2GL7

crystal structure of a beta-catenin/bcl9/tcf4 complex

• Total interactions analyzed: 15
• Total true interactions: 6
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 159
  • Norm. En. per Res.: -3.8984
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-106.296	-101.3421	-412.212	-619.8501	159	17	8	17202	5	53	36
A-C	-9.1842	-55.5667	-125.684	-190.4349	57	2	9	5992	4	18	19
A-D	0.0	-2.9874	-84.9239	-87.9112	63	1	1	4331	0	23	14
C-D	0.0	0.0	-1.0293	-1.0293	7	0	0	146	0	1	1
D-E	-87.131	-69.2066	-396.619	-552.9566	156	21	9	16277	8	46	28
D-F	-7.7503	-52.2448	-79.9453	-139.9404	43	0	4	4006	3	17	16

Interface residues

• A-B: ALA14B, ALA255A, ALA295A, ALA305A, ALA391A, ALA392A, ALA421A, ALA42B, ALA464A, ALA467A, ALA478A, ALA509A, ALA518A, ALA576A, ARG342A, ARG376A, ARG386A, ARG39B, ARG469A, ARG474A, ARG515A, ARG582A, ARG612A, ASN15B, ASN220A, ASN261A, ASN290A, ASN308A, ASN380A, ASN387A, ASN426A, ASN430A, ASN431A, ASN50B, ASN516A, ASN609A, ASP16B, ASP23B, ASP249A, ASP299A, ASP390A, ASP40B, ASP43B, ASP459A, CYS300A, CYS350A, CYS419A, CYS429A, CYS466A, GLN27B, GLN302A, GLN309A, GLN482A, GLU17B, GLU24B, GLU26B, GLU28B, GLU334A, GLU38B, GLU458A, GLU462A, GLU568A, GLU571A, GLY13B, GLY216A, GLY25B, GLY307A, GLY422A, GLY512A, GLY572A, GLY575A, HIS219A, HIS223A, HIS260A, HIS265A, HIS470A, HIS475A, HIS578A, ILE19B, ILE256A, ILE296A, ILE303A, ILE423A, ILE465A, ILE514A, ILE579A, LEU12B, LEU18B, LEU252A, LEU259A, LEU262A, LEU263A, LEU264A, LEU294A, LEU336A, LEU347A, LEU385A, LEU388A, LEU41B, LEU424A, LEU427A, LEU471A, LEU48B, LEU513A, LEU517A, LEU519A, LYS180A, LYS22B, LYS270A, LYS292A, LYS312A, LYS335A, LYS345A, LYS354A, LYS435A, LYS45B, LYS508A, PHE21B, PHE253A, PHE293A, PRO463A, PRO505A, SER20B, SER222A, SER250A, SER348A, SER351A, SER389A, SER425A, SER46B, SER473A, SER47B, THR257A, THR258A, THR297A, THR298A, THR339A, THR384A, THR393A, THR418A, THR428A, THR461A, THR472A, TRP338A, TRP383A, TYR254A, TYR306A, TYR333A, TYR432A, TYR654A, VAL251A, VAL291A, VAL343A, VAL346A, VAL349A, VAL44B, VAL49B, VAL511A, VAL564A
• A-C: ALA149A, ALA152A, ALA171A, ALA172A, ARG151A, ARG359C, ARG361C, ARG367C, ARG371C, ASN169A, ASP144A, ASP145A, ASP162A, ASP164A, ASP368C, GLN165A, GLN177A, GLN355C, GLN364C, GLN370C, GLU147A, GLU155A, GLU163A, GLU360C, HIS176A, HIS358C, ILE153A, ILE188A, ILE369C, LEU148A, LEU156A, LEU159A, LEU160A, LEU178A, LEU356C, LEU363C, LEU366C, LEU373C, LYS158A, LYS170A, LYS180A, LYS181A, MET174A, MET372C, PHE374C, PRO154A, SER179A, SER184A, SER362C, THR150A, THR157A, THR365C, VAL166A, VAL167A, VAL168A, VAL173A, VAL175A
