2GPL

tmc-95 based biphenyl-ether macrocycles: specific proteasome inhibitors

• Total interactions analyzed: 378
• Total true interactions: 97
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 143
  • Norm. En. per Res.: -4.9691
• Hub Node: A(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-51.4227	-13.214	-407.717	-472.3537	136	22	7	15712	2	23	21
A-C	0.0	-10.0484	-17.8845	-27.9329	12	0	1	607	0	2	2
A-D	0.0	0.0	-1.5949	-1.5949	5	0	0	95	0	2	1
A-E	0.0	0.0	-4.4354	-4.4354	9	3	0	395	0	1	0
A-F	-6.9027	0.0	-24.9778	-31.8805	16	3	0	1044	0	0	2
A-G	-53.2246	-33.4213	-407.149	-493.7949	131	22	14	15679	2	22	26
A-H	-40.7303	-27.6439	-162.162	-230.5362	67	13	3	6246	4	17	17
A-I	-18.8155	-4.6292	-121.686	-145.1306	54	3	2	4873	2	16	20
B-C	-64.3378	18.6237	-510.646	-556.3602	145	47	9	18930	1	32	37
B-D	-6.8203	-16.5215	-21.4893	-44.8312	14	1	0	833	2	8	5
B-E	0.0	-10.1658	-21.1357	-31.3015	13	6	0	821	0	4	2
B-F	0.0	0.0	-23.157	-23.157	18	0	0	988	0	1	0
B-G	0.0	4.272	-35.6921	-31.4201	17	1	3	1168	0	2	5
B-H	0.0	14.1193	-1.2475	12.8717	9	0	0	94	0	5	4
B-I	-12.5097	-6.1991	-110.701	-129.4098	49	5	0	4699	0	16	18
B-J	-17.2438	-30.9072	-137.19	-185.341	48	14	2	4727	3	21	23
C-D	-75.2675	-39.9517	-395.394	-510.6133	120	26	9	14249	2	27	28
C-E	0.0	0.0	-0.0436	-0.0436	3	0	0	16	0	1	0
C-J	-13.1765	-13.4837	-84.134	-110.7941	42	5	2	3907	2	17	13
C-K	-29.5745	-35.7084	-55.8359	-121.1188	35	2	1	2457	8	29	23
D-E	-43.4244	-40.9481	-282.872	-367.2445	120	14	7	11698	2	34	36
D-G	0.0	0.0	-0.0031	-0.0031	2	0	0	3	0	0	0
D-K	-20.0345	-54.5423	-91.5565	-166.1333	51	6	1	4200	6	27	26
D-L	-10.0628	-36.3709	-137.563	-183.9967	51	2	0	4755	3	31	29
E-F	-67.632	-27.1121	-405.209	-499.9531	130	18	10	14871	2	30	34
E-G	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
E-L	-15.7473	-19.4547	-77.2047	-112.4067	40	5	0	3035	1	13	18
E-M	0.0	-21.7239	-147.721	-169.4449	53	2	3	5252	2	27	11
F-G	-87.218	-23.9249	-408.718	-519.8609	131	20	9	15258	4	26	27
F-M	-19.1789	-73.8408	-103.938	-196.9578	54	6	2	3860	6	32	22
F-N	-30.1535	-26.5594	-99.6966	-156.4095	49	3	2	4324	3	14	10
G-H	-28.3547	-75.0281	-176.414	-279.7968	60	7	1	6135	10	14	22
G-N	-6.4219	-39.5579	-82.7	-128.6798	48	0	4	3657	2	13	17
G-1	-2.8672	0.0	-11.8935	-14.7607	13	3	0	534	0	3	4
H-I	-152.4594	-160.3731	-397.745	-710.5775	143	24	14	15486	10	43	35
H-N	-31.5369	-40.8651	-92.7087	-165.1106	63	2	2	3609	3	15	4
H-Y	0.0	0.0	-10.9879	-10.9879	7	0	1	525	0	0	0
H-Z	-88.3383	-59.5827	-375.247	-523.168	113	28	5	14684	4	35	38
H-1	-3.9982	-39.0421	-208.087	-251.1273	92	7	5	9173	1	22	17
I-J	-11.6617	-56.2484	-114.849	-182.7591	76	7	4	5657	3	14	11
I-Y	-88.2334	-50.3171	-266.454	-405.0046	91	10	4	9842	5	20	20
I-Z	-33.2567	-35.0077	-187.781	-256.0454	72	11	1	7563	3	19	20
J-K	-47.794	-35.6187	-142.096	-225.5087	68	12	3	6050	3	21	21
J-X	-55.7694	-7.0278	-145.945	-208.7422	58	20	4	6672	1	16	30
J-Y	-36.4125	-44.1754	-207.216	-287.8039	75	15	1	7850	5	18	18
K-L	-60.6741	-32.1113	-172.956	-265.7414	81	9	4	6032	3	24	13
K-V	0.0	0.0	-10.2165	-10.2165	7	0	1	515	0	0	0
K-W	-93.3897	-50.5614	-271.269	-415.22	92	12	4	9976	5	20	20
K-X	-35.0666	-42.2996	-209.542	-286.9082	76	16	1	7937	5	19	18
L-M	-59.8203	6.0587	-232.657	-286.4185	91	10	5	9393	11	28	22
L-V	-83.4114	-60.0289	-388.557	-531.9973	114	29	5	14853	4	35	38
L-W	-31.72	-33.1372	-191.725	-256.5822	72	12	1	7618	3	19	20
M-N	-13.9922	-22.5018	-136.665	-173.159	66	3	1	5901	2	22	14
M-U	0.0	0.0	-11.677	-11.677	13	1	0	531	0	3	4
M-V	-6.96	-39.9299	-207.894	-254.7839	91	7	5	9161	1	22	18
M-2	-124.8892	24.1343	-390.58	-491.3349	112	17	10	14054	3	28	31
N-1	-125.3526	24.2874	-388.106	-489.1712	112	17	10	14017	3	28	31
N-2	-66.9636	-22.3309	-177.723	-267.0175	56	21	3	6879	4	10	11
O-P	-52.346	-14.5534	-432.667	-499.5664	135	27	7	16060	1	23	22
O-Q	0.0	-10.6554	-19.7786	-30.434	13	0	1	641	0	2	2
O-R	0.0	0.0	-2.2817	-2.2817	5	0	0	125	0	2	1
O-S	0.0	0.0	-4.8238	-4.8238	10	3	0	389	0	1	0
O-T	-7.4059	0.0	-24.4321	-31.838	16	4	0	1049	0	0	1
O-U	-65.6903	-32.2664	-456.632	-554.5887	132	27	14	16453	2	23	26
O-V	-39.6152	-27.5144	-159.548	-226.6776	67	11	3	6269	4	17	18
O-W	-17.1884	-1.5653	-121.603	-140.3567	54	2	2	4787	2	16	19
P-Q	-39.6519	9.4596	-419.32	-449.5124	135	20	6	16866	1	31	34
P-R	-6.0113	-17.1825	-25.3535	-48.5474	14	4	0	913	2	8	6
P-S	0.0	-9.8733	-22.425	-32.2983	13	3	0	762	0	4	2
P-T	0.0	0.0	-22.9988	-22.9988	18	0	0	998	0	1	0
P-U	0.0	4.4741	-39.6909	-35.2168	17	3	3	1246	0	2	5
P-V	0.0	14.0907	-1.4667	12.624	10	0	0	106	0	5	4
P-W	-3.2713	-6.3181	-108.693	-118.2824	50	4	0	4655	0	17	18
P-X	-12.3163	-31.062	-137.534	-180.9123	48	14	3	4747	3	21	23
Q-R	-76.6544	-40.4196	-378.576	-495.6501	120	25	9	14163	2	27	28
Q-S	0.0	0.0	-0.0262	-0.0262	2	0	0	14	0	1	0
Q-X	-11.097	-13.6884	-84.6476	-109.433	42	5	2	3850	2	17	13
Q-Y	-28.5457	-35.8941	-53.2987	-117.7385	34	1	1	2356	8	29	23
R-S	-76.7187	-50.6235	-334.324	-461.6662	123	32	7	12924	3	35	38
R-U	0.0	0.0	-0.0086	-0.0086	2	0	0	5	0	0	0
R-Y	-20.4343	-56.8495	-90.4116	-167.6954	50	9	1	4247	6	26	26
R-Z	-9.3185	-36.7717	-139.356	-185.4462	52	3	0	4844	3	31	30
S-T	-69.4797	-28.3026	-415.471	-513.2534	131	20	12	15052	2	31	34
S-Z	-16.6091	-20.5588	-85.224	-122.3919	43	7	0	3155	1	13	19
S-1	0.0	-21.4455	-146.054	-167.4995	53	3	3	5288	2	27	11
T-U	-81.0513	-23.5025	-403.472	-508.0258	132	23	9	15082	4	26	27
T-1	-19.425	-73.3534	-102.634	-195.4124	53	5	2	3858	6	32	22
T-2	-28.6006	-27.1725	-97.7443	-153.5174	48	3	2	4291	3	14	10
U-V	-26.7865	-74.5694	-172.643	-273.9989	59	7	1	6079	10	14	21
U-2	-3.4618	-37.479	-80.7032	-121.644	48	0	4	3592	2	13	17
V-W	-147.9449	-138.7953	-388.556	-675.2962	144	22	14	15404	10	43	35
V-2	-30.6944	-40.4096	-94.077	-165.181	63	2	2	3651	3	14	4
W-X	-11.0047	-56.7091	-112.985	-180.6989	74	6	4	5574	3	14	11
X-Y	-44.5619	-35.933	-141.036	-221.5309	68	12	3	6066	3	21	21
Y-Z	-61.7994	-27.9128	-181.322	-271.0342	82	9	4	6193	3	24	16
Z-1	-63.2076	4.9785	-233.432	-291.6611	91	13	5	9468	11	28	24
1-2	-12.3763	-22.0492	-137.377	-171.8024	65	3	1	5860	2	22	14

Interface residues

• A-B: ALA117A, ALA123A, ALA162A, ALA164A, ALA172A, ALA27B, ALA83B, ALA85B, ARG11B, ARG130B, ARG179A, ARG52B, ARG6B, ARG7A, ARG7B, ARG93B, ASN145A, ASN181A, ASN90B, ASP152A, ASP208B, ASP62B, ASP6A, ASP84B, ASP9B, GLN121A, GLN125A, GLN150A, GLN23A, GLN23B, GLN61B, GLU115A, GLU122A, GLU177A, GLU25B, GLU29B, GLU60B, GLU65B, GLU86B, GLY127A, GLY127B, GLY128A, GLY128B, GLY133B, GLY155A, GLY19A, GLY39A, GLY4B, GLY80B, HIS33B, ILE119A, ILE119B, ILE24A, ILE31B, ILE40A, ILE87B, LEU111A, LEU129B, LEU12A, LEU148A, LEU176A, LEU21A, LEU28B, LEU58B, LEU59B, LEU81B, LEU88B, LYS110A, LYS118A, LYS120B, LYS161A, LYS173A, LYS178A, LYS20A, LYS41A, MET120A, MET4A, PHE10A, PHE132B, PHE147A, PHE158A, PHE15A, PHE175A, PRO131A, PRO131B, PRO153A, PRO153B, PRO159A, PRO17A, SER10B, SER114A, SER11A, SER126A, SER14A, SER154A, SER156A, SER16A, SER18A, SER30B, SER32B, SER56B, SER5B, SER63B, SER9A, THR109A, THR124A, THR12B, THR13A, THR13B, THR14A, THR163A, THR174A, THR55B, THR57B, THR5A, THR63B, THR64B, THR82B, THR91B, TRP160A, TRP180A, TYR123B, TYR149A, TYR157A, TYR207B, TYR22B, TYR26B, TYR68B, TYR8A, TYR8B, VAL113A, VAL129A, VAL134B, VAL151A, VAL24B, VAL54B
