2GGE

crystal structure of mandelate racemase/muconate lactonizing enzyme from bacillus subtilis complexed with mg++ at 1.8 a

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: E-H
  • Int. Res.: 99
  • Norm. En. per Res.: -3.0859
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.7076	10.9584	-271.389	-290.1383	142	9	10	10875	0	26	36
A-D	-59.4901	-25.93	-217.583	-303.0031	99	12	0	7942	2	39	27
A-G	-4.5563	-28.975	-150.118	-183.6493	91	4	4	6721	1	24	20
A-H	-43.4561	-36.8253	-207.957	-288.2384	100	12	0	7821	3	37	26
B-C	-62.7028	-27.1479	-205.341	-295.1917	99	10	0	7700	2	36	27
B-D	-7.1269	-4.1222	-176.387	-187.6361	97	4	5	7541	0	24	21
B-G	-52.7196	-30.631	-200.896	-284.2466	98	6	0	7752	2	37	27
C-D	-42.1493	4.4016	-281.372	-319.1197	141	11	9	11027	0	26	36
C-E	0.0	-39.6494	-143.539	-183.1884	88	0	4	6477	1	26	19
C-F	-49.5642	-29.0657	-199.101	-277.7309	96	7	0	7682	2	37	27
D-E	-49.3182	-25.3597	-200.373	-275.0509	95	9	0	7648	2	36	27
E-F	-35.0428	-2.837	-280.653	-318.5328	140	8	10	10862	0	26	36
E-H	-59.9374	-38.1199	-207.444	-305.5013	99	8	0	7973	2	37	28
F-G	-52.0579	-31.6848	-203.661	-287.4038	98	11	0	7656	2	37	25
F-H	0.0	-4.6248	-123.32	-127.9448	90	1	4	5777	0	20	18
G-H	-39.1104	10.9514	-254.7	-282.8589	144	11	10	10881	0	26	36

Interface residues

• A-B: ALA104A, ALA104B, ALA105A, ALA105B, ALA107A, ALA107B, ALA108A, ALA108B, ALA249A, ALA249B, ALA283A, ALA2B, ALA307A, ALA307B, ALA309A, ALA309B, ALA75A, ALA75B, ARG119A, ARG119B, ARG121A, ARG121B, ARG258A, ARG258B, ARG277A, ARG277B, ARG284A, ARG284B, ARG78A, ARG78B, ARG83A, ARG83B, ASN271A, ASN271B, ASP109A, ASP109B, ASP274A, ASP274B, ASP278A, ASP278B, CYS110A, CYS110B, CYS113A, CYS113B, CYS279A, CYS279B, CYS310A, CYS310B, GLN250A, GLN250B, GLN257A, GLN257B, GLN281A, GLN281B, GLN74A, GLN74B, GLN86A, GLN86B, GLU114A, GLU114B, GLU275A, GLU275B, GLY117A, GLY117B, GLY118A, GLY118B, GLY247A, GLY247B, GLY287A, GLY287B, GLY76A, GLY76B, HIS321A, HIS321B, LEU100A, LEU100B, LEU115A, LEU115B, LEU255A, LEU255B, LEU282A, LEU282B, LEU311A, LEU311B, LEU3A, LEU3B, LEU79A, LEU79B, LEU81A, LEU81B, LYS316A, LYS316B, LYS318B, LYS351A, LYS353A, LYS353B, LYS87A, LYS87B, PHE276A, PHE276B, PHE286A, PHE286B, PRO248A, PRO248B, PRO253A, PRO253B, PRO312A, PRO312B, PRO313A, PRO313B, SER111A, SER256A, SER256B, SER315A, SER315B, SER77A, SER77B, SER80A, SER80B, THR101A, THR101B, THR84A, THR84B, TRP116A, TRP116B, TRP314A, TRP314B, TYR120A, TYR120B, TYR251A, TYR251B, TYR285A, TYR285B, VAL252A, VAL252B, VAL270B, VAL288A, VAL288B, VAL4A, VAL4B, VAL82A, VAL82B
