2FEL

3-carboxy-cis,cis-muconate lactonizing enzyme from agrobacterium radiobacter s2

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: E-H
  • Int. Res.: 239
  • Norm. En. per Res.: -4.8912
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-215.8496	-211.5933	-731.636	-1159.0789	238	30	21	28631	14	57	62
A-D	-68.4776	14.0645	-674.49	-728.9031	216	13	31	27081	0	29	35
A-C	-22.5605	-20.3614	-204.115	-247.0369	86	11	1	7306	2	4	9
A-E	0.0	0.0	-0.2624	-0.2624	3	0	0	50	0	1	0
A-F	-3.683	-24.6791	-71.7547	-100.1167	46	0	0	2444	2	22	23
B-D	-19.1074	-25.481	-193.989	-238.5773	84	11	0	7085	2	4	10
B-C	-89.2701	14.2193	-670.051	-745.1018	219	15	31	27008	0	28	36
D-C	-198.0655	-191.9643	-729.87	-1119.8998	235	25	21	28494	13	56	64
D-J	0.0	17.8786	-10.0436	7.835	17	0	0	563	0	12	10
D-K	0.0	5.5571	-5.9295	-0.3724	17	1	0	404	0	10	8
C-K	-7.0245	0.0	-7.7605	-14.785	20	0	0	450	0	5	4
E-F	-82.0006	13.8425	-573.377	-641.5351	233	44	31	26595	0	29	36
E-G	-28.5812	-22.4452	-202.328	-253.3544	86	13	1	7241	2	4	9
E-H	-223.6717	-203.2165	-742.119	-1169.0072	239	29	21	28712	14	57	62
F-G	-194.2437	-205.3505	-736.118	-1135.7122	236	25	21	28444	12	56	62
F-H	-18.99	-23.489	-199.397	-241.876	88	13	1	7256	2	4	9
F-I	0.0	-2.6867	-1.3907	-4.0773	12	0	0	120	0	3	4
F-J	0.0	0.0	-0.2396	-0.2396	4	0	0	37	0	2	2
G-H	-65.4558	13.4378	-686.167	-738.185	218	14	31	27278	0	28	37
G-I	-10.3825	-25.4823	-21.5955	-57.4603	23	2	0	743	1	19	15
G-J	-6.8607	-37.4353	-18.4972	-62.7932	35	1	0	1061	2	22	29
I-J	-222.7017	-190.638	-740.454	-1153.7937	239	27	21	28674	14	55	64
I-L	-73.9244	11.0646	-657.103	-719.9628	219	18	31	27127	0	29	35
I-K	-22.0987	-23.0523	-203.642	-248.793	86	12	1	7346	2	4	9
J-L	-29.5114	-18.5881	-199.687	-247.7864	85	14	1	7325	2	4	10
J-K	-85.672	13.104	-665.229	-737.797	219	15	31	26933	0	28	36
L-K	-187.372	-207.0978	-722.373	-1116.8428	239	32	21	28465	14	58	65

Interface residues

• A-B: ALA158A, ALA158B, ALA159A, ALA159B, ALA165A, ALA165B, ALA168A, ALA168B, ALA169A, ALA169B, ALA173A, ALA173B, ALA197A, ALA197B, ALA198A, ALA198B, ALA235A, ALA235B, ALA238A, ALA238B, ALA256A, ALA256B, ALA292A, ALA292B, ALA296A, ALA296B, ALA301A, ALA301B, ALA315A, ALA315B, ARG155A, ARG155B, ARG167A, ARG167B, ARG177A, ARG177B, ARG181A, ARG181B, ARG224A, ARG224B, ARG231A, ARG231B, ARG293A, ARG293B, ARG312A, ARG312B, ASN229A, ASN229B, ASN239A, ASN239B, ASN295A, ASN295B, ASP166A, ASP166B, ASP232A, ASP232B, ASP254A, ASP254B, ASP79A, ASP79B, GLN109A, GLN109B, GLN157A, GLN157B, GLN226A, GLN226B, GLN230A, GLN230B, GLN253A, GLN253B, GLN298A, GLN298B, GLN304A, GLN304B, GLN308A, GLN308B, GLN310A, GLN310B, GLU202A, GLU202B, GLU236A, GLU236B, GLU260A, GLU260B, GLU309A, GLU309B, GLU311A, GLU311B, GLY152A, GLY152B, GLY161A, GLY161B, GLY170A, GLY170B, GLY189A, GLY189B, GLY195A, GLY195B, GLY196A, GLY196B, GLY199A, GLY199B, GLY233A, GLY233B, GLY246A, GLY246B, GLY249A, GLY249B, GLY252A, GLY252B, GLY314A, GLY314B, GLY316A, GLY316B, GLY80A, GLY80B, HIS178A, HIS178B, HIS228A, HIS228B, HIS303A, HIS303B, ILE112A, ILE112B, ILE160A, ILE160B, ILE162A, ILE162B, ILE172A, ILE172B, ILE234A, ILE234B, ILE255A, ILE255B, ILE261A, ILE261B, ILE299A, ILE299B, LEU150A, LEU150B, LEU175A, LEU175B, LEU201A, LEU201B, LEU240A, LEU240B, LEU241A, LEU241B, LEU243A, LEU243B, LEU248A, LEU248B, LEU257A, LEU257B, LEU288A, LEU288B, LEU291A, LEU291B, LEU302A, LEU302B, LEU306A, LEU306B, LEU319A, LEU319B, LYS203A, LYS203B, LYS250A, LYS250B, MET156A, MET156B, MET258A, MET258B, MET318A, MET318B, MET327A, MET327B, PHE185A, PHE185B, PHE237A, PHE237B, PHE251A, PHE251B, PHE294A, PHE294B, PRO174A, PRO174B, PRO225A, PRO225B, SER108A, SER108B, SER242A, SER242B, SER300A, SER300B, SER305A, SER305B, SER313A, SER313B, THR107A, THR107B, THR151A, THR151B, THR154A, THR154B, THR163A, THR163B, THR184A, THR184B, THR200A, THR200B, THR245A, THR245B, THR247A, THR247B, THR290A, THR290B, TRP171A, TRP171B, TRP227A, TRP227B, TRP317A, TRP317B, TRP321A, TRP321B, TYR153A, TYR153B, VAL244A, VAL244B, VAL289A, VAL289B, VAL297A, VAL297B, VAL307A, VAL307B, VAL81A, VAL81B, VAL82A, VAL82B