• A-C: ARG10C, ARG7A, ASP6A, ASP9C, GLY127A, GLY7C, PHE10A, SER11A, SER9A, THR5A, TYR8A, TYR8C
• A-D: ALA12D, ARG7A, GLU12D, GLY12D, SER12D
• A-E: ARG7A, GLN125E, GLY128E, GLY129E, MET4A, PHE10A, SER126E, TYR127E, VAL13E
• A-F: ALA122F, ARG130F, ARG7A, ASN127F, ASP6A, HIS123F, LEU125F, MET4A, SER11F, SER128F, SER13F, THR5A, TYR126F, TYR8A, VAL129F, VAL14F
• A-G: ALA113G, ALA117G, ALA123A, ALA127G, ALA154G, ALA162G, ALA164G, ALA27A, ALA30A, ALA39G, ALA59A, ALA6G, ARG115G, ARG126G, ARG130A, ARG20G, ARG41G, ARG7A, ARG86A, ARG93A, ASN118G, ASN175G, ASN178G, ASP110G, ASP152G, ASP18G, ASP25A, ASP6A, ASP84A, ASP90A, ASP9G, GLN121G, GLN125G, GLN169G, GLN170G, GLN23A, GLN33A, GLU177G, GLU18G, GLU62A, GLY127A, GLY128A, GLY133A, GLY155G, GLY159G, GLY19G, GLY22A, GLY82A, HIS11G, HIS179G, ILE119A, ILE122G, ILE12G, ILE148G, ILE14G, ILE172G, ILE24A, LEU119G, LEU12A, LEU144G, LEU176G, LEU21G, LEU28A, LEU38G, LEU58A, LEU64A, LEU88A, LYS114G, LYS150G, LYS161G, LYS17G, LYS32A, LYS53A, LYS66A, LYS91A, MET116G, MET120A, MET129G, MET4A, MET60A, MET81A, PHE10A, PHE132A, PHE15G, PHE17G, PRO131A, PRO146G, PRO153A, PRO153G, PRO17G, PRO57A, PRO83A, SER120G, SER126A, SER147G, SER16G, SER54A, SER55A, SER56A, SER61A, SER65A, SER9A, THR124G, THR13A, THR13G, THR151G, THR163G, THR173G, THR174G, THR29A, THR5A, THR63A, TYR123G, TYR128G, TYR149G, TYR156G, TYR157G, TYR160G, TYR26A, TYR78A, TYR85A, TYR8A, TYR8G, VAL129A, VAL134A, VAL158G, VAL24G, VAL31A, VAL40G, VAL87A, VAL89A
• A-H: ALA184H, ALA96A, ARG102A, ARG189H, ARG36H, ARG86A, ARG93A, ASN62H, ASP183H, ASP21A, ASP90A, CYS176H, GLN57H, GLU185H, GLU64H, GLU73H, GLY104A, GLY21A, GLY60H, HIS35H, HIS66H, HIS97A, ILE21A, ILE37H, ILE41H, ILE59H, ILE63H, LEU187H, LEU21A, LEU34H, LEU58H, LEU65H, LEU68H, LEU69A, LEU70A, LYS101A, LYS182H, LYS40H, LYS91A, LYS94A, MET178H, MET82H, PRO21A, PRO39H, PRO72A, SER38H, SER61H, SER65A, SER67H, SER68A, SER71H, SER92A, THR21A, THR63A, THR70H, THR71A, THR98A, TRP42H, TYR106A, TYR186H, TYR21A, TYR69H, VAL175H, VAL177H, VAL87A, VAL89A, VAL95A
• A-I: ALA73I, ARG102A, ARG72I, ASN105I, ASN145A, ASP142A, GLN81I, GLU105A, GLU115A, GLU143A, GLU70I, GLU71I, GLU75I, GLU77I, GLU89I, GLY104A, GLY146A, HIS141A, HIS40I, ILE10A, ILE119I, ILE74I, LEU111A, LEU65I, LEU68I, LEU82I, LYS101A, LYS107I, LYS10I, LYS110A, LYS62I, LYS67I, LYS69I, PHE144A, PHE79I, PRO107A, PRO108A, PRO76I, SER10I, SER114A, SER84I, SER85I, SER86I, SER99A, THR21A, THR63I, THR78I, THR80I, TYR100A, TYR103A, TYR106A, TYR149A, TYR66I, VAL83I
• B-C: ALA11C, ALA162B, ALA172B, ALA27C, ALA30C, ALA42B, ALA83C, ARG10C, ARG114B, ARG115B, ARG11B, ARG130C, ARG144B, ARG20B, ARG33C, ARG53C, ARG62C, ARG6B, ARG7B, ARG86C, ARG93C, ASN152B, ASN156B, ASN82C, ASP118B, ASP142B, ASP179B, ASP182B, ASP60C, ASP84C, ASP9B, ASP9C, GLN120C, GLN121B, GLN125B, GLN147B, GLN173B, GLN177B, GLN23C, GLN59C, GLU110B, GLU18B, GLU25B, GLU25C, GLU29C, GLU90C, GLY122B, GLY127B, GLY127C, GLY128B, GLY128C, GLY133C, GLY140B, GLY145B, GLY155B, GLY159B, GLY19B, GLY39B, GLY7C, GLY80C, HIS126B, ILE119B, ILE14B, ILE14C, ILE163B, ILE40B, ILE46B, ILE62C, ILE87C, ILE89C, LEU116B, LEU129B, LEU12C, LEU148B, LEU175B, LEU176B, LEU192B, LEU21B, LEU28C, LEU56C, LEU58C, LEU81C, LEU88C, LYS120B, LYS161B, LYS181B, LYS32C, LYS57C, LYS66C, LYS91C, MET178B, MET41B, PHE132C, PHE15B, PHE22C, PHE78C, PRO131C, PRO153B, PRO153C, PRO17B, PRO64C, SER10B, SER117B, SER13C, SER151B, SER154B, SER164B, SER16B, SER170B, SER54C, SER5B, SER65C, SER85C, THR124B, THR12B, THR13B, THR150B, THR158B, THR169B, THR174B, THR55C, THR61C, THR63C, TRP160B, TYR123B, TYR123C, TYR138B, TYR141B, TYR146B, TYR149B, TYR14B, TYR157B, TYR180B, TYR22B, TYR26C, TYR8B, TYR8C, VAL109B, VAL113B, VAL119C, VAL129C, VAL134C, VAL24B, VAL24C, VAL31C
• B-D: ARG10D, ARG11B, ARG6B, ARG7B, ASP9B, ASP9D, GLU12D, GLY11D, GLY12D, SER13D, SER5B, THR14D, TYR8B, VAL12D
• B-E: ARG6B, ARG7B, ASN7E, ASP11E, ASP9B, GLY10E, GLY128E, GLY4B, SER5B, THR14E, TYR127E, TYR8B, VAL13E
• B-F: ARG6B, ARG7B, ASN127F, ASN12F, ASP9F, GLN23F, GLY4B, GLY7F, LEU10F, SER11F, SER128F, SER13F, SER5B, TYR126F, TYR8B, TYR8F, VAL129F, VAL14F
• B-G: ALA127G, ALA6G, ARG10G, ARG6B, ARG7B, ASP9B, ASP9G, GLN23G, GLY4B, GLY7G, HIS11G, ILE12G, ILE14G, SER5B, TYR128G, TYR8B, TYR8G
• B-H: ASN220H, ASP21B, ASP223H, ASP72B, CYS222H, GLU219B, LYS69B, TYR220B, VAL21B
• B-I: ALA92B, ALA96B, ARG60I, ARG93B, ASN104B, ASN56I, ASN64I, ASN71B, ASN90B, ASN98B, ASP106B, ASP72B, GLN221B, GLN97B, GLU105B, GLU57I, GLU70I, GLU71I, HIS95B, ILE223B, ILE74B, ILE89B, ILE94B, LEU100B, LEU55I, LEU65I, LEU68I, LEU70B, LYS101B, LYS62I, LYS67I, LYS69B, LYS69I, LYS73B, MET58I, PHE59I, SER63B, THR102B, THR53I, THR54I, THR63B, THR63I, THR64B, THR91B, TYR103B, TYR61I, TYR66I, TYR68B, TYR99B
• B-J: ALA78J, ALA88J, ARG114B, ARG144B, ARG69J, ARG84J, ASN104B, ASN62J, ASN98B, ASP105J, ASP106B, ASP118B, ASP142B, ASP143B, ASP71J, GLN77J, GLN85J, GLN97B, GLU105B, GLU110B, GLU70J, GLU73J, GLU86J, ILE107B, ILE111B, ILE63J, ILE68J, LEU100B, LEU74J, LYS101B, LYS10J, LYS119J, LYS89J, PHE82J, PRO108B, PRO76J, SER67J, SER75J, SER80J, SER81J, THR102B, TYR103B, TYR14B, TYR66J, TYR72J, TYR99B, VAL79J, VAL83J
• C-D: ALA117C, ALA11C, ALA162C, ALA30D, ALA54D, ALA83D, ALA85D, ARG10C, ARG10D, ARG114C, ARG122C, ARG126D, ARG130D, ARG173C, ARG18C, ARG86D, ARG93D, ASN179C, ASN20D, ASP18C, ASP62D, ASP84D, ASP9C, ASP9D, GLN120C, GLN121C, GLN125C, GLN150C, GLN163C, GLN23C, GLN23D, GLU110C, GLU12D, GLU145C, GLU152C, GLU174C, GLU177C, GLU25C, GLU25D, GLU29D, GLU60D, GLU65D, GLU90D, GLY118C, GLY11D, GLY127C, GLY128C, GLY12D, GLY133D, GLY155C, GLY19C, GLY39C, GLY80D, HIS20C, ILE14C, ILE156C, ILE21C, ILE31D, ILE64D, LEU127D, LEU12C, LEU148C, LEU176C, LEU192C, LEU28D, LEU33D, LEU58D, LEU59D, LEU81D, LYS147C, LYS178C, LYS32D, LYS41C, LYS66D, MET128D, MET88D, PHE123D, PHE132D, PHE15C, PHE175C, PHE22D, PRO131C, PRO131D, PRO146C, PRO153C, PRO153D, PRO17C, PRO57D, SER126C, SER129D, SER13C, SER154C, SER158C, SER159C, SER161C, SER16C, SER27D, SER56D, SER61D, SER63D, SER87D, THR124C, THR164C, THR55D, THR82D, TRP160C, TYR123C, TYR149C, TYR157C, TYR180C, TYR26D, TYR8C, VAL129C, VAL12D, VAL134D, VAL172C, VAL24C, VAL24D, VAL38C, VAL40C
• C-E: ARG10C, ASP9C, TYR127E
• C-J: ALA56J, ALA61J, ALA92C, ALA96C, ARG100C, ARG35J, ARG69J, ARG86C, ARG93C, ASN62J, ASP71C, ASP71J, GLN54J, GLN60J, GLN64J, GLN97C, GLU104C, GLU57J, GLU70J, GLU90C, GLU95C, HIS73C, ILE59J, ILE63J, ILE68J, ILE70C, ILE89C, LEU101C, LEU65J, LYS69C, LYS91C, PHE55J, SER67J, SER68C, SER72C, SER98C, THR102C, TYR58J, TYR66J, VAL53J, VAL74C, VAL94C
• C-K: ALA77K, ALA78K, ALA79K, ARG100C, ARG114C, ARG119K, ARG14C, ARG69K, ASN85K, ASP105C, GLU104C, GLU106K, GLU110C, GLU70K, GLU72K, HIS66K, HIS99C, ILE74K, ILE82K, LEU101C, LEU103C, LEU68K, LYS10K, LYS121K, LYS71K, LYS81K, SER75K, SER80K, SER98C, THR102C, THR108C, TYR111C, TYR111K, TYR157C, VAL76K
