2GCG

ternary crystal structure of human glyoxylate reductase/hydroxypyruvate reductase

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 249
  • Norm. En. per Res.: -4.6976
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-108.6011	-63.3791	-947.729	-1119.7092	244	43	23	38263	5	50	64
A-C	0.0	26.7096	-13.4082	13.3014	25	0	0	690	0	3	4
C-D	-138.8356	-75.8377	-955.033	-1169.7064	249	48	24	38410	6	51	66

Interface residues

• A-B: ALA112A, ALA112B, ALA115A, ALA115B, ALA129A, ALA129B, ALA167A, ALA167B, ALA169A, ALA169B, ALA17A, ALA17B, ALA297A, ALA297B, ARG124A, ARG124B, ARG125A, ARG125B, ARG13A, ARG13B, ARG14A, ARG14B, ARG170A, ARG170B, ARG171A, ARG171B, ARG20A, ARG20B, ARG245A, ARG245B, ARG300A, ARG300B, ARG302A, ARG302B, ASN135A, ASN135B, ASN279A, ASN279B, ASN303A, ASN303B, ASP109A, ASP109B, ASP210A, ASP269A, ASP269B, ASP37A, ASP37B, ASP61A, ASP61B, CYS123A, CYS123B, CYS147A, CYS147B, CYS288A, CYS288B, CYS57A, CYS57B, GLN153A, GLN153B, GLN178B, GLU113A, GLU113B, GLU128A, GLU128B, GLU131A, GLU131B, GLU132A, GLU132B, GLU18A, GLU18B, GLU194A, GLU194B, GLU274A, GLU274B, GLU38A, GLU38B, GLY136A, GLY136B, GLY137A, GLY137B, GLY148A, GLY148B, GLY150A, GLY150B, GLY176A, GLY176B, GLY295A, GLY295B, HIS280A, HIS280B, HIS293A, HIS293B, HIS299A, HIS299B, ILE130A, ILE130B, ILE15A, ILE15B, ILE168A, ILE168B, ILE290A, ILE290B, ILE294A, ILE294B, ILE40A, ILE40B, LEU107A, LEU107B, LEU114A, LEU114B, LEU118A, LEU118B, LEU119A, LEU119B, LEU120A, LEU120B, LEU126A, LEU126B, LEU144A, LEU144B, LEU146A, LEU146B, LEU151A, LEU151B, LEU172A, LEU172B, LEU268A, LEU268B, LEU276A, LEU276B, LEU282A, LEU282B, LEU283A, LEU283B, LEU285A, LEU285B, LEU291A, LEU291B, LEU58A, LEU58B, LEU59A, LEU59B, LYS134A, LYS134B, LYS142A, LYS142B, LYS173A, LYS173B, LYS235A, LYS286A, LYS286B, MET305A, MET305B, MET81A, MET81B, PHE175A, PHE175B, PHE195A, PHE195B, PHE211A, PHE211B, PRO127A, PRO127B, PRO143A, PRO143B, PRO16A, PRO16B, PRO174A, PRO174B, PRO273A, PRO273B, PRO275A, PRO275B, PRO277A, PRO277B, PRO292A, PRO292B, PRO39A, PRO39B, SER117A, SER117B, SER140A, SER140B, SER154A, SER154B, SER272A, SER272B, SER296A, SER296B, SER306A, SER306B, SER36A, SER36B, SER60A, SER60B, SER82A, SER82B, THR103B, THR110A, THR110B, THR111A, THR111B, THR121A, THR121B, THR122A, THR122B, THR12A, THR139A, THR139B, THR152A, THR152B, THR155A, THR237A, THR271A, THR271B, THR278A, THR278B, THR284A, THR284B, THR298A, THR298B, THR301A, THR301B, TRP138A, TRP138B, TRP141A, TRP141B, TRP145A, TRP145B, TYR149A, TYR149B, VAL116A, VAL116B, VAL11A, VAL133A, VAL133B, VAL177A, VAL177B, VAL270A, VAL270B, VAL289A, VAL289B, VAL83A, VAL83B
