2GHP

crystal structure of the n-terminal 3 rna binding domains of the yeast splicing factor prp24

• Total interactions analyzed: 28
• Total true interactions: 17
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 89
  • Norm. En. per Res.: -3.5286
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-70.6711	-16.8869	-226.488	-314.046	89	9	5	8560	0	18	28
A-C	-65.659	114.3507	-298.526	-249.8343	105	10	0	10346	10	64	66
A-D	-14.198	-44.3094	-59.3737	-117.8811	60	10	0	3215	4	8	12
A-F	0.0	0.0	-2.1485	-2.1485	12	0	0	225	0	2	2
B-C	-5.553	-44.7279	-71.3039	-121.5847	56	12	0	3215	4	8	12
B-D	-104.5324	132.6771	-296.599	-268.4543	104	11	0	10243	10	60	69
C-D	-74.8158	-19.8152	-207.78	-302.411	88	6	5	8253	0	18	28
C-F	0.0	0.0	-0.0241	-0.0241	3	0	0	11	0	0	0
C-G	0.0	0.0	-5.4262	-5.4262	11	0	0	363	0	1	3
D-F	0.0	0.0	-0.0457	-0.0457	5	0	0	19	0	2	3
D-H	0.0	0.0	-0.0596	-0.0596	3	0	0	23	0	2	1
E-F	-71.0673	-15.8624	-211.343	-298.2727	87	8	5	8309	0	18	28
E-G	-95.1525	100.8382	-294.536	-288.8502	104	16	0	10500	10	62	69
E-H	-21.696	-51.1766	-76.5249	-149.3975	58	9	0	3308	4	8	12
F-G	-47.1788	-41.1862	-69.4099	-157.7748	54	7	0	3128	4	8	12
F-H	-125.9965	136.3919	-287.768	-277.3726	106	13	1	10210	9	60	69
G-H	-70.536	-20.861	-209.074	-300.4709	88	9	5	8286	0	18	28

Interface residues

• A-B: ALA269A, ALA269B, ARG158A, ARG158B, ARG268A, ARG274A, ARG274B, ARG280A, ARG280B, ASN123A, ASN123B, ASN132A, ASN132B, ASN141A, ASN141B, ASN179A, ASN179B, ASN216A, ASN216B, ASN252A, ASN252B, ASN273A, ASN273B, ASN279A, ASN279B, ASP135A, ASP135B, ASP139A, ASP139B, GLN138A, GLN138B, GLN271A, GLN271B, GLU176A, GLU176B, GLU184A, GLU184B, GLU281A, GLU281B, GLY180A, GLY180B, GLY185A, GLY185B, GLY278A, GLY278B, ILE140A, ILE140B, ILE183A, ILE183B, ILE282A, ILE282B, LEU136A, LEU136B, LEU178A, LEU178B, LEU181A, LEU181B, LEU188A, LEU188B, LEU270A, LEU270B, LEU276A, LEU276B, LEU277A, LEU277B, LYS177A, LYS177B, LYS182A, LYS182B, PHE124A, PHE124B, PRO125A, PRO125B, PRO126A, PRO126B, SER275A, SER275B, THR187A, THR187B, TYR128A, TYR128B, TYR186A, TYR186B, VAL175A, VAL175B, VAL189A, VAL189B, VAL284A, VAL284B
• A-C: ALA171A, ALA171C, ALA287A, ALA287C, ARG172A, ARG172C, ARG210A, ARG210C, ARG215A, ARG215C, ASN141A, ASN141C, ASN179C, ASN194A, ASN194C, ASN79A, ASP139A, ASP139C, ASP170A, ASP170C, ASP264A, ASP264C, ASP288A, ASP288C, CYS174A, CYS174C, GLN138C, GLU116A, GLU116C, GLU169A, GLU169C, GLU176A, GLU176C, GLU208A, GLU208C, GLU211A, GLU211C, GLU267A, GLU267C, GLY209A, GLY209C, ILE140A, ILE140C, ILE212A, ILE212C, LEU119A, LEU119C, LEU137A, LEU137C, LEU196A, LEU196C, LEU207A, LEU207C, LEU270A, LEU270C, LEU286A, LEU286C, LEU76A, LEU76C, LYS168A, LYS168C, LYS177A, LYS177C, LYS191A, LYS191C, LYS263A, LYS263C, LYS289A, LYS289C, LYS290A, LYS290C, LYS77A, LYS77C, PRO195A, PRO195C, PRO291A, PRO291C, SER167A, SER167C, SER193A, SER193C, SER285A, SER285C, THR115A, THR115C, THR118A, THR118C, THR166A, THR166C, THR206A, THR206C, TRP120A, TRP120C, TYR173A, TYR173C, VAL142A, VAL142C, VAL143A, VAL143C, VAL165A, VAL165C, VAL175A, VAL175C, VAL192A, VAL192C