• D-E: ALA120D, ALA120E, ALA12D, ALA162D, ALA164D, ALA172D, ALA174D, ALA27E, ALA30E, ALA55E, ALA82E, ALA85E, ARG10D, ARG122D, ARG126D, ARG130E, ARG159D, ARG20D, ARG53E, ARG5E, ARG86E, ARG93E, ASN123E, ASN161D, ASN178D, ASN54E, ASN6E, ASN90E, ASP118D, ASP11E, ASP56E, ASP84E, ASP9D, ASP9E, CYS117D, GLN114D, GLN121E, GLN125E, GLN173D, GLN23E, GLN33E, GLN64E, GLU110D, GLU12D, GLU152D, GLU170D, GLU175D, GLU179D, GLU18D, GLU25D, GLU25E, GLU29E, GLU57E, GLY10E, GLY11D, GLY128E, GLY129E, GLY12D, GLY133E, GLY155D, GLY19D, GLY39D, GLY80E, HIS150D, HIS18D, ILE31E, ILE40D, ILE68E, LEU119D, LEU121D, LEU148D, LEU176D, LEU177D, LEU21D, LEU28E, LEU58E, LEU81E, LYS119E, LYS122E, LYS163D, LYS32E, LYS52E, LYS65E, LYS66E, PHE123D, PHE149D, PHE157D, PHE15D, PHE22D, PHE22E, PRO131E, PRO153D, PRO153E, PRO17D, PRO83E, SER111D, SER115D, SER126E, SER12D, SER13D, SER154D, SER16D, SER59E, SER60E, THR124E, THR12E, THR14D, THR156D, TRP180D, TYR127E, TYR132E, TYR158D, TYR160D, TYR26E, TYR63E, VAL12D, VAL134E, VAL24D, VAL24E, VAL87E
• D-G: ASP9D, TYR8G
• D-K: ALA92D, ALA95D, ALA96D, ARG64K, ARG69K, ARG72D, ARG86D, ARG93D, ASN100D, ASP104D, ASP62D, ASP71D, CYS63K, GLN53K, GLN62K, GLU56K, GLU65D, GLU67K, GLU69D, GLU70K, GLU90D, GLY220D, GLY60K, GLY75D, HIS66K, HIS73D, HIS91D, HIS99D, ILE223D, ILE64D, ILE67D, ILE70D, ILE74D, ILE89D, LEU101D, LEU59K, LEU65K, LEU68K, LYS71K, PHE221D, PHE54K, SER61K, SER63D, THR57K, THR94D, THR98D, TRP55K, TRP58K, TYR102D, VAL68D, VAL97D
• D-L: ALA143D, ALA79L, ALA80L, ALA95D, ALA96D, ARG81L, ASN100D, ASN108D, ASN70L, ASN77L, ASN82L, ASP104D, ASP106D, ASP142D, ASP144D, ASP14D, ASP69L, ASP71L, GLN114D, GLN147D, GLN84L, GLU105D, GLU106L, GLU110D, HIS70L, HIS85L, HIS99D, ILE107D, ILE83L, LEU101D, LEU112D, LEU74L, LYS72L, LYS73L, PHE59L, PHE68L, SER111D, SER115D, SER62L, SER75L, SER78L, THR98D, TRP65L, TYR102D, TYR103D, TYR111L, TYR119L, TYR66L, VAL109D, VAL63L, VAL97D
• E-F: ALA120E, ALA146E, ALA164E, ALA172E, ALA27F, ALA30F, ARG111E, ARG130F, ARG178E, ARG20E, ARG41E, ARG86F, ARG93F, ASN123E, ASN127F, ASN12F, ASN156E, ASN33F, ASN64F, ASN6E, ASN7E, ASN90F, ASP118E, ASP11E, ASP18E, ASP84F, ASP9E, ASP9F, CYS117E, GLN121E, GLN125E, GLN152E, GLN23F, GLN62F, GLN68F, GLU110E, GLU150E, GLU159E, GLU177E, GLU25F, GLU32F, GLY10E, GLY113E, GLY128E, GLY129E, GLY133F, GLY155E, GLY162E, GLY19E, GLY39E, GLY7F, GLY80F, GLY85F, HIS114E, HIS123F, HIS147E, HIS87F, ILE18E, ILE54F, ILE82F, LEU10F, LEU115E, LEU116E, LEU148E, LEU149E, LEU160E, LEU176E, LEU180E, LEU21E, LEU40E, LEU58F, LEU59F, LEU81F, LEU88F, LYS119E, LYS122E, LYS173E, LYS29F, LYS57F, LYS63F, LYS66F, PHE132F, PHE151E, PHE15E, PHE18E, PHE22F, PHE4E, PRO131F, PRO153E, PRO153F, PRO17E, PRO61F, PRO83F, SER11F, SER126E, SER128F, SER144E, SER154E, SER16E, SER56F, THR124E, THR12E, THR14E, THR158E, THR163E, THR174E, THR179E, THR18E, THR55F, THR6F, TYR119F, TYR126F, TYR127E, TYR161E, TYR175E, TYR26F, TYR8E, TYR8F, VAL120F, VAL129F, VAL134F, VAL13E, VAL157E, VAL24E, VAL24F, VAL28F, VAL31F, VAL38E, VAL60F, VAL65F
• E-G: ASN7E, TYR8G
• E-L: ARG58L, ARG86E, ARG93E, ASN104E, ASN61L, ASN70L, ASN90E, ASN97E, ASP69L, ASP71E, ASP71L, CYS70E, CYS96E, GLN94E, GLN95E, GLU72E, HIS67L, HIS70L, HIS73E, ILE223E, ILE68E, LEU101E, LEU92E, LYS106E, LYS57L, LYS60L, LYS64L, LYS65E, LYS69E, MET74E, PHE103E, PHE221E, PHE68L, SER100E, SER62L, SER89E, TRP65L, TYR91E, TYR98E, VAL102E
• E-M: ALA108E, ALA70M, ALA71M, ALA72M, ALA84M, ARG105E, ARG111E, ASN104E, ASN10M, ASN66M, ASN70M, ASP118E, ASP142E, ASP69M, GLN105M, GLN89M, GLU110E, GLU159E, GLU65M, GLU71M, GLU75M, GLU81M, GLY145E, HIS114E, HIS147E, ILE79M, LEU101E, LEU107E, LEU59M, LEU62M, LEU69M, LEU74M, LEU83M, LYS106E, LYS143E, PHE103E, PHE109M, PHE80M, PRO69M, PRO76M, SER100E, SER10M, SER144E, SER77M, SER99E, THR85M, TYR68M, TYR78M, TYR82M, TYR98E, VAL102E, VAL109E, VAL86M
• F-G: ALA113F, ALA122F, ALA127G, ALA146F, ALA163F, ALA164F, ALA172F, ALA174F, ALA27G, ALA30G, ALA85G, ALA88G, ALA89G, ARG10G, ARG115F, ARG130G, ARG169F, ARG20F, ARG86G, ARG91G, ASN127F, ASN12F, ASN21F, ASN32G, ASN87G, ASP114F, ASP18F, ASP56G, ASP60G, ASP84G, ASP9F, ASP9G, GLN118F, GLN121F, GLN170F, GLN23G, GLN33G, GLU152F, GLU175F, GLU177F, GLU211G, GLU25F, GLU25G, GLY117F, GLY133G, GLY155F, GLY159F, GLY162F, GLY19F, GLY39F, GLY5F, GLY7F, GLY7G, GLY80G, HIS11G, HIS123F, HIS147F, HIS18F, ILE12G, ILE38F, ILE40F, ILE67G, ILE82G, LEU10F, LEU125F, LEU132G, LEU148F, LEU151F, LEU176F, LEU179F, LEU58G, LEU59G, LEU90G, LYS161F, LYS173F, LYS178F, LYS29G, LYS41F, LYS52G, LYS57G, LYS93G, MET129G, MET150F, PHE138F, PHE15F, PHE28G, PHE68G, PRO110F, PRO131G, PRO153F, PRO153G, PRO17F, PRO55G, PRO61G, PRO81G, PRO83G, SER11F, SER128F, SER13F, SER154F, SER156F, SER16F, SER65G, THR124F, THR13G, THR31G, THR34G, THR62G, THR63G, THR6F, TRP158F, TYR119F, TYR123G, TYR126F, TYR128G, TYR149F, TYR157F, TYR160F, TYR22G, TYR26G, TYR66G, TYR8F, TYR8G, VAL120F, VAL134G, VAL14F, VAL180F, VAL24F, VAL24G, VAL54G, VAL64G
• F-M: ALA67M, ALA70M, ALA72M, ALA96F, ALA97F, ARG57M, ARG72F, ARG86F, ARG93F, ASN64F, ASN66M, ASN70M, ASN90F, ASP61M, ASP69M, ASP71F, ASP71M, GLN53M, GLN62F, GLN68F, GLU56M, GLU65M, GLU94F, GLY38M, GLY92F, HIS54M, HIS73F, ILE67F, ILE74F, LEU102F, LEU58M, LEU59M, LEU62M, LEU69M, LEU74M, LYS100F, LYS101F, LYS104F, LYS222F, LYS225F, LYS60M, LYS63F, LYS66F, PHE223F, PRO69M, SER98F, THR64M, TYR68M, VAL37M, VAL63M, VAL65F, VAL69F, VAL70F, VAL89F
• F-N: ALA111F, ALA79N, ALA80N, ARG115F, ASN106N, ASN144F, ASP105N, ASP114F, GLN118F, GLN69N, GLU77N, GLU85N, GLU89N, GLY72N, HIS62N, ILE107F, ILE58N, LEU102F, LEU63N, LEU65N, LEU86N, LYS100F, LYS101F, LYS104F, LYS10N, LYS121N, LYS143F, LYS84N, PHE112F, PHE83N, PHE99F, PRO106F, PRO108F, PRO110F, PRO74N, SER75N, SER81N, THR105F, THR73N, THR78N, TYR103F, TYR111N, TYR61N, TYR66N, TYR70N, TYR88N, VAL119N, VAL59N, VAL82N
• G-H: ALA113G, ALA117G, ALA79H, ARG100G, ARG115G, ARG72H, ARG75H, ASN118G, ASN62H, ASP105H, ASP106G, ASP110G, ASP142G, CYS109G, GLN81H, GLN85H, GLU143G, GLU14G, GLU73H, GLU98G, GLY104G, GLY145G, HIS66H, ILE59H, ILE63H, ILE74G, LEU112G, LEU119G, LEU144G, LEU65H, LEU68H, LEU80H, LEU83H, LYS102G, LYS114G, LYS84H, MET107G, MET116G, MET82H, PHE88H, PHE99G, PRO108G, PRO10H, PRO74H, SER140G, SER147G, SER67H, SER71H, SER78H, THR106H, THR70H, TYR101G, TYR103G, TYR105G, TYR149G, TYR157G, TYR69H, VAL111G, VAL76H, VAL77H
• G-N: ALA54N, ALA56N, ALA89G, ALA92G, ALA94G, ALA96G, ALA97G, ARG100G, ARG36N, ARG72G, ARG91G, ASP106G, ASP39N, ASP57N, CYS69G, GLN53N, GLN60N, GLN69N, GLU64N, GLU95G, GLU98G, GLY104G, GLY72N, HIS38N, HIS62N, ILE55N, ILE58N, ILE70G, LEU63N, LEU65N, LEU90G, LYS102G, LYS40N, LYS93G, MET107G, PHE68G, PHE99G, PRO74N, SER68N, SER71G, THR67N, THR73N, TYR101G, TYR105G, TYR61N, TYR66N, TYR70N, VAL59N
• G-1: ARG100G, ASP106G, ASP218G, GLN2091, GLU143G, GLY104G, GLY2071, LYS102G, LYS2101, THR2081, TYR101G, TYR103G, TYR105G
