2FUG

crystal structure of the hydrophilic domain of respiratory complex i from thermus thermophilus

• Total interactions analyzed: 496
• Total true interactions: 87
• Strongest Interaction:
  • Chains: 4-7
  • Int. Res.: 26
  • Norm. En. per Res.: -4.9044
• Hub Node: 3(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
1-2	-122.7906	-135.1412	-703.76	-961.6917	222	48	16	28616	11	77	80
1-3	-48.1409	-43.2972	-346.381	-437.8191	152	29	6	16688	7	43	52
1-4	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
1-7	0.0	2.3449	-20.0695	-17.7246	26	0	1	1204	0	3	17
2-3	-12.2866	59.3731	-142.642	-95.5555	58	14	0	5519	2	16	19
2-7	-33.5669	-54.8805	-151.149	-239.5964	80	21	8	7397	3	27	19
2-M	0.0	2.9153	-0.0719	2.8434	9	0	0	47	0	9	13
3-4	-17.7049	-12.6243	-251.567	-281.8962	84	22	5	10632	2	25	20
3-5	-18.5128	-26.8798	-215.024	-260.4167	103	13	1	9248	2	31	28
3-9	-10.8366	-65.5378	-156.043	-232.4175	61	6	1	6177	4	31	26
3-7	-23.1867	-28.4026	-221.243	-272.8323	96	24	4	9568	9	53	60
3-J	0.0	2.1316	-6.2278	-4.0962	11	0	0	350	0	9	8
3-M	0.0	-4.1856	-2.29	-6.4756	14	0	0	284	0	8	11
3-U	0.0	-0.2323			6
4-5	-182.0399	-56.3104	-664.276	-902.6263	229	93	6	29462	14	93	81
4-6	-97.5996	-46.7697	-269.383	-413.7523	104	30	4	12037	5	17	29
4-9	-32.071	-47.1556	-230.729	-309.9556	97	11	4	9834	2	41	21
4-7	-16.1353	-45.5936	-65.7847	-127.5136	26	4	1	2667	6	10	13
5-6	-19.6274	-7.7841	-65.6746	-93.0862	45	6	1	2895	0	11	1
5-9	-9.1868	-55.7485	-185.046	-249.9813	57	7	6	6638	3	12	12
6-9	-44.9542	-11.2593	-329.22	-385.4335	121	41	14	14389	2	34	41
6-J	0.0	-12.0883	-76.2477	-88.336	47	16	0	4476	0	23	16
9-7	0.0	21.7471	-93.8681	-72.121	62	2	3	4834	0	23	24
9-J	0.0	-5.7129	-0.0643	-5.7772	2	0	0	10	0	4	2
7-M	-2.9084	3.3333	-44.3603	-43.9354	34	0	1	1612	0	10	10
7-N	0.0	5.1069			2
A-B	-108.7904	-135.0128	-704.958	-948.7612	222	45	16	28483	11	78	79
A-C	-50.0234	-45.0337	-345.353	-440.4101	152	29	6	16712	7	43	53
A-D	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
A-H	0.0	2.2623	-19.9688	-17.7065	27	0	1	1206	0	3	17
A-U	-17.7092	-0.8135			5
A-X	0.0	-11.3522			6
A-Y	0.0	-6.0942			2
B-C	-12.1397	61.6125	-151.748	-102.2752	59	15	0	5523	2	16	18
B-H	-32.2267	-54.184	-152.837	-239.2476	80	21	8	7435	3	27	19
C-D	-22.0489	-11.0707	-256.061	-289.1806	85	20	5	10648	2	25	20
C-E	-16.5926	-26.2737	-217.684	-260.5504	102	10	1	9193	2	31	28
C-G	-11.0935	-68.1	-153.09	-232.2834	60	8	1	6192	5	31	26
C-H	-14.976	-29.3635	-214.369	-258.7086	96	22	4	9506	9	53	60
D-E	-165.5028	-51.1179	-654.013	-870.6337	229	91	6	29410	14	93	82
D-F	-103.3354	-48.0117	-279.537	-430.8841	104	38	4	12126	5	17	29
D-G	-36.8472	-78.8822	-229.444	-345.1734	96	12	4	9892	2	41	21
D-H	-15.2625	-45.4354	-65.2145	-125.9124	26	4	1	2659	6	10	13
D-T	0.0	13.7274			5
D-U	-3.9476	-26.1735			5
D-Z	-7.079	2.3641			4
E-F	-20.3692	-7.7035	-64.5022	-92.5749	45	6	1	2904	0	11	1
E-G	-14.4782	-56.767	-182.158	-253.4032	57	5	6	6629	4	12	12
E-T	0.0	-1.9108			2
E-Z	0.0	-8.3343			3
F-G	-47.7309	-12.2247	-327.646	-387.6016	120	41	14	14398	2	34	40
G-H	0.0	21.4829	-95.5827	-74.0998	62	2	3	4870	0	23	24
J-K	-105.6386	-136.0847	-706.353	-948.0763	222	47	16	28559	11	79	78
J-L	-51.1202	-41.4323	-352.899	-445.4514	152	30	6	16699	6	43	53
J-M	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	1
J-Q	0.0	2.347			5
K-L	-16.3764	60.2397	-152.8	-108.9367	59	20	0	5551	2	16	19
K-Q	-34.1956	-55.3129			10
L-M	-17.9313	-10.6427	-255.937	-284.511	84	19	5	10650	2	25	20
L-N	-21.5136	-27.4994			17
L-P	-5.5847	-64.9177			12
L-Q	-22.1212	-27.5184			23
M-N	-163.8136	-51.7426			51
M-O	-79.8133	-48.6462			14
M-P	-33.4441	-49.0823			19
M-Q	-15.7878	-45.6499			9
N-O	-21.4104	-7.7681			8
N-P	-16.879	-55.7456			9
O-P	-47.5771	-11.4576			21
P-Q	0.0	21.4089			11
S-T	-121.9863	-138.1154			52
S-U	-53.4934	-45.4547			30
S-Z	0.0	2.3404			5
T-U	-17.6252	59.6953			10
T-Z	-32.8752	-54.2529			10
U-V	-18.4446	-11.5871			10
U-W	-18.7508	-25.8247			17
U-Y	-11.2833	-79.7742			13
U-Z	-16.0028	-26.7799			23
V-W	-142.2902	-50.1238			50
V-X	-85.6472	-47.4787			14
V-Y	-32.3653	-49.2362			19
V-Z	-16.216	-46.849			9
W-X	-21.9894	-7.8505			8
W-Y	-16.2374	-56.4382			9
X-Y	-46.8874	-12.4886			21
Y-Z	0.0	21.5569			11

Interface residues

• 1-2: ALA1312, ALA1421, ALA1482, ALA162, ALA1771, ALA1791, ALA1871, ALA1971, ALA252, ALA262, ALA2801, ALA2891, ALA3401, ALA642, ALA842, ALA912, ALA932, ARG1041, ARG1351, ARG1391, ARG1401, ARG1441, ARG1472, ARG1492, ARG1531, ARG1751, ARG1961, ARG232, ARG242, ARG2601, ARG322, ARG3341, ARG3461, ARG4331, ARG4381, ASN1372, ASN1901, ASN1981, ASN3431, ASP1091, ASP1382, ASP1431, ASP3391, ASP982, CYS1242, CYS1282, CYS1442, CYS1722, CYS1821, CYS3531, CYS832, CYS882, GLN1202, GLN1352, GLN2531, GLN2881, GLN352, GLN362, GLN812, GLN861, GLU1081, GLU1232, GLU132, GLU1371, GLU1392, GLU1432, GLU1461, GLU1512, GLU1642, GLU1782, GLU1802, GLU1931, GLU212, GLU241, GLU2651, GLU3511, GLU592, GLU942, GLU951, GLU952, GLU971, GLY1262, GLY1361, GLY1732, GLY1761, GLY1781, GLY1941, GLY2131, GLY221, GLY222, GLY251, GLY2561, GLY2621, GLY2811, GLY3271, GLY3541, GLY622, GLY922, GLY991, HIS1292, HIS1721, HIS1741, HIS1742, HIS1752, HIS1772, HIS3501, ILE1061, ILE1321, ILE1342, ILE1811, ILE2541, ILE272, ILE2871, ILE2901, ILE2911, ILE3291, ILE3311, LEU1002, LEU1252, LEU1502, LEU1542, LEU1711, LEU1881, LEU1921, LEU1951, LEU2111, LEU2841, LEU312, LEU3301, LEU3441, LEU4361, LEU862, LEU902, LEU962, LYS1021, LYS1212, LYS1501, LYS172, LYS2141, LYS231, LYS2591, LYS3551, LYS892, MET1891, MET282, MET3371, MET3411, MET612, PHE1011, PHE3471, PHE662, PRO1322, PRO1402, PRO192, PRO1991, PRO202, PRO2571, PRO2611, PRO292, PRO2991, PRO3321, PRO4321, PRO4341, PRO981, SER1001, SER1272, SER1911, SER2551, SER2951, SER3361, SER3521, SER4351, SER652, SER682, SER872, SER961, THR1302, THR142, THR1462, THR3451, THR552, THR582, THR852, TRP2121, TRP271, TRP2791, TRP3421, TRP4371, TRP972, TYR1051, TYR1311, TYR1331, TYR1381, TYR1412, TYR1801, TYR182, TYR2641, TYR3481, TYR672, TYR692, TYR702, TYR881, TYR992, VAL1222, VAL1291, VAL1332, VAL1341, VAL1452, VAL1731, VAL1762, VAL1792, VAL211, VAL2581, VAL2631, VAL3281, VAL3351, VAL3381, VAL4311, VAL532, VAL602, VAL632, VAL822
