2GF0

the crystal structure of the human diras1 gtpase in the inactive gdp bound state

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 53
  • Norm. En. per Res.: -4.0831
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-37.9007	-20.3101	-141.054	-199.2648	60	3	4	5913	4	13	21
A-C	-34.2254	-42.2352	-148.015	-224.4756	60	3	0	5675	1	15	8
B-C	-9.352	0.7915	-49.6206	-58.1812	32	3	0	2357	0	11	12
B-D	-33.4968	-42.2701	-140.64	-216.4069	53	7	0	5436	2	13	9
C-D	-32.9435	21.4339	-159.946	-171.4556	58	6	2	5718	0	13	19

Interface residues

• A-B: ALA135A, ALA137A, ALA139A, ALA70B, ARG133A, ARG33B, ASP131A, ASP34B, ASP42B, ASP61B, GLN106A, GLN136A, GLN140A, GLN67B, GLN92A, GLU129A, GLU134A, GLU141A, GLU41B, GLU95A, GLU96A, GLY109A, GLY16B, GLY17B, GLY98A, HIS66B, ILE100A, ILE104A, ILE37B, ILE40B, LEU103A, LEU118A, LEU84A, LEU94A, LEU97A, LYS102A, LYS143A, LYS91A, MET71B, PHE32B, PHE68B, PHE86A, PRO38B, PRO69B, PRO99A, SER110A, SER65B, SER93A, THR35B, THR39B, THR43B, THR60B, THR63B, TRP142A, TYR101A, TYR36B, VAL105A, VAL111A, VAL130A, VAL138A
• A-C: ALA151C, ALA70A, ARG128C, ARG26C, ARG33C, ARG73A, ASN154C, ASN156C, ASP124C, ASP34C, CYS123C, GLN106A, GLN127C, GLN67A, GLN72A, GLN92A, GLU125C, GLU148C, GLU159C, GLU95A, GLU96A, GLY120C, GLY30C, GLY64A, GLY98A, HIS66A, ILE100A, ILE104A, ILE107A, ILE76A, LEU103A, LEU74A, LEU97A, LYS102A, LYS122C, LYS152C, LYS158C, LYS78A, MET147C, MET153C, MET71A, PHE13A, PHE146C, PHE32C, PHE68A, PRO69A, PRO99A, SER150C, SER65A, SER75A, SER77A, THR126C, THR132C, THR149C, THR31C, THR35C, THR63A, TYR101A, TYR155C, VAL88C
• B-C: ARG26B, ARG26C, ARG33B, ARG33C, ASN154C, ASP34B, ASP34C, GLN46C, GLY30B, GLY30C, ILE37B, ILE37C, LEU25B, LEU25C, LYS29B, LYS29C, PHE27C, PHE32B, PHE32C, PRO38C, THR31B, THR31C, THR35B, THR35C, THR39C, TYR36B, TYR44B, TYR44C, VAL28B, VAL28C, VAL47B, VAL47C
• B-D: ALA151B, ALA70D, ARG128B, ARG26B, ARG73D, ASN154B, ASN156B, ASP124B, CYS123B, GLN106D, GLN127B, GLN67D, GLN72D, GLN92D, GLU125B, GLU148B, GLU159B, GLU95D, GLU96D, GLY120B, GLY98D, HIS66D, ILE100D, ILE104D, ILE107D, ILE76D, LEU103D, LEU74D, LEU97D, LYS102D, LYS122B, LYS152B, LYS158B, LYS78D, MET147B, MET153B, MET71D, PHE32B, PHE68D, PRO69D, PRO99D, SER150B, SER65D, SER75D, SER77D, THR126B, THR132B, THR149B, THR31B, TYR101D, TYR155B, VAL157B, VAL88B
• C-D: ALA135D, ALA137D, ALA139D, ALA70C, ARG133D, ASP131D, ASP42C, ASP61C, GLN106D, GLN136D, GLN140D, GLN67C, GLN92D, GLU134D, GLU141D, GLU41C, GLU95D, GLU96D, GLY16C, GLY17C, GLY64C, GLY98D, HIS66C, ILE100D, ILE37C, ILE40C, LEU103D, LEU118D, LEU74C, LEU84D, LEU94D, LEU97D, LYS102D, LYS143D, LYS20C, LYS91D, MET71C, PHE68C, PHE86D, PRO38C, PRO69C, PRO99D, SER21C, SER65C, SER93D, THR132D, THR35C, THR39C, THR43C, THR62C, THR63C, TRP142D, TYR101D, TYR36C, VAL105D, VAL111D, VAL130D, VAL138D