• A-D: ALA256A, ALA256D, ALA26A, ALA26D, ALA285A, ALA285D, ALA28A, ALA28D, ALA292A, ALA292D, ALA296A, ALA296D, ALA301A, ALA301D, ALA315A, ALA315D, ALA330A, ALA330D, ALA67A, ALA67D, ALA71A, ALA71D, ALA77A, ALA77D, ARG119A, ARG119D, ARG293A, ARG293D, ARG312A, ARG312D, ARG340A, ARG340D, ARG73A, ARG73D, ASN281A, ASN281D, ASN284A, ASN284D, ASN295A, ASN295D, ASP17A, ASP17D, ASP29A, ASP29D, ASP31A, ASP31D, ASP68A, ASP68D, ASP79A, ASP79D, GLN253A, GLN253D, GLN298A, GLN298D, GLN304A, GLN304D, GLN310A, GLN310D, GLN326A, GLN326D, GLN344A, GLN344D, GLU22A, GLU22D, GLU260A, GLU260D, GLU286A, GLU286D, GLU309A, GLU309D, GLU320A, GLU320D, GLU7A, GLU7D, GLU85A, GLU85D, GLY13A, GLY13D, GLY16A, GLY16D, GLY314A, GLY314D, GLY316A, GLY316D, GLY75A, GLY75D, GLY80A, GLY80D, HIS303A, HIS303D, HIS74A, HIS74D, HIS8A, HIS8D, ILE112A, ILE112D, ILE20A, ILE20D, ILE21A, ILE21D, ILE299A, ILE299D, ILE30A, ILE30D, LEU11A, LEU11D, LEU14A, LEU14D, LEU23A, LEU23D, LEU257A, LEU257D, LEU288A, LEU288D, LEU291A, LEU291D, LEU302A, LEU302D, LEU319A, LEU319D, LEU322A, LEU322D, LEU324A, LEU324D, LEU3A, LEU3D, LEU72A, LEU72D, LEU86A, LEU86D, LYS27A, LYS27D, LYS78A, LYS78D, MET156A, MET156D, MET318A, MET318D, MET327A, MET327D, MET33A, MET33D, MET69A, MET69D, PHE10A, PHE10D, PHE15A, PHE15D, PHE24A, PHE24D, PHE294A, PHE294D, PHE6A, PHE6D, PRO282A, PRO282D, PRO325A, PRO325D, PRO5A, PRO5D, PRO9A, PRO9D, SER115A, SER115D, SER12A, SER12D, SER18A, SER18D, SER25A, SER25D, SER2A, SER2D, SER300A, SER300D, SER305A, SER305D, SER313A, SER313D, SER4A, SER4D, SER70A, SER70D, THR287A, THR287D, THR290A, THR290D, THR323A, THR323D, THR329A, THR329D, THR333A, THR333D, TRP317A, TRP317D, TRP321A, TRP321D, VAL283A, VAL283D, VAL289A, VAL289D, VAL297A, VAL297D, VAL307A, VAL307D, VAL328A, VAL328D, VAL337A, VAL337D, VAL76A, VAL76D, VAL81A, VAL81D, VAL82A, VAL82D, VAL83A, VAL83D
• A-C: ALA158A, ALA158C, ALA256A, ALA256C, ALA259A, ALA259C, ALA285A, ALA285C, ALA296A, ALA296C, ALA301A, ALA301C, ALA315A, ALA315C, ARG155A, ARG155C, ARG167A, ARG167C, ARG293A, ARG293C, ASN281A, ASN281C, ASN284A, ASN284C, ASP254A, ASP254C, GLN157A, GLN157C, GLN253A, GLN253C, GLN304A, GLN304C, GLU260A, GLU260C, GLU286A, GLU286C, GLY152A, GLY252A, GLY252C, GLY262A, GLY262C, HIS303A, ILE255A, ILE255C, ILE261A, ILE261C, ILE265A, ILE265C, LEU14A, LEU14C, LEU257A, LEU257C, LEU267A, LEU267C, LEU319A, LEU319C, MET156A, MET156C, MET258A, MET258C, PHE15A, PHE15C, PRO282A, PRO282C, SER300A, SER300C, SER305A, SER305C, THR151A, THR151C, THR154A, THR154C, THR287A, THR287C, THR290A, THR290C, TYR153A, TYR153C, VAL283A, VAL283C, VAL289A, VAL289C, VAL297A, VAL297C, VAL307A, VAL307C
• A-E: GLN97A, HIS74E, LYS78E
• A-F: ALA142F, ALA342F, ALA343F, ALA67A, ALA71A, ALA77A, ALA92A, ALA93A, ALA95A, ALA99A, ARG144F, ARG266F, ARG347F, ARG73A, ARG88A, ARG91A, ASP100A, ASP136F, ASP140F, ASP145F, ASP346F, ASP68A, GLN344F, GLN89A, GLN97A, GLU85A, GLY139F, GLY269F, GLY270F, GLY75A, GLY96A, HIS147F, HIS74A, ILE345F, LEU141F, LEU267F, LEU348F, LEU72A, LYS148F, LYS78A, MET69A, SER143F, SER268F, SER70A, THR137F, VAL94A
• B-D: ALA158B, ALA158D, ALA256B, ALA256D, ALA259B, ALA259D, ALA285B, ALA285D, ALA296B, ALA296D, ALA301B, ALA301D, ALA315B, ALA315D, ARG155B, ARG155D, ARG167B, ARG167D, ARG293B, ARG293D, ASN281B, ASN281D, ASN284B, ASN284D, ASP254B, ASP254D, GLN157B, GLN157D, GLN253B, GLN253D, GLN304B, GLN304D, GLU260B, GLU260D, GLU286B, GLU286D, GLY252B, GLY252D, GLY262B, GLY262D, HIS303D, ILE255B, ILE255D, ILE261B, ILE261D, ILE265B, ILE265D, LEU14B, LEU14D, LEU257B, LEU257D, LEU267B, LEU267D, LEU319B, LEU319D, MET156B, MET156D, MET258B, MET258D, PHE15B, PHE15D, PRO282B, PRO282D, SER300B, SER300D, SER305B, SER305D, THR151B, THR154B, THR154D, THR287B, THR287D, THR290B, THR290D, TYR153B, TYR153D, VAL283B, VAL283D, VAL289B, VAL289D, VAL297B, VAL297D, VAL307B, VAL307D