• 1-3: ALA1033, ALA1053, ALA1771, ALA1791, ALA1971, ALA3491, ALA3641, ALA3721, ALA3891, ALA4031, ALA443, ALA803, ALA813, ALA863, ARG1013, ARG1563, ARG1613, ARG1623, ARG1893, ARG1961, ARG2001, ARG2053, ARG3601, ARG3971, ARG4403, ARG463, ASN1143, ASN1901, ASN1981, ASN3691, ASN3861, ASP2013, ASP3831, ASP4041, CYS1813, CYS1821, CYS1843, CYS343, CYS3531, CYS3561, CYS3591, CYS4001, CYS453, CYS833, GLN1043, GLN3781, GLU1023, GLU1093, GLU1583, GLU1923, GLU1931, GLU1983, GLU2043, GLU3511, GLU3611, GLU3801, GLU3851, GLU3881, GLU3951, GLU4393, GLY1063, GLY1781, GLY1941, GLY2063, GLY2131, GLY3541, GLY3621, GLY3651, GLY3791, GLY3961, GLY433, HIS1153, HIS1833, HIS2083, HIS3501, ILE1811, ILE1823, ILE2033, ILE2113, ILE3741, ILE3941, ILE423, ILE4373, LEU1123, LEU1133, LEU1303, LEU1951, LEU2003, LEU2011, LEU3701, LEU3871, LEU3901, LEU3911, LEU3931, LEU4021, LEU4353, LEU493, LEU793, LYS1853, LYS2021, LYS3551, LYS3731, LYS3821, LYS4383, LYS783, MET1073, MET3671, MET473, PHE1103, PHE1573, PHE1593, PHE2023, PHE2103, PHE333, PHE3471, PHE3661, PHE3711, PHE3991, PRO1991, PRO2031, PRO2041, PRO3581, PRO3921, PRO4011, PRO413, PRO4423, PRO773, SER2091, SER3521, SER3981, SER403, SER823, THR1113, THR1553, THR1603, THR2093, THR3571, THR853, TRP2121, TRP4081, TYR1403, TYR1801, TYR3481, VAL1083, VAL1533, VAL1883, VAL2073, VAL3631, VAL3681, VAL503, VAL843, VAL993
• 1-4: MET3214, PHE3661
• 1-7: ALA3721, ARG3461, ARG817, ASN3691, ASP3831, GLN3781, GLU3801, GLY3751, GLY3771, GLY3791, HIS3501, HIS907, HIS927, HIS947, HIS967, ILE3741, LEU3701, LEU797, LYS3731, LYS4281, LYS787, LYS807, PHE3711, THR3761, TRP3421, VAL3681
• 2-3: ALA502, ALA642, ARG2053, ARG242, ARG422, ARG4403, ARG452, ASP1973, ASP2013, ASP2153, GLN1202, GLU1232, GLU1923, GLU1983, GLU2043, GLU212, GLU442, GLU472, GLU482, GLU592, GLY1963, GLY2063, GLY2123, GLY542, GLY622, ILE2033, ILE2113, ILE272, ILE462, LEU2003, LEU2183, LYS4603, MET2143, MET612, PHE1913, PHE2023, PHE2103, PHE2163, PHE662, PHE722, PRO2193, PRO432, PRO4423, PRO572, SER652, SER682, THR2093, THR2133, THR552, THR562, THR582, TYR672, TYR692, VAL1222, VAL1883, VAL1993, VAL602, VAL632
• 2-7: ALA1177, ALA1197, ALA1227, ALA1257, ALA1277, ALA642, ALA897, ARG1147, ARG1217, ARG1237, ARG422, ARG887, ASP1207, ASP982, GLN1202, GLN352, GLN712, GLU1022, GLU1102, GLU1247, GLU442, GLU472, GLU657, GLU952, GLY1052, GLY1067, GLY1072, GLY1092, GLY1152, GLY622, GLY762, HIS792, HIS907, HIS927, HIS947, ILE1062, ILE1087, ILE412, ILE462, ILE917, LEU1002, LEU1042, LEU1107, LEU1187, LEU1267, LEU867, LEU937, LYS1077, MET612, PHE1157, PHE1172, PHE1287, PHE662, PHE677, PHE722, PRO1082, PRO1097, PRO1132, PRO432, PRO572, PRO742, PRO877, SER1182, SER652, SER682, THR1012, THR1032, THR1057, THR1122, THR582, THR752, TRP402, TRP972, TYR672, TYR692, TYR702, TYR992, VAL1112, VAL1192, VAL732
• 2-M: ARG422, ASP202M, ASP62, GLU442, LYS288M, LYS291M, TRP402, TYR257M, VAL264M
• 3-4: ALA1053, ALA1273, ALA3234, ARG1333, ARG1563, ARG1613, ARG2453, ARG93, ASN1143, ASN2463, ASN3064, ASP1183, ASP1323, ASP3044, CYS1193, CYS1223, CYS1283, GLN1313, GLN3084, GLU1093, GLU1293, GLU1363, GLU1413, GLU1583, GLU3184, GLU3224, GLU3334, GLY1063, GLY1253, GLY1263, GLY1383, GLY3344, HIS1153, HIS3154, HIS3274, HIS3304, HIS3364, ILE3094, ILE3254, LEU1123, LEU1133, LEU1173, LEU1303, LEU1393, LEU1513, LEU3164, LEU3174, LYS1243, LYS3294, LYS3394, MET3214, PHE1103, PHE1573, PHE1593, PHE3284, PHE333, PHE3354, PRO1163, PRO1203, PRO1523, PRO3014, PRO3054, PRO3074, PRO3114, PRO3124, PRO3134, SER3204, THR1113, THR1213, THR1343, THR1553, THR3104, THR3194, THR3324, TRP2473, TYR1373, TYR1403, TYR1543, TYR3264, VAL1083, VAL1353, VAL1533, VAL2323, VAL3244
• 3-5: ALA1273, ALA1685, ALA1725, ALA1735, ALA2443, ALA2793, ARG1013, ARG1333, ARG1635, ARG1715, ARG1863, ARG1895, ARG2453, ARG2703, ARG2763, ARG2783, ARG93, ASN2463, ASN4273, ASP1323, ASP2283, ASP293, ASP625, ASP983, CYS1283, CYS2303, CYS483, GLN1043, GLN1313, GLU1293, GLU1363, GLU1413, GLU1615, GLU1695, GLU2483, GLU2503, GLU2513, GLU2733, GLU2813, GLU363, GLU6303, GLY1253, GLY1263, GLY1383, GLY1625, GLY1805, GLY1865, GLY1875, GLY1915, GLY2723, GLY273, GLY4293, HIS4283, ILE1655, ILE1665, ILE2293, ILE2883, ILE6293, LEU1303, LEU1393, LEU1745, LEU1815, LEU1955, LEU323, LYS1243, LYS1423, LYS1855, LYS1905, LYS373, MET203, MET2493, MET473, PHE1595, PHE1705, PHE1835, PHE243, PHE333, PHE4323, PRO1795, PRO2313, PRO2533, PRO313, PRO6283, SER1885, SER1945, SER2713, SER353, THR1343, THR1825, THR2523, THR2693, THR4303, TRP1965, TRP2473, TYR1373, TYR1403, TYR1645, TYR1845, TYR1925, TYR283, VAL1353, VAL233, VAL303
