2FX7

crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a 16-residue peptide encompassing the 4e10 epitope on gp41

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: L-P
  • Int. Res.: 18
  • Norm. En. per Res.: -4.0238
• Hub Node: L(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-H	-30.5382	-32.6226	-443.803	-506.9638	192	13	17	17477	3	19	16
L-P	-2.53	-9.0193	-60.8793	-72.4286	18	3	1	2355	1	1	0
H-P	0.0	0.6434	-160.056	-159.4126	50	3	4	6306	0	1	4

Interface residues

• L-H: ALA100H, ALA101H, ALA125H, ALA130L, ALA138H, ALA139H, ALA176H, ALA34L, ALA43L, ALA51L, ALA60H, ALA93H, ARG142L, ARG38H, ARG39L, ARG43H, ARG45L, ARG62H, ARG94H, ASN137L, ASN138L, ASN158L, ASN58H, ASP122L, ASP146H, ASP167L, ASP170L, CYS134L, CYS142H, CYS88L, CYS92H, GLN100L, GLN105H, GLN124L, GLN160L, GLN166L, GLN179H, GLN37L, GLN38L, GLN39H, GLN42L, GLN6H, GLN89L, GLN90L, GLN93L, GLU123L, GLU161L, GLU165L, GLU1L, GLU213L, GLU46H, GLU95H, GLY100H, GLY101L, GLY104H, GLY106H, GLY141H, GLY157L, GLY169H, GLY183H, GLY212L, GLY41L, GLY42H, GLY44H, GLY49H, GLY50H, GLY50L, GLY96H, GLY99H, GLY99L, HIS102H, HIS172H, ILE100H, ILE117L, ILE48L, ILE56H, LEU124H, LEU125L, LEU135L, LEU136L, LEU140H, LEU143H, LEU175L, LEU178H, LEU179L, LEU181L, LEU184H, LEU187H, LEU33L, LEU45H, LEU46L, LEU47L, LEU95L, LYS100H, LYS126L, LYS129H, LYS145H, LYS169L, LYS207L, LYS221H, LYS222H, LYS228H, LYS32L, MET48H, PHE100H, PHE116L, PHE118L, PHE122H, PHE139L, PHE174H, PHE209L, PHE63H, PHE98L, PRO100H, PRO119L, PRO120L, PRO123H, PRO126H, PRO175H, PRO40L, PRO44L, PRO55L, PRO61H, SER114L, SER120H, SER121L, SER127H, SER127L, SER130H, SER131L, SER159L, SER162L, SER168H, SER168L, SER174L, SER176L, SER177L, SER180H, SER182H, SER186H, SER188H, SER189H, SER195H, SER208L, SER35H, SER53L, SER56L, SER94L, SER96L, THR129L, THR137H, THR164L, THR167H, THR172L, THR173H, THR178L, THR180L, THR192H, THR57H, THR97H, THR97L, THR98H, TRP100H, TRP103H, TRP35L, TRP36H, TRP47H, TYR173L, TYR185H, TYR186L, TYR36L, TYR49L, TYR59H, TYR86L, TYR87L, TYR91H, TYR91L, VAL115L, VAL121H, VAL132L, VAL133L, VAL144H, VAL163L, VAL171H, VAL177H, VAL190H, VAL191H, VAL193H, VAL225H, VAL37H, VAL85L, VAL89H
• L-P: ASN30L, ASN671P, ASN677P, ASP674P, GLN89L, GLN90L, GLN93L, GLY29L, GLY92L, ILE675P, LEU95L, LYS32L, PHE673P, SER94L, SER96L, THR97L, TRP672P, TYR91L
• H-P: ALA100H, ALA33H, ALA93H, ARG73H, ARG94H, ASN58H, ASN671P, ASN677P, ASP674P, GLU95H, GLY100H, GLY49H, GLY50H, GLY96H, ILE100H, ILE52H, ILE56H, ILE675P, ILE682P, ILE69H, LEU100H, LEU34H, LEU53H, LEU54H, LEU679P, LYS100H, LYS683P, LYS684P, PHE100H, PHE673P, PRO100H, PRO52H, SER28H, SER30H, SER35H, THR31H, THR55H, THR57H, THR676P, THR97H, THR98H, TRP36H, TRP47H, TRP672P, TRP678P, TRP680P, TYR32H, TYR59H, TYR681P, VAL51H