• A-D: ALA191D, ALA197D, ALA198D, ALA199D, ALA200D, ALA229A, ALA229D, ALA25D, ARG172D, ARG205D, ARG232A, ARG234A, ARG234D, ARG258A, ARG258D, ARG284A, ARG289A, ASN192D, ASN212A, ASN26D, ASN319A, ASP135D, ASP170D, ASP196D, ASP223D, ASP227D, ASP24D, ASP261A, ASP320A, CYS259A, GLN193D, GLN224D, GLN226D, GLN257A, GLN257D, GLU156A, GLU169D, GLU204A, GLU204D, GLU209A, GLU218D, GLU323A, GLY163D, GLY164D, GLY214A, GLY27D, GLY287A, HIS321A, ILE162D, ILE213A, ILE262A, LEU220D, LEU231A, LEU231D, LEU235A, LEU255A, LEU260A, LYS168D, LYS202D, LYS316A, LYS318A, MET230A, MET230D, MET317A, PHE167D, PHE201A, PHE201D, PHE207A, PHE286A, PHE28D, PRO219D, PRO221D, PRO225D, PRO238A, SER166D, SER183A, SER184A, SER194D, SER208A, SER233A, SER233D, SER236A, SER256A, SER315A, THR165D, THR186A, THR211A, TRP139D, TRP210A, TRP215A, TRP314A, TYR133D, TYR195D, TYR206D, TYR228D, TYR285A, VAL237A, VAL239A, VAL288A
• A-G: ALA249A, ALA249G, ALA373A, ALA373G, ALA57A, ALA57G, ARG65A, ARG65G, ASN26A, ASN26G, ASP223A, ASP223G, ASP53A, ASP53G, GLN224A, GLN224G, GLN226A, GLN226G, GLN250A, GLN250G, GLN257A, GLN257G, GLU375A, GLU375G, GLY247A, GLY371A, GLY371G, GLY61A, GLY61G, HIS59A, HIS59G, HIS89A, HIS89G, ILE66A, ILE66G, ILE67A, LEU254A, LEU254G, LEU255G, LEU55A, LEU55G, LEU58A, LEU58G, LYS246A, LYS246G, LYS64A, LYS64G, LYS87A, LYS87G, PHE222A, PHE222G, PHE286A, PHE286G, PHE62A, PHE62G, PHE69A, PHE69G, PRO221A, PRO221G, PRO225A, PRO225G, PRO248A, PRO248G, PRO253A, PRO253G, PRO56A, PRO56G, PRO68A, PRO68G, SER256A, SER256G, SER372A, SER372G, THR63A, THR63G, TRP369A, TRP369G, TRP54A, TRP54G, TRP88A, TRP88G, TYR251A, TYR251G, TYR31A, TYR31G, TYR374A, TYR374G, VAL252A, VAL252G, VAL60A, VAL60G
• A-H: ALA191A, ALA197A, ALA198A, ALA199A, ALA200A, ALA229A, ALA229H, ALA25A, ARG172A, ARG205A, ARG232H, ARG234A, ARG234H, ARG258A, ARG258H, ARG284H, ARG289H, ASN192A, ASN212H, ASN244A, ASN26A, ASN319H, ASP135A, ASP170A, ASP196A, ASP223A, ASP227A, ASP24A, ASP261H, ASP320H, GLN193A, GLN224A, GLN226A, GLN257A, GLN257H, GLU169A, GLU204A, GLU204H, GLU209H, GLU218A, GLU323H, GLY163A, GLY164A, GLY214H, GLY27A, GLY287H, HIS321H, ILE162A, ILE213H, ILE262H, LEU220A, LEU231A, LEU231H, LEU235H, LEU255H, LEU260H, LYS168