2G50

the location of the allosteric amino acid binding site of muscle pyruvate kinase.

• Total interactions analyzed: 28
• Total true interactions: 17
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 140
  • Norm. En. per Res.: -3.8318
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-89.1383	-45.1154	340.549	206.2953	160	45	8	15400	3	40	36
A-C	-131.789	-56.2365	-725.588	-913.6135	263	29	20	32427	5	151	129
A-D	0.0	29.8451	-5.9051	23.9399	13	0	0	192	0	8	7
A-F	0.0	2.0536	-0.8258	1.2279	14	0	0	253	0	8	8
B-C	0.0	28.7328	-5.2456	23.4872	10	0	0	166	0	6	6
B-D	-133.4243	-76.8994	-725.507	-935.8307	268	25	21	32117	7	150	130
C-D	-115.9283	-20.7963	-341.556	-478.2805	137	15	8	13954	2	40	36
C-E	0.0	0.0	-38.3233	-38.3233	35	0	2	1736	0	8	12
C-F	-18.702	2.7674	-95.8836	-111.8182	73	3	3	4435	2	34	37
D-F	0.0	0.0	432.383	432.383	28	48	0	531	0	0	0
D-H	0.0	0.0	645.821	645.821	22	37	0	583	0	0	0
E-F	-111.9632	-55.8803	-368.614	-536.4574	140	16	8	14970	6	41	36
E-G	-150.263	-121.8687	-734.979	-1007.1107	263	23	20	32373	10	155	131
E-H	0.0	49.8453	-7.0336	42.8117	12	0	0	243	0	8	7
F-G	0.0	38.8681	-5.6492	33.2189	12	0	0	176	0	6	6
F-H	-147.5901	-207.2949	-53.2346	-408.1196	272	56	20	34055	17	152	129
G-H	-108.4885	-45.7867	-372.778	-527.0532	141	20	8	14878	4	40	36

Interface residues

• A-B: ALA20A, ALA20B, ALA22A, ALA22B, ALA398A, ALA398B, ALA400A, ALA400B, ALA410A, ALA410B, ALA412A, ALA412B, ALA418A, ALA418B, ALA424A, ALA424B, ALA482A, ALA482B, ALA98A, ARG391A, ARG391B, ARG399A, ARG399B, ARG442A, ARG442B, ARG446A, ARG446B, ARG515A, ARG515B, ARG525A, ARG525B, ASN494A, ASN522A, ASN522B, ASP100A, ASP23A, ASP23B, ASP406A, ASP406B, ASP475A, ASP486A, ASP486B, ASP506A, ASP506B, CYS422A, CYS422B, CYS473A, GLN13A, GLN13B, GLN403A, GLN403B, GLN439A, GLN439B, GLU27A, GLU395A, GLU395B, GLU396A, GLU396B, GLU409A, GLU409B, GLU417A, GLU417B, GLY414A, GLY414B, GLY505A, GLY505B, GLY513A, GLY513B, ILE102A, ILE509A, ILE509B, LEU103A, LEU17A, LEU17B, LEU397A, LEU397B, LEU407A, LEU407B, LEU423A, LEU423B, LEU491A, LEU511A, LEU511B, LYS392A, LYS392B, LYS421A, LYS421B, LYS474A, MET21A, MET21B, MET408A, MET408B, MET411A, MET411B, MET413A, MET413B, MET524A, MET524B, PHE2B, PHE389A, PHE389B, PHE394A, PHE394B, PHE520A, PHE520B, PRO101A, PRO528A, PRO528B, PRO530A, SER401A, SER401B, SER402A, SER402B, SER404A, SER404B, SER415A, SER415B, SER419A, SER419B, SER518A, SER99A, THR24A, THR24B, THR405A, THR405B, THR512A, THR512B, THR521A, THR521B, THR523A, THR523B, TRP481A, TRP481B, TRP514A, TRP514B, TYR104A, TYR420A, TYR420B, TYR443A, TYR443B, TYR8B, VAL416A, VAL416B, VAL471A, VAL472A, VAL485A, VAL485B, VAL489A, VAL489B, VAL495A, VAL507A, VAL507B, VAL508A, VAL508B, VAL510A, VAL510B, VAL526A, VAL526B, VAL527A, VAL527B