• H-I: ALA122I, ALA158I, ALA173I, ALA212H, ALA27H, ALA32H, ALA49H, ALA50H, ALA54H, ALA73I, ALA97H, ARG187I, ARG189H, ARG197H, ARG208H, ARG91I, ASN145I, ASN161I, ASN220H, ASN30H, ASP114I, ASP120I, ASP123I, ASP132I, ASP150I, ASP182I, ASP223H, ASP28H, ASP51H, CYS118I, CYS138I, CYS222H, CYS31H, GLN133I, GLN157I, GLN193I, GLN22H, GLN57H, GLN81I, GLU121I, GLU139I, GLU143I, GLU147I, GLU149I, GLU153I, GLU183I, GLU216H, GLU32I, GLU53H, GLY117I, GLY128I, GLY136I, GLY172I, GLY209H, GLY39I, GLY93H, GLY96H, HIS36I, HIS40I, HIS86H, HIS94H, ILE116I, ILE119I, ILE125I, ILE155I, ILE177I, ILE178I, ILE218H, ILE221H, ILE25H, ILE34I, ILE95H, LEU115I, LEU141I, LEU146I, LEU151I, LEU159I, LEU160I, LEU189I, LEU18I, LEU214H, LEU58H, LEU87I, LYS12I, LYS179I, LYS181I, LYS186I, LYS190I, LYS200H, LYS202H, LYS205H, LYS215H, LYS29H, LYS30I, LYS67I, MET137I, MET191I, MET6I, PHE113I, PHE124I, PHE135I, PHE152I, PHE206H, PHE42I, PHE92I, PRO144I, PRO148I, PRO207H, PRO24H, SER-5I, SER10I, SER127I, SER131I, SER140I, SER156I, SER203H, SER20H, SER217H, SER84I, SER85I, THR154I, THR210H, THR211H, THR21H, THR48H, THR52H, TYR142I, TYR176I, TYR188I, TYR204H, TYR38I, TYR88I, TYR90H, VAL126I, VAL174I, VAL175I, VAL184I, VAL185I, VAL213H, VAL219H, VAL26H, VAL41I, VAL55H
• H-N: ALA115H, ALA133H, ALA134H, ALA136H, ALA24N, ALA27N, ALA49N, ALA50N, ALA54N, ALA56N, ARG174N, ARG29N, ARG45N, ASN28N, ASN90N, ASN94N, ASP120H, ASP32N, ASP51N, ASP57N, GLN53N, GLN60N, GLN81H, GLN85H, GLN91H, GLU139H, GLY117H, GLY122H, HIS114H, HIS116H, ILE113H, ILE26N, ILE55N, ILE58N, LEU125H, LEU127H, LEU132H, LEU138H, LEU80H, LEU87H, LEU95N, LYS84H, MET135H, PHE88H, SER112H, SER118H, SER126H, SER131H, SER48N, THR119H, THR20N, THR22N, THR31N, THR52N, THR96N, TRP142H, TYR123H, TYR124H, TYR25N, TYR61N, TYR98H, VAL121H, VAL30N
• H-Y: GLY211Y, ILE210Y, LEU214H, LYS200Y, LYS215H, TRP197Y, VAL209Y
• H-Z: ALA129Z, ALA130Z, ALA133H, ALA161H, ALA162Z, ALA212H, ALA27H, ARG156Z, ARG165Z, ARG193Z, ARG197H, ARG19H, ARG19Z, ARG208H, ARG29Z, ASN140Z, ASN14Z, ASN165H, ASN172H, ASN195H, ASN1Z, ASN20Z, ASN27Z, ASN30H, ASP157Z, ASP166H, ASP171Z, ASP17H, ASP194Z, ASP23Z, ASP28H, GLN141Z, GLN14Z, GLN160H, GLN168Z, GLN201H, GLN22H, GLU149Z, GLU14Z, GLU150Z, GLU164Z, GLU190Z, GLU198H, GLU199H, GLY-1Z, GLY130H, GLY14Z, GLY162H, GLY168H, GLY170H, GLY170Z, GLY1Z, GLY209H, GLY23H, HIS166Z, ILE152Z, ILE163H, ILE167Z, ILE21Z, ILE25H, ILE26Z, LEU133Z, LEU138Z, LEU146Z, LEU154Z, LEU167H, LEU191Z, LEU214H, LYS14Z, LYS153Z, LYS192Z, LYS200H, LYS202H, LYS205H, LYS29H, PHE137Z, PHE144Z, PHE159Z, PHE206H, PRO14Z, PRO194H, PRO207H, PRO24H, SER129H, SER132Z, SER158Z, SER161Z, SER169H, SER171H, SER203H, SER20H, SER25Z, THR14Z, THR160Z, THR163Z, THR18H, THR1H, THR210H, THR211H, THR21H, THR22Z, TRP164H, TYR14Z, TYR189Z, TYR204H, TYR24Z, VAL14Z, VAL151Z, VAL155Z, VAL169Z, VAL196H, VAL213H, VAL26H
• H-1: ALA1311, ALA133H, ALA1341, ALA134H, ALA136H, ALA1581, ALA158H, ALA161H, ALA2001, ARG1391, ARG1601, ARG1651, ARG75H, ASN1351, ASN1571, ASN165H, ASP120H, ASP141, ASP145H, ASP157H, ASP1661, ASP166H, ASP1981, ASP2021, GLN144H, GLN160H, GLN2091, GLN81H, GLN85H, GLU139H, GLY117H, GLY122H, GLY1281, GLY1301, GLY130H, GLY162H, GLY2051, GLY2071, HIS109H, HIS1321, HIS141H, ILE113H, ILE2031, LEU110H, LEU125H, LEU132H, LEU1371, LEU1381, LEU138H, LEU146H, LEU154H, LEU1621, LEU167H, LEU80H, LYS1401, LYS143H, LYS153H, LYS1961, LYS2011, LYS2041, LYS2101, LYS7H, LYS84H, MET1331, MET135H, PHE111H, PHE1291, PHE1991, PRO1361, SER112H, SER118H, SER126H, SER129H, SER131H, SER140H, SER78H, THR106H, THR119H, THR1241, THR2081, TRP142H, TRP164H, TRP1971, TYR123H, TYR124H, TYR1641, TYR2061, VAL121H, VAL137H, VAL1611, VAL76H, VAL77H
• I-J: ALA126J, ALA49I, ALA88J, ARG60I, ARG7J, ARG84J, ARG90I, ARG90J, ASN-2I, ASN29I, ASN56I, ASP114J, ASP139J, ASP51I, GLN112J, GLN23I, GLN77J, GLN85J, GLU121J, GLU32I, GLU57I, GLY117J, GLY125J, GLY128J, GLY131J, GLY21I, GLY26I, GLY93I, HIS127J, ILE-3I, ILE113J, ILE90J, LEU115I, LEU116J, LEU122J, LEU18I, LEU20I, LEU25I, LEU48I, LEU55I, LEU87J, LYS119J, LYS30I, LYS89J, MET58I, PHE132J, PHE135J, PHE31I, PHE92I, PHE96I, PRO-6I, PRO123J, PRO94I, SER-8I, SER130J, SER136J, SER22I, SER24I, SER28I, SER81J, THR118J, THR134J, THR50I, THR53I, THR54I, TRP171I, TYR115J, TYR124J, TYR129J, TYR133J, TYR61I, TYR95I, VAL120J, VAL27I, VAL52I, VAL97I
• I-Y: ALA130I, ALA161Y, ALA162I, ALA162Y, ALA163I, ALA163Y, ALA167I, ALA167Y, ALA20Y, ALA22Y, ALA27Y, ARG165I, ARG165Y, ARG192I, ARG19I, ARG19Y, ASN161I, ASN207Y, ASN208Y, ASN24Y, ASN29I, ASP-7I, ASP132I, ASP164I, ASP166I, ASP166Y, ASP17Y, ASP191Y, ASP194I, GLN133I, GLN193I, GLN23I, GLN29Y, GLU194Y, GLU201Y, GLY-1I, GLY130Y, GLY170Y, GLY171Y, GLY172I, GLY193Y, GLY1I, GLY211Y, GLY21I, GLY23Y, GLY26I, HIS164Y, HIS190Y, ILE-3I, ILE159Y, ILE210Y, LEU160Y, LEU168I, LEU189I, LEU18I, LEU195Y, LEU20I, LEU25I, LYS190I, LYS198Y, LYS200Y, LYS30I, MET191I, PHE133Y, PHE196Y, PHE206Y, SER-4I, SER-5I, SER129Y, SER169I, SER169Y, SER172Y, SER18Y, SER22I, SER24I, SER28I, SER28Y, THR129I, THR132Y, THR21Y, THR30Y, TRP171I, TRP197Y, TRP25Y, TYR168Y, TYR188I, VAL173Y, VAL192Y, VAL209Y, VAL26Y, VAL27I
• I-Z: ALA122I, ALA126Z, ALA129Z, ALA130I, ALA130Z, ALA131Z, ALA158I, ALA162I, ALA162Z, ALA163I, ARG125Z, ARG165I, ARG165Z, ARG192I, ASN140Z, ASN143Z, ASN14Z, ASN161I, ASN1Z, ASP120I, ASP123I, ASP132I, ASP139Z, ASP157Z, ASP164I, ASP166I, CYS124Z, CYS138I, GLN133I, GLN141Z, GLN14Z, GLN157I, GLU139I, GLU153I, GLU164Z, GLY136I, GLY14Z, HIS166Z, ILE125I, ILE134Z, LEU133Z, LEU134I, LEU138Z, LEU141I, LEU154Z, LEU159I, LEU160I, LEU189I, LYS12I, LYS14Z, LYS190I, MET135Z, MET137I, MET191I, PHE124I, PHE135I, PHE137Z, PHE144Z, PHE159Z, PRO136Z, PRO14Z, SER131I, SER132Z, SER140I, SER156I, SER158Z, SER161Z, THR160Z, THR163Z, TYR142I, TYR14Z, VAL126I
• J-K: ALA49J, ALA93K, ARG119K, ARG22J, ARG35J, ARG92J, ARG93J, ASN85K, ASP114K, ASP116K, ASP123K, ASP29J, ASP31J, ASP32J, ASP51J, CYS126K, GLN131K, GLN54J, GLN60J, GLN89K, GLN96J, GLU48J, GLU57J, GLY117K, GLY122K, GLY128K, GLY23J, GLY50J, GLY92K, ILE110K, ILE124K, ILE24J, LEU120K, LEU27J, LEU86K, LYS121K, LYS28J, LYS33J, LYS81K, LYS91K, MET100K, PHE125K, PHE133K, PHE55J, PRO94J, SER115K, SER129K, SER25J, SER30J, SER84K, THR118K, THR132K, THR21J, THR52J, TYR111K, TYR112K, TYR135K, TYR58J, TYR88K, TYR90K, TYR95J, VAL113K, VAL127K, VAL20J, VAL26J, VAL53J, VAL87K, VAL97J
• J-X: ALA19J, ALA19X, ARG165J, ARG165X, ARG22J, ARG22X, ASP169J, ASP169X, ASP29J, ASP29X, GLN160J, GLN160X, GLU161J, GLU161X, GLU163J, GLU163X, GLY128J, GLY128X, GLY131J, GLY131X, GLY23J, GLY23X, ILE24J, ILE24X, LEU162J, LEU162X, LEU27J, LEU27X, LYS164J, LYS164X, LYS171J, LYS171X, LYS28J, LYS28X, MET166J, MET166X, MET168J, MET168X, PHE132J, PHE132X, PHE170J, PHE170X, PRO167J, PRO167X, SER130J, SER130X, SER25J, SER25X, THR21J, THR21X, TYR129J, TYR129X, TYR133J, TYR133X, VAL20J, VAL20X, VAL26J, VAL26X
• J-Y: ALA126J, ALA134Y, ALA161Y, ALA162Y, ALA167Y, ARG143J, ARG157Y, ARG165J, ARG165Y, ARG7J, ASN141Y, ASN207Y, ASN208Y, ASP123Y, ASP139J, ASP139Y, ASP145J, ASP166Y, CYS126Y, CYS158J, GLN112J, GLN131Y, GLN160J, GLU121J, GLU161J, GLU203Y, GLY125J, GLY130Y, GLY131J, GLY136Y, GLY204Y, HIS140J, HIS141J, HIS164Y, ILE124Y, LEU122J, LEU137J, LEU138J, LEU138Y, LEU154Y, LEU157J, LEU160Y, LEU162J, LYS164J, LYS200Y, MET146J, MET166J, PHE125Y, PHE132J, PHE133Y, PHE135J, PHE196Y, PHE206Y, PRO123J, PRO144J, PRO167J, SER129Y, SER130J, SER136J, SER140Y, SER158Y, SER205Y, THR132Y, THR134J, TYR124J, TYR129J, TYR133J, TYR135Y, TYR142J, TYR142Y, TYR153Y, TYR168Y, VAL137Y, VAL199Y, VAL209Y