A, LYS202A, LYS316H, LYS318H, MET230A, MET230H, MET317H, PHE167A, PHE201A, PHE201H, PHE207H, PHE286H, PHE28A, PRO137A, PRO219A, PRO221A, PRO225A, PRO238H, SER136A, SER166A, SER183H, SER184H, SER194A, SER208H, SER233A, SER233H, SER236H, SER256H, SER315H, THR165A, THR186H, THR211H, TRP139A, TRP210H, TRP215H, TRP314H, TYR133A, TYR195A, TYR206A, TYR228A, TYR285H, VAL237H, VAL239H, VAL288H
• B-C: ALA191B, ALA197B, ALA198B, ALA199B, ALA200B, ALA229B, ALA229C, ALA25B, ARG172B, ARG205B, ARG232C, ARG234B, ARG234C, ARG258B, ARG258C, ARG284C, ARG289C, ASN192B, ASN212C, ASN244B, ASN26B, ASN319C, ASP135B, ASP170B, ASP196B, ASP223B, ASP227B, ASP24B, ASP261C, ASP320C, GLN193B, GLN224B, GLN226B, GLN257B, GLN257C, GLU169B, GLU204B, GLU204C, GLU209C, GLU218B, GLU323C, GLY163B, GLY164B, GLY214C, GLY27B, GLY287C, HIS321C, ILE162B, ILE213C, ILE262C, LEU220B, LEU231B, LEU231C, LEU235C, LEU255C, LEU260C, LYS168B, LYS202B, LYS316C, LYS318C, MET230B, MET230C, MET317C, PHE167B, PHE201B, PHE201C, PHE207C, PHE286C, PHE28B, PRO219B, PRO221B, PRO225B, PRO238C, SER166B, SER183C, SER184C, SER194B, SER208C, SER233B, SER233C, SER236C, SER256C, SER315C, THR165B, THR186C, THR211C, TRP139B, TRP203B, TRP210C, TRP215C, TRP314C, TYR133B, TYR195B, TYR206B, TYR228B, TYR285C, VAL237C, VAL239C, VAL288C
• B-D: ALA249B, ALA249D, ALA373B, ALA373D, ALA57B, ALA57D, ARG65B, ARG65D, ASN26B, ASN26D, ASP223B, ASP223D, ASP53B, ASP53D, GLN224B, GLN224D, GLN226B, GLN226D, GLN250B, GLN250D, GLN257B, GLN257D, GLU375B, GLU375D, GLY371B, GLY371D, GLY376D, GLY61B, GLY61D, HIS377D, HIS59B, HIS59D, HIS89B, HIS89D, ILE66B, ILE66D, ILE67B, ILE67D, LEU254B, LEU254D, LEU255D, LEU282D, LEU55B, LEU55D, LEU58B, LEU58D, LEU70B, LEU71B, LYS246B, LYS246D, LYS64B, LYS64D, LYS73B, LYS87B, LYS87D, PHE222B, PHE222D, PHE286B, PHE286D, PHE62B, PHE62D, PHE69B, PHE69D, PRO221B, PRO221D, PRO225B, PRO225D, PRO248B, PRO248D, PRO253B, PRO253D, PRO56B, PRO56D, PRO68B, PRO68D, SER256B, SER256D, SER372B, SER372D, THR63B, THR63D, TRP369B, TRP369D, TRP54B, TRP54D, TRP88B, TRP88D, TYR251B, TYR251D, TYR31B, TYR31D, TYR374B, TYR374D, VAL252B, VAL252D, VAL60B, VAL60D