• A-C: ALA19A, ALA19C, ALA22A, ALA292A, ALA292C, ALA302A, ALA302C, ALA308A, ALA308C, ALA319A, ALA319C, ALA326A, ALA326C, ALA342A, ALA342C, ALA348A, ALA348C, ALA350A, ALA350C, ALA355A, ALA37A, ALA37C, ALA381A, ALA381C, ALA384A, ALA384C, ALA386A, ALA386C, ALA387A, ALA387C, ALA398A, ALA398C, ALA400A, ALA400C, ARG277A, ARG277C, ARG293A, ARG293C, ARG315A, ARG315C, ARG318A, ARG318C, ARG31A, ARG31C, ARG338A, ARG338C, ARG341A, ARG341C, ARG375A, ARG375C, ARG382A, ARG382C, ARG399A, ARG399C, ARG444C, ASN198A, ASN198C, ASN209A, ASN209C, ASN272A, ASN272C, ASN317A, ASN317C, ASN349A, ASN349C, ASP176A, ASP176C, ASP177A, ASP177C, ASP23A, ASP23C, ASP280A, ASP280C, ASP295A, ASP295C, ASP33A, ASP33C, ASP346A, ASP346C, ASP353A, ASP353C, ASP35A, ASP35C, CYS30A, CYS30C, CYS316A, CYS316C, CYS325A, CYS325C, GLN16A, GLN16C, GLN309A, GLN309C, GLN328A, GLN328C, GLN377A, GLN377C, GLU274A, GLU274C, GLU27A, GLU27C, GLU299A, GLU299C, GLU303A, GLU303C, GLU331A, GLU331C, GLU343A, GLU343C, GLU363A, GLU363C, GLU372A, GLU372C, GLU383A, GLU383C, GLU385A, GLU385C, GLU395A, GLU395C, GLU396A, GLU396C, GLY178A, GLY178C, GLY199A, GLY199C, GLY200A, GLY200C, GLY275A, GLY275C, GLY294A, GLY294C, GLY297A, GLY297C, GLY314A, GLY314C, GLY320C, GLY344A, GLY344C, GLY354A, GLY354C, HIS18A, HIS18C, HIS273A, HIS273C, HIS28A, HIS28C, HIS378A, HIS378C, ILE12A, ILE12C, ILE180A, ILE180C, ILE270A, ILE270C, ILE298A, ILE298C, ILE300A, ILE300C, ILE312A, ILE312C, ILE313A, ILE313C, ILE334A, ILE334C, ILE34A, ILE34C, ILE380A, ILE380C, LEU179A, LEU179C, LEU26A, LEU26C, LEU296A, LEU296C, LEU307A, LEU307C, LEU32A, LEU32C, LEU330A, LEU330C, LEU352A, LEU352C, LEU379A, LEU379C, LEU393A, LEU393C, LEU397A, LEU397C, LYS135A, LYS29A, LYS29C, LYS304A, LYS304C, LYS310A, LYS310C, LYS335A, LYS335C, LYS336A, LYS336C, LYS366A, LYS366C, LYS392A, LYS392C, MET311A, MET311C, MET329A, MET329C, MET333A, MET333C, MET376A, MET376C, MET388A, MET388C, PHE201A, PHE25A, PHE25C, PHE279A, PHE279C, PHE306A, PHE306C, PHE389A, PHE389C, PHE394A, PHE394C, PRO301A, PRO301C, PRO337A, PRO337C, PRO339A, PRO339C, PRO38A, PRO38C, SER181A, SER181C, SER332A, SER332C, SER345A, SER345C, SER36A, SER36C, SER401A, SER401C, THR24A, THR24C, THR327A, THR327C, THR340A, THR340C, TYR174A, TYR174C, TYR369A, TYR369C, VAL276A, VAL276C, VAL291A, VAL291C, VAL305A, VAL305C, VAL323A, VAL347A, VAL347C, VAL351A, VAL351C
