2FYU

crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

• Total interactions analyzed: 55
• Total true interactions: 24
• Strongest Interaction:
  • Chains: A-G
  • Int. Res.: 70
  • Norm. En. per Res.: -6.7317
• Hub Node: A(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-134.1549	-77.5983	-571.111	-782.8642	228	25	10	21958	6	55	53
A-C	-32.7544	-40.2892	-84.1773	-157.2209	51	9	0	3511	4	18	17
A-D	-4.3225	4.9898	-21.3329	-20.6655	33	1	1	1162	0	10	12
A-F	0.0	6.697	-0.2735	6.4235	10	0	0	90	0	9	9
A-G	-131.2874	-53.821	-286.109	-471.2173	70	14	2	9312	2	20	13
A-I	-35.2526	-13.2076	-312.841	-361.3013	133	19	4	13271	1	22	37
A-J	-42.159	-6.8756	-74.8715	-123.9061	29	5	0	2415	0	4	7
A-K	0.0	-7.6548	-90.446	-98.1008	36	6	0	3643	0	9	7
B-I	-63.5259	-2.739	-539.925	-606.1899	207	33	18	23041	1	18	20
B-K	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	1
C-D	-57.3614	-85.6831	-461.233	-604.2776	156	28	11	17531	9	36	37
C-E	-13.4491	2.2744	-273.153	-284.3278	115	13	5	11948	0	12	20
C-F	-29.3746	26.2762	-346.569	-349.6674	112	12	7	13661	2	38	30
C-G	-35.5887	-41.5387	-307.93	-385.0574	116	9	7	11217	4	17	15
C-J	0.0	0.0	-0.0053	-0.0053	2	0	0	4	0	0	0
D-E	0.0	0.0	-0.0021	-0.0021	2	0	0	1	0	2	4
D-F	-25.8043	-17.9991	-91.1673	-134.9708	38	2	1	3444	1	9	13
D-G	-69.0055	-12.9061	-208.494	-290.4056	58	10	4	7530	1	14	17
D-H	-34.1842	7.3866	-263.657	-290.4546	103	5	5	11586	0	16	27
D-J	-44.966	-73.3726	-231.253	-349.5916	75	6	6	8551	3	52	38
F-G	-9.1693	-57.4808	-85.1843	-151.8344	49	3	2	3565	2	11	24
G-H	-6.5218	-34.3032	-23.7893	-64.6143	17	0	0	958	2	19	7
G-J	0.0	0.0	-0.011	-0.011	2	0	0	7	0	0	0
J-K	0.0	18.4099	-150.815	-132.4051	56	3	8	6312	0	5	4

Interface residues

• A-B: ALA101A, ALA149B, ALA151B, ALA200A, ALA275A, ALA281B, ALA288A, ALA291B, ALA295A, ALA299A, ALA2A, ALA359B, ALA360B, ALA364A, ALA366B, ALA42B, ALA44B, ALA5A, ALA63A, ALA72B, ALA74A, ALA7A, ALA84A, ALA88A, ALA91B, ALA96A, ARG113B, ARG287B, ARG356A, ARG362A, ARG46B, ARG87B, ASN141A, ASN290B, ASN359A, ASN362B, ASN363A, ASN40B, ASN73A, ASN87A, ASP105A, ASP114B, ASP115B, ASP147B, ASP281A, ASP356B, ASP370A, CYS111B, CYS282A, CYS35A, GLN126A, GLN136A, GLN143B, GLN153B, GLN15A, GLN22B, GLN297B, GLN29A, GLN305A, GLN32A, GLN358B, GLN6A, GLN9A, GLU110B, GLU130A, GLU136B, GLU137A, GLU13A, GLU140A, GLU168A, GLU204A, GLU28A, GLU353A, GLU373B, GLU376B, GLU396A, GLU39B, GLU60A, GLU76A, GLU78A, GLU80A, GLU90B, GLY201A, GLY202A, GLY210B, GLY278A, GLY282B, GLY285A, GLY286A, GLY287A, GLY288B, GLY357A, GLY367B, GLY371A, GLY377B, GLY56A, GLY83A, GLY88B, GLY93B, GLY94B, HIS205A, HIS20B, HIS213B, HIS277B, HIS279A, HIS284B, HIS289A, HIS368A, HIS61A, HIS85A, ILE116A, ILE134A, ILE146B, ILE399A, ILE85B, ILE89B, ILE99A, LEU102A, LEU112B, LEU119B, LEU140B, LEU203A, LEU209B, LEU290A, LEU355A, LEU360A, LEU361A, LEU364B, LEU365A, LEU369A, LEU369B, LEU392A, LEU399B, LEU62A, LEU71B, LEU75A, LEU75B, LEU86A, LEU8A, LEU96B, LYS100A, LYS104A, LYS148B, LYS286B, LYS302A, LYS358A, LYS361B, LYS363B, LYS365B, LYS65A, LYS77A, LYS84B, LYS95B, MET370B, MET82A, PHE378B, PHE58A, PHE64A, PHE83B, PRO12A, PRO142B, PRO18B, PRO19B, PRO214B, PRO21B, PRO283B, PRO293A, PRO306B, PRO33A, PRO355B, PRO374A, PRO395B, PRO43B, SER103A, SER10A, SER212B, SER289B, SER291A, SER292A, SER293B, SER296A, SER30A, SER31A, SER352A, SER367A, SER371B, SER374B, SER375B, SER396B, SER45B, SER73B, SER74B, SER81A, SER81B, SER82B, SER90A, THR1A, THR283A, THR292B, THR34A, THR36A, THR372A, THR373A, THR3A, THR76B, THR86B, TYR280A, TYR284A, TYR368B, TYR41B, TYR4A, TYR57A, TYR89A, TYR97A, TYR98A, VAL116B, VAL11A, VAL133A, VAL150B, VAL17B, VAL211B, VAL215B, VAL285B, VAL366A, VAL372B, VAL59A, VAL79A, VAL92B
• A-C: ARG244A, ARG436A, ARG438A, ARG445A, ARG5C, ASN15C, ASN301A, ASN3C, ASN435A, ASP20C, ASP214C, ASP216C, ASP332A, ASP333A, ASP433A, GLN240A, GLN430A, GLU429A, HIS221C, ILE19C, ILE218C, ILE226C, ILE297A, ILE331A, ILE437A, ILE4C, LEU21C, LEU303A, LEU431A, LEU444A, LYS217C, LYS6C, MET329A, MET334A, MET335A, PHE18C, PHE220C, PHE336A, PHE442A, PRO219C, PRO222C, PRO22C, PRO432A, SER330A, SER439A, THR225C, THR2C, TYR223C, TYR434A, VAL215C, VAL337A
• A-D: ALA236D, ARG233D, ARG238D, ARG244A, ARG436A, ARG438A, ASN435A, ASP142A, ASP433A, CYS242A, GLN240A, GLU245A, HIS225D, HIS243A, ILE241A, LEU230D, LEU235D, LYS223D, LYS226D, LYS231D, LYS234D, PHE442A, PRO239D, PRO240D, SER171A, SER228D, SER239A, SER439A, TRP227D, TYR152A, TYR237D, TYR434A, VAL229D
• A-F: ARG244A, ASP246A, ASP56F, CYS242A, GLU245A, GLU52F, GLY247A, LYS63F, TYR55F, VAL59F