• B-G: ALA191G, ALA197G, ALA198G, ALA199G, ALA200G, ALA229B, ALA229G, ALA25G, ALA290B, ARG172G, ARG205G, ARG232B, ARG234B, ARG234G, ARG258B, ARG258G, ARG284B, ARG289B, ASN192G, ASN212B, ASN26G, ASN319B, ASP170G, ASP196G, ASP223G, ASP227G, ASP24G, ASP261B, ASP320B, CYS259B, GLN193G, GLN224G, GLN226G, GLN257B, GLN257G, GLU156B, GLU169G, GLU204B, GLU204G, GLU209B, GLU218G, GLU323B, GLY163G, GLY164G, GLY214B, GLY27G, GLY287B, HIS321B, ILE162G, ILE213B, ILE262B, LEU220G, LEU231B, LEU231G, LEU235B, LEU255B, LEU260B, LYS168G, LYS202G, LYS316B, LYS318B, MET230B, MET230G, MET317B, PHE167G, PHE201B, PHE201G, PHE207B, PHE286B, PHE28G, PRO219G, PRO221G, PRO225G, PRO238B, SER166G, SER183B, SER184B, SER194G, SER208B, SER233B, SER233G, SER236B, SER256B, SER315B, THR165G, THR186B, THR211B, TRP210B, TRP215B, TRP314B, TYR133G, TYR195G, TYR206G, TYR228G, TYR285B, VAL237B, VAL239B, VAL288B
• C-D: ALA104C, ALA104D, ALA105C, ALA105D, ALA107C, ALA107D, ALA108C, ALA108D, ALA249C, ALA249D, ALA283C, ALA283D, ALA2D, ALA307C, ALA309C, ALA309D, ALA75C, ALA75D, ARG119C, ARG119D, ARG121C, ARG121D, ARG258C, ARG258D, ARG277C, ARG277D, ARG284C, ARG284D, ARG78C, ARG78D, ARG83C, ARG83D, ASN271C, ASN271D, ASP109C, ASP109D, ASP274C, ASP274D, ASP278C, ASP278D, CYS110C, CYS110D, CYS113C, CYS113D, CYS279C, CYS279D, CYS310C, CYS310D, GLN250C, GLN250D, GLN257C, GLN257D, GLN281C, GLN281D, GLN74C, GLN74D, GLN86C, GLN86D, GLU114C, GLU114D, GLU275C, GLU275D, GLY117C, GLY117D, GLY118C, GLY118D, GLY247C, GLY247D, GLY287C, GLY287D, GLY76C, GLY76D, HIS321C, HIS321D, LEU100C, LEU100D, LEU115C, LEU115D, LEU255C, LEU255D, LEU282C, LEU282D, LEU311C, LEU311D, LEU3C, LEU3D, LEU79C, LEU79D, LEU81C, LEU81D, LYS106C, LYS316C, LYS316D, LYS351C, LYS353C, LYS353D, LYS87C, LYS87D, PHE276C, PHE276D, PHE286C, PHE286D, PRO248C, PRO248D, PRO253C, PRO253D, PRO312C, PRO312D, PRO313C, PRO313D, SER111C, SER256C, SER256D, SER315C, SER315D, SER77C, SER77D, SER80C, SER80D, THR101C, THR101D, THR84C, THR84D, TRP116C, TRP116D, TRP314C, TRP314D, TYR120C, TYR120D, TYR251C, TYR251D, TYR285C, TYR285D, VAL252C, VAL252D, VAL288C, VAL288D, VAL4C, VAL4D, VAL82C, VAL82D
• C-E: ALA249C, ALA249E, ALA373C, ALA373E, ALA57C, ALA57E, ARG65C, ARG65E, ASN26C, ASN26E, ASP223C, ASP223E, ASP53C, ASP53E, GLN224C, GLN224E, GLN226C, GLN226E, GLN250C, GLN250E, GLN257C, GLN257E, GLU375C, GLU375E, GLY371C, GLY371E, GLY61C, GLY61E, HIS59C, HIS59E, HIS89C, HIS89E, ILE66C, ILE66E, LEU254C, LEU254E, LEU55C, LEU55E, LEU58C, LEU58E, LYS246C, LYS246E, LYS64C, LYS64E, LYS87C, LYS87E, PHE222C, PHE222E, PHE286C, PHE286E, PHE62C, PHE62E, PHE69C, PHE69E, PRO221C, PRO221E, PRO225C, PRO225E, PRO248C, PRO248E, PRO253C, PRO253E, PRO56C, PRO56E, PRO68C, PRO68E, SER256C, SER256E, SER372C, SER372E, THR63C, THR63E, TRP369C, TRP369E, TRP54C, TRP54E, TRP88C, TRP88E, TYR251C, TYR251E, TYR31C, TYR31E, TYR374C, TYR374E, VAL252C, VAL252E, VAL60C, VAL60E