• A-D: ALA22D, ARG31A, ARG31D, ARG391A, ARG391D, ARG399A, ARG399D, ASP23A, ASP23D, GLU27A, GLU27D, THR24A, THR24D
• A-F: ALA137A, ARG515F, ASN154A, GLN186A, GLU195A, GLU479F, GLY136A, GLY517F, LYS134A, LYS135A, PRO476F, PRO516F, THR138A, VAL477F
• B-C: ARG391B, ARG391C, ARG399B, ARG399C, ASP23B, ASP23C, LYS392B, LYS392C, THR24B, THR24C
• B-D: ALA19B, ALA19D, ALA22B, ALA22D, ALA292B, ALA292D, ALA302B, ALA302D, ALA308B, ALA308D, ALA319B, ALA319D, ALA326B, ALA326D, ALA342B, ALA342D, ALA348B, ALA348D, ALA350B, ALA350D, ALA37B, ALA37D, ALA381B, ALA381D, ALA384B, ALA384D, ALA386B, ALA386D, ALA387B, ALA387D, ALA398B, ALA398D, ALA400B, ALA400D, ARG277B, ARG277D, ARG293B, ARG293D, ARG315B, ARG315D, ARG318B, ARG318D, ARG31B, ARG31D, ARG338B, ARG338D, ARG341B, ARG341D, ARG375B, ARG375D, ARG382B, ARG382D, ARG391B, ARG391D, ARG399B, ARG399D, ARG444B, ASN198B, ASN198D, ASN209B, ASN209D, ASN272B, ASN272D, ASN317B, ASN317D, ASN349B, ASN349D, ASP176B, ASP176D, ASP177B, ASP177D, ASP23B, ASP23D, ASP280B, ASP280D, ASP295B, ASP295D, ASP33B, ASP33D, ASP346B, ASP346D, ASP353B, ASP353D, ASP35B, ASP35D, CYS30B, CYS30D, CYS316B, CYS316D, CYS325B, CYS325D, GLN16B, GLN16D, GLN309B, GLN309D, GLN328B, GLN328D, GLN377B, GLN377D, GLU274B, GLU274D, GLU27B, GLU27D, GLU299B, GLU299D, GLU303B, GLU303D, GLU331B, GLU331D, GLU343B, GLU343D, GLU363B, GLU363D, GLU372B, GLU372D, GLU383B, GLU383D, GLU385B, GLU385D, GLU395B, GLU395D, GLU396B, GLU396D, GLY178B, GLY178D, GLY199B, GLY199D, GLY200B, GLY200D, GLY275B, GLY275D, GLY294B, GLY294D, GLY297B, GLY297D, GLY314B, GLY314D, GLY320B, GLY320D, GLY344B, GLY344D, GLY354B, GLY354D, HIS18B, HIS18D, HIS273B, HIS273D, HIS28B, HIS28D, HIS378B, HIS378D, ILE12B, ILE12D, ILE180B, ILE180D, ILE270B, ILE270D, ILE298B, ILE298D, ILE300B, ILE300D, ILE312B, ILE312D, ILE313B, ILE313D, ILE334B, ILE334D, ILE34B, ILE34D, ILE380B, ILE380D, LEU179B, LEU179D, LEU26B, LEU26D, LEU283B, LEU296B, LEU296D, LEU307B, LEU307D, LEU32B, LEU32D, LEU330B, LEU330D, LEU352B, LEU352D, LEU379B, LEU379D, LEU393B, LEU393D, LEU397B, LEU397D, LYS135B, LYS135D, LYS29B, LYS29D, LYS304B, LYS304D, LYS310B, LYS310D, LYS335B, LYS335D, LYS336B, LYS336D, LYS366B, LYS366D, LYS392B, LYS392D, MET311B, MET311D, MET329B, MET329D, MET333B, MET333D, MET376B, MET376D, MET388B, MET388D, PHE201D, PHE25B, PHE25D, PHE279B, PHE279D, PHE2B, PHE306B, PHE306D, PHE389B, PHE389D, PHE394B, PHE394D, PRO301B, PRO301D, PRO337B, PRO337D, PRO339B, PRO339D, PRO38B, PRO38D, SER181B, SER181D, SER332B, SER332D, SER345B, SER345D, SER36B, SER36D, SER401B, SER401D, THR24B, THR24D, THR327B, THR327D, THR340B, THR340D, TYR174B, TYR174D, TYR369B, TYR369D, VAL276B, VAL276D, VAL291B, VAL291D, VAL305B, VAL305D, VAL347B, VAL347D, VAL351B, VAL351D