• K-L: ALA126L, ALA130L, ALA131L, ALA20K, ALA22K, ALA27K, ALA49K, ALA50K, ALA93K, ARG121L, ARG125L, ARG81L, ARG91L, ASN143L, ASN82L, ASP114L, ASP139L, ASP191K, ASP51K, CYS124L, CYS52K, GLN123L, GLN29K, GLN53K, GLN84L, GLU120L, GLU122L, GLU194K, GLU201K, GLU56K, GLY117L, GLY127L, GLY193K, GLY211K, GLY48K, GLY89L, GLY92K, GLY94K, HIS85L, HIS98L, ILE134L, ILE35K, LEU133L, LEU86K, LEU86L, LEU87L, LEU95K, LYS14L, LYS32K, LYS33K, MET135L, MET45K, MET97K, PHE113L, PHE137L, PHE54K, PHE92L, PRO115L, PRO136L, SER112L, SER115K, SER118L, SER132L, SER18K, SER28K, SER61K, SER96K, THR30K, THR57K, TRP197K, TRP25K, TRP55K, TRP58K, TYR119L, TYR14L, TYR88L, TYR90K, VAL116L, VAL26K, VAL31K, VAL34K
• K-V: GLY211K, ILE210K, LEU214V, LYS200K, LYS215V, TRP197K, VAL209K
• K-W: ALA130W, ALA161K, ALA162K, ALA162W, ALA163K, ALA163W, ALA167K, ALA167W, ALA20K, ALA22K, ALA27K, ARG165K, ARG165W, ARG192W, ARG19K, ARG19W, ASN161W, ASN207K, ASN208K, ASN24K, ASN29W, ASP-7W, ASP132W, ASP164W, ASP166K, ASP166W, ASP17K, ASP191K, ASP194W, GLN133W, GLN193W, GLN23W, GLN29K, GLU194K, GLU201K, GLY-1W, GLY130K, GLY170K, GLY171K, GLY172W, GLY193K, GLY1W, GLY211K, GLY21W, GLY23K, GLY26W, HIS164K, HIS190K, ILE-3W, ILE159K, ILE210K, LEU160K, LEU168W, LEU189W, LEU18W, LEU195K, LEU20W, LEU25W, LYS190W, LYS198K, LYS200K, LYS30W, MET191W, PHE133K, PHE196K, PHE206K, SER-4W, SER-5W, SER129K, SER169K, SER169W, SER172K, SER18K, SER22W, SER24W, SER28K, SER28W, THR129W, THR132K, THR1K, THR21K, THR30K, TRP171W, TRP197K, TRP25K, TYR168K, TYR188W, VAL173K, VAL192K, VAL209K, VAL26K, VAL27W
• K-X: ALA126X, ALA134K, ALA161K, ALA162K, ALA167K, ARG143X, ARG157K, ARG165K, ARG165X, ARG7X, ASN141K, ASN207K, ASN208K, ASP123K, ASP139K, ASP139X, ASP145X, ASP166K, CYS126K, CYS158X, GLN112X, GLN131K, GLN160X, GLU121X, GLU161X, GLU203K, GLY125X, GLY130K, GLY131X, GLY136K, GLY204K, HIS140X, HIS141X, HIS164K, ILE124K, LEU122X, LEU137X, LEU138K, LEU138X, LEU154K, LEU157X, LEU160K, LEU162X, LYS164X, LYS200K, MET146X, MET166X, PHE125K, PHE132X, PHE133K, PHE135X, PHE196K, PHE206K, PHE6K, PRO123X, PRO144X, PRO167X, SER129K, SER130X, SER136X, SER140K, SER158K, SER205K, THR132K, THR134X, TYR124X, TYR129X, TYR133X, TYR135K, TYR142K, TYR142X, TYR153K, TYR168K, VAL137K, VAL199K, VAL209K
• L-M: ALA126M, ALA131M, ALA49L, ALA50L, ALA54L, ALA84M, ARG111M, ARG139M, ARG14M, ARG193L, ARG19L, ARG29L, ARG58L, ARG90M, ARG91M, ASN-2L, ASN-7L, ASN114M, ASN135M, ASN20L, ASN27L, ASN93M, ASP-3L, ASP14M, ASP171L, ASP23L, ASP51L, ASP53L, GLN-6M, GLN-7M, GLN-9L, GLN89M, GLU14M, GLU190L, GLU31L, GLU81M, GLY-4L, GLY117M, GLY128M, GLY52L, HIS132M, ILE21L, ILE26L, LEU115M, LEU116M, LEU125M, LEU191L, LEU55L, LEU95M, LYS57L, LYS90L, LYS92M, MET87M, MET92M, PHE-8L, PHE188L, PHE35L, PHE48L, PHE80M, PHE93L, PRO-5M, PRO-6L, PRO123M, PRO136M, PRO32L, PRO94L, PRO94M, SER121M, SER122M, SER25L, SER28L, SER92M, THR-8M, THR119M, THR124M, THR22L, THR85M, TRP96M, TYR-5L, TYR112M, TYR120M, TYR24L, TYR30L, TYR82M, TYR88M, TYR95L, TYR96L, VAL113M, VAL118M, VAL14M, VAL97L
• L-V: ALA129L, ALA130L, ALA133V, ALA161V, ALA162L, ALA212V, ALA27V, ARG156L, ARG165L, ARG193L, ARG197V, ARG19L, ARG19V, ARG208V, ARG29L, ASN140L, ASN14L, ASN165V, ASN172V, ASN195V, ASN1L, ASN20L, ASN27L, ASN30V, ASP157L, ASP166V, ASP171L, ASP17V, ASP194L, ASP23L, ASP28V, GLN141L, GLN14L, GLN160V, GLN168L, GLN201V, GLN22V, GLU149L, GLU14L, GLU150L, GLU164L, GLU190L, GLU198V, GLU199V, GLY-1L, GLY130V, GLY14L, GLY162V, GLY168V, GLY170L, GLY170V, GLY1L, GLY209V, GLY23V, HIS166L, ILE152L, ILE163V, ILE167L, ILE21L, ILE25V, ILE26L, LEU133L, LEU138L, LEU146L, LEU154L, LEU167V, LEU191L, LEU214V, LYS14L, LYS153L, LYS192L, LYS200V, LYS202V, LYS205V, LYS29V, PHE137L, PHE144L, PHE159L, PHE206V, PRO14L, PRO194V, PRO207V, PRO24V, SER129V, SER132L, SER158L, SER161L, SER169V, SER171V, SER203V, SER20V, SER25L, THR14L, THR160L, THR163L, THR18V, THR1V, THR210V, THR211V, THR21V, THR22L, TRP164V, TYR14L, TYR189L, TYR204V, TYR24L, VAL142L, VAL14L, VAL151L, VAL155L, VAL169L, VAL196V, VAL213V, VAL26V
• L-W: ALA122W, ALA126L, ALA129L, ALA130L, ALA130W, ALA131L, ALA158W, ALA162L, ALA162W, ALA163W, ARG125L, ARG165L, ARG165W, ARG192W, ASN140L, ASN143L, ASN14L, ASN161W, ASN1L, ASP120W, ASP123W, ASP132W, ASP139L, ASP157L, ASP164W, ASP166W, CYS124L, CYS138W, GLN133W, GLN141L, GLN14L, GLN157W, GLU139W, GLU153W, GLU164L, GLY136W, GLY14L, HIS166L, ILE125W, ILE134L, LEU133L, LEU134W, LEU138L, LEU141W, LEU154L, LEU159W, LEU160W, LEU189W, LYS12W, LYS14L, LYS190W, MET135L, MET137W, MET191W, PHE124W, PHE135W, PHE137L, PHE144L, PHE159L, PRO136L, PRO14L, SER131W, SER132L, SER140W, SER156W, SER158L, SER161L, THR160L, THR163L, TYR142W, TYR14L, VAL126W
• M-N: ALA125N, ALA127N, ARG27M, ARG57M, ARG90M, ASN29M, ASN93M, ASN97M, ASP48M, ASP51M, ASP92N, CYS87N, GLN-6M, GLN-7M, GLN53M, GLU56M, GLU85N, GLU89N, GLY116N, GLY117N, GLY128N, GLY20M, GLY30M, GLY98N, HIS120N, HIS54M, ILE-4M, ILE100N, ILE113N, ILE126N, ILE3N, ILE49M, ILE55M, ILE99N, LEU115N, LEU122N, LEU25M, LEU26M, LEU58M, LEU95M, LYS121N, LYS84N, LYS91N, MET52M, MET92M, PHE28M, PRO-5M, PRO114N, PRO94M, SER118N, SER131N, SER46N, SER50M, SER81N, THR-2M, THR-8M, THR112N, THR132N, TRP96M, TYR124N, TYR135N, TYR22M, TYR88N, VAL-3M, VAL119N, VAL31M
• M-U: ARG100U, ASP106U, ASP218U, GLN209M, GLU143U, GLY104U, GLY207M, LYS102U, LYS210M, THR208M, TYR101U, TYR103U, TYR105U
• M-V: ALA131M, ALA133V, ALA134M, ALA134V, ALA136V, ALA158M, ALA158V, ALA161V, ALA200M, ARG139M, ARG160M, ARG165M, ARG75V, ASN135M, ASN157M, ASN165V, ASP120V, ASP14M, ASP157V, ASP166M, ASP166V, ASP198M, ASP202M, GLN144V, GLN160V, GLN209M, GLN81V, GLN85V, GLU139V, GLY117V, GLY122V, GLY128M, GLY130M, GLY130V, GLY162V, GLY205M, GLY207M, HIS109V, HIS132M, HIS141V, ILE113V, ILE203M, LEU110V, LEU125V, LEU132V, LEU137M, LEU138M, LEU138V, LEU146V, LEU154V, LEU162M, LEU167V, LEU80V, LYS140M, LYS143V, LYS153V, LYS196M, LYS201M, LYS204M, LYS210M, LYS7V, LYS84V, MET133M, MET135V, PHE111V, PHE129M, PHE199M, PRO136M, SER112V, SER118V, SER126V, SER129V, SER131V, SER140V, SER78V, THR106V, THR119V, THR124M, THR208M, TRP142V, TRP164V, TRP197M, TYR123V, TYR124V, TYR164M, TYR206M, VAL121V, VAL137V, VAL161M, VAL76V, VAL77V
• M-2: ALA1622, ALA167M, ALA200M, ALA242, ALA272, ALA492, ALA542, ALA562, ARG160M, ARG165M, ARG168M, ARG171M, ARG1742, ARG1862, ARG192, ARG27M, ARG292, ARG362, ARG452, ASN194M, ASN282, ASN29M, ASP1662, ASP166M, ASP182, ASP198M, ASP202M, ASP322, ASP392, ASP572, CYS432, GLN1612, GLN182, GLN191M, GLN209M, GLN532, GLN602, GLU182, GLU1852, GLU193M, GLY1302, GLY1672, GLY1702, GLY1712, GLY205M, GLY207M, GLY232, GLY23M, HIS132M, HIS382, ILE1632, ILE182, ILE203M, ILE211M, ILE262, ILE412, ILE552, ILE582, LEU162M, LEU1782, LEU1872, LEU19M, LEU25M, LEU26M, LEU342, LYS1642, LYS196M, LYS201M, LYS204M, LYS210M, LYS332, LYS402, MET133M, MET195M, PHE129M, PHE1332, PHE182, PHE199M, PHE28M, PRO182, SER1292, SER1682, SER1692, SER169M, SER182, SER21M, SER24M, THR1322, THR1M, THR202, THR208M, THR212, THR222, THR312, THR352, THR522, TRP1652, TRP197M, TRP422, TYR163M, TYR164M, TYR182, TYR206M, TYR22M, TYR252, VAL161M, VAL1722, VAL1762, VAL1842, VAL192M, VAL302, VAL372