• C-F: ALA191C, ALA197C, ALA198C, ALA199C, ALA200C, ALA229C, ALA229F, ALA25C, ALA283F, ARG172C, ARG205C, ARG232F, ARG234C, ARG234F, ARG258F, ARG284F, ARG289F, ASN192C, ASN212F, ASN26C, ASN319F, ASP170C, ASP196C, ASP223C, ASP227C, ASP24C, ASP261F, ASP320F, CYS259F, GLN193C, GLN224C, GLN226C, GLN257C, GLN257F, GLU169C, GLU204C, GLU204F, GLU209F, GLU218C, GLU323F, GLY163C, GLY164C, GLY214F, GLY27C, GLY287F, HIS321F, ILE162C, ILE213F, ILE262F, LEU220C, LEU231C, LEU231F, LEU235F, LEU255F, LEU260F, LYS168C, LYS202C, LYS316F, LYS318F, MET230C, MET230F, MET317F, PHE167C, PHE201C, PHE201F, PHE207F, PHE286F, PHE28C, PRO219C, PRO221C, PRO225C, PRO238F, SER166C, SER183F, SER184F, SER194C, SER208F, SER233C, SER233F, SER236F, SER256F, SER315F, THR165C, THR186F, THR211F, TRP210F, TRP215F, TRP314F, TYR133C, TYR195C, TYR206C, TYR228C, TYR285F, VAL237F, VAL239F, VAL288F
• D-E: ALA191E, ALA197E, ALA198E, ALA199E, ALA200E, ALA229D, ALA229E, ALA25E, ARG172E, ARG205E, ARG232D, ARG234D, ARG234E, ARG258D, ARG258E, ARG284D, ARG289D, ASN192E, ASN212D, ASN26E, ASN319D, ASP135E, ASP170E, ASP196E, ASP223E, ASP227E, ASP24E, ASP261D, ASP320D, GLN193E, GLN224E, GLN226E, GLN257D, GLN257E, GLU169E, GLU204D, GLU204E, GLU209D, GLU218E, GLU323D, GLY163E, GLY164E, GLY214D, GLY27E, GLY287D, HIS321D, ILE162E, ILE213D, ILE262D, LEU220E, LEU231D, LEU231E, LEU235D, LEU255D, LEU260D, LYS168E, LYS202E, LYS316D, LYS318D, MET230E, MET317D, PHE167E, PHE201D, PHE201E, PHE207D, PHE286D, PHE28E, PRO219E, PRO221E, PRO225E, PRO238D, SER166E, SER183D, SER184D, SER194E, SER208D, SER233D, SER233E, SER236D, SER256D, SER315D, THR165E, THR186D, THR211D, TRP210D, TRP215D, TRP314D, TYR133E, TYR195E, TYR206E, TYR228E, TYR285D, VAL237D, VAL239D, VAL288D
