2FO1

crystal structure of the csl-notch-mastermind ternary complex bound to dna

• Total interactions analyzed: 10
• Total true interactions: 3
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 92
  • Norm. En. per Res.: -3.5831
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-31.6461	-28.2598	-246.005	-305.9108	116	12	6	11097	3	54	46
A-E	-84.8218	-142.3746	-546.421	-773.6174	239	60	7	23195	16	143	122
D-E	-34.5319	-125.5281	-169.583	-329.643	92	23	1	8893	9	48	31

Interface residues

• A-D: ALA283A, ALA288A, ALA345A, ALA556A, ALA576A, ALA77D, ALA79D, ALA90D, ALA94D, ALA97D, ARG102D, ARG111D, ARG299A, ARG578A, ARG604A, ARG644A, ARG71D, ARG73D, ARG78D, ARG85D, ARG93D, ASN101D, ASN344A, ASN557A, ASN589A, ASN80D, ASP106D, ASP303A, ASP571A, ASP645A, ASP646A, CYS351A, CYS611A, GLN281A, GLN282A, GLN300A, GLN301A, GLN346A, GLN72D, GLN92D, GLU105D, GLU107D, GLU108D, GLU285A, GLU298A, GLU354A, GLU575A, GLU600A, GLU67D, GLU68D, GLU75D, GLU82D, GLY291A, GLY307A, GLY350A, GLY352A, GLY356A, GLY357A, GLY572A, GLY66D, HIS279A, HIS573A, HIS610A, HIS64D, HIS70D, HIS98D, ILE278A, ILE290A, ILE355A, ILE559A, ILE89D, LEU286A, LEU590A, LEU609A, LEU60D, LEU69D, LEU76D, LEU99D, LYS110D, LYS587A, LYS591A, MET353A, MET88D, PHE100D, PHE347A, PHE348A, PHE358A, PHE586A, PHE603A, PHE63D, PRO558A, PRO561A, PRO588A, PRO86D, SER297A, SER305A, SER560A, SER577A, SER605A, SER612A, SER74D, THR104D, THR284A, THR601A, THR602A, THR96D, TYR103D, TYR289A, TYR349A, TYR81D, VAL287A, VAL555A, VAL592A, VAL599A, VAL643A, VAL95D
• A-E: ALA1030E, ALA1031E, ALA1061E, ALA1066E, ALA1101E, ALA1104E, ALA1134E, ALA1135E, ALA1136E, ALA1171E, ALA1214E, ALA1272E, ALA387A, ALA414A, ALA443A, ALA465A, ALA576A, ALA942E, ARG1051E, ARG1054E, ARG1105E, ARG1106E, ARG1128E, ARG1138E, ARG1161E, ARG1199E, ARG1208E, ARG1253E, ARG338A, ARG362A, ARG445A, ARG468A, ARG578A, ARG584A, ARG604A, ARG663A, ARG935E, ARG937E, ARG938E, ASN1053E, ASN1063E, ASN1095E, ASN1124E, ASN1137E, ASN1162E, ASN1173E, ASN1219E, ASN1284E, ASN413A, ASN441A, ASN630A, ASN941E, ASN951E, ASP1091E, ASP1093E, ASP1139E, ASP1160E, ASP1201E, ASP1238E, ASP1240E, ASP1271E, ASP1274E, ASP336A, ASP342A, ASP380A, ASP431A, ASP432A, ASP440A, ASP446A, ASP459A, ASP542A, ASP571A, ASP585A, ASP635A, CYS1092E, CYS381A, CYS509A, GLN1133E, GLN1178E, GLN1216E, GLN1237E, GLN1250E, GLN361A, GLN517A, GLU1021E, GLU1029E, GLU1094E, GLU1127E, GLU1174E, GLU1203E, GLU1239E, GLU1251E, GLU569A, GLU575A, GLU580A, GLU606A, GLU607A, GLU662A, GLU950E, GLY1032E, GLY1175E, GLY1207E, GLY1241E, GLY1252E, GLY293A, GLY389A, GLY412A, GLY447A, GLY463A, GLY566A, GLY572A, GLY574A, GLY583A, GLY634A, HIS1027E, HIS1052E, HIS1058E, HIS1132E, HIS1172E, HIS1275E, HIS1286E, HIS416A, HIS428A, HIS512A, HIS518A, HIS573A, HIS582A, HIS610A, ILE1024E, ILE1060E, ILE1073E, ILE1169E, ILE363A, ILE386A, ILE427A, ILE464A, ILE515A, ILE516A, ILE940E, LEU1100E, LEU1103E, LEU1247E, LEU1280E, LEU408A, LEU429A, LEU457A, LEU466A, LEU469A, LEU508A, LEU510A, LEU568A, LEU581A, LEU609A, LEU654A, LEU661A, LYS1025E, LYS1068E, LYS1125E, LYS1200E, LYS1204E, LYS1206E, LYS1242E, LYS223A, LYS337A, LYS339A, LYS364A, LYS382A, LYS391A, LYS456A, LYS514A, LYS543A, LYS587A, LYS659A, LYS936E, MET500A, PHE341A, PHE415A, PHE430A, PHE442A, PHE448A, PHE586A, PHE603A, PRO1023E, PRO1050E, PRO467A, PRO561A, PRO588A, PRO947E, PRO948E, SER1022E, SER1062E, SER1064E, SER1065E, SER1126E, SER1202E, SER1218E, SER360A, SER388A, SER511A, SER540A, SER567A, SER577A, SER605A, SER608A, SER657A, SER660A, SER943E, THR1028E, THR1273E, THR390A, THR426A, THR462A, THR541A, THR602A, THR632A, THR633A, TRP1059E, TRP945E, TYR1205E, TYR1213E, TYR340A, TYR383A, TYR450A, TYR507A, TYR658A, VAL1102E, VAL1170E, VAL1217E, VAL1270E, VAL359A, VAL410A, VAL444A, VAL449A, VAL458A, VAL506A, VAL565A, VAL570A, VAL636A, VAL944E
• D-E: ALA1104E, ALA1111E, ALA1134E, ALA1135E, ALA1136E, ALA1171E, ALA1283E, ALA62D, ALA77D, ALA84D, ALA90D, ARG1105E, ARG1106E, ARG1107E, ARG1108E, ARG1138E, ARG1176E, ARG1253E, ARG71D, ARG73D, ARG78D, ARG85D, ASN1063E, ASN1137E, ASN1173E, ASN1219E, ASN1284E, ASN1285E, ASN1288E, ASN61D, ASN80D, ASN91D, ASP1071E, ASP1139E, ASP1177E, ASP53D, ASP59D, GLN1178E, GLN1282E, GLN72D, GLN92D, GLU1070E, GLU1174E, GLU1251E, GLU1255E, GLU52D, GLU54D, GLU67D, GLU68D, GLU87D, GLY1141E, GLY1175E, GLY1252E, GLY58D, GLY66D, HIS1172E, HIS1286E, HIS1287E, HIS64D, HIS70D, ILE1073E, ILE1254E, ILE1289E, ILE57D, ILE89D, LEU1109E, LEU1113E, LEU60D, LEU69D, LEU76D, LYS1068E, LYS1078E, LYS1115E, LYS83D, MET88D, PHE1140E, PHE63D, PRO1221E, PRO55D, PRO86D, SER1218E, SER65D, SER74D, THR56D, TYR1112E, TYR1145E, TYR81D, VAL1074E, VAL1110E, VAL1170E, VAL1217E, VAL1256E