2GFB

crystal structure of a catalytic fab having esterase-like activity

• Total interactions analyzed: 120
• Total true interactions: 30
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 190
  • Norm. En. per Res.: -3.0084
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-39.9191	-26.5084	-480.419	-546.8464	192	33	11	19084	2	20	23
B-C	0.0	0.0	-5.4821	-5.4821	12	0	0	397	0	2	1
B-D	-33.6955	-4.5652	-96.9482	-135.209	85	8	1	5243	1	13	18
B-E	0.0	0.0	-9.4057	-9.4057	18	0	0	569	0	0	0
B-F	0.0	-0.8487	-2.2235	-3.0723	17	3	0	501	0	3	4
C-D	-44.4984	-27.7258	-499.371	-571.5951	190	29	11	19069	2	20	23
C-H	0.0	-0.7982	-10.3852	-11.1834	18	0	0	522	0	12	12
C-M	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	1	1
D-F	0.0	0.0	-28.086	-28.086	53	2	0	1752	0	5	6
D-G	0.0	0.0	-0.4879	-0.4879	8	0	0	84	0	0	0
D-H	0.0	0.0	-0.5069	-0.5069	8	0	0	110	0	2	0
E-F	-40.7293	-26.4023	-498.296	-565.4276	191	30	11	19103	2	19	22
F-G	0.0	0.0	-3.5162	-3.5162	10	0	0	303	0	2	1
F-H	-25.067	-1.6418	-71.0387	-97.7475	75	9	1	4254	0	12	17
G-H	-41.6737	-27.2303	-488.469	-557.373	191	28	11	19022	2	20	23
I-J	-43.3256	-26.5008	-494.284	-564.1104	191	32	11	18993	1	19	23
J-K	0.0	0.0	-3.3243	-3.3243	10	0	0	309	0	2	1
J-L	-32.3944	-3.5595	-87.6287	-123.5826	79	5	1	4725	1	12	18
J-M	0.0	0.0	-12.4962	-12.4962	21	0	0	723	0	0	0
J-N	0.0	-2.1215	-11.2708	-13.3923	16	0	0	602	1	4	5
K-L	-27.5371	-27.3626	-477.44	-532.3397	193	28	11	18839	2	20	22
K-O	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
K-P	0.0	0.0	-3.5519	-3.5519	17	0	0	270	0	9	8
L-N	0.0	0.7203	-35.2752	-34.5549	52	3	0	1969	0	6	7
L-O	0.0	0.0	-0.4843	-0.4843	9	0	0	113	0	0	0
L-P	0.0	0.0	-1.7967	-1.7967	8	0	0	205	0	2	1
M-N	-39.6415	-28.5824	-473.829	-542.0529	192	30	12	18955	2	20	22
N-O	0.0	0.0	-2.227	-2.227	9	0	0	213	0	2	1
N-P	-9.4644	-1.0388	-62.1021	-72.6053	79	9	1	3924	0	9	14
O-P	-32.2	-28.0087	-484.011	-544.2196	193	32	12	18998	1	20	23

Interface residues

• A-B: ALA101B, ALA125B, ALA130A, ALA176B, ALA40B, ALA49B, ALA60B, ALA93B, ARG100B, ARG211A, ARG226B, ARG38B, ARG46A, ARG94B, ASN137A, ASN138A, ASN157A, ASN161A, ASN210A, ASP130B, ASP165A, ASP167A, ASP170A, ASP1B, ASP41A, ASP55A, ASP61B, ASP85A, ASP96B, CYS128B, CYS134A, CYS142B, CYS194A, CYS214A, CYS88A, CYS92B, GLN105B, GLN124A, GLN179B, GLN1A, GLN37A, GLN38A, GLN39B, GLN90A, GLU123A, GLU213A, GLU42B, GLU46B, GLU6B, GLY100A, GLY100B, GLY101A, GLY104B, GLY106B, GLY129A, GLY129B, GLY135B, GLY141B, GLY158A, GLY169B, GLY227B, GLY42A, GLY44B, GLY57A, GLY95B, GLY99A, GLY99B, HIS172B, HIS35B, ILE117A, ILE223B, ILE44A, ILE51B, ILE57B, LEU124B, LEU125A, LEU136A, LEU140B, LEU143B, LEU160A, LEU178B, LEU179A, LEU181A, LEU184B, LEU187B, LEU36A, LEU45B, LEU47A, LEU89A, LYS103A, LYS142A, LYS145B, LYS169A, LYS207A, LYS221B, LYS222B, LYS39A, LYS43B, LYS45A, LYS64B, MET175A, MET34B, MET89B, PHE118A, PHE135A, PHE139A, PHE174B, PHE209A, PHE98A, PRO119A, PRO120A, PRO123B, PRO126B, PRO175B, PRO40A, PRO95A, SER100B, SER116A, SER120B, SER121A, SER122A, SER127A, SER131A, SER137B, SER162A, SER167B, SER168B, SER174A, SER176A, SER177A, SER180B, SER188B, SER189B, SER190B, SER208A, SER34A, SER56A, SER93A, SER94A, THR114A, THR126A, THR133B, THR134B, THR139B, THR164A, THR172A, THR173B, THR178A, THR180A, THR186B, THR192B, THR43A, THR56B, THR62B, THR97A, TRP103B, TRP157B, TRP163A, TRP199B, TRP35A, TRP36B, TRP47B, TYR122B, TYR173A, TYR185B, TYR186A, TYR49A, TYR50B, TYR58B, TYR59B, TYR86A, TYR87A, TYR91A, TYR91B, TYR96A, TYR97B, TYR98B, VAL115A, VAL121B, VAL127B, VAL132A, VAL133A, VAL138B, VAL144B, VAL159A, VAL171B, VAL177B, VAL191B, VAL206A, VAL37B, VAL48B, VAL58A
• B-C: ASN73B, ASP72B, GLN124C, GLU123C, LEU125C, LYS75B, PRO74B, SER121C, SER122C, SER127C, SER30B, THR126C
• B-D: ALA101B, ALA118D, ALA211D, ALA214D, ALA23B, ALA24B, ARG18D, ASN162B, ASN209B, ASN73B, ASN76B, ASP220B, ASP220D, ASP72B, ASP72D, CYS22B, GLN13D, GLN203B, GLN81D, GLU6B, GLY100B, GLY146D, GLY15D, GLY16D, GLY26B, HIS212D, ILE205B, LEU143D, LEU166B, LEU184D, LEU4B, LYS145D, LYS19B, LYS19D, LYS218B, LYS218D, LYS221D, LYS222B, LYS222D, LYS3B, LYS75B, LYS75D, PHE148D, PHE27B, PHE29B, PHE79B, PHE79D, PRO119D, PRO123D, PRO213D, PRO74B, PRO74D, SER120D, SER163B, SER165B, SER17D, SER202B, SER204B, SER215D, SER216B, SER216D, SER21B, SER21D, SER25B, SER30B, SER7B, THR117D, THR206B, THR217B, THR217D, THR28B, THR77B, THR77D, TRP103B, TRP157B, TYR102B, TYR122D, TYR147D, VAL121D, VAL12D, VAL144D, VAL210D, VAL219B, VAL219D, VAL5B
• B-E: ARG155E, ARG188E, ASN157E, ASP184E, GLN156E, GLN203B, GLU185E, GLY128E, HIS189E, LEU181E, SER136B, SER137B, SER195B, SER196B, SER202B, THR182E, THR194B, THR198B
• B-F: ALA113F, ARG100B, ARG66F, ARG83F, ASP1B, GLN13F, GLU85F, GLY15F, GLY26B, LEU82F, PRO14F, SER82F, SER84F, TYR102B, TYR98B, VAL111F, VAL2B
• C-D: ALA125D, ALA130C, ALA176D, ALA49D, ALA60D, ALA92C, ALA93D, ARG100D, ARG211C, ARG226D, ARG38D, ARG46C, ARG94D, ASN137C, ASN138C, ASN157C, ASN161C, ASN210C, ASP130D, ASP165C, ASP167C, ASP170C, ASP41C, ASP55C, ASP61D, ASP85C, ASP96D, CYS128D, CYS134C, CYS142D, CYS194C, CYS214C, CYS88C, CYS92D, GLN105D, GLN124C, GLN179D, GLN1C, GLN37C, GLN38C, GLN39D, GLN90C, GLU123C, GLU213C, GLU42D, GLU