• N-1: ALA162N, ALA1671, ALA2001, ALA24N, ALA27N, ALA49N, ALA54N, ALA56N, ARG1601, ARG1651, ARG1681, ARG1711, ARG174N, ARG186N, ARG19N, ARG271, ARG29N, ARG36N, ARG45N, ASN1941, ASN28N, ASN291, ASP1661, ASP166N, ASP18N, ASP1981, ASP2021, ASP32N, ASP39N, ASP57N, CYS43N, GLN161N, GLN18N, GLN1911, GLN2091, GLN53N, GLN60N, GLU185N, GLU18N, GLU1931, GLY130N, GLY167N, GLY170N, GLY171N, GLY2051, GLY2071, GLY231, GLY23N, HIS1321, HIS38N, ILE163N, ILE18N, ILE2031, ILE2111, ILE26N, ILE41N, ILE55N, ILE58N, LEU1621, LEU178N, LEU187N, LEU191, LEU251, LEU261, LEU34N, LYS164N, LYS1961, LYS2011, LYS2041, LYS2101, LYS33N, LYS40N, MET1331, MET1951, PHE1291, PHE133N, PHE18N, PHE1991, PHE281, PRO18N, SER129N, SER168N, SER1691, SER169N, SER18N, SER211, SER241, THR11, THR132N, THR2081, THR20N, THR21N, THR22N, THR31N, THR35N, THR52N, TRP165N, TRP1971, TRP42N, TYR1631, TYR1641, TYR18N, TYR2061, TYR221, TYR25N, VAL1611, VAL172N, VAL176N, VAL184N, VAL1921, VAL30N, VAL37N
• N-2: ALA1622, ALA162N, ASN1412, ASN141N, ASP1392, ASP139N, ASP1532, ASP153N, CYS1382, CYS138N, GLN1612, GLN161N, GLN182, GLN18N, GLY1302, GLY130N, GLY1362, GLY136N, HIS1572, HIS157N, ILE1262, ILE126N, ILE1342, ILE134N, LEU1222, LEU122N, LEU182, LEU18N, LYS1402, LYS140N, LYS1562, LYS156N, LYS1642, LYS164N, PHE1332, PHE133N, PHE1542, PHE154N, SER1312, SER131N, SER1582, SER158N, SER1602, SER160N, THR1322, THR132N, TRP1652, TRP165N, TYR1242, TYR124N, TYR1352, TYR135N, TYR1372, TYR137N, TYR182, TYR18N
• O-P: ALA117O, ALA123O, ALA162O, ALA164O, ALA172O, ALA27P, ALA83P, ALA85P, ARG11P, ARG130P, ARG179O, ARG52P, ARG6P, ARG7O, ARG7P, ARG93P, ASN145O, ASN181O, ASN90P, ASP152O, ASP208P, ASP62P, ASP6O, ASP84P, ASP9P, GLN121O, GLN125O, GLN150O, GLN23O, GLN23P, GLN61P, GLU115O, GLU122O, GLU177O, GLU25P, GLU29P, GLU60P, GLU65P, GLU86P, GLY127O, GLY127P, GLY128O, GLY128P, GLY133P, GLY155O, GLY19O, GLY39O, GLY4P, GLY80P, HIS33P, ILE119O, ILE119P, ILE24O, ILE31P, ILE40O, ILE87P, LEU111O, LEU129P, LEU12O, LEU148O, LEU176O, LEU21O, LEU28P, LEU58P, LEU59P, LEU81P, LEU88P, LYS110O, LYS118O, LYS120P, LYS161O, LYS173O, LYS178O, LYS20O, LYS41O, LYS53P, MET120O, PHE10O, PHE132P, PHE147O, PHE158O, PHE15O, PHE175O, PRO131O, PRO131P, PRO153O, PRO153P, PRO159O, PRO17O, SER10P, SER114O, SER11O, SER126O, SER14O, SER154O, SER156O, SER16O, SER18O, SER30P, SER32P, SER56P, SER5P, SER63P, SER9O, THR109O, THR124O, THR12P, THR13O, THR13P, THR14O, THR163O, THR174O, THR55P, THR57P, THR5O, THR63P, THR64P, THR82P, THR91P, TRP160O, TRP180O, TYR123P, TYR149O, TYR157O, TYR207P, TYR22P, TYR26P, TYR68P, TYR8O, TYR8P, VAL129O, VAL134P, VAL151O, VAL24P, VAL54P
• O-Q: ARG10Q, ARG7O, ASP6O, ASP9Q, GLY127O, GLY7Q, LEU12Q, PHE10O, SER11O, SER9O, THR5O, TYR8O, TYR8Q
• O-R: ALA12R, ARG7O, GLU12R, GLY12R, SER12R
• O-S: ARG7O, GLN125S, GLY128S, GLY129S, MET4O, PHE10O, SER126S, THR5O, TYR127S, VAL13S
• O-T: ALA122T, ARG130T, ARG7O, ASN127T, ASP6O, HIS123T, LEU125T, MET4O, SER11T, SER128T, SER13T, THR5O, TYR126T, TYR8O, VAL129T, VAL14T
• O-U: ALA113U, ALA117U, ALA123O, ALA127U, ALA154U, ALA162U, ALA164U, ALA27O, ALA30O, ALA39U, ALA59O, ALA6U, ARG115U, ARG126U, ARG130O, ARG20U, ARG41U, ARG7O, ARG86O, ARG93O, ASN118U, ASN175U, ASN178U, ASP110U, ASP152U, ASP18U, ASP209O, ASP25O, ASP6O, ASP84O, ASP90O, ASP9U, GLN121U, GLN125U, GLN169U, GLN170U, GLN23O, GLN33O, GLU177U, GLU18U, GLU62O, GLY127O, GLY128O, GLY133O, GLY155U, GLY159U, GLY19U, GLY22O, GLY82O, HIS11U, HIS179U, ILE119O, ILE122U, ILE12U, ILE148U, ILE14U, ILE172U, ILE24O, LEU119U, LEU12O, LEU144U, LEU176U, LEU21U, LEU28O, LEU38U, LEU58O, LEU64O, LEU88O, LYS114U, LYS150U, LYS161U, LYS17U, LYS32O, LYS53O, LYS66O, LYS91O, MET116U, MET120O, MET129U, MET4O, MET60O, MET81O, PHE10O, PHE132O, PHE15U, PHE17U, PRO131O, PRO146U, PRO153O, PRO153U, PRO17U, PRO57O, PRO83O, SER120U, SER126O, SER147U, SER16U, SER54O, SER55O, SER56O, SER61O, SER65O, SER9O, THR124U, THR13O, THR13U, THR151U, THR163U, THR173U, THR174U, THR29O, THR5O, THR63O, TYR123U, TYR128U, TYR149U, TYR156U, TYR157U, TYR160U, TYR26O, TYR78O, TYR85O, TYR8O, TYR8U, VAL129O, VAL134O, VAL158U, VAL24U, VAL31O, VAL40U, VAL87O, VAL89O
• O-V: ALA184V, ALA96O, ARG102O, ARG189V, ARG36V, ARG86O, ARG93O, ASN62V, ASP183V, ASP21O, ASP90O, CYS176V, GLN57V, GLU185V, GLU64V, GLU73V, GLY104O, GLY21O, GLY60V, HIS35V, HIS66V, HIS97O, ILE21O, ILE37V, ILE41V, ILE59V, ILE63V, LEU187V, LEU21O, LEU34V, LEU58V, LEU65V, LEU68V, LEU69O, LEU70O, LYS101O, LYS182V, LYS40V, LYS91O, LYS94O, MET178V, MET82V, PRO21O, PRO39V, PRO72O, SER38V, SER61V, SER65O, SER67V, SER68O, SER71V, SER92O, THR21O, THR63O, THR70V, THR71O, THR98O, TRP42V, TYR106O, TYR186V, TYR21O, TYR69V, VAL175V, VAL177V, VAL87O, VAL89O, VAL95O
• O-W: ALA73W, ARG102O, ARG72W, ASN105W, ASN145O, ASP142O, GLN81W, GLU105O, GLU115O, GLU143O, GLU70W, GLU71W, GLU75W, GLU77W, GLU89W, GLY104O, GLY146O, HIS141O, HIS40W, ILE10O, ILE119W, ILE74W, LEU111O, LEU65W, LEU68W, LEU82W, LYS101O, LYS107W, LYS10W, LYS110O, LYS62W, LYS67W, LYS69W, PHE144O, PHE79W, PRO107O, PRO108O, PRO76W, SER10W, SER114O, SER84W, SER85W, SER86W, SER99O, THR21O, THR63W, THR78W, THR80W, TYR100O, TYR103O, TYR106O, TYR149O, TYR66W, VAL83W
• P-Q: ALA11Q, ALA162P, ALA172P, ALA27Q, ALA30Q, ALA83Q, ARG10Q, ARG114P, ARG115P, ARG11P, ARG130Q, ARG144P, ARG20P, ARG33Q, ARG53Q, ARG62Q, ARG6P, ARG7P, ARG86Q, ARG93Q, ASN152P, ASN156P, ASN82Q, ASP118P, ASP142P, ASP179P, ASP182P, ASP60Q, ASP84Q, ASP9P, ASP9Q, GLN120Q, GLN121P, GLN125P, GLN147P, GLN173P, GLN177P, GLN23Q, GLN59Q, GLU110P, GLU18P, GLU25P, GLU25Q, GLU29Q, GLU90Q, GLY122P, GLY127P, GLY127Q, GLY128P, GLY128Q, GLY133Q, GLY145P, GLY155P, GLY159P, GLY19P, GLY7Q, HIS126P, ILE119P, ILE14P, ILE14Q, ILE163P, ILE40P, ILE46P, ILE62Q, ILE87Q, LEU116P, LEU129P, LEU12Q, LEU148P, LEU175P, LEU176P, LEU192P, LEU21P, LEU28Q, LEU56Q, LEU58Q, LEU81Q, LEU88Q, LYS120P, LYS161P, LYS181P, LYS32Q, LYS57Q, LYS91Q, MET178P, MET41P, PHE132Q, PHE15P, PHE22Q, PHE78Q, PRO131Q, PRO153Q, PRO17P, PRO64Q, SER10P, SER117P, SER13Q, SER151P, SER154P, SER164P, SER16P, SER170P, SER5P, SER65Q, SER85Q, THR124P, THR12P, THR13P, THR150P, THR158P, THR169P, THR174P, THR55Q, THR61Q, THR63Q, TRP160P, TYR123P, TYR123Q, TYR146P, TYR149P, TYR14P, TYR157P, TYR180P, TYR22P, TYR26Q, TYR8P, TYR8Q, VAL109P, VAL113P, VAL119Q, VAL129Q, VAL134Q, VAL24P, VAL24Q, VAL31Q
• P-R: ARG10R, ARG11P, ARG6P, ARG7P, ASP9P, ASP9R, GLU12R, GLY11R, GLY12R, SER13R, SER5P, THR14R, TYR8P, VAL12R
• P-S: ARG6P, ARG7P, ASN7S, ASP11S, ASP9P, GLY10S, GLY128S, GLY4P, SER5P, THR14S, TYR127S, TYR8P, VAL13S
• P-T: ARG6P, ARG7P, ASN127T, ASN12T, ASP9T, GLN23T, GLY4P, GLY7T, LEU10T, SER11T, SER128T, SER13T, SER5P, TYR126T, TYR8P, TYR8T, VAL129T, VAL14T
• P-U: ALA127U, ALA6U, ARG10U, ARG6P, ARG7P, ASP9P, ASP9U, GLN23U, GLY4P, GLY7U, HIS11U, ILE12U, ILE14U, SER5P, TYR128U, TYR8P, TYR8U
• P-V: ASN220V, ASP21P, ASP223V, ASP72P, CYS222V, GLN221P, GLU219P, LYS69P, TYR220P, VAL21P