• A-G: ALA155A, ALA421A, ALA423A, ARG11G, ARG235A, ARG244A, ARG436A, ARG438A, ARG9G, ASN435A, ASP246A, ASP327A, ASP332A, ASP417A, ASP433A, CYS242A, CYS419A, GLN159A, GLN23G, GLN240A, GLN3G, GLN418A, GLN430A, GLU22G, GLU245A, GLU429A, GLY238A, GLY247A, GLY424A, GLY426A, GLY5G, HIS12G, HIS243A, HIS328A, HIS6G, ILE14G, ILE241A, ILE331A, ILE428A, LEU18G, LEU248A, LEU431A, LEU7G, MET329A, MET441A, PHE21G, PHE236A, PHE425A, PHE442A, PHE4G, PRO20G, PRO249A, PRO420A, PRO427A, PRO432A, SER17G, SER19G, SER239A, SER330A, SER439A, THR156A, THR15G, THR237A, THR8G, TYR152A, TYR16G, TYR434A, VAL10G, VAL13G, VAL422A
• A-I: ALA17I, ALA251A, ALA269A, ALA275A, ALA32I, ALA33I, ALA364A, ALA36I, ARG146A, ARG20I, ARG356A, ARG381A, ARG388A, ARG389A, ARG398A, ARG47I, ARG52I, ARG56I, ASN141A, ASN267A, ASN274A, ASN311A, ASN359A, ASN363A, ASN87A, ASP132A, ASP142A, ASP147A, ASP281A, ASP327A, ASP378A, ASP44I, CYS282A, CYS313A, CYS326A, CYS51I, GLN136A, GLN139A, GLN271A, GLN305A, GLN308A, GLN31I, GLU130A, GLU137A, GLU140A, GLU377A, GLU39I, GLU53I, GLU80A, GLY21I, GLY278A, GLY285A, GLY286A, GLY380A, GLY57I, HIS252A, HIS264A, HIS279A, HIS323A, HIS368A, HIS61A, HIS85A, HIS94A, ILE134A, ILE312A, ILE379A, ILE390A, ILE399A, LEU135A, LEU138A, LEU15I, LEU248A, LEU250A, LEU26I, LEU290A, LEU360A, LEU361A, LEU365A, LEU369A, LEU383A, LEU384A, LEU43I, LEU45I, LEU50I, LEU55I, LYS46I, LYS65A, MET145A, PHE150A, PHE307A, PHE310A, PHE324A, PRO249A, PRO35I, PRO374A, PRO41I, SER144A, SER16I, SER19I, SER291A, SER292A, SER306A, SER367A, SER382A, SER38I, SER40I, SER48I, SER54I, THR143A, THR18I, THR283A, THR309A, THR37I, THR385A, TRP262A, TRP395A, TRP40A, TYR280A, TYR284A, TYR386A, VAL133A, VAL149A, VAL14I, VAL22I, VAL268A, VAL272A, VAL30I, VAL325A, VAL34I, VAL366A, VAL375A, VAL42I, VAL49I
• A-J: ALA21J, ARG15J, ARG16J, ARG408A, ARG438A, ARG445A, ASP417A, CYS346A, CYS411A, GLN418A, GLU409A, LEU444A, LYS413A, MET441A, PHE14J, PHE20J, PHE415A, PHE442A, PHE446A, SER18J, SER412A, THR17J, THR19J, THR347A, TRP443A, TYR10J, TYR414A, TYR416A, VAL410A
• A-K: ALA14K, ALA21K, ALA349A, ALA404A, ARG11K, ARG15K, ARG344A, ARG356A, ARG405A, ARG408A, ARG445A, ARG9K, ASN16K, CYS346A, GLN12K, GLU351A, GLU353A, LEU13K, LEU23K, LEU444A, MET343A, PHE446A, PRO19K, PRO293A, PRO8K, SER348A, SER352A, THR20K, THR347A, THR350A, TRP17K, TRP24K, TRP443A, TYR10K, TYR416A, VAL354A
