2G4C

crystal structure of human dna polymerase gamma accessory subunit

• Total interactions analyzed: 6
• Total true interactions: 5
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 277
  • Norm. En. per Res.: -3.0363
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.2963	-0.2963	6	0	0	77	0	0	0
A-C	-98.5615	-153.1054	-587.544	-839.2109	277	61	32	28949	11	85	91
B-C	0.0	-1.6232	-128.023	-129.6462	70	13	1	5371	1	17	24
B-D	-99.2289	-153.2379	-588.587	-841.0538	277	57	32	28804	11	85	90
C-D	0.0	-0.9955	-11.4838	-12.4793	30	0	0	867	0	16	10

Interface residues

• A-B: ARG154A, ARG284B, ASN249B, GLN84A, LYS285B, SER271B
• A-C: ALA112A, ALA130A, ALA130C, ALA144A, ALA144C, ALA150A, ALA150C, ALA209A, ALA209C, ARG107A, ARG107C, ARG122A, ARG122C, ARG146A, ARG146C, ARG154A, ARG154C, ARG182A, ARG182C, ARG203A, ARG203C, ARG325A, ARG396A, ARG396C, ARG75A, ARG75C, ARG76A, ARG76C, ASN173A, ASN173C, ASN195A, ASN195C, ASN201A, ASN201C, ASN404A, ASN404C, ASN409A, ASN409C, ASN484C, ASP129A, ASP129C, ASP142A, ASP142C, ASP198A, ASP198C, ASP343A, ASP343C, CYS196A, CYS196C, CYS214A, CYS214C, CYS95A, CYS95C, GLN124A, GLN124C, GLN158A, GLN158C, GLN166C, GLN210A, GLN210C, GLN74A, GLN74C, GLN85A, GLN85C, GLU105A, GLU105C, GLU123A, GLU123C, GLU151A, GLU151C, GLU155A, GLU155C, GLU165A, GLU165C, GLU172A, GLU172C, GLU191A, GLU191C, GLU233A, GLU233C, GLU408A, GLU408C, GLU419A, GLU419C, GLY100A, GLY100C, GLY103A, GLY103C, GLY136A, GLY136C, GLY141A, GLY141C, GLY179A, GLY179C, GLY207A, GLY207C, GLY212A, GLY212C, GLY232A, GLY232C, GLY410A, GLY410C, GLY416A, GLY416C, GLY81A, GLY81C, GLY94A, GLY94C, GLY98A, GLY98C, HIS132A, HIS132C, HIS133A, HIS133C, HIS192A, HIS192C, HIS77A, HIS77C, HIS96A, HIS96C, ILE156A, ILE156C, ILE211A, ILE211C, ILE231A, ILE231C, ILE381A, ILE381C, ILE411A, ILE411C, LEU102A, LEU102C, LEU106A, LEU106C, LEU131A, LEU131C, LEU139C, LEU147A, LEU147C, LEU153A, LEU153C, LEU157A, LEU157C, LEU167A, LEU167C, LEU171A, LEU171C, LEU175A, LEU175C, LEU181A, LEU181C, LEU197A, LEU197C, LEU199A, LEU199C, LEU208A, LEU208C, LEU406A, LEU407A, LEU407C, LEU418A, LEU418C, LEU79A, LEU79C, LEU86A, LYS108A, LYS108C, LYS134A, LYS134C, LYS160C, LYS164A, LYS164C, LYS176A, LYS176C, LYS180A, LYS180C, LYS229A, LYS229C, LYS234A, LYS234C, LYS431A, LYS483C, MET346C, MET421C, MET435A, MET435C, PHE121A, PHE121C, PHE126A, PHE126C, PHE145A, PHE145C, PHE170A, PHE170C, PHE215A, PHE215C, PHE403A, PHE403C, PHE99A, PHE99C, PRO101A, PRO101C, PRO127A, PRO127C, PRO135A, PRO135C, PRO140A, PRO140C, PRO217A, PRO217C, PRO380C, PRO415A, PRO415C, PRO97A, PRO97C, SER143A, SER143C, SER149A, SER149C, SER163A, SER163C, SER178A, SER178C, SER230A, SER230C, SER412A, SER412C, SER80A, SER80C, SER82A, SER82C, THR116A, THR116C, THR152A, THR152C, THR169A, THR169C, THR177C, THR235A, THR235C, THR420A, THR420C, TRP114A, TRP115A, TRP115C, TRP414A, TRP414C, TYR193C, TYR206A, TYR206C, TYR417A, TYR417C, VAL104A, VAL104C, VAL119A, VAL119C, VAL120A, VAL120C, VAL125A, VAL125C, VAL128A, VAL128C, VAL148A, VAL148C, VAL168A, VAL168C, VAL174A, VAL174C, VAL194A, VAL194C, VAL200A, VAL200C, VAL213A, VAL213C, VAL218C, VAL413A, VAL413C