• E-F: ALA104E, ALA104F, ALA105E, ALA105F, ALA107E, ALA107F, ALA108E, ALA108F, ALA249E, ALA249F, ALA283E, ALA283F, ALA307F, ALA309E, ALA309F, ALA75E, ALA75F, ARG119E, ARG119F, ARG121E, ARG121F, ARG258E, ARG258F, ARG277E, ARG277F, ARG284E, ARG284F, ARG78E, ARG78F, ARG83E, ARG83F, ASN271E, ASN271F, ASP109E, ASP109F, ASP274E, ASP274F, ASP278E, ASP278F, CYS110E, CYS110F, CYS113E, CYS113F, CYS279E, CYS279F, CYS310E, CYS310F, GLN250E, GLN250F, GLN257E, GLN257F, GLN281E, GLN281F, GLN74E, GLN74F, GLN86E, GLN86F, GLU114E, GLU114F, GLU275E, GLU275F, GLY117E, GLY117F, GLY118E, GLY118F, GLY247E, GLY247F, GLY287E, GLY287F, GLY76E, GLY76F, HIS321E, HIS321F, LEU100E, LEU100F, LEU115E, LEU115F, LEU255E, LEU255F, LEU282E, LEU282F, LEU311E, LEU311F, LEU3E, LEU3F, LEU79E, LEU79F, LEU81E, LEU81F, LYS106E, LYS316E, LYS316F, LYS351E, LYS351F, LYS353E, LYS353F, LYS87E, LYS87F, PHE276E, PHE276F, PHE286E, PHE286F, PRO248E, PRO248F, PRO253E, PRO253F, PRO312E, PRO312F, PRO313E, PRO313F, SER111F, SER256E, SER256F, SER315E, SER315F, SER77E, SER77F, SER80E, SER80F, THR101E, THR101F, THR84E, THR84F, TRP116E, TRP116F, TRP314E, TRP314F, TYR120E, TYR120F, TYR251E, TYR251F, TYR285E, TYR285F, VAL252E, VAL252F, VAL288F, VAL4E, VAL4F, VAL82E, VAL82F
• E-H: ALA191H, ALA197H, ALA198H, ALA199H, ALA200H, ALA229E, ALA229H, ALA25H, ARG172H, ARG205E, ARG205H, ARG232E, ARG234E, ARG234H, ARG258E, ARG284E, ARG289E, ASN192H, ASN212E, ASN26H, ASN319E, ASP135H, ASP170H, ASP196H, ASP223H, ASP227H, ASP24H, ASP261E, ASP320E, CYS259E, GLN193H, GLN224H, GLN226H, GLN257E, GLN257H, GLU156E, GLU169H, GLU204E, GLU204H, GLU209E, GLU218H, GLU323E, GLY163H, GLY164H, GLY214E, GLY27H, GLY287E, HIS321E, ILE162H, ILE213E, ILE262E, LEU220H, LEU231E, LEU231H, LEU235E, LEU255E, LEU260E, LYS168H, LYS202H, LYS316E, LYS318E, MET230E, MET230H, MET317E, PHE167H, PHE201E, PHE201H, PHE207E, PHE286E, PHE28H, PRO219H, PRO221H, PRO225H, PRO238E, SER166H, SER184E, SER194H, SER208E, SER233E, SER233H, SER236E, SER256E, SER315E, THR165H, THR186E, THR211E, TRP203H, TRP210E, TRP215E, TRP314E, TYR133H, TYR195H, TYR206E, TYR206H, TYR228H, TYR285E, VAL237E, VAL239E, VAL288E
• F-G: ALA191F, ALA197F, ALA198F, ALA199F, ALA200F, ALA229F, ALA229G, ALA25F, ARG172F, ARG205F, ARG232G, ARG234F, ARG234G, ARG258G, ARG284G, ARG289G, ASN192F, ASN212G, ASN26F, ASN319G, ASP135F, ASP170F, ASP196F, ASP223F, ASP227F, ASP24F, ASP261G, ASP320G, GLN193F, GLN224F, GLN226F, GLN257F, GLN257G, GLU169F, GLU204F, GLU204G, GLU209G, GLU218F, GLU323G, GLY163F, GLY164F, GLY214G, GLY27F, GLY287G, HIS321G, ILE162F, ILE213G, ILE262G, LEU220F, LEU231F, LEU231G, LEU235G, LEU255G, LEU260G, LYS168F, LYS202F, LYS316G, LYS318G, MET230F, MET230G, MET317G, PHE167F, PHE201F, PHE201G, PHE207G, PHE286G, PHE28F, PRO219F, PRO221F, PRO225F, PRO238G, SER134F, SER166F, SER183G, SER184G, SER194F, SER208G, SER233F, SER233G, SER236G, SER256G, SER315G, THR165F, THR186G, THR211G, TRP139F, TRP203F, TRP210G, TRP215G, TRP314G, TYR133F, TYR195F, TYR206F, TYR228F, TYR285G, VAL237G, VAL239G, VAL288G