• B-I: ALA106B, ALA12I, ALA149B, ALA151B, ALA157B, ALA17I, ALA23I, ALA255B, ALA256B, ALA25I, ALA262B, ALA263B, ALA267B, ALA269B, ALA271B, ALA281B, ALA291B, ALA300B, ALA311B, ALA314B, ALA32I, ALA33I, ALA36I, ALA386B, ALA388B, ALA389B, ALA5I, ALA6I, ALA72B, ARG102B, ARG20I, ARG27I, ARG287B, ARG47I, ARG52I, ARG70B, ARG7I, ASN104B, ASN154B, ASN270B, ASN290B, ASN313B, ASP147B, ASP250B, ASP308B, ASP380B, ASP44I, CYS51I, GLN143B, GLN153B, GLN156B, GLN276B, GLN297B, GLN305B, GLN31I, GLN329B, GLN385B, GLN401B, GLU103B, GLU110B, GLU161B, GLU268B, GLU376B, GLU381B, GLU39I, GLU53I, GLU90B, GLY21I, GLY24I, GLY265B, GLY280B, GLY282B, GLY288B, GLY320B, GLY367B, GLY377B, GLY383B, GLY390B, GLY93B, GLY94B, GLY9I, HIS158B, HIS164B, HIS254B, HIS277B, HIS284B, HIS304B, HIS67B, ILE146B, ILE160B, ILE264B, ILE327B, ILE402B, ILE85B, ILE89B, LEU119B, LEU140B, LEU144B, LEU152B, LEU15I, LEU163B, LEU172B, LEU176B, LEU252B, LEU26I, LEU295B, LEU29I, LEU2I, LEU321B, LEU364B, LEU369B, LEU379B, LEU387B, LEU399B, LEU43I, LEU45I, LEU55I, LEU68B, LEU69B, LEU71B, LEU96B, LYS286B, LYS363B, LYS365B, LYS46I, LYS95B, MET105B, MET1I, PHE11I, PHE272B, PHE307B, PHE312B, PHE322B, PHE324B, PHE378B, PHE50B, PRO10I, PRO13I, PRO155B, PRO283B, PRO28I, PRO306B, PRO35I, PRO395B, PRO41I, SER100B, SER16I, SER175B, SER19I, SER251B, SER266B, SER273B, SER289B, SER293B, SER310B, SER315B, SER317B, SER319B, SER371B, SER384B, SER38I, SER391B, SER3I, SER40I, SER48I, SER54I, SER55B, SER66B, SER73B, SER74B, SER8I, SER97B, THR101B, THR108B, THR18I, THR326B, THR37I, THR393B, THR397B, THR86B, THR99B, TYR107B, TYR177B, TYR296B, TYR316B, TYR325B, TYR368B, TYR392B, VAL109B, VAL126B, VAL14I, VAL150B, VAL159B, VAL22I, VAL274B, VAL285B, VAL309B, VAL30I, VAL34I, VAL372B, VAL382B, VAL398B, VAL405B, VAL42I, VAL49I, VAL4I, VAL98B
• B-K: ARG87B, ARG9K
• C-D: ALA119D, ALA193D, ALA194D, ALA221D, ALA232C, ALA238C, ALA23C, ALA246C, ALA47D, ARG102D, ARG118D, ARG120D, ARG191D, ARG201D, ARG203D, ARG224D, ARG233D, ARG49D, ARG71C, ARG80C, ASN255C, ASN260C, ASN263C, ASN26C, ASN32C, ASN74C, ASP112D, ASP199D, ASP216C, ASP228C, ASP248C, ASP252C, ASP254C, ASP2D, ASP44D, ASP72C, CYS70C, GLN137C, GLU195D, GLU197D, GLU344C, GLU4D, GLY122D, GLY123D, GLY16D, GLY205D, GLY213D, GLY231C, GLY251C, HIS121D, HIS198D, HIS200D, HIS221C, HIS225D, HIS267C, HIS50D, HIS68C, HIS6D, ILE116D, ILE218C, ILE226C, ILE229C, ILE236C, ILE268C, ILE27C, ILE69C, ILE78C, LEU109D, LEU113D, LEU17D, LEU18D, LEU190D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU216D, LEU218D, LEU230