• A-D: ALA146A, ALA149A, ALA152A, ALA183A, ALA187A, ALA230D, ALA239D, ALA269D, ALA272D, ALA276D, ALA638D, ARG151A, ARG190A, ARG225A, ARG274D, ARG549A, ASN308D, ASP144A, ASP145A, GLN143A, GLN193A, GLN203D, GLN266D, GLN309D, GLU142A, GLU147A, GLU155A, GLU226A, GLU267D, GLU310D, GLU642D, GLY235D, GLY236D, GLY268D, GLY307D, GLY635D, HIS186A, ILE153A, ILE231D, ILE237D, LEU148A, LEU156A, LEU229A, LEU229D, LEU275D, LEU313D, LYS158A, LYS233A, LYS233D, LYS270D, MET194A, MET271D, PHE232D, PRO154A, PRO192A, PRO238D, SER191A, SER234D, THR150A, THR157A, VAL199D, VAL273D, VAL561A
• C-D: ASP368C, ILE369C, LEU373C, LYS233D, MET372C, PRO192D, THR365C
• D-E: ALA14E, ALA255D, ALA295D, ALA305D, ALA391D, ALA392D, ALA421D, ALA42E, ALA464D, ALA467D, ALA509D, ALA518D, ALA576D, ARG212D, ARG274D, ARG342D, ARG376D, ARG386D, ARG469D, ARG474D, ARG515D, ARG565D, ARG582D, ASN15E, ASN220D, ASN261D, ASN290D, ASN308D, ASN380D, ASN387D, ASN426D, ASN430D, ASN431D, ASN50E, ASN516D, ASN609D, ASP16E, ASP23E, ASP249D, ASP299D, ASP390D, ASP40E, ASP43E, ASP459D, CYS300D, CYS350D, CYS419D, CYS429D, CYS466D, GLN27E, GLN302D, GLN309D, GLN482D, GLU17E, GLU24E, GLU26E, GLU28E, GLU462D, GLU568D, GLU571D, GLY13E, GLY216D, GLY25E, GLY307D, GLY422D, GLY512D, GLY572D, GLY575D, HIS219D, HIS223D, HIS260D, HIS265D, HIS470D, HIS475D, HIS578D, ILE19E, ILE256D, ILE296D, ILE303D, ILE423D, ILE465D, ILE514D, ILE579D, LEU12E, LEU18E, LEU252D, LEU259D, LEU262D, LEU263D, LEU264D, LEU294D, LEU301D, LEU304D, LEU336D, LEU344D, LEU347D, LEU385D, LEU388D, LEU41E, LEU424D, LEU427D, LEU471D, LEU48E, LEU513D, LEU517D, LEU519D, LYS22E, LYS270D, LYS292D, LYS312D, LYS335D, LYS345D, LYS354D, LYS435D, LYS45E, LYS508D, PHE21E, PHE253D, PHE293D, PRO463D, PRO505D, SER20E, SER222D, SER250D, SER348D, SER389D, SER425D, SER46E, SER473D, SER47E, THR257D, THR258D, THR297D, THR298D, THR339D, THR384D, THR393D, THR418D, THR428D, THR472D, TRP338D, TRP383D, TYR254D, TYR306D, TYR333D, TYR432D, TYR654D, VAL291D, VAL343D, VAL346D, VAL349D, VAL44E, VAL49E, VAL511D, VAL564D, VAL613D
• D-F: ALA149D, ALA152D, ALA171D, ALA172D, ARG151D, ARG359F, ARG361F, ARG367F, ARG371F, ASN161D, ASN169D, ASP162D, ASP164D, ASP368F, GLN165D, GLN355F, GLN364F, GLN370F, GLU155D, GLU163D, GLU360F, HIS358F, ILE153D, ILE369F, LEU148D, LEU156D, LEU159D, LEU160D, LEU178D, LEU356F, LEU363F, LEU366F, LYS158D, LYS170D, MET174D, SER362F, THR157D, THR365F, VAL166D, VAL167D, VAL168D, VAL173D, VAL175D