• B-C: ALA256B, ALA256C, ALA26B, ALA26C, ALA285B, ALA285C, ALA28B, ALA28C, ALA292B, ALA292C, ALA296B, ALA296C, ALA301B, ALA301C, ALA315B, ALA315C, ALA330B, ALA330C, ALA67B, ALA67C, ALA71B, ALA71C, ALA77B, ALA77C, ARG119B, ARG119C, ARG293B, ARG293C, ARG312B, ARG312C, ARG340B, ARG340C, ARG73B, ARG73C, ASN281B, ASN281C, ASN284B, ASN284C, ASN295B, ASN295C, ASP17B, ASP17C, ASP29B, ASP29C, ASP31B, ASP31C, ASP68B, ASP68C, ASP79B, ASP79C, GLN253B, GLN253C, GLN298B, GLN298C, GLN304B, GLN304C, GLN310B, GLN310C, GLN326B, GLN326C, GLN344B, GLN344C, GLU22B, GLU22C, GLU260B, GLU260C, GLU286B, GLU286C, GLU309B, GLU309C, GLU320B, GLU320C, GLU7B, GLU7C, GLU85B, GLU85C, GLY13B, GLY13C, GLY16B, GLY16C, GLY269B, GLY270B, GLY314B, GLY314C, GLY316B, GLY316C, GLY75B, GLY75C, GLY80B, GLY80C, HIS303B, HIS303C, HIS74B, HIS74C, HIS8B, HIS8C, ILE112B, ILE112C, ILE20B, ILE20C, ILE21B, ILE21C, ILE299B, ILE299C, ILE30B, ILE30C, LEU11B, LEU11C, LEU14B, LEU14C, LEU23B, LEU23C, LEU257B, LEU257C, LEU288B, LEU288C, LEU291B, LEU291C, LEU302B, LEU302C, LEU319B, LEU319C, LEU322B, LEU322C, LEU324B, LEU324C, LEU336C, LEU3B, LEU3C, LEU72B, LEU72C, LEU86B, LEU86C, LYS27B, LYS27C, LYS78B, LYS78C, MET156B, MET156C, MET318B, MET318C, MET327B, MET327C, MET33B, MET33C, MET69B, MET69C, PHE10B, PHE10C, PHE15B, PHE15C, PHE24B, PHE24C, PHE294B, PHE294C, PHE6B, PHE6C, PRO282B, PRO282C, PRO325B, PRO325C, PRO5B, PRO5C, PRO9B, PRO9C, SER115B, SER115C, SER12B, SER12C, SER18B, SER18C, SER25B, SER25C, SER2B, SER2C, SER300B, SER300C, SER305B, SER305C, SER313B, SER313C, SER4B, SER4C, SER70B, SER70C, THR287B, THR287C, THR290B, THR290C, THR323B, THR323C, THR329B, THR329C, THR333B, THR333C, TRP317B, TRP317C, TRP321B, TRP321C, VAL283B, VAL283C, VAL289B, VAL289C, VAL297B, VAL297C, VAL307B, VAL307C, VAL328B, VAL328C, VAL337B, VAL337C, VAL76B, VAL76C, VAL81B, VAL81C, VAL82B, VAL82C, VAL83B, VAL83C
• D-C: ALA158C, ALA158D, ALA159C, ALA159D, ALA165C, ALA165D, ALA168C, ALA168D, ALA169C, ALA169D, ALA173C, ALA173D, ALA197C, ALA197D, ALA198C, ALA198D, ALA235C, ALA235D, ALA238C, ALA238D, ALA256C, ALA256D, ALA292C, ALA292D, ALA296C, ALA296D, ALA301C, ALA301D, ALA315C, ALA315D, ARG155C, ARG155D, ARG167C, ARG167D, ARG177C, ARG177D, ARG181C, ARG181D, ARG224C, ARG224D, ARG231C, ARG231D, ARG293C, ARG293D, ARG312C, ARG312D, ASN229C, ASN229D, ASN239C, ASN239D, ASN295C, ASN295D, ASP166C, ASP166D, ASP232C, ASP232D, ASP254C, ASP254D, ASP79C, ASP79D, GLN109C, GLN109D, GLN157C, GLN157D, GLN226C, GLN226D, GLN230C, GLN230D, GLN253C, GLN253D, GLN298C, GLN298D, GLN304C, GLN304D, GLN308C, GLN308D, GLN310C, GLN310D, GLU202C, GLU202D, GLU236C, GLU236D, GLU260C, GLU260D, GLU309C, GLU309D, GLU311C, GLU311D, GLY152C, GLY152D, GLY161C, GLY161D, GLY170C, GLY170D, GLY189C, GLY189D, GLY195C, GLY195D, GLY196C, GLY196D, GLY199C, GLY199D, GLY233C, GLY233D, GLY246C, GLY246D, GLY249C, GLY249D, GLY252C, GLY252D, GLY314C, GLY314D, GLY316C, GLY316D, GLY80C, GLY80D, HIS178C, HIS178D, HIS228C, HIS228D, HIS303C, HIS303D, ILE112C, ILE112D, ILE160C, ILE160D, ILE162C, ILE162D, ILE172C, ILE172D, ILE234C, ILE234D, ILE255C, ILE255D, ILE261C, ILE261D, ILE299C, ILE299D, LEU150C, LEU150D, LEU175C, LEU175D, LEU201C, LEU201D, LEU240C, LEU240D, LEU241C, LEU241D, LEU243C, LEU243D, LEU248C, LEU248D, LEU257C, LEU257D, LEU288C, LEU288D, LEU291C, LEU291D, LEU302C, LEU302D, LEU306C, LEU306D, LEU319C, LEU319D, LYS203C, LYS203D, LYS250C, LYS250D, MET156C, MET156D, MET258C, MET258D, MET318C, MET318D, PHE185C, PHE185D, PHE237C, PHE237D, PHE251C, PHE251D, PHE294C, PHE294D, PRO174C, PRO174D, PRO225C, PRO225D, SER108C, SER108D, SER242C, SER242D, SER300C, SER300D, SER305C, SER305D, SER313C, SER313D, THR107C, THR107D, THR151C, THR151D, THR154C, THR154D, THR163C, THR163D, THR184C, THR184D, THR200C, THR200D, THR245C, THR245D, THR247C, THR247D, THR290C, THR290D, TRP171C, TRP171D, TRP227C, TRP227D, TRP317C, TRP317D, TRP321C, TRP321D, TYR153C, TYR153D, VAL244C, VAL244D, VAL289C, VAL289D, VAL297C, VAL297D, VAL307C, VAL307D, VAL81C, VAL81D, VAL82D
• D-J: ALA142D, ALA343J, ARG144D, ARG144J, ARG266J, ARG347J, ASP140D, ASP145D, ASP346J, GLN344J, GLY139D, GLY146D, GLY269J, HIS147D, LEU267J, SER143D, SER268J
• D-K: ALA71K, ALA92K, ARG88K, ASP136D, ASP68K, GLN187D, GLN89K, GLU176D, GLU183D, GLU85K, GLY132D, HIS74K, ILE135D, LEU179D, LEU180D, LYS78K, THR184D