46D, GLU6D, GLY100C, GLY100D, GLY101C, GLY104D, GLY106D, GLY128C, GLY129C, GLY129D, GLY135D, GLY141D, GLY158C, GLY169D, GLY227D, GLY42C, GLY44D, GLY57C, GLY95D, GLY99C, GLY99D, HIS172D, HIS35D, ILE117C, ILE223D, ILE44C, ILE51D, ILE57D, LEU124D, LEU125C, LEU136C, LEU140D, LEU143D, LEU160C, LEU178D, LEU179C, LEU181C, LEU184D, LEU187D, LEU36C, LEU45D, LEU47C, LEU4D, LEU89C, LYS103C, LYS142C, LYS145D, LYS169C, LYS207C, LYS221D, LYS222D, LYS39C, LYS43D, LYS45C, LYS64D, MET175C, MET34D, MET89D, PHE118C, PHE135C, PHE139C, PHE174D, PHE209C, PHE98C, PRO119C, PRO120C, PRO123D, PRO126D, PRO175D, PRO40C, PRO95C, SER100D, SER116C, SER120D, SER121C, SER122C, SER127C, SER131C, SER137D, SER162C, SER167D, SER168D, SER174C, SER176C, SER177C, SER180D, SER188D, SER189D, SER190D, SER208C, SER34C, SER56C, SER93C, SER94C, THR114C, THR126C, THR133D, THR134D, THR139D, THR164C, THR172C, THR173D, THR178C, THR180C, THR186D, THR192D, THR43C, THR56D, THR62D, THR97C, TRP157D, TRP163C, TRP199D, TRP35C, TRP36D, TRP47D, TYR122D, TYR173C, TYR185D, TYR186C, TYR49C, TYR50D, TYR58D, TYR59D, TYR86C, TYR87C, TYR91C, TYR91D, TYR96C, TYR97D, TYR98D, VAL115C, VAL121D, VAL127D, VAL132C, VAL133C, VAL138D, VAL144D, VAL159C, VAL171D, VAL177D, VAL191D, VAL206C, VAL37D, VAL48D
• C-H: ARG61C, ARG66H, ARG83H, ASP55C, ASP61H, GLU81C, GLU85H, GLY57C, GLY65H, LYS45C, LYS60C, LYS64H, PRO59C, SER56C, SER82H, SER84H, THR62H, VAL58C
• C-M: LYS147C, LYS199M
• D-F: ALA101D, ALA113F, ALA118F, ALA214F, ALA23D, ARG100D, ARG18F, ARG66F, ARG83F, ASN162D, ASN209D, ASN76D, ASP1D, ASP220D, GLN13F, GLN203D, GLN81F, GLY10F, GLY15F, GLY164D, GLY16F, GLY26D, GLY65F, LEU11F, LEU166D, LEU82F, LYS115F, LYS19F, LYS218D, LYS3D, MET82F, PRO213F, SER163D, SER165D, SER17F, SER204D, SER215F, SER216F, SER25D, SER70F, SER82F, THR116F, THR117F, THR156D, THR206D, THR217F, THR68F, THR82F, TRP103D, TRP157D, TYR102D, VAL12F, VAL5D
• D-G: ARG188G, ASP184G, GLU185G, GLY128G, SER136D, SER195D, SER196D, THR182G
• D-H: ARG100D, ASP1D, GLN13H, GLY15H, GLY16H, PRO14H, SER82H, TYR98D
• E-F: ALA101F, ALA125F, ALA130E, ALA176F, ALA49F, ALA60F, ALA92E, ALA93F, ARG100F, ARG211E, ARG226F, ARG38F, ARG46E, ARG94F, ASN137E, ASN138E, ASN157E, ASN161E, ASN210E, ASP130F, ASP165E, ASP167E, ASP170E, ASP41E, ASP55E, ASP61F, ASP85E, ASP96F, CYS128F, CYS134E, CYS142F, CYS194E, CYS214E, CYS88E, CYS92F, GLN105F, GLN124E, GLN179F, GLN1E, GLN37E, GLN38E, GLN39F, GLN90E, GLU123E, GLU213E, GLU42F, GLU46F, GLU6F, GLY100E, GLY100F, GLY101E, GLY104F, GLY106F, GLY129E, GLY129F, GLY135F, GLY141F, GLY158E, GLY169F, GLY227F, GLY42E, GLY44F, GLY57E, GLY95F, GLY99E, GLY99F, HIS172F, HIS35F, ILE117E, ILE223F, ILE44E, ILE51F, ILE57F, LEU124F, LEU125E, LEU136E, LEU140F, LEU143F, LEU160E, LEU178F, LEU179E, LEU181E, LEU184F, LEU187F, LEU36E, LEU45F, LEU47E, LEU4F, LEU89E, LYS103E, LYS142E, LYS145F, LYS169E, LYS207E, LYS221F, LYS222F, LYS39E, LYS43F, LYS45E, LYS64F, MET175E, MET34F, MET89F, PHE118E, PHE135E, PHE139E, PHE174F, PHE209E, PHE98E, PRO119E, PRO120E, PRO123F, PRO126F, PRO175F, PRO40E, PRO95E, SER100F, SER116E, SER120F, SER121E, SER122E, SER127E, SER131E, SER137F, SER162E, SER167F, SER168F, SER174E, SER176E, SER177E, SER180F, SER188F, SER189F, SER190F, SER208E, SER34E, SER56E, SER93E, SER94E, THR114E, THR126E, THR133F, THR134F, THR139F, THR164E, THR172E, THR173F, THR178E, THR180E, THR186F, THR192F, THR43E, THR56F, THR62F, THR97E, TRP103F, TRP157F, TRP163E, TRP199F, TRP35E, TRP36F, TRP47F, TYR122F, TYR173E, TYR185F, TYR186E, TYR49E, TYR50F, TYR58F, TYR59F, TYR86E, TYR87E, TYR91E, TYR91F, TYR96E, TYR97F, TYR98F, VAL115E, VAL121F, VAL127F, VAL132E, VAL133E, VAL138F, VAL144F, VAL159E, VAL171F, VAL177F, VAL191F, VAL206E, VAL37F, VAL48F
• F-G: ASN73F, ASP72F, GLN124G, GLU123G, LYS75F, PRO74F, SER121G, SER127G, SER30F, THR126G
• F-H: ALA101F, ALA118H, ALA211H, ALA214H, ALA23F, ALA24F, ARG18H, ASN162F, ASN209F, ASN73F, ASN76F, ASP220F, ASP220H, ASP72F, ASP72H, CYS22F, GLN13H, GLN203F, GLN81H, GLU6F, GLY100F, GLY146H, GLY15H, GLY16H, GLY26F, HIS212H, LEU166F, LEU184H, LEU4F, LYS145H, LYS19H, LYS218F, LYS218H, LYS221H, LYS3F, LYS75F, LYS75H, PHE148H, PHE27F, PHE29F, PHE79F, PHE79H, PRO119H, PRO123H, PRO213H, PRO74F, PRO74H, SER120H, SER163F, SER165F, SER17H, SER204F, SER215H, SER216F, SER216H, SER21F, SER21H, SER25F, SER30F, SER7F, THR116H, THR117H, THR206F, THR217F, THR217H, THR28F, THR77F, TRP103F, TYR102F, TYR122H, TYR147H, VAL121H, VAL12H, VAL219H, VAL5F
• G-H: ALA125H, ALA130G, ALA176H, ALA49H, ALA60H, ALA92G, ALA93H, ARG100H, ARG211G, ARG226H, ARG38H, ARG46G, ARG94H, ASN137G, ASN138G, ASN157G, ASN161G, ASN210G, ASP130H, ASP165G, ASP167G, ASP170G, ASP41G, ASP55G, ASP61H, ASP85G, ASP96H, CYS128H, CYS134G, CYS142H, CYS194G, CYS214G, CYS88G, CYS92H, GLN105H, GLN124G, GLN179H, GLN1G, GLN37G, GLN38G, GLN39H, GLN90G, GLU123G, GLU213G, GLU42H, GLU46H, GLU6H, GLY100G, GLY100H, GLY101G, GLY104H, GLY106H, GLY128G, GLY129G, GLY129H, GLY135H, GLY141H, GLY158G, GLY169H, GLY227H, GLY42G, GLY44H, GLY57G, GLY95H, GLY99G, GLY99H, HIS172H, HIS35H, ILE117G, ILE223H, ILE44G, ILE51H, ILE57H, LEU124H, LEU125G, LEU136G, LEU140H, LEU143H, LEU160G, LEU178H, LEU179G, LEU181G, LEU184H, LEU187H, LEU36G, LEU45H, LEU47G, LEU4H, LEU89G, LYS103G, LYS142G, LYS145H, LYS169G, LYS207G, LYS221H, LYS222H, LYS39G, LYS43H, LYS45G, LYS64H, MET175G, MET34H, MET89H, PHE118G, PHE135G, PHE139G, PHE174H, PHE209G, PHE98G, PRO119G, PRO120G, PRO123H, PRO126H, PRO175H, PRO40G, PRO95G, SER100H, SER116G, SER120H, SER121G, SER122G, SER127G, SER131G, SER137H, SER162G, SER167H, SER168H, SER174G, SER176G, SER177G, SER180H, SER188H, SER189H, SER190H, SER208G, SER34G, SER56G, SER93G, SER94G, THR114G, THR126G, THR133H, THR134H, THR139H, THR164G, THR172G, THR173H, THR178G, THR180G, THR186H, THR192H, THR43G, THR56H, THR62H, THR97G, TRP103H, TRP157H, TRP163G, TRP199H, TRP35G, TRP36H, TRP47H, TYR122H, TYR173G, TYR185H, TYR186G, TYR49G, TYR50H, TYR58H, TYR59H, TYR86G, TYR87G, TYR91G, TYR91H, TYR96G, TYR97H, TYR98H, VAL115G, VAL121H, VAL127H, VAL132G, VAL133G, VAL138H, VAL144H, VAL159G, VAL171H, VAL177H, VAL191H, VAL206G, VAL37H, VAL48H
• I-J: ALA125J, ALA130I, ALA176J, ALA49J, ALA60J, ALA93J, ARG100J, ARG211I, ARG226J, ARG38J, ARG46I, ARG94J, ASN137I, ASN138I, ASN157I, ASN161I, ASN210I, ASP130J, ASP165I, ASP167I, ASP170I, ASP41I, ASP55I, ASP61J, ASP85I, ASP96J, CYS128J, CYS134I, CYS142J, CYS194I, CYS214I, CYS88I, CYS92J, GLN105J, GLN124I, GLN179J, GLN1I, GLN37I, GLN38I, GLN39J, GLN90I, GLU123I, GLU213I, GLU42J, GLU46J, GLU6J, GLY100I, GLY100J, GLY101I, GLY104J, GLY106J, GLY129I, GLY129J, GLY135J, GLY141J, GLY158I, GLY169J, GLY227J, GLY42I, GLY44J, GLY57I, GLY95J, GLY99I, GLY99J, HIS172J, HIS35J, ILE117I, ILE223J, ILE44I, ILE48I, ILE51J, ILE57J, LEU124J, LEU125I, LEU136I, LEU140J, LEU143J, LEU160I, LEU178J, LEU179I, LEU181I, LEU184J, LEU187J, LEU36I, LEU45J, LEU47I, LEU4J, LEU89I, LYS103I, LYS142I, LYS145J, LYS169I, LYS207I, LYS221J, LYS222J, LYS39I, LYS43J, LYS45I, LYS64J, MET175I, MET34J, MET89J, PHE118I, PHE135I, PHE139I, PHE174J, PHE209I, PHE98I, PRO119I, PRO120I, PRO123J, PRO126J, PRO175J, PRO40I, PRO95I, SER100J, SER116I, SER120J, SER121I, SER122I, SER127I, SER131I, SER137J, SER162I, SER167J, SER168J, SER174I, SER176I, SER177I, SER180J, SER188J, SER189J, SER190J, SER208I, SER34I, SER56I, SER93I, SER94I, THR102I, THR114I, THR126I, THR133J, THR134J, THR139J, THR164I, THR172I, THR173J, THR178I, THR180I, THR186J, THR192J, THR43I, THR56J, THR62J, THR97I, TRP157J, TRP163I, TRP199J, TRP35I, TRP36J, TRP47J, TYR122J, TYR173I, TYR185J, TYR186I, TYR192I, TYR49I, TYR50J, TYR58J, TYR59J, TYR86I, TYR87I, TYR91I, TYR91J, TYR96I, TYR97J, TYR98J, VAL115I, VAL121J, VAL127J, VAL132I, VAL133I, VAL138J, VAL144J, VAL159I, VAL171J, VAL177J, VAL191J, VAL206I, VAL37J, VAL48J