• C-D: ALA20D, ALA22C, ALA22D, ALA398C, ALA398D, ALA400C, ALA400D, ALA410C, ALA410D, ALA412C, ALA412D, ALA418C, ALA418D, ALA424C, ALA424D, ALA482C, ALA482D, ARG391C, ARG391D, ARG399C, ARG399D, ARG442C, ARG442D, ARG446D, ARG515C, ARG515D, ARG525C, ARG525D, ASN522C, ASN522D, ASP23C, ASP23D, ASP406C, ASP406D, ASP486C, ASP486D, ASP506C, ASP506D, CYS422C, CYS422D, GLN13C, GLN403C, GLN403D, GLN439C, GLN439D, GLU395C, GLU395D, GLU396C, GLU396D, GLU409C, GLU409D, GLU417C, GLU417D, GLY414C, GLY414D, GLY505C, GLY505D, GLY513C, GLY513D, ILE509C, ILE509D, LEU17C, LEU17D, LEU397C, LEU397D, LEU407C, LEU407D, LEU423C, LEU423D, LEU511C, LEU511D, LYS392C, LYS392D, LYS421C, LYS421D, MET21C, MET21D, MET408C, MET408D, MET411C, MET411D, MET413C, MET413D, MET524C, MET524D, PHE394C, PHE394D, PHE520C, PHE520D, PRO528C, PRO528D, PRO530D, SER401C, SER401D, SER402C, SER402D, SER404C, SER404D, SER415C, SER415D, SER419C, SER419D, SER518D, THR24C, THR24D, THR405C, THR405D, THR512C, THR512D, THR521C, THR521D, THR523C, THR523D, TRP481C, TRP481D, TRP514C, TRP514D, TYR420C, TYR420D, TYR443C, TYR443D, VAL416C, VAL416D, VAL485C, VAL485D, VAL489C, VAL489D, VAL507C, VAL507D, VAL508C, VAL508D, VAL510C, VAL510D, VAL526C, VAL526D, VAL527C, VAL527D
• C-E: ALA10E, ALA37E, ALA53C, ALA84C, ARG55C, ARG91C, ASN89C, ASP235C, ASP35E, ASP368C, GLN13E, GLN234C, GLU233C, GLU81C, GLU85C, GLY505E, HIS18E, HIS80C, HIS83C, ILE12E, ILE87C, LEU17E, LEU423E, LYS366C, LYS503E, LYS504E, LYS88C, MET21E, PHE11E, PHE230C, PRO52C, SER56C, THR14E, THR86C, TYR82C
• C-F: ALA219F, ALA247F, ALA248F, ALA285F, ALA498C, ALA98C, ARG254F, ARG278F, ARG499C, ASN490C, ASN494C, ASP100C, ASP249F, ASP280F, ASP406F, ASP475C, ASP506C, CYS473C, GLN403F, GLU222F, GLU252F, GLU281F, GLU284F, GLU409F, GLU58C, GLU95C, GLY496C, GLY500C, HIS251F, ILE102C, ILE225F, ILE256F, ILE282F, LEU103C, LEU283F, LEU407F, LEU487C, LEU491C, LYS229F, LYS246F, LYS255F, LYS321F, LYS474C, LYS497C, LYS503C, LYS504C, LYS61C, LYS88C, MET408F, MET493C, PHE279F, PHE501C, PHE502C, PHE520F, PHE97C, PRO101C, PRO218F, PRO530C, SER221F, SER286F, SER404F, SER56C, SER96C, SER99C, THR405F, THR40C, THR92C, TYR104C, VAL220F, VAL250F, VAL495C, VAL529C, VAL57C
• D-F: ALA84D, ALA93D, ARG55D, ARG91D, ASN89D, GLN234D, GLU85D, GLU95D, HIS83D, ILE50D, ILE64D, ILE87D, LEU60D, LYS88D, MET73D, PHE2F, SER96D, THR79D, THR86D, THR92D, THR94D, TYR104D, TYR82D, TYR8F, VAL107D, VAL109D, VAL57D, VAL90D