• C-K: ALA222C, ALA92K, ALA95K, ALA98K, ALA99K, ARG91K, ASN188C, ASP100K, GLN187C, GLN97K, GLU183C, GLY220C, GLY96K, LEU180C, LEU221C, LYS101K, LYS121C, LYS217C, THR184C, VAL94K
• E-F: ALA256E, ALA256F, ALA259F, ALA26E, ALA26F, ALA285E, ALA285F, ALA28E, ALA28F, ALA292E, ALA292F, ALA296E, ALA296F, ALA301E, ALA301F, ALA315E, ALA315F, ALA330E, ALA330F, ALA67E, ALA67F, ALA71E, ALA71F, ALA77E, ALA77F, ARG119E, ARG119F, ARG167F, ARG293E, ARG293F, ARG312E, ARG312F, ARG340E, ARG340F, ARG73E, ARG73F, ASN281E, ASN281F, ASN284E, ASN284F, ASN295E, ASN295F, ASP17E, ASP17F, ASP254F, ASP29E, ASP29F, ASP31E, ASP31F, ASP68E, ASP68F, ASP79E, ASP79F, GLN253E, GLN253F, GLN298E, GLN298F, GLN304E, GLN304F, GLN310E, GLN310F, GLN326E, GLN326F, GLN344E, GLN344F, GLU22E, GLU22F, GLU260E, GLU260F, GLU264F, GLU286E, GLU286F, GLU309E, GLU309F, GLU320E, GLU320F, GLU7E, GLU7F, GLU85E, GLU85F, GLY13E, GLY13F, GLY16E, GLY16F, GLY262F, GLY269E, GLY269F, GLY314E, GLY314F, GLY316E, GLY316F, GLY349F, GLY75E, GLY75F, GLY80E, GLY80F, HIS303E, HIS303F, HIS74E, HIS74F, HIS8E, HIS8F, ILE112E, ILE112F, ILE20E, ILE20F, ILE21E, ILE21F, ILE255F, ILE261F, ILE265F, ILE299E, ILE299F, ILE30E, ILE30F, LEU11E, LEU11F, LEU14E, LEU14F, LEU150F, LEU23E, LEU23F, LEU257E, LEU257F, LEU267F, LEU288E, LEU288F, LEU291E, LEU291F, LEU302E, LEU302F, LEU319E, LEU319F, LEU322E, LEU322F, LEU324E, LEU324F, LEU348F, LEU3E, LEU3F, LEU72E, LEU72F, LEU86E, LEU86F, LYS27E, LYS27F, LYS78E, LYS78F, MET156E, MET156F, MET258F, MET318E, MET318F, MET327E, MET327F, MET33E, MET33F, MET69E, MET69F, PHE10E, PHE10F, PHE15E, PHE15F, PHE24E, PHE24F, PHE294E, PHE294F, PHE6E, PHE6F, PRO282E, PRO282F, PRO325E, PRO325F, PRO5E, PRO5F, PRO9E, PRO9F, SER115E, SER115F, SER12E, SER12F, SER18E, SER18F, SER25E, SER25F, SER263F, SER2E, SER2F, SER300E, SER300F, SER305E, SER305F, SER313E, SER313F, SER4E, SER4F, SER70E, SER70F, THR287E, THR287F, THR290E, THR290F, THR323E, THR323F, THR329E, THR329F, THR333E, THR333F, TRP171F, TRP317E, TRP317F, TRP321E, TRP321F, TYR153F, VAL283E, VAL283F, VAL289E, VAL289F, VAL297E, VAL297F, VAL307E, VAL307F, VAL328E, VAL337E, VAL337F, VAL76E, VAL76F, VAL81E, VAL81F, VAL82E, VAL82F, VAL83E, VAL83F
• E-G: ALA158E, ALA158G, ALA256E, ALA256G, ALA259E, ALA259G, ALA285E, ALA285G, ALA296E, ALA296G, ALA301E, ALA301G, ALA315E, ALA315G, ARG155E, ARG155G, ARG167E, ARG167G, ARG293E, ARG293G, ASN281E, ASN281G, ASN284E, ASN284G, ASP254E, ASP254G, GLN157E, GLN157G, GLN253E, GLN253G, GLN304E, GLN304G, GLN310G, GLU260E, GLU260G, GLU286E, GLU286G, GLY252E, GLY252G, GLY262E, GLY262G, HIS303E, ILE255E, ILE255G, ILE261E, ILE261G, ILE265E, ILE265G, LEU14E, LEU14G, LEU257E, LEU257G, LEU267E, LEU267G, LEU319E, LEU319G, LEU3E, MET156E, MET156G, MET258E, MET258G, PHE15E, PHE15G, PRO282E, PRO282G, SER300E, SER300G, SER305E, SER305G, THR151E, THR154E, THR154G, THR287E, THR287G, THR290E, THR290G, TYR153E, TYR153G, VAL283E, VAL283G, VAL289E, VAL289G, VAL297E, VAL297G, VAL307E, VAL307G
• E-H: ALA158E, ALA158H, ALA159E, ALA159H, ALA165E, ALA165H, ALA168E, ALA168H, ALA169E, ALA169H, ALA173E, ALA173H, ALA197E, ALA197H, ALA198E, ALA198H, ALA235E, ALA235H, ALA238E, ALA238H, ALA256E, ALA256H, ALA292E, ALA292H, ALA296E, ALA296H, ALA301E, ALA301H, ALA315E, ALA315H, ARG155E, ARG155H, ARG167E, ARG167H, ARG177E, ARG177H, ARG181E, ARG181H, ARG224E, ARG224H, ARG231E, ARG231H, ARG293E, ARG293H, ARG312E, ARG312H, ASN229E, ASN229H, ASN239E, ASN239H, ASN295E, ASN295H, ASP166E, ASP166H, ASP232E, ASP232H, ASP254E, ASP254H, ASP79E, ASP79H, GLN109E, GLN109H, GLN157E, GLN157H, GLN226E, GLN226H, GLN230E, GLN230H, GLN253E, GLN253H, GLN298E, GLN298H, GLN304E, GLN304H, GLN308E, GLN308H, GLN310E, GLN310H, GLU202E, GLU202H, GLU236E, GLU236H, GLU260E, GLU260H, GLU309E, GLU309H, GLU311E, GLU311H, GLY152E, GLY152H, GLY161E, GLY161H, GLY170E, GLY170H, GLY189E, GLY189H, GLY195E, GLY195H, GLY196E, GLY196H, GLY199E, GLY199H, GLY233E, GLY233H, GLY246E, GLY246H, GLY249E, GLY249H, GLY252E, GLY252H, GLY314E, GLY314H, GLY316E, GLY316H, GLY80E, GLY80H, HIS178