LEU346J, LEU88L, LYS112L, LYS261J, LYS273J, LYS27L, LYS280J, LYS287J, LYS309J, LYS44L, LYS48L, LYS78L, PHE165L, PHE306J, PHE306L, PHE94L, PRO21L, PRO266J, PRO292J, SER109L, SER110L, SER228L, SER22L, SER263J, SER264J, SER87L, SER89L, THR108L, THR234J, THR25L, TRP96L, TYR237J, TYR267J, TYR269J, TYR286J, TYR293J, VAL162L, VAL235J, VAL276J, VAL288J, VAL308J, VAL77L
• K-L: ALA260L, ALA26K, ALA270L, ALA304L, ALA50K, ALA75K, ARG156K, ARG272L, ARG303K, ARG303L, ARG45K, ASN218K, ASN219K, ASN229K, ASN24K, ASN46K, ASN47K, ASP164K, ASP247L, ASP262L, ASP289L, ASP307L, ASP71K, CYS259L, GLN62L, GLU107K, GLU161K, GLU232L, GLU233L, GLU236L, GLU277L, GLU348L, GLU79K, GLY111K, GLY163K, GLY23K, GLY246L, GLY248L, GLY265L, GLY305K, GLY305L, GLY49K, GLY74K, GLY92K, HIS268L, HIS310L, ILE258L, ILE290L, ILE347L, ILE52K, ILE80K, ILE91K, LEU245L, LEU346L, LEU88K, LYS261L, LYS273L, LYS27K, LYS280L, LYS287L, LYS309L, LYS48K, LYS78K, PHE165K, PHE306K, PHE306L, PRO21K, PRO266L, PRO292L, SER109K, SER110K, SER22K, SER263L, SER264L, SER87K, SER89K, THR108K, THR234L, THR25K, TRP96K, TYR267L, TYR269L, TYR286L, TYR291L, VAL162K, VAL235L, VAL276L, VAL288L, VAL308L, VAL77K
• M-N: ALA322N, ARG144M, ARG144N, ARG148M, ARG148N, ARG171M, ARG171N, ARG183M, ARG183N, ARG325M, ARG325N, ARG85M, ARG85N, ASN97M, ASN97N, ASP146M, ASP146N, ASP169M, ASP169N, ASP252M, ASP252N, ASP318M, ASP318N, CYS104M, CYS104N, GLN173M, GLN173N, GLU100M, GLU100N, GLU102M, GLU102N, GLU105M, GLU105N, GLU142N, GLU147M, GLU147N, GLU176M, GLU176N, GLU253M, GLU253N, GLU324M, GLU324N, GLU328M, GLU328N, GLY101M, GLY101N, GLY116M, GLY116N, GLY178M, GLY178N, GLY248M, HIS184M, HIS184N, HIS327M, HIS327N, HIS333M, HIS333N, ILE118M, ILE118N, ILE145M, ILE145N, ILE174N, ILE180M, ILE180N, ILE317M, ILE317N, LEU119M, LEU119N, LEU185M, LEU185N, LYS181M, LYS181N, PHE150M, PHE150N, PHE168N, PHE323M, PHE323N, PRO170M, PRO170N, SER177M, SER177N, SER182M, SER182N, SER251M, SER251N, SER319M, SER319N, SER320M, SER320N, SER329M, SER329N, SER330M, SER330N, SER98M, SER98N, THR115M, THR115N, THR117M, THR117N, THR175M, THR175N, THR326M, THR326N, TRP96N, TYR103M, TYR103N, TYR114M, TYR114N, TYR179M, TYR179N, TYR254M, TYR254N, VAL143M, VAL143N, VAL149M, VAL149N, VAL172M, VAL172N, VAL99M, VAL99N
• M-P: ALA260P, ALA26M, ALA270P, ALA304P, ALA50M, ALA75M, ARG156M, ARG272P, ARG303P, ARG45M, ASN218M, ASN219M, ASN229M, ASN24M, ASN46M, ASN47M, ASP164M, ASP247P, ASP262P, ASP289P, ASP307P, ASP71M, CYS259P, GLN62P, GLU107M, GLU161M, GLU221M, GLU232P, GLU233P, GLU236P, GLU277P, GLU348P, GLU79M, GLY111M, GLY163M, GLY23M, GLY246P, GLY248P, GLY265P, GLY305P, GLY49M, GLY74M, GLY92M, HIS268P, HIS310P, HIS63P, ILE222M, ILE230M, ILE258P, ILE290P, ILE347P, ILE52M, ILE91M, LEU245P, LEU346P, LEU88M, LYS261P, LYS273P, LYS27M, LYS280P, LYS287P, LYS309P, LYS48M, LYS78M, LYS81M, PHE165M, PHE306M, PHE306P, PRO21M, PRO266P, PRO292P, SER109M, SER110M, SER22M, SER263P, SER264P, SER87M, SER89M, THR108M, THR234P, THR25M, TRP96M, TYR267P, TYR269P, TYR286P, TYR291P, VAL162M, VAL235P, VAL276P, VAL288P, VAL308P, VAL77M
• O-P: ALA322O, ARG144O, ARG144P, ARG148O, ARG148P, ARG171O, ARG171P, ARG183O, ARG183P, ARG325O, ARG325P, ARG85O, ARG85P, ARG95O, ARG95P, ASN97O, ASN97P, ASP146O, ASP146P, ASP169O, ASP169P, ASP252O, ASP252P, ASP318O, ASP318P, CYS104O, CYS104P, GLN173O, GLN173P, GLU100O, GLU100P, GLU102O, GLU102P, GLU105O, GLU105P, GLU147O, GLU147P, GLU176O, GLU176P, GLU253O, GLU253P, GLU324O, GLU324P, GLU328O, GLU328P, GLY101O, GLY101P, GLY116O, GLY116P, GLY178O, GLY178P, GLY248O, GLY248P, HIS184P, HIS327O, HIS327P, ILE118O, ILE118P, ILE145O, ILE145P, ILE174O, ILE174P, ILE180O, ILE180P, ILE317O, ILE317P, LEU119O, LEU119P, LEU158O, LEU158P, LEU185O, LEU185P, LYS112P, LYS181O, LYS181P, PHE150O, PHE150P, PHE168O, PHE323O, PHE323P, PRO170O, PRO170P, SER177O, SER177P, SER182O, SER182P, SER319O, SER319P, SER320O, SER320P, SER329O, SER329P, SER330O, SER98O, SER98P, THR113P, THR115O, THR115P, THR117O, THR117P, THR175O, THR175P, THR326O, THR326P, TYR103O, TYR103P, TYR114O, TYR114P, TYR179O, TYR179P, TYR254O, TYR254P, VAL143O, VAL143P, VAL149O, VAL149P, VAL172O, VAL172P, VAL99O, VAL99P