• J-K: ASN73J, ASP72J, GLN124K, GLU123K, LYS75J, PRO74J, SER121K, SER127K, SER30J, THR126K
• J-L: ALA101J, ALA118L, ALA211L, ALA214L, ALA23J, ALA24J, ARG18L, ASN162J, ASN209J, ASN73J, ASN76J, ASP220J, ASP220L, ASP72J, ASP72L, CYS22J, GLN13L, GLN203J, GLN81L, GLU6J, GLY100J, GLY146L, GLY15L, GLY16L, GLY26J, HIS212L, ILE205J, LEU143L, LEU166J, LEU184L, LEU4J, LYS145L, LYS19J, LYS19L, LYS218J, LYS218L, LYS221L, LYS3J, LYS75J, LYS75L, PHE148L, PHE27J, PHE29J, PHE79J, PHE79L, PRO119L, PRO123L, PRO213L, PRO74J, PRO74L, SER120L, SER163J, SER165J, SER17L, SER202J, SER204J, SER215L, SER216J, SER216L, SER21J, SER21L, SER25J, SER30J, SER7J, THR117L, THR206J, THR217J, THR217L, THR28J, THR77J, TRP103J, TYR102J, TYR122L, TYR147L, VAL121L, VAL12L, VAL210L, VAL219L, VAL5J
• J-M: ARG155M, ARG188M, ASN157M, ASP184M, GLN156M, GLN203J, GLU185M, GLY128M, GLY158M, HIS189M, LEU181M, LYS183M, SER136J, SER137J, SER195J, SER196J, SER202J, THR182M, THR194J, THR198J, TYR186M
• J-N: ALA113N, ARG100J, ARG66N, ARG83N, ASP1J, GLU85N, GLY15N, GLY26J, LEU82N, PRO14N, SER82N, SER84N, TYR102J, TYR98J, VAL111N, VAL2J
• K-L: ALA125L, ALA130K, ALA176L, ALA49L, ALA60L, ALA92K, ALA93L, ARG100L, ARG211K, ARG226L, ARG38L, ARG46K, ARG94L, ASN137K, ASN138K, ASN157K, ASN161K, ASN210K, ASP130L, ASP165K, ASP167K, ASP170K, ASP41K, ASP55K, ASP61L, ASP85K, ASP96L, CYS128L, CYS134K, CYS142L, CYS194K, CYS214K, CYS88K, CYS92L, GLN105L, GLN124K, GLN179L, GLN1K, GLN37K, GLN38K, GLN39L, GLN90K, GLU123K, GLU213K, GLU42L, GLU46L, GLU6L, GLY100K, GLY100L, GLY101K, GLY104L, GLY106L, GLY128K, GLY129K, GLY129L, GLY135L, GLY141L, GLY158K, GLY169L, GLY227L, GLY42K, GLY44L, GLY57K, GLY95L, GLY99K, GLY99L, HIS172L, HIS35L, ILE117K, ILE223L, ILE44K, ILE48K, ILE51L, ILE57L, LEU124L, LEU125K, LEU136K, LEU140L, LEU143L, LEU160K, LEU178L, LEU179K, LEU181K, LEU184L, LEU187L, LEU36K, LEU45L, LEU47K, LEU4L, LEU89K, LYS103K, LYS142K, LYS145L, LYS169K, LYS207K, LYS221L, LYS222L, LYS39K, LYS43L, LYS45K, LYS64L, MET175K, MET34L, MET89L, PHE118K, PHE135K, PHE139K, PHE174L, PHE209K, PHE98K, PRO119K, PRO120K, PRO123L, PRO126L, PRO175L, PRO40K, PRO95K, SER100L, SER116K, SER120L, SER121K, SER122K, SER127K, SER131K, SER137L, SER162K, SER167L, SER168L, SER174K, SER176K, SER177K, SER180L, SER188L, SER189L, SER190L, SER208K, SER34K, SER56K, SER93K, SER94K, THR102K, THR114K, THR126K, THR133L, THR134L, THR139L, THR164K, THR172K, THR173L, THR178K, THR180K, THR186L, THR192L, THR43K, THR56L, THR62L, THR97K, TRP157L, TRP163K, TRP199L, TRP35K, TRP36L, TRP47L, TYR122L, TYR173K, TYR185L, TYR186K, TYR49K, TYR50L, TYR58L, TYR59L, TYR86K, TYR87K, TYR91K, TYR91L, TYR96K, TYR97L, TYR98L, VAL115K, VAL121L, VAL127L, VAL132K, VAL133K, VAL138L, VAL144L, VAL159K, VAL171L, VAL177L, VAL191L, VAL206K, VAL37L, VAL48L, VAL58K