• 3-9: ALA1079, ALA2443, ALA609, ALA619, ALA629, ALA739, ARG1783, ARG1803, ARG2413, ARG2433, ARG2453, ARG2703, ARG869, ASN2463, ASN759, ASP1183, ASP1233, CYS1089, CYS1193, CYS1223, CYS569, CYS599, GLU2483, GLU2733, GLU719, GLU749, GLU859, GLU929, GLY1253, GLY2723, GLY559, GLY849, HIS1673, ILE549, ILE689, LEU1173, LEU1763, LEU2363, LEU2383, LEU2753, LEU589, LYS1243, LYS1663, LYS7073, LYS899, MET2493, PHE2423, PRO1099, PRO1203, PRO1693, PRO729, PRO779, SER2713, SER579, THR1109, THR1213, TRP2473, TYR699, TYR879, VAL709, VAL909
• 3-7: ALA1297, ALA357, ALA577, ALA707, ALA777, ALA897, ARG1613, ARG1623, ARG1783, ARG1803, ARG2053, ARG2453, ARG307, ARG817, ARG857, ARG887, ASP1183, ASP1653, ASP1773, ASP2153, ASP367, ASP397, ASP617, ASP717, CYS1193, CYS1223, GLU1583, GLU1793, GLU2043, GLU327, GLU347, GLU657, GLY2063, GLY2123, GLY2173, GLY627, GLY647, GLY837, HIS1153, HIS1633, HIS1673, HIS1683, HIS2083, HIS767, HIS907, HIS927, HIS947, ILE2033, ILE2113, ILE417, ILE827, ILE917, LEU1173, LEU1267, LEU1703, LEU597, LEU637, LEU687, LEU697, LEU797, LEU867, LYS1663, LYS337, LYS787, LYS807, MET2143, MET557, PHE1287, PHE1573, PHE1593, PHE2103, PHE2163, PHE377, PHE407, PHE677, PRO1163, PRO1203, PRO1693, PRO1723, PRO387, PRO667, PRO747, PRO877, SER587, SER607, SER737, THR1213, THR1603, THR2093, THR2133, THR567, TYR107, TYR427, VAL1643, VAL2073, VAL727
• 3-J: ARG3163, ARG426J, ARG429J, GLN378J, GLU3193, GLU427J, GLY377J, LYS428J, PRO430J, THR376J, VAL3183
• 3-M: ALA7273, ALA7323, ARG7463, GLN7333, GLU184M, GLU185M, GLU298M, GLU7303, GLY7313, LYS191M, PRO188M, PRO299M, PRO7293, VAL187M
• 3-U: ARG651U, GLU4853, GLU4953, GLU4983, GLU646U, LYS330U
• 4-5: ALA1004, ALA1074, ALA1685, ALA1725, ALA1735, ALA2294, ALA2414, ALA3724, ALA505, ALA695, ARG1165, ARG1335, ARG1475, ARG1715, ARG1895, ARG1935, ARG2404, ARG2494, ARG3674, ARG3714, ARG4094, ARG645, ARG675, ARG734, ARG875, ARG915, ASN1125, ASN205, ASN245, ASN2454, ASN3064, ASN3774, ASN475, ASP1205, ASP1405, ASP1495, ASP1785, ASP2474, ASP3044, ASP3604, ASP4084, ASP515, ASP565, ASP625, ASP845, GLN3084, GLN3794, GLN774, GLU1024, GLU1155, GLU1175, GLU1395, GLU1545, GLU185, GLU2274, GLU3334, GLU3414, GLU3524, GLU45, GLU674, GLU714, GLU735, GLY1064, GLY1535, GLY1765, GLY1805, GLY1865, GLY1875, GLY1915, GLY215, GLY2334, GLY235, GLY2364, GLY2374, GLY2434, GLY3344, GLY3404, GLY3544, GLY3614, GLY3624, GLY455, GLY545, GLY604, GLY654, GLY795, GLY835, GLY855, HIS1445, HIS3364, HIS584, HIS634, HIS724, ILE1245, ILE2244, ILE2304, ILE3094, ILE3574, ILE525, ILE594, LEU1044, LEU1054, LEU1145, LEU1215, LEU1365, LEU1415, LEU1465, LEU1525, LEU1745, LEU1815, LEU1955, LEU225, LEU2344, LEU2394, LEU3534, LEU3784, LEU3814, LEU434, LEU495, LEU555, LEU585, LEU624, LEU745, LEU775, LEU994, LYS1034, LYS1345, LYS1485, LYS1775, LYS1855, LYS1905, LYS3294, LYS3394, LYS3694, LYS684, LYS815, MET15, MET3644, MET704, PHE1135, PHE1705, PHE3284, PHE3354, PHE3754, PHE465, PHE485, PHE664, PHE885, PHE895, PRO1385, PRO1455, PRO1515, PRO1675, PRO2254, PRO2264, PRO3074, PRO3374, PRO3384, PRO3454, PRO3654, PRO3734, PRO3824, PRO574, PRO615, PRO635, PRO785, SER1885, SER1945, SER2384, SER2424, SER3594, SER3634, SER3744, SER3804, SER765, SER865, THR1055, THR1375, THR1575, THR1755, THR1825, THR2354, THR3104, THR3324, THR3464, THR595, THR644, THR694, THR744, TRP1965, TRP265, TRP805, TYR1195, TYR1505, TYR1925, TYR3264, TYR3314, TYR3434, TYR3554, TYR3564, TYR3664, TYR3834, TYR575, TYR605, TYR614, TYR725, TYR754, TYR814, TYR935, VAL1014, VAL1084, VAL1185, VAL1255, VAL2234, VAL2444, VAL2484, VAL3424, VAL3444, VAL3584, VAL3684, VAL3704, VAL3764, VAL4074, VAL454, VAL535, VAL554, VAL564, VAL715, VAL755, VAL905
• 4-6: ALA1106, ALA1226, ALA446, ALA476, ALA526, ALA566, ALA816, ALA896, ARG1436, ARG1534, ARG1674, ARG4094, ARG424, ARG734, ARG836, ARG844, ARG946, ASN1196, ASN1206, ASP1584, ASP4064, ASP4084, ASP556, ASP864, CYS1116, CYS1406, CYS456, CYS466, GLN1664, GLN774, GLU1456, GLU1544, GLU1614, GLU496, GLU674, GLY1156, GLY1166, GLY1396, GLY1654, GLY4054, GLY426, GLY604, GLY654, GLY826, HIS1694, HIS1704, HIS384, HIS584, HIS634, HIS724, ILE1236, ILE486, ILE594, LEU1384, LEU1574, LEU414, LEU434, LEU436, LEU624, LEU846, LEU884, LYS684, LYS866, LYS876, MET1176, MET4044, MET444, MET506, MET516, MET704, MET854, MET886, MET926, PHE1186, PHE1464, PHE1474, PHE1504, PHE1684, PHE416, PHE664, PRO1416, PRO1426, PRO1446, PRO574, PRO834, PRO906, SER856, SER904, THR1354, THR406, THR546, THR644, THR694, THR804, THR824, TYR1216, TYR614, TYR814, TYR874, VAL1246, VAL1314, VAL4034, VAL404, VAL916
• 4-9: ALA1079, ALA329, ALA609, ALA619, ALA629, ALA659, ARG1674, ARG1679, ARG1744, ARG3034, ARG3144, ARG369, ARG734, ARG844, ARG869, ARG979, ASN1714, ASN784, ASP1584, ASP1814, CYS1019, CYS1049, CYS1089, CYS569, CYS599, CYS639, CYS989, GLN1664, GLN774, GLU1059, GLU1069, GLU1614, GLU1699, GLU1804, GLU1844, GLU1854, GLU1894, GLU3334, GLY1029, GLY1119, GLY1654, GLY399, HIS1694, HIS1704, HIS3274, HIS3304, HIS389, HIS724, ILE794, ILE999, LEU1039, LEU1159, LEU1574, LEU1594, LEU1824, LEU3174, LEU339, LEU589, LEU764, LYS1794, LYS3294, LYS349, LYS529, MET3644, PHE1009, PHE1604, PHE1684, PHE1864, PHE3284, PHE379, PRO1099, PRO1649, PRO1689, PRO1834, PRO3114, PRO359, PRO649, PRO834, SER579, THR1109, THR1644, THR3324, THR694, THR744, THR804, TRP1624, TYR1179, TYR1659, TYR1724, TYR3314, TYR669, TYR814, VAL1149, VAL1634, VAL1784, VAL319, VAL3244
• 4-7: ALA777, ARG3144, ARG437, ARG467, ARG757, ASP397, GLU3184, GLU457, HIS3154, HIS3274, HIS767, ILE417, LEU3164, LEU3174, MET447, PHE377, PHE407, PRO3134, PRO387, PRO477, PRO747, SER3204, THR3194, TYR427, TYR487, VAL3244