E, HIS178H, HIS228E, HIS228H, HIS303E, HIS303H, ILE112E, ILE112H, ILE160E, ILE160H, ILE162E, ILE162H, ILE172E, ILE172H, ILE234E, ILE234H, ILE255E, ILE255H, ILE261E, ILE261H, ILE299E, ILE299H, LEU150E, LEU150H, LEU175E, LEU175H, LEU201E, LEU201H, LEU240E, LEU240H, LEU241E, LEU241H, LEU243E, LEU243H, LEU248E, LEU248H, LEU257E, LEU257H, LEU288E, LEU288H, LEU291E, LEU291H, LEU302E, LEU302H, LEU306E, LEU306H, LEU319E, LEU319H, LEU3E, LYS203E, LYS203H, LYS250E, LYS250H, MET156E, MET156H, MET258E, MET258H, MET318E, MET318H, MET327H, PHE185E, PHE185H, PHE237E, PHE237H, PHE251E, PHE251H, PHE294E, PHE294H, PRO174E, PRO174H, PRO225E, PRO225H, SER108E, SER108H, SER242E, SER242H, SER300E, SER300H, SER305E, SER305H, SER313E, SER313H, THR107E, THR107H, THR151E, THR151H, THR154E, THR154H, THR163E, THR163H, THR184E, THR184H, THR200E, THR200H, THR245E, THR245H, THR247E, THR247H, THR290E, THR290H, TRP171E, TRP171H, TRP227E, TRP227H, TRP317E, TRP317H, TRP321E, TRP321H, TYR153E, TYR153H, VAL244E, VAL244H, VAL289E, VAL289H, VAL297E, VAL297H, VAL307E, VAL307H, VAL76E, VAL81E, VAL81H, VAL82E, VAL82H
• F-G: ALA158F, ALA158G, ALA159F, ALA159G, ALA165F, ALA165G, ALA168F, ALA168G, ALA169F, ALA169G, ALA173F, ALA173G, ALA197F, ALA197G, ALA198F, ALA198G, ALA235F, ALA235G, ALA238F, ALA238G, ALA256F, ALA256G, ALA292F, ALA292G, ALA296F, ALA296G, ALA301F, ALA301G, ALA315F, ALA315G, ARG155F, ARG155G, ARG167F, ARG167G, ARG177F, ARG177G, ARG181F, ARG181G, ARG224F, ARG224G, ARG231F, ARG231G, ARG293F, ARG293G, ARG312F, ARG312G, ASN229F, ASN229G, ASN239F, ASN239G, ASN295F, ASN295G, ASP166F, ASP166G, ASP232F, ASP232G, ASP254F, ASP254G, ASP79F, ASP79G, GLN109F, GLN109G, GLN157F, GLN157G, GLN226F, GLN226G, GLN230F, GLN230G, GLN253F, GLN253G, GLN298F, GLN298G, GLN304F, GLN304G, GLN308F, GLN308G, GLN310F, GLN310G, GLU202F, GLU202G, GLU236F, GLU236G, GLU260F, GLU260G, GLU309F, GLU309G, GLU311F, GLU311G, GLY152F, GLY152G, GLY161F, GLY161G, GLY170F, GLY170G, GLY189F, GLY189G, GLY195F, GLY195G, GLY196F, GLY196G, GLY199F, GLY199G, GLY233F, GLY233G, GLY246F, GLY246G, GLY249F, GLY249G, GLY252F, GLY252G, GLY314F, GLY314G, GLY316F, GLY316G, GLY80F, GLY80G, HIS178F, HIS178G, HIS228F, HIS228G, HIS303F, HIS303G, ILE112F, ILE112G, ILE160F, ILE160G, ILE162F, ILE162G, ILE172F, ILE172G, ILE234F, ILE234G, ILE255F, ILE255G, ILE261F, ILE261G, ILE299F, ILE299G, LEU150F, LEU150G, LEU175F, LEU175G, LEU201F, LEU201G, LEU240F, LEU240G, LEU241F, LEU241G, LEU243F, LEU243G, LEU248F, LEU248G, LEU257F, LEU257G, LEU288F, LEU288G, LEU291F, LEU291G, LEU302F, LEU302G, LEU306F, LEU306G, LEU319F, LEU319G, LYS203F, LYS203G, LYS250F, LYS250G, MET156F, MET156G, MET258F, MET258G, MET318F, MET318G, MET327F, PHE185F, PHE185G, PHE237F, PHE237G, PHE251F, PHE251G, PHE294F, PHE294G, PRO174F, PRO174G, PRO225F, PRO225G, SER108F, SER108G, SER242F, SER242G, SER300F, SER300G, SER305F, SER305G, SER313F, SER313G, THR107F, THR107G, THR151F, THR151G, THR154F, THR154G, THR163F, THR163G, THR184F, THR184G, THR200F, THR200G, THR245F, THR245G, THR247F, THR247G, THR290F, THR290G, TRP171F, TRP171G, TRP227F, TRP227G, TRP317F, TRP317G, TRP321F, TRP321G, TYR153F, TYR153G, VAL244F, VAL244G, VAL289F, VAL289G, VAL297F, VAL297G, VAL307F, VAL307G, VAL81F, VAL81G, VAL82F
• F-H: ALA158F, ALA158H, ALA256F, ALA256H, ALA259F, ALA259H, ALA285F, ALA285H, ALA296F, ALA296H, ALA301F, ALA301H, ALA315F, ALA315H, ARG155F, ARG155H, ARG167F, ARG167H, ARG293F, ARG293H, ASN281F, ASN281H, ASN284F, ASN284H, ASP254F, ASP254H, GLN157F, GLN157H, GLN253F, GLN253H, GLN304F, GLN304H, GLU260F, GLU260H, GLU286F, GLU286H, GLY152F, GLY152H, GLY252F, GLY252H, GLY262F, GLY262H, HIS303F, HIS303H, ILE255F, ILE255H, ILE261F, ILE261H, ILE265F, ILE265H, LEU14F, LEU14H, LEU257F, LEU257H, LEU267F, LEU267H, LEU319F, LEU319H, MET156F, MET156H, MET258F, MET258H, PHE15F, PHE15H, PRO282F, PRO282H, SER300F, SER300H, SER305F, SER305H, THR151F, THR151H, THR154F, THR154H, THR287F, THR287H, THR290F, THR290H, TYR153F, TYR153H, VAL283F, VAL283H, VAL289F, VAL289H, VAL297F, VAL297H, VAL307F, VAL307H