• K-O: GLN1O, LYS60K
• K-P: ARG61K, ARG66P, ARG83P, ASP55K, ASP61P, GLU81K, GLU85P, GLY57K, LYS45K, LYS60K, LYS64P, PRO59K, SER56K, SER82P, SER84P, THR62P, VAL58K
• L-N: ALA101L, ALA113N, ALA118N, ALA214N, ALA23L, ARG100L, ARG18N, ARG66N, ASN162L, ASN209L, ASN76L, ASP1L, ASP220L, GLN13N, GLN203L, GLN81N, GLY10N, GLY15N, GLY164L, GLY16N, GLY26L, LEU11N, LEU166L, LEU82N, LYS115N, LYS19N, LYS218L, LYS3L, MET82N, PRO14N, PRO213N, SER163L, SER165L, SER17N, SER204L, SER215N, SER216N, SER25L, SER70N, SER82N, THR116N, THR117N, THR156L, THR206L, THR217N, THR68N, THR82N, TRP103L, TRP157L, TYR102L, VAL12N, VAL5L
• L-O: ARG188O, ASP184O, GLU185O, GLY128O, SER136L, SER195L, SER196L, THR182O, THR194L
• L-P: ARG100L, ASP1L, GLN13P, GLY15P, GLY16P, PRO14P, SER82P, TYR98L
• M-N: ALA101N, ALA125N, ALA130M, ALA176N, ALA49N, ALA60N, ALA93N, ARG100N, ARG211M, ARG226N, ARG38N, ARG46M, ARG94N, ASN137M, ASN138M, ASN157M, ASN161M, ASN210M, ASP130N, ASP165M, ASP167M, ASP170M, ASP41M, ASP55M, ASP61N, ASP85M, ASP96N, CYS128N, CYS134M, CYS142N, CYS194M, CYS214M, CYS88M, CYS92N, GLN105N, GLN124M, GLN179N, GLN1M, GLN37M, GLN38M, GLN39N, GLN90M, GLU123M, GLU213M, GLU42N, GLU46N, GLU6N, GLY100M, GLY100N, GLY101M, GLY104N, GLY106N, GLY128M, GLY129M, GLY129N, GLY135N, GLY141N, GLY158M, GLY169N, GLY227N, GLY42M, GLY44N, GLY57M, GLY95N, GLY99M, GLY99N, HIS172N, HIS35N, ILE117M, ILE223N, ILE44M, ILE51N, ILE57N, LEU124N, LEU125M, LEU136M, LEU140N, LEU143N, LEU160M, LEU178N, LEU179M, LEU181M, LEU184N, LEU187N, LEU36M, LEU45N, LEU47M, LEU4N, LEU89M, LYS103M, LYS142M, LYS145N, LYS169M, LYS207M, LYS221N, LYS222N, LYS39M, LYS43N, LYS45M, LYS64N, MET175M, MET34N, MET89N, PHE118M, PHE135M, PHE139M, PHE174N, PHE209M, PHE98M, PRO113M, PRO119M, PRO120M, PRO123N, PRO126N, PRO175N, PRO40M, PRO95M, SER100N, SER116M, SER120N, SER121M, SER122M, SER127M, SER131M, SER137N, SER162M, SER167N, SER168N, SER174M, SER176M, SER177M, SER180N, SER188N, SER189N, SER190N, SER208M, SER34M, SER56M, SER93M, SER94M, THR114M, THR126M, THR133N, THR134N, THR139N, THR164M, THR172M, THR173N, THR178M, THR180M, THR186N, THR192N, THR43M, THR56N, THR62N, THR97M, TRP103N, TRP157N, TRP163M, TRP199N, TRP35M, TRP36N, TRP47N, TYR122N, TYR173M, TYR185N, TYR186M, TYR49M, TYR50N, TYR58N, TYR59N, TYR86M, TYR87M, TYR91M, TYR91N, TYR96M, TYR97N, TYR98N, VAL115M, VAL121N, VAL127N, VAL132M, VAL133M, VAL138N, VAL144N, VAL159M, VAL171N, VAL177N, VAL191N, VAL206M, VAL37N, VAL48N
