2G99

structural basis for the specific recognition of methylated histone h3 lysine 4 by the wd-40 protein wdr5

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 55
  • Norm. En. per Res.: -2.9513
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-6.7884	-19.3874	-91.0464	-117.2222	61	4	0	3900	2	23	17
A-D	-22.8769	-18.3311	-117.946	-159.154	55	7	1	4529	1	8	10
B-C	-15.0826	-17.9359	-129.302	-162.3204	55	8	3	4769	0	8	9

Interface residues

• A-B: ALA74A, ARG181B, ASN100A, ASN100B, ASN138B, ASN142B, ASN180B, ASN225B, ASN314A, ASN56A, ASN56B, ASP182B, ASP333A, ASP76A, ASP98B, GLN140B, GLU313A, GLU313B, GLU58A, GLU80A, GLY183B, GLY226B, GLY57A, GLY57B, GLY73A, GLY77A, HIS310A, HIS310B, ILE315A, LEU101B, LEU143B, LEU37A, LYS159B, LYS227B, LYS331A, LYS38A, LYS78A, PHE39A, PHE79A, PRO139B, PRO224B, PRO311A, PRO311B, PRO55A, PRO55B, SER117A, SER141B, SER184B, SER332A, SER54A, SER54B, SER96B, SER97B, SER99A, SER99B, THR269B, THR312A, THR312B, TRP59A, TYR75A, VAL268B
• A-D: ALA105A, ALA176A, ALA1D, ALA264A, ALA319A, ALA320A, ALA47A, ALA65A, ARG2D, ASP107A, ASP108A, ASP66A, ASP92A, CYS134A, CYS135A, CYS261A, GLN5D, GLU322A, GLY147A, GLY89A, ILE262A, ILE305A, ILE90A, LEU321A, LEU88A, LYS259A, LYS325A, LYS46A, LYS52A, PHE133A, PHE149A, PHE219A, PHE263A, SER106A, SER175A, SER189A, SER218A, SER306A, SER49A, SER50A, SER63A, SER64A, SER91A, THR3D, TYR131A, TYR191A, TYR260A, VAL132A, VAL174A, VAL177A, VAL220A, VAL303A, VAL48A, VAL51A, VAL93A
• B-C: ALA105B, ALA176B, ALA1C, ALA264B, ALA320B, ALA47B, ALA65B, ARG2C, ASP107B, ASP108B, ASP66B, ASP92B, CYS134B, CYS135B, CYS261B, GLN5C, GLU258B, GLU279B, GLU322B, GLY147B, GLY89B, ILE262B, ILE305B, ILE90B, LEU234B, LEU321B, LEU88B, LYS259B, LYS46B, LYS52B, PHE133B, PHE149B, PHE219B, PHE263B, SER106B, SER175B, SER218B, SER306B, SER49B, SER50B, SER63B, SER64B, SER91B, THR3C, TYR131B, TYR191B, TYR260B, VAL132B, VAL174B, VAL177B, VAL220B, VAL303B, VAL48B, VAL51B, VAL93B