• 5-6: ALA1226, ALA1685, ALA896, ARG1605, ARG1715, ASN1196, ASN1206, ASN1266, ASP1405, GLN1256, GLU1395, GLU1425, GLU1545, GLU1656, GLY1156, GLY1166, GLY1535, HIS1445, ILE1236, ILE1245, ILE1655, ILE1665, LEU1365, LEU1415, LEU1465, LEU1525, LEU1585, LYS866, LYS876, MET1176, MET886, PHE1186, PRO1385, PRO1455, PRO1515, PRO1565, PRO1675, PRO906, SER1146, SER856, THR1375, THR1555, THR1575, TYR1216, TYR1505
• 5-9: ALA1685, ALA1725, ALA1735, ALA609, ALA619, ALA629, ALA659, ALA679, ARG1479, ARG1605, ARG1635, ARG1715, ARG979, ASN949, ASP1289, ASP1359, CYS599, CYS639, GLU1349, GLU1545, GLU1615, GLU719, GLU929, GLY1329, GLY1625, ILE1655, ILE1665, ILE689, ILE939, LEU1299, LEU1525, LEU1585, LEU589, LEU969, LYS1339, LYS1449, LYS899, MET1369, MET959, PHE1595, PHE1705, PRO1565, PRO1675, PRO649, SER1279, SER579, THR1555, THR1575, TYR1269, TYR1319, TYR1645, TYR669, TYR699, TYR919, VAL1309, VAL709, VAL909
• 6-9: ALA1106, ALA1126, ALA1229, ALA1466, ALA1506, ALA1509, ALA1626, ALA299, ALA329, ALA659, ALA679, ARG1436, ARG1479, ARG1489, ARG1529, ARG1596, ARG1666, ARG1696, ARG409, ARG836, ARG979, ASN1196, ASN1206, ASN1266, ASN1646, ASN949, ASP1189, ASP1239, ASP1286, ASP1289, ASP1346, ASP1359, ASP289, ASP556, CYS1019, CYS1116, CYS1406, CYS639, CYS989, GLN1256, GLN1469, GLN1536, GLN1556, GLN1616, GLU1209, GLU1259, GLU1456, GLU1499, GLU1656, GLU1686, GLY1096, GLY1156, GLY1166, GLY1396, GLY1606, GLY1609, GLY1676, GLY399, HIS389, HIS419, ILE1066, ILE1236, ILE1486, ILE999, LEU1299, LEU1476, LEU1546, LEU1706, LEU339, LEU969, LYS1449, LYS1519, LYS1566, LYS1576, LYS1589, LYS349, MET1086, MET1176, MET1219, MET1526, MET959, PHE1009, PHE1186, PHE1199, PHE379, PRO1386, PRO1416, PRO1426, PRO1446, PRO1459, PRO1716, PRO279, PRO309, PRO649, SER1076, SER1136, SER1146, SER1279, SER1296, THR1439, THR1539, TYR1179, TYR1249, TYR1269, TYR1319, TYR1366, TYR1496, TYR1619, TYR1636, TYR269, TYR669, VAL1246, VAL1309, VAL1336, VAL1356, VAL1376, VAL1516, VAL1579, VAL1586, VAL1599, VAL319
• 6-J: ALA280J, ARG12J, ARG166, ARG1696, ARG260J, ARG273J, ASP10J, ASP308J, GLU156, GLU176, GLU256, GLU274J, GLU278J, GLU304J, GLU305J, GLY186, GLY269J, GLY281J, GLY282J, ILE196, ILE276J, LEU206, LEU266J, LEU275J, LEU284J, LEU307J, LYS259J, LYS266, LYS319J, MET311J, PHE216, PHE272J, PHE302J, PRO11J, PRO283J, PRO310J, THR226, THR236, THR270J, THR271J, THR303J, THR309J, TRP279J, TYR1636, TYR277J, VAL258J, VAL306J
• 9-7: ALA1079, ALA1129, ALA357, ALA839, ARG1679, ARG217, ARG307, ARG437, ARG459, ARG467, ARG869, ASN489, ASN759, ASP367, ASP497, ASP769, CYS1089, CYS539, CYS569, GLU1059, GLU1069, GLU1699, GLU1719, GLU327, GLU347, GLU457, GLU519, GLU789, GLU859, GLY1119, GLY499, GLY849, HIS469, ILE417, ILE547, ILE549, LEU1709, LEU507, LEU509, LEU589, LYS337, LYS529, MET447, PHE317, PHE377, PHE407, PRO1099, PRO1689, PRO387, PRO477, PRO479, PRO517, PRO779, PRO809, SER829, THR1109, THR449, THR527, THR537, TYR427, TYR487, VAL1149
• 9-J: ARG1529, GLU305J
• 7-M: ALA1227, ALA1257, ALA1277, ALA1297, ALA247, ALA267, ARG1217, ARG1237, ARG296M, ASP1207, ASP247M, ASP263M, ASP617, GLN257, GLN292M, GLU1247, GLU227, GLU295M, GLY256M, GLY287, GLY627, LEU1267, LYS250M, LYS277, PHE1287, PHE677, PRO265M, SER255M, TYR237, TYR254M, TYR257M, VAL248M, VAL264M, VAL297
• 7-N: ASP84N, GLU1137
• A-B: ALA131B, ALA142A, ALA148B, ALA16B, ALA177A, ALA179A, ALA187A, ALA197A, ALA25B, ALA26B, ALA280A, ALA289A, ALA340A, ALA64B, ALA84B, ALA91B, ALA93B, ARG104A, ARG135A, ARG139A, ARG140A, ARG144A, ARG147B, ARG149B, ARG153A, ARG175A, ARG196A, ARG23B, ARG24B, ARG260A, ARG32B, ARG334A, ARG346A, ARG433A, ARG438A, ASN137B, ASN190A, ASN198A, ASN343A, ASP109A, ASP138B, ASP143A, ASP170A, ASP339A, ASP98B, CYS124B, CYS128B, CYS144B, CYS182A, CYS353A, CYS83B, CYS88B, GLN120B, GLN135B, GLN253A, GLN288A, GLN35B, GLN36B, GLN81B, GLN86A, GLU108A, GLU123B, GLU137A, GLU139B, GLU13B, GLU143B, GLU146A, GLU151B, GLU164B, GLU178B, GLU180B, GLU193A, GLU21B, GLU24A, GLU265A, GLU351A, GLU59B, GLU94B, GLU95A, GLU95B, GLU97A, GLY126B, GLY136A, GLY173B, GLY176A, GLY178A, GLY194A, GLY213A, GLY22A, GLY22B, GLY256A, GLY25A, GLY262A, GLY281A, GLY327A, GLY354A, GLY62B, GLY92B, GLY99A, HIS129B, HIS172A, HIS174A, HIS174B, HIS175B, HIS177B, HIS350A, ILE106A, ILE132A, ILE134B, ILE181A, ILE254A, ILE27B, ILE287A, ILE290A, ILE291A, ILE329A, ILE331A, LEU100B, LEU125B, LEU150B, LEU154B, LEU171A, LEU188A, LEU192A, LEU195A, LEU211A, LEU284A, LEU30B, LEU31B, LEU330A, LEU344A, LEU436A, LEU86B, LEU90B, LEU96B, LYS102A, LYS121B, LYS150A, LYS17B, LYS214A, LYS23A, LYS259A, LYS89B, MET189A, MET28B, MET337A, MET341A, MET61B, PHE101A, PHE347A, PHE66B, PRO132B, PRO140B, PRO199A, PRO19B, PRO20B, PRO257A, PRO261A, PRO299A, PRO29B, PRO332A, PRO432A, PRO434A, PRO98A, SER100A, SER127B, SER191A, SER255A, SER295A, SER336A, SER352A, SER435A, SER65B, SER68B, SER87B, SER96A, THR130B, THR146B, THR14B, THR345A, THR55B, THR58B, THR85B, TRP212A, TRP279A, TRP27A, TRP342A, TRP437A, TRP97B, TYR105A, TYR131A, TYR133A, TYR138A, TYR141B, TYR180A, TYR18B, TYR264A, TYR348A, TYR67B, TYR69B, TYR70B, TYR88A, TYR99B, VAL122B, VAL129A, VAL133B, VAL134A, VAL145B, VAL173A, VAL176B, VAL179B, VAL21A, VAL258A, VAL263A, VAL328A, VAL335A, VAL338A, VAL431A, VAL53B, VAL60B, VAL63B, VAL82B