• P-W: ALA75P, ALA92P, ALA96P, ARG60W, ARG93P, ASN104P, ASN56W, ASN64W, ASN71P, ASN90P, ASN98P, ASP106P, ASP72P, GLN221P, GLN97P, GLU105P, GLU57W, GLU70W, GLU71W, HIS95P, ILE223P, ILE74P, ILE89P, ILE94P, LEU100P, LEU55W, LEU65W, LEU68W, LEU70P, LYS101P, LYS62W, LYS67W, LYS69P, LYS69W, LYS73P, MET58W, PHE59W, SER63P, THR102P, THR53W, THR54W, THR63P, THR63W, THR64P, THR91P, TYR103P, TYR61W, TYR66W, TYR68P, TYR99P
• P-X: ALA78X, ALA88X, ARG114P, ARG144P, ARG69X, ARG84X, ASN104P, ASN62X, ASN98P, ASP105X, ASP106P, ASP118P, ASP142P, ASP143P, ASP71X, GLN77X, GLN85X, GLN97P, GLU105P, GLU110P, GLU70X, GLU73X, GLU86X, ILE107P, ILE111P, ILE63X, ILE68X, LEU100P, LEU74X, LYS101P, LYS10X, LYS119X, LYS89X, PHE82X, PRO108P, PRO76X, SER67X, SER75X, SER80X, SER81X, THR102P, TYR103P, TYR14P, TYR66X, TYR72X, TYR99P, VAL79X, VAL83X
• Q-R: ALA117Q, ALA11Q, ALA162Q, ALA30R, ALA54R, ALA83R, ALA85R, ARG10Q, ARG10R, ARG114Q, ARG122Q, ARG126R, ARG130R, ARG173Q, ARG18Q, ARG86R, ARG93R, ASN179Q, ASN20R, ASP18Q, ASP62R, ASP84R, ASP9Q, ASP9R, GLN120Q, GLN121Q, GLN125Q, GLN150Q, GLN163Q, GLN23Q, GLN23R, GLU110Q, GLU12R, GLU145Q, GLU152Q, GLU174Q, GLU177Q, GLU25Q, GLU25R, GLU29R, GLU60R, GLU65R, GLU90R, GLY118Q, GLY11R, GLY127Q, GLY128Q, GLY12R, GLY133R, GLY155Q, GLY19Q, GLY39Q, GLY80R, HIS20Q, ILE14Q, ILE156Q, ILE21Q, ILE31R, ILE64R, LEU127R, LEU12Q, LEU148Q, LEU176Q, LEU192Q, LEU28R, LEU33R, LEU58R, LEU59R, LEU81R, LYS147Q, LYS178Q, LYS32R, LYS41Q, LYS66R, MET128R, MET88R, PHE123R, PHE132R, PHE15Q, PHE175Q, PHE22R, PRO131Q, PRO131R, PRO146Q, PRO153Q, PRO153R, PRO17Q, PRO57R, SER126Q, SER129R, SER13Q, SER154Q, SER158Q, SER159Q, SER161Q, SER16Q, SER27R, SER56R, SER61R, SER63R, SER87R, THR124Q, THR164Q, THR55R, THR82R, TRP160Q, TYR123Q, TYR149Q, TYR157Q, TYR180Q, TYR26R, TYR8Q, VAL129Q, VAL12R, VAL134R, VAL172Q, VAL24Q, VAL24R, VAL38Q, VAL40Q
• Q-S: ARG10Q, TYR127S
• Q-X: ALA56X, ALA61X, ALA92Q, ALA96Q, ARG100Q, ARG35X, ARG69X, ARG86Q, ARG93Q, ASN62X, ASP71Q, ASP71X, GLN54X, GLN60X, GLN64X, GLN97Q, GLU104Q, GLU57X, GLU70X, GLU90Q, GLU95Q, HIS73Q, ILE59X, ILE63X, ILE68X, ILE70Q, ILE89Q, LEU101Q, LEU65X, LYS69Q, LYS91Q, PHE55X, SER67X, SER68Q, SER72Q, SER98Q, THR102Q, TYR58X, TYR66X, VAL53X, VAL74Q, VAL94Q
• Q-Y: ALA77Y, ALA78Y, ALA79Y, ARG100Q, ARG114Q, ARG119Y, ARG14Q, ARG69Y, ASN85Y, ASP105Q, GLU104Q, GLU106Y, GLU110Q, GLU70Y, GLU72Y, HIS66Y, HIS99Q, ILE74Y, ILE82Y, LEU101Q, LEU103Q, LEU68Y, LYS10Y, LYS121Y, LYS71Y, LYS81Y, SER75Y, SER80Y, SER98Q, THR102Q, THR108Q, TYR111Q, TYR111Y, TYR157Q
• R-S: ALA120R, ALA12R, ALA162R, ALA164R, ALA172R, ALA174R, ALA27S, ALA30S, ALA41R, ALA55S, ALA82S, ALA85S, ARG10R, ARG122R, ARG126R, ARG130S, ARG159R, ARG20R, ARG53S, ARG5S, ARG86S, ARG93S, ASN123S, ASN161R, ASN178R, ASN54S, ASN6S, ASN90S, ASP118R, ASP11S, ASP56S, ASP84S, ASP9R, ASP9S, CYS117R, GLN114R, GLN125S, GLN173R, GLN23S, GLN33S, GLN64S, GLU110R, GLU12R, GLU152R, GLU170R, GLU175R, GLU179R, GLU18R, GLU25R, GLU25S, GLU29S, GLU57S, GLY10S, GLY11R, GLY128S, GLY129S, GLY12R, GLY133S, GLY155R, GLY19R, GLY39R, GLY80S, HIS150R, HIS18R, ILE31S, ILE38R, ILE40R, ILE68S, LEU119R, LEU121R, LEU148R, LEU176R, LEU177R, LEU192R, LEU21R, LEU28S, LEU58S, LEU81S, LYS119S, LYS122S, LYS163R, LYS32S, LYS52S, LYS65S, LYS66S, PHE123R, PHE149R, PHE157R, PHE15R, PHE22R, PHE22S, PRO131S, PRO153R, PRO153S, PRO17R, PRO83S, SER111R, SER115R, SER126S, SER12R, SER13R, SER154R, SER169R, SER16R, SER35S, SER59S, SER60S, THR124S, THR12S, THR14R, THR156R, TRP180R, TYR127S, TYR132S, TYR158R, TYR160R, TYR26S, TYR63S, VAL12R, VAL134S, VAL24R, VAL24S, VAL87S
• R-U: ASP9R, TYR8U
• R-Y: ALA92R, ALA95R, ALA96R, ARG64Y, ARG69Y, ARG72R, ARG86R, ARG93R, ASN100R, ASP104R, ASP62R, ASP71R, CYS63Y, GLN53Y, GLN62Y, GLU56Y, GLU65R, GLU67Y, GLU69R, GLU70Y, GLU90R, GLY60Y, GLY75R, HIS66Y, HIS73R, HIS91R, HIS99R, ILE223R, ILE64R, ILE67R, ILE70R, ILE74R, ILE89R, LEU101R, LEU59Y, LEU65Y, LEU68Y, LYS71Y, PHE221R, PHE54Y, SER61Y, SER63R, THR57Y, THR94R, THR98R, TRP55Y, TRP58Y, TYR102R, VAL68R, VAL97R
• R-Z: ALA143R, ALA79Z, ALA80Z, ALA95R, ALA96R, ARG81Z, ASN100R, ASN108R, ASN70Z, ASN77Z, ASN82Z, ASP104R, ASP106R, ASP142R, ASP144R, ASP14R, ASP69Z, ASP71Z, GLN114R, GLN147R, GLN84Z, GLU105R, GLU106Z, GLU110R, HIS70Z, HIS85Z, HIS99R, ILE107R, ILE76Z, ILE83Z, LEU101R, LEU112R, LEU74Z, LYS72Z, LYS73Z, PHE59Z, PHE68Z, SER111R, SER115R, SER62Z, SER75Z, SER78Z, THR98R, TRP65Z, TYR102R, TYR103R, TYR111Z, TYR119Z, TYR66Z, VAL109R, VAL63Z, VAL97R
• S-T: ALA120S, ALA146S, ALA164S, ALA172S, ALA27T, ALA30T, ARG111S, ARG130T, ARG178S, ARG20S, ARG41S, ARG86T, ARG93T, ASN123S, ASN127T, ASN12T, ASN156S, ASN33T, ASN64T, ASN6S, ASN7S, ASN90T, ASP118S, ASP11S, ASP18S, ASP84T, ASP9S, ASP9T, CYS117S, GLN121S, GLN125S, GLN152S, GLN23T, GLN62T, GLN68T, GLU110S, GLU150S, GLU159S, GLU177S, GLU25T, GLU32T, GLY10S, GLY113S, GLY128S, GLY129S, GLY133T, GLY155S, GLY162S, GLY19S, GLY39S, GLY7T, GLY80T, GLY85T, HIS114S, HIS123T, HIS147S, HIS87T, ILE18S, ILE54T, ILE82T, LEU10T, LEU115S, LEU116S, LEU148S, LEU149S, LEU160S, LEU176S, LEU180S, LEU21S, LEU40S, LEU58T, LEU59T, LEU81T, LEU88T, LYS119S, LYS122S, LYS173S, LYS29T, LYS57T, LYS63T, LYS66T, PHE132T, PHE151S, PHE15S, PHE18S, PHE22T, PHE4S, PRO131S, PRO131T, PRO153S, PRO153T, PRO17S, PRO61T, PRO83T, SER11T, SER126S, SER128T, SER144S, SER154S, SER16S, SER56T, THR124S, THR12S, THR14S, THR158S, THR163S, THR174S, THR179S, THR18S, THR55T, THR6T, TYR119T, TYR126T, TYR127S, TYR161S, TYR175S, TYR26T, TYR8S, TYR8T, VAL120T, VAL129T, VAL134T, VAL13S, VAL157S, VAL24S, VAL24T, VAL28T, VAL31T, VAL38S, VAL60T, VAL65T
• S-Z: ARG58Z, ARG86S, ARG93S, ASN104S, ASN61Z, ASN70Z, ASN90S, ASN97S, ASP69Z, ASP71S, ASP71Z, CYS70S, CYS96S, GLN94S, GLN95S, GLU72S, GLY75S, HIS67Z, HIS70Z, HIS73S, ILE223S, ILE68S, LEU101S, LEU107S, LEU92S, LYS106S, LYS57Z, LYS60Z, LYS64Z, LYS65S, LYS69S, MET74S, PHE103S, PHE221S, PHE68Z, SER100S, SER62Z, SER89S, THR222S, TRP65Z, TYR91S, TYR98S, VAL102S
• S-1: ALA108S, ALA701, ALA711, ALA721, ALA841, ARG105S, ARG111S, ASN101, ASN104S, ASN661, ASN701, ASP118S, ASP142S, ASP691, GLN1051, GLN891, GLU110S, GLU159S, GLU651, GLU711, GLU751, GLU811, GLY145S, HIS114S, HIS147S, ILE791, LEU101S, LEU107S, LEU591, LEU621, LEU691, LEU741, LEU831, LYS106S, LYS143S, PHE103S, PHE1091, PHE801, PRO691, PRO761, SER100S, SER101, SER144S, SER771, SER99S, THR851, TYR681, TYR781, TYR821, TYR98S, VAL102S, VAL109S, VAL861
• T-U: ALA113T, ALA122T, ALA127U, ALA146T, ALA163T, ALA164T, ALA172T, ALA174T, ALA27U, ALA30U, ALA85U, ALA88U, ALA89U, ARG10U, ARG115T, ARG130U, ARG169T, ARG20T, ARG86U, ARG91U, ASN127T, ASN12T, ASN21T, ASN32U, ASN87U, ASP114T, ASP18T, ASP56U, ASP60U, ASP84U, ASP9T, ASP9U, GLN118T, GLN121T, GLN170T, GLN23U, GLN33U, GLU152T, GLU175T, GLU177T, GLU211U, GLU25T, GLU25U, GLY117T, GLY133U, GLY155T, GLY159T, GLY162T, GLY19T, GLY39T, GLY5T, GLY7T, GLY7U, GLY80U, HIS11U, HIS123T, HIS147T, HIS18T, ILE12U, ILE38T, ILE40T, ILE67U, ILE82U, LEU10T, LEU125T, LEU132U, LEU148T, LEU151T, LEU176T, LEU179T, LEU58U, LEU59U, LEU90U, LYS161T, LYS173T, LYS178T, LYS29U, LYS41T, LYS52U, LYS57U, LYS93U, MET129U, MET150T, PHE138T, PHE15T, PHE28U, PHE68U, PRO110T, PRO131U, PRO153T, PRO153U, PRO17T, PRO55U, PRO61U, PRO81U, PRO83U, SER11T, SER128T, SER13T, SER154T, SER156T, SER16T, SER171T, SER65U, THR124T, THR13U, THR31U, THR34U, THR62U, THR63U, THR6T, TRP158T, TYR119T, TYR123U, TYR126T, TYR128U, TYR149T, TYR157T, TYR160T, TYR22U, TYR26U, TYR66U, TYR8T, TYR8U, VAL120T, VAL134U, VAL14T, VAL180T, VAL24T, VAL24U, VAL54U, VAL64U