• A-D: ALA244A, ALA244D, ALA256A, ALA256D, ALA287A, ALA287D, ARG215A, ARG215D, ARG274A, ARG274D, ARG280A, ARG280D, ASN216A, ASN216D, ASN241A, ASN241D, ASN252A, ASN252D, ASN253A, ASN253D, ASN273A, ASN273D, ASP288A, ASP288D, CYS254A, CYS254D, CYS255A, CYS255D, GLN246A, GLN246D, GLU211D, GLU281A, GLU281D, GLY245A, ILE214A, ILE214D, ILE242A, ILE242D, ILE282A, ILE282D, LEU217A, LEU217D, LEU222D, LEU286A, LEU286D, LYS290A, LYS290D, PHE251A, PHE251D, PHE257A, PHE257D, PRO243A, PRO243D, PRO291A, PRO291D, SER283A, SER283D, SER285A, SER285D, VAL284A
• A-F: ALA244A, ALA244F, GLU224F, GLU238F, GLY245A, GLY245F, ILE240F, LEU207A, LYS239F, LYS290A, PRO243A, PRO291A
• B-C: ALA244B, ALA244C, ALA256B, ALA256C, ALA287B, ALA287C, ARG215B, ARG215C, ARG274B, ARG274C, ARG280B, ARG280C, ASN216B, ASN216C, ASN241B, ASN241C, ASN252B, ASN252C, ASN253B, ASN253C, ASN273B, ASN273C, ASP288B, ASP288C, CYS254B, CYS254C, CYS255B, CYS255C, GLN246B, GLN246C, GLU211B, GLU211C, GLU281B, GLU281C, ILE214B, ILE214C, ILE242C, ILE282B, ILE282C, LEU217B, LEU217C, LEU286B, LEU286C, LYS290B, LYS290C, PHE251B, PHE251C, PHE257B, PHE257C, PRO243B, PRO243C, PRO291B, SER283B, SER283C, SER285B, SER285C
• B-D: ALA171B, ALA171D, ALA287B, ALA287D, ARG172B, ARG172D, ARG210B, ARG210D, ARG215B, ARG215D, ASN141B, ASN141D, ASN194B, ASN194D, ASP139B, ASP139D, ASP170B, ASP170D, ASP264B, ASP264D, ASP288B, ASP288D, CYS174B, CYS174D, GLN138B, GLN138D, GLU116B, GLU116D, GLU169B, GLU169D, GLU176B, GLU176D, GLU208B, GLU208D, GLU211B, GLU211D, GLU267B, GLU267D, GLY209B, GLY209D, ILE140B, ILE140D, ILE212B, ILE212D, LEU119B, LEU119D, LEU137B, LEU137D, LEU196B, LEU196D, LEU207B, LEU207D, LEU270B, LEU270D, LEU286B, LEU286D, LEU76B, LEU76D, LYS168B, LYS168D, LYS177B, LYS177D, LYS191B, LYS191D, LYS263B, LYS263D, LYS289B, LYS289D, LYS290B, LYS290D, LYS77B, LYS77D, PRO195B, PRO195D, PRO291B, PRO291D, SER167B, SER167D, SER193B, SER193D, SER285B, SER285D, THR115B, THR115D, THR118B, THR118D, THR166B, THR166D, THR206B, THR206D, TRP120B, TRP120D, TYR173B, TYR173D, VAL142B, VAL142D, VAL143B, VAL143D, VAL165B, VAL165D, VAL175B, VAL175D, VAL192B, VAL192D