• A-C: ALA103C, ALA105C, ALA177A, ALA179A, ALA197A, ALA349A, ALA364A, ALA372A, ALA389A, ALA403A, ALA44C, ALA80C, ALA81C, ALA86C, ARG101C, ARG156C, ARG161C, ARG162C, ARG189C, ARG196A, ARG200A, ARG205C, ARG360A, ARG397A, ARG440C, ARG46C, ASN114C, ASN190A, ASN198A, ASN369A, ASN386A, ASP201C, ASP383A, ASP404A, CYS181C, CYS182A, CYS184C, CYS34C, CYS353A, CYS356A, CYS359A, CYS400A, CYS45C, CYS83C, GLN104C, GLN378A, GLU102C, GLU109C, GLU158C, GLU192C, GLU193A, GLU198C, GLU204C, GLU351A, GLU361A, GLU380A, GLU385A, GLU388A, GLU395A, GLU439C, GLY106C, GLY178A, GLY194A, GLY206C, GLY213A, GLY354A, GLY362A, GLY365A, GLY379A, GLY396A, GLY43C, HIS115C, HIS183C, HIS208C, HIS350A, ILE181A, ILE182C, ILE203C, ILE211C, ILE374A, ILE394A, ILE42C, ILE437C, LEU112C, LEU113C, LEU130C, LEU195A, LEU200C, LEU201A, LEU370A, LEU387A, LEU390A, LEU391A, LEU393A, LEU402A, LEU435C, LEU49C, LEU79C, LYS185C, LYS202A, LYS355A, LYS373A, LYS382A, LYS438C, LYS78C, MET107C, MET367A, MET47C, PHE110C, PHE157C, PHE159C, PHE202C, PHE210C, PHE33C, PHE347A, PHE366A, PHE371A, PHE399A, PRO199A, PRO203A, PRO204A, PRO358A, PRO392A, PRO401A, PRO41C, PRO442C, PRO77C, SER209A, SER352A, SER398A, SER40C, SER82C, THR111C, THR155C, THR160C, THR209C, THR357A, THR85C, TRP212A, TRP408A, TYR140C, TYR180A, TYR348A, VAL108C, VAL153C, VAL188C, VAL207C, VAL363A, VAL368A, VAL50C, VAL84C, VAL99C
• A-D: MET321D, PHE366A
• A-H: ALA372A, ARG346A, ARG81H, ASN369A, ASP383A, GLN378A, GLU380A, GLY375A, GLY377A, GLY379A, HIS350A, HIS90H, HIS92H, HIS94H, HIS96H, ILE374A, LEU370A, LEU79H, LYS373A, LYS428A, LYS78H, LYS80H, PHE371A, SER5H, THR376A, TRP342A, VAL368A
• A-U: ARG316U, ARG429A, GLU314U, GLU427A, LYS428A
• A-X: ARG169X, ARG273A, ASP308A, GLU17X, GLU304A, GLU305A
• A-Y: ARG152Y, GLU305A
• B-C: ALA50B, ALA64B, ARG205C, ARG24B, ARG42B, ARG440C, ARG45B, ASP197C, ASP201C, ASP215C, GLN120B, GLU123B, GLU192C, GLU198C, GLU204C, GLU21B, GLU44B, GLU47B, GLU48B, GLU59B, GLY196C, GLY206C, GLY212C, GLY54B, GLY62B, ILE203C, ILE211C, ILE27B, ILE41B, ILE46B, LEU200C, LEU218C, LYS460C, MET214C, MET61B, PHE191C, PHE202C, PHE210C, PHE216C, PHE66B, PHE72B, PRO219C, PRO43B, PRO442C, PRO57B, SER65B, SER68B, THR209C, THR213C, THR55B, THR56B, THR58B, TYR67B, TYR69B, VAL122B, VAL188C, VAL199C, VAL60B, VAL63B
• B-H: ALA117H, ALA119H, ALA122H, ALA125H, ALA127H, ALA64B, ALA89H, ARG114H, ARG121H, ARG123H, ARG42B, ARG88H, ASP120H, ASP98B, GLN120B, GLN35B, GLN71B, GLU102B, GLU110B, GLU124H, GLU44B, GLU47B, GLU65H, GLU95B, GLY105B, GLY106H, GLY107B, GLY109B, GLY115B, GLY62B, GLY76B, HIS79B, HIS90H, HIS92H, HIS94H, ILE106B, ILE108H, ILE41B, ILE46B, ILE91H, LEU100B, LEU104B, LEU110H, LEU118H, LEU126H, LEU86H, LEU93H, LYS107H, MET61B, PHE115H, PHE117B, PHE128H, PHE66B, PHE67H, PHE72B, PRO108B, PRO109H, PRO113B, PRO43B, PRO57B, PRO74B, PRO87H, SER118B, SER65B, SER68B, THR101B, THR103B, THR105H, THR112B, THR58B, THR75B, TRP40B, TRP97B, TYR67B, TYR69B, TYR70B, TYR99B, VAL111B, VAL119B, VAL73B
• C-D: ALA105C, ALA127C, ALA323D, ARG133C, ARG156C, ARG161C, ARG245C, ARG9C, ASN114C, ASN246C, ASN306D, ASP118C, ASP123C, ASP132C, ASP304D, CYS119C, CYS122C, CYS128C, GLN131C, GLN308D, GLU109C, GLU129C, GLU136C, GLU141C, GLU158C, GLU318D, GLU322D, GLU333D, GLY106C, GLY125C, GLY126C, GLY138C, GLY334D, HIS115C, HIS315D, HIS327D, HIS330D, HIS336D, ILE309D, ILE325D, LEU112C, LEU113C, LEU117C, LEU130C, LEU139C, LEU151C, LEU316D, LEU317D, LYS124C, LYS329D, LYS339D, MET321D, PHE110C, PHE157C, PHE159C, PHE328D, PHE335D, PHE33C, PRO116C, PRO120C, PRO152C, PRO301D, PRO305D, PRO307D, PRO311D, PRO312D, PRO313D, SER320D, THR111C, THR121C, THR134C, THR155C, THR310D, THR319D, THR332D, TRP247C, TYR137C, TYR140C, TYR154C, TYR326D, VAL108C, VAL135C, VAL153C, VAL232C, VAL324D
• C-E: ALA127C, ALA168E, ALA172E, ALA173E, ALA244C, ALA279C, ARG101C, ARG133C, ARG163E, ARG171E, ARG186C, ARG189E, ARG245C, ARG270C, ARG276C, ARG278C, ARG9C, ASN246C, ASN427C, ASP132C, ASP228C, ASP29C, ASP62E, ASP98C, CYS128C, CYS230C, CYS48C, GLN104C, GLN131C, GLU129C, GLU136C, GLU141C, GLU161E, GLU169E, GLU248C, GLU250C, GLU251C, GLU273C, GLU281C, GLU36C, GLU630C, GLY125C, GLY126C, GLY138C, GLY162E, GLY180E, GLY186E, GLY187E, GLY191E, GLY272C, GLY27C, GLY429C, HIS428C, ILE165E, ILE166E, ILE229C, ILE288C, ILE629C, LEU130C, LEU139C, LEU174E, LEU181E, LEU195E, LEU32C, LYS124C, LYS142C, LYS185E, LYS190E, LYS37C, MET20C, MET249C, PHE159E, PHE170E, PHE183E, PHE24C, PHE33C, PHE432C, PRO179E, PRO231C, PRO253C, PRO31C, PRO628C, SER188E, SER194E, SER271C, SER35C, THR134C, THR182E, THR252C, THR269C, THR430C, TRP196E, TRP247C, TYR137C, TYR140C, TYR164E, TYR184E, TYR192E, TYR28C, VAL135C, VAL23C, VAL30C
• C-G: ALA107G, ALA244C, ALA60G, ALA61G, ALA62G, ALA73G, ARG178C, ARG180C, ARG241C, ARG243C, ARG245C, ARG270C, ARG86G, ASN246C, ASN75G, ASP118C, ASP123C, CYS108G, CYS119C, CYS122C, CYS56G, CYS59G, GLU248C, GLU273C, GLU71G, GLU74G, GLU85G, GLU92G, GLY125C, GLY272C, GLY55G, GLY84G, HIS167C, ILE54G, ILE68G, LEU176C, LEU236C, LEU238C, LEU275C, LEU58G, LYS124C, LYS166C, LYS707C, LYS89G, MET249C, PHE242C, PRO109G, PRO120C, PRO169C, PRO72G, PRO77G, SER271C, SER57G, THR110G, THR121C, TRP247C, TYR69G, TYR87G, VAL70G, VAL90G
• C-H: ALA129H, ALA35H, ALA57H, ALA70H, ALA77H, ALA89H, ARG161C, ARG162C, ARG178C, ARG180C, ARG205C, ARG245C, ARG30H, ARG81H, ARG85H, ARG88H, ASP118C, ASP165C, ASP177C, ASP215C, ASP36H, ASP39H, ASP61H, ASP71H, CYS119C, CYS122C, GLU158C, GLU179C, GLU204C, GLU32H, GLU34H, GLU65H, GLY206C, GLY212C, GLY217C, GLY62H, GLY64H, GLY83H, HIS115C, HIS163C, HIS167C, HIS168C, HIS208C, HIS76H, HIS90H, HIS92H, HIS94H, ILE203C, ILE211C, ILE41H, ILE82H, ILE91H, LEU117C, LEU126H, LEU170C, LEU59H, LEU63H, LEU68H, LEU69H, LEU79H, LEU86H, LYS166C, LYS33H, LYS78H, LYS80H, MET214C, MET55H, PHE128H, PHE157C, PHE159C, PHE210C, PHE216C, PHE37H, PHE40H, PHE67H, PRO116C, PRO120C, PRO169C, PRO172C, PRO38H, PRO66H, PRO74H, PRO87H, SER58H, SER60H, SER73H, THR121C, THR160C, THR209C, THR213C, THR56H, TYR10H, TYR42H, VAL164C, VAL207C, VAL72H