• F-I: ALA208F, ALA210F, ALA213F, ARG212F, ASP206F, ASP206I, ASP223F, GLY205I, GLY209F, ILE49I, PRO225F, SER48I
• F-J: ASN188F, GLN187F, HIS147J, SER143J
• G-H: ALA256G, ALA256H, ALA26G, ALA26H, ALA285G, ALA285H, ALA28G, ALA28H, ALA292G, ALA292H, ALA296G, ALA296H, ALA301G, ALA301H, ALA315G, ALA315H, ALA330G, ALA330H, ALA67G, ALA67H, ALA71G, ALA71H, ALA77G, ALA77H, ARG119G, ARG119H, ARG293G, ARG293H, ARG312G, ARG312H, ARG340G, ARG340H, ARG73G, ARG73H, ASN281G, ASN281H, ASN284G, ASN284H, ASN295G, ASN295H, ASP17G, ASP17H, ASP29G, ASP29H, ASP31G, ASP31H, ASP68G, ASP68H, ASP79G, ASP79H, GLN253G, GLN253H, GLN298G, GLN298H, GLN304G, GLN304H, GLN310G, GLN310H, GLN326G, GLN326H, GLN344G, GLN344H, GLU22G, GLU22H, GLU260G, GLU260H, GLU286G, GLU286H, GLU309G, GLU309H, GLU320G, GLU320H, GLU7G, GLU7H, GLU85G, GLU85H, GLY13G, GLY13H, GLY16G, GLY16H, GLY269G, GLY269H, GLY314G, GLY314H, GLY316G, GLY316H, GLY75G, GLY75H, GLY80G, GLY80H, HIS303G, HIS303H, HIS74G, HIS74H, HIS8G, HIS8H, ILE112G, ILE112H, ILE20G, ILE20H, ILE21G, ILE21H, ILE299G, ILE299H, ILE30G, ILE30H, LEU11G, LEU11H, LEU14G, LEU14H, LEU23G, LEU23H, LEU257G, LEU257H, LEU288G, LEU288H, LEU291G, LEU291H, LEU302G, LEU302H, LEU319G, LEU319H, LEU322G, LEU322H, LEU324G, LEU324H, LEU3G, LEU3H, LEU72G, LEU72H, LEU86G, LEU86H, LYS27G, LYS27H, LYS78G, LYS78H, MET156G, MET156H, MET318G, MET318H, MET327G, MET327H, MET33G, MET33H, MET69G, MET69H, PHE10G, PHE10H, PHE15G, PHE15H, PHE24G, PHE24H, PHE294G, PHE294H, PHE6G, PHE6H, PRO282G, PRO282H, PRO325G, PRO325H, PRO5G, PRO5H, PRO9G, PRO9H, SER115G, SER115H, SER12G, SER12H, SER18G, SER18H, SER25G, SER25H, SER2G, SER2H, SER300G, SER300H, SER305G, SER305H, SER313G, SER313H, SER4G, SER4H, SER70G, SER70H, THR287G, THR287H, THR290G, THR290H, THR323G, THR323H, THR329G, THR329H, THR333G, THR333H, TRP317G, TRP317H, TRP321G, TRP321H, VAL283G, VAL283H, VAL289G, VAL289H, VAL297G, VAL297H, VAL307G, VAL307H, VAL328G, VAL328H, VAL337G, VAL337H, VAL76G, VAL76H, VAL81G, VAL81H, VAL82G, VAL82H, VAL83G, VAL83H
• G-I: ALA142G, ALA165G, ALA45I, ALA47I, ARG144G, ARG218I, ASP136G, ASP140G, ASP214I, ASP52I, GLN42I, GLU44I, GLU46I, GLY139G, GLY146G, HIS147G, ILE49I, LEU141G, LYS217I, PHE50I, SER143G, SER48I, THR163G
• G-J: ALA55G, ALA57G, ARG218G, ARG218J, ARG35J, ASP136J, ASP214J, ASP52G, ASP53G, GLN187G, GLN42G, GLN42J, GLU125J, GLU176J, GLU46G, GLU46J, GLU56G, GLU56J, GLY220J, GLY61G, ILE135J, ILE58G, LEU219J, LEU62G, LYS121J, LYS217G, LYS217J, MET122J, SER60G, SER63G, THR129J, THR38G, THR38J, VAL59G, VAL59J
• I-J: ALA158I, ALA158J, ALA159I, ALA159J, ALA165I, ALA165J, ALA168I, ALA168J, ALA169I, ALA169J, ALA173I, ALA173J, ALA197I, ALA197J, ALA198I, ALA198J, ALA235I, ALA235J, ALA238I, ALA238J, ALA256I, ALA256J, ALA292I, ALA292J, ALA296I, ALA296J, ALA301I, ALA301J, ALA315I, ALA315J, ARG155I, ARG155J, ARG167I, ARG167J, ARG177I, ARG177J, ARG181I, ARG181J, ARG224I, ARG224J, ARG231I, ARG231J, ARG293I, ARG293J, ARG312I, ARG312J, ASN229I, ASN229J, ASN239I, ASN239J, ASN295I, ASN295J, ASP166I, ASP166J, ASP232I, ASP232J, ASP254I, ASP254J, ASP79I, ASP79J, GLN109I, GLN109J, GLN157I, GLN157J, GLN226I, GLN226J, GLN230I, GLN230J, GLN253I, GLN253J, GLN298I, GLN298J, GLN304I, GLN304J, GLN308I, GLN308J, GLN310I, GLN310J, GLU202I, GLU202J, GLU236I, GLU236J, GLU260I, GLU260J, GLU309I, GLU309J, GLU311I, GLU311J, GLY152I, GLY152J, GLY161I, GLY161J, GLY170I, GLY170J, GLY189I, GLY189J, GLY195I, GLY195J, GLY196I, GLY196J, GLY199I, GLY199J, GLY233I, GLY233J, GLY246I, GLY246J, GLY249I, GLY249J, GLY252I, GLY252J, GLY314I, GLY314J, GLY316I, GLY316J, GLY80I, GLY80J, HIS178I, HIS178J, HIS228I, HIS228J, HIS303I, HIS303J, ILE112I, ILE112J, ILE160I, ILE160J, ILE162I, ILE162J, ILE172I, ILE172J, ILE234I, ILE234J, ILE255I, ILE255J, ILE261I, ILE261J, ILE299I, ILE299J, LEU150I, LEU150J, LEU175I, LEU175J, LEU201I, LEU201J, LEU240I, LEU240J, LEU241I, LEU241J, LEU243I, LEU243J, LEU248I, LEU248J, LEU257I, LEU257J, LEU288I, LEU288J, LEU291I, LEU291J, LEU302I, LEU302J, LEU306I, LEU306J, LEU319I, LEU319J, LYS203I, LYS203J, LYS250I, LYS250J, MET156