• C-D: ALA269C, ALA269D, ARG158C, ARG158D, ARG268D, ARG274C, ARG274D, ARG280C, ARG280D, ASN123C, ASN123D, ASN132C, ASN132D, ASN141C, ASN141D, ASN179C, ASN179D, ASN216C, ASN216D, ASN252C, ASN273C, ASN273D, ASN279C, ASN279D, ASP135C, ASP135D, ASP139C, ASP139D, GLN138C, GLN138D, GLN271C, GLN271D, GLU176C, GLU176D, GLU184C, GLU184D, GLU281C, GLU281D, GLY180C, GLY180D, GLY185C, GLY185D, GLY278C, GLY278D, ILE140C, ILE140D, ILE183C, ILE183D, ILE282C, ILE282D, LEU136C, LEU136D, LEU178C, LEU178D, LEU181C, LEU181D, LEU188C, LEU188D, LEU270C, LEU270D, LEU276C, LEU276D, LEU277C, LEU277D, LYS177C, LYS177D, LYS182C, LYS182D, PHE124C, PHE124D, PRO125C, PRO125D, PRO126C, PRO126D, SER275C, SER275D, THR187C, THR187D, TYR128C, TYR128D, TYR186C, TYR186D, VAL175C, VAL175D, VAL189C, VAL189D, VAL284C, VAL284D
• C-F: ALA244F, GLY245F, LYS77C
• C-G: ALA244G, ASN107C, ASN79C, GLN106C, GLN246G, GLY245G, LYS247G, LYS50C, LYS77C, LYS78C, PHE80C
• D-F: ASN241F, LYS239F, LYS247D, LYS290F, PHE251D
• D-H: LYS247D, LYS77H, THR219D
• E-F: ALA269E, ALA269F, ARG158E, ARG158F, ARG274E, ARG274F, ARG280E, ARG280F, ASN123E, ASN123F, ASN132E, ASN132F, ASN141E, ASN141F, ASN179E, ASN179F, ASN216E, ASN216F, ASN252E, ASN273E, ASN273F, ASN279E, ASN279F, ASP135E, ASP135F, ASP139E, ASP139F, GLN138E, GLN138F, GLN271E, GLN271F, GLU176E, GLU176F, GLU184E, GLU184F, GLU281E, GLU281F, GLY180E, GLY180F, GLY185E, GLY185F, GLY278E, GLY278F, ILE140E, ILE140F, ILE183E, ILE183F, ILE282E, ILE282F, LEU136E, LEU136F, LEU178E, LEU178F, LEU181E, LEU181F, LEU188E, LEU188F, LEU270E, LEU270F, LEU276E, LEU276F, LEU277E, LEU277F, LYS177E, LYS177F, LYS182E, LYS182F, PHE124E, PHE124F, PRO125E, PRO125F, PRO126E, PRO126F, SER275E, SER275F, THR187E, THR187F, TYR128E, TYR128F, TYR186E, TYR186F, VAL175E, VAL175F, VAL189E, VAL189F, VAL284E, VAL284F
• E-G: ALA171E, ALA171G, ALA287E, ALA287G, ARG172E, ARG172G, ARG210E, ARG210G, ARG215E, ARG215G, ASN141E, ASN141G, ASN194E, ASN194G, ASN79E, ASP139E, ASP139G, ASP170E, ASP170G, ASP264E, ASP264G, ASP288E, ASP288G, CYS174E, CYS174G, GLN138G, GLU116E, GLU116G, GLU169E, GLU169G, GLU176E, GLU176G, GLU208E, GLU208G, GLU211E, GLU211G, GLU267E, GLU267G, GLY209E, GLY209G, ILE140E, ILE140G, ILE212E, ILE212G, LEU119E, LEU119G, LEU137E, LEU137G, LEU196E, LEU196G, LEU207E, LEU207G, LEU270E, LEU270G, LEU286E, LEU286G, LEU76E, LEU76G, LYS168E, LYS168G, LYS177E, LYS177G, LYS191E, LYS191G, LYS263E, LYS263G, LYS289E, LYS289G, LYS290E, LYS290G, LYS77E, LYS77G, PRO195E, PRO195G, PRO291E, PRO291G, SER167E, SER167G, SER193E, SER193G, SER285E, SER285G, THR115E, THR115G, THR118E, THR118G, THR166E, THR166G, THR206E, THR206G, TRP120E, TRP120G, TYR173E, TYR173G, VAL142E, VAL142G, VAL143E, VAL143G, VAL165E, VAL165G, VAL175E, VAL175G, VAL192E, VAL192G