• D-E: ALA100D, ALA107D, ALA168E, ALA172E, ALA173E, ALA229D, ALA241D, ALA372D, ALA50E, ALA69E, ARG116E, ARG133E, ARG147E, ARG171E, ARG189E, ARG193E, ARG240D, ARG249D, ARG367D, ARG371D, ARG409D, ARG64E, ARG67E, ARG73D, ARG87E, ARG91E, ASN112E, ASN20E, ASN245D, ASN24E, ASN306D, ASN377D, ASN47E, ASP120E, ASP140E, ASP149E, ASP178E, ASP19E, ASP247D, ASP304D, ASP360D, ASP408D, ASP51E, ASP56E, ASP62E, ASP84E, GLN308D, GLN379D, GLN77D, GLU102D, GLU115E, GLU117E, GLU139E, GLU154E, GLU18E, GLU227D, GLU333D, GLU341D, GLU352D, GLU4E, GLU67D, GLU71D, GLU73E, GLY106D, GLY153E, GLY176E, GLY180E, GLY186E, GLY187E, GLY191E, GLY21E, GLY233D, GLY236D, GLY237D, GLY23E, GLY243D, GLY334D, GLY340D, GLY354D, GLY361D, GLY362D, GLY45E, GLY54E, GLY60D, GLY65D, GLY79E, GLY83E, GLY85E, HIS144E, HIS336D, HIS58D, HIS63D, HIS72D, ILE124E, ILE224D, ILE230D, ILE309D, ILE357D, ILE52E, ILE59D, LEU104D, LEU105D, LEU114E, LEU121E, LEU136E, LEU141E, LEU146E, LEU152E, LEU174E, LEU181E, LEU195E, LEU22E, LEU234D, LEU239D, LEU353D, LEU378D, LEU381D, LEU43D, LEU49E, LEU55E, LEU58E, LEU62D, LEU74E, LEU77E, LEU99D, LYS103D, LYS134E, LYS148E, LYS177E, LYS190E, LYS329D, LYS339D, LYS369D, LYS68D, LYS81E, MET1E, MET364D, MET70D, PHE113E, PHE170E, PHE328D, PHE335D, PHE375D, PHE46E, PHE48E, PHE66D, PHE88E, PHE89E, PRO138E, PRO145E, PRO151E, PRO167E, PRO225D, PRO226D, PRO307D, PRO337D, PRO338D, PRO345D, PRO365D, PRO373D, PRO382D, PRO57D, PRO61E, PRO63E, PRO78E, SER188E, SER194E, SER238D, SER242D, SER359D, SER363D, SER374D, SER380D, SER76E, SER86E, THR105E, THR137E, THR157E, THR175E, THR182E, THR235D, THR310D, THR332D, THR346D, THR59E, THR64D, THR69D, THR74D, TRP196E, TRP26E, TRP80E, TYR119E, TYR150E, TYR192E, TYR326D, TYR331D, TYR343D, TYR355D, TYR356D, TYR366D, TYR383D, TYR57E, TYR60E, TYR61D, TYR72E, TYR75D, TYR81D, TYR93E, VAL101D, VAL108D, VAL118E, VAL125E, VAL223D, VAL244D, VAL248D, VAL342D, VAL344D, VAL358D, VAL368D, VAL370D, VAL376D, VAL407D, VAL45D, VAL53E, VAL55D, VAL56D, VAL71E, VAL75E, VAL90E
• D-F: ALA110F, ALA122F, ALA44F, ALA47F, ALA52F, ALA56F, ALA81F, ALA89F, ARG143F, ARG153D, ARG167D, ARG409D, ARG42D, ARG73D, ARG83F, ARG84D, ARG94F, ASN119F, ASN120F, ASP158D, ASP406D, ASP408D, ASP55F, ASP86D, CYS111F, CYS140F, CYS45F, CYS46F, GLN166D, GLN77D, GLU145F, GLU154D, GLU161D, GLU49F, GLU67D, GLY115F, GLY116F, GLY139F, GLY165D, GLY405D, GLY42F, GLY60D, GLY65D, GLY82F, HIS169D, HIS170D, HIS38D, HIS58D, HIS63D, HIS72D, ILE123F, ILE48F, ILE59D, LEU138D, LEU157D, LEU41D, LEU43D, LEU43F, LEU62D, LEU84F, LEU88D, LYS68D, LYS86F, LYS87F, MET117F, MET404D, MET44D, MET50F, MET51F, MET70D, MET85D, MET88F, MET92F, PHE118F, PHE146D, PHE147D, PHE150D, PHE168D, PHE41F, PHE66D, PRO141F, PRO142F, PRO144F, PRO57D, PRO83D, PRO90F, SER85F, SER90D, THR135D, THR40F, THR54F, THR64D, THR69D, THR80D, THR82D, TYR121F, TYR61D, TYR81D, TYR87D, VAL124F, VAL131D, VAL403D, VAL40D, VAL91F
• D-G: ALA107G, ALA32G, ALA60G, ALA61G, ALA62G, ALA65G, ARG167D, ARG167G, ARG174D, ARG303D, ARG314D, ARG36G, ARG73D, ARG84D, ARG97G, ASN171D, ASN78D, ASP158D, ASP181D, CYS101G, CYS104G, CYS108G, CYS56G, CYS59G, CYS63G, CYS98G, GLN166D, GLN77D, GLU105G, GLU106G, GLU161D, GLU169G, GLU180D, GLU184D, GLU185D, GLU189D, GLU333D, GLY102G, GLY111G, GLY165D, GLY39G, HIS169D, HIS170D, HIS327D, HIS330D, HIS38G, HIS72D, ILE54G, ILE79D, ILE99G, LEU103G, LEU115G, LEU157D, LEU159D, LEU182D, LEU317D, LEU33G, LEU58G, LEU76D, LYS179D, LYS329D, LYS34G, LYS52G, MET364D, PHE100G, PHE160D, PHE168D, PHE186D, PHE328D, PHE37G, PRO109G, PRO164G, PRO168G, PRO183D, PRO311D, PRO35G, PRO64G, PRO83D, SER57G, THR110G, THR164D, THR332D, THR69D, THR74D, THR80D, TRP162D, TYR117G, TYR165G, TYR172D, TYR331D, TYR66G, TYR81D, VAL114G, VAL163D, VAL31G, VAL324D
• D-H: ALA77H, ARG314D, ARG43H, ARG46H, ARG75H, ASP39H, GLU318D, GLU45H, HIS315D, HIS327D, HIS76H, ILE41H, LEU316D, LEU317D, MET44H, PHE37H, PHE40H, PRO313D, PRO38H, PRO47H, PRO74H, SER320D, THR319D, TYR42H, TYR48H, VAL324D
• D-T: ASP202D, ASP5T, ASP6T, GLU44T, LYS288D
• D-U: ARG724U, ARG746U, GLU298D, GLU730U, LYS191D
• D-Z: ALA129Z, LYS250D, LYS27Z, TYR257D
• E-F: ALA122F, ALA168E, ALA89F, ARG160E, ARG171E, ASN119F, ASN120F, ASN126F, ASP140E, GLN125F, GLU139E, GLU142E, GLU154E, GLU165F, GLY115F, GLY116F, GLY153E, HIS144E, ILE123F, ILE124E, ILE165E, ILE166E, LEU136E, LEU141E, LEU146E, LEU152E, LEU158E, LYS86F, LYS87F, MET117F, MET88F, PHE118F, PRO138E, PRO145E, PRO151E, PRO156E, PRO167E, PRO90F, SER114F, SER85F, THR137E, THR155E, THR157E, TYR121F, TYR150E
• E-G: ALA168E, ALA172E, ALA173E, ALA60G, ALA61G, ALA62G, ALA65G, ALA67G, ARG147G, ARG160E, ARG163E, ARG171E, ARG97G, ASN94G, ASP128G, ASP135G, CYS59G, CYS63G, GLU134G, GLU154E, GLU161E, GLU71G, GLU92G, GLY132G, GLY162E, ILE165E, ILE166E, ILE68G, ILE93G, LEU129G, LEU152E, LEU158E, LEU58G, LEU96G, LYS133G, LYS144G, LYS89G, MET136G, MET95G, PHE159E, PHE170E, PRO156E, PRO167E, PRO64G, SER127G, SER57G, THR155E, THR157E, TYR126G, TYR131G, TYR164E, TYR66G, TYR69G, TYR91G, VAL130G, VAL70G, VAL90G
• E-T: ASP114T, LYS81E
• E-Z: ARG2E, ASP84E, GLU113Z