I, MET156J, MET258I, MET258J, MET318I, MET318J, MET327I, MET327J, PHE185I, PHE185J, PHE237I, PHE237J, PHE251I, PHE251J, PHE294I, PHE294J, PRO174I, PRO174J, PRO225I, PRO225J, SER108I, SER108J, SER242I, SER242J, SER300I, SER300J, SER305I, SER305J, SER313I, SER313J, THR107I, THR107J, THR151I, THR151J, THR154I, THR154J, THR163I, THR163J, THR184I, THR184J, THR200I, THR200J, THR245I, THR245J, THR247I, THR247J, THR290I, THR290J, TRP171I, TRP171J, TRP227I, TRP227J, TRP317I, TRP317J, TRP321I, TRP321J, TYR153I, TYR153J, VAL244I, VAL244J, VAL289I, VAL289J, VAL297I, VAL297J, VAL307I, VAL307J, VAL76I, VAL81I, VAL81J, VAL82I, VAL82J
• I-L: ALA256I, ALA256L, ALA26I, ALA26L, ALA285I, ALA285L, ALA28I, ALA28L, ALA292I, ALA292L, ALA296I, ALA296L, ALA301I, ALA301L, ALA315I, ALA315L, ALA330I, ALA330L, ALA67I, ALA67L, ALA71I, ALA71L, ALA77I, ALA77L, ARG119I, ARG119L, ARG293I, ARG293L, ARG312I, ARG312L, ARG340I, ARG340L, ARG73I, ARG73L, ASN281I, ASN281L, ASN284I, ASN284L, ASN295I, ASN295L, ASP17I, ASP17L, ASP29I, ASP29L, ASP31I, ASP31L, ASP68I, ASP68L, ASP79I, ASP79L, GLN253I, GLN253L, GLN298I, GLN298L, GLN304I, GLN304L, GLN310I, GLN310L, GLN326I, GLN326L, GLN344I, GLN344L, GLU22I, GLU22L, GLU260I, GLU260L, GLU286I, GLU286L, GLU309I, GLU309L, GLU320I, GLU320L, GLU7I, GLU7L, GLU85I, GLU85L, GLY13I, GLY13L, GLY16I, GLY16L, GLY252I, GLY269L, GLY314I, GLY314L, GLY316I, GLY316L, GLY75I, GLY75L, GLY80I, GLY80L, HIS303I, HIS303L, HIS74I, HIS74L, HIS8I, HIS8L, ILE112I, ILE112L, ILE20I, ILE20L, ILE21I, ILE21L, ILE299I, ILE299L, ILE30I, ILE30L, LEU11I, LEU11L, LEU14I, LEU14L, LEU23I, LEU23L, LEU257I, LEU257L, LEU288I, LEU288L, LEU291I, LEU291L, LEU302I, LEU302L, LEU319I, LEU319L, LEU322I, LEU322L, LEU324I, LEU324L, LEU336I, LEU3I, LEU3L, LEU72I, LEU72L, LEU86I, LEU86L, LYS27I, LYS27L, LYS78I, LYS78L, MET156I, MET156L, MET318I, MET318L, MET327I, MET327L, MET33I, MET33L, MET69I, MET69L, PHE10I, PHE10L, PHE15I, PHE15L, PHE24I, PHE24L, PHE294I, PHE294L, PHE6I, PHE6L, PRO282I, PRO282L, PRO325I, PRO325L, PRO5I, PRO5L, PRO9I, PRO9L, SER115I, SER115L, SER12I, SER12L, SER18I, SER18L, SER25I, SER25L, SER2I, SER2L, SER300I, SER300L, SER305I, SER305L, SER313I, SER313L, SER4I, SER4L, SER70I, SER70L, THR287I, THR287L, THR290I, THR290L, THR323I, THR323L, THR329I, THR329L, THR333I, THR333L, TRP317I, TRP317L, TRP321I, TRP321L, VAL283I, VAL283L, VAL289I, VAL289L, VAL297I, VAL297L, VAL307I, VAL307L, VAL328I, VAL328L, VAL337I, VAL337L, VAL76I, VAL76L, VAL81I, VAL81L, VAL82I, VAL82L, VAL83I, VAL83L
• I-K: ALA158I, ALA158K, ALA256I, ALA256K, ALA259I, ALA259K, ALA285I, ALA285K, ALA296I, ALA296K, ALA301I, ALA301K, ALA315I, ALA315K, ARG155I, ARG155K, ARG167I, ARG167K, ARG293I, ARG293K, ASN281I, ASN281K, ASN284I, ASN284K, ASP254I, ASP254K, GLN157I, GLN157K, GLN253I, GLN253K, GLN304I, GLN304K, GLU260I, GLU260K, GLU286I, GLU286K, GLY152I, GLY152K, GLY252I, GLY252K, GLY262I, GLY262K, ILE255I, ILE255K, ILE261I, ILE261K, ILE265I, ILE265K, LEU14I, LEU14K, LEU257I, LEU257K, LEU267I, LEU267K, LEU319I, LEU319K, MET156I, MET156K, MET258I, MET258K, PHE15I, PHE15K, PRO282I, PRO282K, SER300I, SER300K, SER305I, SER305K, THR151I, THR151K, THR154I, THR154K, THR287I, THR287K, THR290I, THR290K, TYR153I, TYR153K, VAL283I, VAL283K, VAL289I, VAL289K, VAL297I, VAL297K, VAL307I, VAL307K
• J-L: ALA158J, ALA158L, ALA256J, ALA256L, ALA259J, ALA259L, ALA285J, ALA285L, ALA296J, ALA296L, ALA301J, ALA301L, ALA315J, ALA315L, ARG155J, ARG155L, ARG167J, ARG167L, ARG293J, ARG293L, ASN281J, ASN281L, ASN284J, ASN284L, ASP254J, ASP254L, GLN157J, GLN157L, GLN253J, GLN253L, GLN304J, GLN304L, GLU260J, GLU260L, GLU286J, GLU286L, GLY252J, GLY252L, GLY262J, GLY262L, HIS303J, ILE255J, ILE255L, ILE261J, ILE261L, ILE265J, ILE265L, LEU14J, LEU14L, LEU257J, LEU257L, LEU267J, LEU267L, LEU319J, LEU319L, MET156J, MET156L, MET258J, MET258L, PHE15J, PHE15L, PRO282J, PRO282L, SER300J, SER300L, SER305J, SER305L, THR151J, THR151L, THR154J, THR154L, THR287J, THR287L, THR290J, THR290L, TYR153J, TYR153L, VAL283J, VAL283L, VAL289J, VAL289L, VAL297J, VAL297L, VAL307J, VAL307L