• D-H: ALA108D, ALA71D, ALA93D, ARG460D, ARG91D, ASN89D, GLU95D, ILE50D, ILE64D, ILE87D, LEU60D, LYS88D, MET68D, MET73D, PHE2H, SER96D, THR86D, THR92D, THR94D, VAL107D, VAL109D, VAL90D
• E-F: ALA20E, ALA22E, ALA22F, ALA398E, ALA398F, ALA400E, ALA400F, ALA410E, ALA410F, ALA412E, ALA412F, ALA418E, ALA418F, ALA424E, ALA424F, ALA482E, ALA482F, ARG31E, ARG31F, ARG391E, ARG391F, ARG399E, ARG399F, ARG442E, ARG442F, ARG515E, ARG515F, ARG525E, ARG525F, ASN522E, ASN522F, ASP23E, ASP23F, ASP406E, ASP406F, ASP486E, ASP486F, ASP506E, ASP506F, CYS422E, CYS422F, GLN13E, GLN403E, GLN403F, GLN439E, GLN439F, GLU27E, GLU27F, GLU395E, GLU395F, GLU396E, GLU396F, GLU409E, GLU409F, GLU417E, GLU417F, GLU483F, GLY414E, GLY414F, GLY505E, GLY505F, GLY513E, GLY513F, ILE509E, ILE509F, LEU17E, LEU17F, LEU397E, LEU397F, LEU407E, LEU407F, LEU423E, LEU423F, LEU511E, LEU511F, LYS392E, LYS392F, LYS421E, LYS421F, MET21E, MET21F, MET408E, MET408F, MET411E, MET411F, MET413E, MET413F, MET524E, MET524F, PHE394E, PHE394F, PHE520E, PHE520F, PRO528E, PRO528F, PRO530E, SER401E, SER401F, SER402E, SER402F, SER404E, SER404F, SER415E, SER415F, SER419E, SER419F, THR24E, THR24F, THR405E, THR405F, THR512E, THR512F, THR521E, THR521F, THR523E, THR523F, TRP481E, TRP481F, TRP514E, TRP514F, TYR420E, TYR420F, TYR443E, TYR443F, VAL416E, VAL416F, VAL485E, VAL485F, VAL489E, VAL489F, VAL507E, VAL507F, VAL508E, VAL508F, VAL510E, VAL510F, VAL526E, VAL526F, VAL527E, VAL527F
• E-G: ALA19E, ALA19G, ALA22E, ALA22G, ALA292E, ALA292G, ALA302E, ALA302G, ALA308E, ALA308G, ALA319E, ALA319G, ALA326E, ALA326G, ALA342E, ALA342G, ALA348E, ALA348G, ALA350E, ALA350G, ALA37E, ALA37G, ALA381E, ALA381G, ALA384E, ALA384G, ALA386E, ALA386G, ALA387E, ALA387G, ALA398E, ALA398G, ALA400E, ALA400G, ARG277E, ARG277G, ARG293E, ARG293G, ARG315E, ARG315G, ARG318E, ARG318G, ARG31E, ARG31G, ARG338E, ARG338G, ARG341E, ARG341G, ARG375E, ARG375G, ARG382E, ARG382G, ARG391E, ARG391G, ARG399E, ARG399G, ARG444G, ASN198E, ASN198G, ASN209E, ASN209G, ASN272E, ASN272G, ASN317E, ASN317G, ASN349E, ASN349G, ASP176E, ASP176G, ASP177E, ASP177G, ASP23E, ASP23G, ASP280E, ASP280G, ASP295E, ASP295G, ASP33E, ASP33G, ASP346E, ASP346G, ASP353E, ASP353G, ASP35E, ASP35G, CYS30E, CYS30G, CYS316E, CYS316G, CYS325E, CYS325G, GLN16E, GLN16G, GLN309E, GLN309G, GLN328E, GLN328G, GLN377E, GLN377G, GLU274E, GLU274G, GLU27E, GLU27G, GLU299E, GLU299G, GLU303E, GLU303G, GLU331E, GLU331G, GLU343E, GLU343G, GLU363E, GLU363G, GLU372E, GLU372G, GLU383E, GLU383G, GLU385E, GLU385G, GLU395E, GLU395G, GLU396E, GLU396G, GLY178E, GLY178G, GLY199E, GLY199G, GLY200E, GLY200G, GLY275E, GLY275G, GLY294E, GLY294G, GLY297E, GLY297G, GLY314E, GLY314G, GLY320E, GLY344E, GLY344G, GLY354E, GLY354G, HIS18E, HIS18G, HIS273E, HIS273G, HIS28E, HIS28G, HIS378E, HIS378G, ILE12E, ILE12G, ILE180E, ILE180G, ILE270E, ILE270G, ILE298E, ILE298G, ILE300E, ILE300G, ILE312E, ILE312G, ILE313E, ILE313G, ILE334G, ILE34E, ILE34G, ILE380E, ILE380G, LEU179E, LEU179G, LEU26E, LEU26G, LEU296E, LEU296G, LEU307E, LEU307G, LEU32E, LEU32G, LEU330E, LEU330G, LEU352E, LEU352G, LEU379E, LEU379G, LEU393E, LEU393G, LEU397E, LEU397G, LYS135E, LYS135G, LYS29E, LYS29G, LYS304E, LYS304G, LYS310E, LYS310G, LYS335E, LYS335G, LYS336E, LYS336G, LYS366G, LYS392E, LYS392G, MET21G, MET311E, MET311G, MET329E, MET329G, MET333G, MET376E, MET376G, MET388E, MET388G, PHE201E, PHE25E, PHE25G, PHE279E, PHE279G, PHE306E, PHE306G, PHE389E, PHE389G, PHE394E, PHE394G, PRO301E, PRO301G, PRO337E, PRO337G, PRO339E, PRO339G, PRO38E, PRO38G, SER181E, SER181G, SER332E, SER332G, SER345E, SER345G, SER36E, SER36G, SER401E, SER401G, THR24E, THR24G, THR327E, THR327G, THR340E, THR340G, TYR174E, TYR174G, TYR369E, TYR369G, VAL276E, VAL276G, VAL291E, VAL291G, VAL305E, VAL305G, VAL347E, VAL347G, VAL351E, VAL351G
• E-H: ARG31E, ARG31H, ARG391E, ARG391H, ARG399E, ARG399H, ASP23E, ASP23H, GLU27E, GLU27H, THR24E, THR24H
• F-G: ARG391F, ARG391G, ARG399F, ARG399G, ASP23F, ASP23G, GLU27F, GLU27G, LYS392F, LYS392G, THR24F, THR24G
• F-H: ALA19F, ALA19H, ALA22F, ALA22H, ALA292F, ALA292H, ALA302F, ALA302H, ALA308F, ALA308H, ALA319F, ALA319H, ALA326F, ALA326H, ALA342F, ALA342H, ALA348F, ALA348H, ALA350F, ALA350H, ALA355H, ALA37F, ALA37H, ALA381F, ALA381H, ALA384F, ALA384H, ALA386F, ALA386H, ALA387F, ALA387H, ALA398F, ALA398H, ALA400F, ALA400H, ARG277F, ARG277H, ARG293F, ARG293H, ARG315F, ARG315H, ARG318F, ARG318H, ARG31F, ARG31H, ARG338F, ARG338H, ARG341F, ARG341H, ARG375F, ARG375H, ARG382F, ARG382H, ARG391F, ARG391H, ARG399F, ARG399H, ARG444F, ASN198F, ASN198H, ASN209F, ASN209H, ASN272F, ASN272H, ASN317F, ASN317H, ASN349F, ASN349H, ASP176F, ASP176H, ASP177F, ASP177H, ASP23F, ASP23H, ASP280F, ASP280H, ASP295F, ASP295H, ASP33F, ASP33H, ASP346F, ASP346H, ASP353F, ASP353H, ASP35F, ASP35H, CYS30F, CYS30H, CYS316F, CYS316H, CYS325F, CYS325H, GLN16F, GLN16H, GLN309F, GLN309H, GLN328F, GLN328H, GLN377F, GLN377H, GLU274F, GLU274H, GLU27F, GLU27H, GLU299F, GLU299H, GLU303F, GLU303H, GLU331F, GLU331H, GLU343F, GLU343H, GLU363F, GLU363H, GLU372F, GLU372H, GLU383F, GLU383H, GLU385F, GLU385H, GLU395F, GLU395H, GLU396F, GLU396H, GLY178F, GLY178H, GLY199F, GLY199H, GLY200F, GLY200H, GLY275F, GLY275H, GLY294F, GLY294H, GLY297F, GLY297H, GLY314F, GLY314H, GLY320F, GLY344F, GLY344H, GLY354F, GLY354H, HIS18F, HIS18H, HIS273F, HIS273H, HIS28F, HIS28H, HIS378F, HIS378H, ILE12F, ILE12H, ILE180F, ILE180H, ILE270F, ILE270H, ILE298F, ILE298H, ILE300F, ILE300H, ILE312F, ILE312H, ILE313F, ILE313H, ILE334F, ILE334H, ILE34F, ILE34H, ILE380F, ILE380H, LEU179F, LEU179H, LEU26F, LEU26H, LEU296F, LEU296H, LEU307F, LEU307H, LEU32F, LEU32H, LEU330F, LEU330H, LEU352F, LEU352H, LEU379F, LEU379H, LEU393F, LEU393H, LEU397F, LEU397H, LYS135F, LYS135H, LYS29F, LYS29H, LYS304F, LYS304H, LYS310F, LYS310H, LYS335F, LYS335H, LYS336F, LYS336H, LYS366F, LYS366H, LYS392F, LYS392H, MET21F, MET21H, MET311F, MET311H, MET329F, MET329H, MET333F, MET333H, MET376F, MET376H, MET388F, MET388H, PHE201H, PHE25F, PHE25H, PHE279H, PHE2F, PHE2H, PHE306F, PHE306H, PHE389F, PHE389H, PHE394F, PHE394H, PRO211H, PRO301F, PRO301H, PRO337F, PRO337H, PRO339F, PRO339H, PRO38F, PRO38H, SER181F, SER181H, SER332F, SER332H, SER345F, SER345H, SER36F, SER36H, SER401F, SER401H, THR24F, THR24H, THR327F, THR327H, THR340F, THR340H, TYR174F, TYR174H, TYR369F, TYR369H, VAL175H, VAL276F, VAL276H, VAL291F, VAL291H, VAL305F, VAL305H, VAL323H, VAL347F, VAL347H, VAL351F, VAL351H
• G-H: ALA20G, ALA20H, ALA22G, ALA22H, ALA398G, ALA398H, ALA400G, ALA400H, ALA410G, ALA410H, ALA412G, ALA412H, ALA418G, ALA418H, ALA424G, ALA424H, ALA482G, ALA482H, ARG391G, ARG391H, ARG399G, ARG399H, ARG442G, ARG442H, ARG446H, ARG515G, ARG515H, ARG525G, ARG525H, ASN490H, ASN522G, ASN522H, ASP23G, ASP23H, ASP406G, ASP406H, ASP486G, ASP486H, ASP506G, ASP506H, CYS422G, CYS422H, GLN13G, GLN403G, GLN403H, GLN439G, GLN439H, GLU27G, GLU27H, GLU395G, GLU395H, GLU396G, GLU396H, GLU409G, GLU409H, GLU417G, GLU417H, GLU483G, GLY414G, GLY414H, GLY505G, GLY505H, GLY513G, GLY513H, ILE509G, ILE509H, LEU17G, LEU17H, LEU397G, LEU397H, LEU407G, LEU407H, LEU423G, LEU423H, LEU511G, LEU511H, LYS392G, LYS392H, LYS421G, LYS421H, MET21G, MET21H, MET408G, MET408H, MET411G, MET411H, MET413G, MET413H, MET524G, MET524H, PHE394G, PHE394H, PHE520G, PHE520H, PRO528G, PRO528H, PRO530H, SER401G, SER401H, SER402G, SER402H, SER404G, SER404H, SER415G, SER415H, SER419G, SER419H, SER518G, THR24H, THR405G, THR405H, THR512G, THR512H, THR521G, THR521H, THR523G, THR523H, TRP481G, TRP481H, TRP514G, TRP514H, TYR420G, TYR420H, TYR443G, TYR443H, VAL416G, VAL416H, VAL485G, VAL485H, VAL489G, VAL489H, VAL507G, VAL507H, VAL508G, VAL508H, VAL510G, VAL510H, VAL526G, VAL526H, VAL527G, VAL527H