C, LEU230D, LEU233C, LEU234C, LEU235C, LEU235D, LEU237C, LEU239C, LEU241C, LEU242C, LEU244C, LEU249C, LEU262C, LYS202D, LYS207D, LYS217C, LYS223D, LYS226D, LYS227C, LYS231D, LYS269C, MET204D, MET208D, MET211D, MET212D, MET222D, MET240C, MET43D, MET82C, PHE220C, PHE245C, PHE63C, PRO111D, PRO154D, PRO196D, PRO217D, PRO219C, PRO222C, PRO247C, PRO24C, PRO253C, PRO258C, PRO265C, PRO266C, PRO98D, SER114D, SER19D, SER228D, SER25C, SER28C, SER29C, SER64C, SER65C, THR225C, THR257C, THR60C, THR61C, THR67C, TRP192D, TRP227D, TRP77C, TYR115D, TYR220D, TYR223C, TYR224C, TYR256C, TYR45D, TYR75C, TYR81C, TYR90D, VAL117D, VAL215C, VAL219D, VAL229D, VAL243C, VAL46D, VAL66C
• C-E: ALA143C, ALA148E, ALA152C, ALA173C, ALA176E, ALA279C, ALA64E, ALA70E, ALA88E, ARG118E, ARG177C, ARG282C, ARG92E, ASN148C, ASN159C, ASN260C, ASN263C, ASN286C, ASP171C, ASP67E, CYS139E, CYS144E, CYS158E, CYS160E, GLU162C, GLU181E, GLU344C, GLY137E, GLY142C, GLY143E, GLY162E, GLY166C, GLY167C, GLY174E, GLY289C, GLY290C, GLY93E, HIS141E, HIS161E, HIS164E, HIS267C, ILE136E, ILE146C, ILE147E, ILE164C, ILE268C, ILE284C, ILE348C, LEU142E, LEU149C, LEU150C, LEU178E, LEU262C, LEU281C, LEU288C, LEU294C, LEU69E, LEU96E, LYS172C, LYS173E, LYS269C, LYS287C, LYS90E, LYS94E, MET62E, MET71E, PHE140C, PHE168C, PHE181C, PHE58E, PHE89E, PHE97E, PRO146E, PRO159E, PRO175E, PRO177E, PRO261C, PRO265C, PRO266C, PRO270C, PRO285C, PRO342C, PRO95E, SER151C, SER163E, SER169C, SER283C, SER56E, SER60E, SER61E, SER63E, SER65E, SER72E, THR140E, THR144C, THR147C, THR158C, THR174C, THR264C, TRP141C, TRP163C, TRP165C, TRP91E, TYR157E, TYR278C, VAL138E, VAL145C, VAL145E, VAL161C, VAL170C, VAL291C, VAL343C, VAL55E, VAL59E, VAL68E
• C-F: ALA23F, ALA24F, ALA369C, ALA65F, ARG17F, ARG313C, ARG318C, ARG33F, ARG58F, ARG61F, ARG64F, ARG71F, ASN206C, ASN207C, ASN22F, ASN26C, ASN27F, ASN374C, ASN40F, ASP214C, ASP216C, ASP34F, ASP35F, ASP42F, ASP56F, ASP67F, ASP86F, CYS323C, GLN312C, GLN322C, GLN72F, GLN73F, GLU14F, GLU373C, GLU39F, GLU84F, GLU91F, GLY105C, GLY15F, GLY210C, GLY25F, GLY370C, HIS308C, HIS38F, ILE16F, ILE211C, ILE218C, ILE27C, ILE372C, ILE37F, ILE47F, ILE62F, ILE74F, ILE98F, LEU13F, LEU29F, LEU31F, LEU320C, LEU376C, LEU377C, LEU66F, LEU68F, LEU90F, LEU94F, LYS18F, LYS217C, LYS227C, LYS28F, LYS311C, LYS375C, LYS378C, LYS44F, LYS63F, LYS95F, MET315C, MET316C, MET32F, MET70F, PHE109C, PHE26F, PHE317C, PHE60F, PRO208C, PRO24C, PRO319C, SER106C, SER212C, SER213C, SER25C, SER28C, SER29C, SER310C, SER314C, SER321C, SER69F, SER88F, THR108C, THR203C, THR209C, THR36F, TRP19F, TRP30C, TRP379C, TYR104C, TYR20F, TYR21F, TYR224C, TYR55F, TYR83F, VAL215C, VAL43F, VAL59F