• T-1: ALA671, ALA701, ALA721, ALA96T, ALA97T, ARG571, ARG72T, ARG86T, ARG93T, ASN64T, ASN661, ASN701, ASN90T, ASP611, ASP691, ASP711, ASP71T, GLN62T, GLN68T, GLU561, GLU651, GLU94T, GLY381, GLY92T, HIS221T, HIS541, HIS73T, ILE67T, ILE74T, LEU102T, LEU581, LEU591, LEU621, LEU691, LEU741, LYS100T, LYS101T, LYS104T, LYS222T, LYS225T, LYS601, LYS63T, LYS66T, PHE223T, PRO691, SER98T, THR641, TYR681, VAL631, VAL65T, VAL69T, VAL70T, VAL89T
• T-2: ALA111T, ALA792, ALA802, ARG115T, ASN1062, ASN144T, ASP1052, ASP114T, GLN118T, GLN692, GLU772, GLU852, GLU892, GLY722, HIS622, ILE107T, ILE582, LEU102T, LEU632, LEU652, LEU862, LYS100T, LYS101T, LYS102, LYS104T, LYS143T, LYS842, PHE112T, PHE832, PHE99T, PRO106T, PRO108T, PRO110T, PRO742, SER752, SER812, THR105T, THR732, THR782, TYR103T, TYR1112, TYR612, TYR662, TYR702, TYR882, VAL1192, VAL592, VAL822
• U-V: ALA113U, ALA117U, ALA79V, ARG100U, ARG115U, ARG72V, ARG75V, ASN118U, ASN62V, ASP105V, ASP106U, ASP110U, ASP142U, CYS109U, GLN81V, GLN85V, GLU143U, GLU14U, GLU73V, GLU98U, GLY104U, GLY145U, HIS66V, ILE63V, ILE74U, LEU112U, LEU119U, LEU144U, LEU65V, LEU68V, LEU80V, LEU83V, LYS102U, LYS114U, LYS84V, MET107U, MET116U, MET82V, PHE88V, PHE99U, PRO108U, PRO10V, PRO74V, SER140U, SER147U, SER67V, SER71V, SER78V, THR106V, THR70V, TYR101U, TYR103U, TYR105U, TYR149U, TYR157U, TYR69V, VAL111U, VAL76V, VAL77V
• U-2: ALA542, ALA562, ALA89U, ALA92U, ALA94U, ALA96U, ALA97U, ARG100U, ARG362, ARG72U, ARG91U, ASP106U, ASP392, ASP572, CYS69U, GLN532, GLN602, GLN692, GLU642, GLU95U, GLU98U, GLY104U, GLY722, HIS382, HIS622, ILE552, ILE582, ILE70U, LEU632, LEU652, LEU90U, LYS102U, LYS402, LYS93U, MET107U, PHE68U, PHE99U, PRO742, SER682, SER71U, THR672, THR732, TYR101U, TYR105U, TYR612, TYR662, TYR702, VAL592
• V-W: ALA122W, ALA158W, ALA173W, ALA212V, ALA27V, ALA32V, ALA49V, ALA50V, ALA54V, ALA73W, ALA97V, ARG187W, ARG189V, ARG197V, ARG208V, ARG91W, ASN145W, ASN161W, ASN220V, ASN30V, ASP114W, ASP120W, ASP123W, ASP132W, ASP150W, ASP182W, ASP223V, ASP28V, ASP51V, CYS118W, CYS138W, CYS222V, CYS31V, GLN133W, GLN157W, GLN193W, GLN22V, GLN57V, GLN81W, GLU121W, GLU139W, GLU143W, GLU147W, GLU149W, GLU153W, GLU183W, GLU216V, GLU32W, GLU53V, GLY117W, GLY128W, GLY136W, GLY172W, GLY209V, GLY39W, GLY93V, GLY96V, HIS36W, HIS40W, HIS86V, HIS94V, ILE116W, ILE119W, ILE125W, ILE155W, ILE177W, ILE178W, ILE218V, ILE221V, ILE25V, ILE34W, ILE95V, LEU115W, LEU141W, LEU146W, LEU151W, LEU159W, LEU160W, LEU189W, LEU18W, LEU214V, LEU58V, LEU87V, LEU87W, LYS12W, LYS179W, LYS181W, LYS186W, LYS190W, LYS200V, LYS202V, LYS205V, LYS215V, LYS29V, LYS30W, LYS67W, MET137W, MET191W, MET6W, PHE113W, PHE124W, PHE135W, PHE152W, PHE206V, PHE42W, PHE92W, PRO144W, PRO148W, PRO207V, PRO24V, SER-5W, SER10W, SER127W, SER131W, SER140W, SER156W, SER203V, SER20V, SER217V, SER84W, SER85W, THR154W, THR210V, THR211V, THR21V, THR48V, THR52V, TYR142W, TYR176W, TYR188W, TYR204V, TYR38W, TYR88W, TYR90V, VAL126W, VAL174W, VAL175W, VAL184W, VAL185W, VAL213V, VAL219V, VAL26V, VAL41W, VAL55V
• V-2: ALA115V, ALA133V, ALA134V, ALA136V, ALA242, ALA272, ALA492, ALA502, ALA542, ALA562, ARG1742, ARG292, ARG452, ASN282, ASN902, ASN942, ASP120V, ASP322, ASP512, ASP572, GLN532, GLN602, GLN81V, GLN85V, GLN91V, GLU139V, GLY117V, GLY122V, HIS114V, HIS116V, ILE113V, ILE262, ILE552, ILE582, LEU125V, LEU127V, LEU132V, LEU138V, LEU80V, LEU87V, LEU952, LYS84V, MET135V, PHE88V, SER112V, SER118V, SER126V, SER131V, SER482, THR119V, THR202, THR222, THR312, THR522, THR962, TRP142V, TYR123V, TYR124V, TYR252, TYR612, TYR98V, VAL121V, VAL302
• W-X: ALA126X, ALA49W, ALA88X, ARG60W, ARG7X, ARG84X, ARG90W, ARG90X, ASN-2W, ASN29W, ASN56W, ASP114X, ASP139X, ASP51W, GLN112X, GLN23W, GLN85X, GLU121X, GLU32W, GLU57W, GLY117X, GLY125X, GLY128X, GLY131X, GLY21W, GLY26W, GLY93W, HIS127X, ILE-3W, ILE113X, ILE90X, LEU115W, LEU116X, LEU122X, LEU18W, LEU20W, LEU25W, LEU48W, LEU55W, LEU87X, LYS119X, LYS30W, LYS89X, MET58W, PHE132X, PHE135X, PHE31W, PHE92W, PHE96W, PRO-6W, PRO123X, PRO94W, SER-8W, SER130X, SER136X, SER22W, SER24W, SER28W, SER81X, THR118X, THR50W, THR53W, THR54W, TRP171W, TYR115X, TYR124X, TYR129X, TYR133X, TYR61W, TYR95W, VAL120X, VAL27W, VAL52W, VAL97W
• X-Y: ALA49X, ALA93Y, ARG119Y, ARG22X, ARG35X, ARG92X, ARG93X, ASN85Y, ASP114Y, ASP116Y, ASP123Y, ASP29X, ASP31X, ASP32X, ASP51X, CYS126Y, GLN131Y, GLN54X, GLN60X, GLN89Y, GLN96X, GLU48X, GLU57X, GLY117Y, GLY122Y, GLY128Y, GLY23X, GLY50X, GLY92Y, ILE110Y, ILE124Y, ILE24X, LEU120Y, LEU27X, LEU86Y, LYS121Y, LYS28X, LYS33X, LYS81Y, LYS91Y, MET100Y, PHE125Y, PHE133Y, PHE55X, PRO94X, SER115Y, SER129Y, SER25X, SER30X, SER84Y, THR118Y, THR132Y, THR21X, THR52X, TYR111Y, TYR112Y, TYR135Y, TYR58X, TYR88Y, TYR90Y, TYR95X, VAL113Y, VAL127Y, VAL20X, VAL26X, VAL53X, VAL87Y, VAL97X
• Y-Z: ALA126Z, ALA130Z, ALA131Z, ALA20Y, ALA22Y, ALA27Y, ALA49Y, ALA50Y, ALA93Y, ARG121Z, ARG125Z, ARG81Z, ARG91Z, ASN143Z, ASN82Z, ASP114Z, ASP139Z, ASP191Y, ASP51Y, CYS124Z, CYS52Y, GLN123Z, GLN29Y, GLN53Y, GLN84Z, GLU120Z, GLU122Z, GLU194Y, GLU201Y, GLU56Y, GLY117Z, GLY127Z, GLY171Y, GLY193Y, GLY211Y, GLY48Y, GLY89Z, GLY92Y, GLY94Y, HIS85Z, HIS98Z, ILE134Z, ILE35Y, LEU133Z, LEU86Y, LEU86Z, LEU87Z, LEU95Y, LYS14Z, LYS32Y, LYS33Y, MET135Z, MET45Y, MET97Y, PHE113Z, PHE137Z, PHE54Y, PHE92Z, PRO115Z, PRO136Z, SER112Z, SER115Y, SER118Z, SER132Z, SER18Y, SER28Y, SER61Y, SER96Y, THR30Y, THR57Y, TRP197Y, TRP25Y, TRP55Y, TRP58Y, TYR119Z, TYR14Z, TYR88Z, TYR90Y, VAL116Z, VAL26Y, VAL31Y, VAL34Y
• Z-1: ALA1261, ALA1311, ALA49Z, ALA50Z, ALA54Z, ALA841, ARG1111, ARG1391, ARG141, ARG193Z, ARG19Z, ARG29Z, ARG58Z, ARG901, ARG911, ASN-2Z, ASN-7Z, ASN1141, ASN1351, ASN20Z, ASN27Z, ASN931, ASP-3Z, ASP141, ASP171Z, ASP23Z, ASP51Z, ASP53Z, GLN-61, GLN-71, GLN-9Z, GLN891, GLU141, GLU190Z, GLU31Z, GLU811, GLY-4Z, GLY1171, GLY1281, GLY52Z, HIS1321, ILE21Z, ILE26Z, LEU1151, LEU1161, LEU1251, LEU191Z, LEU55Z, LEU951, LYS57Z, LYS90Z, LYS921, MET871, MET921, PHE-8Z, PHE188Z, PHE35Z, PHE48Z, PHE801, PHE93Z, PRO-51, PRO-6Z, PRO1231, PRO1361, PRO32Z, PRO941, PRO94Z, SER1211, SER1221, SER25Z, SER28Z, SER921, THR-81, THR1191, THR1241, THR22Z, THR851, TRP961, TYR-5Z, TYR1121, TYR1201, TYR24Z, TYR30Z, TYR821, TYR881, TYR95Z, TYR96Z, VAL1131, VAL1181, VAL141, VAL97Z
• 1-2: ALA1252, ALA1272, ARG271, ARG571, ARG901, ASN291, ASN931, ASP481, ASP511, ASP922, CYS872, GLN-61, GLN-71, GLN531, GLU561, GLU852, GLU892, GLY1162, GLY1172, GLY1282, GLY201, GLY301, GLY982, HIS1202, HIS541, ILE-41, ILE1002, ILE1132, ILE1262, ILE32, ILE491, ILE551, ILE992, LEU1152, LEU1222, LEU251, LEU261, LEU581, LEU951, LYS1212, LYS842, LYS912, MET521, MET921, PHE281, PRO-51, PRO1142, PRO941, SER1182, SER1312, SER462, SER501, SER812, THR-21, THR-81, THR1122, THR1322, TRP961, TYR1242, TYR1352, TYR221, TYR882, VAL-31, VAL1192, VAL311