• F-H: ALA249F, ALA249H, ALA373F, ALA373H, ALA57F, ALA57H, ARG65F, ARG65H, ASN26F, ASN26H, ASP223F, ASP223H, ASP370F, ASP53F, ASP53H, GLN224F, GLN224H, GLN226F, GLN226H, GLN250F, GLN250H, GLN257F, GLN257H, GLU375F, GLU375H, GLY247F, GLY247H, GLY371F, GLY371H, GLY61F, GLY61H, HIS59F, HIS59H, HIS89F, HIS89H, ILE66F, ILE66H, LEU254F, LEU254H, LEU55F, LEU55H, LEU58F, LEU58H, LYS246F, LYS246H, LYS64F, LYS64H, LYS87F, LYS87H, PHE222F, PHE222H, PHE286F, PHE286H, PHE62F, PHE62H, PHE69F, PRO221F, PRO221H, PRO225F, PRO225H, PRO248F, PRO248H, PRO253F, PRO253H, PRO56F, PRO56H, PRO68F, PRO68H, SER256F, SER256H, SER372F, SER372H, THR63F, THR63H, TRP369F, TRP369H, TRP54F, TRP54H, TRP88F, TRP88H, TYR251F, TYR251H, TYR31F, TYR31H, TYR374F, TYR374H, VAL252F, VAL252H, VAL60F, VAL60H
• G-H: ALA104G, ALA104H, ALA105G, ALA105H, ALA107G, ALA107H, ALA108G, ALA108H, ALA249G, ALA249H, ALA283G, ALA283H, ALA2G, ALA2H, ALA309G, ALA309H, ALA75G, ALA75H, ARG119G, ARG119H, ARG121G, ARG121H, ARG258G, ARG258H, ARG277G, ARG277H, ARG284G, ARG284H, ARG78G, ARG78H, ARG83G, ARG83H, ASN271G, ASN271H, ASP109G, ASP109H, ASP274G, ASP274H, ASP278G, ASP278H, CYS110G, CYS110H, CYS113G, CYS113H, CYS279G, CYS279H, CYS310G, CYS310H, GLN250G, GLN250H, GLN257G, GLN257H, GLN281G, GLN281H, GLN74G, GLN74H, GLN86G, GLN86H, GLU114G, GLU114H, GLU122G, GLU275G, GLU275H, GLY117G, GLY117H, GLY118G, GLY118H, GLY247G, GLY247H, GLY287G, GLY287H, GLY76G, GLY76H, HIS321G, LEU100G, LEU100H, LEU115G, LEU115H, LEU255G, LEU255H, LEU282G, LEU282H, LEU311G, LEU311H, LEU3G, LEU3H, LEU79G, LEU79H, LEU81G, LEU81H, LYS106H, LYS316G, LYS316H, LYS351G, LYS351H, LYS353G, LYS353H, LYS87G, LYS87H, PHE276G, PHE276H, PHE286G, PHE286H, PRO248G, PRO248H, PRO253G, PRO253H, PRO312G, PRO312H, PRO313G, PRO313H, SER111G, SER111H, SER256G, SER256H, SER315G, SER315H, SER77G, SER77H, SER80G, SER80H, THR101G, THR101H, THR84G, THR84H, TRP116G, TRP116H, TRP314G, TRP314H, TYR120G, TYR120H, TYR251G, TYR251H, TYR285G, TYR285H, VAL252G, VAL252H, VAL270G, VAL288G, VAL288H, VAL4G, VAL4H, VAL82G, VAL82H