• C-G: ALA23C, ALA327C, ALA330C, ALA354C, ALA43G, ALA49G, ALA54G, ARG11G, ARG2G, ARG318C, ARG40G, ARG47G, ARG9G, ASN15C, ASN16C, ASN206C, ASP20C, ASP214C, ASP216C, ASP331C, CYS323C, CYS44G, GLN322C, GLN341C, GLN3G, GLN64G, GLU202C, GLU344C, GLU65G, GLU67G, GLY1G, GLY204C, GLY5G, GLY62G, HIS201C, HIS221C, HIS267C, HIS345C, HIS6G, ILE19C, ILE218C, ILE338C, ILE348C, ILE350C, ILE45G, LEU198C, LEU200C, LEU21C, LEU320C, LEU324C, LEU328C, LEU332C, LEU333C, LEU335C, LEU353C, LEU357C, LEU361C, LEU46G, LEU57G, LEU7G, LYS217C, LYS68G, LYS6C, LYS70G, MET315C, MET316C, PHE109C, PHE199C, PHE220C, PHE317C, PHE325C, PHE4G, PHE52G, PHE55G, PHE66G, PRO20G, PRO219C, PRO222C, PRO22C, PRO24C, PRO319C, PRO342C, PRO346C, PRO50G, PRO51G, SER205C, SER212C, SER213C, SER28C, SER29C, SER321C, SER69G, THR15G, THR203C, THR334C, THR336C, THR349C, THR60G, THR63G, THR8G, TRP326C, TRP337C, TRP61G, TYR103C, TYR223C, TYR347C, TYR56G, TYR59G, VAL10G, VAL13G, VAL215C, VAL329C, VAL343C, VAL48G, VAL53G, VAL58G
• C-J: PHE245C, TYR43J
• D-E: GLU99D, LYS90E
• D-F: ALA236D, ALA65F, ARG224D, ARG233D, ARG238D, ARG58F, ARG61F, ARG64F, ARG71F, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLU52F, ILE62F, LEU230D, LEU235D, LEU54F, LEU66F, LEU68F, LYS223D, LYS231D, LYS234D, LYS241D, LYS63F, MET70F, PHE60F, PRO239D, PRO240D, SER228D, SER232D, SER69F, TRP227D, TYR237D, TYR55F, VAL229D, VAL59F
• D-G: ALA221D, ALA236D, ALA25G, ARG11G, ARG224D, ARG233D, ARG238D, ARG24G, ARG40G, ARG71G, ASP2D, GLN23G, GLU22G, GLU4D, GLU67G, GLY33G, HIS12G, HIS225D, HIS28G, HIS6D, ILE14G, LEU18G, LEU216D, LEU218D, LEU230D, LEU235D, LEU3D, LYS223D, LYS226D, LYS231D, LYS234D, LYS241D, LYS70G, LYS72G, MET222D, PHE21G, PHE26G, PHE66G, PRO20G, PRO217D, PRO239D, PRO240D, PRO27G, SER17G, SER19G, SER1D, SER228D, SER232D, THR15G, TRP227D, TYR16G, TYR220D, TYR237D, TYR29G, VAL10G, VAL13G, VAL219D, VAL229D