• N-O: ASN73N, ASP72N, GLN124O, GLU123O, LYS75N, PRO74N, SER127O, SER30N, THR126O
• N-P: ALA101N, ALA118P, ALA214P, ALA23N, ALA24N, ARG18P, ASN162N, ASN209N, ASN73N, ASN76N, ASP220N, ASP220P, ASP72N, ASP72P, CYS22N, GLN13P, GLN203N, GLN81P, GLY100N, GLY146P, GLY15P, GLY16P, GLY26N, HIS212P, LEU184P, LEU4N, LYS115P, LYS145P, LYS19N, LYS19P, LYS218N, LYS218P, LYS221P, LYS3N, LYS75N, LYS75P, MET82P, PHE148P, PHE27N, PHE29N, PHE79N, PHE79P, PRO119P, PRO14P, PRO213N, PRO213P, PRO74N, PRO74P, SER120P, SER163N, SER165N, SER17P, SER204N, SER215N, SER215P, SER216N, SER216P, SER21N, SER25N, SER30N, SER7N, SER82P, THR116P, THR117P, THR206N, THR217N, THR217P, THR28N, THR77N, THR82P, TRP103N, TYR102N, TYR122P, TYR147P, VAL121P, VAL12P, VAL219N, VAL219P, VAL5N
• O-P: ALA125P, ALA130O, ALA176P, ALA49P, ALA60P, ALA93P, ARG100P, ARG211O, ARG226P, ARG38P, ARG46O, ARG94P, ASN137O, ASN138O, ASN157O, ASN161O, ASN210O, ASN212O, ASP130P, ASP165O, ASP167O, ASP170O, ASP41O, ASP55O, ASP61P, ASP85O, ASP96P, CYS128P, CYS134O, CYS142P, CYS194O, CYS214O, CYS88O, CYS92P, GLN105P, GLN124O, GLN179P, GLN1O, GLN37O, GLN38O, GLN39P, GLN90O, GLU123O, GLU213O, GLU42P, GLU46P, GLU6P, GLY100O, GLY100P, GLY101O, GLY104P, GLY106P, GLY128O, GLY129O, GLY129P, GLY135P, GLY141P, GLY158O, GLY169P, GLY227P, GLY42O, GLY44P, GLY57O, GLY95P, GLY99O, GLY99P, HIS172P, HIS35P, ILE117O, ILE223P, ILE44O, ILE48O, ILE51P, ILE57P, LEU124P, LEU125O, LEU136O, LEU140P, LEU143P, LEU160O, LEU178P, LEU179O, LEU181O, LEU184P, LEU187P, LEU36O, LEU45P, LEU47O, LEU4P, LEU89O, LYS103O, LYS142O, LYS145P, LYS169O, LYS207O, LYS221P, LYS222P, LYS39O, LYS43P, LYS45O, LYS64P, MET175O, MET34P, MET89P, PHE118O, PHE135O, PHE139O, PHE174P, PHE209O, PHE98O, PRO113O, PRO119O, PRO120O, PRO123P, PRO126P, PRO175P, PRO40O, PRO95O, SER100P, SER116O, SER120P, SER121O, SER122O, SER127O, SER131O, SER137P, SER162O, SER167P, SER168P, SER174O, SER176O, SER177O, SER180P, SER188P, SER189P, SER190P, SER208O, SER34O, SER56O, SER93O, SER94O, THR114O, THR126O, THR133P, THR134P, THR139P, THR164O, THR172O, THR173P, THR178O, THR180O, THR186P, THR192P, THR43O, THR56P, THR62P, THR97O, TRP157P, TRP163O, TRP199P, TRP35O, TRP36P, TRP47P, TYR122P, TYR173O, TYR185P, TYR186O, TYR49O, TYR50P, TYR58P, TYR59P, TYR86O, TYR87O, TYR91O, TYR91P, TYR96O, TYR97P, TYR98P, VAL115O, VAL121P, VAL127P, VAL132O, VAL133O, VAL138P, VAL144P, VAL159O, VAL171P, VAL177P, VAL191P, VAL206O, VAL37P, VAL48P, VAL58O