• B-C: ARG122B, ARG246B, ARG257B, ARG259B, ARG284C, ARG325C, ASN173C, ASN249B, ASN287B, ASN318C, ASN330C, ASN484B, ASP253B, ASP277B, ASP280C, CYS278B, GLN124B, GLN250B, GLN261B, GLN279B, GLU113B, GLU172C, GLU281C, GLU282C, GLY141C, GLY317C, HIS187C, HIS258B, HIS309C, HIS313C, HIS323C, LEU138C, LEU139C, LEU252B, LEU256B, LEU260B, LEU311C, LEU312C, LEU322C, LYS176C, LYS202C, LYS265B, LYS285B, LYS321C, LYS477B, LYS483B, MET314C, PHE121B, PHE254B, PHE266B, PRO137C, PRO140C, PRO316C, SER117B, SER275B, SER276B, SER320C, SER480B, SER481B, THR116B, THR169C, THR247B, TRP251B, TRP255B, TRP262B, TYR315C, VAL118B, VAL194C, VAL319C, VAL485B
• B-D: ALA112B, ALA130B, ALA130D, ALA144B, ALA144D, ALA150B, ALA150D, ALA209B, ALA209D, ARG107B, ARG107D, ARG122B, ARG122D, ARG146B, ARG146D, ARG154B, ARG154D, ARG182B, ARG182D, ARG203B, ARG203D, ARG325B, ARG396B, ARG396D, ARG75B, ARG75D, ARG76B, ARG76D, ASN173B, ASN173D, ASN195B, ASN195D, ASN201B, ASN201D, ASN404B, ASN404D, ASN409B, ASN409D, ASN484D, ASP129B, ASP129D, ASP142B, ASP142D, ASP198B, ASP198D, ASP343B, ASP343D, CYS196B, CYS196D, CYS214B, CYS214D, CYS95B, CYS95D, GLN124B, GLN124D, GLN158B, GLN158D, GLN166D, GLN210B, GLN210D, GLN74B, GLN74D, GLN85B, GLN85D, GLU105B, GLU105D, GLU123B, GLU123D, GLU151B, GLU151D, GLU155B, GLU155D, GLU165B, GLU165D, GLU172B, GLU172D, GLU191B, GLU191D, GLU233B, GLU233D, GLU408B, GLU408D, GLU419B, GLU419D, GLY100B, GLY100D, GLY103B, GLY103D, GLY136B, GLY136D, GLY141B, GLY141D, GLY179B, GLY179D, GLY207B, GLY207D, GLY212B, GLY212D, GLY232B, GLY232D, GLY410B, GLY410D, GLY416B, GLY416D, GLY81B, GLY81D, GLY94B, GLY94D, GLY98B, GLY98D, HIS132B, HIS132D, HIS133B, HIS133D, HIS192B, HIS192D, HIS77B, HIS77D, HIS96B, HIS96D, ILE156B, ILE156D, ILE211B, ILE211D, ILE231B, ILE231D, ILE381B, ILE381D, ILE411B, ILE411D, LEU102B, LEU102D, LEU106B, LEU106D, LEU131B, LEU131D, LEU139D, LEU147B, LEU147D, LEU153B, LEU153D, LEU157B, LEU157D, LEU167B, LEU167D, LEU171B, LEU171D, LEU175B, LEU175D, LEU181B, LEU181D, LEU197B, LEU197D, LEU199B, LEU199D, LEU208B, LEU208D, LEU406B, LEU407B, LEU407D, LEU418B, LEU418D, LEU79B, LEU79D, LEU86B, LYS108B, LYS108D, LYS134B, LYS134D, LYS160D, LYS164B, LYS164D, LYS176B, LYS176D, LYS180B, LYS180D, LYS229B, LYS229D, LYS234B, LYS234D, LYS431B, LYS483D, MET346D, MET421D, MET435B, MET435D, PHE121B, PHE121D, PHE126B, PHE126D, PHE145B, PHE145D, PHE170B, PHE170D, PHE215B, PHE215D, PHE403B, PHE403D, PHE99B, PHE99D, PRO101B, PRO101D, PRO127B, PRO127D, PRO135B, PRO135D, PRO140B, PRO140D, PRO217B, PRO217D, PRO380D, PRO415B, PRO415D, PRO97B, PRO97D, SER143B, SER143D, SER149B, SER149D, SER163B, SER163D, SER178B, SER178D, SER230B, SER230D, SER412B, SER412D, SER80B, SER80D, SER82B, SER82D, THR116B, THR116D, THR152B, THR152D, THR169B, THR169D, THR177D, THR235B, THR235D, THR420B, THR420D, TRP114B, TRP115B, TRP115D, TRP414B, TRP414D, TYR193D, TYR206B, TYR206D, TYR417B, TYR417D, VAL104B, VAL104D, VAL119B, VAL119D, VAL120B, VAL120D, VAL125B, VAL125D, VAL128B, VAL128D, VAL148B, VAL148D, VAL168B, VAL168D, VAL174B, VAL174D, VAL194B, VAL194D, VAL200B, VAL200D, VAL213B, VAL213D, VAL218D, VAL413B, VAL413D
• C-D: ARG246C, ARG284C, ARG328C, ASN249C, ASN330C, ASN404D, ASP308C, GLN250C, GLN279C, GLN397D, GLN400D, GLU394D, GLU405D, GLU408D, GLY401D, HIS323C, LEU393D, LEU448D, LYS285C, LYS329C, PRO244C, PRO245C, SER248C, SER320C, SER469D, THR247C, VAL319C, VAL331C, VAL332C, VAL398D