• D-H: ALA177D, ALA183D, ALA64H, ALA70H, ARG15D, ARG21H, ARG28D, ARG43H, ARG65H, ASN150D, ASN75H, ASP125D, ASP15H, ASP173D, ASP185D, ASP22D, ASP2D, ASP41H, ASP53H, ASP60H, ASP66H, CYS135D, CYS187D, CYS40H, CYS54H, CYS68H, GLN156D, GLN181D, GLU124D, GLU136D, GLU167D, GLU42H, GLU4D, GLU51H, GLU52H, GLU56H, GLU57H, GLY133D, GLY140D, GLY155D, GLY174D, HIS14D, HIS63H, HIS67H, HIS6D, HIS71H, ILE164D, LEU131D, LEU17H, LEU37H, LEU3D, LEU58H, LEU59H, LEU5D, LEU62H, LEU73H, LEU77H, LYS184D, LYS72H, LYS78H, MET179D, PHE128D, PHE149D, PHE153D, PHE171D, PHE61H, PHE74H, PRO11D, PRO137D, PRO138D, PRO151D, PRO16H, PRO176D, PRO7D, PRO8D, SER129D, SER13D, SER142D, SER180D, SER1D, SER25D, SER45H, SER76H, SER9D, THR132D, THR139D, THR175D, THR178D, THR188D, THR18H, THR24D, THR50H, THR55H, TRP12D, TYR10D, TYR134D, TYR152D, TYR165D, VAL141D, VAL182D, VAL20H, VAL44H, VAL69H
• D-J: ALA39J, ALA41J, ARG201D, ARG203D, ARG27D, ARG28D, ASN47J, ASN61J, ASP172D, ASP173D, ASP199D, ASP22D, ASP36J, ASP40J, ASP59D, CYS55D, GLN31D, GLN37J, GLU32J, GLU44J, GLU48J, GLU58D, GLU60D, GLU60J, GLY16D, GLY205D, GLY213D, GLY38J, GLY49J, GLY53D, HIS14D, HIS198D, HIS200D, HIS23D, HIS54J, HIS57J, ILE26D, ILE42J, ILE46J, LEU17D, LEU18D, LEU206D, LEU209D, LEU210D, LEU214D, LEU215D, LEU21D, LEU51D, LEU51J, LYS202D, LYS207D, LYS50J, LYS53J, LYS56J, LYS58J, MET204D, MET208D, MET211D, MET212D, MET222D, PHE20J, PHE31J, PHE35J, SER13D, SER19D, SER20D, SER25D, THR24D, THR57D, TRP52J, TYR43J, TYR56D, TYR59J, VAL52D, VAL54D
• F-G: ALA23F, ALA24F, ALA43G, ARG11G, ARG2G, ARG39G, ARG40G, ARG47G, ARG61F, ARG64F, ARG71F, ARG9G, ASN22F, ASN36G, ASN53F, ASP56F, ASP57F, ASP67F, GLN72F, GLN73F, GLU52F, GLY25F, HIS12G, ILE14G, ILE47F, ILE62F, ILE74F, LEU29F, LEU46G, LEU68F, LEU75F, LYS28F, LYS32G, LYS44F, LYS63F, MET70F, PHE60F, PRO35G, SER69F, THR15G, THR8G, TRP19F, TRP80F, TYR20F, TYR55F, VAL10G, VAL13G, VAL37G, VAL59F
• G-H: ALA75G, ARG36H, ARG43H, ARG47H, ARG71G, ASN73G, ASP53H, ASP60H, GLU51H, GLU52H, GLU56H, GLU57H, LEU59H, LYS70G, LYS72G, PRO74G, THR50H
• G-J: PHE21G, TYR10J
• J-K: ALA21J, ALA21K, ALA26K, ALA28J, ALA29K, ALA34J, ALA35K, ARG16J, ARG33J, ASN16K, ASN49K, ASP37K, GLN37J, GLU32J, GLY25K, GLY27J, GLY28K, GLY31K, GLY38J, GLY50K, ILE24J, ILE41K, ILE48K, LEU13J, LEU22J, LEU23K, LEU29J, LEU32K, LEU42K, LYS51K, PHE20J, PHE30J, PHE31J, PHE35J, PHE52K, PRO19K, PRO46K, SER18J, SER22K, THR17J, THR19J, THR20K, THR23J, THR36K, TRP17K, TRP24K, TRP34K, TRP38K, TYR47K, VAL18K, VAL25J, VAL26J, VAL27K, VAL30K, VAL33K, VAL45K