• E-H: ALA244E, ALA244H, ALA256E, ALA256H, ALA287E, ALA287H, ARG215E, ARG215H, ARG274E, ARG274H, ARG280E, ARG280H, ASN216E, ASN216H, ASN241E, ASN241H, ASN252E, ASN252H, ASN253E, ASN253H, ASN273E, ASN273H, ASP288E, ASP288H, CYS254E, CYS254H, CYS255E, CYS255H, GLN246E, GLN246H, GLU281E, GLU281H, GLY245E, ILE214E, ILE214H, ILE242E, ILE242H, ILE282E, ILE282H, LEU217E, LEU217H, LEU222H, LEU286E, LEU286H, LYS290E, LYS290H, PHE251E, PHE251H, PHE257E, PHE257H, PRO243E, PRO243H, PRO291H, SER283E, SER283H, SER285E, SER285H, VAL284H
• F-G: ALA244G, ALA256F, ALA256G, ALA287F, ALA287G, ARG215F, ARG215G, ARG274F, ARG274G, ARG280F, ARG280G, ASN216F, ASN216G, ASN241G, ASN252F, ASN252G, ASN253F, ASN253G, ASN273F, ASN273G, ASP288F, ASP288G, CYS254F, CYS254G, CYS255F, CYS255G, GLN246F, GLN246G, GLU211F, GLU281F, GLU281G, ILE214F, ILE214G, ILE242G, ILE282F, ILE282G, LEU217F, LEU217G, LEU222G, LYS289F, LYS290F, LYS290G, PHE251F, PHE251G, PHE257F, PHE257G, PRO243F, PRO243G, PRO291F, SER283F, SER283G, SER285F, SER285G, VAL284F
• F-H: ALA171F, ALA171H, ALA287F, ALA287H, ARG172F, ARG172H, ARG210F, ARG210H, ARG215F, ARG215H, ASN141F, ASN141H, ASN194F, ASN194H, ASP139F, ASP139H, ASP170F, ASP170H, ASP264F, ASP264H, ASP288F, ASP288H, CYS174F, CYS174H, GLN138F, GLN138H, GLU116F, GLU116H, GLU169F, GLU169H, GLU176F, GLU176H, GLU208F, GLU208H, GLU211F, GLU211H, GLU267F, GLU267H, GLY209F, GLY209H, ILE140F, ILE140H, ILE212F, ILE212H, LEU119F, LEU119H, LEU137F, LEU137H, LEU196F, LEU196H, LEU207F, LEU207H, LEU270F, LEU270H, LEU286F, LEU286H, LEU76F, LEU76H, LYS168F, LYS168H, LYS177F, LYS177H, LYS191F, LYS191H, LYS263F, LYS263H, LYS289F, LYS289H, LYS290F, LYS290H, LYS77F, LYS77H, LYS78H, PRO195F, PRO195H, PRO291F, PRO291H, SER167F, SER167H, SER193F, SER193H, SER285F, SER285H, SER75H, THR115F, THR115H, THR118F, THR118H, THR166F, THR166H, THR206F, THR206H, TRP120F, TRP120H, TYR173F, TYR173H, VAL142F, VAL142H, VAL143F, VAL143H, VAL165F, VAL165H, VAL175F, VAL175H, VAL192F, VAL192H
• G-H: ALA269G, ALA269H, ARG158G, ARG158H, ARG268G, ARG274G, ARG274H, ARG280G, ARG280H, ASN123G, ASN123H, ASN132G, ASN132H, ASN141G, ASN141H, ASN179G, ASN179H, ASN216G, ASN216H, ASN252G, ASN273G, ASN273H, ASN279G, ASN279H, ASP135G, ASP135H, ASP139G, ASP139H, GLN138G, GLN138H, GLN271G, GLN271H, GLU176G, GLU176H, GLU184G, GLU184H, GLU281G, GLU281H, GLY180G, GLY180H, GLY185G, GLY185H, GLY278G, GLY278H, ILE140G, ILE140H, ILE183G, ILE183H, ILE282G, ILE282H, LEU136G, LEU136H, LEU178G, LEU178H, LEU181G, LEU181H, LEU188G, LEU188H, LEU270G, LEU270H, LEU276G, LEU276H, LEU277G, LEU277H, LYS177G, LYS177H, LYS182G, LYS182H, PHE124G, PHE124H, PRO125G, PRO125H, PRO126G, PRO126H, SER275G, SER275H, THR187G, THR187H, TYR128G, TYR128H, TYR186G, TYR186H, VAL175G, VAL175H, VAL189G, VAL189H, VAL284G, VAL284H