• F-G: ALA110F, ALA112F, ALA122G, ALA146F, ALA150F, ALA150G, ALA162F, ALA29G, ALA32G, ALA65G, ALA67G, ARG143F, ARG147G, ARG148G, ARG152G, ARG159F, ARG166F, ARG169F, ARG40G, ARG83F, ARG97G, ASN119F, ASN120F, ASN126F, ASN164F, ASN94G, ASP123G, ASP128F, ASP128G, ASP134F, ASP135G, ASP28G, ASP55F, CYS101G, CYS111F, CYS140F, CYS63G, CYS98G, GLN125F, GLN146G, GLN153F, GLN155F, GLN161F, GLU120G, GLU125G, GLU145F, GLU149G, GLU165F, GLU168F, GLY109F, GLY115F, GLY116F, GLY139F, GLY160F, GLY160G, GLY167F, GLY39G, HIS38G, HIS41G, ILE106F, ILE123F, ILE148F, ILE99G, LEU129G, LEU147F, LEU154F, LEU170F, LEU33G, LEU96G, LYS144G, LYS151G, LYS156F, LYS157F, LYS158G, LYS34G, MET108F, MET117F, MET121G, MET152F, MET95G, PHE100G, PHE118F, PHE119G, PHE37G, PRO138F, PRO141F, PRO142F, PRO144F, PRO145G, PRO171F, PRO27G, PRO30G, PRO64G, SER107F, SER113F, SER114F, SER127G, SER129F, THR143G, THR153G, TYR117G, TYR124G, TYR126G, TYR131G, TYR136F, TYR149F, TYR161G, TYR163F, TYR26G, TYR66G, VAL124F, VAL130G, VAL133F, VAL135F, VAL137F, VAL151F, VAL157G, VAL158F, VAL159G, VAL31G
• G-H: ALA107G, ALA112G, ALA35H, ALA83G, ARG167G, ARG21H, ARG30H, ARG43H, ARG45G, ARG46H, ARG86G, ASN48G, ASN75G, ASP36H, ASP49H, ASP76G, CYS108G, CYS53G, CYS56G, GLU105G, GLU106G, GLU169G, GLU171G, GLU32H, GLU34H, GLU45H, GLU51G, GLU78G, GLU85G, GLY111G, GLY49G, GLY84G, HIS46G, ILE41H, ILE54G, ILE54H, LEU170G, LEU50G, LEU50H, LEU58G, LYS33H, LYS52G, MET44H, PHE31H, PHE37H, PHE40H, PRO109G, PRO168G, PRO38H, PRO47G, PRO47H, PRO51H, PRO77G, PRO80G, SER82G, THR110G, THR44G, THR52H, THR53H, TYR42H, TYR48H, VAL114G
• J-K: ALA131K, ALA141J, ALA142J, ALA148K, ALA16K, ALA177J, ALA179J, ALA187J, ALA197J, ALA25K, ALA26K, ALA280J, ALA289J, ALA340J, ALA64K, ALA84K, ALA91K, ALA93K, ARG104J, ARG135J, ARG139J, ARG140J, ARG144J, ARG147K, ARG149K, ARG153J, ARG175J, ARG196J, ARG23K, ARG24K, ARG260J, ARG32K, ARG334J, ARG346J, ARG433J, ARG438J, ASN137K, ASN190J, ASN198J, ASN343J, ASP109J, ASP138K, ASP143J, ASP170J, ASP339J, ASP98K, CYS124K, CYS128K, CYS144K, CYS182J, CYS353J, CYS83K, CYS88K, GLN120K, GLN135K, GLN253J, GLN288J, GLN35K, GLN36K, GLN81K, GLN86J, GLU108J, GLU123K, GLU137J, GLU139K, GLU13K, GLU143K, GLU146J, GLU151K, GLU164K, GLU178K, GLU180K, GLU193J, GLU21K, GLU24J, GLU265J, GLU333J, GLU351J, GLU59K, GLU94K, GLU95J, GLU95K, GLU97J, GLY126K, GLY136J, GLY173K, GLY176J, GLY178J, GLY194J, GLY213J, GLY22J, GLY22K, GLY256J, GLY25J, GLY262J, GLY281J, GLY354J, GLY62K, GLY92K, GLY99J, HIS129K, HIS172J, HIS174J, HIS174K, HIS175K, HIS177K, HIS350J, ILE132J, ILE134K, ILE181J, ILE254J, ILE27K, ILE287J, ILE290J, ILE291J, ILE329J, ILE331J, LEU100K, LEU125K, LEU150K, LEU154K, LEU171J, LEU188J, LEU192J, LEU195J, LEU211J, LEU284J, LEU31K, LEU330J, LEU344J, LEU436J, LEU86K, LEU90K, LEU96K, LYS102J, LYS121K, LYS150J, LYS17K, LYS214J, LYS23J, LYS259J, LYS355J, LYS89K, MET189J, MET28K, MET337J, MET341J, MET61K, PHE101J, PHE347J, PHE66K, PRO132K, PRO140K, PRO199J, PRO19K, PRO20K, PRO257J, PRO261J, PRO299J, PRO29K, PRO332J, PRO432J, PRO434J, PRO98J, SER100J, SER127K, SER191J, SER255J, SER295J, SER336J, SER352J, SER435J, SER65K, SER68K, SER87K, SER96J, THR130K, THR146K, THR14K, THR55K, THR58K, THR85K, TRP212J, TRP279J, TRP27J, TRP342J, TRP437J, TRP97K, TYR105J, TYR131J, TYR133J, TYR138J, TYR141K, TYR180J, TYR18K, TYR264J, TYR348J, TYR67K, TYR69K, TYR70K, TYR88J, TYR99K, VAL110J, VAL122K, VAL129J, VAL133K, VAL134J, VAL145K, VAL173J, VAL176K, VAL179K, VAL21J, VAL258J, VAL263J, VAL328J, VAL335J, VAL338J, VAL431J, VAL53K, VAL60K, VAL63K, VAL82K
• J-L: ALA103L, ALA105L, ALA177J, ALA179J, ALA197J, ALA349J, ALA364J, ALA372J, ALA389J, ALA403J, ALA44L, ALA80L, ALA81L, ALA86L, ARG101L, ARG156L, ARG161L, ARG162L, ARG189L, ARG196J, ARG200J, ARG205L, ARG360J, ARG397J, ARG440L, ARG46L, ASN114L, ASN190J, ASN198J, ASN369J, ASN386J, ASP201L, ASP383J, ASP404J, CYS181L, CYS182J, CYS184L, CYS34L, CYS353J, CYS356J, CYS359J, CYS400J, CYS45L, CYS83L, GLN104L, GLN378J, GLU102L, GLU109L, GLU158L, GLU192L, GLU193J, GLU198L, GLU204L, GLU351J, GLU361J, GLU380J, GLU385J, GLU388J, GLU395J, GLU439L, GLY106L, GLY178J, GLY194J, GLY206L, GLY213J, GLY354J, GLY362J, GLY365J, GLY379J, GLY396J, GLY43L, HIS115L, HIS183L, HIS208L, HIS350J, ILE181J, ILE182L, ILE203L, ILE211L, ILE374J, ILE394J, ILE42L, ILE437L, LEU112L, LEU113L, LEU130L, LEU195J, LEU200L, LEU201J, LEU370J, LEU387J, LEU390J, LEU391J, LEU393J, LEU402J, LEU435L, LEU49L, LEU79L, LYS185L, LYS202J, LYS355J, LYS373J, LYS382J, LYS438L, LYS78L, MET107L, MET367J, MET47L, PHE110L, PHE157L, PHE159L, PHE202L, PHE210L, PHE33L, PHE347J, PHE366J, PHE371J, PHE399J, PRO199J, PRO203J, PRO204J, PRO358J, PRO392J, PRO401J, PRO41L, PRO442L, PRO77L, SER209J, SER352J, SER398J, SER40L, SER82L, THR111L, THR155L, THR160L, THR209L, THR357J, THR85L, TRP212J, TRP408J, TYR140L, TYR180J, TYR348J, VAL108L, VAL153L, VAL188L, VAL207L, VAL363J, VAL368J, VAL50L, VAL84L, VAL99L
• J-M: MET321M, PHE366J
• J-Q: ASP383J, HIS350J, HIS90Q, LYS373J, LYS78Q
• K-L: ALA50K, ALA64K, ARG205L, ARG24K, ARG42K, ARG440L, ARG45K, ASP197L, ASP201L, ASP215L, GLN120K, GLU123K, GLU192L, GLU198L, GLU204L, GLU21K, GLU44K, GLU47K, GLU48K, GLU59K, GLY196L, GLY206L, GLY212L, GLY54K, GLY62K, ILE203L, ILE211L, ILE27K, ILE46K, LEU200L, LEU218L, LYS185L, LYS460L, MET214L, MET61K, PHE191L, PHE202L, PHE210L, PHE216L, PHE66K, PHE72K, PRO219L, PRO43K, PRO442L, PRO57K, SER65K, SER68K, THR209L, THR213L, THR55K, THR56K, THR58K, TYR67K, TYR69K, VAL122K, VAL188L, VAL199L, VAL60K, VAL63K