• J-K: ALA256J, ALA256K, ALA26J, ALA26K, ALA285J, ALA285K, ALA28J, ALA28K, ALA292J, ALA292K, ALA296J, ALA296K, ALA301J, ALA301K, ALA315J, ALA315K, ALA330J, ALA330K, ALA67J, ALA67K, ALA71J, ALA71K, ALA77J, ALA77K, ARG119J, ARG119K, ARG293J, ARG293K, ARG312J, ARG312K, ARG340J, ARG340K, ARG73J, ARG73K, ASN281J, ASN281K, ASN284J, ASN284K, ASN295J, ASN295K, ASP17J, ASP17K, ASP29J, ASP29K, ASP31J, ASP31K, ASP68J, ASP68K, ASP79J, ASP79K, GLN253J, GLN253K, GLN298J, GLN298K, GLN304J, GLN304K, GLN310J, GLN310K, GLN326J, GLN326K, GLN344J, GLN344K, GLN89J, GLN89K, GLU22J, GLU22K, GLU260J, GLU260K, GLU286J, GLU286K, GLU309J, GLU309K, GLU311J, GLU320J, GLU320K, GLU7J, GLU7K, GLU85J, GLU85K, GLY13J, GLY13K, GLY16J, GLY16K, GLY269J, GLY314J, GLY314K, GLY316J, GLY316K, GLY75J, GLY75K, GLY80J, GLY80K, HIS303J, HIS303K, HIS74J, HIS74K, HIS8J, HIS8K, ILE112J, ILE112K, ILE20J, ILE20K, ILE21J, ILE21K, ILE299J, ILE299K, ILE30J, ILE30K, LEU11J, LEU11K, LEU14J, LEU14K, LEU23J, LEU23K, LEU257J, LEU257K, LEU288J, LEU288K, LEU291J, LEU291K, LEU302J, LEU302K, LEU319J, LEU319K, LEU322J, LEU322K, LEU324J, LEU324K, LEU3J, LEU3K, LEU72J, LEU72K, LEU86J, LEU86K, LYS27J, LYS27K, LYS78J, LYS78K, MET156K, MET318J, MET318K, MET327J, MET327K, MET33J, MET33K, MET69J, MET69K, PHE10J, PHE10K, PHE15J, PHE15K, PHE24J, PHE24K, PHE294J, PHE294K, PHE6J, PHE6K, PRO282J, PRO282K, PRO325J, PRO325K, PRO5J, PRO5K, PRO9J, PRO9K, SER115J, SER115K, SER12J, SER12K, SER18J, SER18K, SER25J, SER25K, SER2J, SER2K, SER300J, SER300K, SER305J, SER305K, SER313J, SER313K, SER4J, SER4K, SER70J, SER70K, THR287J, THR287K, THR290J, THR290K, THR323J, THR323K, THR329J, THR329K, THR333J, THR333K, TRP317J, TRP317K, TRP321J, TRP321K, VAL283J, VAL283K, VAL289J, VAL289K, VAL297J, VAL297K, VAL307J, VAL307K, VAL328J, VAL328K, VAL337J, VAL337K, VAL76J, VAL76K, VAL81J, VAL81K, VAL82J, VAL82K, VAL83J, VAL83K
• L-K: ALA158K, ALA158L, ALA159K, ALA159L, ALA165K, ALA165L, ALA168K, ALA168L, ALA169K, ALA169L, ALA173K, ALA173L, ALA197K, ALA197L, ALA198K, ALA198L, ALA235K, ALA235L, ALA238K, ALA238L, ALA256K, ALA256L, ALA259L, ALA292K, ALA292L, ALA296K, ALA296L, ALA301K, ALA301L, ALA315K, ALA315L, ARG155K, ARG155L, ARG167K, ARG167L, ARG177K, ARG177L, ARG181K, ARG181L, ARG224K, ARG224L, ARG231K, ARG231L, ARG293K, ARG293L, ARG312K, ARG312L, ASN188L, ASN229K, ASN229L, ASN239K, ASN239L, ASN295K, ASN295L, ASP166K, ASP166L, ASP232K, ASP232L, ASP254K, ASP254L, ASP79K, ASP79L, GLN109K, GLN109L, GLN157K, GLN157L, GLN226K, GLN226L, GLN230K, GLN230L, GLN253K, GLN253L, GLN298K, GLN298L, GLN304K, GLN304L, GLN308K, GLN308L, GLN310K, GLN310L, GLU202K, GLU202L, GLU236K, GLU236L, GLU260K, GLU260L, GLU264L, GLU309K, GLU309L, GLU311K, GLU311L, GLY152K, GLY152L, GLY161K, GLY161L, GLY170K, GLY170L, GLY189K, GLY189L, GLY195K, GLY195L, GLY196K, GLY196L, GLY199K, GLY199L, GLY233K, GLY233L, GLY246K, GLY246L, GLY249K, GLY249L, GLY252K, GLY252L, GLY314K, GLY314L, GLY316K, GLY316L, GLY80K, GLY80L, HIS178K, HIS178L, HIS228K, HIS228L, HIS303K, HIS303L, ILE112K, ILE112L, ILE160K, ILE160L, ILE162K, ILE162L, ILE172K, ILE172L, ILE234K, ILE234L, ILE255K, ILE255L, ILE261K, ILE261L, ILE299K, ILE299L, LEU150K, LEU150L, LEU175K, LEU175L, LEU201K, LEU201L, LEU240K, LEU240L, LEU241K, LEU241L, LEU243K, LEU243L, LEU248K, LEU248L, LEU257K, LEU257L, LEU288K, LEU288L, LEU291K, LEU291L, LEU302K, LEU302L, LEU306K, LEU306L, LEU319K, LEU319L, LYS203K, LYS203L, LYS250K, LYS250L, MET156K, MET156L, MET258K, MET258L, MET318K, MET318L, MET327L, PHE185K, PHE185L, PHE237K, PHE237L, PHE251K, PHE251L, PHE294K, PHE294L, PRO174K, PRO174L, PRO225K, PRO225L, SER108K, SER108L, SER242K, SER242L, SER300K, SER300L, SER305K, SER305L, SER313K, SER313L, THR107K, THR107L, THR151K, THR151L, THR154K, THR154L, THR163K, THR163L, THR184K, THR184L, THR200K, THR200L, THR245K, THR245L, THR247K, THR247L, THR290K, THR290L, TRP171K, TRP171L, TRP227K, TRP227L, TRP317K, TRP317L, TRP321K, TRP321L, TYR153K, TYR153L, VAL244K, VAL244L, VAL289K, VAL289L, VAL297K, VAL297L, VAL307K, VAL307L, VAL81K, VAL81L, VAL82K