2FRM

crystal structure of the lactate dehydrogenase from cryptosporidium parvum

• Total interactions analyzed: 6
• Total true interactions: 3
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 184
  • Norm. En. per Res.: -3.8712
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-84.8218	-26.1478	-592.751	-703.7207	186	27	12	23238	4	28	29
B-C	-5.8324	-10.97	-144.924	-161.7264	61	18	5	6644	0	24	17
C-D	-83.1077	-44.9744	-584.227	-712.3091	184	25	12	22870	5	28	29

Interface residues

• A-B: ALA164A, ALA164B, ALA177A, ALA177B, ALA184A, ALA184B, ALA189A, ALA189B, ALA235A, ALA235B, ALA240A, ALA240B, ALA246A, ALA246B, ALA249A, ALA249B, ALA251A, ALA251B, ALA252A, ALA252B, ALA253A, ALA253B, ALA254A, ALA254B, ALA37A, ALA37B, ALA55A, ALA55B, ALA63A, ALA63B, ARG171A, ARG171B, ARG173A, ARG173B, ARG20A, ARG20B, ASN183A, ASN183B, ASN241A, ASN241B, ASN35A, ASN35B, ASP168A, ASP168B, ASP186A, ASP186B, ASP240A, ASP240B, ASP43A, ASP43B, ASP65A, ASP65B, GLN178A, GLN178B, GLN30A, GLN30B, GLN60A, GLN60B, GLU238A, GLU238B, GLU259A, GLU259B, GLU56A, GLU56B, GLY165A, GLY165B, GLY181B, GLY244B, GLY29A, GLY29B, GLY32A, GLY32B, GLY33A, GLY33B, GLY57A, GLY57B, GLY61A, GLY61B, GLY73A, GLY73B, GLY80B, HIS231A, HIS231B, HIS68A, HIS68B, ILE234A, ILE234B, ILE31A, ILE31B, ILE36A, ILE36B, ILE39A, ILE39B, ILE58A, ILE58B, ILE66A, ILE66B, ILE79A, ILE79B, LEU167A, LEU167B, LEU242A, LEU242B, LEU45A, LEU51A, LEU51B, LEU64A, LEU64B, LYS237A, LYS237B, LYS243A, LYS243B, LYS256A, LYS256B, LYS42A, LYS42B, LYS62A, LYS62B, LYS77A, LYS77B, MET163A, MET163B, MET70A, MET70B, MET72A, MET72B, PHE172A, PHE172B, PHE175A, PHE175B, PHE248A, PHE248B, PHE73A, PHE73B, PRO250A, PRO250B, PRO59A, PRO59B, SER169A, SER169B, SER170A, SER170B, SER185A, SER185B, SER188A, SER188B, SER28A, SER28B, SER69A, SER69B, SER74A, SER74B, THR174A, THR174B, THR232A, THR232B, THR243A, THR243B, THR245A, THR245B, THR67A, THR67B, THR75A, THR75B, TRP236A, TRP236B, TYR247A, TYR247B, TYR38A, TYR38B, VAL166A, VAL166B, VAL182A, VAL182B, VAL187A, VAL187B, VAL239A, VAL239B, VAL255A, VAL255B, VAL40A, VAL40B, VAL71A, VAL71B, VAL78A, VAL78B
• B-C: ALA117B, ALA117C, ARG109B, ARG109C, ARG118B, ARG118C, ASN116B, ASN116C, ASN320B, ASN320C, ASN323B, ASN323C, ASP107B, ASP107C, ASP121B, ASP121C, ASP197B, ASP197C, GLU111B, GLU111C, GLU317B, GLU317C, GLU321B, GLU321C, GLY115B, GLY115C, HIS148B, HIS148C, ILE100B, ILE100C, ILE319C, ILE325B, ILE325C, LEU112B, LEU112C, LEU113B, LEU113C, LEU329B, LEU329C, LYS151C, LYS327B, LYS327C, MET145C, PHE114B, PHE114C, PRO141B, PRO141C, SER110B, SER110C, SER318C, SER326B, SER326C, THR324B, THR324C, VAL144B, VAL144C, VAL152C, VAL322B, VAL322C, VAL328B, VAL328C
• C-D: ALA164C, ALA164D, ALA177C, ALA177D, ALA184C, ALA184D, ALA189C, ALA189D, ALA235C, ALA235D, ALA240C, ALA240D, ALA246C, ALA246D, ALA249C, ALA249D, ALA251C, ALA251D, ALA252C, ALA252D, ALA253C, ALA253D, ALA254C, ALA254D, ALA37C, ALA37D, ALA55C, ALA55D, ALA63C, ALA63D, ARG171C, ARG171D, ARG173C, ARG173D, ARG20C, ARG20D, ASN183C, ASN183D, ASN241C, ASN241D, ASN35C, ASN35D, ASP168C, ASP168D, ASP186C, ASP186D, ASP240C, ASP240D, ASP43C, ASP43D, ASP65C, ASP65D, GLN178C, GLN178D, GLN30C, GLN30D, GLN60C, GLN60D, GLU238C, GLU238D, GLU259C, GLU259D, GLU56C, GLU56D, GLY165C, GLY165D, GLY181D, GLY244D, GLY29C, GLY29D, GLY32C, GLY32D, GLY33C, GLY33D, GLY57C, GLY57D, GLY61C, GLY61D, GLY73C, GLY73D, GLY80C, GLY80D, HIS231C, HIS231D, HIS68C, HIS68D, ILE234C, ILE234D, ILE31C, ILE31D, ILE36C, ILE36D, ILE39C, ILE39D, ILE58C, ILE58D, ILE66C, ILE66D, ILE79C, LEU167C, LEU167D, LEU242C, LEU242D, LEU45D, LEU51C, LEU51D, LEU64C, LEU64D, LYS237C, LYS237D, LYS243C, LYS243D, LYS256C, LYS256D, LYS265C, LYS42C, LYS42D, LYS62C, LYS62D, LYS77C, LYS77D, MET163C, MET163D, MET257C, MET70C, MET70D, MET72C, MET72D, PHE172C, PHE172D, PHE175C, PHE175D, PHE248C, PHE248D, PHE73C, PHE73D, PRO250C, PRO250D, PRO59C, PRO59D, SER169C, SER169D, SER170C, SER170D, SER185C, SER185D, SER188C, SER28C, SER28D, SER69C, SER69D, SER74C, SER74D, THR174C, THR174D, THR232C, THR243C, THR243D, THR245C, THR245D, THR67C, THR67D, THR75C, THR75D, TRP236C, TRP236D, TYR247C, TYR247D, TYR38C, TYR38D, VAL166C, VAL166D, VAL182C, VAL182D, VAL187C, VAL187D, VAL239C, VAL239D, VAL255C, VAL255D, VAL40C, VAL40D, VAL71C, VAL71D