• A-C: ALA207A, ALA207C, ARG179A, ARG179C, GLN208A, GLN208C, GLU198A, GLU198C, GLU204A, GLU204C, LEU205A, LEU205C, LYS233A, LYS233C, PHE199A, PHE199C, PRO187A, PRO187C, PRO203A, PRO203C, SER201A, SER201C, THR202A, VAL200A, VAL200C
• C-D: ALA112C, ALA112D, ALA115C, ALA115D, ALA129C, ALA129D, ALA167C, ALA167D, ALA169C, ALA169D, ALA17C, ALA17D, ALA264C, ALA297C, ALA297D, ARG124C, ARG124D, ARG125C, ARG125D, ARG13C, ARG13D, ARG14C, ARG14D, ARG170C, ARG170D, ARG171C, ARG171D, ARG20C, ARG20D, ARG245C, ARG245D, ARG300C, ARG300D, ARG302C, ARG302D, ASN135C, ASN135D, ASN279C, ASN279D, ASN303C, ASN303D, ASP109C, ASP109D, ASP210C, ASP210D, ASP269C, ASP269D, ASP37C, ASP37D, ASP61C, ASP61D, CYS123C, CYS123D, CYS147C, CYS147D, CYS288C, CYS288D, CYS57C, CYS57D, GLN153C, GLN153D, GLN178C, GLN178D, GLU113C, GLU113D, GLU128C, GLU128D, GLU131C, GLU131D, GLU132C, GLU132D, GLU18C, GLU18D, GLU194C, GLU194D, GLU274C, GLU274D, GLU38C, GLU38D, GLY136C, GLY136D, GLY137C, GLY137D, GLY148C, GLY148D, GLY150C, GLY150D, GLY176C, GLY176D, GLY19D, GLY295C, GLY295D, HIS280C, HIS280D, HIS293C, HIS293D, HIS299C, HIS299D, ILE130C, ILE130D, ILE15C, ILE15D, ILE168C, ILE168D, ILE290C, ILE290D, ILE294C, ILE294D, ILE40C, ILE40D, LEU107C, LEU107D, LEU114C, LEU114D, LEU118C, LEU118D, LEU119C, LEU119D, LEU120C, LEU120D, LEU126C, LEU126D, LEU144C, LEU144D, LEU146C, LEU146D, LEU151C, LEU151D, LEU172C, LEU172D, LEU268C, LEU268D, LEU276C, LEU276D, LEU282C, LEU282D, LEU283C, LEU283D, LEU285C, LEU285D, LEU291C, LEU291D, LEU58C, LEU58D, LEU59C, LEU59D, LYS134C, LYS134D, LYS142C, LYS142D, LYS173C, LYS173D, LYS286C, LYS286D, MET305C, MET305D, MET81C, MET81D, PHE175C, PHE175D, PHE195C, PHE195D, PHE211C, PHE211D, PRO127C, PRO127D, PRO143C, PRO143D, PRO16C, PRO16D, PRO174C, PRO174D, PRO273C, PRO273D, PRO275C, PRO275D, PRO277C, PRO277D, PRO292C, PRO292D, PRO39C, PRO39D, SER117C, SER117D, SER140C, SER140D, SER154C, SER154D, SER272C, SER272D, SER296C, SER296D, SER306C, SER306D, SER36C, SER36D, SER60C, SER60D, SER82C, SER82D, THR103D, THR110C, THR110D, THR111C, THR111D, THR121C, THR121D, THR122C, THR122D, THR12D, THR139C, THR139D, THR152C, THR152D, THR155C, THR237C, THR271C, THR271D, THR278C, THR278D, THR284C, THR284D, THR298C, THR298D, THR301C, THR301D, TRP138C, TRP138D, TRP141C, TRP141D, TRP145C, TRP145D, TYR149C, TYR149D, VAL106C, VAL106D, VAL116C, VAL116D, VAL11C, VAL133C, VAL133D, VAL177C, VAL177D, VAL270C, VAL270D, VAL289C, VAL289D, VAL83C, VAL83D