• K-Q: ARG114Q, ARG121Q, ASP98K, GLU102K, GLU110K, GLY109K, HIS90Q, LYS107Q, PRO74K, TYR70K
• L-M: ALA105L, ALA127L, ALA323M, ARG133L, ARG156L, ARG161L, ARG245L, ARG9L, ASN114L, ASN246L, ASN306M, ASP118L, ASP132L, ASP304M, CYS119L, CYS122L, CYS128L, GLN131L, GLN308M, GLU109L, GLU129L, GLU136L, GLU141L, GLU158L, GLU318M, GLU322M, GLU333M, GLY106L, GLY125L, GLY126L, GLY138L, GLY334M, HIS115L, HIS315M, HIS327M, HIS330M, HIS336M, ILE309M, ILE325M, LEU112L, LEU113L, LEU117L, LEU130L, LEU139L, LEU151L, LEU316M, LEU317M, LYS124L, LYS329M, LYS339M, MET321M, PHE110L, PHE157L, PHE159L, PHE328M, PHE335M, PHE33L, PRO116L, PRO120L, PRO152L, PRO301M, PRO305M, PRO307M, PRO311M, PRO312M, PRO313M, SER320M, THR111L, THR121L, THR134L, THR155L, THR310M, THR319M, THR332M, TRP247L, TYR137L, TYR140L, TYR154L, TYR326M, VAL108L, VAL135L, VAL153L, VAL232L, VAL324M
• L-N: ARG133L, ARG163N, ARG189N, ARG270L, ASP132L, ASP29L, GLU129L, GLU136L, GLU169N, GLU250L, GLU251L, GLU273L, HIS428L, LYS185N, LYS190N, THR182N, VAL30L
• L-P: ARG241L, ARG243L, ARG270L, ARG86P, ASP118L, ASP123L, GLU248L, GLU71P, GLU74P, GLU85P, HIS167L, LYS166L
• L-Q: ARG180L, ARG205L, ARG85Q, ARG88Q, ASP165L, ASP71Q, GLU158L, GLU179L, GLU204L, GLU32Q, GLU34Q, GLU65Q, GLY64Q, HIS163L, HIS167L, HIS168L, HIS208L, HIS76Q, HIS90Q, HIS92Q, LYS166L, LYS33Q, LYS78Q
• M-N: ARG116N, ARG147N, ARG171N, ARG189N, ARG193N, ARG249M, ARG367M, ARG371M, ARG409M, ARG73M, ARG87N, ARG91N, ASN112N, ASN306M, ASP120N, ASP140N, ASP360M, ASP408M, ASP51N, ASP62N, GLN379M, GLU139N, GLU154N, GLU18N, GLU333M, GLU341M, GLU352M, GLU67M, GLU71M, GLU73N, GLY54N, GLY85N, HIS336M, HIS63M, HIS72M, LEU174N, LYS103M, LYS148N, LYS177N, LYS190N, LYS329M, LYS339M, LYS369M, LYS68M, PHE113N, PRO145N, SER238M, SER363M, TYR150N, TYR192N, TYR366M
• M-O: ARG143O, ARG167M, ARG83O, ARG84M, ASN120O, ASP408M, GLU161M, GLU49O, HIS58M, HIS63M, ILE59M, LYS87O, THR64M, TYR121O
• M-P: ALA62P, ARG174M, ARG314M, ARG36P, ASP158M, ASP181M, GLN166M, GLN77M, GLU106P, GLU161M, GLU180M, GLU185M, GLU189M, GLY165M, HIS170M, HIS38P, LYS179M, LYS34P, PHE100P
• M-Q: ARG314M, ARG43Q, ARG46Q, ARG75Q, ASP39Q, GLU318M, GLU45Q, HIS315M, HIS76Q
• N-O: ASN119O, ASP140N, GLU139N, LEU152N, LYS86O, LYS87O, THR155N, TYR121O
• N-P: ARG160N, ARG163N, ASP128P, ASP135P, GLU161N, GLU71P, GLU92P, THR157N, TYR66P
• O-P: ARG143O, ARG148P, ARG166O, ARG97P, ASN119O, ASP123P, ASP128P, GLN125O, GLU120P, GLU125P, GLU145O, GLU149P, GLU165O, GLU168O, GLY116O, HIS38P, LEU96P, LYS144P, LYS156O, SER114O, TYR136O
• P-Q: ARG167P, ARG43Q, ASP36Q, GLU169P, GLU171P, GLU34Q, GLU45Q, GLU85P, HIS46P, LYS33Q, LYS52P
• S-T: ALA177S, ALA84T, ARG104S, ARG139S, ARG140S, ARG147T, ARG175S, ARG196S, ARG24T, ARG260S, ARG32T, ARG433S, ARG438S, ASN343S, ASP109S, ASP138T, ASP143S, ASP339S, GLN135T, GLU108S, GLU123T, GLU137S, GLU139T, GLU143T, GLU178T, GLU180T, GLU193S, GLU21T, GLU24S, GLU265S, GLU351S, GLU59T, GLU94T, GLU95T, GLY136S, GLY194S, HIS172S, HIS174S, HIS174T, HIS175T, HIS350S, LEU86T, LYS17T, LYS214S, LYS259S, LYS89T, TRP437S, TYR131S, TYR141T, TYR69T, VAL179T, VAL263S
• S-U: ARG156U, ARG162U, ARG196S, ARG200S, ARG205U, ARG360S, ARG397S, ARG440U, ARG46U, ASP201U, ASP383S, CYS353S, GLU158U, GLU193S, GLU204U, GLU351S, GLU361S, GLU385S, GLU395S, GLY206U, HIS115U, HIS183U, HIS208U, HIS350S, LYS185U, LYS355S, LYS373S, LYS78U, PHE202U, SER398S
• S-Z: ASP383S, HIS350S, HIS90Z, LYS373S, LYS78Z
• T-U: ARG205U, ARG440U, ASP201U, ASP215U, GLU192U, GLU198U, GLU47T, GLU59T, PHE66T, THR56T
• T-Z: ARG114Z, ARG121Z, ASP98T, GLU102T, GLU110T, GLY109T, HIS90Z, LYS107Z, PRO74T, TYR70T
• U-V: ARG161U, ASP118U, ASP132U, GLU136U, GLU322V, GLU333V, HIS115U, HIS336V, LYS329V, MET321V
• U-W: ARG133U, ARG163W, ARG189W, ARG270U, ASP132U, ASP29U, GLU129U, GLU136U, GLU169W, GLU250U, GLU251U, GLU273U, GLY187W, HIS428U, LYS185W, LYS190W, VAL30U
• U-Y: ARG178U, ARG241U, ARG243U, ARG270U, ARG86Y, ASP118U, ASP123U, GLU248U, GLU71Y, GLU74Y, GLU85Y, HIS167U, LYS166U
• U-Z: ARG180U, ARG205U, ARG85Z, ARG88Z, ASP165U, ASP71Z, GLU158U, GLU179U, GLU204U, GLU32Z, GLU34Z, GLU65Z, GLY64Z, HIS163U, HIS167U, HIS168U, HIS208U, HIS76Z, HIS90Z, HIS92Z, LYS166U, LYS33Z, LYS78Z
• V-W: ARG116W, ARG147W, ARG171W, ARG189W, ARG193W, ARG249V, ARG367V, ARG371V, ARG409V, ARG73V, ARG87W, ARG91W, ASN112W, ASN306V, ASP120W, ASP140W, ASP360V, ASP51W, ASP62W, GLN379V, GLU139W, GLU154W, GLU18W, GLU333V, GLU341V, GLU352V, GLU67V, GLU71V, GLU73W, GLY54W, GLY85W, HIS336V, HIS63V, HIS72V, LEU174W, LEU378V, LYS103V, LYS148W, LYS177W, LYS190W, LYS329V, LYS339V, LYS369V, LYS68V, PRO145W, SER238V, SER363V, TYR150W, TYR192W, TYR366V
• V-X: ARG143X, ARG167V, ARG83X, ARG84V, ASN120X, ASP408V, GLU161V, GLU49X, HIS58V, HIS63V, ILE59V, LYS87X, THR64V, TYR121X
• V-Y: ALA62Y, ARG174V, ARG314V, ARG36Y, ASP158V, ASP181V, GLN166V, GLN77V, GLU106Y, GLU161V, GLU180V, GLU185V, GLU189V, GLY165V, HIS170V, HIS38Y, LYS179V, LYS34Y, PHE100Y
• V-Z: ARG314V, ARG43Z, ARG46Z, ARG75Z, ASP39Z, GLU318V, GLU45Z, HIS315V, HIS76Z
• W-X: ASN119X, ASP140W, GLU139W, LEU152W, LYS86X, LYS87X, THR155W, TYR121X
• W-Y: ARG160W, ARG163W, ASP128Y, ASP135Y, GLU161W, GLU71Y, GLU92Y, THR157W, TYR66Y
• X-Y: ARG143X, ARG148Y, ARG166X, ARG97Y, ASP123Y, ASP128Y, GLN125X, GLN153X, GLU120Y, GLU125Y, GLU145X, GLU149Y, GLU165X, GLU168X, GLY116X, HIS38Y, LEU96Y, LYS144Y, LYS156X, SER114X, TYR136X
• Y-Z: ARG167Y, ARG43Z, ASP36Z, GLU169Y, GLU171Y, GLU34Z, GLU45Z, GLU85Y, HIS46Y, LYS33Z, LYS52Y